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Expandable sheath or e-sheath

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https://www.readbyqxmd.com/read/29720369/genomic-status-of-met-potentiates-sensitivity-to-met-and-mek-inhibition-in-nf1-related-malignant-peripheral-nerve-sheath-tumors
#1
Jacqueline D Peacock, Matthew G Pridgeon, Elizabeth A Tovar, Curt J Essenburg, Megan J Bowman, Zachary B Madaj, Julie Koeman, Elissa A Boguslawski, Jamie Grit, Rebecca D Dodd, Vadim Khachaturov, Diana M Cardona, Mark Chen, David G Kirsch, Flavio Maina, Rosanna Dono, Mary E Winn, Carrie R Graveel, Matthew R Steensma
Malignant Peripheral Nerve Sheath Tumors (MPNSTs) are highly resistant sarcomas that occur in up to 13% of individuals with Neurofibromatosis Type 1 (NF1). Genomic analysis of longitudinally collected tumor samples in a case of MPNST disease progression revealed early hemizygous microdeletions in NF1 and TP53, with progressive amplifications of MET, HGF, and EGFR. To examine the role of MET in MPNST progression, we developed mice with enhanced MET expression and Nf1 ablation (Nf1fl/KO;lox-stop-loxMETtg/+;Plp-creERTtg/+; referred to as NF1 MET)...
May 2, 2018: Cancer Research
https://www.readbyqxmd.com/read/29704639/proteomic-analysis-of-age-related-changes-in-ovine-cerebrospinal-fluid
#2
Carl P C Chen, Jane E Preston, Shaobo Zhou, Heidi R Fuller, David G A Morgan, Ruoli Chen
Cerebrospinal fluid (CSF) circulates through the brain and has a unique composition reflecting the biological processes of the brain. Identifying ageing CSF biomarkers can aid in understanding the ageing process and interpreting CSF protein changes in neurodegenerative diseases. In this study, ovine CSF proteins from young (1-2 year old), middle aged (3-6 year old) and old (7-10 year old) sheep were systemically studied. CSF proteins were labelled with iTRAQ tagging reagents and fractionated by 2-dimensional high performance, liquid chromatography...
April 25, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29703437/incidence-predictors-and-impact-of-vascular-complications-after-transfemoral-transcatheter-aortic-valve-implantation-with-the-sapien-3-prosthesis
#3
Floortje van Kesteren, Martijn S van Mourik, Jeroen Vendrik, Esther M A Wiegerinck, José P S Henriques, Karel T Koch, Joanna J Wykrzykowska, Rob J de Winter, Jan J Piek, Krijn P van Lienden, Jim A Reekers, M Marije Vis, R Nils Planken, Jan Baan
Vascular complications (VCs) after transfemoral transcatheter aortic valve implantation (TAVI) have always been reported to occur frequently. Studies addressing VCs have been conducted with older-generation prostheses. We aimed to evaluate the incidence, predictors, and impact of VCs after transfemoral TAVI with the balloon-expandable SAPIEN 3. We report a single-center retrospective analysis of 400 consecutive patients of a prospectively acquired cohort. All patients underwent transfemoral TAVI with SAPIEN 3 between January 2014 and December 2016...
May 15, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29699597/scanning-electron-microscopy-sem-energy-dispersive-x-ray-spectroscopy-eds-mapping-and-in-situ-observation-of-carbonization-of-culms-of-bambusa-multiplex
#4
Visittapong Yordsri, Chanchana Thanachayanont, Shunsuke Asahina, Yuuki Yamaguchi, Masahiro Kawasaki, Tetsuo Oikawa, Tadashi Nobuchi, Makoto Shiojiri
Green culms of bamboo and charcoal of Bambusa multiplex were investigated by scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDS) mapping. A dynamic observation of the initial stage of carbonization was also performed in-situ by heating a radial longitudinal section of the bamboo culm at a rate of 20°C/min up to 500°C. EDS mapping of the green bamboo culms detected Si signals in the harder cells such as the epidermis (Ep), cortex (Cor) and vascular bundle sheath (Bs) and between these cells as silicon oxide particles...
April 2018: Microscopy and Microanalysis
https://www.readbyqxmd.com/read/29689892/morphological-evidence-uncovers-a-new-species-of-goniurosaurus-squamata-eublepharidae-from-the-hainan-island-china
#5
Run-Bang Zhou, Ning Wang, Bei Chen, Bin Liang
A new species of the genus Goniurosaurus, G. zhoui sp. nov., is described based on specimens collected from karst areas in Hainan Island, China. Quantitative comparison of morphological traits and egg size with two known endemic species in Hainan Island and other known congeners confirmed the distinctiveness of G. zhoui sp. nov., which has a moderate size with a snout-vent length of 93.4-97.4 mm; light purple-brown dorsal ground color in adults; a posteriorly protracted nuchal loop on nape; four faint, purple-gray body bands bearing dark purple spots between and on them; eight nasal scales surrounding nares; single internasal; 49-62 eyelid fringe scales; 130-140 scales around midbody; 11 granular scales surrounding the dorsal tubercles; 36-38 precloacal pores in males (absent in females); claws sheathed by four scales, two lateral scales long and curved...
January 3, 2018: Zootaxa
https://www.readbyqxmd.com/read/29687397/review-of-dotocryptus-br%C3%A3-thes-hymenoptera-ichneumonidae-cryptinae-with-a-new-species-from-colombia
#6
B F Santos, A P Aguiar
The taxonomic limits of the Neotropical genus Dotocryptus Brèthes are reviewed. The genus is characterized mainly by the very long ovipositor, at least 2.2× as long as hind tibia; apex of ovipositor distinctly depressed, ventral valve expanded, and overlapping dorsal valve as a sheath; and mandible long with ventral tooth longer than dorsal one. A new species, Dotocryptus arcadius sp. nov., from Colombia is described and illustrated. The new species can be diagnosed mainly by the head and mesosoma with multiple whitish marks; epicnemial carina reaching 0...
April 23, 2018: Neotropical Entomology
https://www.readbyqxmd.com/read/29679713/molecular-phylogenetics-of-the-genus-costularia-schoeneae-cyperaceae-reveals-multiple-distinct-evolutionary-lineages
#7
Isabel Larridon, Kenneth Bauters, Ilias Semmouri, Jan-Adriaan Viljoen, Christina J Prychid, A Muthama Muasya, Jeremy J Bruhl, Karen L Wilson, Bruno Senterre, Paul Goetghebeur
We investigated the monophyly of Costularia (25 species), a genus of tribe Schoeneae (Cyperaceae) that illustrates a remarkable distribution pattern from southeastern Africa, over Madagascar, the Mascarenes and Seychelles, to Malesia and New Caledonia. A further species, Tetraria borneensis, has been suggested to belong to Costularia. Relationships and divergence times were inferred using an existing four marker phylogeny of Cyperaceae tribe Schoeneae expanded with newly generated sequence data mainly for Costularia s...
April 18, 2018: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/29546726/viral-transduction-of-schwann-cells-for-peripheral-nerve-repair
#8
Christine D Plant, Giles W Plant
Schwann cells are the primary inducers of regeneration of the peripheral nervous system. Schwann cells can be isolated from adult peripheral nerves, expanded in large numbers, and genetically transduced by viral vectors in vitro prior to their use in vivo. Here we describe how to use lentiviral vectors to transduce primary Schwann cells in vitro. We also describe how cultured Schwann cells can be used in conjunction with decellularized peripheral nerve sheaths prepared by multiple freeze thawing of peripheral nerve tissue...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29541838/broken-wings-first-reported-cases-of-fractured-angel-%C3%A2-catheters-a-temporary-combined-femoral-venous-catheter-and-retrievable-ivc-filter-device
#9
Mohammed Rashid Akhtar, Jimmy Kyaw Tun, Riad Alchanan, Ounali Jaffer, Snehal Patel, Joo-Young Chun, Nicholas Bunker, Tim Fotheringham
There has been increasing use of a novel combined femoral venous sheath, catheter and retrievable self-expanding and collapsible diamond-shaped IVC filter (Angel® Catheter, BiO2 Medical), in severely injured patients who cannot receive anticoagulation. As the filter is not detached from the catheter/sheath, it should be easily retrieved. Outcomes included in large registries demonstrate a high safety profile and a 100% retrieval rate. However, at our institution-a Level 1 major UK trauma centre with 4 years of substantial experience in using this device-we've encountered three cases of device fracture and subsequent complicated retrieval dating from Dec 2016 to March 2017...
March 14, 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29535017/hybrid-treatment-of-tandem-common-carotid-innominate-artery-and-ipsilateral-carotid-bifurcation-stenoses-by-simultaneous-retrograde-proximal-stenting-and-eversion-carotid-endarterectomy-preliminary-results-of-a-case-series
#10
Giulio Illuminati, Giulia Pizzardi, Rocco Pasqua, Francesca Frezzotti, Piergaspare Palumbo, Francesco Macrina, Francesco Calio'
BACKGROUND: Tandem stenoses of the internal carotid artery (ICA) and proximal, ipsilateral common carotid artery (CCA) or innominate artery can be treated with a hybrid approach, combining conventional carotid endarterectomy (CEA) and retrograde stenting of the proximal stenosis, through surgical exposure of the carotid bifurcation. The purpose of this study was to evaluate the results of combining eversion CEA with retrograde CCA/innominate artery stenting. MATERIAL AND METHODS: From January 2015 to July 2017, 7 patients, 6 men of a mean age of 72 years (range 59-83 years) underwent simultaneous, retrograde stenting of the proximal CCA/innominate artery and an eversion CEA of the ipsilateral ICA, through surgical exposure of the carotid bifurcation, for severe tandem stenoses...
April 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29523171/clinical-feasibility-of-umbilical-cord-tissue-derived-mesenchymal-stem-cells-in-the-treatment-of-multiple-sclerosis
#11
Neil H Riordan, Isabela Morales, Giselle Fernández, Nicole Allen, Neal E Fearnot, Michael E Leckrone, Dedra Jones Markovich, Darla Mansfield, Dorita Avila, Amit N Patel, Santosh Kesari, Jorge Paz Rodriguez
BACKGROUND: Multiple sclerosis (MS) is a progressively debilitating neurological condition in which the immune system abnormally erodes the myelin sheath insulating the nerves. Mesenchymal stem cells (MSC) have been used in the last decade to safely treat certain immune and inflammatory conditions. METHODS: A safety and feasibility study was completed on the use of umbilical cord MSC (UCMSC) as a treatment for MS. In this 1-year study, consenting subjects received seven intravenous infusions of 20 × 106 UCMSC over 7 days...
March 9, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29455410/can-patients-with-symptomatic-tarlov-cysts-be-differentiated-from-patients-with-specific-low-back-pain-based-on-comprehensive-history-taking
#12
Maria Anna Hulens, Wim Dankaerts, Ricky Rasschaert, Frans Bruyninckx, Marie-Laure Willaert, Charlotte Vereecke, Greet Vansant
BACKGROUND: Tarlov cysts (TCs) are expanded nerve root sheaths that occur near the dorsal root ganglion and result from increased intraspinal hydrostatic pressure. TCs most frequently affect the lumbosacral plexus and therefore may cause specific symptoms such as perineal pain and neurogenic bladder, bowel, and sphincter problems. It has been estimated that 1% of the population has symptomatic Tarlov cysts (STCs). However, STCs appear to be underdiagnosed, with the pain reported by patients commonly attributed to degenerative alterations seen on MRI...
April 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29421424/renal-fenestration-closure-technique-in-fenestrated-endovascular-repair-for-pararenal-aortic-aneurysm
#13
Enrico Gallitto, Mauro Gargiulo, Gianluca Faggioli, Alessia Sonetto, Chiara Mascoli, Rodolfo Pini, Mohamhed Abualhin, Andrea Stella
PURPOSE: To describe an endovascular technique to close a renal artery fenestration during fenestrated endograft implant for a pararenal abdominal aortic aneurysm (p-AAA) without interfering with other visceral vessels. REPORT: A 76-year-old man with p-AAA underwent repair by a 4 fenestrations custom-made endograft. At the intraprocedural angiography, the right renal artery was occluded. To avoid a high-flow endoleak from fenestration, we performed the following technique: a 9F-steerable sheath was used to advance a 7F sheath through the fenestration into aneurism...
February 5, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29321492/quantification-of-silver-nanoparticle-toxicity-to-algae-in-soil-via-photosynthetic-and-flow-cytometric-analyses
#14
Sun-Hwa Nam, Jin Il Kwak, Youn-Joo An
Soil algae, which have received attention for their use in a novel bioassay to evaluate soil toxicity, expand the range of terrestrial test species. However, there is no information regarding the toxicity of nanomaterials to soil algae. Thus, we evaluated the effects of silver nanoparticles (0-50 mg AgNPs/kg dry weight soil) on the soil alga Chlamydomonas reinhardtii after six days, and assessed changes in biomass, photosynthetic activity, cellular morphology, membrane permeability, esterase activity, and oxidative stress...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29291290/minimally-invasive-approach-to-resection-of-paraspinal-schwannoma
#15
Patrick Paullus, Taylor A Wilson, Paul Lee, Arunprasad Gunasekaran, Noojan Kazemi
In this video, the authors demonstrate a minimally invasive approach and resection of a paraspinal schwannoma. Using an expandable retractor, the authors were able to identify important adjacent bony landmarks and hence visualize and remove this peripheral nerve sheath tumor. While a tubular retractor is commonly used for interbody fusion procedures, the location of the tumor allowed this minimally invasive approach resulting in excellent access, minimal soft-tissue injury, and a short hospital stay. The authors present this approach as a less invasive and yet effective technique for resection of otherwise difficult-to-access nerve lesions...
January 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29246097/neurofibromatosis-clinical-trial-consortium
#16
Roger J Packer, Michael J Fisher, Gary Cutter, Karen Cole-Plourde, Bruce R Korf
Neurofibromatosis type 1 and type 2, affecting both children and adults, often results in devastating complications. The rapid unravelling of the genetic underpinnings of these unique disorders has led to the development of novel therapies, especially molecular-targeted therapies. To facilitate clinical trial development, the Neurofibromatosis Clinical Trial Consortium (NFCTC) was established in 2006 by the Department of Defense. Over the past decade, the Consortium has successfully completed studies for children and adults with neurofibromatosis type 1 and plexiform neurofibromas, neurocognitive challenges, low-grade gliomas, and malignant peripheral nerve sheath tumors...
January 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/29239225/ureteroscopic-high-frequency-dusting-utilizing-a-120-w-holmium-laser
#17
James Tracey, Galina Gagin, Duncan Morhardt, John Hollingsworth, Khurshid R Ghani
INTRODUCTION AND OBJECTIVE: Recently there has been interest in a dusting technique for lithotripsy during ureteroscopy (URS) utilizing high-frequency and low-pulse energy (HiFr-LoPE) settings. We assessed a 120 W holmium laser that permits high-frequency (>50 Hz) dusting. MATERIALS AND METHODS: Consecutive URS cases performed by a single surgeon using the P120H (Lumenis, San Jose, CA) were reviewed. Lithotripsy was performed using HiFr-LoPE settings (50-80 Hz/0...
January 17, 2018: Journal of Endourology
https://www.readbyqxmd.com/read/29189831/-newer-generation-self-expandable-coronary-stent-bail-out-re-sheathing
#18
Alberto Barioli, Massimo Napodano, Giuseppe Tarantini
Newer generation of self-expandable nitinol coronary stents has proven to be useful in the treatment of bifurcations, tapered vessels, thrombotic lesions, venous grafts and ectatic segments. However, optimal device positioning can be cumbersome, due to the peculiar delivery mechanism which consists of retracting an outer sheath in order to release the stent from the distal edge. We report the case of a 53-year-old man, admitted for unstable angina. Coronary angiography showed a tight stenosis of the proximal left anterior descending coronary artery...
December 2017: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/29151117/risks-of-flexible-ureterorenoscopy-pathophysiology-and-prevention
#19
REVIEW
Palle J S Osther
Currently, indications for flexible ureterorenoscopy (fURS) are expanding, mainly due to technological advancements. Although data from clinical series definitely presents fURS as a safe procedure, serious complications including sepsis and ureteral lesions do occur. These complications seem to be a result of the unique elements of fURS, ureteral access and irrigation, pushing normal upper urinary tract physiology into pathophysiological processes, including intrarenal/pyelo-veneous backflow and ureteral contractions, potentially resulting in septic, haemorrhagic and ureteral lesional complications...
February 2018: Urolithiasis
https://www.readbyqxmd.com/read/29138631/sarc006-phase-ii-trial-of-chemotherapy-in-sporadic-and-neurofibromatosis-type-1-associated-chemotherapy-naive-malignant-peripheral-nerve-sheath-tumors
#20
Christine S Higham, Seth M Steinberg, Eva Dombi, Arie Perry, Lee J Helman, Scott M Schuetze, Joseph A Ludwig, Arthur Staddon, Mohammed M Milhem, Daniel Rushing, Robin L Jones, Michael Livingston, Stewart Goldman, Christopher Moertel, Lars Wagner, David Janhofer, Christina M Annunziata, Denise Reinke, Lauren Long, David Viskochil, Larry Baker, Brigitte C Widemann
Background: Worse chemotherapy response for neurofibromatosis type 1- (NF1-) associated compared to sporadic malignant peripheral nerve sheath tumors (MPNST) has been reported. Methods: We evaluated the objective response (OR) rate of patients with AJCC Stage III/IV chemotherapy-naive NF1 MPNST versus sporadic MPNST after 4 cycles of neoadjuvant chemotherapy, 2 cycles of ifosfamide/doxorubicin, and 2 cycles of ifosfamide/etoposide. A Simon optimal two-stage design was used (target response rate 40%)...
2017: Sarcoma
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