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https://www.readbyqxmd.com/read/28108979/analysis-of-stress-only-imaging-comparing-upright-and-supine-czt-camera-acquisition-to-conventional-gamma-camera-images-with-and-without-attenuation-correction-with-coronary-angiography-as-a-reference
#1
Zenith A Jameria, Mouhamad Abdallah, Mariano Fernandez-Ulloa, Robert O'Donnell, Alok K Dwivedi, Erica Washburn, Naseer Khan, Mahyar Khaleghi, Nischelle Kalakota, Myron C Gerson
BACKGROUND: Diagnostic performance of stress-only imaging using a Cadmium-Zinc-Telluride (CZT) camera has not been directly compared in the same patients to stress-only attenuation-corrected conventional Anger camera images. METHODS: 112 subjects with correlative coronary angiographic data and 40 subjects with <5% pre-test likelihood of coronary disease completed attenuation-corrected stress-only images on a conventional Anger camera and uncorrected upright and supine stress images on a CZT camera...
January 20, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28108749/deinococcus-malanensis-sp-nov-isolated-from-radiation-polluted-soil
#2
Jing Zhu, Shan-Hui Li, Qi-Yong Tang, Min Chu, Wei Wang, Nimaichand Salam, Li Li, Wael N Hozzein, Zhi-Dong Zhang, Wen-Jun Li
A Gram-staining positive, non-spore forming, short rod-shaped and coccus-shaped, non-motile, pink-colored, gamma- and UV-resistant strain, designated T93(T) was isolated from soil of Malan area in Xinjiang Uyghur Autonomous Region, Northwest China. The taxonomic position of the new isolate was determined using a polyphasic approach. Strain T93(T) shared the highest 16 S rRNA gene sequence similarity with Deinococcus deserti VCD115(T) (97.54%). The genomic DNA G+C content of the isolate T93(T) was 61.7 mol%...
January 20, 2017: Archives of Microbiology
https://www.readbyqxmd.com/read/28108427/treatment-of-non-functional-pituitary-adenoma-post-operative-remnants-adjuvant-or-delayed-gamma-knife-radiosurgery
#3
Z H A Sadik, E H J Voormolen, P R A M Depauw, B Burhani, W A Nieuwlaat, J Verheul, S Leenstra, R Fleischeuer, P E J Hanssens
OBJECTIVE: It is still not clear whether Gamma knife Radiosurgery (GKRS) for non-functional pituitary adenomas (NFPA) should be used as a standard adjuvant postoperative therapy or applied when there is documented progression of the remnant on the follow-up (FU) MRI. METHODS: We performed a retrospective study of patients with non-functional pituitary adenomas who underwent primary surgery and GKRS between 2002 and 2015. Patients were divided into two groups based on the GKRS indication: adjuvant treatment (GKRS ≤6 months postoperatively) or delayed treatment (GKRS if documented progression occurred on the FU MRI)...
January 17, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28108187/application-of-an-artificial-neural-network-for-evaluation-of-activity-concentration-exemption-limits-in-norm-industry
#4
Hannah Wiedner, Virginia Peyrés, Teresa Crespo, Marcos Mejuto, Eduardo García-Toraño, Franz Josef Maringer
NORM emits many different gamma energies that have to be analysed by an expert. Alternatively, artificial neural networks (ANNs) can be used. These mathematical software tools can generalize "knowledge" gained from training datasets, applying it to new problems. No expert knowledge of gamma-ray spectrometry is needed by the end-user. In this work an ANN was created that is able to decide from the raw gamma-ray spectrum if the activity concentrations in a sample are above or below the exemption limits.
December 27, 2016: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28108100/three-dimensional-quality-assurance-of-imrt-prostate-plans-using-gel-dosimetry
#5
M A Silveira, J F Pavoni, O Baffa
Intensity modulated radiotherapy (IMRT) is one of the most modern radiation therapy treatment techniques. Although IMRT can deliver high and complex conformational doses to the tumor volume, its implementation requires rigorous quality assurance (QA) procedures that include a dosimetric pre-treatment verification of individual patient planning. This verification usually involves measuring a small volume of absolute dose with an ionization chamber and checking bi-dimensional fluency with an array of detectors...
January 17, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28108005/in-vitro-allogeneic-immune-cell-response-to-mesenchymal-stromal-cells-derived-from-human-adipose-in-patients-with-rheumatoid-arthritis
#6
P Usha Shalini, J V S Vidyasagar, Lakshmi Kumari Kona, Meenakshi Ponnana, Lakshmi Kiran Chelluri
We investigated the regulatory activity of human adipose-derived mesenchymal stromal cells (MSCs) (n=10) towards immune cells in a cohort of 84 rheumatoid arthritis (RA) patients, 36 apparently healthy controls. We co-cultured MSCs with lymphocyte subsets of T, B, and T regulatory cells (Tregs). Levels of the pro- and anti-inflammatory markers (tumor necrosis factor alpha (TNF-α), interferon gamma (IFN-γ), and interleukin-10 (IL-10)) were estimated in serum and co-culture supernatants. The study revealed a two-fold increase in the proportion of Tregs and an increased level of CD4(+)CD25(+)FoxP3...
January 12, 2017: Cellular Immunology
https://www.readbyqxmd.com/read/28107996/the-stability-of-tnt-rdx-and-petn-in-simulated-post-explosion-soils-implications-of-sample-preparation-for-analysis
#7
H A Yu, D A DeTata, S W Lewis, N Nic Daeid
Explosives residues in soils may be a useful source of evidence following the detonation of an improvised explosive device (IED), such as a vehicle-borne IED. Soil samples collected from the vicinity of an explosion scene will often be stored for some time prior to analysis, yet explosives residues in soil samples are susceptible to rapid degradation or transformation. Although some research has assessed the use of different storage temperatures with a view to reducing explosives' degradation over time, further research examining the degradation of explosives in soil when stored under a variety of storage conditions is crucial to determine the optimal sample collection and storage procedures for soil containing explosives residues...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/28107809/plasma-protein-profiling-for-potential-biomarkers-in-the-early-diagnosis-of-alzheimer-s-disease
#8
Yuki Kitamura, Ryoko Usami, Sahoko Ichihara, Hirotaka Kida, Masayuki Satoh, Hidekazu Tomimoto, Mariko Murata, Shinji Oikawa
OBJECTIVES: Alzheimer's disease (AD) is the most common cause of dementia in elderly persons. Since the pathology of AD develops slowly from a preclinical or early phase into a fully expressed clinical syndrome, at the time of diagnosis the disease has been progressing for many years. To facilitate the early diagnosis of AD, we performed protein profiling of blood in patients with mild AD as defined by the Functional Assessment Staging (FAST) scale. METHODS: Plasma samples from mild AD patients and healthy controls were analyzed using two-dimensional differential gel electrophoresis (2D-DIGE) combined with matrix-assisted laser desorption ionization time-of-flight tandem mass spectrometry (MALDI-TOF/TOF/MS) followed by peptide mass fingerprinting...
January 20, 2017: Neurological Research
https://www.readbyqxmd.com/read/28107769/the-transcriptional-modulator-ifrd1-controls-pgc-1%C3%AE-expression-under-short-term-adrenergic-stimulation-in-brown-adipocytes
#9
Gyujin Park, Tetsuhiro Horie, Takashi Kanayama, Kazuya Fukasawa, Takashi Iezaki, Yuki Onishi, Kakeru Ozaki, Yukari Nakamura, Yukio Yoneda, Takeshi Takarada, Eiichi Hinoi
Sympathetic tone activates the function of classical brown adipocytes, which constitutively exist in the brown adipose tissue, and inducible brown adipocytes (so-called beige adipocytes), which sporadically reside within the white adipose tissue. Here we identified the transcriptional modulator interferon-related developmental regulator 1 (Ifrd1) as a negative regulator of thermogenic and mitochondrial gene expression in brown adipocytes. Ifrd1 expression was markedly induced by cold exposure and administration of CL-316243 (a β3 adrenergic agonist) in interscapular brown adipose and inguinal subcutaneous white adipose tissues, but not in epididymal visceral white adipose tissue, in vivo...
January 20, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28107685/a-monte-carlo-modeling-alternative-for-the-api-gamma-ray-calibration-facility
#10
J E Galford
The gamma ray pit at the API Calibration Facility, located on the University of Houston campus, defines the API unit for natural gamma ray logs used throughout the petroleum logging industry. Future use of the facility is uncertain. An alternative method is proposed to preserve the gamma ray API unit definition as an industry standard by using Monte Carlo modeling to obtain accurate counting rate-to-API unit conversion factors for gross-counting and spectral gamma ray tool designs.
January 12, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28107600/the-predictive-and-prognostic-role-of-serum-neopterin-and-tryptophan-breakdown-in-prostate-cancer
#11
Renate Pichler, Josef Fritz, Isabel Heidegger, Eberhard Steiner, Zoran Culig, Helmut Klocker, Dietmar Fuchs
The Interferon-gamma induced enzymes indoleamine 2,3-dioxygenase and GTP-cylohydrolase are key players in tumor immune escape mechanisms. We quantified serum levels of neopterin and tryptophan breakdown (tryptophan, kynurenine and kynurenine-to-tryptophan ratio) in addition to prostate-specific antigen (PSA) in newly diagnosed prostate cancer (PCa) patients (n=100) before radical prostatectomy (RP) as well as at time of biochemical recurrence (BCR) after RP (n=50) in comparison to healthy men (n=49). Effects of biomarkers on the risk of PCa diagnosis on transrectal biopsy, worse histopathological characteristics of the RP specimens and cancer-specific survival (CSS) after BCR were investigated...
January 20, 2017: Cancer Science
https://www.readbyqxmd.com/read/28106957/the-influence-of-habitat-heterogeneity-and-latitude-on-gamma-diversity-of-the-nearctic-simuliidae-a-ubiquitous-group-of-stream-dwelling-insects
#12
John W McCreadie, Rachel H Williams, Sam Stutsman, Debra S Finn, Peter H Adler
Among the most prominent, large-scale patterns of species richness are the increases in richness with decreasing latitude and with increasing habitat heterogeneity. Using the stream-dwelling larval and pupal stages of North American black flies (Diptera: Simuliidae), we address three broad questions about species richness: (i) Does a significant latitude-richness relationship exist? (ii) How does habitat heterogeneity influence gamma diversity? (iii) What is the sign (positive or negative) of the latitude-richness and the heterogeneity-richness relationships? We found no evidence that habitat heterogeneity influences gamma diversity...
January 20, 2017: Insect Science
https://www.readbyqxmd.com/read/28106928/diagnostic-considerations-for-cholestatic-liver-disease
#13
REVIEW
Galia Pollock, Gerald Y Minuk
Cholestatic liver disease results from insufficient bile synthesis, secretion and/or flow through the biliary tract. Common presenting features include fatigue, pruritus and cholestatic liver enzyme abnormalities wherein elevations of serum alkaline phosphatase and gamma-glutamyltransferases levels exceed those of alanine and aspartate aminotransferases. With prolonged cholestasis, fat soluble vitamin deficiencies, fibrosis, cirrhosis and on occasion, carcinoma of the biliary tract or liver can occur. Once mechanical obstruction to bile flow has been ruled out, the majority of causes can be classified as immune-mediated, infectious or miscellaneous...
January 20, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28106567/fractional-anisotropy-and-mean-diffusion-as-measures-of-dopaminergic-function-in-parkinson-s-disease-challenging-results
#14
Niklas Lenfeldt, Johan Eriksson, Björn Åström, Lars Forsgren, Susanna Jakobson
BACKGROUND: Diffusion tensor imaging (DTI) has been purported as an imaging technique to assess dopaminergic degeneration in Parkinson's disease. OBJECTIVE: To test if fractional anisotropy (FA) and mean diffusion (MD) in the basal ganglia as measured by DTI correlates with dopaminergic function as measured by dopamine transporter (DAT) and dopamine D2-receptor (D2R) SPECT. METHODS: One-hundred and eleven patients with Parkinson's disease (71±10 years) and thirty-one controls (68±7 years) performed DTI, DAT and D2R SPECT at baseline and four follow-ups (1-year: 89 patients/zero controls; 3-year: 72/11; 5-year: 48/17; and 8-year: 13/13)...
January 17, 2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28106495/comparison-of-prognostic-indices-in-patients-who-undergo-melanoma-brain-metastasis-radiosurgery
#15
Hideyuki Kano, Alejandro Morales-Restrepo, Aditya Iyer, Gregory M Weiner, Seyed H Mousavi, John M Kirkwood, Ahmad A Tarhini, John C Flickinger, L Dade Lunsford
OBJECTIVE The goal of this study was to use 4 prognostic indices to compare survival times of patients who underwent Gamma Knife stereotactic radiosurgery (SRS) to treat melanoma brain metastases. METHODS The authors analyzed 422 consecutive patients (1440 brain metastases) who underwent Gamma Knife SRS. The median total brain tumor volume was 4.7 cm(3) (range 0.3-69.3 cm(3)), and the median number of metastases was 2 (range 1-32). One hundred thirty-two patients underwent whole-brain radiation therapy. Survival times were compared using recursive partitioning analysis (RPA), the Score Index for Radiosurgery (SIR), the Basic Score for Brain Metastases (BSBM), and the Diagnosis-Specific Graded Prognostic Assessment (DS-GPA)...
January 20, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28106446/exacerbating-the-cosmological-constant-problem-with-interacting-dark-energy-models
#16
M C David Marsh
Future cosmological surveys will probe the expansion history of the Universe and constrain phenomenological models of dark energy. Such models do not address the fine-tuning problem of the vacuum energy, i.e., the cosmological constant problem (CCP), but can make it spectacularly worse. We show that this is the case for "interacting dark energy" models in which the masses of the dark matter states depend on the dark energy sector. If realized in nature, these models have far-reaching implications for proposed solutions to the CCP that require the number of vacua to exceed the fine-tuning of the vacuum energy density...
January 6, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28105940/integrated-single-cell-data-analysis-reveals-cell-specific-networks-and-novel-coactivation-markers
#17
Shila Ghazanfar, Adam J Bisogni, John T Ormerod, David M Lin, Jean Y H Yang
BACKGROUND: Large scale single cell transcriptome profiling has exploded in recent years and has enabled unprecedented insight into the behavior of individual cells. Identifying genes with high levels of expression using data from single cell RNA sequencing can be useful to characterize very active genes and cells in which this occurs. In particular single cell RNA-Seq allows for cell-specific characterization of high gene expression, as well as gene coexpression. RESULTS: We offer a versatile modeling framework to identify transcriptional states as well as structures of coactivation for different neuronal cell types across multiple datasets...
December 5, 2016: BMC Systems Biology
https://www.readbyqxmd.com/read/28104778/probiotic-strains-modulate-cytokine-production-and-the-immune-interplay-between-human-peripheral-blood-mononucear-cells-and-colon-cancer-cells
#18
Meir Djaldetti, Hanna Bessler
BACKGROUND: Human health is tightly connected with a great number of gut microbial cells designated as microbiome or microbiota. We have examined the effect of six microbial strains (MS) included in a commercial probiotic on cytokine production by human peripheral blood mononuclear cells (PBMC) and on their immune dialog with colon carcinoma cells. METHODS: Non-stimulated and lipopolysaccharide (LPS) stimulated PBMC were incubated for 24 hours with MS. The secretion of tumor necrosis factor alpha (TNFα), IL-1β, IL-6, interferon gamma (IFNγ), IL-10, and IL-1ra, as well as the effect of MS on the immune interplay between PBMC and cells from HT-29 and RKO colon carcinoma lines were evaluated...
January 18, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/28104608/prothrombin-loading-of-vascular-smooth-muscle-cell-derived-exosomes-regulates-coagulation-and-calcification
#19
Alexander N Kapustin, Michael Schoppet, Leon J Schurgers, Joanne L Reynolds, Rosamund McNair, Alexander Heiss, Willi Jahnen-Dechent, Tilman M Hackeng, Georg Schlieper, Paul Harrison, Catherine M Shanahan
OBJECTIVE: The drug warfarin blocks carboxylation of vitamin K-dependent proteins and acts as an anticoagulant and an accelerant of vascular calcification. The calcification inhibitor MGP (matrix Gla [carboxyglutamic acid] protein), produced by vascular smooth muscle cells (VSMCs), is a key target of warfarin action in promoting calcification; however, it remains unclear whether proteins in the coagulation cascade also play a role in calcification. APPROACH AND RESULTS: Vascular calcification is initiated by exosomes, and proteomic analysis revealed that VSMC exosomes are loaded with Gla-containing coagulation factors: IX and X, PT (prothrombin), and proteins C and S...
January 19, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28104448/metformin-and-low-dose-radiation-modulates-cisplatin-induced-oxidative-injury-in-rat-via-ppar-%C3%AE-and-mapk-pathways
#20
Heba H Mansour, Shereen M El Kiki, Shereen M Galal
: Cisplatin (CIS) is a chemotherapeutic agent used for therapy of many tumors and has been limited by its toxicity. The aim of this study was to investigate the role of Peroxisome proliferator-activated receptor-gamma (PPAR-γ), mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B(NFkB) in the pathogenesis of hepatic damage induced by CIS, and investigated the modulatory effect of metformin (MET) and/or low dose gamma radiation (LDR) on CIS-induced hepatotoxicity in rats...
January 16, 2017: Archives of Biochemistry and Biophysics
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