keyword
https://read.qxmd.com/read/38493157/the-localization-origin-and-impact-of-platelets-in-the-tumor-microenvironment-are-tumor-type-dependent
#1
JOURNAL ARTICLE
Ophélie Le Chapelain, Soumaya Jadoui, Angèle Gros, Samir Barbaria, Keltouma Benmeziane, Véronique Ollivier, Sébastien Dupont, Mialitiana Solo Nomenjanahary, Sabrina Mavouna, Jasmina Rogozarski, Marie-Anne Mawhin, Giuseppina Caligiuri, Sandrine Delbosc, Françoise Porteu, Bernhard Nieswandt, Pierre H Mangin, Yacine Boulaftali, Benoit Ho-Tin-Noé
BACKGROUND: How platelets interact with and influence the tumor microenvironment (TME) remains poorly characterized. METHODS: We compared the presence and participation of platelets in the TME of two tumors characterized by highly different TME, PyMT AT-3 mammary tumors and B16F1 melanoma. RESULTS: We show that whereas firmly adherent platelets continuously line tumor vessels of both AT-3 and B16F1 tumors, abundant extravascular stromal clusters of platelets from thrombopoietin-independent origin were present only in AT-3 mammary tumors...
March 16, 2024: Journal of Experimental & Clinical Cancer Research: CR
https://read.qxmd.com/read/38493133/blood-based-biomarkers-in-patients-with-non-small-cell-lung-cancer-treated-with-immune-checkpoint-blockade
#2
REVIEW
Yo-Ting Tsai, Jeffrey Schlom, Renee N Donahue
The paradigm of non-small cell lung cancer (NSCLC) treatment has been profoundly influenced by the development of immune checkpoint inhibitors (ICI), but the range of clinical responses observed among patients poses significant challenges. To date, analyses of tumor biopsies are the only parameter used to guide prognosis to ICI therapy. Tumor biopsies, however, are often difficult to obtain and tissue-based biomarkers are limited by intratumoral heterogeneity and temporal variability. In response, there has been a growing emphasis on the development of "liquid biopsy"‒ derived biomarkers, which offer a minimally invasive means to dynamically monitor the immune status of NSCLC patients either before and/or during the course of treatment...
March 16, 2024: Journal of Experimental & Clinical Cancer Research: CR
https://read.qxmd.com/read/38492435/development-of-a-c-met-x-cd137-bispecific-antibody-for-targeted-immune-agonism-in-cancer-immunotherapy
#3
JOURNAL ARTICLE
Hong Zhang, Qun Wang, Sireesha Yalavarthi, Lukas Pekar, Steven Shamnoski, Liufang Hu, Laura Helming, Stefan Zielonka, Chunxiao Xu
BACKGROUND: Targeting the costimulatory receptor CD137 has shown promise as a therapeutic approach for cancer immunotherapy, resulting in anti-tumor efficacy demonstrated in clinical trials. However, the initial CD137 agonistic antibodies, urelumab and utomilumab, faced challenges in clinical trials due to the liver toxicity or lack of efficacy, respectively. Concurrently, c-MET has been identified as a highly expressed tumor-associated antigen (TAA) in various solid and soft tumors. METHODS: In this study, we aimed to develop a bispecific antibody (BsAb) that targets both c-MET and CD137, optimizing the BsAb format and CD137 binder for efficient delivery of the CD137 agonist to the tumor microenvironment (TME)...
March 8, 2024: Cancer Treatment and Research Communications
https://read.qxmd.com/read/38492205/liquid-biopsy-for-breast-cancer-and-other-solid-tumors-a-review-of-recent-advances
#4
JOURNAL ARTICLE
Hirofumi Ohmura, Fumiyasu Hanamura, Yuta Okumura, Yuki Ando, Takaaki Masuda, Koshi Mimori, Koichi Akashi, Eishi Baba
Liquid biopsy using circulating tumor DNA (ctDNA) has been reported to be less invasive and effective for comprehensive genetic analysis of heterogeneous solid tumors, including decision-making for therapeutic strategies, predicting recurrence, and detecting genetic factors related to treatment resistance in various types of cancers. Breast cancer, colorectal cancer, and lung cancer are among the most prevalent malignancies worldwide, and clinical studies of liquid biopsy for these cancers are ongoing. Liquid biopsy has been used as a companion diagnostic tool in clinical settings, and research findings have accumulated, especially in cases of colorectal cancer after curative resection and non-small cell lung cancer (NSCLC) after curative chemoradiotherapy, in which ctDNA detection helps predict eligibility for adjuvant chemotherapy...
March 16, 2024: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://read.qxmd.com/read/38490109/neutrophils-an-emerging-new-therapeutic-platform
#5
REVIEW
Alejandra López-Arredondo, José A Cruz-Cardenas, Jorge A Cázares-Preciado, Nicholas E Timmins, Marion Eg Brunck
Neutrophils possess unique characteristics that render them indispensable to health, and patients with irregular neutrophil counts or functions suffer from increased morbidity and mortality. As neutrophils are short-lived postmitotic cells, genetic aberrations cannot be corrected directly in neutrophils and must be targeted in their progenitors. Neutrophils are increasingly being contemplated for a range of therapeutic applications, including restoration or modulation of immune function and targeting of solid tumors...
March 13, 2024: Current Opinion in Biotechnology
https://read.qxmd.com/read/38488758/the-therapeutic-potential-of-cytokine-induced-killer-in-patients-with-cancer
#6
REVIEW
Sixun Zhong, Yan Zhang, Xiaomin Lu, Vafa Meftahpour
Despite the promising results of immunotherapy, further experiments need to be considered because of several factors ranging from physical barriers to off-tumor adverse effects. It is surprising that adoptive cellular immunotherapy, particularly dendritic cell and cytokine-induced killer (DC-CIK) therapy, is far less emphasized in the treatment of cancer diseases. DC-CIK therapy in cancer patients presents auspicious results with low or no side effects, which should not be overlooked. More interestingly, almost all DC-CIK clinical trials are ongoing in China that highlight the limitations of therapeutic strategies and require large-scale research...
March 2024: Journal of Interferon & Cytokine Research
https://read.qxmd.com/read/38487119/peritoneal-recurrence-of-squamous-cell-carcinoma-in-a-young-woman-after-conization-for-microinvasive-cervical-cancer
#7
Isao Otsuka
Microinvasive squamous cell carcinoma of the cervix develops mainly in young women. As metastases rarely occur, cervical conization to preserve fertility is often performed. We report a case of peritoneal recurrence developed after conization. A 31-year-old nulligravid woman with microinvasive squamous cell carcinoma of the cervix was treated with laser conization. Pathology showed a stromal invasion of <1 mm and a longitudinal spread of 3 mm without lymphovascular space involvement. Forty-seven months after conization, a pelvic examination revealed a firm, immobile mass on the right side of the pelvis...
February 2024: Curēus
https://read.qxmd.com/read/38486092/informing-immunotherapy-with-multi-omics-driven-machine-learning
#8
REVIEW
Yawei Li, Xin Wu, Deyu Fang, Yuan Luo
Progress in sequencing technologies and clinical experiments has revolutionized immunotherapy on solid and hematologic malignancies. However, the benefits of immunotherapy are limited to specific patient subsets, posing challenges for broader application. To improve its effectiveness, identifying biomarkers that can predict patient response is crucial. Machine learning (ML) play a pivotal role in harnessing multi-omic cancer datasets and unlocking new insights into immunotherapy. This review provides an overview of cutting-edge ML models applied in omics data for immunotherapy analysis, including immunotherapy response prediction and immunotherapy-relevant tumor microenvironment identification...
March 14, 2024: NPJ Digital Medicine
https://read.qxmd.com/read/38484040/tumor-microenvironment-activatable-nanoprodrug-system-for-in-situ-fluorescence-imaging-and-therapy-of-liver-cancer
#9
JOURNAL ARTICLE
Can Xie, Yongbo Peng, Zhen Zhang, Kun Luo, Qiaomei Yang, Libin Tan, Liyi Zhou
The development of new imaging and treatment nanoprodrug systems is highly demanded for diagnosis and therapy of liver cancer, a severe disease characterized by a high recurrence rate. Currently, available small molecule drugs are not possible for cancer diagnosis because of the fast diffusion of imaging agents and low efficacy in treatment due to poor water solubility and significant toxic side effects. In this study, we report the development of a tumor microenvironment activatable nanoprodrug system for the diagnosis and treatment of liver cancer...
March 14, 2024: Analytical Chemistry
https://read.qxmd.com/read/38479675/a-comprehensive-performance-evaluation-comparison-and-integration-of-computational-methods-for-detecting-and-estimating-cross-contamination-of-human-samples-in-cancer-next-generation-sequencing-analysis
#10
REVIEW
Huijuan Chen, Bing Wang, Lili Cai, Xiaotian Yang, Yali Hu, Yiran Zhang, Xue Leng, Wen Liu, Dongjie Fan, Beifang Niu, Qiming Zhou
Cross-sample contamination is one of the major issues in next-generation sequencing (NGS)-based molecular assays. This type of contamination, even at very low levels, can significantly impact the results of an analysis, especially in the detection of somatic alterations in tumor samples. Several contamination identification tools have been developed and implemented as a crucial quality-control step in the routine NGS bioinformatic pipeline. However, no study has been published to comprehensively and systematically investigate, evaluate, and compare these computational methods in the cancer NGS analysis...
March 12, 2024: Journal of Biomedical Informatics
https://read.qxmd.com/read/38478334/isolating-cancer-stem-cells-from-solid-tumors
#11
JOURNAL ARTICLE
Vitale Del Vecchio, Marcella La Noce, Virginia Tirino
Over the past 20 years, there has been a lot of interest in the study and investigation of cancer stem cells (CSCs) or tumor-initiating cells (TICs). CSCs are rare, dormant cells and able to self-renew and maintain tumor development and heterogeneity. A new age of basic and clinical cancer research, reclassification of human tumors, and the development of novel therapeutic approaches will undoubtedly result from a better knowledge of CSCs. In order to develop effective and therapeutic strategies to treat cancer, it is crucial to understand the basic characteristics of CSCs, their importance to cancer therapy, and methodologies to isolate, detect, and characterize them...
2024: Methods in Molecular Biology
https://read.qxmd.com/read/38476238/signaling-lymphocytic-activation-molecule-family-receptors-as-potential-immune-therapeutic-targets-in-solid-tumors
#12
REVIEW
Metin Gunes, Steven T Rosen, Idit Shachar, E Gulsen Gunes
Recently, cancer immunotherapy has revolutionized cancer treatment. Various forms of immunotherapy have a manageable safety profile and result in prolongation of overall survival in patients with solid tumors, but only in a proportion of patients. Various factors in the tumor microenvironment play critical roles and may be responsible for this lack of therapeutic response. Signaling lymphocytic activation molecule family (SLAMF) members are increasingly being studied as factors impacting the tumor immune microenvironment...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38476010/aberrant-timp-1-production-in-tumor-associated-fibroblasts-drives-the-selective-benefits-of-nintedanib-in-lung-adenocarcinoma
#13
JOURNAL ARTICLE
Paula Duch, Natalia Díaz-Valdivia, Marta Gabasa, Rafael Ikemori, Marselina Arshakyan, Patricia Fernández-Nogueira, Alejandro Llorente, Cristina Teixido, Josep Ramírez, Javier Pereda, Lourdes Chuliá-Peris, José Marcelo Galbis, Frank Hilberg, Noemí Reguart, Derek C Radisky, Jordi Alcaraz
The fibrotic tumor microenvironment is a pivotal therapeutic target. Nintedanib, a clinically approved multikinase antifibrotic inhibitor, is effective against lung adenocarcinoma (ADC) but not squamous cell carcinoma (SCC). Previous studies have implicated the secretome of tumor-associated fibroblasts (TAFs) in the selective effects of nintedanib in ADC, but the driving factor(s) remained unidentified. Here we examined the role of tissue inhibitor of metalloproteinase-1 (TIMP-1), a tumor-promoting cytokine overproduced in ADC-TAFs...
March 12, 2024: Cancer Science
https://read.qxmd.com/read/38475762/a-multicenter-high-quality-data-registry-for-advanced-proton-therapy-approaches-the-power-registry
#14
JOURNAL ARTICLE
Daniela Alterio, Maria Giulia Vincini, Stefania Volpe, Luca Bergamaschi, Mattia Zaffaroni, Sara Gandini, Giulia Peruzzotti, Federica Cattani, Cristina Garibaldi, Barbara Alicja Jereczek-Fossa, Roberto Orecchia
BACKGROUND: Paucity and low evidence-level data on proton therapy (PT) represent one of the main issues for the establishment of solid indications in the PT setting. Aim of the present registry, the POWER registry, is to provide a tool for systematic, prospective, harmonized, and multidimensional high-quality data collection to promote knowledge in the field of PT with a particular focus on the use of hypofractionation. METHODS: All patients with any type of oncologic disease (benign and malignant disease) eligible for PT at the European Institute of Oncology (IEO), Milan, Italy, will be included in the present registry...
March 12, 2024: BMC Cancer
https://read.qxmd.com/read/38474452/research-progress-in-traditional-applications-phytochemistry-pharmacology-and-safety-evaluation-of-cynomorium-songaricum
#15
REVIEW
Jin Zhang, Xingyi Chen, Lu Han, Biao Ma, Mengting Tian, Changcai Bai, Ye Zhang
Cynomorium songaricum Rupr. (CSR) belongs to the family Cynomoriaceae . It is a perennial succulent parasitic herb with a reddish-brown coloration, predominantly submerged in sand and lacking chlorophyll. Traditionally, it has been used in ethnic medicine to treat various diseases, such as gastric ulcers, indigestion, bowel movements, and improving sexual function. To comprehensively collect CSR data, extensive literature searches were conducted using medical, ecological, and scientific databases such as Google Scholar, PubMed, Science Direct, Web of Science, and China National Knowledge Infrastructure (CNKI)...
February 21, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38473402/monoclonal-antibodies-for-targeted-fluorescence-guided-surgery-a-review-of-applicability-across-multiple-solid-tumors
#16
REVIEW
Stefano Giuliani, Irene Paraboschi, Angus McNair, Myles Smith, Kenneth S Rankin, Daniel S Elson, Vinidh Paleri, Daniel Leff, Graeme Stasiuk, John Anderson
This study aims to review the status of the clinical use of monoclonal antibodies (mAbs) that have completed or are in ongoing clinical trials for targeted fluorescence-guided surgery (T-FGS) for the intraoperative identification of the tumor margins of extra-hematological solid tumors. For each of them, the targeted antigen, the mAb generic/commercial name and format, and clinical indications are presented, together with utility, doses, and the timing of administration. Based on the current scientific evidence in humans, the top three mAbs that could be prepared in a GMP-compliant bank ready to be delivered for surgical purposes are proposed to speed up the translation to the operating room and produce a few readily available "off-the-shelf" injectable fluorescent probes for safer and more effective solid tumor resection...
March 4, 2024: Cancers
https://read.qxmd.com/read/38473383/preventing-and-treating-pain-and-anxiety-during-needle-based-procedures-in-children-with-cancer-in-low-and-middle-income-countries
#17
JOURNAL ARTICLE
Michael J McNeil, Ximena Garcia Quintero, Miriam Gonzalez, Yawen Zheng, Cecilia Ugaz Olivares, Roxana Morales, Erica Boldrini, Débora Rebollo de Campos, Daiane Ferreira, Kamalina Coopasamy, Joliza Caneba, Maria Louisa Padernilla, Stefan Friedrichsdorf, Justin N Baker, Paola Friedrich
Introduction : Children with cancer experience significant pain and anxiety during needle-based procedures. Undertreated pain in children has long-lasting consequences and reduces the efficacy of subsequent analgesic efforts. A validated quality improvement (QI) intervention, known as the "Children's Comfort Promise", includes (1) topical anesthetics, (2) sucrose or breastfeeding for infants, (3) comfort positioning, and (4) distraction techniques, and has been shown to be highly effective in decreasing procedural pain and anxiety in children...
March 1, 2024: Cancers
https://read.qxmd.com/read/38473033/use-of-sensor-array-analysis-to-detect-ovarian-cancer-through-breath-urine-and-blood-a-case-control-study
#18
JOURNAL ARTICLE
Roberto Angioli, Marco Santonico, Giorgio Pennazza, Roberto Montera, Daniela Luvero, Alessandra Gatti, Alessandro Zompanti, Panaiotis Finamore, Raffaele Antonelli Incalzi
Ovarian cancer (OC) is the eighth most common cancer in women. Since screening programs do not exist, it is often diagnosed in advanced stages. Today, the detection of OC is based on clinical examination, transvaginal ultrasound (US), and serum biomarker (Carbohydrate Antigen 125 (CA 125) and Human Epididymis Protein 4 (HE4)) dosage, with a sensitivity of 88% and 95%, respectively, and a specificity of 84% for US and 76% for biomarkers. These methods are clearly not enough, and OC in its early stages is often missed...
March 6, 2024: Diagnostics
https://read.qxmd.com/read/38472567/circulating-tumor-dna-ctdna-and-its-role-in-gynecologic-malignancies
#19
REVIEW
Tali Pomerantz, Rebecca Brooks
Circulating tumor DNA (ctDNA) refers to small fragments of DNA released into the bloodstream by cancer cells. It is obtained through "liquid biopsy;" which most commonly refers to plasma or blood samples, but can be obtained from a number of bodily fluids including ascitic fluid, saliva, and even urine and stool. ctDNA is detected via polymerase chain reaction (PCR) or next-generation sequencing (NGS). The DNA from these samples is analyzed for the detection of point mutations, copy-number alterations, gene fusion, and DNA methylation...
March 12, 2024: Current Treatment Options in Oncology
https://read.qxmd.com/read/38472174/hypoxia-induced-exosomal-circ-znf609-promotes-pre-metastatic-niche-formation-and-cancer-progression-via-mir-150-5p-vegfa-and-hur-zo-1-axes-in-esophageal-squamous-cell-carcinoma
#20
JOURNAL ARTICLE
Yu Mao, Jiahao Wang, Yimin Wang, Zhanzhao Fu, Lixin Dong, Jia Liu
Exosomes derived from cancer are regarded as significant mediators of cancer-host crosstalk. Hypoxia, on the other hand, is one of the essential characteristics of solid tumors. This research set out to discover how circulating exosomes from hypoxic esophageal squamous cell carcinoma (ESCC) contribute to the formation of metastatic niches and distant metastasis. First, we noticed that human umbilical vein endothelial cells (HUVECs) had their tight connections disrupted and the expression of proteins involved in angiogenesis boosted by ESCC hypoxic exosomes...
March 12, 2024: Cell Death Discovery
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