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https://www.readbyqxmd.com/read/28938566/screening-differential-circular-rna-expression-profiles-reveals-hsa_circ_0004018-is-associated-with-hepatocellular-carcinoma
#1
Liyun Fu, Ting Yao, Qingqing Chen, Xiaoyan Mo, Yaoren Hu, Junming Guo
Circular RNAs (circRNAs) have been emerged as an indispensable part of endogenous RNA network. However, the expression significance of circRNAs in hepatocellular carcinoma (HCC) is rarely revealed. The aim of this study was to determine the circRNA expression profile in HCC, and to investigate their clinical significances and relevant mechanisms for cancer progression. The global circRNA expression profile in HCC was measured by circRNA microarray. Levels of one representative circRNAs, hsa_circ_0004018, were confirmed by real-time reverse transcription-polymerase chain reaction...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938547/ptip-promotes-recurrence-and-metastasis-of-hepatocellular-carcinoma-by-regulating-epithelial-mesenchymal-transition
#2
Shusheng Leng, Mingyang Yang, Yanhua Zhao, Jingfeng Zhao, Zhijun Zeng, Yunpeng Yang, Jiatian Yuan, Bo Lv, Fan Jun, Bing Wang
Hepatocellular carcinoma (HCC) is one of the most lethal tumors worldwide, which is mainly due to the high recurrence and metastasis rate after hepatectomy. In this study, we found that PTIP expression was dramatically upregulated in human HCC tissues and cell lines. High expression of PTIP was shown to be associated with aggressive clinicopathological features, including liver cirrhosis, vascular invasion and advanced stage. In addition, PTIP overexpression was independently associated with shorter survival and increased HCC recurrence in patients...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28935394/case-report-an-hiv-patient-presenting-with-pancytopenia-hepatic-failure-and-coagulopathy-a-rare-small-cell-liver-carcinoma-with-diffuse-splenic-and-bone-marrow-metastasis-diagnosed-at-autopsy
#3
Joshua T Byers, Alejandro Mendoza, Daniel Wu, Jason S Kahlon, Xin Qing, Samuel W French
A 34-year old male with a giant condyloma acuminatum of the anus secondary to HIV infection presented to the emergency department with a persistent nose bleed lasting 2-3days, acute anemia, thrombocytopenia, and coagulopathy. The patient also had significant hepatosplenomegaly and elevated liver enzymes which were a new finding since the patient's last hospitalization 1-2month prior to the current admission. A bone marrow biopsy showed diffuse infiltration by carcinoma with neuroendocrine features. The patient quickly developed multi-organ injury, decompensated, and died...
September 18, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28935021/-one-case-about-primary-pulmonary-squamous-cell-carcinoma-%C3%A2-with-retinal-metastasis
#4
Jinxia Liu, Xiqian Gao, Mindan Sun
Lung cancer is a common malignant tumor in clinic. Morbidity and mortality are the first place in cancer, which seriously threaten the health of human beings. Due to the lack of effective and specific screening methods, most patients were found already at an advanced stage, and often combined with bone, brain, liver, adrenal and other parts of the metastasis. Symptoms of patient resulted from the primary tumor, metastatic spread, or paraneoplastic syndrome commonly cause the medical attention. For the syndrome related to the distant metastatic spread as the first manifestation, diagnosis would be a challenge...
September 20, 2017: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/28933364/targeting-h19-an-imprinted-long-non-coding-rna-in-hepatic-functions-and-liver-diseases
#5
REVIEW
Chad Pope, Shashank Mishra, Joshua Russell, Qingqing Zhou, Xiao-Bo Zhong
H19 is a long non-coding RNA regulated by genomic imprinting through methylation at the locus between H19 and IGF2. H19 is important in normal liver development, controlling proliferation and impacting genes involved in an important network controlling fetal development. H19 also plays a major role in disease progression, particularly in hepatocellular carcinoma. H19 participates in the epigenetic regulation of many processes impacting diseases, such as activating the miR-200 pathway by histone acetylation to inhibit the epithelial-mesenchymal transition to suppress tumor metastasis...
March 8, 2017: Diseases (Basel)
https://www.readbyqxmd.com/read/28931405/evaluating-a-preoperative-protocol-that-includes-magnetic-resonance-imaging-for-lymph-node-metastasis-in-the-cholangiocarcinoma-screening-and-care-program-cascap-in-thailand
#6
Metha Songthamwat, Nittaya Chamadol, Narong Khuntikeo, Jadsada Thinkhamrop, Supinda Koonmee, Nathaphop Chaichaya, Jeffrey Bethony, Bandit Thinkhamrop
BACKGROUND: Treatment planning especially liver resection in cholangiocarcinoma (CCA) depends on the extension of tumor and lymph node metastasis which is included as a key criterion for operability. Magnetic resonance imaging (MRI) offers a rapid and powerful tool for the detection of lymph node metastasis (LNM) and in the current manuscript is assessed as a critical tool in the preoperative protocol for liver resection for treatment of CCA. However, the accuracy of MRI to detect LNM from CCA had yet to be comprehensively evaluated...
September 20, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28930817/cronkhite-canada-syndrome-associated-with-colon-cancer-metastatic-to-liver-a-case-report
#7
Jing Wang, Lei Zhao, Nina Ma, Juanjuan Che, Huihui Li, Bangwei Cao
RATIONALE: Cronkhite-Canada Syndrome (CCS) is an idiopathic, nonhereditary syndrome haracterized by gastrointestinal (GI) polyposis and ectodermal changes including alopecia, onychatrophia, and pigmentation. CCS colon polyps were previously considered to be benign neoplasms. However, serrated adenoma was reported to be associated with malignant neoplasms in some cases of gastric and colorectal carcinomas, and esophageal cancers. Although malignant colon and gastric cancer have been reported in CCS, reports of distant metastasis have been rare in CCS...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28930164/liver-cancer-molecular-characterization-clonal-evolution-and-cancer-stem-cells
#8
REVIEW
Germana Castelli, Elvira Pelosi, Ugo Testa
Liver cancer is the second most common cause of cancer-related death. The major forms of primary liver cancer are hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA). Both these tumors develop against a background of cirrhotic liver, non-alcoholic fatty liver disease, chronic liver damage and fibrosis. HCC is a heterogeneous disease which usually develops within liver cirrhosis related to various etiologies: hepatitis B virus (HBV) infection (frequent in Asia and Africa), hepatitis C virus (HCV), chronic alcohol abuse, or metabolic syndrome (frequent in Western countries)...
September 20, 2017: Cancers
https://www.readbyqxmd.com/read/28929341/margin-status-is-still-an-important-prognostic-factor-in-hepatectomies-for-colorectal-liver-metastases-a-propensity-score-matching-analysis
#9
Riccardo Memeo, Vito de Blasi, Rene Adam, Diane Goéré, Tullio Piardi, Emilie Lermite, Olivier Turrini, Francis Navarro, Nicola de'Angelis, Antonio Sa Cunha, Patrick Pessaux
OBJECTIVE: The width of resection margin is still a matter of debate in case of colorectal liver metastasis resection. The aim of this study was to determine the risk factors for R1 resection. Once risk factors had been identified, patients were matched according to Fong's prognostic criteria, in order to evaluate whether R1 resection still remained a negative prognostic factor impacting overall and disease-free survival. METHODS: A total of 1784 hepatectomies were analyzed from a multicentric retrospective cohort of hepatectomies...
September 19, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28929029/association-of-rs1801157-single-nucleotide-polymorphism-of-cxcl12-gene-in-breast-cancer-in-pakistan-and-in-silico-expression-analysis-of-cxcl12-cxcr4-associated-biological-regulatory-network
#10
Samra Khalid, Rumeza Hanif
BACKGROUND: C-X-C chemokine ligand 12 (CXCL12) has important implications in breast cancer (BC) pathogenesis. It is selectively expressed on B and T lymphocytes and is involved in hematopoiesis, thymocyte trafficking, stem cell motility, neovascularization, and tumorigenesis. The single nucleotide polymorphism (SNP) rs1801157 of CXCL12 gene has been found to be associated with higher risk of BC. METHODS: Our study focuses on the genotypic and allelic distribution of SNP (rs1801157; G/A) in Pakistani population as well as its association with the clinico-pathological features...
2017: PeerJ
https://www.readbyqxmd.com/read/28927977/the-role-of-pulmonary-metastasectomy-for-hepatoblastoma-in-children-with-metastasis-at-diagnosis-results-from-the-jplt-2-study
#11
Tomoro Hishiki, Kenichiro Watanabe, Kohmei Ida, Ken Hoshino, Tomoko Iehara, Yuki Aoki, Takuro Kazama, Kentaro Kihira, Yuichi Takama, Tomoaki Taguchi, Junya Fujimura, Shohei Honda, Kimikazu Matsumoto, Makiko Mori, Michihiro Yano, Akiko Yokoi, Yukichi Tanaka, Hiroshi Fuji, Osamu Miyazaki, Kenichi Yoshimura, Tetsuya Takimoto, Eiso Hiyama
BACKGROUND/PURPOSE: The purpose of this study was to clarify the role of pulmonary metastasectomy in hepatoblastomas with lung metastasis at diagnosis. We reviewed cases enrolled in the JPLT-2 study. METHODS: A total of 360 cases with hepatoblastoma were enrolled. The clinical courses and outcome of 60 cases with pulmonary metastasis at diagnosis were reviewed, focusing on metastasectomy. RESULTS: Induction chemotherapy resulted in eradication of nodules in 26, residual nodules in 33, and early treatment-related death in one...
September 4, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28927426/the-acid-sensing-ion-channel-asic2-promotes-invasion-and-metastasis-of-colorectal-cancer-under-acidosis-by-activating-the-calcineurin-nfat1-axis
#12
Zhi-Hang Zhou, Jin-Wen Song, Wen Li, Xue Liu, Liu Cao, Lu-Ming Wan, Ying-Xia Tan, Shou-Ping Ji, Yu-Mei Liang, Feng Gong
BACKGROUND: The tumor acidic microenvironment, a common biochemical event in solid tumors, offers evolutional advantage for tumors cells and even enhances their aggressive phenotype. However, little is known about the molecular mechanism underlying the acidic microenvironment-induced invasion and metastasis. METHODS: We examined the expression of the acid-sending ion channel (ASIC) family members after acidic exposure using RT-PCR and immunofluoresence. Gene manipulation was applied to reveal the potential of ASIC2 on invasion, proliferation, colony formation of colorectal cancer (CRC)...
September 19, 2017: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/28927132/downregulation-of-esophageal-cancer-related-gene-4-promotes-proliferation-and-migration-of-hepatocellular-carcinoma
#13
Shujian Ge, Yali Xu, Hongliang Wang, Yaxin Sun, Xiangguo Tian, Zhixin Cao, Xiaoyan Lin, Jiawen Xu, Qiangxiu Wang
Esophageal cancer-related gene 4 (ECRG4) is a candidate tumor suppressor gene, which is involved in cell apoptosis, migration, infection and inflammation responsiveness; however, its expression level and clinical significance in hepatocellular carcinoma (HCC) remains unclear. In the present study, the authors aim to evaluate the clinical significance and potential role of ECRG4 in HCC. Level of ECRG4 protein expression in HCC and peripheral tissues was investigated in tissue specimens obtained from 56 consecutive HCC patients by immunohistochemistry...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28927124/plasma-membrane-expression-of-znf185-is-a-prognostic-factor-in-pancreatic-ductal-carcinoma
#14
Daisuke Furukawa, Tsuyoshi Chijiwa, Masahiro Matsuyama, Masaya Mukai, Ei-Ichi Matsuo, Osamu Nishimura, Kenji Kawai, Hiroshi Suemizu, Toshio Nakagohri, Soji Ozawa, Kazuaki Shimada, Nobuyoshi Hiraoka, Masato Nakamura
Pancreatic ductal carcinoma (PDC) is one of the major causes of cancer-associated mortality globally due to its high potential for distant metastasis. To understand hematogenous metastasis, the molecular expression profiles of weak metastatic PDC cell subline BxPC-3 and highly liver-metastatic cell subline LM-BxPC-3 were compared, and zinc finger protein 185 (ZNF185) was identified as a molecule that is upregulated in LM-BxPC-3 cells. The aim of the present study was to evaluate the clinicopathological significance of ZNF185 in PDC...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28927036/urotensin-ii-receptor-as-a-potential-biomarker-for-the-prognosis-of-hepatocellular-carcinoma-patients
#15
Hongtao Wei, Xiaotong Yu, Xiaowei Xue, Hui Liu, Menglong Wang, Yingying Li, Xuejiang Wang, Huiguo Ding
Urotensin II and the associated urotensin II receptor (UTR) are important in the carcinogenesis of hepatocellular carcinoma (HCC). However, the clinical significance of UTR remains to be elucidated. The aim of the present study was to investigate if UTR exhibits the potential to act as a biomarker to predict the prognosis of HCC patients. The effects of UTR on motility and invasion of HCC cells were additionally investigated. UTR expression levels were determined by immunohistochemistry, in 83 HCC patients that previously underwent curative liver resection...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28927032/clinical-study-of-radiofrequency-ablation-combined-with-tace-in-the-treatment-of-breast-cancer-with-liver-metastasis
#16
Haijun Wang, Bin Liu, Houlong Long, Fengfeng Zhang, Silei Wang, Feng Li
We studied the clinical effects of percutaneous radiofrequency ablation (RFCA) combined with trans-catheter arterial chemoembolization (TACE) in the treatment of breast cancer with liver metastasis. Eighty-eight patients with a diagnosis of breast cancer with liver metastasis for the first time and patients with liver metastasis after radical mastectomy were consecutively selected. The subjects were divided according to the different treatment methods. They were divided either into the control group of 50 cases or the observation group of 38 cases...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28925487/mir-370-functions-as-prognostic-marker-in-patients-with-hepatocellular-carcinoma
#17
X-P Pan, L-H Huang, X Wang
OBJECTIVE: Large body of evidence has shown that microRNAs (miRNAs) have the potential to serve as prognosis marker. This study is designed to investigate the expression of miR-370 in hepatocellular carcinoma (HCC) patients and to analyze its potential prognostic value. PATIENTS AND METHODS: Quantitative real-time quantitative PCR (qPCR) was performed to examine the miR-370 level in HCC tissue and matched normal tissue from 83 HCC patients. The correlation of miR-370 level in HCC tissue with the clinicopathological characteristics was analyzed...
August 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28923109/the-outcome-of-prostate-cancer-patients-treated-with-curative-intent-strongly-depends-on-survival-after-metastatic-progression
#18
Mariarosa Pascale, Che Ngwa Azinwi, Barbara Marongiu, Gianfranco Pesce, Flavio Stoffel, Enrico Roggero
BACKGROUND: Five-year survival in patients with localized prostate cancer (PCa) is nearly 100%, but metastatic disease still remains incurable. Clinical management of metastatic patients has become increasingly complex as novel therapeutic strategies have emerged. This study aims at evaluating the impact of the first metastatic progression on the outcome of PCa patients treated with curative intent. METHODS: The analysis was conducted using data of 913 cases of localized PCa diagnosed between 2000 and 2014...
September 18, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28922441/evaluation-of-2d-shear-wave-elastography-for-characterisation-of-focal-liver-lesions
#19
Ludmila Gerber, Daniel Fitting, Kajana Srikantharajah, Nina Weiler, Georgia Kyriakidou, Joerg Bojunga, Falko Schulze, Dimitra Bon, Stefan Zeuzem, Mireen Friedrich-Rust
BACKGROUND AND AIM: This is a prospective study for evaluation of 2D-shear wave elastography (2D-SWE) for characterisation and differentiation of benign und malignant focal liver lesions (FLLs). METHODS: The patients referred to our ultrasound unit were prospectively included. B-mode ultrasound and 2D-SWE (Aixplorer® France) were performed for one FLL in each patient. Liver histology and/or contrast-enhanced imaging were used as a reference method. RESULTS: 140 patients with FLL were included...
September 2017: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/28919784/durable-complete-remission-of-poor-performance-status-metastatic-lung-adenocarcinoma-patient-treated-with-second-line-erlotinib-a-case-report
#20
Dragana Jovanovic, Ruza Stevic, Marta Velinovic, Milica Kontic, Dragana Maric, Jelena Spasic, Davorin Radosavljevic
This paper presents a rare case of an elderly patient treated with erlotinib for disseminated lung adenocarcinoma with poor performance status (Eastern Cooperative Oncology Group performance status [PS]3). This treatment led to a long duration of complete remission according to Response Evaluation Criteria in Solid Tumors 1.1 - almost 7 years (81 months) of progression-free survival (PFS) and overall survival (OS) of 10 years by March 2017. The treatment with erlotinib started in September 2008 and it was well tolerated with no adverse effects...
2017: OncoTargets and Therapy
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