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HIV testosterone

Ronni Hayon
Transgender and gender-nonconforming individuals experience significant health disparities. They are more likely to use drugs and alcohol, smoke, be diagnosed with HIV infection or other sexually transmitted infections, and experience depression or attempt suicide. Many also experience discrimination within the health care system. Office-level strategies to create a safe and affirming space for gender-expansive patients include posting of a nondiscrimination statement, use of intake forms that ask about current gender identity and birth-assigned sex, provision of gender-neutral restrooms, and staff training in use of appropriate language...
October 2016: FP Essentials
Rand Dadasovich, Coco Auerswald, Alexandra M Minnis, H Fisher Raymond, Willi McFarland, Erin C Wilson
Little research has explored the link between the behavioural effects of testosterone use among transmen and HIV risk. We conducted a mixed methods study to explore testosterone use among transmen and the behavioural effects on HIV risk. A sample of 122 transmen from San Francisco participated in a cross-sectional quantitative survey and 14 transmen participated in 2 focus group discussions. Most participants (81.9%) were currently taking hormones. Participants attributed testosterone use to new sexual behaviours among 69% of transmen, changes in sexual attraction (49%), and increased frequency of sexual activity (72%)...
August 24, 2016: Culture, Health & Sexuality
Andrew J Chetwynd, Amanda Samarawickrama, Jaime H Vera, Stephen A Bremner, Alaa Abdul-Sada, Yvonne Gilleece, Stephen G Holt, Elizabeth M Hill
BACKGROUND: The use of combination antiretroviral therapy (cART) has substantially improved the outlook for patients with HIV infection. However, lifelong exposure to cART is also associated with adverse metabolic changes and an enhanced risk of renal, hepatic and cardiovascular dysfunction. This study investigated disruptions of the urinary metabolome of cART-exposed patients, thereby furthering our understanding of some of the side effects of pharmaceutical intervention. METHODS: HIV-positive patients were recruited from an HIV clinic and divided into cART-naïve and cART-exposed groups...
August 16, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Miguel A Lopez-Ruz, Purificación Navas, Miguel A López-Zúñiga, María Carmen Gonzalvo, Antonio Sampedro, Juan Pasquau, Carmen Hidalgo-Tenorio, Rosario Javier, José A Castilla
Patients with human immunodeficiency virus type 1 (HIV-1) who receive antiretroviral therapy (ART) often achieve increased survival and improved quality of life. In this respect, monotherapy with darunavir/ritonavir (mDRV/r) can be a useful treatment strategy. This prospective study analyses the effect of mDRV/r on sperm quality and viral load in a group of 28 patients who had previously been given conventional ART and who had recorded a viral load <20 copies/mL for at least six months. These patients were given mDRV/r at a dose of 800/100 mg for 48 weeks...
2016: PloS One
Bhanukumar Muthiah, Abithraj Kallikadavil, Rajendraprasad Shivaswamy, Vineetha Bharathan Menon
INTRODUCTION: Every endocrine gland has been reported to be affected at varying rates in HIV. HIV is a highly stigmatized chronic disease with a substantial co-occurrence of mental and sexual health problems; however the sexual health problems in women have not been extensively studied. AIM: To study the gonadal hormonal abnormalities and sexual dysfunction in HIV positive female patients and its possible association. MATERIALS AND METHODS: This descriptive/exploratory study was conducted in the Department of General Medicine at a tertiary care hospital from September 2013 to August 2015...
April 2016: Journal of Clinical and Diagnostic Research: JCDR
Melissa E Badowski, Sarah E Perez
Since the beginning of the HIV/AIDS epidemic, weight loss has been a common complaint for patients. The use of various definitions defining HIV wasting syndrome has made it difficult to determine its actual prevalence. Despite the use of highly active antiretroviral therapy, it is estimated that the prevalence of HIV wasting syndrome is between 14% and 38%. HIV wasting syndrome may stem from conditions affecting chewing, swallowing, or gastrointestinal motility, neurologic disease affecting food intake or the perception of hunger or ability to eat, psychiatric illness, food insecurity generated from psychosocial or economic concerns, or anorexia due to medications, malabsorption, infections, or tumors...
2016: HIV/AIDS: Research and Palliative Care
Leah Shepherd, Álvaro H Borges, Lene Ravn, Richard Harvey, Mark Bower, Andrew Grulich, Michael Silverberg, Gitte Kronborg, Massimo Galli, Ole Kirk, Jens Lundgren, Amanda Mocroft
BACKGROUND: It is common practice to use PSA≥4.0 µg/L as a clinical indicator for men at risk of PCa, however this is unverified in HIV + men. We aimed to describe kinetics and predictive value of PSA for prostate-cancer (PCa) in HIV+ men. METHODS: A nested-case-control study of 21 men with PCa and 40 matched-controls within EuroSIDA was conducted. Prospectively stored plasma samples before PCa (or matched date in controls) were measured for the following markers: Total PSA[tPSA], free PSA[fPSA], testosterone and sex hormone binding globulin[SHB]...
January 29, 2016: Antiviral Therapy
Laurence Slama, Lisa P Jacobson, Xiuhong Li, Frank J Palella, Joseph B Margolick, Lawrence A Kingsley, Dorothy J Wiley, Gilles Pialoux, Adrian S Dobs, Todd T Brown
BACKGROUND: Aging in males is associated with lower testosterone levels and a decrease in diurnal variation of testosterone secretion. Cross-sectional studies have shown lower than expected testosterone levels among HIV-infected men, but whether age-related changes in serum testosterone differ by HIV serostatus are not known. METHODS: HIV-infected men from the Multicenter AIDS Cohort Study (MACS), age ≥ 45 years at highly active antiretroviral therapy initiation, who had ≥ 2 samples from the subsequent 10 years, were matched to HIV-uninfected men by age, race, MACS site, and calendar time of samples...
January 1, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Noppadol Kietsiriroje
Hypogonadism is a common complication among HIV infected patients. The prevalence of hypogonadism is 30 to 50% in HIV infected men with wasting syndrome and 20 to 25% in those without wasting syndrome. HIV infection affects the entire hypothalamus-pituitary-gonadal axis via both direct and indirect effects, which are defined in four categories, 1) direct effect of HIV particles, 2) opportunistic infections, 3) HIV-related malignancy and its treatment, and 4) medications that are used for HIV infection or its opportunistic infection...
October 2015: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
Roger Bedimo, James Cutrell, Song Zhang, Henning Drechsler, Ang Gao, Geri Brown, Irfan Farukhi, Rosinda Castanon, Pablo Tebas, Naim M Maalouf
OBJECTIVE: Both HIV and hepatitis C virus (HCV) infections are associated with higher osteoporotic fracture risk. Increased bone turnover, liver fibrosis, tenofovir (TDF) use or hormonal imbalances are possible underlying mechanisms. DESIGN: This prospective, cross-sectional study assessed 298 male volunteers with either virologically suppressed HIV or untreated HCV mono-infections, HIV/HCV co-infection and noninfected controls. METHODOLOGY: Study participants underwent bone mineral density (BMD) by dual-energy x-ray absorptiometry and measurement of bone turnover markers [BTM: C-telopeptide (CTX) and osteocalcin (OC)], insulin-like growth factor-1 (IGF-1), the sex steroids testosterone (T) and estradiol (E2), and the aspartate aminotransferase-to-platelet ratio index (APRI)...
February 20, 2016: AIDS
D Santi, B Madeo, F Carli, S Zona, G Brigante, F Vescini, G Guaraldi, V Rochira
SUMMARY: By investigating the relationship between serum testosterone, estradiol, and bone mineral density (BMD) in a large cohort of HIV-infected men, estradiol was associated with BMD, relative estrogen deficiency being involved in bone loss in men with hypogonadism, in addition to all HIV-related factors. Increased aromatization in adipose tissue does not counteract HIV-related bone loss. INTRODUCTION: The purpose of this study is to evaluate the relationship between serum testosterone, estradiol, and BMD in a large cohort of HIV-infected men...
March 2016: Osteoporosis International
Yoshihiko Shimokawa, Noriaki Yoda, Satoshi Kondo, Yoshiya Yamamura, Yoshiharu Takiguchi, Ken Umehara
The direct inhibitory potential of twenty five anti-tuberculosis drugs on eight CYP-specific reactions in human liver microsomes was investigated to predict in vivo drug-drug interactions (DDIs) from in vitro data. Rifampicin, rifabutin, and thioacetazone inhibited one CYP reaction. Isoniazid and clofazimine had inhibitory effects on four CYP reactions, and rifapentine, ethionamide, and prothionamide widely inhibited CYP reactions. Based on the inhibition constant (Ki) and the therapeutic total inhibitor concentrations [I]max of eight drugs in human plasma, [I]max/Ki values were calculated to evaluate clinical DDIs...
2015: Biological & Pharmaceutical Bulletin
C Frapsauce, S Grabar, M Leruez-Ville, O Launay, P Sogni, V Gayet, J P Viard, M De Almeida, P Jouannet, E Dulioust
STUDY QUESTION: Are antiretroviral therapies associated with semen alterations in HIV-infected men? SUMMARY ANSWER: Antiretroviral regimens that included the non-nucleosidic reverse transcriptase inhibitor efavirenz were associated with a significant impairment of sperm motility, whereas regimens without efavirenz were not associated with significant semen changes. WHAT IS KNOWN ALREADY: Semen alterations including decreased ejaculate volume and sperm motility have been reported in HIV-infected men...
August 2015: Human Reproduction
Nicole G Jaff, Shane A Norris, Tracy Snyman, Marketa Toman, Nigel J Crowther
OBJECTIVES: Little data are available for sub-Saharan African women on changes in body composition in menopause transition (MT). The study aimed to determine whether there are differences in body adiposity, lean muscle mass, and bone mineral density (BMD) across MT groups in urban African women, who have a high prevalence of obesity and HIV infection, and if this is related to an altered hormonal milieu. DESIGN: Participants were 702 black urban women. Menopause stage was defined using STRAW+10 criteria...
September 2015: Metabolism: Clinical and Experimental
Martin Mücke, Henning Cuhls, Vera Peuckmann-Post, Ollie Minton, Patrick Stone, Lukas Radbruch
BACKGROUND: This review updates the original review, 'Pharmacological treatments for fatigue associated with palliative care' and also incorporates the review 'Drug therapy for the management of cancer-related fatigue'.In healthy individuals, fatigue is a protective response to physical or mental stress, often relieved by rest. By contrast, in palliative care patients' fatigue can be severely debilitating and is often not counteracted with rest, thereby impacting daily activity and quality of life...
2015: Cochrane Database of Systematic Reviews
Christopher J Mulder, Ryan S Cho, Stephen A Harrison, Katherine Cebe, James M Francis
BACKGROUND: Giant cell hepatitis is a rare entity in adults, accounting for 0.1% to 0.25% of liver disease in adults. Postinfantile giant cell hepatitis is often characterized by multinucleated giant cells on liver biopsy and a fulminant hepatitis. CASE REPORT: An active duty 36-year-old African-American male deployed to Kabul, Afghanistan, presented with jaundice 2 weeks after starting a testosterone analogue. He discontinued the supplement, but his jaundice persisted with up-trending bilirubin...
May 2015: Military Medicine
Frank Q Nuttall, Rohit S Warrier, Mary C Gannon
PURPOSE: A large number of medications have been implicated in the genesis of gynecomastia. However, gynecomastia is common in men, asymptomatic, increases with age, and is considered to be due to an increased estradiol/testosterone ratio. This complicates the interpretation of medication-related gynecomastia. Therefore, we have reviewed the literature in order to assess the data relating gynecomastia onset with utilization of specific medications. METHODS: The literature was searched in PubMed and the Ovid/Medline databases from the 1946 to January 2015 with the search terminology of "gynecomastia, drugs/medications...
May 2015: European Journal of Clinical Pharmacology
Hilary K Hsu, Todd T Brown, Xiuhong Li, Stephen Young, Ross D Cranston, Gypsyamber D'Souza, Lisa P Jacobson, Otoniel Martínez-Maza, Eric C Seaberg, Joseph B Margolick, Frank J Jenkins, Matthew G Moran, Kristofer Chua, Robert K Bolan, Roger Detels, Dorothy J Wiley
BACKGROUND: Human papillomavirus (HPV) types 16 and 18 cause invasive cervical cancer and most invasive anal cancers (IACs). Overall, IAC rates are highest among men who have sex with men (MSM), especially MSM with HIV infection. Testosterone is prescribed for men showing hypogonadism and HIV-related wasting. While there are direct and indirect physiological effects of testosterone in males, its role in anal HPV16/18 infections in men is unknown. METHODS: Free testosterone (FT) was measured in serum from 340 Multicenter AIDS Cohort Study (MACS) participants who were tested for anal HPV16/18-DNA approximately 36 months later...
2015: PloS One
V Rochira, C Diazzi, D Santi, G Brigante, A Ansaloni, M C Decaroli, S De Vincentis, C Stentarelli, S Zona, G Guaraldi
Men with human immunodeficiency virus (HIV) infection are often hypogonadal and develop several HIV-associated non-acquired immunodeficiency syndrome (AIDS) (HANA) conditions that impair overall health status. No studies explored the relationship between health status and serum testosterone (T) in HIV-infected men. This study aims to investigate the association between total serum T and HANA, multimorbidity, and frailty in a large cohort of 1359 HIV-infected men and to explore the relationship between patients' overall health status and serum T...
March 2015: Andrology
Sujit Kumar Tripathy, Ritesh Kumar Agrawala, Anoj Kumar Baliarsinha
AIMS AND OBJECTIVES: To study the frequency of thyroid, adrenal and gonadal dysfunction in newly diagnosed HIV-infected patients and to correlate them at different levels of CD4 cell counts. MATERIALS AND METHODS: Forty-three HIV-positive cases were included in the study group. Cases were divided into three groups on the basis of CD4 cell count. Serum free T3, free T4, TSH, Cortisol, FSH, LH, testosterone and estradiol were estimated by the radioimmunoassay method...
January 2015: Indian Journal of Endocrinology and Metabolism
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