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https://www.readbyqxmd.com/read/28719547/growth-modulation-in-achondroplasia
#1
Philip K McClure, Eray Kilinc, John G Birch
INTRODUCTION: Achondroplasia is the most common skeletal dysplasia with a rate of nearly 1/10,000. The development of lower extremity deformity is well documented, and various modes of correction have been reported. There are no reports on the use of growth modulation to correct angular deformity in achondroplasia. METHODS: Medical Records from 1985 to 2015 were reviewed for the diagnosis of achondroplasia and growth modulation procedures. Patients who had been treated for angular deformity of the legs by growth modulation were identified...
July 17, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28718307/late-post-treatment-radiographic-changes-3-years-following-chemoradiation-for-glioma-the-importance-of-histopathology
#2
Joao R Galante, Fausto Rodriguez, Stuart A Grossman, Roy E Strowd
Treatment-related changes can mimic brain tumor progression both clinically and radiographically. Distinguishing these two entities represents a major challenge in neuro-oncology. No single imaging modality is capable of reliably achieving such distinction. While histopathology remains the gold standard, definitive pathological criteria are also lacking which can further complicate such cases. We report a patient with high-grade glioma who, after initially presenting with histopathologically confirmed pseudoprogression 10 months following treatment, re-presented 3 years following concurrent chemoradiation with clinical and radiographic changes that were most consistent with progressive disease but for which histopathology revealed treatment effects without active glioma...
July 18, 2017: CNS Oncology
https://www.readbyqxmd.com/read/28717790/soft-and-hard-tissue-response-%C3%A2-to-an-implant-with-a-convergent-%C3%A2-collar-in-the-esthetic-area-%C3%A2-preliminary-report-at-18-months
#3
Luigi Canullo, Marco Tallarico, Guillermo Pradies, Fabio Marinotti, Ignazio Loi, Roberto Cocchetto
AIM: The purpose of this prospective cohort study was to investigate, over an 18-month period, soft and hard tissue response to a transmucosal implant with a convergent collar inserted in the anterior maxillary esthetic area. MATERIALS AND METHODS: From June 2013 to January 2014, 14 consecutive patients were enrolled (7 men and 7 women; mean age 63.7 ± 14 years) with 20 implants, needing at least one implant-supported restoration between the canines in the maxillary anterior esthetic area...
2017: International Journal of Esthetic Dentistry
https://www.readbyqxmd.com/read/28716296/clinical-and-radiologic-predictive-factors-of-rib-fractures-in-outpatients-with-chest-pain
#4
REVIEW
Liang Zhang, Colm J McMahon, Samir Shah, Jim S Wu, Ronald L Eisenberg, Justin W Kung
PURPOSE: To identify the clinical and radiologic predictive factors of rib fractures in stable adult outpatients presenting with chest pain and to determine the utility of dedicated rib radiographs in this population of patients. METHOD AND MATERIALS: Following Institutional Review Board approval, we performed a retrospective review of 339 consecutive cases in which a frontal chest radiograph and dedicated rib series had been obtained for chest pain in the outpatient setting...
May 30, 2017: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/28714498/chondrodysplasia-punctata-a-case-report-of-fetal-warfarin-syndrome
#5
S Songmen, O B Panta, S S Paudel, R K Ghimire
Chondrodysplasia punctata is abnormal calcification in the cartilage of developing bones and has been seen in association with deranged vitamin K metabolism. Warfarin, an oral anticoagulant acting on vitamin K dependent clotting factors is known to cause chondrodysplasia punctata. Despite the knowledge of the condition the management of patients with prosthetic heart valves might require use of the drug for anticoagulation. Here, we present a case of a fetal warfarin syndrome in a second born child of a 27 year lady under warfarin for prosthetic heart valve...
January 2017: Journal of Nepal Health Research Council
https://www.readbyqxmd.com/read/28712898/iatrogenic-vertebral-artery-injury-during-anterior-cervical-spine-surgery-a-systematic-review
#6
REVIEW
Qing Guan, Long Chen, Ye Long, Zhou Xiang
BACKGROUND: Iatrogenic vertebral artery injury (VAI) during anterior cervical surgery is rare but potentially catastrophic. METHOD: The causes, presentation, diagnosis, management, prognosis, and prevention of VAI were reviewed following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. English-language studies and case reports published from 1980 to 2017 were retrieved. Data on diagnosis, surgical procedures and approach, site and cause of VAI, management, outcomes, and VA status were extracted...
July 13, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28712789/the-role-of-lymph-node-dissection-in-the-contemporary-management-of-renal-cell-carcinoma-a-critical-appraisal-of-the-evidence
#7
EDITORIAL
Joseph Brito, Boris Gershman
The role of lymph node dissection (LND) in the management of renal cell carcinoma has been controversial. Older studies provided initial support to a potential survival benefit in resection of lymph node metastases, and several predictive models were developed to identify patients with lymph node involvement. However, the only randomized trial on the subject did not report a survival benefit to LND in the nonmetastatic setting. Several studies have recently reexplored the therapeutic benefit of LND. In both nonmetastatic and metastatic settings, LND does not appear to be associated with a survival benefit...
July 13, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28712787/untethering-physiolysis-for-delta-phalanx-longitudinally-bracketed-diaphysis-combined-with-free-fat-interposition-graft
#8
H-J Lee, P-T Kim, I-H Jeon, M F Deslivia, S-J Lee, H-J Kim, J-P Yoon
We report the results of physiolysis of the epiphyseal bracket combined with free fat grafting for the treatment of delta phalanx. Thirteen cases (five patients) were included. Mean patient age was 6.6years (range, 4-9). The patients underwent physiolysis in which the epiphyseal bracket was cut and replaced with a free fat graft. The angle between the long axis of the proximal and distal phalanges and the ratio between the width and length of the affected middle phalanx were evaluated on plain radiographs. The range of motion in the fingers was also evaluated...
July 13, 2017: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/28712634/management-of-dens-invaginatus-type-ii-associated-with-immature-apex-and-large-periradicular-lesion-using-platelet-rich-fibrin-and-biodentine
#9
Shruti Goel, Ruchika Roongta Nawal, Sangeeta Talwar
Dens invaginatus (DI) poses peculiar challenges in endodontic treatment of teeth because of distortion of pulpal space. A case of Oehlers type II DI with open apex and large periapical lesion is reported. The case was managed using cone-beam computed tomography (CBCT), operating microscope, platelet-rich fibrin (PRF), and Biodentine. A 15-year-old male patient presented with palatal swelling. Pulp sensibility testing of right maxillary lateral incisor was negative. Intraoral periapical digital radiograph revealed an Oehlers type II DI with open apex and periapical radiolucency...
July 13, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28712488/staged-reconstruction-of-diaphyseal-fractures-with-segmental-defects-surgical-and-patient-reported-outcomes
#10
S D Zoller, L A Cao, R A Smith, W Sheppard, E L Lord, C D Hamad, J H Ghodasra, C Lee, D Jeffcoat
INTRODUCTION: Two-stage limb reconstruction is an option for patients with critical size segmental bone defects following acute trauma or non-union. Reconstruction is technically demanding and associated with a high complication rate. Current protocols for limb reconstruction have well-documented challenges, and no study has reported on patient outcomes using a validated questionnaire. In this study, we aimed to examine the clinical and patient-centered outcomes following our surgical protocol for two-stage limb reconstruction following critical size segmental defects...
June 23, 2017: Injury
https://www.readbyqxmd.com/read/28712145/resolution-rate-of-pulmonary-sarcoidosis-and-its-related-factors-in-a-japanese-population
#11
Takeshi Hattori, Satoshi Konno, Noriharu Shijubo, Mitsuhide Ohmichi, Tetsuo Yamaguchi, Masaharu Nishimura
BACKGROUND AND OBJECTIVE: A number of previous studies have reported on the rate of resolution of pulmonary sarcoidosis and its associated factors. However, most of the studies were conducted several decades ago and no similar surveys have been conducted in recent years. The aim of this study was to evaluate the rate of resolution of pulmonary sarcoidosis and its related factors in recently diagnosed patients, and to compare the results with those from previous studies. METHODS: This study included 306 patients who had been newly diagnosed with pulmonary sarcoidosis between 2000 and 2009 in Sapporo, Japan...
July 16, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28711604/an-animal-model-of-co-existing-sarcopenia-and-osteoporotic-fracture-in-senescence-accelerated-mouse-prone-8-samp8
#12
Ning Zhang, Simon Kwoon Ho Chow, Kwok Sui Leung, Ho Hin Lee, Wing Hoi Cheung
Sarcopenia and osteoporotic fracture are common aging-related musculoskeletal problems. Recent evidences report that osteoporotic fracture patients showed high prevalence of sarcopenia; however, current clinical practice basically does not consider sarcopenia in the treatment or rehabilitation of osteoporotic fracture. There is almost no report studying the relationship of the co-existing of sarcopenia and osteoporotic fracture healing. In this study, we validated aged senescence accelerated mouse prone 8 (SAMP8) and senescence accelerated mouse resistant 1 (SAMR1) as animal models of senile osteoporosis with/without sarcopenia...
July 12, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28711582/a-novel-wnt-pathway-inhibitor-sm04690-for-the-treatment-of-moderate-to-severe-osteoarthritis-of-the-knee-results-of-a-24-week-randomized-controlled-phase-1-study
#13
Yusuf Yazici, Timothy E McAlindon, Roy Fleischmann, Allan Gibofsky, Nancy E Lane, Alan J Kivitz, Nebojsa Skrepnik, Eddie Armas, Christopher J Swearingen, Anita DiFrancesco, Jeyanesh R S Tambiah, John Hood, Marc C Hochberg
OBJECTIVE: To assess the safety, pharmacokinetics, and exploratory efficacy of SM04690, a novel Wnt pathway inhibitor, as a potential disease modifying treatment for knee OA. DESIGN: Subjects with Kellgren-Lawrence grade 2-3 knee OA were randomized in successive dose-escalation cohorts to receive a knee intra-articular injection with 0.03, 0.07, or 0.23 mg SM04690, or placebo (PBO) (4:1 ratio). Safety, pharmacokinetics, efficacy (WOMAC Total/Function/Pain, Pain VAS, Physician Global Assessment [MDGA], and OMERACT-OARSI Response), OA-related biomarker (P1NP, ß-CTX, and COMP), and radiographic/imaging data were collected at baseline and during 24-week follow-up...
July 12, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28710894/short-frontal-plane-fractures-involving-the-dorsoproximal-articular-surface-of-the-proximal-phalanx-description-of-the-injury-and-a-technique-for-repair
#14
I M Wright, G Minshall
BACKGROUND: Chip fractures of the dorsoproximal articular margin of the proximal phalanx are common injuries in racehorses. Large fractures can extend distal to the joint capsule insertion and have been described as dorsal frontal fractures. OBJECTIVES: To report the location and morphology of short frontal plane fractures involving the dorsoproximal articular surface of the proximal phalanx and to describe a technique for repair under arthroscopic and radiographic guidance...
July 15, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/28710606/sbrt-for-hepatocellular-carcinoma-8-year-experience-from-a-regional-transplant-center
#15
Haoming Qiu, Michael J Moravan, Michael T Milano, Kenneth Y Usuki, Alan W Katz
PURPOSE: The study aimed to evaluate stereotactic body radiotherapy (SBRT) for hepatocellular carcinoma (HCC) in patients not eligible for liver transplant (LT). METHODS: We retrospectively identified transplant-ineligible HCC patients treated with SBRT to the liver between 2004 and 2013. Our primary endpoint was overall survival (OS). We also report treatment toxicities using CTCAE 3.0, radiographic response, and patterns of failure. RESULTS: We identified 93 patients with median age at SBRT of 65...
July 14, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/28710342/vincristine-ifosfamide-and-doxorubicin-for-initial-treatment-of-ewing-sarcoma-in-adults
#16
Michael J Wagner, Vancheswaran Gopalakrishnan, Vinod Ravi, J Andrew Livingston, Anthony P Conley, Dejka Araujo, Neeta Somaiah, Maria A Zarzour, Ravin Ratan, Wei-Lien Wang, Shreyaskumar R Patel, Alexander Lazar, Joseph A Ludwig, Robert S Benjamin
BACKGROUND: There are no clinical trials specifically addressing chemotherapy for adults with Ewing sarcoma (ES). Five-year event-free survival (EFS) of adults on pediatric studies of ES (44%-47%) is worse than that of children treated with the same therapy (69%). The object of this study was to review the results of therapy with vincristine, ifosfamide, and doxorubicin (VID) in the multidisciplinary treatment of adults with ES at our institution. MATERIALS AND METHODS: Charts for adults treated for ES from 1995 to 2011 were retrospectively reviewed...
July 14, 2017: Oncologist
https://www.readbyqxmd.com/read/28710242/pseudomonas-aeruginosa-as-an-unusual-cause-of-cavitating-lung-lesion
#17
Justin D Salciccioli, Hannah Woodcock, Mathina Darmalingam
A 31-year-old woman with systemic lupus erythematosus presented to the emergency department with cough for 1 week. Chest radiograph demonstrated cavitating lesion in the right upper zone with surrounding ground-glass change. Blood culture results from the day of hospital presentation grew Pseudomonas aeruginosa Sputum sample and pleural fluid grew P. aeruginosa and were negative for acid-fast bacilli. P. aeruginosa is a rare cause of cavitating lung lesion and has been associated with immunocompromised hosts...
July 14, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28709273/laser-driven-shock-waves-studied-by-x-ray-radiography
#18
L Antonelli, S Atzeni, A Schiavi, S D Baton, E Brambrink, M Koenig, C Rousseaux, M Richetta, D Batani, P Forestier-Colleoni, E Le Bel, Y Maheut, T Nguyen-Bui, X Ribeyre, J Trela
Multimegabar laser-driven shock waves are unique tools for studying matter under extreme conditions. Accurate characterization of shocked matter is for instance necessary for measurements of equation of state data or opacities. This paper reports experiments performed at the LULI facility on the diagnosis of shock waves, using x-ray-absorption radiography. Radiographs are analyzed using standard Abel inversion. In addition, synthetic radiographs, which also take into account the finite size of the x-ray source, are generated using density maps produced by hydrodynamic simulations...
June 2017: Physical Review. E
https://www.readbyqxmd.com/read/28708981/a-comparison-of-the-validity-of-the-demirjian-willems-nolla-and-h%C3%A3-%C3%A3-vikko-methods-in-determination-of-chronological-age-of-5-15-year-old-indian-children
#19
Sapna Hegde, Akash Patodia, Uma Dixit
BACKGROUND: Demirjian's method has been the most popular and extensively tested radiographic method of age estimation. More recently, Willems' method has been reported to be a better predictor of age. Nolla's and Häävikko's methods have been used to a lesser extent. Very few studies have compared all four methods in non-Indian and Indian populations. Most Indian research is limited by inadequate sample sizes, age structures and grouping and different approaches to statistical analysis...
July 5, 2017: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/28708924/bone-and-soft-tissue-response-in-bone-level-implants-restored-with-platform-switching-a-5-year-clinical-prospective-study
#20
Laura Lago, Luis da Silva, Francisco Gude, Benito Rilo
PURPOSE: The aim of this prospective study was to evaluate radiographic levels of peri-implant bone crest as well as soft tissue response, papilla height, and buccal mucosa recession, in bone-level implants restored with platform switching after 1-year and 5-year follow-ups. MATERIALS AND METHODS: This prospective study called for the placement of 59 implants to obtain a target of 90% power. To compensate for possible dropouts, the sample size was adjusted to 67 implants...
July 2017: International Journal of Oral & Maxillofacial Implants
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