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https://www.readbyqxmd.com/read/28549019/ocular-genetics-in-taiwan
#1
Yu-Hung Lai, Kwou-Yeung Wu
PURPOSE OF REVIEW: Ocular genetics is an emerging specialty which has accompanied the advancement of modern genetic technology. This review is to understand the current status of practice in ocular genetics in Taiwan. RECENT FINDINGS: There is only one ocular genetics clinic in Taiwan. Certified clinical laboratories provide few gene tests in ocular genetics. Most ocular genetic study is focused on myopia. Financial obstacles are a major problem for patients to seek gene tests...
April 25, 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28548893/dynamic-decision-making-learning-processes-and-new-research-directions
#2
Cleotilde Gonzalez, Pegah Fakhari, Jerome Busemeyer
OBJECTIVE: The aim of this manuscript is to provide a review of contemporary research and applications on dynamic decision making (DDM). BACKGROUND: Since early DDM studies, there has been little systematic progress in understanding decision making in complex, dynamic systems. Our review contributes to better understanding of decision making processes in dynamic tasks. METHOD: We discuss new research directions in DDM to highlight the value of simplification in the study of complex decision processes, divided into experimental and theoretical/computational approaches, and focus on problems involving control tasks and search-and-choice tasks...
May 1, 2017: Human Factors
https://www.readbyqxmd.com/read/28548291/practitioner-review-empirical-evolution-of-youth-psychotherapy-toward-transdiagnostic-approaches
#3
REVIEW
Lauren Krumholz Marchette, John R Weisz
BACKGROUND: Psychotherapy for children and adolescents (herein, 'youths') has grown more precise and focused over the decades, shifting toward empirically supported treatments standardized via therapist manuals. The manuals have increasingly emphasized precise targeting of single disorders or problems, or homogenous clusters. These focal treatments represent a valuable advance, with intervention benefit documented in hundreds of studies. However, relatively few of these treatments are widely used in everyday clinical practice, and their level of benefit may not be ideal, particularly in practice contexts and when compared to usual clinical care...
May 26, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28547911/from-light-capture-to-metabolic-needs-oxygenic-photosynthesis-is-an-ever-expanding-field-of-study-in-plants-algae-and-cyanobacteria
#4
EDITORIAL
Pierre Cardol, Anja Krieger-Liszkay
Understanding of the molecular mechanisms of photosynthetic electron and proton transports and their regulation in plants and algae in response to changes in environmental conditions is an important issue for fundamental research on photosynthesis, and may extend even to practical applications by identifying important sites for improvement of photosynthesis. The significance and often centrality of regulatory mechanisms of photosynthetic electron transport is well established for processes in plant acclimation...
May 26, 2017: Physiologia Plantarum
https://www.readbyqxmd.com/read/28546826/ipf-lasso-integrative-l1-penalized-regression-with-penalty-factors-for-prediction-based-on-multi-omics-data
#5
Anne-Laure Boulesteix, Riccardo De Bin, Xiaoyu Jiang, Mathias Fuchs
As modern biotechnologies advance, it has become increasingly frequent that different modalities of high-dimensional molecular data (termed "omics" data in this paper), such as gene expression, methylation, and copy number, are collected from the same patient cohort to predict the clinical outcome. While prediction based on omics data has been widely studied in the last fifteen years, little has been done in the statistical literature on the integration of multiple omics modalities to select a subset of variables for prediction, which is a critical task in personalized medicine...
2017: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/28546604/advanced-injectable-practice-training
#6
(no author information available yet)
No abstract text is available yet for this article.
May 26, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28546389/embracing-uncertainty-to-advance-diagnosis-in-general-practice
#7
EDITORIAL
Kirsti Malterud, Ann Dorrit Guassora, Susanne Reventlow, Annemarie Jutel
No abstract text is available yet for this article.
June 2017: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/28546055/the-long-way-of-implementing-patient-centered-care-and-shared-decision-making-in-germany
#8
Martin Härter, Jörg Dirmaier, Isabelle Scholl, Norbert Donner-Banzhoff, Marie-Luise Dierks, Wolfgang Eich, Hardy Müller, David Klemperer, Klaus Koch, Christiane Bieber
The main focus of the paper is on the description of the development and current state of research and implementation of patient-centered care (PCC) and shared decision-making (SDM) after fifteen years of substantial advances in health policy and health services research. What is the current state of SDM in health policy? The "Law on Patients' Rights" from 2013 standardizes all rights and responsibilities within the framework of medical treatment for German citizens and legal residents. This comprises the right to informed decisions, comprehensive and comprehensible information for patients, and decisions based on a clinician-patient-partnership...
May 22, 2017: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://www.readbyqxmd.com/read/28545931/validating-a-questionnaire-prehospital-preparedness-for-pediatric-trauma-patients
#9
Karin Bölenius, Christin Vestin, Britt-Inger Saveman, Lina Gyllencreutz
In recent decades, prehospital emergency care has undergone extensive development. Today, prehospital emergency nurses (PENs) are well trained and provide advanced care to patients of all ages. Caring for pediatric trauma patients is considered to be particularly demanding. However, in Sweden and internationally, there is a lack of research regarding PENs' preparedness for caring for pediatric trauma patients. OBJECTIVE: The development and testing of a questionnaire on self-reported preparedness among PENs caring for pediatric trauma patients in a prehospital emergency setting...
May 22, 2017: International Emergency Nursing
https://www.readbyqxmd.com/read/28545927/stem-cells-to-restore-insulin-production-and-cure-diabetes
#10
V Sordi, S Pellegrini, M Krampera, P Marchetti, A Pessina, G Ciardelli, G Fadini, C Pintus, G Pantè, L Piemonti
BACKGROUND: The advancement of knowledge in the field of regenerative medicine is increasing the therapeutic expectations of patients and clinicians on cell therapy approaches. Within these, stem cell therapies are often evoked as a possible therapeutic option for diabetes, already ongoing or possible in the near future. AIM: The purpose of this document is to make a point of the situation on existing knowledge and therapies with stem cells to treat patients with diabetes by focusing on some of the aspects that most frequently raise curiosity and discussion in clinical practice and in the interaction with the patient...
February 21, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28545579/evaluation-of-a-laboratory-quality-assurance-pilot-programme-for-malaria-diagnostics-in-low-transmission-areas-of-kenya-2013
#11
Elizabeth Wanja, Rachel Achilla, Peter Obare, Rose Adeny, Caroline Moseti, Victor Otieno, Collins Morang'a, Ephantus Murigi, John Nyamuni, Derek R Monthei, Bernhards Ogutu, Ann M Buff
BACKGROUND: One objective of the Kenya National Malaria Strategy 2009-2017 is scaling access to prompt diagnosis and effective treatment. In 2013, a quality assurance (QA) pilot was implemented to improve accuracy of malaria diagnostics at selected health facilities in low-transmission counties of Kenya. Trends in malaria diagnostic and QA indicator performance during the pilot are described. METHODS: From June to December 2013, 28 QA officers provided on-the-job training and mentoring for malaria microscopy, malaria rapid diagnostic tests and laboratory QA/quality control (QC) practices over four 1-day visits at 83 health facilities...
May 25, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28545194/knowledge-attitudes-and-preventive-practice-towards-breast-cancer-among-general-practitioner-health-professionals-in-morocco
#12
Naima Abda, Adil Najdi, Samira El Fakir, Nabil Tachfouti, Mohamed Berraho, Youssef Chami Khazraji, Loubna Abousselham, Latifa Belakhel, Rachid Bekkali, Chakib Nejjari
Background: Breast cancer is the most common cancer of women in Morocco and its diagnosis is usually made at advanced stages. The aim of this study was to describe the knowledge, practices and attitudes of general practitioners regarding early detection of breast cancer. Methods: A cross-sectional study was carried out during July 2011 on a sample of 140 general practitioners employed in basic health care facilities. Results: The majority (85.7%) of general practitioners were aware of the existence of a ministerial circular which aimed to generalize breast cancer screening...
April 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28544805/a-comparison-of-attitudes-to-laryngeal-cancer-treatment-outcomes-a-time-trade-off-study
#13
David W Hamilton, Ami Pedersen, Hannah Blanchford, Janneke E Bins, Peter McMeekin, Richard Thomson, Vinidh Paleri, Janet A Wilson
DESIGN: Time trade-off choice experiment. SETTING: Two large head and neck cancer centres. PARTICIPANTS: Patients who have received treatment for head and neck cancer and members of the head and neck cancer multidisciplinary team. MAIN OUTCOME MEASURES: Participants were asked to rank the outcome scenarios, assign utility values using time trade-off and rate the importance of survival on treatment choice. RESULTS: 49 head and neck cancer patients and 73 staff members were recruited...
May 19, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28544696/increased-incidence-of-liver-cancer-after-successful-daa-treatment-of-chronic-hepatitis-c-fact-or-fiction
#14
Alfredo Alberti, Sara Piovesan
Therapy of hepatitis C has been revolutionized by Direct Antiviral Agents. These drugs are safe and efficacious in all infected patients, including those with advanced, or decompensated cirrhosis, and are currently largely used in such cases in clinical practice worldwide. It was therefore cause of great concern the publication of two reports suggesting that treatment with DAAs could increase the risk of hepatocellular carcinoma in cirrhotic patients, particularly in those receiving antiviral therapy after having been cured for an HCC...
June 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28544366/enumeration-of-wt1-specific-cd8-t-cells-for-clinical-application-using-an-mhc-streptamer-based-no-wash-single-platform-flow-cytometric-assay
#15
Sarah Matko, Madeleine Teichert, Antje Tunger, Marc Schmitz, Martin Bornhauser, Torsten Tonn, Marcus Odendahl
The advent of novel strategies to generate leukemia-associated-antigen (LAA)-specific T cells for adoptive immunotherapies creates a demand for standardized good laboratory practice (GLP)-compliant enumeration assays to provide a secure clinical environment-whether it is to identify potential donors, define therapeutic doses for transplantation, or monitor clinical success. Here, we introduce a no-wash assay based on single-platform cell enumeration and Streptamer staining to determine the Wilms' tumor antigen 1 (WT1)-specific T cell immunity in clinical samples...
May 25, 2017: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
https://www.readbyqxmd.com/read/28544037/using-experience-based-co-design-for-the-development-of-physical-activity-provision-in-non-acute-rehabilitation-and-recovery-mental-health-care
#16
Evan Matthews, Mary Cowman, Suzanne Denieffe
Despite advances in recovery focused mental health care, people with severe mental illness (SMI) experience multiple physical comorbidity compounded by unhealthy lifestyle behaviours including low levels of physical activity (Vancampfort et al. 2017; Walker et al. 2015). Responding to this, international policy is moving to include physical activity as part of fundamental care for people with severe mental illness (Pratt et al. 2016; Richardson et al. 2005). Incorporation of physical activity into mental health service provision should adopt an approach that is in keeping with best practice, recovery orientated guidelines of mental health service provision, with particular consideration shown to incorporating service users as partners in care plan development and delivery (Department of Health, 2001; Department of Health and Children, 2006)...
May 19, 2017: Journal of Psychiatric and Mental Health Nursing
https://www.readbyqxmd.com/read/28543881/a-review-of-blood-sample-handling-and-pre-processing-for-metabolomics-studies
#17
REVIEW
Vinicius Veri Hernandes, Coral Barbas, Danuta Dudzik
Metabolomics has been found to be applicable to a wide range of clinical studies, bringing a new era for improving clinical diagnostics, early disease detection, therapy prediction and treatment efficiency monitoring. A major challenge in metabolomics, particularly untargeted studies, is the extremely diverse and complex nature of biological specimens. Despite great advances in the field there still exist fundamental needs for considering pre-analytical variability that can introduce bias to the subsequent analytical process and decrease the reliability of the results and moreover confound final research outcomes...
May 19, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28543705/empirical-and-pragmatic-adequacy-of-grounded-theory-advancing-nurse-empowerment-theory-for-nurses-practice
#18
Sonia A Udod, Louise Racine
AIMS AND OBJECTIVE: Drawing on the findings of a grounded theory study aimed at exploring how power is exercised in nurse-manager relationships in the hospital setting, this paper examines the empirical and pragmatic adequacy of grounded theory as a methodology to advance the concept of empowerment in the area of nursing leadership and management. BACKGROUND: The evidence on staff nurse empowerment has highlighted the magnitude of individual and organizational outcomes, but has not fully explicated the micro-level processes underlying how power is exercised, shared or created within the nurse-manager relationship...
May 25, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28543648/making-the-choices-necessary-to-make-a-difference-the-responsibility-of-national-bioethics-commissions
#19
Christine Grady
In this essay, I offer some reflections on how the topics were identified and approached by the Presidential Commission for the Study of Bioethical Issues, on which I had the honor to serve, in the hope that the reflections may be useful to future national bioethics commissions. In the executive order that established the bioethics commission, President Obama explicitly recognized the ethical imperative to responsibly pursue science, innovation, and advances in biomedical research and health care, and the importance of national attention to these issues...
May 2017: Hastings Center Report
https://www.readbyqxmd.com/read/28543640/electric-properties-tomography-biochemical-physical-and-technical-background-evaluation-and-clinical-applications
#20
REVIEW
Ulrich Katscher, Cornelius A T van den Berg
Electric properties tomography (EPT) derives the patient's electric properties, i.e. conductivity and permittivity, using standard magnetic resonance (MR) systems and standard MR sequences. Thus, EPT does not apply externally mounted electrodes, currents or radiofrequency (RF) probes, as is the case in competing techniques. EPT is quantitative MR, i.e. it yields absolute values of conductivity and permittivity. This review summarizes the physical equations underlying EPT, the corresponding basic and advanced reconstruction techniques and practical numerical aspects to realize these reconstruction techniques...
May 24, 2017: NMR in Biomedicine
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