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NT-proBNP

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https://www.readbyqxmd.com/read/28721832/biomarkers-associated-with-bleeding-risk-in-the-setting-of-atrial-fibrillation
#1
Skevos Sideris, Stefanos Archontakis, George Latsios, George Lazaros, Konstantinos Toutouzas, Eleftherios Tsiamis, Manolis Vavuranakis, Charalampos Vlachopoulos, Konstantinos Gatzoulis, Konstantinos Tsioufis, Dimitris Tousoulis
Background Prevention of thromboembolic disease, mainly stroke, with oral anticoagulants remains a major therapeutic goal in patients with atrial fibrillation. Unfortunately, despite the high efficacy, anticoagulant therapy is associated with a significant risk of, frequently catastrophic, hemorrhagic complications. Among different clinical and laboratory parameters related to an increased risk of bleeding, several biological markers have been recognized and various risk scores for bleeding have been developed...
July 18, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28719009/diagnosis-of-chronic-heart-failure-by-the-soluble-suppression-of-tumorigenicity-2-and-n-terminal-pro-brain-natriuretic-peptide
#2
Xiao-Ling Jin, Ning Huang, Hui Shang, Ming-Cheng Zhou, Yi Hong, Wen-Zheng Cai, Jie Huang
OBJECTIVE: Our study was to explore the roles between serum soluble suppression of tumorigenicity 2 (sST2) and N-terminal pro-brain natriuretic peptide (NT-proBNP) while evaluating ventricular function to properly diagnose chronic heart failure (CHF). METHODS: In total, 197 CHF patients were recruited and classified into ventricular function's II, III, and IV groups, and 106 healthy people into normal control group. To detect concentrations of Sst2 and NT-proBNP, ELISA and electro-chemiluminescence immuno assay were implemented...
July 18, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28718187/brain-natriuretic-propeptide-as-an-early-marker-of-bronchopulmonary-dysplasia-or-death-in-the-preterm-newborn
#3
Alicia Montaner, Raquel Pinillos, Zenaida Galve, Hector Boix, Carmen Ruiz de la Cuesta, Lorenzo Jimenez, Pilar Samper, Segundo Rite
Aim To investigate whether increased brain natriuretic propeptide (NT-proBNP) levels at 48 to 72 h of life are associated with the development of bronchopulmonary dysplasia (BPD) or death in premature neonates. Methods A retrospective study was performed in neonates born before 32 weeks' gestation or with birth weight below 1500 grams, in whom NT-proBNP determination and echocardiography were performed at 48 to 72 h of life. Associations between NT-proBNP levels and the combined outcome BPD or death were analyzed using multivariate logistic regression analysis...
July 2017: Klinische Pädiatrie
https://www.readbyqxmd.com/read/28716979/blood-biomarkers-for-the-early-diagnosis-of-stroke-the-stroke-chip-study
#4
Alejandro Bustamante, Elena López-Cancio, Sara Pich, Anna Penalba, Dolors Giralt, Teresa García-Berrocoso, Carles Ferrer-Costa, Teresa Gasull, María Hernández-Pérez, Mónica Millan, Marta Rubiera, Pedro Cardona, Luis Cano, Helena Quesada, Mikel Terceño, Yolanda Silva, Mar Castellanos, Moisés Garces, Silvia Reverté, Xavier Ustrell, Rafael Marés, Joan Josep Baiges, Joaquín Serena, Francisco Rubio, Eduardo Salas, Antoni Dávalos, Joan Montaner
BACKGROUND AND PURPOSE: Stroke diagnosis could be challenging in the acute phase. We aimed to develop a blood-based diagnostic tool to differentiate between real strokes and stroke mimics and between ischemic and hemorrhagic strokes in the hyperacute phase. METHODS: The Stroke-Chip was a prospective, observational, multicenter study, conducted at 6 Stroke Centers in Catalonia. Consecutive patients with suspected stroke were enrolled within the first 6 hours after symptom onset, and blood samples were drawn immediately after admission...
July 17, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28712855/plasma-high-sensitivity-troponin-t-predicts-end-stage-renal-disease-and-cardiovascular-and-all-cause-mortality-in-patients-with-type-1-diabetes-and-diabetic-nephropathy
#5
Julie Galsgaard, Frederik Persson, Tine Willum Hansen, Anders Jorsal, Lise Tarnow, Hans-Henrik Parving, Peter Rossing
High-sensitivity troponin T (hsTnT) is a marker of cardiovascular disease (CVD) and in type 2 diabetes also a marker of renal events, but has not been evaluated in type 1 diabetics. We therefore reviewed a type 1 diabetes cohort of 442 without and 458 with diabetic nephropathy. Baseline samples were analyzed for hsTnT levels. Cox regression analyses assessed predictive value in relation to the development of end-stage renal disease (ESRD) in 99 patients, all-cause mortality in 178, and CVD events in 134 after up to 12 years of follow-up...
July 13, 2017: Kidney International
https://www.readbyqxmd.com/read/28705266/a-new-method-for-blood-nt-probnp-determination-based-on-a-near-infrared-point-of-care-testing-device-with-high-sensitivity-and-wide-scope
#6
Xiao Guang Zhang, Yao Gen Shu, Ju Gao, Xuan Wang, Li Peng Liu, Meng Wang, Yu Xi Cao, Yi Zeng
OBJECTIVE: To develop a rapid, highly sensitive, and quantitative method for the detection of NT-proBNP levels based on a near-infrared point-of-care diagnostic (POCT) device with wide scope. METHODS: The lateral flow assay (LFA) strip of NT-proBNP was first prepared to achieve rapid detection. Then, the antibody pairs for NT-proBNP were screened and labeled with the near-infrared fluorescent dye Dylight-800. The capture antibody was fixed on a nitrocellulose membrane by a scribing device...
June 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/28704807/high-sensitivity-troponin-t-and-nt-probnp-kinetics-in-breast-cancer-chemotherapy
#7
Pooja Advani, Jonathan Hoyne, Alvaro Moreno-Aspita, Marcia Dubin, Shelly Brock, Caroline Harlow, Saranya Chumsri, Thomas Suter, Joseph L Blackshear
BACKGROUND/AIMS: Doxorubicin (DOX) and trastuzumab (TRA) are associated with cardiac dysfunction. METHOD: High-sensitivity troponin T (hs-TnT) and brain natriuretic peptide attached to the amino acid N-terminal fragment in the prohormone (NT-proBNP) were measured before and on days +1, +2, +3, and +7 during cycles 1 and 2 of therapy with DOX or TRA in breast cancer patients. RESULTS: Five of eleven DOX-treated women, compared with 2/11 TRA-treated women, had undetectable baseline hs-TnT...
July 14, 2017: Chemotherapy
https://www.readbyqxmd.com/read/28704534/short-term-variation-in-ntprobnp-after-lifestyle-intervention-in-severe-obesity
#8
Debora Fedele, Virginia Bicchiega, Alessandro Collo, Federica Barutta, Erika Pistone, Gabriella Gruden, Graziella Bruno
AIM: Natriuretic peptides are not only involved in cardiovascular adaption to various conditions, but also in metabolic diseases. We performed this study to assess the effect of a very short time of lifestyle inpatient intervention on NTproBNP values in normotensive subjects with severe obesity and normal cardiac function. METHODS: We recruited 14 consecutive obese normotensive subjects with normal cardiac function who were aged 30 years and more and were referred to inpatient rehabilitation in an academic clinic over a two months period...
2017: PloS One
https://www.readbyqxmd.com/read/28701708/beyond-the-debye-length-in-high-ionic-strength-solution-direct-protein-detection-with-field-effect-transistors-fets-in-human-serum
#9
Chia-Ho Chu, Indu Sarangadharan, Abiral Regmi, Yen-Wen Chen, Chen-Pin Hsu, Wen-Hsin Chang, Geng-Yen Lee, Jen-Inn Chyi, Chih-Chen Chen, Shu-Chu Shiesh, Gwo-Bin Lee, Yu-Lin Wang
In this study, a new type of field-effect transistor (FET)-based biosensor is demonstrated to be able to overcome the problem of severe charge-screening effect caused by high ionic strength in solution and detect proteins in physiological environment. Antibody or aptamer-immobilized AlGaN/GaN high electron mobility transistors (HEMTs) are used to directly detect proteins, including HIV-1 RT, CEA, NT-proBNP and CRP, in 1X PBS (with 1%BSA) or human sera. The samples do not need any dilution or washing process to reduce the ionic strength...
July 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28700781/efficacy-and-safety-of-spironolactone-in-acute-heart-failure-the-athena-hf-randomized-clinical-trial
#10
Javed Butler, Kevin J Anstrom, G Michael Felker, Michael M Givertz, Andreas P Kalogeropoulos, Marvin A Konstam, Douglas L Mann, Kenneth B Margulies, Steven E McNulty, Robert J Mentz, Margaret M Redfield, W H Wilson Tang, David J Whellan, Monica Shah, Patrice Desvigne-Nickens, Adrian F Hernandez, Eugene Braunwald
Importance: Persistent congestion is associated with worse outcomes in acute heart failure (AHF). Mineralocorticoid receptor antagonists administered at high doses may relieve congestion, overcome diuretic resistance, and mitigate the effects of adverse neurohormonal activation in AHF. Objective: To assess the effect of high-dose spironolactone and usual care on N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels compared with usual care alone. Design, Setting, and Participants: This double-blind and placebo (or low-dose)-controlled randomized clinical trial was conducted in 22 US acute care hospitals among patients with AHF who were previously receiving no or low-dose (12...
July 12, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28696825/androgen-status-in-non-diabetic-elderly-men-with-heart-failure
#11
Goran Loncar, Biljana Bozic, Aleksandar N Neskovic, Natasa Cvetinovic, Mitja Lainscak, Nenad Prodanovic, Hans-Dirk Dungen, Stephan von Haehling, Zoran Radojicic, Tobias Trippel, Biljana Putnikovic, Natasa Markovic-Nikolic, Vera Popovic
PURPOSE: We aimed at evaluating androgen status (serum testosterone [TT] and estimated free testosterone [eFT]) and its determinants in non-diabetic elderly men with heart failure (HF). Additionally, we investigated its associations with body composition and long-term survival. METHODS: Seventy three non-diabetic men with HF and 20 healthy men aged over 55 years were studied. Echocardiography, 6-min walk test, grip strength, body composition measurement by DEXA method were performed...
July 11, 2017: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/28690311/predictors-of-long-term-mortality-and-frequent-re-hospitalization-in-patients-with-acute-decompensated-heart-failure-and-kidney-dysfunction-treated-with-renin-angiotensin-system-blockers
#12
Canan Baydemir, Dilek Ural, Kurtuluş Karaüzüm, Sibel Balci, Onur Argan, Irem Karaüzüm, Güliz Kozdağ, Ayşen A Ağır
BACKGROUND Assessment of risk for all-cause mortality and re-hospitalization is an important task during discharge of acute heart failure (AHF) patients, as they warrant different management strategies. Treatment with optimal medical therapy may change predictors for these 2 end-points in AHF patients with renal dysfunction. The aim of this study was to evaluate the predictors for long-term outcome in AHF patients with kidney dysfunction who were discharged on optimal medical therapy. MATERIAL AND METHODS The study was conducted retrospectively...
July 10, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28685712/effects-of-traditional-chinese-medicine-shensong-yangxin-capsules-on-heart-rhythm-and-function-in-congestive-heart-failure-patients-with-frequent-ventricular-premature-complexes-a-randomized-double-blind-multicenter-clinical-trial
#13
Xi Wang, Dan Hu, Song Dang, He Huang, Cong-Xin Huang, Ming-Jie Yuan, Yan-Hong Tang, Qing-Shan Zheng, Fang Yin, Shu Zhang, Bo-Li Zhang, Run-Lin Gao
BACKGROUND: Pharmacological therapy for congestive heart failure (CHF) with ventricular arrhythmia is limited. In the study, our aim was to evaluate the effects of Chinese traditional medicine Shensong Yangxin capsules (SSYX) on heart rhythm and function in CHF patients with frequent ventricular premature complexes (VPCs). METHODS: This double-blind, placebo-controlled, multicenter study randomized 465 CHF patients with frequent VPCs to the SSYX (n = 232) and placebo groups (n = 233) for 12 weeks of treatment...
July 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28684396/cardiac-stress-and-inflammatory-markers-as-predictors-of-heart-failure-in-patients-with-type-2-diabetes-the-advance-trial
#14
Toshiaki Ohkuma, Min Jun, Mark Woodward, Sophia Zoungas, Mark E Cooper, Diederick E Grobbee, Pavel Hamet, Giuseppe Mancia, Bryan Williams, Paul Welsh, Naveed Sattar, Jonathan E Shaw, Kazem Rahimi, John Chalmers
OBJECTIVE: This study examined the individual and combined effect of N-terminal pro-B-type natriuretic peptide (NT-proBNP), high-sensitivity cardiac troponin T (hs-cTnT), interleukin-6 (IL-6), and hs-CRP on the prediction of heart failure incidence or progression in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS: A nested case-cohort study was conducted in 3,098 participants with type 2 diabetes in the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE) trial...
July 6, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28683166/multi-biomarker-analysis-in-patients-with-acute-myocardial-infarction
#15
Christiana Schernthaner, Michael Lichtenauer, Bernhard Wernly, Vera Paar, Rudin Pistulli, Ilonka Rohm, Christian Jung, Hans-Reiner Figulla, Attila Yilmaz, Janne Cadamuro, Elisabeth Haschke-Becher, John Pernow, P Christian Schulze, Uta C Hoppe, Daniel Kretzschmar
BACKGROUND: Novel biomarkers representing different pathobiological pathways and their role in patients with acute myocardial infarction (AMI) were studied. METHODS: We retrospectively analyzed serum levels of soluble suppression of tumorigenicity (sST2), growth-differentiation factor-15 (GDF-15), soluble urokinase plasminogen activator receptor (suPAR), heart-type fatty acid-binding protein (H-FABP) and plasma fetuin A in blood of patients with AMI (STEMI, n=61; NSTEMI, n=57) compared to controls with excluded coronary artery disease (n=76)...
July 6, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28681124/toe-brachial-index-as-a-predictor-of-cardiovascular-disease-and-all-cause-mortality-in-people-with-type-2-diabetes-and-microalbuminuria
#16
Emilie H Zobel, Bernt Johan von Scholten, Henrik Reinhard, Frederik Persson, Tine W Hansen, Hans-Henrik Parving, Peter K Jacobsen, Peter Rossing
AIMS/HYPOTHESIS: The study aimed to evaluate toe-brachial index (TBI) and ankle-brachial index (ABI) as determinants of incident cardiovascular disease (CVD) and all-cause mortality in people with type 2 diabetes and microalbuminuria. METHODS: This was a prospective study including 200 participants. Unadjusted and adjusted (traditional risk factors and additional inclusion of N-terminal pro-brain natriuretic peptide [NT-proBNP] and coronary artery calcification) Cox regression models were performed...
July 5, 2017: Diabetologia
https://www.readbyqxmd.com/read/28680124/refining-long-term-prediction-of-cardiovascular-risk-in-diabetes-the-vildia-score
#17
Georg Goliasch, Günther Silbernagel, Marcus E Kleber, Tanja B Grammer, Stefan Pilz, Andreas Tomaschitz, Philipp E Bartko, Gerald Maurer, Wolfgang Koenig, Alexander Niessner, Winfried März
Cardiovascular risk assessment in patients with diabetes relies on traditional risk factors. However, numerous novel biomarkers have been found to be independent predictors of cardiovascular disease, which might significantly improve risk prediction in diabetic patients. We aimed to improve prediction of cardiovascular risk in diabetic patients by investigating 135 evolving biomarkers. Based on selected biomarkers a clinically applicable prediction algorithm for long-term cardiovascular mortality was designed...
July 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28679686/long-term-mortality-and-prehospital-tirofiban-treatment-in-patients-with-st-elevation-myocardial-infarction
#18
Enrico Fabris, Sinem Kilic, Dirk A A M Schellings, Jurrien M Ten Berg, Mark W Kennedy, K Gerts van Houwelingen, Evangelos Giannitsis, Evelien Kolkman, Jan Paul Ottervanger, Christian Hamm, Arnoud W J Van't Hof
OBJECTIVE: We undertook a subgroup analysis of the On-TIME 2 (Ongoing Tirofiban In Myocardial infarction Evaluation 2), a placebo-controlled, double-blind, randomised trial, in order to evaluate the association between N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels and long-term (5 years) mortality and to investigate the effect of prehospital tirofiban administration on mortality in relation to NT-proBNP levels. METHODS: A total of 984 patients with ST elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI) were randomised to either in ambulance tirofiban or placebo...
July 5, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28669333/biomarkers-in-stable-coronary-artery-disease
#19
Jonas Rusnak, Christian Fastner, Michael Behnes, Kambis Mashayekhi, Martin Borggrefe, Ibrahim Akin
BACKGROUND: Coronary artery disease (CAD) is the most common reason for death in the western hemisphere. Therefore, a well-functioning risk-management has been established over the past decades with uprising interest in 'novel' biomarkers to predict adverse coronary events and detect patients with subclinical CAD. This review will focus on selected biomarkers belonging to the family of inflammatory markers (fibrinogen or hs-CRP) or to the family of lipid-associated markers (Lipoprotein associated PA2 or Lipoprotein a) and others are direct organ-specific biomarkers (hs-troponin, Cystatin C or NT-proBNP)...
June 30, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28667454/effects-of-cardiac-resynchronization-therapy-on-right-ventricular-function-during-rest-and-exercise-as-assessed-by-radionuclide-angiography-and-on-nt-probnp-levels
#20
Cinzia Valzania, Mauro Biffi, Rachele Bonfiglioli, Francesco Fallani, Cristian Martignani, Igor Diemberger, Matteo Ziacchi, Jessica Frisoni, Luciana Tomasi, Stefano Fanti, Claudio Rapezzi, Giuseppe Boriani
AIM: We carried out this study to investigate mid-term effects of cardiac resynchronization therapy (CRT) on right ventricular (RV) function and neurohormonal response, expressed by N-terminal pro-brain natriuretic peptide (NT-proBNP), in heart failure patients stratified by baseline RV ejection fraction (RVEF). METHODS AND RESULTS: Thirty-six patients with nonischemic dilated cardiomyopathy underwent technetium-99m radionuclide angiography with bicycle exercise immediately after CRT implantation (during spontaneous rhythm and after CRT activation) and 3 months later...
June 30, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
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