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Food Allergies

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https://www.readbyqxmd.com/read/28213955/the-skin-barrier-function-gene-spink5-is-associated-with-challenge-proven-ige-mediated-food-allergy-in-infants
#1
Sarah E Ashley, Hern-Tze Tina Tan, Peter Vuillermin, Shyamali C Dharmage, Mimi L K Tang, Jennifer Koplin, Lyle C Gurrin, Adrian Lowe, Caroline Lodge, Anne-Louise Ponsonby, John Molloy, Pamela Martin, Melanie C Matheson, Richard Saffery, Katrina J Allen, Justine A Ellis, David Martino
BACKGROUND: A defective skin barrier is hypothesised to be an important route of sensitisation to dietary antigens, and may lead to food allergy in some children. Missense mutations in the Serine peptidase inhibitor kazal type 5 (SPINK5) skin barrier gene have previously been associated with allergic conditions. OBJECTIVE: To determine whether genetic variants in and around SPINK5 are associated with IgE mediated food allergy. METHOD: We genotyped 71 'tag' single nucleotide polymorphisms (tag-SNPs) within a region spanning ~263 kilobases (kb) including SPINK5 (~61kb) in n=722 (n=367 food allergic, n=199 food sensitised, tolerant and n=156 non-food allergic controls) 12-month infants (discovery sample) phenotyped for food allergy with the gold standard oral food challenge (OFC)...
February 18, 2017: Allergy
https://www.readbyqxmd.com/read/28211346/need-for-emergency-epinephrine-to-treat-food-allergy-reactions-in-schools-in-the-hortaleza-district-in-madrid
#2
M Cabrera, J C Ortiz-Menéndez, B Garzón, L Barrios
No abstract text is available yet for this article.
2017: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/28211344/validation-of-recipes-for-double-blind-placebo-controlled-challenges-with-milk-egg-white-and-hazelnut
#3
E González-Mancebo, M D Alonso Díaz de Durana, Y García Estringana, A Meléndez Baltanás, M Rodriguez-Alvarez, B de la Hoz Caballer, N Del Prado, M Fernández-Rivas
BACKGROUND: The double-blind, placebo-controlled food challenge (DBPCFC) is considered the definitive diagnostic test for food allergy. Nevertheless, validated recipes for masking the foods are scarce, have not been standardized, and differ between centers. Sensory evaluation techniques such as the triangle test are necessary to validate the recipes used for DBPCFC. METHODS: We developed 3 recipes for use in DBPCFC with milk, egg white, and hazelnut and used the triangle test to validate them in a 2-phase study in which 197 volunteers participated...
2017: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/28211341/food-protein-induced-enterocolitis-syndrome
#4
REVIEW
A Nowak-Węgrzyn, E Jarocka-Cyrta, Apb Moschione Castro
Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-, cell-mediated food allergy of unknown prevalence and pathophysiology. Onset is typically during the first year of life; seafood-induced FPIES may start in adulthood. Acute FPIES manifests within 1-4 hours after ingestion with repetitive emesis, pallor, and lethargy progressing to dehydration and hypovolemic shock in 15% of cases. Chronic FPIES manifests with intermittent emesis, watery diarrhea, and poor growth progressing to dehydration and hypovolemic shock over a period of days to weeks...
2017: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/28211100/safety-and-feasibility-of-heated-egg-yolk-challenge-for-children-with-egg-allergies
#5
Noriyuki Yanagida, Sakura Sato, Tomoyuki Asaumi, Kiyotake Ogura, Magnus P Borres, Motohiro Ebisawa
BACKGROUND: Hen's egg allergy is a frequent cause of childhood food allergy. Egg yolk is used in various commonly consumed foods; if children with allergy to hen's egg could eat heated egg yolk, their quality of life (QOL) would improve. No reports exist regarding oral food challenges (OFCs) for heated egg yolk. We aimed to clarify whether pediatric patients allergic to hen's egg could consume heated egg yolk. METHODS: Data from pediatric patients who had undergone OFCs for heated egg yolk were evaluated retrospectively...
February 16, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28208101/berberine-as-a-chemical-and-pharmacokinetic-marker-of-the-butanol-extracted-food-allergy-herbal-formula-2
#6
Nan Yang, Kamal Srivastava, Ying Song, Changda Liu, Sool Cho, Yujuan Chen, Xiu-Min Li
RATIONALE: Food Allergy Herbal Formula 2 (FAHF-2) provided protection against peanut anaphylaxis in a murine model and induced beneficial immune-modulation in humans. Butanol-refined FAHF-2, B-FAHF-2, retained safety and efficacy in the peanut allergic murine model at only 1/5 of FAHF-2 dosage. One compound, berberine, was isolated and identified in vitro as a bioactive component present in FAHF-2 and B-FAHF-2. The aim of this study was to investigate berberine as a chemical and pharmacokinetic marker of B-FAHF-2...
February 13, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28208072/identification-of-triosephosphate-isomerase-as-a-novel-allergen-in-octopus-fangsiao
#7
Yang Yang, Zhong-Wei Chen, Barry K Hurlburt, Gui-Ling Li, Yong-Xia Zhang, Dan-Xia Fei, Hai-Wang Shen, Min-Jie Cao, Guang-Ming Liu
Octopus is an important mollusk in human dietary for its nutritional value, however it also causes allergic reactions in humans. Major allergens from octopus have been identified, while the knowledge of novel allergens remains poor. In the present study, a novel allergen with molecular weight of 28kDa protein was purified from octopus (Octopus fangsiao) and identified as triosephosphate isomerase (TIM) by mass spectrometry. TIM aggregated beyond 45°C, and its IgE-binding activity was affected under extreme pH conditions due to the altered secondary structure...
February 13, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28194191/prediction-of-clinical-peanut-allergy-status-among-children-in-hamilton-ontario-using-chart-review-data-collected-during-2012-2015
#8
Elizabeth Simms, Gary Foster, Katherine Arias, Mark Larché, Tosha Freitag, Tina Walker, Susanna Goncharova, Andrea Marrin, Andreas Freitag, Manel Jordana, Susan Waserman
BACKGROUND: Peanut sensitization does not necessarily indicate clinical peanut allergy, and uncertainty as to whether or not there is true peanut allergy can lead to increased anxiety and decreased quality of life for patients and their families. The gold standard for diagnosing clinical peanut allergy is the oral food challenge, but this method is time-consuming and can cause severe allergic reactions. It would therefore be beneficial to develop a tool for predicting clinical peanut allergy in peanut-sensitized individuals whose peanut allergy status is unknown so as to better determine who requires an oral food challenge for diagnosis...
2017: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/28194188/primum-non-nocere-first-do-no-harm-and-then-feed-peanut
#9
Kyla Jade Hildebrand, Elissa Michele Abrams, Timothy K Vander Leek, Julia Elizabeth Mainwaring Upton, Douglas P Mack, Linda Kirste, Christine McCusker, Sandeep Kapur
The Addendum Guidelines for the Prevention of Peanut Allergy in the United States-Report of the NIAID-Sponsored Expert Panel were developed to build on previous food allergy guidelines after several key studies demonstrated the benefit of early introduction of allergenic foods. These landmark studies including the Learning Early about Peanut (LEAP), LEAP-On and Enquiring about Tolerance trials created a paradigm shift in food allergy prevention. The "take home" messages of this guideline include that peanut should be introduced early in the first year of life, and for the majority of infants, peanut can be introduced at home...
2017: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/28192147/systemic-innate-immune-activation-in-food-protein-induced-enterocolitis-syndrome-fpies
#10
Ritobrata Goswami, Ana Belen Blazquez, Roman Kosoy, Adeeb Rahman, Anna Nowak-Wegrzyn, M Cecilia Berin
BACKGROUND: Food protein induced enterocolitis syndrome (FPIES) is a non-IgE-mediated food allergy of infancy whose pathophysiology is poorly understood. OBJECTIVES: We set out to identify and phenotype allergen-responsive cells in peripheral blood of a cohort of subjects undergoing supervised food challenge for FPIES. METHODS: We profiled antigen-responsive cells in peripheral blood mononuclear cells by flow cytometry, and examined cells in whole blood obtained before and after challenge by CyTOF mass cytometry and RNAseq...
February 9, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28185350/development-of-a-strategy-for-the-total-chemical-synthesis-of-an-allergenic-protein-the-peach-ltp-pru-p-3
#11
Sofie Buhler, Jaap H Akkerdaas, Thelma A Pertinhez, Ronald Van Ree, Arnaldo Dossena, Stefano Sforza, Tullia Tedeschi
The possibility to obtain allergenic proteins by means of total chemical synthesis would be a big step forward in the development of cures to food allergy and in the study of the mechanism of allergic reactions, because this would allow to achieve control at the molecular level over the structure of the product and to study its relationship with the allergenic activity in fine details. This is instead not possible by using allergens produced by extraction from natural sources or by recombinant DNA techniques...
February 10, 2017: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/28184046/investigating-the-accuracy-risk-impact-and-cost-effectiveness-of-component-resolved-diagnostic-test-for-food-allergy-a-systematic-review-protocol
#12
Javier Flores Kim, Bright I Nwaru, Nicola McCleary, Andrew Stoddart, Aziz Sheikh
No abstract text is available yet for this article.
December 2017: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/28181151/update-on-potential-therapies-for-ige-mediated-food-allergy
#13
REVIEW
Andrew MacGinnite
PURPOSE OF REVIEW: Food allergy is common, affecting up to 8% of children in the USA. Currently, therapy is limited to avoidance of the implicated allergen and availability of self-injectable epinephrine. However, several new approaches to food allergy are under investigation. This article reviews the published data on these new approaches. RECENT FINDINGS: Oral immunotherapy, in which allergic subjects are exposed to increasing amounts of antigen, can be accomplished in the majority of allergic individuals...
January 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28177443/the-spleen-is-the-site-where-mast-cells-are-induced-in-the-development-of-food-allergy
#14
Shota Toyoshima, Ei Wakamatsu, Yasuo Ishida, Yuuki Obata, Yosuke Kurashima, Hiroshi Kiyono, Ryo Abe
No abstract text is available yet for this article.
February 8, 2017: International Immunology
https://www.readbyqxmd.com/read/28174512/allergic-diseases-in-the-elderly-biological-characteristics-and-main-immunological-and-non-immunological-mechanisms
#15
REVIEW
Maria Teresa Ventura, Nicola Scichilone, Roberto Paganelli, Paola Lucia Minciullo, Vincenzo Patella, Matteo Bonini, Giovanni Passalacqua, Carlo Lombardi, Livio Simioni, Erminia Ridolo, Stefano R Del Giacco, Sebastiano Gangemi, Giorgio Walter Canonica
Life expectancy and the number of elderly people are progressively increasing around the world. Together with other pathologies, allergic diseases also show an increasing incidence in geriatric age. This is partly due to the growing emphasis on a more accurate and careful diagnosis of the molecular mechanisms that do not allow to ignore the real pathogenesis of many symptoms until now unknown, and partly to the fact that the allergic people from 20 years ago represent the elderly population now. Moreover, environmental pollution predisposes to the onset of allergic asthma and dermatitis which are the result of internal pathologies more than the expression of allergic manifestations...
2017: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/28173607/review-suggests-that-the-immunoregulatory-and-anti-inflammatory-properties-of-allergenic-foods-can-provoke-oral-tolerance-if-introduced-early-to-infants-diets
#16
REVIEW
Despina-Zoe T Mermiri, Theodora Lappa, Athina L Papadopoulou
: For years, the advice was to postpone introducing allergenic foods, in order to prevent food allergies. However, food allergies have escalated rather than declined and our review of the latest epidemiological, immunological and nutritional research suggests that early weaning practices may be beneficial. The most allergenic foods, such as fish, eggs and peanuts, have proved to be inherently rich in tolerogenic substances that can play a significant role in preventing allergies. CONCLUSION: We found evidence that the immunoregulatory and anti-inflammatory properties of allergenic foods can provoke oral tolerance if introduced early to both low-risk and high-risk infants...
February 7, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28171712/sensitization-to-common-allergens-among-patients-with-allergy-in-major-iranian-cities-a-systemic-review-and-meta-analysis
#17
Mozhgan Moghtaderi, Saeed Hosseini Teshnizi, Shirin Farjadsh
Purpose: Various allergens are implicated in the pathogenesis of allergic diseases in different regions. This study attempted to identify the most common allergens among patients with allergy based on results of skin prick tests in different parts of Iran. Methods: Relevant studies were identified from the Medline database from 2000 to 2016. Six common groups of allergens including animals, cockroaches, foods, fungi, house dust mites and pollen were considered. Subgroup analysis was performed to determine prevalence of each type of allergens...
February 5, 2017: Epidemiology and Health
https://www.readbyqxmd.com/read/28169852/gallate-contact-dermatitis-systematic-review-and-product-update
#18
Zachary E Holcomb, Megan G Van Noord, Amber Reck Atwater
Allergic contact dermatitis related to cosmetic use can result from allergens not routinely evaluated by standard patch test protocols. Propyl, octyl, and dodecyl gallates are commonly used as antioxidant preservatives with reports of associated allergic contact dermatitis in the literature. The objectives of this review were to investigate the role of gallates in allergic contact dermatitis and to explore products containing these preservatives. A systematic review of the literature through April 2016 was performed to explore cases of reported gallate allergy...
February 6, 2017: Dermatitis
https://www.readbyqxmd.com/read/28167094/international-consensus-guidelines-for-the-diagnosis-and-management-of-food-protein-induced-enterocolitis-syndrome-workgroup-report-of-the-adverse-reactions-to-foods-committee-american-academy-of-allergy-asthma-and-immunology
#19
A Nowak-Węgrzyn, M Chehade, M Groetch, J M Spergel, R A Wood, K Allen, D Atkins, S Bahna, A Barad, C Berin, T Brown Whitehorn, A W Burks, J C Caubet, A Cianferoni, M Conte, C Davis, A Fiocchi, K Grimshaw, R Gupta, B Hofmeister, J B Hwang, Y Katz, G N Konstantinou, S A Leonard, J Lightdale, S McGhee, S Mehr, S Miceli Sopo, G Monti, A Muraro, S Noel, I Nomura, S Noone, H A Sampson, F Schultz, S H Sicherer, C Thompson, P Turner, C Venter, A Westcott-Chavez, M Greenhawt
No abstract text is available yet for this article.
February 3, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28163999/food-allergy-a-rare-cause-of-recurrent-intussusception
#20
Emrah Aydın, Ömer Faruk Beşer
Recurrent intussusception is a management dilemma and have many causes. We report a 22-month old boy who presented multiple times for recurrent intussusception. At diagnostic work-up he was found to be suffering from non-IgE food allergy. The child did not develop further episodes of intussusception after removal of allergenic diet.
January 2017: APSP Journal of Case Reports
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