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Exchangeable heart valve

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https://www.readbyqxmd.com/read/27770000/left-and-right-ventricular-hemodynamic-forces-in-healthy-volunteers-and-elite-athletes-assessed-with-4d-flow-magnetic-resonance-imaging
#1
Per Martin Arvidsson, Johannes Töger, Marcus Carlsson, Katarina Steding-Ehrenborg, Gianni Pedrizzetti, Einar Heiberg, Hakan Arheden
Intracardiac blood flow is driven by hemodynamic forces that are exchanged between the blood and myocardium. Previous studies have been limited to 2D measurements or investigated only LV forces. Right ventricular forces and their mechanistic contribution to asymmetric redirection of flow in the RV have not been measured. We therefore aimed to quantify three-dimensional hemodynamic forces in both ventricles in a cohort of healthy subjects, using magnetic resonance imaging 4D flow measurements. 25 controls,14 elite endurance athletes, and two patients with left ventricular dyssynchrony were included...
October 21, 2016: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/27720494/assessment-of-changes-in-hemodynamics-and-intrathoracic-fluid-using-electrical-cardiometry-during-autologous-blood-harvest
#2
Jitin Narula, Usha Kiran, Poonam Malhotra Kapoor, Minati Choudhury, Palleti Rajashekar, Ujjwal Kumar Chowdhary
OBJECTIVE: To evaluate the effect of autologous blood harvest (ABH)-induced volume shifts using electrical cardiometry (EC) in patients with pulmonary artery hypertension secondary to left heart disease. DESIGN: Prospective, randomized, controlled trial. SETTING: A tertiary care hospital. PARTICIPANTS: The study comprised 50 patients scheduled to undergo heart valve replacement. INTERVENTIONS: Patients were divided randomly into 2 experimental groups that were distinguished by whether ABH was performed...
July 26, 2016: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/27306448/factor-v-and-viii-deficiency-treated-with-therapeutic-plasma-exchange-prior-to-redo-mitral-valve-replacement
#3
Laura Brown, Lowell Tilzer, Fred Plapp
A 33-year-old male was admitted to the hospital for a repeat mitral valve replacement. The original surgery, performed in India in 2008 due to rheumatic heart disease, required massive amounts of plasma replacement during and after the surgery. The patient was admitted to our hospital with extremely low Factor V and Factor VIII activities due to a rare combined Factor V and Factor VIII deficiency. His clinical condition on admission was grave due to severe pulmonary hypertension. It was decided to replace the patient's Factor V using therapeutic plasma exchange (TPE) with fresh frozen plasma (FFP) just prior to surgery, and his Factor VIII with Factor VIII concentrate...
June 16, 2016: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/26989287/intracardiac-thrombosis-in-sickle-cell-disease
#4
Marzieh Nikparvar, Mohammad Reza Evazi, Tasnim Eftekhari, Farzaneh Moosavi
In patients with sickle cell disease, thrombotic microangiopathy is a rare complication. Also in sickle cell disease, intracardiac thrombus formation without structural heart diseases or atrial arrhythmias is a rare phenomenon. We herein describe a 22-year-old woman, who was a known case of sickle cell-βthalassemia, had a history of recent missed abortion, and was admitted with a vaso-occlusive crisis. The patient had manifestations of microangiopathic hemolytic anemia, including laboratory evidence of hemolytic anemia, thrombocytopenia, respiratory distress, fever, jaundice, and abnormal liver function and coagulation tests, accompanied by clot formation on the Eustachian valve of the inferior vena cava in the right atrium and also a long and worm-like thrombus in the right ventricle...
March 2016: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/26979006/sutureless-aortic-valve-early-and-mid-term-results-at-a-single-center
#5
Amjad Shalabi, Ehud Raanani, Amihai Shinfeld, Rafael Kuperstein, Alexander Kogan, Alexander Lipey, Eyal Nachum, Dan Spiegelstein
UNLABELLED: Background: Prolonged life expectancy has increased the number of elderly high risk patients referred for surgical aortic valve replacement (AVR). These referred high risk patients may benefit from sutureless bioprosthesis procedures which reduce mortality and morbidity. OBJECTIVES: To present our initial experience with sutureless aortic bioprotheses, including clinical and echocardiographic results, in elderly high risk patients referred for AVR. METHODS: Forty patients (15 males, mean age 78 ± 7 years) with symptomatic severe aortic stenosis underwent AVR with the 3F Enable or Perceval sutureless bioprosthesis during the period December 2012 to May 2014...
February 2016: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/26929197/design-considerations-and-challenges-for-mechanical-stretch-bioreactors-in-tissue-engineering
#6
Ying Lei, Zannatul Ferdous
With the increase in average life expectancy and growing aging population, lack of functional grafts for replacement surgeries has become a severe problem. Engineered tissues are a promising alternative to this problem because they can mimic the physiological function of the native tissues and be cultured on demand. Cyclic stretch is important for developing many engineered tissues such as hearts, heart valves, muscles, and bones. Thus a variety of stretch bioreactors and corresponding scaffolds have been designed and tested to study the underlying mechanism of tissue formation and to optimize the mechanical conditions applied to the engineered tissues...
May 2016: Biotechnology Progress
https://www.readbyqxmd.com/read/26905181/paediatric-mechanical-circulatory-support-with-berlin-heart-excor-development-and-outcome-of-a-23-year-experience
#7
REVIEW
Roland Hetzer, Friedrich Kaufmann, Eva Maria Delmo Walter
This paper reviews the development and establishment of the Berlin Heart EXCOR® (BHE®) as a paediatric mechanical circulatory support and reports our entire experience with regard to indications, timing of implantation and explantation and outcome. The Berlin group reported the first successful paediatric bridge to transplantation using a pulsatile pneumatic paracorporeal biventricular assist device, the BHE®, in 1990 in an 8-year-old boy with end-stage heart failure and coarctation of the aorta. This experience prompted them to develop miniaturized pump systems for children through the company Berlin Heart Mediproduct GmbH...
August 2016: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/26434082/case-report-prothesis-patient-mismatch-after-aortic-valve-replacement
#8
REVIEW
Luis Rodriguez-Ospina, Juan Garcia-Morell, Carla P Rodriguez-Monserrate, Julio Valentin-Nieves
Valve replacement is the standard surgical treatment of diseased valves that cannot be repaired. The main goal of replacement is to exchange the diseased valve with one that has the engineering and hemodynamics as close as possible to the disease free native valve. However due to mechanical and fluid dynamic constraints all prosthetic heart valves (PHVs) are smaller than normal and thus are inherently stenotic. This represents a challenge when it comes time to replace a valve. The correct valve with the correct and matching profile has to be selected before the procedure to avoid possible complications...
April 2015: Boletín de la Asociación Médica de Puerto Rico
https://www.readbyqxmd.com/read/26314348/-intensive%C3%A2-care-treatment-of-patients-with-left-ventricular-assist-devices
#9
B Steinlechner, Daniel Zimpfer, Arno Schiferer, Nikolaus Heinrich, Thomas Schlöglhofer, Angela Rajek, Martin Dworschak, Michael Hiesmayr
Apart from heart transplantation, implantation of a left ventricular assist device (LVAD) is the only established surgical treatment for therapy-refractory terminal left heart failure, The specific intensive care unit (ICU) management of these patients depends on the reason for the ICU admission and requires understanding of the characteristic hemodynamics of non-pulsatile LVADs as well as of the inherent problems. Knowledge about the specific features in hemodynamic monitoring, understanding of pump characteristics, management of anticoagulation and hemostasis and the handling of problems, such as right heart failure, aortic valve insufficiency and infections is essential...
September 2015: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/26139741/heart-valve-surgery-in-patients-with-homozygous-sickle-cell-disease-a-management-strategy
#10
El Mehdi Moutaouekkil, Abdelmalek Najib, Rida Ajaja, Moha Arji, Anas Slaoui
BACKGROUND: Patients with the homozygous sickle cell disease have increased perioperative mortality. Some indications like heart valve surgery, may justify an exchange blood transfusion to reduce the proportion of hemoglobin S (HbS) and complications. SUBJECTS AND METHODS: We report two female cases aged 20 and 27, of African origin with homozygous sickle cell anemia who underwent heart valve surgery to treat mitral valve regurgitation. This presentation describes the perioperative considerations including anesthesia and postoperative care...
July 2015: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/25972923/bacterial-contamination-of-suction-catheter-tips-during-aortic-valve-replacement-surgery-a-prospective-observational-cohort-study
#11
Johanna Larsson, Sofia Sutherland, Åsa Söderström, Christine Roman-Emanuel, Anders Jeppsson, Elisabeth Hansson Olofsson, Per-Arne Svensson
BACKGROUND: Bacterial mediastinitis is a severe complication after open heart surgery. The infection causes prolonged hospitalization and an increased mortality risk. Observations from orthopaedic surgery showed that the suction catheter used during surgery is commonly contaminated with bacteria. The aim of this study was to describe the prevalence of suction catheter contamination in cardiac surgery and to study if suction time influences the contamination risk. METHODS: Fifty suction catheter tips were collected during 25 aortic valve replacement operations...
2015: Patient Safety in Surgery
https://www.readbyqxmd.com/read/25234760/a-hybrid-mock-circulation-loop-for-a-total-artificial-heart
#12
Frank Nestler, Andrew P Bradley, Stephen J Wilson, Daniel L Timms, O Howard Frazier, William E Cohn
Rotary blood pumps are emerging as a viable technology for total artificial hearts, and the development of physiological control algorithms is accelerated with new evaluation environments. In this article, we present a novel hybrid mock circulation loop (HMCL) designed specifically for evaluation of rotary total artificial hearts (rTAH). The rTAH is operated in the physical domain while all vasculature elements are embedded in the numerical domain, thus combining the strengths of both approaches: fast and easy exchange of the vasculature model together with improved controllability of the pump...
September 2014: Artificial Organs
https://www.readbyqxmd.com/read/25018774/a-new-kind-of-auxiliary-heart-in-insects-functional-morphology-and-neuronal-control-of-the-accessory-pulsatile-organs-of-the-cricket-ovipositor
#13
Reinhold Hustert, Matthias Frisch, Alexander Böhm, Günther Pass
INTRODUCTION: In insects, the pumping of the dorsal heart causes circulation of hemolymph throughout the central body cavity, but not within the interior of long body appendages. Hemolymph exchange in these dead-end structures is accomplished by special flow-guiding structures and/or autonomous pulsatile organs ("auxiliary hearts"). In this paper accessory pulsatile organs for an insect ovipositor are described for the first time. We studied these organs in females of the cricket Acheta domesticus by analyzing their functional morphology, neuroanatomy and physiological control...
2014: Frontiers in Zoology
https://www.readbyqxmd.com/read/24471156/fully-automated-on-line-two-dimensional-liquid-chromatography-in-combination-with-esi-ms-ms-detection-for-quantification-of-sugar-phosphates-in-yeast-cell-extracts
#14
Kristaps Klavins, Dinh Binh Chu, Stephan Hann, Gunda Koellensperger
A mass spectrometric quantitative assay was developed for the analysis of 10 sugar phosphates in the yeast Pichia pastoris. As a novelty, two-dimensional chromatography based on a fully automated heart-cutting LC-LC technique was introduced. Using a ten-port valve, ten fractions of the first chromatographic dimension, i.e. anion exchange chromatography (AEC), were transferred and separated by the orthogonal second dimension, i.e. separation on porous graphitized carbon. The chromatographic separation on the second dimension was optimized for each transferred fraction minimizing the separation time and ensuring complete removal of the salt constituents of the AEC eluents...
March 21, 2014: Analyst
https://www.readbyqxmd.com/read/24436373/periodic-heartbeat-reversals-cause-cardiogenic-inspiration-and-expiration-with-coupled-spiracle-leakage-in-resting-blowflies-calliphora-vicina
#15
Lutz T Wasserthal
Respiration in insects is thought to be independent of the circulatory system because insects typically lack respiratory pigments and because oxygen transport occurs in the gaseous phase through a ramified tracheal system by diffusion and convection directly to the tissues. In the blowfly, as in other insects with periodic heartbeat reversal, the haemolymph is periodically shifted between the anterior body and abdomen, exerting alternating pressure changes on the compliant tracheae in the thorax and in the abdomen...
May 1, 2014: Journal of Experimental Biology
https://www.readbyqxmd.com/read/24418111/variants-in-the-notch1-gene-in-patients-with-aortic-coarctation
#16
Olga Freylikhman, Tatyana Tatarinova, Natalia Smolina, Sergey Zhuk, Alexandra Klyushina, Artem Kiselev, Olga Moiseeva, Gunnar Sjoberg, Anna Malashicheva, Anna Kostareva
BACKGROUND AND OBJECTIVE: Malformations of the left ventricular outflow tract are one of the most common forms of congenital heart disorders. Recently, it has been shown that mutations in the NOTCH1 gene can lead to bicuspid aortic valve, aortic aneurysm, and hypoplastic left heart syndrome. The aim of our study was to estimate the frequency of NOTCH1 gene mutations/substitutions in patients with aortic coarctation, isolated or combined with bicuspid aortic valve. DESIGN AND PATIENTS: The study included 51 children with coarctation...
September 2014: Congenital Heart Disease
https://www.readbyqxmd.com/read/24321313/protein-stability-in-stored-decellularized-heart-valve-scaffolds-and-diffusion-kinetics-of-protective-molecules
#17
Shangping Wang, Harriëtte Oldenhof, Xiaolei Dai, Axel Haverich, Andres Hilfiker, Michael Harder, Willem F Wolkers
Decellularized tissues can be used as matrix implants. The aims of this study were to investigate protein stability and solvent accessibility in decellularized pulmonary heart valve tissues. Protein denaturation profiles of tissues were studied by differential scanning calorimetry. Protein solvent accessibility of tissue exposed to D2O, and diffusion kinetics of various protective molecules were studied by Fourier transform infrared spectroscopy. Little changes were observed in the protein denaturation temperature during storage, at either 5 or 40°C...
February 2014: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/23912910/quantification-of-cardiomyocyte-hypertrophy-by-cardiac-magnetic-resonance-implications-for-early-cardiac-remodeling
#18
Otavio R Coelho-Filho, Ravi V Shah, Richard Mitchell, Tomas G Neilan, Heitor Moreno, Bridget Simonson, Raymond Kwong, Anthony Rosenzweig, Saumya Das, Michael Jerosch-Herold
BACKGROUND: Cardiomyocyte hypertrophy is a critical precursor to the development of heart failure. Methods to phenotype cellular hypertrophy noninvasively are limited. The goal was to validate a cardiac magnetic resonance-based approach for the combined assessment of extracellular matrix expansion and cardiomyocyte hypertrophy. METHODS AND RESULTS: Two murine models of hypertension (n=18, with n=15 controls) induced by l-N(G)-nitroarginine methyl ester (L-NAME) and pressure overload (n=11) from transaortic constriction (TAC) were imaged by cardiac magnetic resonance at baseline and 7 weeks after L-NAME treatment or up to 7 weeks after TAC...
September 10, 2013: Circulation
https://www.readbyqxmd.com/read/23748885/characterization-of-mercury-containing-protein-in-human-plasma
#19
Zhaojun Yun, Lu Li, Lihong Liu, Bin He, Xingchen Zhao, Guibin Jiang
Characterization of mercury binding protein in the human body is very important for understanding the metabolism and the mechanism of toxication of ingested mercuric compounds. In this study, mercury-containing protein in human plasma was separated by on-line heart-cutting two-dimensional high performance liquid chromatography (2D-HPLC). This 2D separation system used size exclusion liquid chromatography (SEC) followed by weak anion exchange liquid chromatography (WAX) and the two LC parts were coupled by a six-port valve equipped with a storage loop and controled by the computer...
June 27, 2013: Metallomics: Integrated Biometal Science
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