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Rapid prototype heart valve

Peyman Sardari Nia, Samuel Heuts, Jean Daemen, Peter Luyten, Jindrich Vainer, Jan Hoorntje, Emile Cheriex, Jos Maessen
OBJECTIVES: Mitral valve repair performed by an experienced surgeon is superior to mitral valve replacement for degenerative mitral valve disease; however, many surgeons are still deterred from adapting this procedure because of a steep learning curve. Simulation-based training and planning could improve the surgical performance and reduce the learning curve. The aim of this study was to develop a patient-specific simulation for mitral valve repair and provide a proof of concept of personalized medicine in a patient prospectively planned for mitral valve surgery...
September 27, 2016: Interactive Cardiovascular and Thoracic Surgery
Boris Schmitt, Hendrik Spriestersbach, Darach O H-Icí, Torben Radtke, Marco Bartosch, Heiner Peters, Matthias Sigler, Laura Frese, Petra E Dijkman, Frank P T Baaijens, Simon P Hoerstrup, Felix Berger
AIMS: The objective was to implant a stented decellularised tissue-engineered heart valve (sdTEHV) percutaneously in an animal model, to assess its in vivo functionality and to examine the repopulation and remodelling of the valvular matrix by the recipient's autologous cells. METHODS AND RESULTS: Prototypes of sdTEHV were cultured in vitro, decellularised and percutaneously implanted into the pulmonary position in 15 sheep. Functionality was assessed monthly by intracardiac echocardiography (ICE)...
May 17, 2016: EuroIntervention
Ramón Rodríguez-Olivares, Nahid El Faquir, Zouhair Rahhab, Anne-Marie Maugenest, Nicolas M Van Mieghem, Carl Schultz, Guenter Lauritsch, Peter P T de Jaegere
To study the determinants of image quality of rotational angiography using dedicated research prototype software for motion compensation without rapid ventricular pacing after the implantation of four commercially available catheter-based valves. Prospective observational study including 179 consecutive patients who underwent transcatheter aortic valve implantation (TAVI) with either the Medtronic CoreValve (MCS), Edward-SAPIEN Valve (ESV), Boston Sadra Lotus (BSL) or Saint-Jude Portico Valve (SJP) in whom rotational angiography (R-angio) with motion compensation 3D image reconstruction was performed...
July 2016: International Journal of Cardiovascular Imaging
Laura J Olivieri, Axel Krieger, Yue-Hin Loke, Dilip S Nath, Peter C W Kim, Craig A Sable
BACKGROUND: With the advent of three-dimensional (3D) printers and high-resolution cardiac imaging, rapid prototype constructions of congenital cardiac defects are now possible. Typically, source images for these models derive from higher resolution, cross-sectional cardiac imaging, such as cardiac magnetic resonance imaging or computed tomography. These imaging methods may involve intravenous contrast, sedation, and ionizing radiation. New echocardiographic transducers and advanced software and hardware have optimized 3D echocardiographic images for this purpose...
April 2015: Journal of the American Society of Echocardiography
Andrea Amerini, Nima Hatam, Margarita Malasa, Desiree Pott, Lachmandath Tewarie, Peter Isfort, Andreas Goetzenich, Martin Hildinger, Rüdiger Autschbach, Jan Spillner
OBJECTIVES: Interventional treatment of tricuspid valve disease has so far received little attention due to the anatomical challenges in a thrombogenic surrounding. In the present study, we present an imaging-based, personalized interventional approach to the therapy of tricuspid regurgitation. METHODS: In our porcine model, we used rapid prototyping to build a matrix reproducing the geometry of the right atrium that was previously derived from computer tomography (CT) scans...
September 2014: Interactive Cardiovascular and Thoracic Surgery
Ricardo Moreira, Valentine N Gesche, Luis G Hurtado-Aguilar, Thomas Schmitz-Rode, Julia Frese, Stefan Jockenhoevel, Petra Mela
Mitral valve regurgitation together with aortic stenosis is the most common valvular heart disease in Europe and North America. Mechanical and biological prostheses available for mitral valve replacement have significant limitations such as the need of a long-term anticoagulation therapy and failure by calcifications. Both types are unable to remodel, self-repair, and adapt to the changing hemodynamic conditions. Moreover, they are mostly designed for the aortic position and do not reproduce the native annular-ventricular continuity, resulting in suboptimal hemodynamics, limited durability, and gradually decreasing ventricular pumping efficiency...
September 2014: Tissue Engineering. Part C, Methods
Tom Treasure, Johanna J M Takkenberg, Tal Golesworthy, Filip Rega, Mario Petrou, Ulrich Rosendahl, Raad Mohiaddin, Michael Rubens, Warren Thornton, Belinda Lees, John Pepper
OBJECTIVE: Among people with Marfan syndrome who have a typical aortic root aneurysm, dissection is a characteristic cause of premature death. To pre-empt Type A dissection, composite root replacement with a mechanical valve became the standard of care in the 1980s and 1990s. This is being superseded by valve-sparing aortic root replacement to avoid lifelong anticoagulation. In 2004, a total root and valve-sparing procedure, personalised external aortic support, was introduced. We report here results among the first 30 recipients...
June 2014: Heart: Official Journal of the British Cardiac Society
Pei-Hsiu Huang, Andrew C Eisenhauer
Transcatheter aortic valve replacement has a place in the therapy for valvular aortic stenosis in a selected population of patients with increased risk for standard aortic valve replacement. The SAPIEN family of balloon-expandable transcatheter heart valves is the prototype that initiated this therapy and has undergone rapid development and evolution. The SAPIEN system has taught cardiologists and cardiac surgeons much about the nature of aortic stenosis and the potential for less invasive therapy. This article will review the SAPIEN transcatheter heart valves and the clinical experience...
August 2013: Cardiology Clinics
Ralf Brecht, Maximilian Friedrich, Paul Philipp Heinisch, Katharina Plonien, Bassil Akra, Christian Hagl, Ali Khoynezhad, Georg Lutter, René Bombien
OBJECTIVE: Transcatheter aortic valve implantation gained clinical relevance with an impressive and peerless power; however, the procedure induces unsolved complications such as paravalvular leakage, occlusion of coronary ostia, and vascular complications. The safe removal of bulky calcified valves will improve the outcome, well known through the open surgical procedure. In this article, a new stapler-based resection and implantation device as well as a new approach for valve isolation during normal heart cycle without extracorporeal circulation will be analyzed...
January 2013: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
Giovanni Biglino, Peter Verschueren, Raf Zegels, Andrew M Taylor, Silvia Schievano
BACKGROUND: Compliant vascular phantoms are desirable for in-vitro patient-specific experiments and device testing. TangoPlus FullCure 930 is a commercially available rubber-like material that can be used for PolyJet rapid prototyping. This work aims to gather preliminary data on the distensibility of this material, in order to assess the feasibility of its use in the context of experimental cardiovascular modelling. METHODS: The descending aorta anatomy of a volunteer was modelled in 3D from cardiovascular magnetic resonance (CMR) images and rapid prototyped using TangoPlus...
2013: Journal of Cardiovascular Magnetic Resonance
Giovanni Biglino, Alessandro Giardini, Catriona Baker, Richard S Figliola, Tain-Yen Hsia, Andrew M Taylor, Silvia Schievano
This study describes the implementation of an experimental model of the "Sano" variant (right-ventricle to pulmonary-artery shunt) of the Norwood operation used to treat hypoplastic left-heart syndrome (HLHS). The Sano operation is an alternative to the modified Blalock-Taussig shunt (innominate to pulmonary artery shunt). In the experimental setup, the single ventricle is simulated using a Berlin Heart Excor ventricular assist device and the Sano shunt is constructed by attaching a Tygon tube (6 mm internal diameter, 40 mm long) to the perforated de-airing valve of the Berlin Heart at one end, and to a pulmonary compliance chamber at the other end...
January 2013: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Ronald K Binder, Josep Rodés-Cabau, David A Wood, John G Webb
Building on the established success with the SAPIEN, SAPIEN XT and earlier prototypic transcatheter heart valves (THV) the newest balloon-expandable valve incorporates a number of new and enhanced features intended to reduce the risk of vascular injury, to reduce paravalvular regurgitation, and to facilitate rapid and accurate positioning and implantation. The SAPIEN 3 THV incorporates a cobalt chromium stent, bovine pericardial leaflets, and both an inner and new outer polyethylene terephthalate sealing cuff...
September 2012: EuroIntervention
Alexandrina Untariou, Paul E Allaire
Ventricular assist devices (VADs) have been developed to augment the deteriorating heart function of those suffering from end-stage congestive heart failure. While these devices have the potential to extend the life span and improve the quality of life of their recipients, they are also susceptible to mechanical failure. In the case of many known VADs, pump failure allows blood to flow retrograde through the device leading to a rapid loss of systemic pressure and loss of life. Some devices, such as heart valves, have been implemented to reduce or eliminate the potential for backflow in VADs but almost always at the expense of making the system more prone to thromboembolism or less reliable overall...
2012: Biomedical Sciences Instrumentation
Giovanni Biglino, Claudio Capelli, Alia Binazzi, Rita Reggiani, Daria Cosentino, Francesco Migliavacca, Philipp Bonhoeffer, Andrew M Taylor, Silvia Schievano
AIMS: To validate patient-specific computational testing of a second-generation device for percutaneous pulmonary valve implantation (PPVI), against realistic in vitro data. METHODS AND RESULTS: Tests were initially carried out in a simple loading mode, performing a compliance test on a rapid prototyped cylinder. This model was reproduced computationally and validated against the experimental data. A second-generation PPVI stent-graft, with no valve mounted, was then deployed in a simplified cylindrical geometry, measuring its displacement when subjected to a pressure pulse...
May 15, 2012: EuroIntervention
Alain Cribier
The development of transcatheter aortic valve implantation (TAVI) by our group has been a 20-year odyssey. In 1993, postmortem studies validated the concept of intravalvular stenting in calcific aortic stenosis. The first prototypes of balloon-expandable valves were tested in an animal model in 2000. The first-in-man implantation was performed in Rouen in 2002, rapidly followed by two prospective series in compassionate cases in our centre. TAVI took flight in 2004 in the hands of Edwards Lifesciences, with major improvements in devices and approaches...
March 2012: Archives of Cardiovascular Diseases
Tarun Garg, Onkar Singh, Saahil Arora, R Murthy
Scaffolds are implants or injects, which are used to deliver cells, drugs, and genes into the body. Different forms of polymeric scaffolds for cell/drug delivery are available: (1) a typical three-dimensional porous matrix, (2) a nanofibrous matrix, (3) a thermosensitive sol-gel transition hydrogel, and (4) a porous microsphere. A scaffold provides a suitable substrate for cell attachment, cell proliferation, differentiated function, and cell migration. Scaffold matrices can be used to achieve drug delivery with high loading and efficiency to specific sites...
2012: Critical Reviews in Therapeutic Drug Carrier Systems
Manuel K Rausch, Wolfgang Bothe, John-Peder Escobar Kvitting, Julia C Swanson, Neil B Ingels, D Craig Miller, Ellen Kuhl
The objective of this study is to establish a mathematical characterization of the mitral valve annulus that allows a precise qualitative and quantitative assessment of annular dynamics in the beating heart. We define annular geometry through 16 miniature markers sewn onto the annuli of 55 sheep. Using biplane videofluoroscopy, we record marker coordinates in vivo. By approximating these 16 marker coordinates through piecewise cubic splines, we generate a smooth mathematical representation of the 55 mitral annuli...
June 2011: Annals of Biomedical Engineering
Silvia Schievano, Andrew M Taylor, Claudio Capelli, Louise Coats, Fiona Walker, Philipp Lurz, Johannes Nordmeyer, Sue Wright, Sachin Khambadkone, Victor Tsang, Mario Carminati, Philipp Bonhoeffer
AIMS: To present our experience of 'first-in-man' implantation of a new percutaneous pulmonary valve into a dilated pulmonary trunk, using patient specific data to influence the design of the device and ensure patient safety. METHODS AND RESULTS: A 42-year-old with severe pulmonary insufficiency underwent computed tomography assessment of his pulmonary trunk. This information was utilised to create computer and rapid prototyping models that were used to customise and test the device, which was subsequently implanted into the patient...
January 2010: EuroIntervention
Andrés Díaz Lantada, Raquel Del Valle-Fernández, Pilar Lafont Morgado, Julio Muñoz-García, José Luis Muñoz Sanz, Juan Manuel Munoz-Guijosa, Javier Echávarri Otero
Although the use of personalized annuloplasty rings manufactured for each patient according to the size and morphology of their valve complex could be beneficial for the treatment of mitral insufficiency, this possibility has been limited for reasons of time-lines and costs as well as for design and manufacturing difficulties, as has been the case with other personalized implant and prosthetic developments. However, the present quality of medical image capture equipment together with the benefits to be had from computer-aided design and manufacturing technologies (CAD-CAM) and the capabilities furnished by rapid prototyping technologies, present new opportunities for a personalized response to the development of implants and prostheses, the social impact of which could turn out to be highly positive...
February 2010: Annals of Biomedical Engineering
Yos S Morsi, Ian Birchall
Valvular heart disease is an important cause of morbidity and mortality, and currently available substitutes for failing hearts have serious limitations. A new promising alternative that may overcome these shortcomings is provided by the relatively new field of tissue engineering (TE). TE techniques involve the growth of autologous cells on a 3D matrix that can be a biodegradable polymer scaffold, or an acellular tissue matrix. These approaches provide the potential to create living matrix valve structures with an ability to grow, repair and remodel within the recipient...
May 2005: Future Cardiology
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