keyword
https://read.qxmd.com/read/38494757/laboratory-evaluation-of-a-rapid-diagnostic-test-for-dairy-mastitis
#21
JOURNAL ARTICLE
David C Speksnijder, Hendrika C Verduijn, Sharon van Haren, Tomas Ussing, Tine van Werven
Rapid diagnostic tests that differentiate between Gram positive, Gram negative and the absence of aerobic bacteria in milk samples from dairy cows with clinical mastitis can support antimicrobial treatment decisions and contribute to a more prudent use of antimicrobials in the dairy industry. The objective of this study was to evaluate the test characteristics of the novel rapid BACT mastitis test in discriminating causes of clinical mastitis under laboratory conditions. Test outcomes of 155 milk samples from clinical mastitis cases were incubated for 14-16 h in the BACT test and compared to results of bacteriological culture...
March 18, 2024: Journal of Dairy Research
https://read.qxmd.com/read/38494571/evaluating-the-safety-and-efficacy-of-sodium-glucose-co-transporter%C3%A2-2-inhibitors-in-subjects-with-prediabetes-a-protocol-for-a-randomized-controlled-trial
#22
JOURNAL ARTICLE
Xiaxuan Zhu, Li Xia, Deshan Yin, Jin Yang, Rui Wei
INTRODUCTION: Prediabetes is a state of subclinical glycemic impairment, bridging normal glucose tolerance and diabetes. Globally, over 30% of individuals exhibit prediabetic conditions, with a significant proportion progressing to diabetes. Prediabetes augments risks of various diseases including cardiovascular and kidney disease. While interventions like lifestyle changes have shown promise in diabetes prevention, their long-term sustainability is challenging. Alternative pharmacological treatments, such as acarbose and metformin, have demonstrated efficacy in certain populations...
March 18, 2024: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://read.qxmd.com/read/38494549/the-yield-of-routine-laboratory-examination-in-osteoporosis-evaluation-in-primary-care
#23
JOURNAL ARTICLE
Thomas Merlijn, Karin M A Swart, Christy Niemeijer, Henriëtte E van der Horst, Coen J Netelenbos, Petra J M Elders
UNLABELLED: This study evaluated the yield of routine laboratory examination in a large population of older women in primary care. The prevalence of laboratory abnormalities was low and the clinical consequences in follow-up were limited. There was a weak association of laboratory abnormalities with osteoporosis but no association with vertebral fractures and recent fractures. PURPOSE: Most osteoporosis guidelines advice routine laboratory examination. We have investigated the yield of laboratory examinations in facture risk evaluation of elderly women in primary care...
March 18, 2024: Osteoporosis International
https://read.qxmd.com/read/38494511/chromosomal-microarray-testing-yield-in-829-cases-of-microcephaly-a-clinical-characteristics-based-analysis-for-prenatal-and-postnatal-cases
#24
JOURNAL ARTICLE
Rivka Sukenik-Halevy, Nir Mevorach, Lina Basel-Salmon, Reut Tomashov Matar, Sarit Kahana, Kochav Klein, Ifaat Agmon-Fishman, Michal Levy, Idit Maya
INTRODUCTION: Microcephaly, characterized by abnormal head growth, can often serve as an initial indicator of congenital, genetic, or acquired disorders. In this study, we sought to evaluate the effectiveness of chromosomal microarray (CMA) testing in detecting abnormalities in both prenatal and postnatal cases of microcephaly. MATERIALS AND METHODS: CMA Testing: We conducted CMA testing on 87 prenatally-detected microcephaly cases and 742 postnatal cases at a single laboratory...
March 18, 2024: Archives of Gynecology and Obstetrics
https://read.qxmd.com/read/38494381/asynchronous-consult-report-generation-for-pharmacogenomic-clinical-support-time-and-motion
#25
JOURNAL ARTICLE
David R Bright, Donald Klepser, Anna Langerveld
As pharmacogenomic (PGx) testing becomes more commonplace in clinical practice, appropriate application of laboratory data to all relevant medications becomes necessary to maximize PGx value. However, many clinicians lack PGx knowledge and confidence, so prescribers may appreciate clinical support when applying PGx data to a patient's entire medication list. Pharmacists routinely provide PGx consult support, and asynchronous written consults may improve logistical simplicity, but specific process steps and time expectations are less settled...
March 8, 2024: Research in Social & Administrative Pharmacy: RSAP
https://read.qxmd.com/read/38494290/optimizing-the-diagnostic-performance-of-neural-antibody-testing-for-paraneoplastic-and-autoimmune-encephalitis-in-clinical-practice
#26
JOURNAL ARTICLE
Adrian Budhram, Eoin P Flanagan
The detection of neural antibodies in patients with paraneoplastic and autoimmune encephalitis has majorly advanced the diagnosis and management of neural antibody-associated diseases. Although testing for these antibodies has historically been restricted to specialized centers, assay commercialization has made this testing available to clinical chemistry laboratories worldwide. This improved test accessibility has led to reduced turnaround time and expedited diagnosis, which are beneficial to patient care...
2024: Handbook of Clinical Neurology
https://read.qxmd.com/read/38494079/dna-reference-reagents-for-genotyping-rh-variants
#27
JOURNAL ARTICLE
Emilia Sippert, Evgeniya Volkova, Meagan Rippee-Brooks, Gregory A Denomme, Willy A Flegel, Christine Lee, Richardae Araojo, Orieji Illoh, Zhugong Liu, Maria Rios
Patients who carry RH blood group variants may develop Rh alloantibodies requiring matched red cell transfusions. Serologic reagents for Rh variants often fail to specifically identify variant Rh antigens and are in limited supply. Therefore, red cell genotyping assays are essential for managing transfusions in patients with clinically relevant Rh variants. Well-characterized DNA reference reagents are needed to ensure quality and accuracy of the molecular tests. Eight lyophilized DNA reference reagents, representing 21 polymorphisms in RHD and RHCE, were produced from an existing repository of immortalized B-lymphoblastoid cell lines at CBER/U...
March 15, 2024: Journal of Molecular Diagnostics: JMD
https://read.qxmd.com/read/38494078/evaluation-of-pre-analytical-variables-for-hpv-primary-screening-from-self-collected-vaginal-swabs
#28
JOURNAL ARTICLE
Michelle Qi, Anissa R Naranjo, Abigail J Duque, Thomas S Lorey, Jeffrey M Schapiro, Betty J Suh-Burgmann, Michael Rummel, Stephen J Salipante, Nicolas Wentzensen, Dina N Greene
HPV primary screening is an effective approach to assessing cervical cancer risk. Self-collected vaginal swabs have shown promise to expand testing access, but there are limited data defining analytical performance criteria necessary for adoption of self-collected specimens, especially for those occurring outside the clinic where the swab remains dry during transport. Here, we evaluated the performance of self-collected vaginal swabs for HPV detection using the Roche Cobas 6800. There was insignificant variability between swabs self-collected by the same individual (n=15 participants collecting 5 swabs/participant), measured by amplification of HPV and human β-globin control DNA...
March 15, 2024: Journal of Molecular Diagnostics: JMD
https://read.qxmd.com/read/38493966/achieving-specified-laxity-in-a-non-cruciate-total-knee-a-laboratory-design-study
#29
JOURNAL ARTICLE
P S Walker, D Hennessy, J Perez, F Rahman, G Zapata, J Bosco
BACKGROUND: Non-cruciate total knee arthroplasty designs, including ultracongruent, medially congruent, and medial pivot, are gaining increasing attention in total knee arthroplasty surgery. However there is no consensus for the bearing surface design, whether there should be different medial, lateral, anterior and posterior laxities, or whether the medial side should be a medial pivot. This study proposes the criterion of reproducing the laxity of the anatomic knee, defined as the displacements and rotations of the femur on the tibia in the loaded knee when shear and torque are applied...
March 15, 2024: Journal of Arthroplasty
https://read.qxmd.com/read/38493945/external-quality-assurance-in-the-era-of-standardization
#30
REVIEW
Theodorsson Elvar, Meijer Piet, Badrick Tony
Metrology in clinical chemistry aims to ensure the equivalence of measurement results from different in-vitro diagnostic measurement devices (IVD MD) for use in healthcare. The metrological traceability of measurement results to higher-order references is the cornerstone to achieving equivalent results. However, other fundamentals are also needed, including the commutability of reference materials and external quality assessment (EQA) materials for monitoring the equivalence of measurement results at the end-user level...
March 15, 2024: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://read.qxmd.com/read/38493740/tuning-mono-divalent-cation-water-composition-by-the-capacitive-ion-exchange-mechanism
#31
JOURNAL ARTICLE
Julio J Lado, Enrique García-Quismondo, Alba Fombona-Pascual, Andreas Mavrandonakis, Carlos de la Cruz, Freddy E Oropeza, Victor A de la Peña O'Shea, Louis C P M de Smet, Jesús Palma
Soil salinization poses a significant challenge to agricultural activities. To address this, the agricultural industry seeks an irrigation water solution that reduces both ionic conductivity and sodium adsorption rate (SAR), thereby diminishing the risks of soil sodification and fostering sustainable crop production. Capacitive deionization (CDI) is an attractive electrochemical technology to advance this search. Recently, a one-dimensional transient CDI model unveiled a capacitive ion-exchange mechanism presenting the potential to adjust the treated water composition by modifying monovalent and divalent cation concentrations, thereby influencing the SAR index...
March 13, 2024: Water Research
https://read.qxmd.com/read/38493614/case-report-of-mondor-disease-in-a-49-year-old-albanian-woman
#32
Zamira Shabani, Arketa Pllumi Guli
INTRODUCTION AND IMPORTANCE: Mondor Disease is superficial thrombophlebitis mostly located in the thoracic-abdominal wall, mid-upper arm, and penis. The disease can affect all people over 30 years old regardless of race, ethnicity but affects women more than men. The importance of this study case consists on being the first reported case of Mondor Disease in Albania. CASE PRESENTATION: In this study, a case of superficial thrombophlebitis affecting the thoraco-epigastric veins in the right chest wall is reported...
March 15, 2024: International Journal of Surgery Case Reports
https://read.qxmd.com/read/38493378/designing-an-implementable-clinical-prediction-model-for-near-term-mortality-and-long-term-survival-in-patients-on-maintenance-hemodialysis
#33
JOURNAL ARTICLE
Benjamin A Goldstein, Chun Xu, Jonathan Wilson, Ricardo Henao, Patti L Ephraim, Daniel E Weiner, Tariq Shafi, Julia J Scialla
RATIONALE & OBJECTIVE: The life expectancy of patients treated with maintenance hemodialysis (MHD) is heterogeneous. Knowledge of life-expectancy may focus care decisions on near-term versus long-term goals. The current tools are limited and focus on near-term mortality. Here, we develop and assess potential utility for predicting near-term mortality and long-term survival on MHD. STUDY DESIGN: Predictive modeling study. SETTING & PARTICIPANTS: 42,351 patients contributing 997,381 patient months over 11 years, abstracted from the electronic health record (EHR) system of midsize, nonprofit dialysis providers...
February 21, 2024: American Journal of Kidney Diseases
https://read.qxmd.com/read/38493375/coronavirus-disease-2019-infections-among-emergency-health-care-personnel-impact-on-delivery-of-united-states-emergency-medical-care-2020
#34
JOURNAL ARTICLE
Kurt D Weber, William Mower, Anusha Krishnadasan, Nicholas M Mohr, Juan Carlos Montoy, Robert M Rodriguez, Philip A Giordano, Patrick Ten Eyck, Karisa K Harland, Kelli Wallace, Lawrence Clifford McDonald, Preeta K Kutty, Elisabeth M Hesse, David A Talan
STUDY OBJECTIVE: In the early months of the coronavirus disease 2019 (COVID-19) pandemic and before vaccine availability, there were concerns that infected emergency department (ED) health care personnel could present a threat to the delivery of emergency medical care. We examined how the pandemic affected staffing levels and whether COVID-19 positive staff were potentially infectious at work in a cohort of US ED health care personnel in 2020. METHODS: The COVID-19 Evaluation of Risks in Emergency Departments (Project COVERED) project was a multicenter prospective cohort study of US ED health care personnel conducted from May to December 2020...
March 16, 2024: Annals of Emergency Medicine
https://read.qxmd.com/read/38493322/noninvasive-biomarkers-for-lupus-nephritis
#35
JOURNAL ARTICLE
Ting Liu, Yun-Long Yang, Yan Zhou, Yong-Mei Jiang
Lupus nephritis (LN) is one of the most severe clinical manifestations of systemic lupus erythematosus (SLE). Notably, the clinical manifestations of LN are not always consistent with the histopathological findings. Therefore, the diagnosis and activity monitoring of this disease are challenging and largely depend on invasive renal biopsy. Renal biopsy has side effects and is associated with the risk of bleeding and infection. There is a growing interest in the development of novel noninvasive biomarkers for LN...
March 17, 2024: Laboratory Medicine
https://read.qxmd.com/read/38493321/nr3c2-microdeletions-an-underrecognized-cause-of-pseudohypoaldosteronism-type-1a-a-case-report-and-literature-review
#36
JOURNAL ARTICLE
Bobby L Boyanton, Yuri A Zarate, Brannon G Broadfoot, Thomas Kelly, Brendan D Crawford
OBJECTIVES: Pseudohypoaldosteronism type 1A (PHA1A) is caused by haploinsufficiency of the mineralocorticoid receptor (MR). Heterozygous small insertions/deletions, transitions, and/or transversions within NR3C2 comprise the majority (85%-90%) of pathogenic copy number variants. Structural chromosomal abnormalities, contiguous gene deletion syndromes, and microdeletions are infrequent. We describe a neonate with PHA1A due to a novel NR3C2 microdeletion involving exons 1-2. METHODS: Literature review identified 39 individuals with PHA1A due to NR3C2 microdeletions...
March 16, 2024: Laboratory Medicine
https://read.qxmd.com/read/38493297/differential-feeding-on-ornamental-plants-by-duponchelia-fovealis-lepidoptera-crambidae-larvae
#37
JOURNAL ARTICLE
Sophia M Copeman, Steven D Frank
Duponchelia fovealis (Zeller) (Lepidoptera: Crambidae) is a polyphagous pest that feeds on a variety of ornamental and crop plants. At least 47 plant families have been identified as hosts for D. fovealis in literature based on empirical data and observations. This list is surely incomplete based on the broad feeding habits of D. fovealis. We sought to expand the list of known D. fovealis host plants and to identify species that may be less preferred or not fed upon by D. fovealis. We used laboratory feeding assays to measure D...
March 16, 2024: Environmental Entomology
https://read.qxmd.com/read/38492561/efficacy-and-safety-of-dupilumab-in-the-treatment-of-kimura-s-disease
#38
JOURNAL ARTICLE
Y L Liu, Y T Ran, Y F Zhang, X T Peng, Y M Xia, H L Yan
BACKGROUND: Kimura's disease (KD) is a rare chronic inflammatory condition characterized by nodules and lymphadenopathy in the head and neck region, exhibiting type II inflammation. Dupilumab is commonly used against type II inflammation. AIM: To evaluate the efficacy and safety of dupilumab in KD patients. DESIGN: The real-world study was conducted in a hospital in China. METHODS: Six male patients with a mean age of 24...
March 16, 2024: QJM: Monthly Journal of the Association of Physicians
https://read.qxmd.com/read/38492491/pertussis-outbreak-in-children-hospitalized-in-rabat-morocco
#39
JOURNAL ARTICLE
Redouane Mammar Bennai, Amal Zouaki, Ghizlane El Amin, Abdeljalil Rahani, Jalila Zirar, Myriam Seffar, Karim Soully, Chafik Mahraoui, Hakima Kabbaj
INTRODUCTION: Cyclical pertussis epidemics primarily affect young infants. This study aims to estimate pertussis prevalence during the ongoing 2023 outbreak at our institution, focusing on affected age groups and clinical presentations. MATERIEL AND METHODS: This retrospective study includes patients admitted to Rabat University Hospital Center from 1st January 2021 to 30th June 2023. Symptomatic patients underwent Multiplex Respiratory Panel PCR testing for respiratory infections...
February 20, 2024: Diagnostic Microbiology and Infectious Disease
https://read.qxmd.com/read/38492489/polymerase-chain-reaction-negative-cryptococcal-meningitis
#40
Kyle T O'Meara, June L Chan, Stacey Ceron, John C Lam
A 61-year-old male with subacute headache was found to have cryptococcal meningitis despite a negative BioFire FilmArray meningitis/encephalitis panel. This case underscores the importance of liberal cryptococcal antigen testing, and that a negative FilmArray panel is inadequate in excluding cryptococcal meningitis, particularly in a HIV-negative host.
March 8, 2024: Diagnostic Microbiology and Infectious Disease
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