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Heart valve replacement in the young

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https://www.readbyqxmd.com/read/27895692/impact-of-postoperative-duration-of-aspirin-use-on-longevity-of-bioprosthetic-pulmonary-valve-in-patients-who-underwent-congenital-heart-disease-repair
#1
Tae-Woong Hwang, Sung-Ook Kim, Sang-Yun Lee, Seong-Ho Kim, Eun-Young Choi, So-Ick Jang, Su-Jin Park, Hye-Won Kwon, Hyo-Bin Lim, Chang-Ha Lee, Eun-Seok Choi
PURPOSE: Generally, aspirin is used as a protective agent against thrombogenic phenomenon after pulmonary valve replacement (PVR) using a bioprosthetic valve. However, the appropriate duration of aspirin use is unclear. We analyzed the impact of postoperative duration of aspirin use on the longevity of bioprosthetic pulmonary valves in patients who underwent repair for congenital heart diseases. METHODS: We retrospectively reviewed the clinical data of 137 patients who underwent PVR using a bioprosthetic valve between January 2000 and December 2003...
November 2016: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/27855225/incidence-predictors-and-clinical-outcomes-of-postoperative-cardiac-tamponade-in-patients-undergoing-heart-valve-surgery
#2
Seng Chan You, Chi Young Shim, Geu-Ru Hong, Darae Kim, In Jeong Cho, Sak Lee, Hyuck-Jae Chang, Jong-Won Ha, Byung-Chul Chang, Namsik Chung
This study aimed to investigate the incidence, predictors, and clinical outcomes of cardiac tamponade after heart valve surgery. A total of 556 patients who underwent heart valve surgery in a single tertiary center between January 2010 and March 2012 were studied. All patients underwent transthoracic echocardiography (TTE) about 5 days after surgery and TTE was repeated regularly. Patients with suspected acute pericardial hemorrhage were excluded. Cardiac tamponade occurred in twenty-four (4.3%) patients and all underwent surgical or percutaneous pericardial drainage...
2016: PloS One
https://www.readbyqxmd.com/read/27756541/growth-and-maturation-of-heart-valves-leads-to-changes-in-endothelial-cell-distribution-impaired-function-decreased-metabolism-and-reduced-cell-proliferation
#3
Lindsey J Anstine, Chris Bobba, Samir Ghadiali, Joy Lincoln
Risk factors of heart valve disease are well defined and prolonged exposure throughout life leads to degeneration and dysfunction in up to 33% of the population. While aortic valve replacement remains the most common need for cardiovascular surgery particularly in those aged over 65, the underlying mechanisms of progressive deterioration are unknown. In other cardiovascular systems, a decline in endothelial cell integrity and function play a major role in promoting pathological changes, and while similar mechanisms have been speculated in the valves, studies to support this are lacking...
October 15, 2016: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/27696730/the-future-of-heart-valve-replacement-recent-developments-and-translational-challenges-for-heart-valve-tissue-engineering
#4
Emanuela S Fioretta, Petra E Dijkman, Maximilian Y Emmert, Simon P Hoerstrup
Heart valve replacement is often the only solution for patients suffering from valvular heart disease. However, currently available valve replacements require either life-long anti-coagulation or are associated with valve degeneration and calcification. Moreover, they are suboptimal for young patients, because they do not adapt to the somatic growth. Tissue-engineering has been proposed as a promising approach to fulfill the urgent need for heart valve replacements with regenerative and growth capacity. This review will start with an overview on the currently available valve substitutes and the techniques for heart valve replacement...
September 30, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27621906/transcatheter-aortic-valve-implantation-in-a-young-heart-transplant-recipient-crossing-the-traditional-boundaries
#5
Khalil Ahmad, Christian Juhl Terkelsen, Kim Allan Terp, Ole Norling Mathiassen, Bjarne Linde Nørgaard, Henning Rud Andersen, Steen Hvitfeldt Poulsen
Transcatheter aortic valve implantation (TAVI) is an established therapeutic alternative to surgical aortic valve replacement (SAVR) in high-risk or inoperable patients with symptomatic aortic valve stenosis. Hitherto, TAVI is not recommended in young and low-intermediate risk patients. However, TAVI may also serve as an alternative to SAVR in selected young patients, e.g., patients who have previously undergone multiple cardiac surgery procedures. We report a case of trans-femoral TAVI in a 25-year-old heart transplant (HTx) recipient with prior surgery for congenital heart disease...
August 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27610249/severe-bioprosthetic-mitral-valve-stenosis-and-heart-failure-in-a-young-woman-with-systemic-lupus-erythematosus
#6
Siddharth Wartak, Isaac Akkad, Adnan Sadiq, Gregory Crooke, Manfred Moskovits, Robert Frankel, Gerald Hollander, Jacob Shani
A 23-year-old African American woman with a past medical history of systemic lupus erythematous (SLE), secondary hypertension, and end stage renal disease (ESRD) on hemodialysis for eight years was stable until she developed symptomatic severe mitral regurgitation with preserved ejection fraction. She underwent a bioprosthetic mitral valve replacement (MVR) at outside hospital. However, within a year of her surgery, she presented to our hospital with NYHA class IV symptoms. She was treated for heart failure but in view of her persistent symptoms and low EF was considered for heart and kidney transplant...
2016: Case Reports in Cardiology
https://www.readbyqxmd.com/read/27570204/planar-biaxial-testing-of-heart-valve-cusp-replacement-biomaterials-experiments-theory-and-material-constants
#7
Michel R Labrosse, Reza Jafar, Janet Ngu, Munir Boodhwani
OBJECTIVES: Aortic valve (AV) repair has become an attractive option to correct aortic insufficiency. Yet, cusp reconstruction with various cusp replacement materials has been associated with greater long-term repair failures, and it is still unknown how such materials mechanically compare with native leaflets. We used planar biaxial testing to characterize six clinically relevant cusp replacement materials, along with native porcine AV leaflets, to ascertain which materials would be best suited for valve repair...
November 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27547146/transcatheter-aortic-valve-in-valve-replacement-instead-of-a-4th-sternotomy-in-a-21-year-old-woman-with-aortic-homograft-failure
#8
José G Díez, Michael Schechter, Kathryn G Dougherty, Ourania Preventza, Joseph S Coselli
Transcatheter aortic valve replacement (TAVR) is a well-established method for replacing native aortic valves; however, it was conceived for elderly patients with aortic valve stenosis, and the lack of data on long-term durability has led practitioners to restrict the use of TAVR to patients who have short life expectancies. Here, we describe the case of a 21-year-old woman who had undergone 3 previous open aortic valve replacements and who presented with symptoms of recurrent valvular failure. Transthoracic echocardiograms and computed tomographic angiograms revealed a degenerating aortic root homograft with substantial calcification, moderate-to-severe aortic valve stenosis, and severe aortic valve regurgitation...
August 2016: Texas Heart Institute Journal
https://www.readbyqxmd.com/read/27530875/fortune-or-misfortune-asymptomatic-delayed-presentation-of-complete-dehiscence-of-mechanical-aortic-valve-conduit-and-pseudoaneurysm
#9
Kyung Taek Oh, Joseph Derose, Cynthia Taub
Complete dehiscence of a composite aortic valve graft with pseudoaneurysm formation is a rare complication following aortic root replacement. This complication often takes place in the setting of acute graft infection and accompanies symptoms of heart failure, valve insufficiency or sepsis. We present a delayed, asymptomatic presentation of this complication in a young man with distant history of aortic root replacement and medically treated prosthetic valve endocarditis a year postoperatively. He had been non-adherent to warfarin over 10 years, but otherwise maintained a healthy life...
2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27530825/national-trends-in-hospitalizations-of-adults-with-tetralogy-of-fallot
#10
Ada C Stefanescu Schmidt, Doreen DeFaria Yeh, Sara Tabtabai, Kevin F Kennedy, Robert W Yeh, Ami B Bhatt
The population of adults with tetralogy of Fallot (TOF) is growing, and it is not known how the changes in age distribution, treatment strategies, and prevalence of co-morbidities impact their interaction with the health care system. We sought to analyze the frequency and reasons for hospital admissions over the past decade. We extracted serial cross-sectional data from the United States Nationwide Inpatient Sample on hospitalizations including the diagnostic code for TOF from 2000 to 2011. From 2000 to 2011, there were 20,545 admissions for subjects with TOF, with a steady increase in annual number...
September 15, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27476223/cardiac-surgery-for-valvular-heart-disease-at-a-referral-hospital-in-ethiopia-a-review-of-cases-operated-in-the-last-30-years
#11
Senbeta Guteta, Dejuma Yadeta, Aklilu Azazh, Dufera Mekonnen
BACKGROUND: Valvular heart disease has been a significant cause of heart disease worldwide. In Ethiopia, it particularly affects young individuals and constitutes the major cause of cardiovascular disease. Factors associated with choice of treatment for advanced valvular heart disease are variable. The objective of this study is to review surgery done for Ethiopian patients with valvular heart disease. METHODS: We analyzed data on patients who had valve surgery and follow-up at the Tikur Anbessa Specialized Hospital cardiology unit...
April 2016: Ethiopian Medical Journal
https://www.readbyqxmd.com/read/27440307/association-of-thoracic-aorta-calcium-score-with-left-ventricular-hypertrophy-and-clinical-outcomes-in-patients-with-severe-aortic-stenosis-after-aortic-valve-replacement
#12
In-Jeong Cho, Hyuk-Jae Chang, Ran Heo, In-Cheol Kim, Ji Min Sung, Byung-Chul Chang, Chi Young Shim, Geu-Ru Hong, Namsik Chung
BACKGROUND: Substantial aortic calcification is known to be associated with aortic stiffening and subsequent left ventricular (LV) hypertrophy. This study examined whether the thoracic aorta calcium score (TACS) is related to LV hypertrophy and whether it leads to an adverse prognosis in patients with severe aortic stenosis (AS) after aortic valve replacement (AVR). METHODS: We retrospectively reviewed 47 patients (mean age, 64 ± 11 years) with isolated severe AS who underwent noncontrast computed tomography of the entire thoracic aorta and who received AVR...
July 17, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27418982/left-main-percutaneous-coronary-intervention-and-transcatheter-aortic-valve-replacement-in-a-young-male-with-rheumatic-heart-disease-and-porcelain-aorta
#13
Vinod Chainani, Osman Perez, Ram Hanno, Patrick Hourani, Pablo Rengifo-Moreno, Pedro Martinez-Clark, Carlos E Alfonso
We highlight the presence of a calcified mass in the left main coronary artery without significant atherosclerosis seen in the other coronary arteries or in the peripheral large arteries. In our view, the calcified character of the obstruction and the calcification of the aortic valve are characteristic of a variant type of coronary artery disease (CAD) not associated with the same risk factors as diffuse coronary atherosclerosis, but, in this case, with rheumatic heart disease. This case report also emphasizes the interventional approach for patients with aortic valve stenosis secondary to rheumatic heart disease...
2016: Case Reports in Cardiology
https://www.readbyqxmd.com/read/27343522/aortic-and-mitral-valve-involvement-in-maroteaux-lamy-syndrome-vi-surgical-implications-in-the-enzyme-replacement-therapy-era
#14
Salvatore Torre, Mauro Scarpelli, Alessandro Salviati, Ebba Buffone, Giuseppe Faggian, Giovanni Battista Luciani
Open-heart operations in patients with mucopolysaccharidoses are exceedingly rare and pose distinct clinical challenges. Few reports exist of valve replacement in type VI mucopolysaccharidosis, mostly entailing combined mitral and aortic valve replacement. Here reported is the case of a young woman with mitral and aortic valve disease, in whom the surgical procedure was confined to the aortic valve. The rationale behind this strategy, particularly in light of the benefits offered by specific enzyme replacement therapy of type VI mucopolysaccharidosis, is discussed...
July 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27326237/choice-of-prosthetic-heart-valve-in-a-developing-country
#15
Shiv Kumar Choudhary, Sachin Talwar, Balram Airan
Mechanical prostheses and stented xenografts (bioprosthesis) are most commonly used substitutes for aortic and mitral valve replacement. The mechanical valves have the advantage of durability but are accompanied with the risk of thromboembolism, problems of long-term anticoagulation, and associated risk of bleeding. In contrast, bioprosthetic valves do not require long-term anticoagulation, but carry the risk of structural valve degeneration and re-operation. A mechanical valve is favoured in young patients (<40 years) if reliable anticoagulation is ensured...
2016: Heart Asia
https://www.readbyqxmd.com/read/27151607/clinical-outcomes-following-transcatheter%C3%A2-aortic-valve-replacement%C3%A2-in%C3%A2-asian-population
#16
Sung-Han Yoon, Jung-Min Ahn, Kentaro Hayashida, Yusuke Watanabe, Shinichi Shirai, Hsien-Li Kao, Wei-Hsian Yin, Michael Kang-Yin Lee, Edgar Tay, Motoharu Araki, Futoshi Yamanaka, Takahide Arai, Mao-Shin Lin, Jun-Bean Park, Duk-Woo Park, Soo-Jin Kang, Seung-Whan Lee, Young-Hak Kim, Cheol Whan Lee, Seong-Wook Park, Toshiya Muramatsu, Michiya Hanyu, Ken Kozuma, Hyo-Soo Kim, Shigeru Saito, Seung-Jung Park
OBJECTIVES: This study describes the characteristics of a real-world Asian patient population treated with transcatheter aortic valve replacement (TAVR) and evaluates their clinical outcomes. BACKGROUND: No previously reported randomized or observational studies adequately assess the safety and efficacy of TAVR in an Asian population. METHODS: The Asian TAVR registry is an international multicenter study that enrolled patients with aortic stenosis who underwent TAVR in Asian countries...
May 9, 2016: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/27142399/mitral-valve-surgery-for-rheumatic-lesions-in-young-patients
#17
B Cardoso, P Loureiro, I Gomes, A Gordo, N Banazol, I Fragata, C Trigo, F Pinto, José Fragata
BACKGROUND: The appropriateness of rheumatic mitral valve repair remains controversial due to the risks of recurrent mitral dysfunction and need for reoperation. The aims of this study were to determine the overall short- and long-term outcomes of pediatric rheumatic mitral valve surgery in our center. METHODS: Single-center, observational, retrospective study that analyzed the results of rheumatic mitral valve surgery in young patients, consecutively operated by the same team, between 1999 and 2014...
May 2016: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/27075154/-corrected-transposition-of-the-great-arteries-ventricular-septal-defect-tricuspid-regurgitation-and-pulmonary-hypertension-operated-at-middle-age-report-of-a-case
#18
Hideyuki Okawa, Takuya Kimura, Satoshi Yuhara, Jun Yokote, Yukifusa Yokoyama, Shuji Tamaki, Takaya Ota, Eiki Nishihara, Kenji Kuraishi
A 45-year-old male with corrected transposition of great arteries and the ventricular septal defect (VSD) was considered to have no indication for the total repair because of severe pulmonary hypertension in his young age. He was suffered from heart failure with absence at the age of 44. Detail examinations revealed the severe tricuspid valve regurgitation with VSD. We reevaluated him for the operative indication by the aspect of pulmonary hypertension. His pulmonary vascular resistance decreased with the administration of 100% oxygen, and no pulmonary vascular obstructions were detected in the lung specimen...
February 2016: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/27001674/outcomes-of-fontan-conversion-for-failing-fontan-circulation-mid-term-results
#19
Han Ki Park, Hong Ju Shin, Young Hwan Park
OBJECTIVES: We investigated the results of a revision of a previous Fontan connection to total cavopulmonary connection (TCPC) in patients with failing Fontan circulation. METHODS: From July 1998 to April 2013, 21 patients who had failing Fontan circulation underwent revision of the previous Fontan operation to TCPC. The median age at TCPC conversion was 17.9 years (range, 4.6-38.1 years) and the median interval between initial Fontan operation and TCPC was 13.8 years (range, 2...
July 2016: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/26988837/the-valvafric-study-a-registry-of-rheumatic-heart-disease-in-western-and-central-africa
#20
Samuel Kingué, Serigne Abdou Ba, Dhadi Balde, Mamadou Bocary Diarra, Jean-Baptiste Anzouan-Kacou, Benedict Anisubia, Jean-Marie Damorou, Pierre Ndobo, Alain Menanga, Abdoul Kane, Maurice Kakou-Guikahué, Monique Kenfack, Bernard Metogo, David Chelo, Euloge Yangnigni, Cabral Tantchou, Edmond Bertrand, Jean-Jacques Monsuez
BACKGROUND: There are few African data available on rheumatic heart disease (RHD). AIM: To provide data on the clinical characteristics and treatment of patients with RHD hospitalized in sub-Saharan Africa. METHODS: The VALVAFRIC study is a multicentre hospital-based retrospective registry of patients with RHD hospitalized in African cardiology departments from 2004 to 2008. RESULTS: Among 3441 patients with at least one mild RHD lesion seen on echocardiography in 5 years in 12 cardiology departments from seven countries, 1385 had severe lesions (502 men; 803 women; mean age 29...
May 2016: Archives of Cardiovascular Diseases
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