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https://www.readbyqxmd.com/read/29931989/retroperitoneal-schwannoma
#1
Carlos Alventosa Mateu, Génesis Aurora Castillo López, Cecilia Albert Antequera
Schwannoma is a mesenchymal tumor that is mainly located in the peripheral nerves or the central nervous system. Its retroperitoneal location is rare and commonly asymptomatic. Thus, it is usually diagnosed when imaging tests are performed for other purposes. The clinical course of Schwannoma is benign but it also has malignant potential. Therefore, surgical resection is the treatment of choice. The definitive diagnosis is anatomopathological. In this context, we present a patient with retroperitoneal Schwannoma...
June 22, 2018: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29931542/inflammatory-features-including-symptoms-increased-serum-interleukin-6-and-c-reactive-protein-in-igg4-related-vascular-diseases
#2
Satomi Kasashima, Atsuhiro Kawashima, Fuminori Kasashima, Masamitsu Endo, Yasushi Matsumoto, Kengo Kawakami
Immunoglobulin (IgG) 4-related diseases (IgG4-RDs) are fibro-inflammatory conditions characterized by tumorous swelling and serum IgG4 levels. Intrapelvic IgG4-RD has been subclassified according to the localization site and aortic shape as IgG4-related aortic aneurysms (IgG4-AAs), periaortitis (IgG4-PA), and retroperitoneal fibrosis (IgG4-RF). The IgG4-AA pathogenesis would involve interleukin (IL)-6 upregulation, and Th2-predominant and Treg-activated immune conditions. We characterized the features of intrapelvic IgG4-RD lesions, including presence of vascular lesions...
June 21, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29928214/complete-remission-of-recurrent-retroperitoneal-liposarcoma-after-the-administration-of-gemcitabine-and-docetaxel-as-first-line-adjuvant-chemotherapy-a-case-report
#3
Filipe Rocha Da Silva, Alan Vitor Jerônimo Lima, Erick Willian Rocha Pereira Albuquerque, Carlos Augusto Moreira-Silva, Nicole Maués Flexa De Oliveira, Jorge Alberto Langbeck Ohana, Luís Eduardo Werneck Carvalho
Retroperitoneal liposarcoma is a rare type of cancer. Relapse after surgery is frequent, and relapsing tumors tend to be more aggressive and less differentiated each episode, worsening the prognosis. This report describes the case of a 42-year-old female diagnosed with retroperitoneal liposarcoma after complete tumor resection. At the 3-month follow-up, another expansive lipomatous mass in the retroperitoneal area almost the same size as the previous one was detected. The patient underwent a new surgery, followed by first-line treatment with a gemcitabine- and docetaxel-based regimen for 8 cycles...
May 2018: Case Reports in Oncology
https://www.readbyqxmd.com/read/29922019/retroperitoneal-paraganglioma-in-a-patient-with-fontan-the-hypoxia-connection
#4
Shriprasad R Deshpande, Priyanka Patel, Neill Videlefsky, Dellys M Soler Rodriguez, Rene Romero, Matthew S Clifton
Paragangliomas are rare neuroendocrine tumors where hypoxia-inducible factor plays a critical role in tumorigenesis. It has been suggested that patients with congenital heart disease, in particular, may have cellular environment and relative hypoxia favorable to the development of these neuroendocrine tumors. Here, we present a case of an 11-year-old child with hypoplastic left heart syndrome previously palliated with Fontan procedure, diagnosed with paraganglioma on surveillance imaging. We present the clinical course, intervention, and outcome as well as review the possible contributory mechanisms...
May 2018: Annals of Pediatric Cardiology
https://www.readbyqxmd.com/read/29915482/aggressive-surgical-approach-for-treatment-of-primary-and-recurrent-retroperitoneal-soft-tissue-sarcoma
#5
Antonio Chiappa, Emilio Bertani, Gabriella Pravettoni, Andrew Paul Zbar, Diego Foschi, Giuseppe Spinoglio, Bernardo Bonanni, Gianluca Polvani, Federico Ambrogi, Maria Laura Cossu, Carlo Ferrari, Marco Venturino, Cristiano Crosta, Luca Bocciolone, Roberto Biffi
To analyze treatment and survival in a series of resected patients with primary or recurrent retroperitoneal sarcoma (RPS) treated and prospectively followed at a single institution. Between July 1994 and December 2015, 89 patients (36 M, 53 F; mean age 60 years, range 25-79) were evaluated. For the purpose of analysis, complete resection was defined as removal of gross tumor with histologically confirmed clear resection margins. Eighty-three out of the 89 patients (93%), 46 of whom affected by primary RPS, and 37 by recurrent RPS, underwent surgical exploration...
April 2018: Indian Journal of Surgery
https://www.readbyqxmd.com/read/29905010/plasma-cell-free-dna-quantification-is-highly-correlated-to-tumor-burden-in-children-with-neuroblastoma
#6
Xisi Wang, Lijun Wang, Yan Su, Zhixia Yue, Tianyu Xing, Wen Zhao, Qian Zhao, Chao Duan, Cheng Huang, Dawei Zhang, Mei Jin, Xianfeng Cheng, Shenglan Chen, Yi Liu, Xiaoli Ma
To evaluate plasma cell-free DNA (cfDNA) as a promising biomarker for neuroblastoma (NB) tumor burden. Seventy-nine eligible patients with newly diagnosed NB were recruited from Beijing Children's Hospital between April 2016 and April 2017. Additionally, from September 2011 to June 2017, 79 patients with stable NB were evaluated with a median follow-up time of 21 months. Approximately 2 mL of peripheral blood was drawn upon enrollment, and plasma cfDNA levels were measured via quantitative polymerase chain reaction (qPCR)...
June 14, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29904477/magnetic-resonance-neurography-in-the-diagnosis-of-a-retroperitoneal-ganglioneuroma-case-report-and-literature-review
#7
Cláudio Régis Sampaio Silveira, Clarissa Gadelha Maia Vieira, Brenda Machado Pereira, Edson Lopes, Gunter Gerson, Daniel Gurgel Fernandes Távora, Avneesh Chhabra
Magnetic resonance neurography is a technique for identifying anatomy and pathologic lesions of nerves, and has emerged as a helpful technique for localizing lesions and elucidating the underlying etiology. Ganglioneuromas are highly differentiated benign tumors. This lesion is rare and exhibits undetermined symptoms, the features of using the magnetic resonance neurography are a great ally to determine its diagnosis. The authors illustrate a case of retroperitoneal ganglioneuroma emphasizing its image characteristics using magnetic resonance neurography with the diagnosis confirmed by histopathological examination...
April 2018: Radiology Case Reports
https://www.readbyqxmd.com/read/29904248/devascularization-of-the-superior-mesenteric-vein-without-reconstruction-during-surgery-for-retroperitoneal-liposarcoma-a-case-report-and-review-of-literature
#8
Run-Chen Miao, Yong Wan, Xiao-Gang Zhang, Xing Zhang, Yan Deng, Chang Liu
A 61-year-old female patient with chronic hepatitis B virus infection was diagnosed with liposarcoma in a community hospital. Fine needle aspiration biopsy confirmed the diagnosis of well-differentiated liposarcoma. Abdominal computed tomographic angiography (CTA) showed that the mass adhered to and constricted the main trunk and branch of the superior mesenteric vein (SMV), especially the ileocolic vein, and collateral circulation was observed during the vascular reconstruction scan. The abdominal liposarcoma was resected...
June 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29896078/extremely-rare-presentation-of-burned-out-testicular-tumor
#9
Mojtaba Ameli, Naser Yousefzade, Saeed Farhadiniaki, Leila Gholamimahtaj
It is commonly accepted to consider retroperitoneal germ cell tumors as the metastasis of a viable or burned-out testicular tumor. In such cases, orchiectomy should be performed since the burned-out site in the testis could continue to harbor malignancy despite systemic chemotherapy. A 45-year-old male presented as an outpatient with complaints of back pain. He was diagnosed with a retroperitoneal mass and a palpable testis mass. He underwent radical orchiectomy. Pathological study revealed a burned-out tumor...
May 2018: International Journal of Health Sciences
https://www.readbyqxmd.com/read/29891460/-three-dimensional-spatial-measurement-versus-conventional-ct-planning-in-laparoscopic-partial-nephrectomy-for-renal-tumors
#10
Zheng-Fei Hu, Shi-Dong Lv, Jian-Feng Huang, Lin Zhang, Chan-Tao Huang, Yi-Wen Li, Wen-Hua Huang, Jian-Ping Ye, Qiang Wei
OBJECTIVE: To analyze the advantages of spatial measurement of anatomical parameters in a 3D model in surgical planning for laparoscopic partial nephrectomy (LPN). METHODS: From February, 2016 to October, 2017, 37 patients diagnosed with T1 renal mass underwent LPN based on 3D reconstruction after enhanced CT scanning using the Uromedix-3D system (group A), and another 38 patients received LPN with conventional CT planning (group B). The anatomical parameters were measured in the reconstructed 3D model and the demographic data, surgical outcome and postoperative data were compared between the two groups...
May 20, 2018: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/29885916/massive-splenomegaly-due-to-b-cell-lymphoma-a-case-report
#11
M Djokic, B Plesnik, M Petric, B Trotovsek
INTRODUCTION: Massive splenomegaly is indicated by spleen weight exceeding 1000 g and largest spleen dimension greater than 20 cm Poulin et al. (1998). In many cases, splenectomy is the treatment of choice for massive splenomegaly because it releases the pressure on adjacent organs and also provides a definitive histopathological diagnosis of the underlying cause Iriyama et al. (2010), Radhakrishnan (2018). PRESENTATION OF CASE: Herein we present a clinical case of disseminated diffuse large B - cell lymphoma, clinical stage IV, with massive splenomegaly...
May 29, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29872593/retroperitoneal-metastasis-abutting-small-bowel-a-novel-magnetic-resonance-guided-radiation-approach
#12
Ahmed I Ghanem, Carri Glide-Hurst, M Salim Siddiqui, Indrin J Chetty, Benjamin Movsas
Stereotactic body radiation therapy (SBRT) is an option for selected patients with metastatic disease. However, sometimes these lesions are located in such close proximity to critical normal structures that the use of safe tumoricidal SBRT doses is not achievable. Here we present a case in which real-time imaging and tracking with a magnetic resonance linear accelerator (MR-LINAC) provided a novel treatment approach and enabled safe treatment of the tumor using SBRT. Our case is a 69-year-old female who presented with localized recurrent small cell lung cancer with a retroperitoneal (FDG-avid) soft tissue lesion measuring 2...
April 2, 2018: Curēus
https://www.readbyqxmd.com/read/29867463/metformin-mitigates-fibrosis-and-glucose-intolerance-induced-by-doxorubicin-in-subcutaneous-adipose-tissue
#13
Luana A Biondo, Helena A Batatinha, Camila O Souza, Alexandre A S Teixeira, Loreana S Silveira, Maria I Alonso-Vale, Lila M Oyama, Michele J Alves, Marilia Seelaender, José C R Neto
Doxorubicin (DX) is a chemotherapeutic drug that is used in clinical practice that promotes deleterious side effects in non-tumor tissues such as adipose tissue. We showed that DX leads to extensive damage in adipose tissue via a disruption in 5'-adenosine monophosphate-activated protein kinase (AMPK) and PPAR-gamma signaling. Thus, we investigated whether co-treatment with the biguanide drug metformin (MET) could prevent the side effects of DX through the activation of AMPK in adipose tissue. The goal of the present study was to verify the effects of DX and adjuvant MET treatment in subcutaneous adipose tissue (SAT) and to determine whether MET could protect against chemotherapy-induced side effects...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29867073/first-case-report-of-a-huge-giant-cell-tumor-of-soft-tissue-originating-from-the-retroperitoneum
#14
Shinji Kishi, Hiroyuki Monma, Hiroshige Hori, Shoichi Kinugasa, Masayo Fujimoto, Takeshi Nakamura
BACKGROUND Giant cell tumor of soft tissue (GCT-ST) is a rare disease generally generated from superficial tissue. We report an extremely rare case of giant cell tumor of soft tissue arising from retroperitoneal tissue. CASE REPORT A 78-year-old man visited our medical center with the chief complaint of fatigue and weight loss for 1 month. He had a hard and immobilized mass without pain in the left upper quadrant. Contrast-enhanced CT showed a huge tumor (22×20×16 cm) in the retroperitoneal space, and it invaded into the stomach, colon, pancreas, spleen, and left kidney...
June 5, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29849605/the-use-of-modified-templates-in-early-and-advanced-stage-nonseminomatous-germ-cell-tumor
#15
REVIEW
Timothy A Masterson, Clint Cary
The surgical management of both early and advanced stage germ cell tumors of the testis remains a complex process of surgical decision making to maximize oncologic control while minimizing morbidity. Over the past 5 decades, the evolution of the surgical template for retroperitoneal lymphadenectomy (RPLND) has resulted in important modifications to achieve these goals. In this review, we will characterize the historical motivating factors that led to the modified template, outline patient and clinical factors in selecting these approaches in both early and advanced stage disease, and briefly discuss future horizons for their implementation...
2018: Advances in Urology
https://www.readbyqxmd.com/read/29808539/laparoscopic-excision-of-a-retroperitoneal-schwannoma-a-case-report
#16
Manato Ohsawa, Masashi Miguchi, Masanori Yoshimitsu, Koichi Oishi, Toshihiko Kohashi, Jun Hihara, Hidenori Mukaida, Mayumi Kaneko, Hiroyuki Egi, Hideki Ohdan, Naoki Hirabayashi
Schwannomas are tumors originating from the Schwann cells of the peripheral nerve sheath. Only 1%-3% of schwannomas reportedly occur in the pelvis. In a 67-year-old man, a pelvic mass that was 52 mm in diameter was incidentally diagnosed during a preoperative CT evaluation for prostate cancer. Preoperative 3-D reconstruction CT showed that the feeding artery to the tumor originated from the internal iliac artery and the drainage vein from the internal iliac vein. Each vessel could be isolated, clipped, and cut with minimal bleeding...
May 28, 2018: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/29808086/adjuvant-therapy-for-stage-ib-germ-cell-tumors-one-versus-two-cycles-of-bep
#17
REVIEW
Robert A Huddart, Alison M Reid
Testicular germ cell tumours are the commonest tumours of young men and are broadly managed either as pure seminomas or as 'nonseminomas'. The management of Stage 1 nonseminomatous germ cell tumours (NSGCTs), beyond surgical removal of the primary tumour at orchidectomy, is somewhat controversial. Cancer-specific survival rates in these patients are in the order of 99% regardless of whether surveillance, retroperitoneal lymph node dissection, or adjuvant chemotherapy is employed. However, the toxicities of these treatment modalities differ...
2018: Advances in Urology
https://www.readbyqxmd.com/read/29804543/giant-intrascrotal-embryonal-rhabdomyosarcoma-in-an-adult-a-case-report-and-review-of-the-literature
#18
Wentao Gong, Qingqiang Gao, Zhipeng Xu, Yutian Dai
BACKGROUND: Intrascrotal embryonal rhabdomyosarcoma in adults is a rare tumor with high aggression and a poor prognosis. We report our patient's case and review the relevant literature to improve the understanding of this rare disease. CASE PRESENTATION: A 21-year-old Han Chinese man presented to our hospital with a right intrascrotal mass of 1 year's duration. His physical examination revealed an enlarged right scrotum containing a huge tender mass measuring about 10 × 7 cm...
May 28, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29797115/long-term-outcome-after-surgery-for-a-localized-retroperitoneal-soft-tissue-sarcoma-in-elderly-patients-results-from-a-retrospective-single-center-study
#19
I Sourrouille, R Macovei, M Faron, C Le Péchoux, O Mir, J Adam, S Dumont, P Terrier, A Le Cesne, C Honoré
BACKGROUND: To evaluate short- and long-term results after curative surgery for a retroperitoneal sarcoma (RPS) in elderly patients. METHODS: We retrospectively analyzed data of all patients operated in our single, tertiary care center for a nonmetastatic RPS and identified patients aged 70 years and older. RESULTS: Among 296 patients with an RPS treated between 1994 and 2015, 60 (20%) were aged 70 years and older (median age 74 years; range 70-85)...
May 24, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29795773/hepatic-periportal-retroperitoneal-and-mesenteric-neurofibromatosis-in-von-recklinghausen-s-disease
#20
Kumail Khandwala, Zafar Sajjad, Summar-Un-Nisa Abbasi, Muhammad Usman Tariq
We present a rare case of histologically proven neurofibromatosis of the liver, hepatic hilum, retroperitoneum, and mesentery. An adult male who had been diagnosed with neurofibromatosis (NF) type 1 underwent a computed tomography (CT) scan for abdominal pain and vomiting. The CT scan showed a large low-attenuating lesion in the region of porta hepatis which was infiltrating along portal tracts into the liver, encasing the major vessels, and extending into the retroperitoneum and mesentery. Based on the radiological findings, a differential diagnosis of plexiform neurofibroma was given, although sarcomatous transformation could not have been entirely excluded from imaging alone...
February 28, 2018: Curēus
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