Roy Pétronille, Do Bernard, Le Guyader Guillaume, Viellard Victoire, Fleury Thomas, Conq Jérôme, Da Costa Eloïse, Pierron Gérard, Souquere Sylvie, Solgadi Audrey, Lemare François, Delaloge Suzette, Paul Muriel, Annereau Maxime
Several cases of fatal enterocolitis have been described in association with the use of docetaxel (DTX), and this increase in adverse events has been concomitant with a change in formulation. Indeed in 2010, a new DTX-based presentation has been introduced in the form of a single ready-to-use vial by Sanofi-Aventis, presentation also used for generics. In this study, different available formulations were compared (Sanofi 2 vials, Sanofi 1 vial, Accord Healthcare, Kabi, Hospira) in terms of composition compliance with control specifications and simulated micelle behaviour to try to determine what could be the potential causes of this problem...
June 26, 2020: European Journal of Cancer