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https://www.readbyqxmd.com/read/29452440/operative-time-and-flap-failure-in-unilateral-and-bilateral-free-flap-breast-reconstruction
#1
Alvin C Kwok, Kyle Edwards, Daniel P Donato, Eric Tatro, Yizhe Xu, Angela P Presson, Jayant P Agarwal
BACKGROUND: There is an increasing trend toward bilateral breast reconstruction. Using the National Surgical Quality Improvement Program (NSQIP) database, we sought to understand the association between unilateral and bilateral free flap breast reconstruction and operative time and flap failure. METHODS: We selected a cohort of patients undergoing free flap breast reconstruction using the 2005 to 2010 NSQIP database. Cases were divided into unilateral and bilateral reconstruction...
February 16, 2018: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/29451641/splenic-implant-preservation-after-conservation-in-lactated-ringer%C3%A2-s-solution
#2
Argos Soares DE Matos Filho, Andy Petroianu, Valbert Nascimento Cardoso, Paula Vieira Teixeira Vidigal
OBJECTIVE: to evaluate the morphology and function of autogenous splenic tissue implanted in the greater omentum, 24 hours after storage in Ringer-lactate solution. METHODS: we divided 35 male rats into seven groups (n=5): Group 1: no splenectomy; Group 2: total splenectomy without implant; Group 3: total splenectomy and immediate autogenous implant; Group 4: total splenectomy, preservation of the spleen in Ringer-lactate at room temperature, then sliced ​​and implanted; Group 5: total splenectomy, ​​spleen sliced and preserved in Ringer-lactate at room temperature before implantation; Group 6: total splenectomy with preservation of the spleen in Ringer-lactate at 4°C and then sliced ​​and implanted; Group 7: total splenectomy and the spleen sliced for preservation in Ringer-lactate at 4°C before implantation...
2018: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/29451570/insights-into-the-formation-mechanism-of-two-dimensional-lead-halide-nanostructures
#3
Eugen Klein, Rostyslav Lesyuk, Christian Klinke
We present a colloidal synthesis strategy for lead halide nanosheets with a thickness of far below 100 nm. Due to the layered structure and the synthesis parameters the crystals of PbI 2 are initially composed of many polytypes. We propose a mechanism which gives insight into the chemical process of the PbI 2 formation. Further, we found that the crystal structure changes with increasing reaction temperature or by performing the synthesis for longer time periods changing for the final 2H structure. In addition, we demonstrate a route to prepare nanosheets of lead bromide as well as lead chloride in a similar way...
February 16, 2018: Nanoscale
https://www.readbyqxmd.com/read/29451142/cost-analysis-of-cervical-cancer-patients-with-different-medical-payment-modes-based-on-gamma-model-within-a-grade-a-tertiary-hospital
#4
Suo-Wei Wu, Tong Chen, Qi Pan, Liang-Yu Wei, Qin Wang, Jing-Chen Song, Chao Li, Ji Luo
Background: Cervical cancer shows a growing incidence and medical cost in recent years that has increased severe financial pressure on patients and medical insurance institutions. This study aimed to investigate the medical economic characteristics of cervical cancer patients with different payment modes within a Grade A tertiary hospital to provide evidence and suggestions for inpatient cost control and to verify the application of Gamma model in medical cost analysis. Methods: The basic and cost information of cervical cancer cases within a Grade A tertiary hospital in the year 2011-2016 were collected...
February 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29451088/a-marginalized-two-part-model-with-heterogeneous-variance-for-semicontinuous-data
#5
Valerie A Smith, John S Preisser
Semicontinuous data, characterized by a point mass at zero followed by a positive, continuous distribution, arise frequently in medical research. These data are typically analyzed using two-part mixtures that separately model the probability of incurring a positive outcome and the distribution of positive values among those who incur them. In such a conditional specification, however, standard two-part models do not provide a marginal interpretation of covariate effects on the overall population. We have previously proposed a marginalized two-part model that yields more interpretable effect estimates by parameterizing the model in terms of the marginal mean...
January 1, 2018: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/29450585/effect-of-isolated-vitamin-d-supplementation-on-bone-turnover-markers-in-younger-postmenopausal-women-a-randomized-double-blind-placebo-controlled-trial
#6
J Nahas-Neto, L M Cangussu, C L Orsatti, F N Bueloni-Dias, P F Poloni, E B Schmitt, E A P Nahas
Vitamin D (VD) plays an important role in bone mineralization. The present study investigates the effect of VD supplementation alone on bone turnover markers in younger postmenopausal women. It has been shown that VD supplementation in postmenopausal women with hypovitaminosis D is associated with a reduction in bone turnover markers. PURPOSE: The purpose of this study is to evaluate the effect of VD supplementation alone on bone turnover markers in younger postmenopausal women. METHODS: In this double-blind, placebo-controlled trial, 160 women were randomized into the VD group (supplementation with 1000 IU of vitamin D3/day, orally; n = 80) or placebo group (n = 80)...
February 15, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29450147/lemongrass-cymbopogon-flexuosus-essential-oil-demonstrated-anti-inflammatory-effect-in-pre-inflamed-human-dermal-fibroblasts
#7
Xuesheng Han, Tory L Parker
Lemongrass ( Cymbopogon flexuosus ) essential oil (LEO), which has citral as its main component, has exhibited anti-inflammatory effect in both animal and human cells. In this study, we evaluated the anti-inflammatory activity of a commercially available LEO in pre-inflamed human dermal fibroblasts. We first studied the impact of LEO on 17 protein biomarkers that are critically associated with inflammation and tissue remodeling. LEO significantly inhibited production of the inflammatory biomarkers vascular cell adhesion molecule 1 (VCAM-1), interferon gamma-induced protein 10 (IP-10), interferon-inducible T-cell alpha chemoattractant (I-TAC), and monokine induced by gamma interferon (MIG); decreased levels of the tissue remodeling biomarkers collagen-I and III, epidermal growth factor receptor (EGFR), and plasminogen activator inhibitor (PAI-1); and inhibited the immunomodulatory biomarker macrophage colony-stimulating factor (M-CSF)...
June 2017: Biochimie Open
https://www.readbyqxmd.com/read/29450144/anti-inflammatory-tissue-remodeling-immunomodulatory-and-anticancer-activities-of-oregano-origanum-vulgare-essential-oil-in-a-human-skin-disease-model
#8
Xuesheng Han, Tory L Parker
The use of oregano ( Origanum vulgare ) essential oil (OEO) has become popular in skin care products. However, scientific research regarding its effects on human skin cells is scarce. In this study, we investigated the biological activity of a commercially available OEO, which is high in carvacrol content, in a human skin cell disease model. OEO induced marked antiproliferative effects and significantly inhibited several inflammatory biomarkers, including monocyte chemoattractant protein 1 (MCP-1), vascular cell adhesion molecule 1 (VCAM-1), intracellular cell adhesion molecule 1 (ICAM-1), interferon gamma-induced protein 10 (IP-10), interferon-inducible T-cell alpha chemoattractant (I-TAC), and monokine induced by gamma interferon (MIG)...
June 2017: Biochimie Open
https://www.readbyqxmd.com/read/29450142/arborvitae-thuja-plicata-essential-oil-significantly-inhibited-critical-inflammation-and-tissue-remodeling-related-proteins-and-genes-in-human-dermal-fibroblasts
#9
Xuesheng Han, Tory L Parker
Arborvitae ( Thuja plicata ) essential oil (AEO) is becoming increasingly popular in skincare, although its biological activity in human skin cells has not been investigated. Therefore, we sought to study AEO's effect on 17 important protein biomarkers that are closely related to inflammation and tissue remodeling by using a pre-inflamed human dermal fibroblast culture model. AEO significantly inhibited the expression of vascular cell adhesion molecule 1 (VCAM-1), intracellular cell adhesion molecule 1 (ICAM-1), interferon gamma-induced protein 10 (IP-10), interferon-inducible T-cell chemoattractant (I-TAC), monokine induced by interferon gamma (MIG), and macrophage colony-stimulating factor (M-CSF)...
June 2017: Biochimie Open
https://www.readbyqxmd.com/read/29450138/biological-activities-of-frankincense-essential-oil-in-human-dermal-fibroblasts
#10
Xuesheng Han, Damian Rodriguez, Tory L Parker
Although frankincense essential oil (FREO) has become increasingly popular in skin care, research on its biological activities in human skin cells is scarce, if not completely absent. In the current study, we explored the biological activities of FREO in pre-inflamed human dermal fibroblasts by analyzing the levels of 17 important protein biomarkers pertinent to inflammation and tissue remodeling. FREO exhibited robust anti-proliferative activity in these skin cells. It also significantly inhibited collagen III, interferon gamma-induced protein 10, and intracellular cell adhesion molecule 1...
June 2017: Biochimie Open
https://www.readbyqxmd.com/read/29449830/screening-for-ppar-non-agonist-ligands-followed-by-characterization-of-a-hit-am-879-with-additional-no-adipogenic-and-cdk5-mediated-phosphorylation-inhibition-properties
#11
Helder Veras Ribeiro Filho, Natália Bernardi Videira, Aline Villanova Bridi, Thais Helena Tittanegro, Fernanda Aparecida Helena Batista, José Geraldo de Carvalho Pereira, Paulo Sérgio Lopes de Oliveira, Marcio Chaim Bajgelman, Albane Le Maire, Ana Carolina Migliorini Figueira
Peroxisome proliferator-activated receptor gamma (PPARγ) is a member of a nuclear receptor superfamily and acts as a ligand-dependent transcription factor, playing key roles in maintenance of adipose tissue and in regulation of glucose and lipid homeostasis. This receptor is the target of thiazolidinediones, a class of antidiabetic drugs, which improve insulin sensitization and regulate glycemia in type 2 diabetes. Despite the beneficial effects of drugs, such as rosiglitazone and pioglitazone, their use is associated with several side effects, including weight gain, heart failure, and liver disease, since these drugs induce full activation of the receptor...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29449429/heterogeneous-origins-of-human-sleep-spindles-in-different-cortical-layers
#12
Donald J Hagler, Istvan Ulbert, Lucia Wittner, Lorand Erőss, Joseph R Madsen, Orrin Devinsky, Werner Doyle, Daniel Fabo, Sydney S Cash, Eric Halgren
Sleep spindles are a cardinal feature in human NREM sleep and may be important for memory consolidation. We studied the intracortical organization of spindles in men and women by recording spontaneous sleep spindles from different cortical layers using linear microelectrode arrays. Two patterns of spindle generation were identified using visual inspection, and confirmed with factor analysis. Spindles (10-16Hz) were largest and most common in upper and middle channels, with limited involvement of deep channels...
February 15, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29448959/impaired-t-cell-mediated-hepatitis-in-peroxisome-proliferator-activated-receptor-alpha-ppar%C3%AE-deficient-mice
#13
Ian N Hines, Michael Kremer, Sherri M Moore, Michael D Wheeler
BACKGROUND: Peroxisome proliferator activated receptor alpha (PPARα), a regulator of enzymes involved in β oxidation, has been reported to influence lymphocyte activation. The purpose of this study was to determine whether PPARα plays a role in T cell-mediated hepatitis induced by Concanavalin A (ConA). METHODS: Wild type (wt) or PPARα-deficient (PPARα -/- ) mice were treated with ConA (15 mg/kg) by intravenous injection 0, 10 or 24 h prior to sacrifice and serum and tissue collection for analysis of tissue injury, cytokine response, T cell activation and characterization...
February 15, 2018: Biological Research
https://www.readbyqxmd.com/read/29448432/effect-of-particle-stiffness-on-contact-dynamics-and-rheology-in-a-dense-granular-flow
#14
S Bharathraj, V Kumaran
Dense granular flows have been well described by the Bagnold rheology, even when the particles are in the multibody contact regime and the coordination number is greater than 1. This is surprising, because the Bagnold law should be applicable only in the instantaneous collision regime, where the time between collisions is much larger than the period of a collision. Here, the effect of particle stiffness on rheology is examined. It is found that there is a rheological threshold between a particle stiffness of 10^{4}-10^{5} for the linear contact model and 10^{5}-10^{6} for the Hertzian contact model above which Bagnold rheology (stress proportional to square of the strain rate) is valid and below which there is a power-law rheology, where all components of the stress and the granular temperature are proportional to a power of the strain rate that is less then 2...
January 2018: Physical Review. E
https://www.readbyqxmd.com/read/29448391/relationship-between-the-mechanisms-of-gamma-rhythm-generation-and-the-magnitude-of-the-macroscopic-phase-response-function-in-a-population-of-excitatory-and-inhibitory-modified-quadratic-integrate-and-fire-neurons
#15
Akihiko Akao, Yutaro Ogawa, Yasuhiko Jimbo, G Bard Ermentrout, Kiyoshi Kotani
Gamma oscillations are thought to play an important role in brain function. Interneuron gamma (ING) and pyramidal interneuron gamma (PING) mechanisms have been proposed as generation mechanisms for these oscillations. However, the relation between the generation mechanisms and the dynamical properties of the gamma oscillation are still unclear. Among the dynamical properties of the gamma oscillation, the phase response function (PRF) is important because it encodes the response of the oscillation to inputs...
January 2018: Physical Review. E
https://www.readbyqxmd.com/read/29448182/enhanced-alumina-recovery-from-secondary-aluminum-dross-for-high-purity-nanostructured-%C3%AE-alumina-powder-production-kinetic-study
#16
Mostafa Mahinroosta, Ali Allahverdi
The numerous ecological problems caused by the accumulation of secondary aluminum dross (SAD) as a hazardous waste generated in aluminum castings have necessitated a need for a sustainable recycling solution. This study proposes a novel and green leaching-based process for recovery of nano-alumina as a highly valuable material from SAD. The leaching phase was performed at atmospheric pressure and low temperature. To obtain optimum conditions for the recovery process, the dissolution kinetics and mechanism of SAD in hydrochloric acid were initially studied under a given liquid-to-solid ratio of 20 ml/g, various reaction temperatures and times...
February 12, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29447903/mass-spectrometric-identification-of-bromotryptophan-containing-conotoxin-sequences-from-the-venom-of-c-amadis
#17
M Vijayasarathy, P Balaram
Four 30 residue conotoxin have been identified from the venom of C. amadis. MS/MS analysis of crude venom subjected to global reduction/alkylation yielded fragmentation patterns, which permitted searching and matching with a database of putative mature toxin sequences obtained from transcriptomic analysis. Of the four sequences identified, Am3408(Am6.1b), Am3452(Am6.1c), Am3136(Am6.2a) and Am3214(Am6.2b), three contain bromotryptophan residues, while an additional post translational modification, gamma carboxylation of glutamic acid, is present in Am3408(Am6...
February 12, 2018: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29447636/a-diagnostically-challenging-case-of-cd8-primary-cutaneous-gamma-delta-t-cell-lymphoma
#18
Michelle A Pitch, Kevin H Kim, Trey Manning, Bruce R Smoller, Henry K Wong, Jennifer R Kaley
Primary cutaneous gamma/delta T-cell lymphoma (PCγδTCL) is a rare form of cutaneous lymphoma characterized by abnormal clonal proliferation of mature, activated gamma-delta T cells expressing the γδ heterodimer of the T-cell receptor (TCR). As an entity, PCγδTCL has recently undergone diagnostic revision since its introduction in the 2008 WHO classification of cutaneous lymphomas and confirmedin 2016. Nonetheless, diagnosis remains difficult both clinically and histologically, given its broad range of clinical manifestations and immunohistochemical phenotypes...
November 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29447591/characterization-of-a-partial-body-irradiation-model-with-oral-cavity-shielding-in-non-human-primates
#19
Michael V Accardi, Oreola Donini, Adam Rumage, Alexis Ascah, Julius Haruna, Mylène Pouliot, Kim Bujold, Hai Haung, Wieslaw Wierzbicki, John Stamatopoulos, Houman Naraghi, Thomas Measey, Simon Authier
PURPOSE: Characterization of a novel partial body irradiation (PBI) shielding strategy in nonhuman primates (NHP; rhesus macaques), aimed at protecting the oral cavity, with respect to various gastrointestinal (GI-ARS) syndrome parameters as well as buccal ulceration development. MATERIALS AND METHODS: NHPs were irradiated using a Cobalt-60 gamma source, in a single uniform dose, ranging from 9-13 Gy and delivered at 0.60-0.80 Gy min -1 . Animals were either partially shielded via oral cavity shielding (PBI OS ) or underwent total body irradiation (TBI)...
February 15, 2018: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/29446623/photo-controlled-coumarin-diphenylalanine-cyclodextrin-cross-linking-of-1d-nanofibers-to-2d-thin-films
#20
Ni Cheng, Yong Chen, Jie Yu, Jing-Jing Li, Yu Liu
Using coumarin-modified diphenylalanine (CO-FF) and gamma-cyclodextrin (gamma-CD) as building blocks, one-dimensional nanofibers with several nanometers in width and tens of micrometers in length were successfully constructed. Through the photo-dimerization of coumarin units in CO-FF/gamma-CD complexes, the resultant nanofibers could cross-linked to organic 2D thin films with a lateral dimension of tens of micrometers and a thickness of nanometers. The resultant thin films exhibited a sig-nificant fluorescence enhancement for twisted intramolecular charge-transfer (TICT) molecules and effective removal of pollut-ant from water through filtration...
February 15, 2018: ACS Applied Materials & Interfaces
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