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Masashi Sakuma, Shigeru Toyoda, Takuo Arikawa, Yota Koyabu, Toru Kato, Taichi Adachi, Hideaki Suwa, Jun-Ichi Narita, Koetsu Anraku, Kimihiko Ishimura, Fumitake Yamauchi, Yasunori Sato, Teruo Inoue
BACKGROUND: Hyperuricemia has a close relationship with cardiovascular diseases including heart failure. However, it is controversial whether xanthine oxidase inhibition has benefits for patients with chronic heart failure. We designed the Effect of Xanthine Oxidase Inhibitor in Chronic Heart Failure Patients Complicated with Hyperuricemia study (Excited-UA study) to compare the beneficial effects between a novel xanthine oxidoreductase inhibitor, topiroxostat, and a conventional agent, allopurinol, in patients with chronic heart failure and hyperuricemia...
June 18, 2018: Clinical and Experimental Nephrology
Malgorzata Kobusiak-Prokopowicz, Justyna Krzysztofik, Konrad Kaaz, Beata Jolda-Mydlowska, Andrzej Mysiak
The aim of the study was to assess MMP-2 (matrix metalloproteinase-2) and TIMP-2 (tissue inhibitor of metalloproteinase-2) serum levels in patients with diverse types of heart failure (HF) and chronic kidney disease (CKD). 101 patients with chronic HF were enrolled. Each patient has assessed the serum levels of MMP-2, TIMP-2, and NT-proBNP. Patients were initially classified into 2 groups based on their LVEF. 43 patients were classified into the HFREF group (HF with Reduced Ejection Fraction) and 58 characterized as HFPEF (HF with Preserved Ejection Fraction)...
2018: Open Medicine (Warsaw, Poland)
Suk-Won Choi, Seongwoo Han, Wan Joo Shim, Dong-Ju Choi, Yong-Jin Kim, Byung-Su Yoo, Kyung-Kuk Hwang, Hui Kyung Jeon, Mi-Seung Shin, Kyu-Hyung Ryu
Background: We aimed to evaluate effect of heart rate (HR) reduction on left ventricular reverse remodeling (LVRR) in Korean patients with heart failure with reduced ejection fraction (HFrEF). Methods: Ambulatory patients with HFrEF, who had paired echocardiograms, N-terminal prohormone brain natriuretic peptide (NT-proBNP), and global assessment score (GAS) at baseline and 6-month (n = 157), were followed up on preset treatment schedule with bisoprolol. Results: The LVRR occurred in 49 patients (32%) at 6-month...
June 18, 2018: Journal of Korean Medical Science
Pedro Zuzarte, Gustavo Scola, Angela Duong, Kari Kostiw, Maria L Figueira, Atilio Costa-Vitali
Depression and anxiety are prevalent in patients with heart failure (HF). Reduced ejection fraction (EF) and increased N-terminal-prohormone B-type natriuretic peptide (NT-proBNP) have been shown to be independently associated with depressive symptoms and may therefore increase HF disease progression and mortality. This study evaluated whether NT-proBNP mediated the impact of reduced EF on depressive and anxiety symptoms in patients with HF. Participants (n = 124) were patients with a diagnosis of chronic HF enrolled in the Heart Failure Disease Management Program at Health Sciences North...
June 9, 2018: Journal of Psychiatric Research
M Yldau van der Ende, M Abdullah Said, Dirk J van Veldhuisen, N Verweij, Pim van der Harst
Heart failure (HF) is a complex clinical syndrome resulting from structural or functional impairments of ventricular filling or ejection of blood. HF has a poor prognosis and the burden to society remains tremendous. The unfulfilled expectation is that expanding our knowledge of the genetic architecture of HF will help to quickly advance the quality of risk assessment, diagnoses, and treatment. To date, Genome Wide Association Studies (GWAS) of HF have led to disappointing results with only limited progress in our understanding and tempering the earlier expectations...
April 18, 2018: Cardiovascular Research
Jeffrey Netto, Boris Jansen-Winkeln, René Thieme, Jan Eckardt, Yoon Ju Bae, Anja Willenberg, Sabine Huppert, Orestes Lyros, Stefan Niebisch, Friederike Allecke, Nicole Kreuser, Jürgen Kratzsch, Thorsten Kaiser, Uta Ceglarek, Joachim Thiery, Ines Gockel
INTRODUCTION: Any surgical procedure develops a stress situation for the patient, which can modulate the individual outcome. At present, there is only limited information about stress response in colorectal resections by laparoscopic compared to conventional surgery. Therefore, our objectives were the feasibility and the investigation of stress biomarkers including copeptin and steroid hormones before, during and after colorectal surgery. METHODS: Eleven patients underwent minimally invasive and ten patients conventionally open colorectal surgery...
June 17, 2018: Acta Chirurgica Belgica
Roberto Bolli, Joshua M Hare, Timothy D Henry, Carrie G Lenneman, Keith L March, Kathy Miller, Carl J Pepine, Emerson C Perin, Jay H Traverse, James T Willerson, Phillip C Yang, Adrian P Gee, João A Lima, Lem Moyé, Rachel W Vojvodic, Shelly L Sayre, Judy Bettencourt, Michelle Cohen, Ray F Ebert, Robert D Simari
OBJECTIVES: SENECA (StEm cell iNjECtion in cAncer survivors) is a phase I, randomized, double-blind, placebo-controlled study to evaluate the safety and feasibility of delivering allogeneic mesenchymal stromal cells (allo-MSCs) transendocardially in subjects with anthracycline-induced cardiomyopathy (AIC). BACKGROUND: AIC is an incurable and often fatal syndrome, with a prognosis worse than that of ischemic or nonischemic cardiomyopathy. Recently, cell therapy with MSCs has emerged as a promising new approach to repair damaged myocardium...
July 2018: American Heart Journal
János Tomcsányi, Miklós Somlói, Béla Bózsik, Tamás Frész, Erzsébet Nagy
INTRODUCTION: The determination of natriuretic peptide levels in patients hospitalized for suspected acute heart failure is important for the confirmation of the diagnosis and for the prognosis. Changes in natriuretic peptide levels in response to therapy have a strong prognostic value. AIM: To decide whether repeated natriuretic peptide measurements for acute heart failure show changes that could influence the diagnosis and/or the prognosis. METHOD: Prospective data collection was carried out of N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels on admission and within 12 hours in patients hospitalized for acute heart failure...
June 2018: Orvosi Hetilap
Anna Smukowska-Gorynia, Justyna Marcinkowska, Ewa Chmara, Katarzyna Malaczynska-Rajpold, Sylwia Slawek-Szmyt, Artur Cieslewicz, Magdalena Janus, Aleksander Araszkiewicz, Stanislaw Jankiewicz, Anna Komosa, Anna Olasinska-Wisniewska, Iga Tomaszewska, Tatiana Mularek-Kubzdela
BACKGROUND: Upregulation of the immune system is regarded to play an important role in the etiopathobiology of pulmonary arterial hypertension (PAH) and inoperable chronic thromboembolic pulmonary hypertension (CTEPH). To the best of our knowledge, neopterin (NP) has never been investigated in patients with PAH and CTEPH. OBJECTIVES: The aim of the study was to evaluate the concentration of NP in blood in order to examine its impact on outcome and relationship with disease severity in that population...
June 15, 2018: Respiration; International Review of Thoracic Diseases
Eva Steinmann, Hans-Peter Brunner-La Rocca, Micha T Maeder, Beat A Kaufmann, Matthias Pfisterer, Peter Rickenbacher
BACKGROUND: Whether the clinical presentation and in particular prevalence of symptoms and signs of heart failure (HF) is different in elderly versus younger patients and in those with reduced (HFrEF) versus preserved (HFpEF) left ventricular ejection fraction (LVEF) is a matter of ongoing debate. AIMS: To compare detailed clinical characteristics of these important subgroups and to develop a prediction rule for the differentiation of HFpEF and HFrEF based on clinical parameters...
June 13, 2018: European Journal of Internal Medicine
Liang Xu, Yanchun Chen, Yanni Ji, Song Yang
Factors influencing N-terminal pro-brain natriuretic peptide (NT-proBNP) level in heart failure patients with different cardiac functions were identified to explore the correlations with prognosis. Eighty heart failure patients with different cardiac functions treated in Yixing People's Hospital from January 2016 to June 2017 were selected, and divided into two groups (group with cardiac function in class II and below and group with cardiac function in class III and above), according to the cardiac function classification established by New York Heart Association (NYHA)...
June 2018: Experimental and Therapeutic Medicine
Jae Yun Jung, Eun Mi Ham, Hyuksool Kwon, Young Ho Kwak, Do Kyun Kim, Jin Hee Lee, Jin Hee Jung
BACKGROUND: Coronary artery dilatation (CAD) is a great concern with Kawasaki disease (KD). This study aimed to investigate the relationship between serum N-terminal pro-brain natriuretic peptide (NT-proBNP) levels and CAD in patients with the hyperacute phase (≤4 days of fever) of KD. METHODS: Serum NT-proBNP levels were compared between patients with and those without CAD, who underwent transthoracic echocardiography (TTE) within 24 h of the hyperacute phase of KD in the pediatric emergency department (PED)...
June 8, 2018: American Journal of Emergency Medicine
Leona Wall, Annika Mohr, Florenza Lüder Ripoli, Nayeli Schulze, Camila Duarte Penter, StephanOscar Hungerbuehler, Jan-Peter Bach, Karin Lucas, Ingo Nolte
Exercise intolerance is the first symptom of heart disease. Yet an objective and standardised method in canine cardiology to assess exercise capacity in a clinical setting is lacking. In contrast, exercise testing is a powerful diagnostic tool in humans, providing valuable information on prognosis and impact of therapeutic intervention. To investigate whether an exercise test reveals differences between dogs with early stage mitral regurgitation (MR) and dogs without cardiac disease, 12 healthy beagles (healthy group, HG) and 12 dogs with presymptomatic MR (CHIEF B1 / B2, patient group, PG) underwent a six-stage submaximal exercise test (ET) on a motorised treadmill...
2018: PloS One
Gang Li, Ying Song, Yun-Da Li, Ling-Jun Jie, Wei-Yin Wu, Jing-Zhou Li, Qiuwang Zhang, Yan Wang
AIM: To explore circulating miRNA-302 family members for acute heart failure (AHF) diagnosis. METHODS: Three groups of subjects, in other words, AHF patients, AHF free patients and healthy controls were recruited. Circulating levels of miR-302 family members were measured and analyzed for AHF diagnosis. RESULTS: Plasma miR-302s except miR-302f were significantly elevated in AHF patients. MiR-302b-3p had the highest area under curve value of 0...
June 14, 2018: Biomarkers in Medicine
M Zubair Israr, Liam M Heaney, Leong L Ng, Toru Suzuki
BACKGROUND: B-type natriuretic peptide (BNP) is known to be a risk marker following acute myocardial infarction (MI). More recently, truncated molecular forms of the BNP molecule have been identified, with the association of these forms and outcome in acute MI not known. The present study investigated their use as risk stratifying biomarkers of this condition. METHODS: BNP molecular forms (BNP 5-32, BNP 4-32 and BNP 3-32) were measured in plasma from 1078 acute MI patients using immunocapture followed by MALDI-ToF-mass spectrometry...
June 2018: American Heart Journal
Seung-Hoon Pi, Sung Mok Kim, Jin-Oh Choi, Eun Kyoung Kim, Sung-A Chang, Yeon Hyeon Choe, Sang-Chol Lee, Eun-Seok Jeon
BACKGROUND: It has been reported that left ventricular (LV) myocardial strain and late gadolinium enhancement (LGE) on cardiovascular magnetic resonance (CMR) imaging have prognostic value in patients with heart failure (HF). However, previous studies included patients with various systolic functions. This study aimed to investigate the prognostic value of LV myocardial strain and LGE on CMR imaging in patients with idiopathic dilated cardiomyopathy (DCM) with reduced ejection fraction (EF < 40%)...
June 14, 2018: Journal of Cardiovascular Magnetic Resonance
Jelena Kornej, Petra Büttner, Philipp Sommer, Nikolaos Dagres, Borislav Dinov, Katja Schumacher, Andreas Bollmann, Gerhard Hindricks
Aims: Low voltage areas (LVAs) represent advanced remodelling processes in left atrium in patients with atrial fibrillation (AF) and are associated with higher rates of arrhythmia recurrences. However, the prediction of LVA based on clinical parameters is understudied. Recently, we introduced APPLE score to predict rhythm outcomes after catheter ablation. The aim of this study was to analyse (i) LVA prediction using APPLE score and (ii) differences in biomarker profiles according to APPLE score in AF patients...
June 8, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Toralph Ruge, Axel C Carlsson, Erik Ingelsson, Ulf Risérus, Johan Sundström, Anders Larsson, Lars Lind, Johan Ärnlöv
OBJECTIVE: Circulating levels of endostatin are elevated in many underlying conditions leading to heart failure such as hypertension, diabetes, chronic kidney disease and ischemic heart disease. Yet, the association between endostatin and the incidence of heart failure has not been reported previously in the community. DESIGN: We investigated the longitudinal association between serum endostatin levels and incident heart failure in two community-based cohorts of elderly: Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS, n = 966; mean age 70 years, 51% women, 81 events, mean follow-up 10 years) and Uppsala Longitudinal Study of Adult Men (ULSAM, n = 747 men; mean age 78 years, 98 heart failure events, mean follow-up 8 years)...
June 12, 2018: Scandinavian Cardiovascular Journal: SCJ
Abdul-Quddus Mohammed, Ranshaka Auckle, Hai-Ling Li, Si-Ling Xu, Lu Liu, Dong-Dong Zhao, Wen-Liang Che
BACKGROUND: Pegylated interferon (pegIFN) in combination with ribavirin (RBV) has successfully improved the rate of sustained virological response (SVR) in chronic hepatitis C virus (HCV) infected individuals, which reduces the progression of the chronic liver disease. However, the influence of combination therapy (pegIFN/RBV) on cardiac function has yielded ambiguous results. The present study aimed to evaluate the effects of combination therapy with pegIFN/RBV on cardiac function of HCV-infected individuals with SVR...
June 2018: American Journal of the Medical Sciences
Michihiro Satoh, Takahisa Murakami, Kei Asayama, Takuo Hirose, Masahiro Kikuya, Ryusuke Inoue, Megumi Tsubota-Utsugi, Keiko Murakami, Ayako Matsuda, Azusa Hara, Taku Obara, Ryo Kawasaki, Kyoko Nomura, Hirohito Metoki, Koichi Node, Yutaka Imai, Takayoshi Ohkubo
BACKGROUND: N-terminal pro-B-type natriuretic peptide (NT-proBNP) has been used for risk stratification in heart failure or acute coronary syndrome, but the beyond 5-year predictive value of NT-proBNP for stroke remains an unsettled issue in Asian patients. The aim of the present study was to clarify this point.Methods and Results:We followed 1,198 participants (33.4% men; mean age, 60.5±11.1 years old) in the Japanese general population for a median of 13.0 years. A first stroke occurred in 93 participants...
June 9, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
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