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3D printed heart valve

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https://www.readbyqxmd.com/read/28971093/antimicrobial-peptides-in-biomedical-device-manufacturing
#1
REVIEW
Martijn Riool, Anna de Breij, Jan W Drijfhout, Peter H Nibbering, Sebastian A J Zaat
Over the past decades the use of medical devices, such as catheters, artificial heart valves, prosthetic joints, and other implants, has grown significantly. Despite continuous improvements in device design, surgical procedures, and wound care, biomaterial-associated infections (BAI) are still a major problem in modern medicine. Conventional antibiotic treatment often fails due to the low levels of antibiotic at the site of infection. The presence of biofilms on the biomaterial and/or the multidrug-resistant phenotype of the bacteria further impair the efficacy of antibiotic treatment...
2017: Frontiers in Chemistry
https://www.readbyqxmd.com/read/28854273/high-resolution-imaging-of-the-mitral-valve-in-the-natural-state-with-7-tesla-mri
#2
Sam E Stephens, Serguei Liachenko, Neil B Ingels, Jonathan F Wenk, Morten O Jensen
Imaging techniques of the mitral valve have improved tremendously during the last decade, but challenges persist. The delicate changes in annulus shape and papillary muscle position throughout the cardiac cycle have significant impact on the stress distribution in the leaflets and chords, thus preservation of anatomically accurate positioning is critical. The aim of this study was to develop an in vitro method and apparatus for obtaining high-resolution 3D MRI images of porcine mitral valves in both the diastolic and systolic configurations with physiologically appropriate annular shape, papillary muscle positions and orientations, specific to the heart from which the valve was harvested...
2017: PloS One
https://www.readbyqxmd.com/read/28736923/applications-of-additive-manufacturing-in-dentistry-a-review
#3
REVIEW
Aishwarya Bhargav, Vijayavenkatraman Sanjairaj, Vinicius Rosa, Lu Wen Feng, Jerry Fuh Yh
Additive manufacturing (AM) or 3D printing has been hailed as the third industrial revolution as it has caused a paradigm shift in the way objects have been manufactured. Conventionally, converting a raw material to a fully finished and assembled, usable product comprises several steps which can be eliminated by using this process as functional products can be created directly from the raw material at a fraction of the time originally consumed. Thus, AM has found applications in several sectors including automotive, aerospace, printed electronics, and healthcare...
July 24, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28721493/modelling-of-lesions-associated-with-functional-mitral-regurgitation-in-an-ex-vivo-platform
#4
Michal Jaworek, Federico Lucherini, Claudia Romagnoni, Guido Gelpi, Monica Contino, Paolo Romitelli, Carlo Antona, Gianfranco B Fiore, Riccardo Vismara
Functional mitral regurgitation (FMR) is a complex pathology involving valvular and subvalvular structures reconfiguration, and its treatment is considered challenging. There is a lack of experimental models allowing for reliable preclinical FMR treatments' evaluation in a realistic setting. A novel approach to simulate FMR was developed and incorporated into an ex vivo passive beating heart platform. FMR was obtained by dilating the mitral annulus (MA) mainly in the antero-posterior direction and displacing the papillary muscles (PMs) apically and laterally by ad hoc designed and 3D printed dilation and displacing devices...
July 18, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28444177/single-centre-experience-with-transapical-transcatheter-mitral-valve-implantation
#5
Gry Dahle, Kjell-Arne Rein, Arnt E Fiane
OBJECTIVES: A transcatheter heart valve technique can be used in failed mitral valve repairs with annuloplasty rings, deterioriated bioprostheses and in mitral annular calcification, all serving as 'docking stations' for balloon-expandable valves. Specially designed transcatheter mitral valve platforms are used in ongoing studies for native mitral valve regurgitation. We present our single centre experience with transcatheter mitral valve implantation-transapical approach procedures in eleven patients...
August 1, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28268011/hands-on-surgical-training-of-congenital-heart-surgery-using-3-dimensional-print-models
#6
Shi-Joon Yoo, Thomas Spray, Erle H Austin, Tae-Jin Yun, Glen S van Arsdell
OBJECTIVE: Patient-based congenital heart surgery (CHS) training is opportunity-based and difficult. Three-dimensional (3D) print models of the heart were used for hands-on surgical training (HOST) at the 2015 AATS and subsequently in 2 local institutions. We aim to introduce the process of 3D printing for surgical simulation and to present the attendee's responses. METHODS: Using CT or MR angiograms, the models of congenital heart disease were created and printed with flexible rubberlike material...
February 9, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28183437/cardiac-3d-printing-and-its-future-directions
#7
REVIEW
Marija Vukicevic, Bobak Mosadegh, James K Min, Stephen H Little
Three-dimensional (3D) printing is at the crossroads of printer and materials engineering, noninvasive diagnostic imaging, computer-aided design, and structural heart intervention. Cardiovascular applications of this technology development include the use of patient-specific 3D models for medical teaching, exploration of valve and vessel function, surgical and catheter-based procedural planning, and early work in designing and refining the latest innovations in percutaneous structural devices. In this review, we discuss the methods and materials being used for 3D printing today...
February 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28063755/-congenital-heart-disease-recent-technical-advances-in-three-dimensional-echocardiography
#8
Clement Karsenty, Khaled Hadeed, Philippe Acar
The recent technical advances allow the use in practice of three-dimensional echocardiography in children especially through the new high frequency matrix probe. It is difficult or even impossible to hold breathing during children' acquisition so to avoid motion full volume artifact, one beat and live 3D modes are suitable. 3D echocardiography is more accurate than 2D to assess the size, location, and relationship with surrounding structures of atrial and ventricular septal defects and thus helps in the therapeutic decision...
May 2017: La Presse Médicale
https://www.readbyqxmd.com/read/28038838/-interventional-cardiac-catheterization-in-congenital-heart-disease
#9
François Godart, Ali Houeijeh
Interventional cardiac catheterization has a major place in the management of congenital heart disease. Since the Rashkind atrioseptostomy in mid-1960s, many techniques have been developed. For some, it is necessary to close a cardiac or extracardiac shunt using occluder (double disc system, plug, coil…): closure of atrial septal defect, ventricular septal defect or patent arterial duct. For others, it is necessary to treat a valvular or vascular stenosis using a balloon catheter: dilatation of the pulmonary or the aortic valve, dilatation of aortic coarctation...
May 2017: La Presse Médicale
https://www.readbyqxmd.com/read/27990542/3d-templated-fully-automated-microfluidic-input-output-multiplexer-for-endocrine-tissue-culture-and-secretion-sampling
#10
Xiangpeng Li, Jessica C Brooks, Juan Hu, Katarena I Ford, Christopher J Easley
A fully automated, 16-channel microfluidic input/output multiplexer (μMUX) has been developed for interfacing to primary cells and to improve understanding of the dynamics of endocrine tissue function. The device utilizes pressure driven push-up valves for precise manipulation of nutrient input and hormone output dynamics, allowing time resolved interrogation of the cells. The ability to alternate any of the 16 channels from input to output, and vice versa, provides for high experimental flexibility without the need to alter microchannel designs...
January 17, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/27677879/preoperative-planning-with-three-dimensional-reconstruction-of-patient-s-anatomy-rapid-prototyping-and-simulation-for-endoscopic-mitral-valve-repair
#11
Peyman Sardari Nia, Samuel Heuts, Jean Daemen, Peter Luyten, Jindrich Vainer, Jan Hoorntje, Emile Cheriex, Jos Maessen
Objectives: Mitral valve repair performed by an experienced surgeon is superior to mitral valve replacement for degenerative mitral valve disease; however, many surgeons are still deterred from adapting this procedure because of a steep learning curve. Simulation-based training and planning could improve the surgical performance and reduce the learning curve. The aim of this study was to develop a patient-specific simulation for mitral valve repair and provide a proof of concept of personalized medicine in a patient prospectively planned for mitral valve surgery...
February 1, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/27324801/3d-printed-modeling-of-the-mitral-valve-for-catheter-based-structural-interventions
#12
Marija Vukicevic, Daniel S Puperi, K Jane Grande-Allen, Stephen H Little
As catheter-based structural heart interventions become increasingly complex, the ability to effectively model patient-specific valve geometry as well as the potential interaction of an implanted device within that geometry will become increasingly important. Our aim with this investigation was to combine the technologies of high-spatial resolution cardiac imaging, image processing software, and fused multi-material 3D printing, to demonstrate that patient-specific models of the mitral valve apparatus could be created to facilitate functional evaluation of novel trans-catheter mitral valve repair strategies...
February 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/27149367/cardiothoracic-applications-of-3-dimensional-printing
#13
REVIEW
Andreas A Giannopoulos, Michael L Steigner, Elizabeth George, Maria Barile, Andetta R Hunsaker, Frank J Rybicki, Dimitris Mitsouras
Medical 3-dimensional (3D) printing is emerging as a clinically relevant imaging tool in directing preoperative and intraoperative planning in many surgical specialties and will therefore likely lead to interdisciplinary collaboration between engineers, radiologists, and surgeons. Data from standard imaging modalities such as computed tomography, magnetic resonance imaging, echocardiography, and rotational angiography can be used to fabricate life-sized models of human anatomy and pathology, as well as patient-specific implants and surgical guides...
September 2016: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/27142402/clinical-application-and-multidisciplinary-assessment-of-three-dimensional-printing-in-double-outlet-right-ventricle-with-remote-ventricular-septal-defect
#14
Swati Garekar, Alpa Bharati, Manish Chokhandre, Shivaji Mali, Bhadra Trivedi, Vishal P Changela, Narayan Solanki, Sarang Gaikwad, Vijay Agarwal
BACKGROUND: Double outlet right ventricle (DORV) with two well-developed ventricles and with a remote ventricular septal defect (VSD) may present a therapeutic challenge. Echocardiographic imaging of such complex cases does not always provide all of the information required to decide on an operative approach (biventricular or univentricular) and to design an intracardiac baffle to direct left ventricular outflow through the VSD and to the aorta for biventricular repair. A three dimensional (3D) printed model of the heart based upon data derived from computed tomography (CT) or magnetic resonance imaging (MRI) may contribute to a more complete appreciation of the intracardiac anatomy...
May 2016: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/27106636/optimizing-photo-encapsulation-viability-of-heart-valve-cell-types-in-3d-printable-composite-hydrogels
#15
Laura Hockaday Kang, Patrick A Armstrong, Lauren Julia Lee, Bin Duan, Kevin Heeyong Kang, Jonathan Talbot Butcher
Photocrosslinking hydrogel technologies are attractive for the biofabrication of cardiovascular soft tissues, but 3D printing success is dependent on multiple variables. In this study we systematically test variables associated with photocrosslinking hydrogels (photoinitiator type, photoinitiator concentration, and light intensity) for their effects on encapsulated cells in an extrusion 3D printable mixture of methacrylated gelatin/poly-ethylene glycol diacrylate/alginate (MEGEL/PEGDA3350/alginate). The fabrication conditions that produced desired hydrogel mechanical properties were compared against those that optimize aortic valve or mesenchymal stem cell viability...
February 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/27066785/state-of-the-art-review-of-3d-bioprinting-for-cardiovascular-tissue-engineering
#16
REVIEW
Bin Duan
3D bioprinting is a group of rapidly growing techniques that allows building engineered tissue constructs with complex and hierarchical structures, mechanical and biological heterogeneity. It enables implementation of various bioinks through different printing mechanisms and precise deposition of cell and/or biomolecule laden biomaterials in predefined locations. This review briefly summarizes applicable bioink materials and various bioprinting techniques, and presents the recent advances in bioprinting of cardiovascular tissues, with focusing on vascularized constructs, myocardium and heart valve conduits...
January 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/26758411/calcium-distribution-patterns-of-the-aortic-valve-as-a-risk-factor-for-the-need-of-permanent-pacemaker-implantation-after-transcatheter-aortic-valve-implantation
#17
COMPARATIVE STUDY
Buntaro Fujita, Maximilian Kütting, Moritz Seiffert, Smita Scholtz, Sandrine Egron, Emir Prashovikj, Jochen Börgermann, Timm Schäfer, Werner Scholtz, Rainer Preuss, Jan Gummert, Ulrich Steinseifer, Stephan M Ensminger
AIMS: New-onset conduction disturbances still represent a considerable problem after transcatheter aortic valve implantation (TAVI). The aim of this study was to identify calcification patterns with an elevated risk for permanent pacemaker implantation (PPI) after TAVI and investigate underlying mechanisms in an ex vivo setting. METHODS AND RESULTS: One hundred and sixty-two patients who underwent TAVI with the Edwards SAPIEN XT(®) or Medtronic CoreValve(®) at our institution were analysed...
December 2016: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/26071991/three-dimensional-printing-for-in%C3%A2-vivo-visualization-of-his-bundle-pacing-leads
#18
Terry Bauch, Pugazhendhi Vijayaraman, Gopi Dandamudi, Kenneth Ellenbogen
Transvenous pacing leads have been implicated in tricuspid valve dysfunction, and our group has adopted routine use of His bundle pacing to mitigate this effect. Three-dimensional (3D) printing technology holds great promise for advancing medicine, but the high start-up costs can be a deterrent. Seeking confirmation of optimal lead placement relative to the tricuspid annulus, we used low-cost commercial and public domain technologies to generate 3D-printed hearts from selected patients with His bundle pacing leads...
August 1, 2015: American Journal of Cardiology
https://www.readbyqxmd.com/read/25847966/development-of-an-algorithm-to-plan-and-simulate-a-new-interventional-procedure
#19
Buntaro Fujita, Maximilian Kütting, Smita Scholtz, Marc Utzenrath, Kavous Hakim-Meibodi, Lech Paluszkiewicz, Christoph Schmitz, Jochen Börgermann, Jan Gummert, Ulrich Steinseifer, Stephan Ensminger
OBJECTIVES: The number of implanted biological valves for treatment of valvular heart disease is growing and a percentage of these patients will eventually undergo a transcatheter valve-in-valve (ViV) procedure. Some of these patients will represent challenging cases. The aim of this study was to develop a feasible algorithm to plan and in vitro simulate a new interventional procedure to improve patient outcome. METHODS: In addition to standard diagnostic routine, our algorithm includes 3D printing of the annulus, hydrodynamic measurements and high-speed analysis of leaflet kinematics after simulation of the procedure in different prosthesis positions as well as X-ray imaging of the most suitable valve position to create a 'blueprint' for the patient procedure...
July 2015: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/25775166/current-progress-in-3d-printing-for-cardiovascular-tissue-engineering
#20
REVIEW
Bobak Mosadegh, Guanglei Xiong, Simon Dunham, James K Min
3D printing is a technology that allows the fabrication of structures with arbitrary geometries and heterogeneous material properties. The application of this technology to biological structures that match the complexity of native tissue is of great interest to researchers. This mini-review highlights the current progress of 3D printing for fabricating artificial tissues of the cardiovascular system, specifically the myocardium, heart valves, and coronary arteries. In addition, how 3D printed sensors and actuators can play a role in tissue engineering is discussed...
June 2015: Biomedical Materials
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