Laurine Reese, Sven Thomas Niepmann, Philip Düsing, Lea Hänschke, Thomas Beiert, Sebastian Zimmer, Georg Nickenig, Reinhard Bauer, Felix Jansen, Andreas Zietzer
AIM: Inflammation and calcification are hallmarks in the development of aortic valve stenosis (AVS). Ceramides mediate inflammation and calcification in the vascular tissue. The highly abundant d18:1,16:0 ceramide (C16) has been linked to increased cardiovascular mortality and obesity. In this study, we investigate the role of ceramide synthase 5 (CerS5), a critical enzyme for C16 ceramide synthesis, in the development of AVS, particularly in conjunction with a high-fat/high-cholesterol diet (Western diet, WD)...
March 28, 2024: Acta Physiologica