Beiyu Tang, Xue Li, Thorsten Maretzky, Jose Manuel Perez-Aguilar, David McIlwain, Yifang Xie, Yufang Zheng, Tak W Mak, Harel Weinstein, Carl P Blobel
The metalloprotease ADAM17 (a disintegrin and metalloprotease 17) regulates EGF-receptor and TNFα signaling, thereby not only protecting the skin and intestinal barrier, but also contributing to autoimmunity. ADAM17 can be rapidly activated by many stimuli through its transmembrane domain (TMD), with the seven membrane-spanning inactive Rhomboids (iRhom) 1 and 2 implicated as candidate regulatory partners. However, several alternative models of ADAM17 regulation exist that do not involve the iRhoms, such as regulation through disulfide bond exchange or through interaction with charged phospholipids...
February 26, 2020: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology