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https://www.readbyqxmd.com/read/29048471/a-new-staging-system-for-cardiac-transthyretin-amyloidosis
#1
Julian D Gillmore, Thibaud Damy, Marianna Fontana, Matthew Hutchinson, Helen J Lachmann, Ana Martinez-Naharro, Candida C Quarta, Tamer Rezk, Carol J Whelan, Esther Gonzalez-Lopez, Thirusha Lane, Janet A Gilbertson, Dorota Rowczenio, Aviva Petrie, Philip N Hawkins
Aims: Cardiac transthyretin (ATTR) amyloidosis is an increasingly recognized, progressive, and fatal cardiomyopathy, the natural history of which remains unclear. We sought to establish and validate a new prognostic staging system applicable to patients with both wild-type ATTR (ATTRwt) and hereditary variant ATTR (ATTRv) amyloid cardiomyopathy. Methods and results: Eight hundred and sixty-nine patients with cardiac ATTR amyloidosis (553 with ATTRwt and 316 with ATTRv) attending the UK National Amyloidosis Centre were stratified into three disease stages at baseline on the basis of cut points in two universally measured biomarkers, N-terminal pro-B-type natriuretic peptide (NT-proBNP) and estimated glomerular filtration rate (eGFR)...
October 18, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29043996/clinical-therapeutic-strategy-of-recombinant-human-brain-natriuretic-peptide-and-dopamine-in-cardiorenal-syndrome-type-4-patients-combined-with-hypotension
#2
Bing Han, Hua Li, Qiaoli Ma
Aim of the present study is to investigate the clinical efficacy of recombinant human brain natriuretic peptide (rhBNP) and dopamine combination treatment in patients with cardiorenal syndrome type 4 (CRS4) combined with hypotension. A total of 160 CRS4 patients admitted to our hospital from July 2010 to December 2014 were recruited, and were randomly divided into two groups, the observational group (n=80) and the control group (n=80). CRS4 patients treated with dopamine were recruited into the control group...
July 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29043986/potential-of-big-data-analytics-in-the-french-in-vitro-diagnostics-market
#3
Nicolas Dubois, Nicolas Garnier, Christophe Meune
The new paradigm of the big data raises many expectations, particularly in the field of health. Curiously, even though medical biology laboratories generate a great amount of data, the opportunities offered by this new field are poorly documented. For better understanding the clinical context of chronical disease follow-up, for leveraging preventive and/or personalized medicine, the contribution of big data analytics seems very promising. It is within this framework that we have explored to use data of a Breton group of laboratories of medical biology to analyze the possible contributions of their exploitation in the improvement of the clinical practices and to anticipate the evolution of pathologies for the benefit of patients...
October 18, 2017: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/29043325/a-fully-integrated-microfluidic-platform-for-highly-sensitive-analysis-of-immunochemical-parameters
#4
Sascha Lutz, Eloisa Lopez-Calle, Pamela Espindola, Christoph Boehm, Thorsten Brueckner, Juergen Spinke, Moritz Marcinowski, Thomas Keller, Armin Tgetgel, Nicolas Herbert, Thomas Fischer, Erik Beiersdorf
We present a novel fully integrated centrifugal microfluidic platform for highly sensitive immunoassays in point-of-care settings. The platform consists of a disposable cartridge containing structures for assay processing, a porous membrane and all dried reagents required for the analysis. Additionally, a blister containing a washing buffer is connected to a new aliquoting structure enabling the serial aliquoting of washing buffer for repetitive bound-free separation steps. The proof-of-concept for two immunoassays is shown in the cartridge with each requiring only 30 μL of whole blood or plasma as the sample material...
October 18, 2017: Analyst
https://www.readbyqxmd.com/read/29035594/total-body-water-dynamics-estimated-with-bioelectrical-impedance-vector-analysis-and-b-type-natriuretic-peptide-after-exposure-to-hypobaric-hypoxia-a-field-study
#5
Giacomo Strapazzon, Matiram Pun, Tomas Dal Cappello, Emily Procter, Piergiorgio Lochner, Hermann Brugger, Antonio Piccoli
Strapazzon, Giacomo, Matiram Pun, Tomas Dal Cappello, Emily Procter, Piergiorgio Lochner, Hermann Brugger, and Antonio Piccoli. Total body water dynamics estimated with bioelectrical impedance vector analysis and B-type natriuretic peptide after exposure to hypobaric hypoxia: A field study. High Alt Med Biol. 18:000-000, 2017.-The relationship between total body water (TBW) dynamics and N-terminal pro-B-type natriuretic peptide (NT-proBNP), a stable metabolite of B-type natriuretic peptide, during acute high altitude exposure is not known...
October 16, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/29035464/galectin-3-reflects-left-atrial-function-being-assessed-by-cardiac-magnetic-resonance-imaging
#6
Seung-Hyun Kim, Michael Behnes, Michele Natale, Sonja Hamed, Julia Hoffmann, Ursula Hoffmann, Johannes Budjan, Siegfried Lang, Martin Borggrefe, Theano Papavassiliu, Thomas Bertsch, Ibrahim Akin
BACKGROUND: This study aims to evaluate the association between galectin-3 and left atrial function (LAF) in patients undergoing cMRI. METHODS: Patients undergoing cMRI were prospectively enrolled. Right ventricular dysfunction (< 50%) was excluded. Blood samples for biomarker measurements of galectin-3 and NT-proBNP were collected at the time of cMRI examination. RESULTS: A total of 84 patients were included. Median LVEF was 59% (IQR 51 - 64%)...
October 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/29034563/heart-failure-study-of-multipoint-pacing-effects-on-ventriculoarterial-coupling-rationale-and-design-of-the-humvee-trial
#7
Christina Chrysohoou, Polychronis Dilaveris, Christos-Konstantinos Antoniou, Ioannis Skiadas, Konstantinos Konstantinou, Konstantinos Gatzoulis, Ioannis Kallikazaros, Dimitrios Tousoulis
Cardiac resynchronization therapy (CRT) is an established therapy for symptomatic heart failure (HF). Unfortunately, many recipients remain nonresponders. Studies have revealed the potential role of multipoint pacing (MPP) in improving response and outcomes. The aim of this study is to compare the effects of MPP against those of standard biventricular pacing (BVP) on (i) ventriculoarterial coupling (VAC) and energy efficiency of the failing heart, (ii) diastolic function, (iii) quality of life, and (iv) NT-proBNP levels and glomerular filtration rate (GFR) during a follow-up of 13 months...
October 15, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/29032136/a-multicenter-randomized-double-blind-placebo-controlled-trial-of-the-efficacy%C3%A2-and-safety-of-the-oral-soluble-guanylate-cyclase-stimulator-the-victoria-trial
#8
REVIEW
Paul W Armstrong, Lothar Roessig, Mahesh J Patel, Kevin J Anstrom, Javed Butler, Adriaan A Voors, Carolyn S P Lam, Piotr Ponikowski, Tracy Temple, Burkert Pieske, Justin Ezekowitz, Adrian F Hernandez, Joerg Koglin, Christopher M O'Connor
This trial sought to evaluate whether vericiguat, a novel oral soluble guanylate cyclase (sGC) stimulator, was superior to placebo, on a background of standard of care, in increasing the time to the first occurrence of the composite endpoints of cardiovascular (CV) death and heart failure (HF) hospitalization in patients with HF with reduced ejection fraction (HFrEF). Deficiency in sGC-derived cyclic guanosine monophosphate (cGMP) causes both myocardial dysfunction and impaired endothelium-dependent vasomotor regulation that includes the myocardial microcirculation...
October 4, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/29028161/effect-of-haemodialysis-and-residual-renal-function-on-serum-levels-of-galectin-3-b-type-natriuretic-peptides-and-cardiac-troponin-t
#9
Matthew A Roberts, Piyush M Srivastava, David L Hare, Francesco L Ierino
AIM: Levels of plasma markers of myocardial fibrosis (galectin-3), stretch (B-type natriuretic peptide (BNP)) and injury (troponin T (TnT)) may be affected by haemodialysis and residual renal function (RRF) in addition to cardiac pathology. We aimed to determine the association of RRF, urine output and haemodialysis itself on clinically important cardiac biomarkers in haemodialysis patients. METHODS: Adult haemodialysis patients underwent venesection pre- and post- haemodialysis followed by echocardiography and inter-dialytic urine collection to calculate RRF (mL/minute/1...
October 13, 2017: Nephrology
https://www.readbyqxmd.com/read/29027324/circulating-microrna-132-levels-improve-risk-prediction-for-heart-failure-hospitalization-in-patients-with-chronic-heart-failure
#10
Serge Masson, Sandor Batkai, Julia Beermann, Christian Bär, Angelika Pfanne, Sabrina Thum, Michela Magnoli, Giovanna Balconi, Gian Luigi Nicolosi, Luigi Tavazzi, Roberto Latini, Thomas Thum
AIMS: Non-coding microRNAs (miRNAs) are critically involved in cardiovascular pathophysiology. Since they are measurable in most body fluids, they have been proposed as circulating biomarkers. We examined the prognostic value of a specific candidate miRNA in a large cohort of patients with chronic heart failure (HF) enrolled in a multicentre clinical trial. METHODS AND RESULTS: Plasma levels of miR-132 were measured using miRNA-specific PCR-based technologies at randomization in 953 patients with chronic, symptomatic HF from the GISSI-Heart Failure trial...
October 12, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29024324/clinical-implications-of-gastrointestinal-symptoms-in-systemic-amyloidosis
#11
T Yen, F W Chen, R M Witteles, M Liedtke, L A Nguyen
BACKGROUND: Gastrointestinal (GI) symptoms in systemic amyloidosis patients are poorly characterized. This purpose of this study is to define the epidemiology and clinical implications of such symptoms. METHODS: This was a retrospective cohort study of 583 amyloid patients seen at a tertiary referral center. Of 96 symptomatic patients, 82 received endoscopic biopsies, subsequently grouped into those with histologic evidence of GI amyloid (biopsy proven) vs without (biopsy absent)...
October 10, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29021435/a-case-of-hyponatremia-with-loss-of-high-signal-intensity-in-the-posterior-pituitary-lobe-on-t1-weighted-magnetic-resonance-imaging
#12
Masayuki Kitagawa, Yoshihiro Yamanaka, Toru Adachi, Junitsu Ito, Kazutoshi Fukase, Ikuro Ohta, Tadashi Katagiri
Herein, we report on an 82-year-old woman who presented with anorexia. The patient had hyponatremia with preserved urinary osmotic pressure. T1-weighted magnetic resonance imaging (MRI) showed a lack of high signal intensity (SI) in the posterior pituitary lobe. Based on the patient's high levels of N-terminal prohormone of brain natriuretic peptide (NT-proBNP), heart failure was suspected. The heart failure may have caused arginine vasopressin (AVP) secretion. The depletion of AVP secretory granules may therefore cause the posterior pituitary gland to disappear on T1-weighted MRI...
October 11, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29021258/age-sex-and-blood-pressure-related-influences-on-reference-values-of-left-atrial-deformation-and-mechanics-from-a-large-scale-asian-population
#13
Jo-Nan Liao, Tze-Fan Chao, Jen-Yuan Kuo, Kuo-Tzu Sung, Jui-Peng Tsai, Chi-In Lo, Yau-Huei Lai, Cheng-Huang Su, Chung-Lieh Hung, Hung-I Yeh, Shih-Ann Chen
BACKGROUND: Left atrial (LA) function is tightly linked to several cardiovascular diseases and confers key prognostic information. Speckle tracking-based deformation as a feasible and sensitive LA mechanical assessment has proven its clinical significance beyond volume measures; however, the reference values remain largely unknown. METHODS AND RESULTS: We studied 4042 participants undergoing annual cardiovascular survey. Among them, 2812 healthy participants (65% men; mean age, 47...
October 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29020337/refining-the-prognostic-impact-of-functional-mitral-regurgitation-in-chronic-heart-failure
#14
Georg Goliasch, Philipp E Bartko, Noemi Pavo, Stephanie Neuhold, Raphael Wurm, Julia Mascherbauer, Irene M Lang, Guido Strunk, Martin Hülsmann
Aims: Significant efforts are currently undertaken to reduce functional mitral regurgitation (FMR) in patients with chronic heart failure in the hope to improve prognosis. We aimed to assess the prognostic impact of FMR in heart failure with reduced ejection fraction (HFrEF) under optimal medical therapy (OMT) and various conditions of HFrEF. We further intended to identify a heart failure phenotype, where FMR is most likely a driving force and not a mere bystander of the disease. Methods and results: We prospectively included 576 consecutive HFrEF patients into our long-term observational study...
July 25, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29018639/managing-heart-failure-at-home-with-point-of-care-diagnostics
#15
Paul R Degregory, Jansen Tapia, Tammy Wong, Jo Villa, Ian Richards, Richard M Crooks
The objective of this paper is development of an inexpensive point-of-care sensor for detecting the primary heart failure marker peptide, NT-proBNP. The device technology is based on an antibody sandwich assay, but with three innovative aspects. First, chemical amplification is carried out via oxidation of silver nanoparticles (NPs) attached to signaling antibodies rather than by enzymatic amplification. The electrochemical method is faster and eliminates the need for long-term storage of enzymes. Second, the antibody sandwich is formed on mobile magnetic beads...
2017: IEEE Journal of Translational Engineering in Health and Medicine
https://www.readbyqxmd.com/read/29018174/prognostic-value-of-n-terminal-pro-b-type-natriuretic-peptide-levels-in-heart-failure-patients-with-and-without-atrial-fibrillation
#16
Søren Lund Kristensen, Pardeep S Jhund, Ulrik M Mogensen, Rasmus Rørth, William T Abraham, Akshay Desai, Kenneth Dickstein, Jean L Rouleau, Michael R Zile, Karl Swedberg, Milton Packer, Scott D Solomon, Lars Køber, John J V McMurray
BACKGROUND: Patients with heart failure (HF) and atrial fibrillation (AF) have higher circulating levels of NT-proBNP (N-terminal pro-B-type natriuretic peptide) than HF patients without AF. There is uncertainty about the prognostic importance of a given concentration of NT-proBNP in HF patients with and without AF. We investigated this question in a large cohort of patients with HF and reduced ejection fraction. METHODS AND RESULTS: We studied 14 737 patients with HF and reduced ejection fraction and a measurement of NT-proBNP at time of screening, enrolled in either the PARADIGM-HF trial (Prospective Comparison of ARNI With ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure) or the ATMOSPHERE trial (Aliskiren Trial to Minimize Outcomes in Patients With Heart Failure), of whom 3575 (24%) had AF on their baseline ECG...
October 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29017565/safety-and-efficacy-of-qishen-granules-in-patients-with-chronic-heart-failure-study-protocol-for-a-randomized-controlled-trial
#17
Jinping Wang, Jun Shi, Jiawei Wei, Juan Wang, Kuo Gao, Xueli Li, Jianxin Chen, Shaojing Li, Huihui Zhao, Wei Wang
BACKGROUND: Chronic heart failure (CHF), the final stage of various cardiovascular diseases, is a major public health problem resulting in significant hospitalization rates, mortality, and huge health care costs despite advances in the treatment and management of heart failure and heart failure-related risk factors. Qishen granules (QSG), a Chinese herbal formula, is widely used by traditional Chinese medicine (TCM) practitioners to treat CHF. Several animal experimental studies have showed that QSG can significantly relieve the heart failure symptoms in CHF rat models...
October 10, 2017: Trials
https://www.readbyqxmd.com/read/28990414/biomarkers-of-endothelial-renal-and-platelet-dysfunction-in-stage-5-chronic-kidney-disease-hemodialysis-patients-with-heart-failure
#18
Ryan McMillan, Leonidas Skiadopoulos, Debra Hoppensteadt, Nil Guler, Vinod Bansal, Ravipresenna Parasuraman, Jawed Fareed
The aim of this study was to determine the role of endothelial, renal, and inflammatory biomarkers in the pathogenesis of heart failure (HF) in patients with stage 5 chronic kidney disease (CKD5) undergoing maintenance hemodialysis (HD). Plasma levels of biomarkers-kidney injury molecule 1 (KIM-1), N-terminal pro brain natriuretic peptide (NT-proBNP), glycated hemoglobin, neutrophil gelatinase-associated lipocalin, interleukin-18,platelet-derived growth factor, platelet factor 4 (PF4), 25-OH vitamin D, parathyroid hormone (PTH), endothelin, and endocan-were measured in CKD5-HD patients at the Loyola University Ambulatory Dialysis facility...
January 1, 2017: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/28988688/plasma-n-terminal-pro-brain-natriuretic-peptide-concentrations-before-and-after-pericardiocentesis-in-dogs-with-cardiac-tamponade-secondary-to-spontaneous-pericardial-effusion
#19
R D Baumwart, A S Hanzlicek, S D Lyon, P M Lee
OBJECTIVE: To determine if concentrations of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) are increased in dogs with cardiac tamponade and if there is a significant increase in plasma NT-proBNP after pericardiocentesis. ANIMALS: Ten client-owned dogs with spontaneous cardiac tamponade. METHODS: Prospective clinical study. Cardiac tamponade was suspected from physical examination and confirmed with echocardiography. Blood was collected and plasma NT-proBNP concentrations were measured before and 30-60 min following pericardiocentesis and resolution of cardiac tamponade...
October 4, 2017: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
https://www.readbyqxmd.com/read/28985746/porcine-model-of-progressive-cardiac-hypertrophy-and-fibrosis-with-secondary-postcapillary-pulmonary-hypertension
#20
Mariann Gyöngyösi, Noemi Pavo, Dominika Lukovic, Katrin Zlabinger, Andreas Spannbauer, Denise Traxler, Georg Goliasch, Ljubica Mandic, Jutta Bergler-Klein, Alfred Gugerell, Andras Jakab, Zsuzsanna Szankai, Levente Toth, Rita Garamvölgyi, Gerald Maurer, Frederic Jaisser, Faiez Zannad, Thomas Thum, Sándor Bátkai, Johannes Winkler
BACKGROUND: Meaningful translational large animal models for cardiac diseases are indispensable for studying disease mechanisms, development of novel therapeutic strategies, and evaluation of potential drugs. METHODS: For induction of heart failure, cardiac hypertrophy and fibrosis, a bare metal stent was implanted in the descending aorta of growing pigs (n = 7), inducing pressure stress on the left ventricle (group HYPI). The constant stent size in growing pigs resulted in antegrade partial obstruction of the aortic flow with a gradual increase in afterload...
October 6, 2017: Journal of Translational Medicine
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