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https://www.readbyqxmd.com/read/29928999/a-potentially-important-role-for-t-cells-and-regulatory-t-cells-in-langerhans-cell-histiocytosis
#1
REVIEW
Jenée M Mitchell, Stuart P Berzins, George Kannourakis
Langerhans cell histiocytosis is characterized by lesions containing inflammatory immune cells, including myeloid cells and T cells. Patient mortality remains unacceptably high and new treatment options are required. Several LCH studies have identified aberrant frequencies of T cell subsets with potential immune regulatory properties. High numbers of Foxp3+ regulatory T cells and gamma-delta T cells have been reported in patients with LCH, although, the cause of their presence or their significance is not yet clear...
June 18, 2018: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/29928634/evaluation-of-targeted-image-guided-radiation-therapy-treatment-planning-system-by-use-of-american-association-of-physicists-in-medicine-task-group-119-test-cases
#2
Mohsen Saeb, Daryoush Shahbazi-Gahrouei, Shahram Monadi
Background: This study aimed to evaluate the overall accuracy of the beam commissioning criteria of targeted image-guided radiation therapy (TiGRT) treatment planning system (TPS) based on the American Association of Physicists in Medicine (AAPM) Task Group Report 119 (TG-119). Methods: The work was performed using 6 MV energy LINAC with a variable dose rate of 200 MU/min which equipped with the high-quality external TiGRT dynamic multileaf collimator model H. The AAPM TG-119 intensity-modulated radiation therapy (IMRT) commissioning tests are composed of two preliminary tests and four clinical test cases...
April 2018: Journal of Medical Signals and Sensors
https://www.readbyqxmd.com/read/29928182/a-novel-mgp-gene-mutation-causing-keutel-syndrome-in-a-brazilian-patient
#3
Eduardo Perrone, Kelin Chen, Marco Ramos, Maria Fernanda Milanezi, Viviane Nakano, Ariane Falconi, Juliana Silva, Jamille Campos, Celia M C Silva, Joao B O Filho, Ana B A Perez
Keutel syndrome is caused by mutations in the matrix gamma-carboxyglutamic acid ( MGP ) gene (OMIM 154870) and is inherited in an autosomal recessive fashion. It is characterized by brachydactyly, pulmonary artery stenosis, a distinctive facial phenotype, and cartilage calcification. To date, only 36 cases have been reported worldwide. We describe clinical and molecular findings of the first Brazilian patient with Keutel syndrome. Keutel syndrome was suspected based on clinical and morphological evaluation, so we sequenced the MGP gene using the TruSight One Sequencing Panel (Illumina)...
May 2018: Molecular Syndromology
https://www.readbyqxmd.com/read/29927251/bioreducible-polymeric-nanoparticles-containing-multiplexed-cancer-stem-cell-regulating-mirnas-inhibit-glioblastoma-growth-and-prolong-survival
#4
Hernando Lopez-Bertoni, Kristen Kozielski, Yuan Rui, Bachchu Lal, Hannah Vaughan, David Wilson, Nicole Mihelson, Charles Eberhart, John Laterra, Jordan J Green
Despite our growing molecular understanding of glioblastoma (GBM), treatment modalities remain limited. Recent developments in mechanisms of cell fate regulation and nanomedicine provide new avenues to treat and manage brain tumors via delivery of molecular therapeutics. Here we have developed bioreducible poly(beta-amino ester) nanoparticles that demonstrate high intracellular delivery efficacy, low cytotoxicity, escape from endosomes, and promotion of cytosol-targeted environmentally-triggered cargo release for miRNA delivery to tumor-propagating human cancer stem cells...
June 21, 2018: Nano Letters
https://www.readbyqxmd.com/read/29927105/use-of-axenic-culture-tools-to-study-coxiella-burnetii
#5
Savannah E Sanchez, Eduardo Vallejo-Esquerra, Anders Omsland
Coxiella burnetii is a highly infectious obligate intracellular bacterium and the etiological agent of the zoonosis Query (Q) fever. This Gram-negative gamma-proteobacterium has adapted to replicate within a specialized compartment in mammalian phagocytic cells, known as the Coxiella-containing vacuole (CCV). Knowledge of critical characteristics of the CCV microenvironment (e.g., luminal pH), analysis of the C. burnetii genome sequence, and strategic metabolic profiling have provided the basis for determining the physicochemical and nutritional conditions necessary to support axenic replication of C...
May 18, 2018: Current Protocols in Microbiology
https://www.readbyqxmd.com/read/29926649/-effects-of-simulated-100-m-trimix-conventional-diving-on-oxidative-stress-and-inflammatory-reaction-in-rabbits
#6
Yang-Yang Li, Lu Shi, Yan-Meng Zhang, Chan-Juan Xiao, Hong-Tao Liu
OBJECTIVE: To investigate the effects of simulated 100 m Trimix conventional diving on tissue inflammatory cytokines in rabbits. METHODS: Eight New Zealand rabbits were performed a simulated 100 m Trimix conventional diving program which was established according to the Haldane theory. The expression levels of interferon-gamma(IFN- γ ), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-8 (IL-8), myeloperoxidase(MPO) and matrix metallo proteinase-9 (MMP-9) in rabbits lung and brain tissues were detected by Elisa after diving decompression...
January 8, 2018: Chinese Journal of Applied Physiology
https://www.readbyqxmd.com/read/29926339/immunological-role-of-cd4-cd28-null-t-lymphocytes-natural-killer-cells-and-interferon-gamma-in-pediatric-patients-with-sickle-cell-disease-relation-to-disease-severity-and-response-to-therapy
#7
Mohsen Saleh ElAlfy, Amira Abdel Moneam Adly, Fatma Soliman ElSayed Ebeid, Deena Samir Eissa, Eman Abdel Rahman Ismail, Yasser Hassan Mohammed, Manar Elsayed Ahmed, Aya Sayed Saad
Sickle cell disease (SCD) is associated with alterations in immune phenotypes. CD4+ CD28null T lymphocytes have pro-inflammatory functions and are linked to vascular diseases. To assess the percentage of CD4+ CD28null T lymphocytes, natural killer cells (NK), and IFN-gamma levels, we compared 40 children and adolescents with SCD with 40 healthy controls and evaluated their relation to disease severity and response to therapy. Patients with SCD steady state were studied, focusing on history of frequent vaso-occlusive crisis, hydroxyurea therapy, and IFN-gamma levels...
June 20, 2018: Immunologic Research
https://www.readbyqxmd.com/read/29925775/inulin-supplementation-does-not-reduce-plasma-trimethylamine-n-oxide-concentrations-in-individuals-at-risk-for-type-2-diabetes
#8
Mary Elizabeth Baugh, Cortney N Steele, Christopher J Angiletta, Cassie M Mitchell, Andrew P Neilson, Brenda M Davy, Matthew W Hulver, Kevin P Davy
Trimethylamine N -oxide (TMAO) is associated with type 2 diabetes (T2DM) and increased risk of adverse cardiovascular events. Prebiotic supplementation has been purported to reduce TMAO production, but whether prebiotics reduce fasting or postprandial TMAO levels is unclear. Sedentary, overweight/obese adults at risk for T2DM ( n = 18) were randomized to consume a standardized diet (55% carbohydrate, 30% fat) with 10 g/day of either an inulin supplement or maltodextrin placebo for 6 weeks. Blood samples were obtained in the fasting state and hourly during a 4-h high-fat challenge meal (820 kcal; 25% carbohydrate, 63% fat; 317...
June 20, 2018: Nutrients
https://www.readbyqxmd.com/read/29925772/lead-pb-exposure-enhances-expression-of-factors-associated-with-inflammation
#9
REVIEW
Emilia Metryka, Karina Chibowska, Izabela Gutowska, Anna Falkowska, Patrycja Kupnicka, Katarzyna Barczak, Dariusz Chlubek, Irena Baranowska-Bosiacka
The human immune system is constantly exposed to xenobiotics and pathogens from the environment. Although the mechanisms underlying their influence have already been at least partially recognized, the effects of some factors, such as lead (Pb), still need to be clarified. The results of many studies indicate that Pb has a negative effect on the immune system, and in our review, we summarize the most recent evidence that Pb can promote inflammatory response. We also discuss possible molecular and biochemical mechanisms of its proinflammatory action, including the influence of Pb on cytokine metabolism (interleukins IL-2, IL-4, IL-8, IL-1b, IL-6), interferon gamma (IFNγ), and tumor necrosis factor alpha (TNF-α); the activity and expression of enzymes involved in the inflammatory process (cyclooxygenases); and the effect on selected acute phase proteins: C-reactive protein (CRP), haptoglobin, and ceruloplasmin...
June 20, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29925751/-effects-of-low-mu-in-respiratory-gated-imrt-on-mlc-position-accuracy-and-dose-distribution
#10
Kazuyoshi Kanai, Kazuki Kotabe, Koutarou Kijima, Yui Yamada, Yoshikazu Takahashi, Hidetsugu Nakayama
PURPOSE: The purpose of this research is to clarify the effects of low monitor unit (MU) on multileaf collimator (MLC) position accuracy and dose distribution in intensity modulated radiotherapy (IMRT) using respiratory gated. METHOD: In the phantom experiment, irradiation without respiratory gated and respiratory gated with low MU (3, 5, and 7 MU) were performed, and positional accuracy and dose distribution of MLC were analyzed. MLC positional accuracy was calculated from the log-files and the MLC position error, gap size error, MLC leaf speed were calculated and compared with the planned value...
2018: Nihon Hoshasen Gijutsu Gakkai Zasshi
https://www.readbyqxmd.com/read/29925553/analgesic-effect-of-long-acting-somatostatin-receptor-agonist-pasireotide-in-a-patient-with-acromegaly-and-intractable-headaches
#11
Christina M Lovato, Patricia L Kapsner
A 22-year-old woman presented with worsening vision loss and headaches. A diagnosis of acromegaly was confirmed after detection of an invasive pituitary macroadenoma and biochemical testing. Despite two attempts of surgical debulking of the tumour and administration of long-acting octreotide and cabergoline, growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels were uncontrolled. The patient experienced persistent headaches despite surgery, gamma knife radiation and ventriculoperitoneal shunt placement; she was then enrolled in the ACCESS trial (ClinicalTrials...
June 19, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29925537/-pgc-1%C3%AE-repression-and-high-fat-diet-induce-age-related-macular-degeneration-like-phenotypes-in-mice
#12
Meng Zhang, Yi Chu, Joseph Mowery, Brandon Konkel, Susana Galli, Alexander C Theos, Nady Golestaneh
Age-related macular degeneration (AMD) is the major cause of blindness in the elderly in developed countries and its prevalence is increasing with the aging population. AMD initially affects the retinal pigment epithelium (RPE) and gradually leads to secondary photoreceptor degeneration. Recent studies have associated mitochondrial damage with AMD, and we have observed mitochondrial and autophagic dysfunction and repressed peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1α in native RPE from AMD donor eyes and their respective induced pluripotent stem cell-derived RPE (AMD RPE-iPSC-RPE)...
June 20, 2018: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/29925002/an-hsp20-fbxo4-axis-regulates-adipocyte-function-through-modulating-ppar%C3%AE-ubiquitination
#13
Jiangtong Peng, Yutian Li, Xiaohong Wang, Shan Deng, Jenna Holland, Emily Yates, Jing Chen, Haitao Gu, Kobina Essandoh, Xingjiang Mu, Boyu Wang, Robert K McNamara, Tianqing Peng, Anil G Jegga, Tiemin Liu, Takahisa Nakamura, Kai Huang, Diego Perez-Tilve, Guo-Chang Fan
Exposure to cold temperature is well known to upregulate heat shock protein (Hsp) expression and recruit and/or activate brown adipose tissue and beige adipocytes in humans and animals. However, whether and how Hsps regulate adipocyte function for energy homeostatic responses is poorly understood. Here, we demonstrate a critical role of Hsp20 as a negative regulator of adipocyte function. Deletion of Hsp20 enhances non-shivering thermogenesis and suppresses inflammatory responses, leading to improvement of glucose and lipid metabolism under both chow diet and high-fat diet conditions...
June 19, 2018: Cell Reports
https://www.readbyqxmd.com/read/29924913/mir-27b-3p-is-involved-in-doxorubicin-resistance-of-human-anaplastic-thyroid-cancer-cells-via-targeting-ppar%C3%AE
#14
Yuan Xu, Yi-Fan Han, Bing Ye, Yin-Long Zhang, Jian-Da Dong, Shao-Jun Zhu, Jiong Chen
Chemotherapy is one of the most effective forms of cancer treatment. It has been widely used in the treatment of various malignant tumors. In order to investigate molecular mechanisms responsible for the chemoresistance of anaplastic thyroid cancer (ATC), we established the doxorubicin (Dox) resistance of human ATC SW1736 and 8305C cells and named them SW1736/Dox and 8305C/Dox, respectively. We evaluated the expression of various micro-RNAs (miRNAs) between control and Dox-resistant ATC cells and found that the expression of miR-27b-3p was significantly increased in Dox-resistant ATC cells...
June 20, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29924710/auditory-modulation-of-spiking-activity-and-local-field-potentials-in-area-mt-does-not-appear-to-underlie-an-audiovisual-temporal-illusion
#15
Hulusi Kafaligonul, Thomas D Albright, Gene R Stoner
The timing of brief stationary sounds has been shown to alter the perceived speed of visual apparent motion (AM), presumably by altering the perceived timing of the individual frames of the AM stimuli and/or the duration of the inter-stimulus intervals (ISIs) between those frames. To investigate the neural correlates of this "temporal ventriloquism" illusion, we recorded spiking and local field potential (LFP) activity from area MT (the middle temporal area) in awake, fixating macaques. We found that the spiking activity of most MT neurons (but not the LFP) was tuned for the ISI/speed (these parameters co-varied) of our AM stimuli but that auditory timing had no effect on that tuning...
June 20, 2018: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29923555/determination-of-an-accurate-size-distribution-of-nanoparticles-using-particle-tracking-analysis-corrected-for-the-adverse-effect-of-random-brownian-motion
#16
Yusuke Matsuura, Naoko Ouchi, Ayako Nakamura, Haruhisa Kato
The particle tracking analysis (PTA) method has been widely used to determine the size of nanoparticles from their Brownian motion, using the Stokes-Einstein assumption. However, the size distribution obtained by PTA is broader than the true distribution because of the uncertainties in determining the diffusion coefficients, and a correction of such a broadening effect is essential to obtain reliable results. In order to transform the apparent broadened size distribution from the PTA method to the true size distribution, we begin by approximating the true size distribution as a gamma distribution determined by a shape parameter and a scale parameter, and then we perform a hybrid analysis based on the maximum likelihood estimation and Bayesian parameter inference that accounts for the uncertainties in determining the diffusion coefficients...
June 20, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29923503/addition-of-luminescence-process-in-monte-carlo-simulation-to-precisely-estimate-the-light-emitted-from-water-during-proton-and-carbon-ion-irradiation
#17
Takuya Yabe, Makoto Sasano, Yoshiyuki Hirano, Toshiyuki Toshito, Takashi Akagi, Tomohiro Yamashita, Masateru Hayashi, Tetsushi Azuma, Yusuku Sakamoto, Masataka Komori, Seiichi Yamamoto
Although luminescence of water lower in energy than the Cerenkov-light threshold during proton and carbon-ion irradiation has been found, the phenomenon has not yet been implemented for Monte Carlo simulations. The results provided by the simulations lead to misunderstandings of the physical phenomenon in optical imaging of water during proton and carbon-ion irradiation. To solve the problems, as well as to clarify the light production of the luminescence of water, we modified a Monte Carlo simulation code to include the light production from the luminescence of water and compared them with the experimental results of luminescence imaging of water...
June 20, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29923224/in-vitro-and-in-silico-analyses-of-vicia-faba-l-on-peroxisome-proliferator-activated-receptor-gamma
#18
D Sathya Prabhu, V Devi Rajeswari
The agonists of peroxisome proliferator-activated receptor gamma (PPARγ) from natural victual products were used as antidiabetic agents. Faba bean (Vicia faba L.) is a consequential legume that was known to possess potential antidiabetic activity, whose mechanism of action was unknown. The current study was focused to ascertain gene expression of the nuclear receptor PPARγ by Faba bean pod extract in rat cell lines (RINm5F).The real-time polymerase chain reaction analysis demonstrated that Faba bean pod extract in concentrations of 160 µg/mL have shown 4...
June 20, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29923136/risk-assessment-of-high-concentrations-of-molybdenum-in-forage
#19
U Axelson, M Söderström, A Jonsson
Molybdenum is toxic to ruminants when present in high levels in forage, causing physiological copper deficiency. A critical level for ruminants is 3-10 mg Mo kg-1 dry matter. The average Mo level varies considerably between different arable soils, depending mainly on soil parent material. This study investigated the possibility of using various existing sources of geospatial information (geophysical, biogeochemical and soil chemical) to develop a geography-based risk assessment system. Forage samples (n = 173) were collected in 2006-2007...
June 19, 2018: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/29922489/physics-chemistry-and-hirshfeld-surface-analyses-of-gamma-irradiated-thalidomide-to-evaluate-behavior-under-sterilization-doses
#20
Valner A F S N Mussel, Max P Ferreira, Maria B F Marques, Maria I Yoshida, Mariana R Almeida, Bernardo L Rodrigues, Wagner N Mussel
Thalidomide was indicated as a sedative and antiemetic and prescribed for pregnant women. Its tragic teratogenic effects culminated in withdrawal from the market. Since the discovery of its anti-angiogenic and anti-inflammatory actions, thalidomide has been used in the treatment of leprosy and multiple myeloma, which justify studies of its stability. We investigated the effects of irradiation of thalidomide up to 100 kGy (fourfold the usual sterilizing dose for pharmaceutics). The β polymorph of thalidomide was obtained in an isothermal experiment at 270 °C...
June 2018: Journal of Pharmaceutical Analysis
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