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https://www.readbyqxmd.com/read/29036607/endoscopic-and-histopathologic-reflux-associated-mucosal-damage-in-the-remnant-esophagus-following-transthoracic-esophagectomy-for-cancer-5-year-long-term-follow-up
#1
H F Fuchs, H M Schmidt, M Meissner, S Brinkmann, M Maus, M Bludau, W Schröder, A H Hölscher, J M Leers
Gastroesophageal reflux is a common problem following esophagectomy and reconstruction with gastric interposition. Despite a routine prescription of proton pump inhibitors, reflux-associated mucosal damage in the remnant esophagus is frequently observed. Purpose of this study is to evaluate mucosal damage in the esophageal remnant during long-term follow-up and to compare the prevalence of this damage between the subgroups of esophageal squamous cell and adenocarcinoma. All patients undergoing transthoracic Ivor-Lewis esophagectomy were prospectively entered in our IRB approved database...
September 21, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29036528/prediction-of-pathologic-responders-to-neoadjuvant-chemoradiotherapy-by-diffusion-weighted-magnetic-resonance-imaging-in-locally-advanced-esophageal-squamous-cell-carcinoma-a-prospective-study
#2
Q-W Li, B Qiu, B Wang, D-L Wang, S-H Yin, H Yang, J-L Liu, J-H Fu, M-Z Liu, C-M Xie, H Liu
This study aims to investigate the role of diffusion-weighted magnetic resonance imaging (DW-MRI) in ESCC patients receiving neoadjuvant concurrent chemoradiotherapy (CCRT), and the efficacy of apparent diffusion coefficient (ADC) values in predicting pathologic response to neoadjuvant CCRT. Twenty-eight locally advanced ESCC patients treated with neoadjuvant CCRT followed by radical resection were prospectively enrolled. DW-MRI was recommended to be performed within 2 weeks before and 4-6 weeks after neoadjuvant CCRT...
September 27, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29034995/mir-1-suppresses-the-proliferation-and-promotes-the-apoptosis-of-esophageal-carcinoma-cells-by-targeting-src
#3
Zhicong Liao, Xiaojun Wang, Hongwei Liang, Ao Yu, Uzair Ur Rehman, Qian Fan, Yue Hu, Chen Wang, Zhen Zhou, Tao Wang
Nonreceptor tyrosine kinase c-Src, also known as Src, is a potent oncogene involved in a series of biological processes including cell growth, differentiation, and apoptosis; however, its expression pattern and function in esophageal cancer is poorly addressed. In this study, abnormal overexpression of Src protein was observed in esophageal cancer tissues, which fuelled the speculation that microRNA-mediated posttranscriptional regulatory mechanism might be involved. Bioinformatic analyses were applied to identify miRNAs that could potentially target Src...
October 16, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/29033778/a-case-of-basaloid-squamous-cell-carcinoma-of-polypoid-type-in-the-esophagus
#4
Ki Hun Lee, Sang Jin Lee, Hak Soo Kim, Sung Eun Kim, Soo Yong Choi, Hyun Ju Lee, Suk Hun Ha, Kwang Hoon Oh, Dae-Woon Eom
Basaloid squamous cell carcinoma of the esophagus is very rare. Further, polypoid type of esophageal cancer is also rare. We have recently treated a case of basaloid squamous cell carcinoma which presented as a 1.3-cm esophageal polyp. A 48-year-old woman was referred to our hospital because of a polypoid mass at 36 cm distance from the upper incisor on endoscopic examination, and the result of the biopsy was basaloid squamous cell carcinoma. The patient underwent Ivor Lewis operation with lymph node dissection...
September 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/29033590/sitting-time-and-occupational-and-recreational-physical-activity-in-relation-to-the-risk-of-esophageal-squamous-cell-carcinoma
#5
Pengxiang Chen, Qingxu Song, Jie Han, Huapu Xu, Tong Chen, Jiaqi Xu, Yufeng Cheng
BACKGROUNDS: Sitting time and physical activity are associated with cancer risk; however, their roles in the development of esophageal squamous cell carcinoma (ESCC) are inconclusive. This study aimed to investigate the effects of total sitting time, occupational activity time (OAT), and recreational activity time (RAT) on ESCC risk. METHODS: Five hundred fifty-seven ESCC patients and 543 healthy controls matched by sex and age were recruited for this study. Conditional logistic regression was performed to obtain odds ratios (ORs) and 95% confidence intervals (CIs)...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29033183/the-overexpression-and-predictive-significance-of-mmp-12-in-esophageal-squamous-cell-carcinoma
#6
Fei Han, Suxia Zhang, Long Zhang, Qiongyu Hao
Matrix metalloproteinase (MMP)-mediated degradation of the extracellular matrix is a major factor for tumor invasion and metastasis. MMP-12, as metalloelastase, its function in tumor progression remains contradictory. This study was undertaken to investigate the role of MMP-12 in esophageal squamous cell carcinoma (ESCC). We analyzed the protein expression of MMP-12 and its association with clinicopatholigical parameters, as well as survival analysis. MMP-12 was highly expressed in tumor cells comparing with normal epithelial cells...
September 28, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29033014/clinicopathologic-features-of-submucosal-esophageal-squamous-cell-carcinoma
#7
Manabu Emi, Jun Hihara, Yoichi Hamai, Takaoki Furukawa, Yuta Ibuki, Morihito Okada
BACKGROUND: The prognoses of submucosal esophageal squamous cell carcinoma patients vary. Patients with favorable prognoses may receive less invasive or nonsurgical interventions, whereas patients with poor prognoses or advanced esophageal cancer may require aggressive treatments. We sought to identify prognostic factors for patients with submucosal esophageal squamous cell carcinoma, focusing on lymph node metastasis and recurrence. METHODS: We included 137 submucosal esophageal squamous cell carcinoma patients who had undergone transthoracic esophagectomy with systematic extended lymph node dissection...
October 12, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29030780/endoscopic-treatment-versus-esophagectomy-for-early-stage-esophageal-cancer-a-population-based-study-using-propensity-score-matching
#8
Yuan Zeng, Wenhua Liang, Jun Liu, Jianxing He
BACKGROUND: Endoscopic treatment (ET) is an alternative for selected patients with early-stage esophageal cancer. The primary aim of this study was to compare overall survival (OS) and esophageal cancer-specific survival (ECSS) of such patients after ET or esophagectomy. METHODS: Propensity score matching (PSM) and Cox regression analysis were used to compare OS and ECSS of 2661 patients with ET or esophagectomy for early-stage (Tis-T1N0M0) disease. Patient information was retrieved from the Surveillance, Epidemiology, and End Results database...
October 13, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29030675/evaluation-of-prognostic-factors-for-esophageal-squamous-cell-carcinoma-treated-with-neoadjuvant-chemoradiotherapy-followed-by-surgery
#9
Yoichi Hamai, Jun Hihara, Manabu Emi, Takaoki Furukawa, Yuji Murakami, Ikuno Nishibuchi, Yuta Ibuki, Ichiko Yamakita, Tomoaki Kurokawa, Yasushi Nagata, Morihito Okada
BACKGROUND: Intensive trimodality therapy is needed for locally advanced esophageal squamous cell carcinoma (ESCC). However, some patients develop recurrence and die of cancer even after trimodality therapy. METHODS: We evaluated prognostic factors based on data from 125 patients with ESCC who underwent neoadjuvant chemoradiotherapy (NCRT) comprising concurrent chemotherapy and 40 Gy of radiation, followed by curative-intent esophagectomy. RESULTS: Thirty-four (27...
October 13, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29029520/prognostic-role-of-intratumoral-il-17a-expression-by-immunohistochemistry-in-solid-tumors-a-meta-analysis
#10
Shimin Wang, Zhi'an Li, Guoming Hu
IL-17A is an important proinflammatory cytokine which is frequently elevated in tumor microenvironment. However, the role of intratumoral IL-17A in solid tumors remains controversial. Herein, we conducted a meta-analysis to assess the prognostic impact of intratumoral IL-17A in patients with solid tumor. PubMed and EBSCO were searched to identify the studies evaluating the associations between intratumoral IL-17A measured by immunohistochemistry (IHC) and overall survival (OS) and disease-free survival (DFS) in solid tumors...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29029485/fzd7-is-a-novel-prognostic-marker-and-promotes-tumor-metastasis-via-wnt-and-emt-signaling-pathways-in-esophageal-squamous-cell-carcinoma
#11
Ting-Ting Cao, Di Xiang, Bei-Lei Liu, Tu-Xiong Huang, Bin-Bin Tan, Chui-Mian Zeng, Zhong-Yuan Wang, Xiao-Yan Ming, Li-Yi Zhang, Guangyi Jin, Feng Li, Jian-Lin Wu, Xin-Yuan Guan, Desheng Lu, Li Fu
Frizzled (FZD) proteins are receptors for secreted WNT proteins and play a critical role in the malignant progression of various cancers. However, the role of human FZD family members in esophageal squamous cell carcinoma (ESCC) was rarely investigated. In this study, we found that the FZD7 gene was the most commonly up-regulated FZD member in ESCC cell lines compared with other FZDs. TMA studies further validated that FZD7 protein was up-regulated in 165 of 252 (65.5%) informative ESCC patients and significantly correlated with poor overall survival (P=0...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29029460/vrk1-promotes-cisplatin-resistance-by-up-regulating-c-myc-via-c-jun-activation-and-serves-as-a-therapeutic-target-in-esophageal-squamous-cell-carcinoma
#12
Zhen-Chuan Liu, Kuo Cao, Zhao-Hua Xiao, Liang Qiao, Xue-Qing Wang, Bin Shang, Yang Jia, Zhou Wang
Esophageal squamous cell carcinoma (ESCC) is a common malignant disease characterized by poor prognosis. Chemoresistance remains a major cause of ESCC relapse. Vaccinia-related kinase 1 (VRK1) has previously been identified as a cancer-related gene. However, there is little research demonstrating an association between VRK1 and ESCC. In this study, we show that VRK1 is overexpressed in ESCC primary tumor samples and cell lines. VRK1 expression was significantly correlated with clinical characteristics and predicted poor outcomes in ESCC patients...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29029429/twist1-is-highly-expressed-in-cancer-associated-fibroblasts-of-esophageal-squamous-cell-carcinoma-with-a-prognostic-significance
#13
So-Young Yeo, Sang-Yun Ha, Keun-Woo Lee, Yan Cui, Zhao-Ting Yang, Yan-Hua Xuan, Seok-Hyung Kim
Cancer-associated fibroblasts (CAFs) play important roles in cancer progression. Twist1 was recently reported to be a key regulator of CAFs in gastric cancer, but its role in other types of cancer remains unclear, especially for esophageal squamous cell carcinoma (ESCC). We assessed the Twist1 expression on stromal fibroblasts using immunohistochemistry in 169 tissue specimens from ESCC patients, and performed in vitro and in vivo experiments to confirm the role of Twist1 in CAFs of ESCC. And we investigated the biological pathways that are activated in Twist1-high ESCC using The Cancer Genome Atlas (TCGA) data...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29029421/prognostic-value-of-supraclavicular-nodes-and-upper-abdominal-nodes-metastasis-after-definitive-chemoradiotherapy-for-patients-with-thoracic-esophageal-squamous-cell-carcinoma
#14
Xue Li, Lujun Zhao, Wencheng Zhang, Chengwen Yang, Zhen Lian, Shuai Wang, Ningbo Liu, Qingsong Pang, Ping Wang, Jinming Yu
The purpose of this study is to assess the prognostic value of supraclavicular nodes, left gastric nodes, celiac nodes and common hepatic nodes metastasis in esophageal squamous cell carcinoma (ESCC) treated with definitive radiotherapy. A total of 293 ESCC patients treated with radiotherapy or chemoradiotherapy entered the study. The results showed that the presence of supraclavicular nodes (χ(2) = 0.075, P = 0.785) and left gastric nodes (χ(2) = 3.603, P = 0.058) metastasis had no significant influence on survival, while celiac nodes (χ(2) = 33...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29029411/nestin-expression-involves-invasiveness-of-esophageal-carcinoma-and-its-downregulation-enhances-paclitaxel-sensitivity-to-esophageal-carcinoma-cell-apoptosis
#15
Jinghang Zhang, Jiateng Zhong, Jian Yu, Jinsong Li, Wenyu Di, Ping Lu, Xiaoyu Yang, Weixing Zhao, Xianwei Wang, Wei Su
Paclitaxel has been generally used to treat primary and metastatic esophageal carcinoma. It has been shown that nestin is highly expressed in esophageal carcinoma and that there is a strong association of nestin expression with poor prognosis in esophageal carcinoma patients. In this study, using immunohistochemistry, in situ hybridization and Western blotting we demonstrated that nestin was overexpressed in the invasive esophageal carcinoma. To further elucidate whether nestin inhibition could enhance paclitaxel sensitivity to esophageal carcinoma cells, we applied nestin siRNA in esophageal squamous cell carcinoma Eca-109 cells...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29026004/oxidative-stress-regulates-cellular-bioenergetics-in-esophageal-squamous-cell-carcinoma-cell
#16
Xiaolong Zhang, Linhua Lan, Lili Niu, Juping Lu, Changxi Li, Miaomiao Guo, Shouyong Mo, Jing Lu, Yongzhang Liu, Bin Lu
The aim of this study was to explore the effects of oxidative stress induced by CoCl2 and H2O2 on the regulation of bioenergetics of esophageal squamous cell carcinoma (ESCC) cell line TE-1 and analyze its underlying mechanism. Western blot results showed that CoCl2 and H2O2 treatment of TE-1 cells led to significantly reduction of mitochondrial respiratory chain complex subunits expression and increasing intracellular reactive oxygen species (ROS) production.  We further found that TE-1 cells treated with CoCl2, a hypoxia-mimicking reagent, dramatically reduced the oxygen consumption rate (OCR) and increased the extracellular acidification rate (ECAR)...
October 12, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/29024498/feasibility-and-efficiency-of-concurrent-chemoradiotherapy-with-capecitabine-and-cisplatin-versus-radiotherapy-alone-for-elderly-patients-with-locally-advanced-esophageal-squamous-cell-carcinoma-experience-of-two-centers
#17
Fangjie Chen, Hui Luo, Ligang Xing, Ning Liang, Jian Xie, Jiandong Zhang
BACKGROUND: The purpose of this retrospective study was to evaluate the feasibility and efficacy of definitive concurrent chemoradiotherapy (CCRT) with capecitabine and cisplatin for elderly patients with locally advanced esophageal squamous cell carcinoma. METHODS: A total of 90 patients were included from two different centers. Forty-nine patients were treated with CCRT consisting of capecitabine (850 mg/m(2) , oral, twice a day for 1-14 days) and cisplatin (20 mg/m(2) ) weekly during radiotherapy (RT)...
October 12, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/29022485/prevalence-of-%C3%AE-iii-tubulin-tubb3-expression-in-human-normal-tissues-and-cancers
#18
Fermín Person, Waldemar Wilczak, Claudia Hube-Magg, Christoph Burdelski, Christina Möller-Koop, Ronald Simon, Mercedes Noriega, Guido Sauter, Stefan Steurer, Susanne Burdak-Rothkamm, Frank Jacobsen
Microtubules are multifunctional cytoskeletal proteins that are involved in crucial cellular roles including maintenance of cell shape, intracellular transport, meiosis, and mitosis. Class III beta-tubulin (βIII-tubulin, also known as TUBB3) is a microtubule protein, normally expressed in cells of neuronal origin. Its expression was also reported in various other tumor types, such as several types of lung cancer, ovarian cancer, and esophageal cancer. TUBB3 is of clinical relevance as overexpression has been linked to poor response to microtubule-targeting anti-cancer drugs such as taxanes...
October 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/29022200/high-expression-of-the-mitophagy-related-protein-pink1-is-associated-with-a-poor-response-to-chemotherapy-and-a-poor-prognosis-for-patients-treated-with-neoadjuvant-chemotherapy-for-esophageal-squamous-cell-carcinoma
#19
Kotaro Yamashita, Hiroshi Miyata, Tomoki Makino, Yasunori Masuike, Haruna Furukawa, Koji Tanaka, Yasuhiro Miyazaki, Tsuyoshi Takahashi, Yukinori Kurokawa, Makoto Yamasaki, Kiyokazu Nakajima, Shuji Takiguchi, Eiichi Morii, Masaki Mori, Yuichiro Doki
BACKGROUND: Autophagy plays a major role in cellular homeostasis and is implicated in cancer progression. Damaged mitochondria are scavenged and eliminated by mitochondrial autophagy, referred to as mitophagy, which can promote cancer cell survival. This study investigated the expression and effects of the autophagy-related protein LC3 and the mitophagy-related protein Pink1 in human esophageal squamous cell carcinoma (ESCC). METHODS: Both LC3 and Pink1 were analyzed by immunohistochemistry in tissues from 217 ESCC patients, including 159 patients undergoing neoadjuvant chemotherapy...
October 11, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29020885/identification-of-pa28%C3%AE-as-a-potential-novel-biomarker-in-human-esophageal-squamous-cell-carcinoma
#20
Jin-Yan Chen, Li Xu, Wei-Min Fang, Jun-Yong Han, Kun Wang, Kun-Shou Zhu
Esophageal squamous cell carcinoma (ESCC) is one of the most common and serious malignancies in China. However, the exact mechanisms of tumor formation and progression are unclear. As late diagnosis and poor therapeutic efficacy result in lower survival rates, identifying biomarkers for early detection, prognostic evaluation, and recurrence monitoring of ESCC is necessary. Here we analyzed 10 protein expression profiles of ESCC core tissues and paired normal esophageal epithelial tissues using two-dimensional gel electrophoresis...
October 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
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