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https://www.readbyqxmd.com/read/27860212/alcohol-and-dietary-factors-associate-with-gut-integrity-and-inflammation-in-hiv-infected-adults
#1
A R Webel, A Sattar, N T Funderburg, B Kinley, C T Longenecker, D Labbato, Sm Khurshid Alam, G A McComsey
OBJECTIVES: HIV-infected adults have heightened monocyte activation and inflammation, at least partially as a consequence of altered gut integrity. The role of dietary factors in microbial translocation and inflammation and their downstream effect on markers of cardiovascular disease (CVD) have not been explored. Our purpose was to describe the longitudinal dietary patterns of HIV-infected adults, and to examine the relationship between dietary intake, gut integrity, inflammation and subclinical markers of CVD in HIV-infected adults...
November 9, 2016: HIV Medicine
https://www.readbyqxmd.com/read/27647021/incidental-findings-on-chest-computed-tomography-are-common-and-linked-to-inflammation-in-hiv-infected-adults
#2
Michelle S Park, Corrilynn O Hileman, Abdus Sattar, Robert Gilkeson, Grace A McComsey
BACKGROUND: Chest imaging is performed for a variety of reasons in HIV-infected adults. There are limited data on the prevalence of incidental findings, progression of these findings over time and the relationship with inflammation in antiretroviral therapy (ART)-treated HIV-infected adults. METHODS: This study utilized data from a randomized clinical trial of rosuvastatin in HIV-infected adults on ART. Incidental findings were reported from chest computed tomography (CT) scans obtained for coronary artery calcium score at entry, week 48 and 96...
September 20, 2016: Antiviral Therapy
https://www.readbyqxmd.com/read/27631189/pharmacogenomics-of-rosuvastatin-a-glocal-global-local-african-perspective-and-expert-review-on-a-statin-drug
#3
Nyarai D Soko, Collen Masimirembwa, Collet Dandara
The incidence of cardiovascular diseases (CVDs) in African populations residing in the African continent is on the rise fueled by both a steady increase in CVD risk factors and comorbidities such as human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS), tuberculosis, and parasitic diseases such as bilharzia. Statins are recommended together with lifestyle changes in the treatment of hypercholesterolemia and overall reduction of cardiovascular events. Rosuvastatin in particular is an attractive candidate in the management of CVDs in African populations often plagued with multimorbidities owing to both its potency and low drug-to-drug interaction potential...
September 2016: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/27618139/significant-decrease-in-plasma-levels-of-d-dimer-interleukin-8-and-interleukin-12-after-a-12-month-treatment-with-rosuvastatin-in-hiv-infected-patients-under-antiretroviral-therapy
#4
Leonardo Calza, Vincenzo Colangeli, Eleonora Magistrelli, Ilaria Contadini, Isabella Bon, Maria Carla Re, Matteo Conti, Rita Mancini, Pierluigi Viale
OBJECTIVES: Statins have shown anti-inflammatory and immune-modulatory properties in both general and HIV-infected population, but their effect on plasma D-dimer levels is controversial and it has not been investigated to date in HIV-positive patients. The aim of our study was to assess the effect of rosuvastatin on D-dimer and other serum inflammation markers among these subjects. METHODS: Prospective, cohort study of HIV-1-infected adult patients receiving a stable combination antiretroviral therapy (cART), who started a lipid-lowering therapy with rosuvastatin (10 mg daily) and were followed up for at least 12 months...
October 14, 2016: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/27500282/rosuvastatin-decreases-intestinal-fatty-acid-binding-protein-i-fabp-but-does-not-alter-zonulin-or-lipopolysaccharide-binding-protein-lbp-levels-in-hiv-infected-subjects-on-antiretroviral-therapy
#5
Nicholas T Funderburg, Morgan Boucher, Abdus Sattar, Manjusha Kulkarni, Danielle Labbato, Bruce I Kinley, Grace A McComsey
INTRODUCTION: Altered gastrointestinal (GI) barrier integrity and subsequent microbial translocation may contribute to immune activation in HIV infection. We have reported that rosuvastatin improved several markers of immune activation in HIV+ participants, but the effect of statin treatment on markers of GI barrier dysfunction is unknown. METHODS: SATURN-HIV is a randomized, double-blind, placebo-controlled trial assessing the effect of rosuvastatin (10mg/daily) on markers of cardiovascular disease, inflammation, and immune activation in ART-treated patients...
2016: Pathogens & Immunity
https://www.readbyqxmd.com/read/27326658/kallistatin-levels-in-hiv-infected-patients-and-effects-of-statin-therapy
#6
Allison Ross Eckard, Soohee Cho, Mary Ann O'Riordan, Grace A McComsey
BACKGROUND: Kallistatin, a serine proteinase inhibitor, has vasodilatory and anti-inflammatory properties and is increased in other inflammatory conditions. We measured kallistatin in HIV for the first time, examined its relationship with inflammation, and determined if statin therapy affected levels. METHODS: Kallistatin levels were measured in subjects from a randomized, double-blinded, placebo-controlled trial. RESULTS: 135 HIV-infected subjects were included...
June 21, 2016: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/27294339/effect-of-rosuvastatin-on-plasma-coenzyme-q10-in-hiv-infected-individuals-on-antiretroviral-therapy
#7
Justin T Morrison, Chris T Longenecker, Alison Mittelsteadt, Ying Jiang, Sara M Debanne, Grace A McComsey
BACKGROUND: Coenzyme Q10 (CoQ10) deficiency has been associated with statin-induced myopathy, and supplementation with CoQ10 may reduce inflammation markers. The effects of statins on CoQ10 and its anti-inflammatory properties have not been investigated in HIV-positive patients. OBJECTIVE: The objectives of this study were to examine the effect of rosuvastatin on CoQ10 and CoQ10/LDL ratio over 24-week SATURN-HIV trial, explore the associations between CoQ10 levels and markers of vascular disease, inflammation, and immune activation, and assess whether changes in CoQ10 affected the anti-inflammatory effects of statin therapy or were associated with myalgia symptoms...
July 2016: HIV Clinical Trials
https://www.readbyqxmd.com/read/27203715/rosuvastatin-slows-progression-of-subclinical-atherosclerosis-in-patients-with-treated-hiv-infection
#8
Chris T Longenecker, Abdus Sattar, Robert Gilkeson, Grace A McComsey
OBJECTIVE: To determine the effect of statins on the progression of subclinical atherosclerosis in a population of HIV-infected adults on antiretroviral therapy. DESIGN: Double-blind, randomized clinical trial. METHODS: Stopping Atherosclerosis and Treating Unhealthy Bone with RosuvastatiN in HIV infection was a 96-week double-blind, randomized clinical trial of 10 mg daily rosuvastatin (n = 72) vs. placebo (n = 75) in a population of HIV-infected subjects on stable antiretroviral therapy with LDL-cholesterol 130 mg/dl or less (≤3...
September 10, 2016: AIDS
https://www.readbyqxmd.com/read/27192322/drug-therapies-for-hiv-related-metabolic-disorders
#9
Karuna Lamarca, Ana García Sarasola, Francesc Vidal, Pere Domingo
INTRODUCTION: Human immunodeficiency virus (HIV) has become a chronic disease often associated with dyslipidaemia and insulin resistance. Combination antiretroviral therapy (cART) may contribute to metabolic disturbances, eventually leading to increased cardiovascular disease (CVR) in this population. Escalating interventions to decrease CVR include promoting a healthy lifestyle, such as quitting smoking, diet and regular exercise. If they do not achieve the goals, a change of cART should be considered, followed by or used concomitantly with the use of chemical therapies...
July 2016: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/26987376/rosuvastatin-vs-protease-inhibitor-switching-for-hypercholesterolaemia-a-randomized-trial
#10
F J Lee, P Monteiro, D Baker, M Bloch, N Roth, R Finlayson, R Moore, J Hoy, E Martinez, A Carr
OBJECTIVES: The aim of the study was to compare the efficacy and safety of rosuvastatin initiation with those of switching of ritonavir-boosted protease inhibitors (PI/rs) in HIV-1-infected adults with hypercholesterolaemia and increased cardiovascular risk scores. METHODS: In this open-label, multicentre study, HIV-1-infected adults on PI/r-based therapy with viral load < 50 HIV-1 RNA copies/mL, fasting total cholesterol ≥ 5.5 mmol/L (both for ≥ 6 months) and elevated cardiovascular risk (Framingham score ≥ 8% or diabetes or family history), and not on lipid-lowering therapy, were randomized to open-label rosuvastatin 10 mg/day or to PI/r switching, both with standardized diet/exercise advice...
September 2016: HIV Medicine
https://www.readbyqxmd.com/read/26851703/comparative-safety-and-efficacy-of-statins-for-primary-prevention-in-human-immunodeficiency-virus-positive-patients-a-systematic-review-and-meta-analysis
#11
Sebastiano Gili, Walter Grosso Marra, Fabrizio D'Ascenzo, Enrica Lonni, Andrea Calcagno, Margherita Cannillo, Flavia Ballocca, Enrico Cerrato, Martina Pianelli, Umberto Barbero, Massimo Mancone, James J DiNicolantonio, Carl J Lavie, Pierluigi Omedè, Antonio Montefusco, Stefano Bonora, Mauro Gasparini, Giuseppe Biondi-Zoccai, Claudio Moretti, Fiorenzo Gaita
The efficacy and safety of different statins for human immunodeficiency virus (HIV)-positive patients in the primary prevention setting remain to be established. In the present meta-analysis, 18 studies with 736 HIV-positive patients receiving combination antiretroviral therapy (cART) and treated with statins in the primary prevention setting were included (21.0% women, median age 44.1 years old). The primary endpoint was the effect of statin therapy on total cholesterol (TC) levels. Rosuvastatin 10 mg and atorvastatin 10 mg provided the largest reduction in TC levels [mean -1...
February 6, 2016: European Heart Journal
https://www.readbyqxmd.com/read/26835476/the-effect-of-rosuvastatin-on-markers-of-immune-activation-in-treatment-naive-human-immunodeficiency-virus-patients
#12
Robyn G M Weijma, Eric R A Vos, Jaap Ten Oever, Muriel Van Schilfgaarde, Lea M Dijksman, André Van Der Ven, Guido E L Van Den Berk, Kees Brinkman, Jos P H J Frissen, Anja Leyte, Ineke W E M Schouten, Mihai G Netea, Willem L Blok
Background.  Immune activation has been implicated in the excess mortality in human immunodeficiency virus (HIV)-infected patients, due to cardiovascular diseases and malignancies. Statins may modulate this immune activation. We assessed the capacity of rosuvastatin to mitigate immune activation in treatment-naive HIV-infected patients. Methods.  In a randomized double-blind placebo-controlled crossover study, we explored the effects of 8 weeks of rosuvastatin 20 mg in treatment-naive male HIV-infected patients (n = 28) on immune activation markers: neopterin, soluble Toll-like receptor (TLR)2, sTLR4, interleukin (IL)-6, IL-1Ra, IL-18, d-dimer, highly sensitive C-reactive protein, and CD38 and/or human leukocyte antigen-DR expression on T cells...
January 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/26731754/changes-in-oxidized-lipids-drive-the-improvement-in-monocyte-activation-and-vascular-disease-after-statin-therapy-in-hiv
#13
RANDOMIZED CONTROLLED TRIAL
Corrilynn O Hileman, Randi Turner, Nicholas T Funderburg, Richard D Semba, Grace A McComsey
BACKGROUND: Oxidative stress plays a significant role in atherosclerosis development. HIV infection has been linked with heightened cardiovascular disease risk. HMG-CoA reductase inhibitors may reduce oxidative stress and subsequently subclinical vascular disease in HIV. DESIGN/METHODS: This is a randomized, placebo-controlled trial to evaluate the effect of rosuvastatin in HIV-infected adults on stable antiretroviral therapy with low-density lipoprotein less than 130  mg/dl and increased inflammation or T-cell activation on subclinical vascular disease...
January 2, 2016: AIDS
https://www.readbyqxmd.com/read/26658651/statins-to-improve-cardiovascular-outcomes-in-treated-hiv-infection
#14
REVIEW
Chris T Longenecker, Allison R Eckard, Grace A McComsey
PURPOSE OF REVIEW: To evaluate evidence that statins reduce cardiovascular risk in patients living with HIV. RECENT FINDINGS: Moderate to high-dose atorvastatin and rosuvastatin appear to reduce noncalcified coronary plaque volume and slow progression of carotid intima-media thickness in patients with treated HIV infection. Expected lipoprotein changes with statins on the background of modern antiretroviral therapy are similar to the general population. In addition to lipids, the statin benefit may be mediated in part by improvements in vascular inflammation and levels of T-cell and monocyte activation...
February 2016: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/26536319/rosuvastatin-is-effective-to-decrease-cd8-t-cell-activation-only-in-hiv-infected-patients-with-high-residual-t-cell-activation-under-antiretroviral-therapy
#15
Laurence Weiss, Mathieu F Chevalier, Lambert Assoumou, Jean-Louis Paul, Martine Alhenc-Gelas, Céline Didier, Saïd Taibi, Elena-Maria Manea, Pauline Campa, Pierre-Marie Girard, Dominique Costagliola
OBJECTIVE: The aim of the trial was to evaluate in patients under antiretroviral therapy (ART) the effect of rosuvastatin on cellular and soluble markers of immune activation/inflammation, as well as to identify patients who better benefit from statin administration. METHODS: IMEA-043-CESAR was a phase II open-label pilot trial that enrolled patients under suppressive ART and CD4 <500/mm. Patients received rosuvastatin (20 mg/d) for 12 weeks. The primary outcome was the variation at week 12 (W12) in the proportion of CD38HLA-DRCD8 T lymphocytes...
April 1, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/26477698/effects-of-96-weeks-of-rosuvastatin-on-bone-muscle-and-fat-in-hiv-infected-adults-on-effective-antiretroviral-therapy
#16
Kristine M Erlandson, Ying Jiang, Sara M Debanne, Grace A McComsey
Heightened inflammation and immune activation are associated with lower bone mineral density (BMD) and lean body mass (LBM) among HIV-infected persons. We hypothesized that a reduction in inflammation with rosuvastatin would be associated with improvements in BMD and LBM. HIV-infected participants on stable antiretroviral therapy without statin indication and with heightened immune activation (≥19% CD8(+)CD38(+)HLA-DR(+) T cells) or inflammation (hsCRP ≥2 mg/liter) were randomized to rosuvastatin 10 mg daily or placebo for 96 weeks...
April 2016: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/26455521/the-effect-of-physical-activity-on-cardiometabolic-health-and-inflammation-in-treated-hiv-infection
#17
Sahera Dirajlal-Fargo, Allison R Webel, Chris T Longenecker, Bruce Kinley, Danielle Labbato, Abdus Sattar, Grace A McComsey
BACKGROUND: In HIV-uninfected populations, physical activity decreases mortality and inflammation. Inflammation is a potential cause of comorbidities in HIV+ adults, the evidence examining the effect of physical activity on cardiometabolic health is limited. This analysis examines the relationship between physical activity, cardiometabolic health and inflammation. METHODS: We conducted a nested study within the SATURN-HIV trial in which 147 HIV+ adults were randomized to 10 mg daily rosuvastatin or placebo...
2016: Antiviral Therapy
https://www.readbyqxmd.com/read/26372274/hiv-vasculopathy-role-of-mononuclear-cell-associated-kr%C3%A3-ppel-like-factors-2-and-4
#18
RANDOMIZED CONTROLLED TRIAL
Andrew T Hale, Chris T Longenecker, Ying Jiang, Sara M Debanne, Danielle E Labatto, Norma Storer, Anne Hamik, Grace A McComsey
OBJECTIVE: To determine the relationships between Krüppel-like factors (KLF) 2 and 4, immune-activation, and subclinical vascular disease in HIV-infected patients on antiretroviral therapy (ART). DESIGN: Double-blind, randomized, placebo-controlled trial. METHODS: We studied 74 HIV-infected adults on ART enrolled in a randomized clinical trial of statin therapy. KLF2 and KLF4 gene expression was measured by quantitative PCR from peripheral blood mononuclear cells (PBMCs) at baseline and after 24 weeks of 10 mg daily rosuvastatin or placebo...
August 24, 2015: AIDS
https://www.readbyqxmd.com/read/26269240/plasma-selenium-concentrations-are-sufficient-and-associated-with-protease-inhibitor-use-in-treated-hiv-infected-adults
#19
RANDOMIZED CONTROLLED TRIAL
Corrilynn O Hileman, Sahera Dirajlal-Fargo, Suet Kam Lam, Jessica Kumar, Craig Lacher, Gerald F Combs, Grace A McComsey
BACKGROUND: Selenium is an essential constituent of selenoproteins, which play a substantial role in antioxidant defense and inflammatory cascades. Selenium deficiency is associated with disease states characterized by inflammation, including cardiovascular disease (CVD). Although HIV infection has been associated with low selenium, the role of selenium status in HIV-related CVD is unclear. OBJECTIVES: We sought to assess associations between plasma selenium and markers of inflammation, immune activation, and subclinical vascular disease in HIV-infected adults on contemporary antiretroviral therapy (ART) and to determine if statin therapy modifies selenium status...
October 2015: Journal of Nutrition
https://www.readbyqxmd.com/read/26157049/rosuvastatin-worsens-insulin-resistance-in-hiv-infected-adults-on-antiretroviral-therapy
#20
RANDOMIZED CONTROLLED TRIAL
Kristine M Erlandson, Ying Jiang, Sara M Debanne, Grace A McComsey
BACKGROUND: Statins are associated with increased diabetes risk in large, human immunodeficiency virus (HIV)-uninfected cohorts; the impact of statins on insulin resistance or diabetes in HIV-infected persons has not been assessed within a randomized controlled study. METHODS: HIV-infected participants on stable antiretroviral therapy with a low-density lipoprotein cholesterol level of ≤130 mg/dL and heightened immune activation or inflammation were randomized to rosuvastatin 10 mg daily or placebo for 96 weeks...
November 15, 2015: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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