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Artemisia

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https://www.readbyqxmd.com/read/28543086/allergen-immunotherapy-for-allergic-asthma-a-systematic-review-and-meta-analysis
#1
REVIEW
Sangeeta Dhami, Artemisia Kakourou, Felix Asamoah, Ioana Agache, Susanne Lau, Jutel Marek, Antonella Muraro, Graham Roberts, Cezmi A Akdis, Matteo Bonini, Ozlem Cavkaytar, Breda Flood, Pawel Gajdanowicz, Kenji Izuhara, Ömer Kalayci, Ralph Mosges, Oscar Palomares, Oliver Pfaar, Sylwia Smolinska, Milena Sokolowska, Miqdad Asaria, Gopal Netuveli, Hader Zaman, Ather Akhlaq, Aziz Sheikh
BACKGROUND: To inform the development of the European Academy of Allergy and Clinical Immunonology's (EAACI) Guidelines on Allergen Immunotherapy (AIT) for allergic asthma, we assessed the evidence on the effectiveness, cost-effectiveness and safety of AIT. METHODS: We performed a systematic review, which involved searching nine databases. Studies were screened against pre-defined eligibility criteria and critically appraised using established instruments. Data were synthesized using random-effects meta-analyses...
May 19, 2017: Allergy
https://www.readbyqxmd.com/read/28539062/two-new-flavonoids-from-artemisia-argyi-with-their-anticoagulation-activities
#2
Jie-Li Lv, Zhen-Zhen Li, Lai-Bin Zhang
A new flavone glycoside, eupatilin 7-O-β-d-glucopyranoside (1) and a new flavone, 5,6,2',4'-tetrahydroxy-7,5'-dimethoxyflavone (2), were isolated from Artemisia argyi. Their structures were unambiguously elucidated by extensive spectroscopic analysis. Both flavonoids were evaluated for in vitro anticoagulation activities. Compound 1 significantly extended thrombin time. Compound 2 had obvious effect in increasing prothrombin time.
May 25, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28534178/effects-of-foliage-litter-of-a-pioneer-shrub-artemisia-halodendron-on-germination-from-the-soil-seedbank-in-a-semi-arid-sandy-grassland-in-china
#3
Yongqing Luo, Xueyong Zhao, Yuqiang Li, Tao Wang
Vegetation recovery during succession is an important process for ecological restoration of the soil, especially in degraded sandy land. However, the driving mechanisms, such as how a pioneer species competes with other species, is uncertain. In China's Horqin Sandy Land, Artemisia halodendron is an important shrub that is common on semi-fixed dunes, where it replaces Agriophyllum squarrosum during succession, and is an important indicator species of the second stage of dune stabilization. However, how it outcompetes other species is still unclear...
May 22, 2017: Journal of Plant Research
https://www.readbyqxmd.com/read/28533790/aapdr3-a-pdr-transporter-3-is-involved-in-sesquiterpene-%C3%AE-caryophyllene-transport-in-artemisia-annua
#4
Xueqing Fu, Pu Shi, Qian He, Qian Shen, Yueli Tang, Qifang Pan, Yanan Ma, Tingxiang Yan, Minghui Chen, Xiaolong Hao, Pin Liu, Ling Li, Yuliang Wang, Xiaofen Sun, Kexuan Tang
Artemisinin, a sesquiterpenoid endoperoxide, isolated from the plant Artemisia annua L., is widely used in the treatment of malaria. Another sesquiterpenoid, β-caryophyllene having antibiotic, antioxidant, anticarcinogenic and local anesthetic activities, is also presented in A. annua. The role played by sesquiterpene transporters in trichomes and accumulation of these metabolites is poorly understood in A. annua and in trichomes of other plant species. We identified AaPDR3, encoding a pleiotropic drug resistance (PDR) transporter located to the plasma membrane from A...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28532258/fumigant-and-repellent-activities-of-essential-oil-extracted-from-artemisia-dubia-and-its-main-compounds-against-two-stored-product-pests
#5
Jun-Yu Liang, Shan-Shan Guo, Wen-Juan Zhang, Zhu-Feng Geng, Zhi-Wei Deng, Shu-Shan Du, Ji Zhang
The major chemical constituents of the essential oil extracted from Artemisia dubia wall. ex Bess. (Family: Asteraceae) were found as terpinolene (19.02%), limonene (17.40%), 2,5-etheno[4.2.2]propella-3,7,9-triene (11.29%), isoelemicin (11.05%) and p-cymene-8-ol (5.93%). Terpinolene and limonene were separated as main components from the essential oil. The essential oil showed fumigant toxicity against Tribolium castaneum and Liposcelis bostrychophila with LC50 values of 49.54 and 0.74 mg/L, respectively. The essential oil and isolated compounds of A...
May 22, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28530200/antioxidant-antibacterial-and-anticancer-properties-of-phyto-synthesised-artemisia-quttensis-podlech-extract-mediated-agnps
#6
Farinaz Ghanbar, Amir Mirzaie, Fatemeh Ashrafi, Hassan Noorbazargan, Mojgan Dalirsaber Jalali, Soheil Salehi, Seyed Ataollah Sadat Shandiz
The focus of this study is on a rapid and cost-effective approach for the synthesis of silver nanoparticles (AgNPs) using Artemisia quttensis Podlech aerial parts extract and assessment of their antioxidant, antibacterial and anticancer activities. The prepared AgNPs were determined by ultraviolet-visible spectroscopy, X-ray diffraction, Fourier transform infra-red spectroscopy, transmission electron microscopy, scanning electron microscopy, energy-dispersive spectroscopy, and dynamic light scattering and zeta-potential analysis...
June 2017: IET Nanobiotechnology
https://www.readbyqxmd.com/read/28526743/systematic-identification-of-functional-residues-of-artemisia-annua-amorpha-4-11-diene-synthase
#7
Xin Fang, Jian-Xu Li, Jin-Quan Huang, You-Li Xiao, Peng Zhang, Xiao-Ya Chen
Terpene synthases (TPSs) are responsible for the extremely diversified and complex structure of terpenoids. Amorpha-4,11-diene synthase (ADS) has a high (90%) fidelity in generating the sesquiterpene precursor for biosynthesis of artemisinin, an antimalarial drug, however, little is known about how active site residues of ADS involved in the carbocation rearrangement and cyclization reactions. Here, we identify seven residues that are key to most of the catalytic steps in ADS. By structural modeling and amino acid sequence alignments of ADS with two functionally relevant sesquiterpene synthases from Artemisia annua, we performed site-directed mutagenesis and found that a single substitution, T296V, impaired the ring closure activity almost completely, and tetra-substitutions (L374Y/L404V/L405I/G439S) led to an enzyme generating 80% monocyclic bisabolyl-type sesquiterpenes, whereas a double mutant (T399L/T447G) showed compromised activity in regioselective deprotonation to yield 34...
May 19, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28525595/gut-transcriptome-analysis-shows-different-food-utilization-efficiency-by-the-grasshopper-oedaleous-asiaticus-orthoptera-acrididae
#8
Xunbing Huang, Mark Richard McNeill, Jingchuan Ma, Xinghu Qin, Xiongbing Tu, Guangchun Cao, Guangjun Wang, Xiangqun Nong, Zehua Zhang
Oedaleus asiaticus B. Bienko is a persistent pest occurring in north Asian grasslands. We found that O. asiaticus feeding on Stipa krylovii Roshev. had higher approximate digestibility (AD), efficiency of conversion of ingested food (ECI), and efficiency of conversion of digested food (ECD), compared with cohorts feeding on Leymus chinensis (Trin.) Tzvel, Artemisia frigida Willd., or Cleistogenes squarrosa (Trin.) Keng. Although this indicated high food utilization efficiency for S. krylovii, the physiological processes and molecular mechanisms underlying these biological observations are not well understood...
May 19, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/28512639/inhibitory-effect-of-chemical-constituents-isolated-from-artemisia-iwayomogi-on-polyol-pathway-and-simultaneous-quantification-of-major-bioactive-compounds
#9
Yoon Kyoung Lee, Eun Young Hong, Wan Kyunn Whang
Blocking the polyol pathway plays an important role preventing diabetic complications. Therefore, aldose reductase (AR) and advanced glycation endproducts (AGEs) formation has significant effect on diabetic complications. Artemisia iwayomogi has long been used as treatment of various diseases in Korea. However, no literatures have reported on AR and AGEs formation inhibitory activities of A. iwayomogi. For these reasons, we aimed to assess that A. iwayomogi had potential as anti-diabetic complications agents...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28496477/cytotoxic-properties-of-three-isolated-coumarin-hemiterpene-ether-derivatives-from-artemisia-armeniaca-lam
#10
Mahdi Mojarrab, Seyed Ahmad Emami, Abbas Delazar, Zahra Tayarani-Najaran
Considering multiple reports on cytotoxic activity of the Artemisia genus and its phytochemicals, in the current study A. armeniaca Lam. and the three components isolated from the plant were subjected to cytotoxic studies. Analytical fractionation of A. armeniaca aerial parts for the first time was directed to the isolation of 7-hydroxy-8-(4-hydroxy-3-methylbutoxy) comarin (armenin), 8-hydroxy-7-(4-hydroxy-3-methylbutoxy) comarin (isoarmenin) and deoxylacarol. Cytotoxicity assessed with alamalBlue® assay and apoptosis was detected by PI staining and western blot analysis of Bax and PARP proteins...
2017: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/28488391/essential-oil-variability-in-natural-populations-of-artemisia-campestris-l-and-artemisia-herba-alba-asso-and-incidence-on-antiacetylcholinesterase-and-antioxidant-activities
#11
Faten Younsi, Sameh Mehdi, Oumayma Aissi, Najoua Rahali, Rym Jaouadi, Mohamed Boussaid, Chokri Messaoud
The intraspecific variability of A. herba-alba and A. campestris essential oils and the evaluation of their antioxidant and antiacetylcholinesterase activities were determined. A. herba-alba essential oil was found rich in camphor (19.61%), α-thujone (19.40%), β-thujone (9.44%), chrysanthenone (9.26%) and trans-sabinyl acetate (8.43%). The major compounds of A. campestris essential oil were germacrene D (16.38%), β-pinene (16.33%) and limonene (9.17%). Significant variation in the essential oil composition was observed among populations of each species...
May 10, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28487065/a-comprehensive-study-on-in-vitro-and-in-vivo-toxicological-evaluation-of-artemisia-capillaris
#12
Jun-Won Yun, Seung-Hyun Kim, Yun-Soon Kim, Ji-Ran You, Eun-Young Cho, Jung-Hee Yoon, Euna Kwon, Jae Hun Ahn, Ja-June Jang, Jeong-Hwan Che, Byeong-Cheol Kang
Artemisia capillaris (AC) has been used as an alternative therapy in obesity, atopic dermatitis, and liver diseases through several biological activity including anti-steatotic, antioxidant, and anti-inflammatory activities. Despite its ethnomedicinal benefits, no sufficient background information is available about the long-term safety and genotoxicity of the AC extract. Therefore, the present study was carried out to investigate the 13-week subchronic toxicity and genotoxicity of the AC extract according to the test guidelines published by the Organization for Economic Cooperation and Development...
May 6, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28486507/water-soluble-carbohydrates-of-root-components-and-activity-rhythms-at-vegetative-growth-stage-of-artemisia-scoparia-in-northeastern-grassland-of-china
#13
Shiyu Wang, Yunfei Yang, Heng Zhi
The root system of perennials is composed of the roots of different growth years. The nutrient storage capacities and activities of roots are an important basis for judging root components and plant senescence. In this research, changes in the contents of water-soluble carbohydrate (WSC) were used as indicators of the nutrient storage and activity of roots of different life years. From the early resprouting stage to the rapid growth stage, Artemisia scoparia L. plants of 1-3 age classes were sampled and measured once every 18 days...
2017: PloS One
https://www.readbyqxmd.com/read/28482306/mapping-allergenic-pollen-vegetation-in-uk-to-study-environmental-exposure-and-human-health
#14
Rachel N McInnes, Deborah Hemming, Peter Burgess, Donna Lyndsay, Nicholas J Osborne, Carsten Ambelas Skjøth, Sam Thomas, Sotiris Vardoulakis
Allergenic pollen is produced by the flowers of a number of trees, grasses and weeds found throughout the UK. Exposure to such pollen grains can exacerbate pollen-related asthma and allergenic conditions such as allergic rhinitis (hay fever). Maps showing the location of these allergenic taxa have many applications: they can be used to provide advice on risk assessments; combined with health data to inform research on health impacts such as respiratory hospital admissions; combined with weather data to improve pollen forecasting systems; or as inputs to pollen emission models...
May 5, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28477002/biosynthesis-of-silver-nanoparticles-using-artemisia-annua-callus-for-inhibiting-stem-end-bacteria-in-cut-carnation-flowers
#15
Qian Hua Xia, Li Ping Zheng, Pei Fei Zhao, Jian Wen Wang
A biological method for synthesising silver nanoparticles (AgNPs) was developed using the callus extracts from Artemisia annua L. under sunlight at 25,000 lx. The AgNPs were characterised using transmission electron microscopy, atomic force microscope, X-ray diffraction and Fourier transform infrared spectroscopy. The AgNPs were mostly spherical with the size of 2.1 to 45.2 nm (average 10.9 nm). Pulse treatments of AgNPs at 125, 250 and 500 mg/l for 1 h extended vase life of cut carnation (Dianthus caryophyllus cv...
March 2017: IET Nanobiotechnology
https://www.readbyqxmd.com/read/28472675/toxic-essential-oils-part-v-behaviour-modulating-and-toxic-properties-of-thujones-and-thujone-containing-essential-oils-of-salvia-officinalis-l-artemisia-absinthium-l-thuja-occidentalis-l-and-tanacetum-vulgare-l
#16
Niko S Radulović, Marija S Genčić, Nikola M Stojanović, Pavle J Randjelović, Zorica Z Stojanović-Radić, Nenad I Stojiljković
Neurotoxic thujones (α- and β-diastereoisomers) are common constituents of plant essential oils. In this study, we employed a statistical approach to determine the contribution of thujones to the overall observed behaviour-modulating and toxic effects of essential oils (Salvia officinalis L., Artemisia absinthium L., Thuja occidentalis L. and Tanacetum vulgare L.) containing these monoterpene ketones. The data from three in vivo neuropharmacological tests on rats (open field, light-dark, and diazepam-induced sleep), and toxicity assays (brine shrimp, and antimicrobial activity against a panel of microorganisms), together with the data from detailed chemical analyses, were subjected to a multivariate statistical treatment to reveal the possible correlation(s) between the content of essential-oil constituents and the observed effects...
May 1, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28454566/apoptosis-induced-effects-of-extract-from-artemisia-annua-linn%C3%A3-by-modulating-pten-p53-pdk1-akt-signal-pathways-through-pten-p53-independent-manner-in-hct116-colon-cancer-cells
#17
Eun Ji Kim, Guen Tae Kim, Bo Min Kim, Eun Gyeong Lim, Sang-Yong Kim, Young Min Kim
BACKGROUND: The extracts from Artemisia annua Linné (AAE) has been known to possess various functions including anti-bacterial, anti-virus and anti-oxidant effects. However, the mechanism of those effects of AAE is not well known. Pursuantly, we determined the apoptotic effects of extract of AAE in HCT116 cell. In this study, we suggested that AAE may exert cancer cell apoptosis through PTEN/PDK1/Akt/p53signal pathway and mitochondria-mediated apoptotic proteins. METHODS: We measured 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, lactate dehydrogenase (LDH) assay, Hoechst 33342 staining, Annexin V-PI staining, Mitopotential assay, immunofluorescence (IF) and Western blotting...
April 28, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28447741/effect-of-isosecotanapartholide-isolated-from-artemisia%C3%A2-princeps-pampanini-on-il%C3%A2-33-production-and-stat%C3%A2-1-activation-in-hacat-keratinocytes
#18
Chang Taek Oh, Yu-Jin Jang, Tae-Rin Kwon, Songi Im, Soon Re Kim, Joon Seok, Gun-Yong Kim, Young-Heui Kim, Seog Kyun Mun, Beom Joon Kim
The present study aimed to investigate the anti‑inflammatory effect and mechanism of action of isosecotanapartholide (ISTP), isolated from Artemisia princeps Pampanini extract (APE). The effects of ISTP and APE on the proliferation of human keratinocytes following stimulation by tumor necrosis factor‑α/interferon‑γ were assessed. ISTP and APE downregulated the expression levels of signal transducer and activator of transcription‑1 (STAT‑1), and reduced interleukin‑33 (IL‑33) production. ISTP and APE inhibited the mRNA expression levels of thymus and activation‑regulated chemokine (TARC/CCL17) in a dose‑dependent manner...
May 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28440881/overexpression-of-a-type-i-isopentenyl-pyrophosphate-isomerase-of-artemisia-annua-in-the-cytosol-leads-to-high-arteannuin-b-production-and-artemisinin-increase
#19
Dongming Ma, Gui Li, Fatima Alejos-Gonzalez, Yue Zhu, Zhen Xue, Aimin Wang, Hui Zhang, Xing Li, Hechun Ye, Hong Wang, Benye Liu, De-Yu Xie
We recently characterized a gene-terpene network that is associated with artemisinin biosynthesis in self-pollinated (SP) Artemisia annua, an effective antimalarial plant. We hypothesize that an alteration of gene expression in the network may improve the production of artemisinin and its precursors. In this study, we cloned an isopentenyl pyrophosphate isomerase (IPPI) cDNA, AaIPPI1, from Artemisia annua (Aa). The full-length cDNA encodes a type I IPPI containing a plastid transit peptide (PTP) at its amino terminus...
April 25, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28438564/essential-oil-of-artemisia-argyi-suppresses-inflammatory-responses-by-inhibiting-jak-stats-activation
#20
Lin-Lin Chen, Hao-Jun Zhang, Jung Chao, Jun-Feng Liu
ETHNOPHARMACOLOGICAL RELEVANCE: Artemisia argyi is a herbal medicine traditionally used in Asia for the treatment of bronchitis, dermatitis and arthritis. Recent studies revealed the anti-inflammatory effect of essential oil in this plant. However, the mechanisms underlying the therapeutic potential have not been well elucidated. The present study is aimed to verify anti-inflammatory effect and investigate the probable mechanisms. MATERIALS AND METHODS: The essential oil from Artemisia argyi (AAEO) was initially tested against LPS-induced production of inflammatory mediators and cytokines in RAW264...
April 21, 2017: Journal of Ethnopharmacology
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