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https://www.readbyqxmd.com/read/28378852/effects-of-non-nutritive-artificial-vs-natural-sweeteners-on-24-h-glucose-profiles
#1
S L Tey, N B Salleh, C J Henry, C G Forde
Replacing nutritive sweetener with non-nutritive sweeteners (NNS) has the potential to improve glycaemic control. The objective of this study was to investigate the effects of consuming artificial NNS (that is, aspartame), natural NNS (that is, monk fruit and stevia), and sucrose-sweetened beverages on 24-h glucose profiles. Ten healthy males took part in this randomised, crossover study with the following four treatments: aspartame-, monk fruit-, stevia-, and sucrose- (65 g) sweetened beverages. Participants were asked to consume the test beverage as a preload mid-morning...
April 5, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28375037/the-influence-of-stevia-on-the-flow-shear-and-compression-behavior-of-sorbitol-a-pharmaceutical-excipient-for-direct-compression
#2
Hana Hurychová, Pavel Ondrejček, Zdenka Šklubalová, Barbora Vraníková, Tomáš Svěrák
Good flow and compaction properties are necessary for manipulation of particulate material in the pharmaceutical industry. The influence of the addition of an alternative sweetener, rebaudioside A, in a concentration 0.2% w/w and 0.5% w/w on the flow, shear and compaction properties of sorbitol for direct compaction, Merisorb® 200, was investigated in this work. Rebaudioside A worsened the flow properties of sorbitol: the Hausner ratio, the compressibility index and the mass flow rate through the aperture of a model hopper...
April 4, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/28372222/effect-of-sweetener-combination-and-storage-temperature-on-physicochemical-properties-of-sucrose-free-white-chocolate
#3
Laura T Rodriguez Furlán, Yanina Baracco, Javier Lecot, Noemi Zaritzky, Mercedes E Campderrós
The influence of a combination of sweeteners (Stevia (St) and sucralose (Su)) and storage temperature on thermal properties, microstructure, water content, texture and Bloom of sucrose free white chocolate was investigated. A strong relationship between the microstructure and the highest percentage of Bloom was observed. The samples with 100%Su and 50%S+50%Su presented microstructures with channels through which solids and fat could more easily spread to the surface, increasing the fat and sugar Bloom formation...
August 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28372164/optimization-of-microwave-assisted-extraction-of-total-extract-stevioside-and-rebaudioside-a-from-stevia-rebaudiana-bertoni-leaves-using-response-surface-methodology-rsm-and-artificial-neural-network-ann-modelling
#4
Kashif Ameer, Seong-Woo Bae, Yunhee Jo, Hyun-Gyu Lee, Asif Ameer, Joong-Ho Kwon
Stevia rebaudiana (Bertoni) consists of stevioside and rebaudioside-A (Reb-A). We compared response surface methodology (RSM) and artificial neural network (ANN) modelling for their estimation and predictive capabilities in building effective models with maximum responses. A 5-level 3-factor central composite design was used to optimize microwave-assisted extraction (MAE) to obtain maximum yield of target responses as a function of extraction time (X1: 1-5min), ethanol concentration, (X2: 0-100%) and microwave power (X3: 40-200W)...
August 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28364791/effect-of-nitrogen-sources-on-some-morphological-characteristics-of-in-vitro-stevia-rebaudiana-bertoni
#5
F Akbari, A Arminian, D Kahrizi, A Fazeli
Stevia rebaudiana Bertoni belongs to Asteraceae family that leaves 200-300 times sweeter than sugar. Low seed fertility is one of the most important problems in Stevia production. So, Plant tissue culture is an efficient method for mass propagation of Stevia. In this research, we studied the effect of various concentrations of nitrogen on some morphological traits of stevia under in vitro conditions. We used axillary nodes as explants and they were cultured on Murashige and Skoog (MS) medium containing inorganic nitrogen sources i...
February 28, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28363166/insight-into-anti-diabetic-effect-of-low-dose-of-stevioside
#6
Vladimirka Ilić, Saša Vukmirović, Nebojša Stilinović, Ivan Čapo, Milan Arsenović, Boris Milijašević
Diabetes mellitus is a chronic disease characterized by abnormal carbohydrate, lipid and protein metabolism due to a lack of insulin or reduced target cell sensitivity to insulin. Stevia rebaudiana is an important source of biochemically active substances with proven anti-diabetic effect. The aim of this study was to determine anti-diabetic effects of the low dose of stevioside in NMRI Haan mice. Aqueous stevioside solution (20mg/kg body weight) was administered by oral route of administration. Anti-diabetic effect of stevioside was estimated by oral glucose tolerance test, adrenaline test after a 10day stevioside treatment, and alloxan induced hyperglycaemia in mice (two experimental groups, 10day stevioside treatment before and after alloxan administration)...
March 28, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28361903/steviol-glycosides-enhance-pancreatic-beta-cell-function-and-taste-sensation-by-potentiation-of-trpm5-channel-activity
#7
Koenraad Philippaert, Andy Pironet, Margot Mesuere, William Sones, Laura Vermeiren, Sara Kerselaers, Sílvia Pinto, Andrei Segal, Nancy Antoine, Conny Gysemans, Jos Laureys, Katleen Lemaire, Patrick Gilon, Eva Cuypers, Jan Tytgat, Chantal Mathieu, Frans Schuit, Patrik Rorsman, Karel Talavera, Thomas Voets, Rudi Vennekens
Steviol glycosides (SGs), such as stevioside and rebaudioside A, are natural, non-caloric sweet-tasting organic molecules, present in extracts of the scrub plant Stevia rebaudiana, which are widely used as sweeteners in consumer foods and beverages. TRPM5 is a Ca(2+)-activated cation channel expressed in type II taste receptor cells and pancreatic β-cells. Here we show that stevioside, rebaudioside A and their aglycon steviol potentiate the activity of TRPM5. We find that SGs potentiate perception of bitter, sweet and umami taste, and enhance glucose-induced insulin secretion in a Trpm5-dependent manner...
March 31, 2017: Nature Communications
https://www.readbyqxmd.com/read/28358484/structure-determination-and-mechanism-of-formation-of-a-seco-moreliane-derivative-supported-by-computational-analysis
#8
Pablo A Chacón Morales, Juan M Amaro-Luis, Andrei G Kutateladze
Basic hydrolysis of a dichloromethane extract of Stevia lucida yielded (4R,5S,7R,9R,10R,11R)-7,9-dihydroxylongipin-2-en-1-one (1), which was oxidized and subjected to acidic conditions to generate the new seco-moreliane derivative 3. The structure of 3 was established based on NMR data interpretation and confirmed computationally. A plausible mechanism for the carbocationic rearrangement of the trione 2 to the seco-moreliane 3 was supported by DFT computations.
March 30, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28351677/toxicological-evaluation-of-ethanolic-extract-from-stevia-rebaudiana-bertoni-leaves-genotoxicity-and-subchronic-oral-toxicity
#9
Qiannan Zhang, Hui Yang, Yongning Li, Haibo Liu, Xudong Jia
Stevia rebaudiana Bertoni leaves have a long history of use as an abundant source of sweetener. The aqueous extract of stevia leaves and the predominant constitutes steviol glycosides have been intensively investigated. However, rare studies provided toxicological evaluation of bioactive components in the polar extract regarding their safety on human health. This study aimed to evaluate the toxicity of ethanolic extract of Stevia rebaudiana Bertoni leaves through a battery of in vitro and in vivo tests. Negative results were unanimously obtained from bacterial reverse mutation assay, mouse bone marrow micronucleus assay and mouse sperm malformation assay...
March 25, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28346877/stevia-rebaudiana-bertoni-effect-on-the-hemolytic-potential-of-listeria-monocytogenes
#10
S Sansano, A Rivas, M C Pina-Pérez, A Martinez, D Rodrigo
The effect of Stevia rebaudiana Bertoni on the hemolytic potential of Listeria monocytogenes was studied by means of the assessment of the Listeriolysin O (LLO) production. The three factors under study, stevia concentration in the range [0-2.5] % (w/v), incubation temperature (10 and 37°C), and exposure time (0-65h) significantly affected (p≤0.05) the hemolytic activity of L. monocytogenes. Results showed that at the lower incubation temperature the hemolytic potential of the bacterium was significantly reduced, from 100% at 37°C to 8% at 10°C (after 65h of incubation) in unsupplemented substrate (0% stevia)...
March 16, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28343388/development-and-validation-of-an-enzymatic-method-to-determine-stevioside-content-from-stevia-rebaudiana
#11
Somsiri Udompaisarn, Dumrongkiet Arthan, Jamorn Somana
An enzymatic method for specific determination of stevioside content was established. Recombinant β-glucosidase BT_3567 (rBT_3567) from Bacteroides thetaiotaomicron HB-13 exhibited selective hydrolysis of stevioside at β-1,2-glycosidic bond to yield rubusoside and glucose. Coupling of this enzyme with glucose oxidase and peroxidase allowed for quantitation of stevioside content in Stevia samples by using a colorimetric-based approach. The series of reactions for stevioside determination can be completed within 1 h at 37 °C...
April 6, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28334357/sweetener-intake-by-rats-selectively-bred-for-differential-saccharin-intake-sucralose-stevia-and-acesulfame-potassium
#12
Nancy K Dess, Kiana Dobson, Brandon T Roberts, Clinton D Chapman
Behavioral responses to sweeteners have been used to study the evolution, mechanisms, and functions of taste. Occidental low and high saccharin consuming rats (respectively, LoS and HiS) have been selectively outbred on the basis of saccharin intake and are a valuable tool for studying variation among individuals in sweetener intake and its correlates. Relative to HiS rats, LoS rats consume smaller amounts of all nutritive and nonnutritive sweeteners tested to date, except aspartame. The lines also differ in intake of the commercial product Splenda; the roles of sucralose and saccharides in the difference are unclear...
March 15, 2017: Chemical Senses
https://www.readbyqxmd.com/read/28278673/development-of-an-efficient-high-performance-thin-layer-chromatography-method-for-determination-of-jasmonic-acid-in-leaf-tissue-of-stevia-rebaudiana-bertoni-bertoni
#13
Divya Kilam, M Saifi, A Agnihotri, M Z Abdin
Determination of endogenous levels of jasmonic acid (JA) is essential, as it plays a pivotal role in the physiological processes during a plant's life cycle. A high performance thin layer chromatography (HPTLC) method was developed for the detection and quantification of JA in leaf extracts of medicinal plant, Stevia rebaudiana (Bertoni) Bertoni. The separation was achieved using the solvents ethyl acetate-benzene (1:1, v/v) as the mobile phase, followed by scanning and quantification at 295 nm. Densitometric analysis of leaf extract resulted in compact spots for JA at Rf = 0...
February 13, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28254632/metabolic-and-inflammatory-responses-to-the-common-sweetener-stevioside-and-a-glycemic-challenge-in-horses-with-equine-metabolic-syndrome
#14
S E Elzinga, B Rohleder, B Schanbacher, K McQuerry, V D Barker, A A Adams
Extracts derived from the leaves of the stevia plant (stevioside) are commonly used as sweeteners for humans and horses. Stevioside appears to be safe for human consumption, including for individuals with insulin dysregulation. In the horse, the safety or metabolic effects of stevioside on normal animals or on those with metabolic dysfunction are unknown. Furthermore, the inflammatory response to a glycemic challenge or to stevioside in horses is not well defined. Therefore, the objective of this study was to measure the effects of stevioside and a glycemic challenge on insulin, glucose, and inflammatory responses in horses with a common metabolic dysfunction (equine metabolic syndrome or EMS) compared with non-EMS controls...
February 4, 2017: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/28251728/tandem-mass-spectrometry-a-convenient-approach-in-the-dosage-of-steviol-glycosides-in-stevia-sweetened-commercial-food-beverages
#15
Leonardo Di Donna, Fabio Mazzotti, Ilaria Santoro, Giovanni Sindona
The use of sweeteners extracted from leaves of the plant species Stevia Rebaudiana is worldwide increasing. They are recognized as GRAS (Generally Recognized as Safe) by US-FDA and approved by EU-EFSA, with some recommendation on the daily dosage that should not interfere with glucose metabolism. The results here presented introduce an easy analytical approach for the identification and assay of Stevia sweeteners in commercially available soft drink, based on Liquid Chromatography (LC) coupled to Tandem Mass Spectrometry (MS/MS), using a natural statin like molecule, Brutieridin, as internal standard...
March 1, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28218969/stability-of-the-stevia-derived-sweetener-rebaudioside-a-in-solution-as-affected-by-ultraviolet-light-exposure
#16
Jiewen Zhang, Leonard N Bell
Rebaudioside A is a natural noncaloric high-potency sweetener extracted from the leaves of Stevia rebaudiana. With rebaudioside A use increasing in foods, understanding the factors affecting its stability is necessary. This project evaluated the degradation rate constants of rebaudioside A in water, 0.1 M phosphate buffer, and 0.1 M citrate buffer at pH 3 and 7 as a function of ultraviolet (UV) light intensity (365 nm, 0 μW/cm(2) for dark conditions, 27 μW/cm(2) for low intensity, and 190 μW/cm(2) for high intensity) at 32...
April 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28215607/impact-of-blue-red-and-far-red-light-treatments-on-gene-expression-and-steviol-glycoside-accumulation-in-stevia-rebaudiana
#17
Yuki Yoneda, Hiroshi Nakashima, Juro Miyasaka, Katsuaki Ohdoi, Hiroshi Shimizu
Stevia rebaudiana (Bertoni) Bertoni is a plant that biosynthesizes a group of natural sweeteners that are up to approximately 400 times sweeter than sucrose. The sweetening components of S. rebaudiana are steviol glycosides (SGs) that partially share their biosynthesis pathway with gibberellins (GAs). However, the molecular mechanisms through which SGs levels can be improved have not been studied. Therefore, transcription levels of several SG biosynthesis-related genes were analyzed under several light treatments involved in GA biosynthesis...
May 2017: Phytochemistry
https://www.readbyqxmd.com/read/28193409/a-new-natural-source-for-obtainment-of-inulin-and-fructo-oligosaccharides-from-industrial-waste-of-stevia-rebaudiana-bertoni
#18
Sheila Mara Sanches Lopes, Gabriela Krausová, José Walter Pedroza Carneiro, José Eduardo Gonçalves, Regina Aparecida Correia Gonçalves, Arildo José Braz de Oliveira
Fructan-type inulin and fructo-oligosaccharides (FOS) are reserve polysaccharides that offer an interesting combination of nutritional and technological properties for food industry. Stevia rebaudiana is used commercially in the sweetener industry due to the high content of steviol glycosides in its leaves. With the proposal of using industrial waste, the objective of the present study was to isolate, characterize and evaluate the prebiotic activity of inulin and FOS from S. rebaudiana stems. The chemical characterization of the samples by GC-MS, NMR and off-line ESI-MS showed that it was possible to obtain inulin molecules from the S...
June 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28146121/a-novel-diterpene-glycoside-with-nine-glucose-units-from-stevia-rebaudiana-bertoni
#19
Indra Prakash, Gil Ma, Cynthia Bunders, Romila D Charan, Catherine Ramirez, Krishna P Devkota, Tara M Snyder
Following our interest in new diterpene glycosides with better taste profiles than that of Rebaudioside M, we have recently isolated and characterized Rebaudioside IX-a novel steviol glycoside-from a commercially-supplied extract of Stevia rebaudiana Bertoni. This molecule contains a hexasaccharide group attached at C-13 of the central diterpene core, and contains three additional glucose units when compared with Rebaudioside M. Here we report the complete structure elucidation-based on extensive Nuclear Magnetic Resonance (NMR) analysis (1H, 13C, Correlation Spectroscopy (COSY), Heteronuclear Single Quantum Coherence-Distortionless Enhancement Polarization Transfer (HSQC-DEPT), Heteronuclear Multiple Bond Correlation (HMBC), 1D Total Correlation Spectroscopy (TOCSY), Nuclear Overhauser Effect Spectroscopy (NOESY)) and mass spectral data-of this novel diterpene glycoside with nine sugar moieties and containing a relatively rare 16 α-linked glycoside...
January 31, 2017: Biomolecules
https://www.readbyqxmd.com/read/28126702/stevia-based-sweeteners-as-a-promising-alternative-to-table-sugar-the-effect-on-listeria-monocytogenes-and-salmonella-typhimurium-growth-dynamics
#20
María M Lobete, Maria Baka, Estefanía Noriega, Etienne Jooken, Annick Monballiu, Sam de Beurme, Boudewijn Meesschaert, Jan F Van Impe
Sugar is commonly substituted with stevia-based products in food industry and in our daily-life. This substitution results in a change in food product characteristic formula and properties that may affect the growth dynamics of food pathogenic and spoilage bacteria. This work studies the effect of table sugar (TS), laboratory sucrose (LS), commercial stevia (St) and steviol glycosides (SG) on the growth dynamics of Salmonella Typhimurium and Listeria monocytogenes. Experiments were carried out in general and minimal culture media at 3 equivalent concentration levels in terms of sweetness intensity (TS and LS at 3, 9 and 15% (w/v); St at 0...
March 20, 2017: International Journal of Food Microbiology
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