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https://www.readbyqxmd.com/read/29679923/testing-a-motivational-model-of-delivery-modality-and-incentives-on-participation-in-a-brief-alcohol-intervention
#1
Clayton Neighbors, Lindsey M Rodriguez, Lorra Garey, Mary M Tomkins
OBJECTIVES: The current research evaluated delivery modality and incentive as factors affecting recruitment into a personalized normative feedback (PNF) alcohol intervention for heavy drinking college students. We also evaluated whether these factors were differentially associated with participation based on relevance of the intervention (via participants' drinking levels). METHOD: College students aged 18-26 who endorsed at least one heavy drinking episode and one alcohol-related consequence in the past month (N = 2059; 59...
March 28, 2018: Addictive Behaviors
https://www.readbyqxmd.com/read/29679869/characterization-of-adsorption-and-desorption-of-lawn-herbicide-siduron-in-heavy-metal-contaminated-soils
#2
Rong Jiang, Meie Wang, Weiping Chen
Siduron is a widely used herbicide in urban lawn and has been frequently detected in urban and suburban surface water. However, characteristics of its environmental behavior in soil are seldom reported. The combined pollution of heavy metals, especially for Cu, Pb, Cd, Zn and siduron would be common because of the widely existence of heavy metal pollution in urban soils. In this study, four soils with similar physicochemical properties but different levels of preexisting heavy metals were selected to investigate the adsorption and successive desorption of siduron using batch experiments...
April 9, 2018: Chemosphere
https://www.readbyqxmd.com/read/29679593/experimental-and-field-investigatio-n-of-non-biting-flies-as-potential-mechanical-vectors-of-echinococcus-granulosus-eggs
#3
Sahel Hemmati, Abbas Aghaei Afshar, Mohammad Ali Mohammadi, Ali Afgar, Saeid Nasibi, Majid Fasihi Harandi
Synanthropic fly species can be potential mechanical vectors of many infectious agents. The potential of the flies to carry Echinococcus granulosus eggs is not fully documented. The purpose of the present study was to determine the possible role of non-biting flies to carry taeniid eggs. A total of 210 flies were collected from seven selected sites in areas of Kerman city, southeastern Iran from November 2016 to May 2017. Adult flies were live-caught using sweeping nets. Flies were placed individually in small glass bottles and transported to the laboratory...
April 18, 2018: Experimental Parasitology
https://www.readbyqxmd.com/read/29679555/mass-spectrometric-measurement-of-urinary-kynurenine-to-tryptophan-ratio-in-children-with-and-without-urinary-tract-infection
#4
Melanie L Yarbrough, Kelleigh E Briden, John V Mitsios, Annette L Weindel, Cindy M Terrill, David A Hunstad, Dennis J Dietzen
BACKGROUND: Indoleamine-2,3-dioxygenase (IDO) catalyzes the first step of tryptophan (Trp) catabolism, yielding kynurenine (Kyn) metabolites. The kynurenine-to-tryptophan (K/T) ratio is used as a surrogate for biological IDO enzyme activity. IDO expression is increased during Escherichia coli urinary tract infection (UTI). Thus, our objective was to develop a method for measurement of Kyn/Trp ratio in human blood and urine and evaluate its use as a biomarker of UTI. METHODS: A mass spectrometric method was developed to measure Trp and Kyn in serum and urine specimens...
April 18, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29679554/reference-materials-for-molecular-diagnostics-current-achievements-and-future-strategies
#5
REVIEW
Rongrong Jing, Huimin Wang, Shaoqing Ju, Ming Cui
BACKGROUND: Molecular diagnoses have become more widespread in many areas of laboratory medicine where qualitative or quantitative approaches are used to detect nucleic acids. The increasing number of assay methods and the targets for molecular diagnostics contribute to variability in the test results among clinical laboratories. Thus, reference materials (RMs) are required to enhance the comparability of results. METHODS: This review focuses on the definition of RMs as well as the production and characteristics of higher order RMs from different organizations and their future strategies...
April 18, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29679478/randomized-controlled-study-of-bleselumab-askp1240-pharmacokinetics-and-safety-in-patients-with-moderate-to-severe-plaque-psoriasis
#6
Mysore S Anil Kumar, Kim Papp, Ryo Tainaka, Udaya Valluri, Xuegong Wang, Tong Zhu, Christian Schwabe
This study evaluated pharmacokinetics (PK), efficacy, safety, and tolerability of bleselumab - a fully-human anti-CD40 monoclonal recombinant IgG4. Patients with moderate-to-severe psoriasis were randomized on Day 1 to receive bleselumab or placebo on Days 1, 15, and 29 in a dose-escalation of bleselumab 0.1, 0.3, 1.0, or 3.0mg/kg. The safety-analysis set (SAF) and full-analysis set (FAS) included all patients who received bleselumab or placebo, and the PK-analysis set (PKAS) included patients in the SAF with ≥1 quantifiable serum bleselumab concentration...
April 21, 2018: Biopharmaceutics & Drug Disposition
https://www.readbyqxmd.com/read/29678843/analytical-and-workflow-evaluation-of-the-aries-sample-to-result-molecular-assay-for-clostridium-difficile
#7
Steven K Lawson, David Chung, Shubhagata Das, Jeremy Friesen, Susan Sefers, Sherry Dunbar, Jonathan E Schmitz
We evaluated the analytical and workflow characteristics of the ARIES Clostridium difficile assay, a recently developed qPCR-based test for toxigenic C. difficile ARIES was compared to the illumigene C. difficile assay, a commonly employed, loop-mediated amplification technique with similar sample-to-result capabilities. Following illumigene analysis, 122 positive and 164 negative stool specimens were banked for subsequent ARIES testing. The analytical agreement between the platforms was high: 93.4% positive agreement (89...
March 2018: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/29678821/individual-differences-in-torpor-expression-in-adult-mice-are-related-to-relative-birth-weight
#8
Goro A Kato, Shinsuke H Sakamoto, Takeshi Eto, Yoshinobu Okubo, Akio Shinohara, Tetsuo Morita, Chihiro Koshimoto
Daily torpor is a physiological adaptation in small mammals and birds, characterised by drastic reductions in metabolism and body temperature. Energy-constraining conditions, such as cold and starvation, are known to cause the expression of daily torpor. However, the reason for high degrees of inter- and intra- individual variation in torpor expression (TE) in similar situations is not clear. As littermates of altricial animals are exposed to an uneven allocation of maternal resources from conception to weaning, we tested whether early nutritional experiences have long-term effects on TE in adults...
April 20, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29678705/hypophysitis-due-to-paranasal-sinusitis-a-neurosurgical-perspective-from-the-developing-world
#9
El Faith Bashir El Malik, Branavan Manoranjan, Olufemi Ajani, Ahmed Zidan
BACKGROUND: and Importance: Sinusitis is a common clinical condition but sphenoid sinusitis is a less common form and even rarer is hypophysitis as a complication of the latter. Clinically, hypophysitis may mimic a pituitary neoplasm in presenting with mass effect and pituitary hormone dysfunction. CLINICAL PRESENTATION: We present five cases of sinusitis-related hypophysitis treated at the Royal Care International Hospital in Khartoum, Sudan. Clinical symptoms at presentation included: headache, fever, ptosis, ophthalmoplegia and history of sinusitis with running nose (nasal discharge)...
April 17, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29678599/increasing-water-intake-influences-hunger-and-food-preference-but-does-not-reliably-suppress-energy-intake-in-adults
#10
Naomi J McKay, Ilona V Belous, Jennifer L Temple
Increasing water intake is often purported to reduce energy intake, and is recommended as a weight loss strategy. The few experimental studies that have been conducted to verify these claims have examined the impact of a single pre-load of water before a meal. Although correlational data indicate a relationship between hydration, energy intake, and weight status, there is very little experimental research in this area. The current studies examined the hypothesis that elevated hydration, through increased water intake, would suppress energy intake...
April 17, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29678568/likelihood-of-pregnancy-after-the-transfer-of-embryos-derived-from-follicle-aspiration-and-in-vitro-embryo-production-sessions-with-different-relative-efficiencies
#11
Luiz Fernando Feres, Luiz Gustavo Bruno Siqueira, Miller Pereira Palhao, Lívia Loiola Dos Santos, Felipe Zandonadi Brandao, Joao Henrique Moreira Viana
The aim of the present study was to evaluate the likelihood of pregnancy of in vitro-produced (IVP) embryos from batches with distinct relative efficiencies. Data were retrospectively analyzed from 605 transvaginal ultrasonic-guided follicle aspiration sessions (OPU) followed by in vitro embryo production (IVEP) and 2456 fresh embryo transfers (ET), performed between 2008 and 2012 in individuals of the Gir (dairy Bos indicus) breed. The OPU and IVEP were performed using standard procedures by a single group of technicians at the same laboratory facility...
April 15, 2018: Animal Reproduction Science
https://www.readbyqxmd.com/read/29678532/feasibility-and-benefit-of-incorporating-a-multimedia-cadaver-laboratory-training-program-into-a-didactics-curriculum-for-junior-and-senior-surgical-residents
#12
Erika Simmerman, Andrew Simmerman, Randi Lassiter, Ray King, Ben Ham, Bao-Ling Adam, Colville Ferdinand, Steven Holsten
OBJECTIVE: As operative experience in general surgery decreases and work hour limitations increase there is less exposure of surgical residents to advanced vascular and trauma exposures. Many institutions have demonstrated benefits of cadaver laboratory courses. We have incorporated a multimedia cadaver laboratory course into our general surgery residency didactics curriculum with the objective to demonstrate a benefit of the program as well as the feasibility of incorporation. STUDY DESIGN: This is a prospective study at a tertiary care institution including general surgery residents within our residency program...
April 17, 2018: Journal of Surgical Education
https://www.readbyqxmd.com/read/29678483/maxillofacial-brown-tumours-series-of-5-cases
#13
F Antin, D Bakhos, F Jegoux, M Merkouza, L Laccourreye
OBJECTIVES: Brown tumours are benign bone tumours secondary to hyperparathyroidism. The authors describe the various clinical features, diagnostic methods and treatment modalities for maxillofacial brown tumours. MATERIAL AND METHODS: This multicentre retrospective study comprised 5 patients (four women and one man, between the ages of 29 and 70 years) with one or several maxillofacial brown tumours observed over a 16-year period from January 2000 to December 2016...
April 17, 2018: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/29678480/gram-negative-anaerobe-susceptibility-testing-in-clinical-isolates-using-sensititre-and-etest-methods
#14
C Hughes, C Ashhurst-Smith, J K Ferguson
Gram negative anaerobic organisms are important pathogens in a range of clinical infections, and susceptibility testing is not commonly performed in the microbiology laboratory. We performed anaerobic susceptibility testing on 70 clinically relevant Gram negative anaerobes isolated from routine cultures in a busy diagnostic laboratory which were identified by MALDI-TOF mass spectrometry (MALDI-TOF MS). The susceptibility testing was performed by two methods: Sensititre trays (ThermoFisher Scientific) against 15 different antibiotics, and Etests (bioMérieux) against five clinically relevant antibiotics (metronidazole, piperacillin-tazobactam, amoxicillin-clavulanate, meropenem and clindamycin)...
April 17, 2018: Pathology
https://www.readbyqxmd.com/read/29678479/hit-or-miss-a-comprehensive-contemporary-investigation-of-laboratory-tests-for-heparin-induced-thrombocytopenia
#15
Emmanuel J Favaloro, Georgia McCaughan, Soma Mohammed, Kun Kan Edwin Lau, Rosalie Gemmell, Lauren Cavanaugh, Dea Donikian, Mayuko Kondo, Timothy Brighton, Leonardo Pasalic
Heparin induced thrombocytopenia (HIT) is a rare but potentially fatal complication of heparin therapy, which in a proportion of patients causes platelet activation and thrombosis. Initial clinical assessment of the likelihood of HIT is facilitated by laboratory testing to confirm or exclude HIT. This prospective investigation was performed over an 18-month period, and has involved testing of over 300 test samples from over 100 consecutive patients. Clinical assessment by 4T score was supplemented by laboratory tests that comprised both immunological [lateral flow ('STiC'), chemiluminescence (AcuStar; HIT-IgG(PF4-H) ), ELISA (Asserachrom HPIA IgG)] and functional assays [SRA, platelet aggregation using whole blood ('Multiplate') and platelet rich plasma ('LTA')]...
April 17, 2018: Pathology
https://www.readbyqxmd.com/read/29678259/newborn-screening-for-lysosomal-storage-disorders
#16
Sharon Anderson
Lysosomal storage disorders (LSDs) are a heterogeneous group of approximately 50 rare inherited metabolic conditions that result from enzyme deficiencies that interfere with lysosome function. Although often grouped together, there is great variability regarding age of onset, severity, treatment, and outcomes for each disorder and subtype. Currently, laboratory methods are available to test newborns for seven of these conditions. Although newborn screening programs remain state-based, each at a different phase of condition review and implementation, if newborn screening for LSDs has not yet been adopted by the state within which you practice, it likely will...
May 2018: Journal of Pediatric Health Care
https://www.readbyqxmd.com/read/29678220/analysis-of-the-vidas-%C3%A2-staph-enterotoxin-iii-set3-for-detection-of-staphylococcal-enterotoxins-g-h-and-i-in-foods
#17
Jennifer M Hait, Angela T Nguyen, Sandra M Tallent
Background : Staphylococcal food poisoning (SFP) frequently causes illnesses worldwide. SFP occurs from the ingestion of staphylococcal enterotoxins (SEs) preformed in foods by enterotoxigenic strains of Staphylococcus species, primarily S. aureus . SEG, SEH, and SEI induce emesis and have been implicated in outbreaks. Immunological-based methods are deemed the most practical methods for the routine analysis of SEs in foods given their ease of use, sensitivity, specificity, and commercial availability. These kits are routinely used to test for SEA-SEE...
April 20, 2018: Journal of AOAC International
https://www.readbyqxmd.com/read/29678185/the-intrathecal-expression-and-pathogenetic-role-of-th17-cytokines-and-cxcr2-binding-chemokines-in-tick-borne-encephalitis
#18
Sambor Grygorczuk, Renata Świerzbińska, Maciej Kondrusik, Justyna Dunaj, Piotr Czupryna, Anna Moniuszko, Agnieszka Siemieniako, Sławomir Pancewicz
BACKGROUND: Tick-borne encephalitis (TBE) is a clinically variable but potentially severe Flavivirus infection, with the outcome strongly dependent on secondary immunopathology. Neutrophils are present in cerebrospinal fluid (CSF) of TBE patients, but their pathogenetic role remains unknown. In animal models, neutrophils contributed both to the Flavivirus entry into central nervous system (CNS) and to the control of the encephalitis, which we attempted to evaluate in human TBE. METHODS: We analyzed records of 240 patients with TBE presenting as meningitis (n = 110), meningoencephalitis (n = 114) or meningoencephalomyelitis (n = 16) assessing CSF neutrophil count on admission and at follow-up 2 weeks later, and their associations with other laboratory and clinical parameters...
April 20, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29677941/automated-differentiation-of-incident-and-prevalent-cases-in-primary-care-computerised-medical-records-cmr
#19
Nadia Smith, Valerie Livina, Rachel Byford, Filipa Ferreira, Ivelina Yonova, Simon de Lusignan
Identifying incident (first or new) episodes of illness is critical in sentinel networks to inform about the seasonal onset of diseases and to give early warning of epidemics, as well as differentiating change in health service utilization from change in pattern of disease. The most reliable way of differentiating incident from prevalent cases is through the clinician assigning episode type to the patient's computerized medical record (CMR). However, episode type assignment is often made inconsistently. The objective of this collaborative study between the Royal College of General Practitioners Research and Surveillance Centre (RCGP RSC), University of Surrey and the National Physical Laboratory (NPL) is to develop a methodology to reconstruct missing or miscoded episode types...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677913/implementation-of-fast-healthcare-interoperability-resources-for-an-integration-of-laboratory-and-hospital-information-systems
#20
Georgy Kopanitsa, Alexandr Ivanov
Electronic exchange of medical data between clinics and test centers makes the testing process more efficient, enables continuity of care record and reuse of medical data. The presented project employs HL 7 FHIR approach to model clinical concepts for the medical data exchange between a test center and different hospitals. Using a standard FHIR editor we have modeled 1226 observation profiles, 2396 commercial tests profiles that are mapped to 3249 production tests profiles. We have also defined a concept of an order and developed RESTfull API protocol to facilitate the ordering process...
2018: Studies in Health Technology and Informatics
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