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3D printed heart valve

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https://www.readbyqxmd.com/read/27677879/preoperative-planning-with-three-dimensional-reconstruction-of-patient-s-anatomy-rapid-prototyping-and-simulation-for-endoscopic-mitral-valve-repair
#1
Peyman Sardari Nia, Samuel Heuts, Jean Daemen, Peter Luyten, Jindrich Vainer, Jan Hoorntje, Emile Cheriex, Jos Maessen
OBJECTIVES: Mitral valve repair performed by an experienced surgeon is superior to mitral valve replacement for degenerative mitral valve disease; however, many surgeons are still deterred from adapting this procedure because of a steep learning curve. Simulation-based training and planning could improve the surgical performance and reduce the learning curve. The aim of this study was to develop a patient-specific simulation for mitral valve repair and provide a proof of concept of personalized medicine in a patient prospectively planned for mitral valve surgery...
September 27, 2016: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/27324801/3d-printed-modeling-of-the-mitral-valve-for-catheter-based-structural-interventions
#2
Marija Vukicevic, Daniel S Puperi, K Jane Grande-Allen, Stephen H Little
As catheter-based structural heart interventions become increasingly complex, the ability to effectively model patient-specific valve geometry as well as the potential interaction of an implanted device within that geometry will become increasingly important. Our aim with this investigation was to combine the technologies of high-spatial resolution cardiac imaging, image processing software, and fused multi-material 3D printing, to demonstrate that patient-specific models of the mitral valve apparatus could be created to facilitate functional evaluation of novel trans-catheter mitral valve repair strategies...
June 20, 2016: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/27149367/cardiothoracic-applications-of-3-dimensional-printing
#3
Andreas A Giannopoulos, Michael L Steigner, Elizabeth George, Maria Barile, Andetta R Hunsaker, Frank J Rybicki, Dimitris Mitsouras
Medical 3-dimensional (3D) printing is emerging as a clinically relevant imaging tool in directing preoperative and intraoperative planning in many surgical specialties and will therefore likely lead to interdisciplinary collaboration between engineers, radiologists, and surgeons. Data from standard imaging modalities such as computed tomography, magnetic resonance imaging, echocardiography, and rotational angiography can be used to fabricate life-sized models of human anatomy and pathology, as well as patient-specific implants and surgical guides...
September 2016: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/27142402/clinical-application-and-multidisciplinary-assessment-of-three-dimensional-printing-in-double-outlet-right-ventricle-with-remote-ventricular-septal-defect
#4
Swati Garekar, Alpa Bharati, Manish Chokhandre, Shivaji Mali, Bhadra Trivedi, Vishal P Changela, Narayan Solanki, Sarang Gaikwad, Vijay Agarwal
BACKGROUND: Double outlet right ventricle (DORV) with two well-developed ventricles and with a remote ventricular septal defect (VSD) may present a therapeutic challenge. Echocardiographic imaging of such complex cases does not always provide all of the information required to decide on an operative approach (biventricular or univentricular) and to design an intracardiac baffle to direct left ventricular outflow through the VSD and to the aorta for biventricular repair. A three dimensional (3D) printed model of the heart based upon data derived from computed tomography (CT) or magnetic resonance imaging (MRI) may contribute to a more complete appreciation of the intracardiac anatomy...
May 2016: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/27106636/optimizing-photo-encapsulation-viability-of-heart-valve-cell-types-in-3d-printable-composite-hydrogels
#5
Laura Hockaday Kang, Patrick A Armstrong, Lauren Julia Lee, Bin Duan, Kevin Heeyong Kang, Jonathan Talbot Butcher
Photocrosslinking hydrogel technologies are attractive for the biofabrication of cardiovascular soft tissues, but 3D printing success is dependent on multiple variables. In this study we systematically test variables associated with photocrosslinking hydrogels (photoinitiator type, photoinitiator concentration, and light intensity) for their effects on encapsulated cells in an extrusion 3D printable mixture of methacrylated gelatin/poly-ethylene glycol diacrylate/alginate (MEGEL/PEGDA3350/alginate). The fabrication conditions that produced desired hydrogel mechanical properties were compared against those that optimize aortic valve or mesenchymal stem cell viability...
April 22, 2016: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/27066785/state-of-the-art-review-of-3d-bioprinting-for-cardiovascular-tissue-engineering
#6
Bin Duan
3D bioprinting is a group of rapidly growing techniques that allows building engineered tissue constructs with complex and hierarchical structures, mechanical and biological heterogeneity. It enables implementation of various bioinks through different printing mechanisms and precise deposition of cell and/or biomolecule laden biomaterials in predefined locations. This review briefly summarizes applicable bioink materials and various bioprinting techniques, and presents the recent advances in bioprinting of cardiovascular tissues, with focusing on vascularized constructs, myocardium and heart valve conduits...
April 11, 2016: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/26758411/calcium-distribution-patterns-of-the-aortic-valve-as-a-risk-factor-for-the-need-of-permanent-pacemaker-implantation-after-transcatheter-aortic-valve-implantation
#7
Buntaro Fujita, Maximilian Kütting, Moritz Seiffert, Smita Scholtz, Sandrine Egron, Emir Prashovikj, Jochen Börgermann, Timm Schäfer, Werner Scholtz, Rainer Preuss, Jan Gummert, Ulrich Steinseifer, Stephan M Ensminger
AIMS: New-onset conduction disturbances still represent a considerable problem after transcatheter aortic valve implantation (TAVI). The aim of this study was to identify calcification patterns with an elevated risk for permanent pacemaker implantation (PPI) after TAVI and investigate underlying mechanisms in an ex vivo setting. METHODS AND RESULTS: One hundred and sixty-two patients who underwent TAVI with the Edwards SAPIEN XT(®) or Medtronic CoreValve(®) at our institution were analysed...
January 12, 2016: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/26071991/three-dimensional-printing-for-in%C3%A2-vivo-visualization-of-his-bundle-pacing-leads
#8
Terry Bauch, Pugazhendhi Vijayaraman, Gopi Dandamudi, Kenneth Ellenbogen
Transvenous pacing leads have been implicated in tricuspid valve dysfunction, and our group has adopted routine use of His bundle pacing to mitigate this effect. Three-dimensional (3D) printing technology holds great promise for advancing medicine, but the high start-up costs can be a deterrent. Seeking confirmation of optimal lead placement relative to the tricuspid annulus, we used low-cost commercial and public domain technologies to generate 3D-printed hearts from selected patients with His bundle pacing leads...
August 1, 2015: American Journal of Cardiology
https://www.readbyqxmd.com/read/25847966/development-of-an-algorithm-to-plan-and-simulate-a-new-interventional-procedure
#9
Buntaro Fujita, Maximilian Kütting, Smita Scholtz, Marc Utzenrath, Kavous Hakim-Meibodi, Lech Paluszkiewicz, Christoph Schmitz, Jochen Börgermann, Jan Gummert, Ulrich Steinseifer, Stephan Ensminger
OBJECTIVES: The number of implanted biological valves for treatment of valvular heart disease is growing and a percentage of these patients will eventually undergo a transcatheter valve-in-valve (ViV) procedure. Some of these patients will represent challenging cases. The aim of this study was to develop a feasible algorithm to plan and in vitro simulate a new interventional procedure to improve patient outcome. METHODS: In addition to standard diagnostic routine, our algorithm includes 3D printing of the annulus, hydrodynamic measurements and high-speed analysis of leaflet kinematics after simulation of the procedure in different prosthesis positions as well as X-ray imaging of the most suitable valve position to create a 'blueprint' for the patient procedure...
July 2015: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/25775166/current-progress-in-3d-printing-for-cardiovascular-tissue-engineering
#10
REVIEW
Bobak Mosadegh, Guanglei Xiong, Simon Dunham, James K Min
3D printing is a technology that allows the fabrication of structures with arbitrary geometries and heterogeneous material properties. The application of this technology to biological structures that match the complexity of native tissue is of great interest to researchers. This mini-review highlights the current progress of 3D printing for fabricating artificial tissues of the cardiovascular system, specifically the myocardium, heart valves, and coronary arteries. In addition, how 3D printed sensors and actuators can play a role in tissue engineering is discussed...
June 2015: Biomedical Materials
https://www.readbyqxmd.com/read/25663505/tissue-engineering-applications-of-three-dimensional-bioprinting
#11
Xiaoying Zhang, Yangde Zhang
Recent advances in tissue engineering have adapted the additive manufacturing technology, also known as three-dimensional printing, which is used in several industrial applications, for the fabrication of bioscaffolds and viable tissue and/or organs to overcome the limitations of other in vitro conventional methods. 3D bioprinting technology has gained enormous attention as it enabled 3D printing of a multitude of biocompatible materials, different types of cells and other supporting growth factors into complex functional living tissues in a 3D format...
July 2015: Cell Biochemistry and Biophysics
https://www.readbyqxmd.com/read/25660668/three-dimensional-printing-of-intracardiac-defects-from-three-dimensional-echocardiographic-images-feasibility-and-relative-accuracy
#12
Laura J Olivieri, Axel Krieger, Yue-Hin Loke, Dilip S Nath, Peter C W Kim, Craig A Sable
BACKGROUND: With the advent of three-dimensional (3D) printers and high-resolution cardiac imaging, rapid prototype constructions of congenital cardiac defects are now possible. Typically, source images for these models derive from higher resolution, cross-sectional cardiac imaging, such as cardiac magnetic resonance imaging or computed tomography. These imaging methods may involve intravenous contrast, sedation, and ionizing radiation. New echocardiographic transducers and advanced software and hardware have optimized 3D echocardiographic images for this purpose...
April 2015: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/25063052/rapid-manufacturing-techniques-for-the-tissue-engineering-of-human-heart-valves
#13
Cora Lueders, Ben Jastram, Roland Hetzer, Hartmut Schwandt
Three-dimensional (3D) printing technologies have reached a level of quality that justifies considering rapid manufacturing for medical applications. Herein, we introduce a new approach using 3D printing to simplify and improve the fabrication of human heart valve scaffolds by tissue engineering (TE). Custom-made human heart valve scaffolds are to be fabricated on a selective laser-sintering 3D printer for subsequent seeding with vascular cells from human umbilical cords. The scaffolds will be produced from resorbable polymers that must feature a number of specific properties: the structure, i...
October 2014: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/24334142/three-dimensional-printed-trileaflet-valve-conduits-using-biological-hydrogels-and-human-valve-interstitial-cells
#14
B Duan, E Kapetanovic, L A Hockaday, J T Butcher
Tissue engineering has great potential to provide a functional de novo living valve replacement, capable of integration with host tissue and growth. Among various valve conduit fabrication techniques, three-dimensional (3-D) bioprinting enables deposition of cells and hydrogels into 3-D constructs with anatomical geometry and heterogeneous mechanical properties. Successful translation of this approach, however, is constrained by the dearth of printable and biocompatible hydrogel materials. Furthermore, it is not known how human valve cells respond to these printed environments...
May 2014: Acta Biomaterialia
https://www.readbyqxmd.com/read/23324211/rapid-prototyping-compliant-arterial-phantoms-for-in-vitro-studies-and-device-testing
#15
Giovanni Biglino, Peter Verschueren, Raf Zegels, Andrew M Taylor, Silvia Schievano
BACKGROUND: Compliant vascular phantoms are desirable for in-vitro patient-specific experiments and device testing. TangoPlus FullCure 930 is a commercially available rubber-like material that can be used for PolyJet rapid prototyping. This work aims to gather preliminary data on the distensibility of this material, in order to assess the feasibility of its use in the context of experimental cardiovascular modelling. METHODS: The descending aorta anatomy of a volunteer was modelled in 3D from cardiovascular magnetic resonance (CMR) images and rapid prototyped using TangoPlus...
January 16, 2013: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/23015540/3d-bioprinting-of-heterogeneous-aortic-valve-conduits-with-alginate-gelatin-hydrogels
#16
Bin Duan, Laura A Hockaday, Kevin H Kang, Jonathan T Butcher
Heart valve disease is a serious and growing public health problem for which prosthetic replacement is most commonly indicated. Current prosthetic devices are inadequate for younger adults and growing children. Tissue engineered living aortic valve conduits have potential for remodeling, regeneration, and growth, but fabricating natural anatomical complexity with cellular heterogeneity remain challenging. In the current study, we implement 3D bioprinting to fabricate living alginate/gelatin hydrogel valve conduits with anatomical architecture and direct incorporation of dual cell types in a regionally constrained manner...
May 2013: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/19282321/a-new-training-set-up-for-trans-apical-aortic-valve-replacement
#17
Philippe Abdel-Sayed, Martins Kalejs, Ludwig Karl von Segesser
Trans-apical aortic valve replacement (AVR) is a new and rapidly growing therapy. However, there are only few training opportunities. The objective of our work is to build an appropriate artificial model of the heart that can replace the use of animals for surgical training in trans-apical AVR procedures. To reduce the necessity for fluoroscopy, we pursued the goal of building a translucent model of the heart that has nature-like dimensions. A simplified 3D model of a human heart with its aortic root was created in silico using the SolidWorks Computer-Aided Design (CAD) program...
June 2009: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/17925319/3d-imaging-of-cardiac-structures-using-3d-heart-models-for-planning-in-heart-surgery-a-preliminary-study
#18
Stephan Jacobs, Ronny Grunert, Friedrich W Mohr, Volkmar Falk
The aim of the study was to create an anatomical correct 3D rapid prototyping model (RPT) for patients with complex heart disease and altered geometry of the atria or ventricles to facilitate planning and execution of the surgical procedure. Based on computer tomography (CT) and magnetic resonance imaging (MRI) images, regions of interest were segmented using the Mimics 9.0 software (Materialise, Leuven, Belgium). The segmented regions were the target volume and structures at risk. After generating an STL-file (StereoLithography file) out of the patient's data set, the 3D printer Ztrade mark 510 (4D Concepts, Gross-Gerau, Germany) created a 3D plaster model...
February 2008: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/11107479/-physical-reproduction-of-cardiac-sutures-a-new-field-of-investigation-in-cardiology
#19
N Mirochnik, A Hagège, F Zacouto, C Guérot
A new technique of physical reproduction of cardiac anatomy has been developed from volumetric data and its practical value assessed in cardiological practice. The acquisition of the volumetric data was by 3D echocardiography. Parallel and equidistant 2D views were selected from this information. The images were printed at a scale adjusted to the true dimensions of the structures of interest and then stuck on a support, the thickness of which was identical to the distance between the views, and the slices were superimposed while respecting the initial orientation...
October 2000: Archives des Maladies du Coeur et des Vaisseaux
https://www.readbyqxmd.com/read/9950651/dynamic-holographic-imaging-of-the-beating-human-heart
#20
Hunziker, Smith, Scherrer-Crosbie, Liel-Cohen, Levine, Nesbitt, Benton, Picard
Background--Currently, the reporting and archiving of echocardiographic data suffer from the difficulty of representing heart motion on printable 2-dimensional (2D) media. Methods and Results--We studied the capability of holography to integrate motion into 2D echocardiographic prints. Images of normal human hearts and of a variety of mitral valve function abnormalities (mitral valve prolapse, systolic anterior motion of the mitral leaflets, and obstruction of the mitral valve by a myxoma) were acquired digitally on standard echocardiographic machines...
February 9, 1999: Circulation
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