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https://www.readbyqxmd.com/read/29909120/integrated-in-silico-in-vitro-strategy-for-screening-of-some-traditional-egyptian-plants-for-human-aromatase-inhibitors
#1
Hend M Dawood, Reham S Ibrahim, Eman Shawky, Hala M A Hammoda, Aly M Metwally
ETHNOPHARMACOLOGICAL RELEVANCE: Aromatase enzyme (CYP19) is widely known as a critical target protein for treating hormone-dependent breast cancer. Natural products from traditional medicinal plants continue to be an active source of aromatase inhibitors. Meanwhile, high cost of experimental work and low hit rate associated with HTS have stimulated the implementation of in-silico virtual screening to resolve these pitfalls, where coupling of both classical wet lab procedure and VS may offer a more deepened access to bioactive compounds with less work and time waste...
June 14, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29900359/data-on-seed-germination-using-led-versus-fluorescent-light-under-growth-chamber-conditions
#2
Rabab Sanoubar, Roberta Calone, Enrico Noli, Lorenzo Barbanti
The present investigation attempted to assess the influence of two light sources, LED versus fluorescent light, on seed germination of nine aromatic species belonging to the genus Artemisia , Atriplex , Chenopodium , Salicornia , Sanguisorba , Portulaca and Rosmarinus . Pre-germination test was carried out in petri dishes, evidencing the need to overcome seed dormancy through cold stratification in Salicornia europaea . Thereafter, seeds were germinated in small trays with peat moss substrate in two growth chambers illuminated with either LED or fluorescent light featuring similar photosynthetic photon flux density...
August 2018: Data in Brief
https://www.readbyqxmd.com/read/29896204/silencing-amorpha-4-11-diene-synthase-genes-in-artemisia-annua-leads-to-fpp-accumulation
#3
Theresa M Catania, Caroline A Branigan, Natalia Stawniak, Jennifer Hodson, David Harvey, Tony R Larson, Tomasz Czechowski, Ian A Graham
Artemisia annua is established as an efficient crop for the production of the anti-malarial compound artemisinin, a sesquiterpene lactone synthesized and stored in Glandular Secretory Trichomes (GSTs) located on the leaves and inflorescences. Amorpha-4,11-diene synthase (AMS) catalyzes the conversion of farnesyl pyrophosphate (FPP) to amorpha-4,11-diene and diphosphate, which is the first committed step in the synthesis of artemisinin. FPP is the precursor for sesquiterpene and sterol biosynthesis in the plant...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29894861/structural-and-molecular-strategy-of-photosynthetic-apparatus-organisation-of-wild-flora-halophytes
#4
Olga Rozentsvet, Viktor Nesterov, Elena Bogdanova, Аnatoly Kosobryukhov, Svetlana Subova, Galina Semenova
Structural and molecular parameters of photosynthetic apparatus in plants with different strategies for the accumulation of salts were investigated. CO2 gas exchange rate, content of pigments, mesostructure, chloroplast ultrastructure and the biochemical composition of the membrane structural components in leaves were measured. The objects of the study were euhalophytes (Salicornia perennans, Suaeda salsa, Halocnemum strobilaceum), crynohalophyte (Limonium gmelinii), glycohalophyte (Artemisia santonica). Euhalophytes S...
June 7, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29890315/anti-hepatitis-b-virus-effects-of-the-traditional-chinese-herb-artemisia-capillaris-and-its-active-enynes
#5
Chang-An Geng, Tong-Hua Yang, Xiao-Yan Huang, Jing Yang, Yun-Bao Ma, Tian-Ze Li, Xue-Mei Zhang, Ji-Jun Chen
ETHNOPHARMACOLOGICAL RELEVANCE: Artemisia capillaris (Yin-Chen) is a famous traditional Chinese medicine (TCM) for treating acute and chronic hepatitis in China. Enynes are one type of characteristic constituents in this herb, while their anti-hepatitis B virus (anti-HBV) properties have not been systemically investigated. AIM OF THE STUDY: This study is to reveal the active part of A. capillaris, and systemically investigate the enynes and their anti-HBV activity...
June 8, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29872986/relationship-between-concentration-of-rare-earth-elements-in-soil-and-their-distribution-in-plants-growing-near-a-frequented-road
#6
Patrycja Mleczek, Klaudia Borowiak, Anna Budka, Przemysław Niedzielski
Rare earth elements (REEs) are a group of elements whose concentration in numerous environmental matrices continues to increase; therefore, the use of biological methods for their removal from soil would seem to be a safe and reasonable approach. The aim of this study was to estimate the phytoextraction efficiency and distribution of light and heavy (LREEs and HREEs) rare earth elements by three herbaceous plant species: Artemisia vulgaris L., Taraxacum officinale F.H. Wigg. and Trifolium repens L., growing at a distance of 1, 10, and 25 m from the edge of a frequented road in Poland...
June 5, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29869797/ribavirin-for-treating-crimean-congo-haemorrhagic-fever
#7
REVIEW
Samuel Johnson, Nicholas Henschke, Nicola Maayan, Inga Mills, Brian S Buckley, Artemisia Kakourou, Rachel Marshall
BACKGROUND: Crimean Congo haemorrhagic fever (CCHF) is a tick-borne disease that occurs in parts of Asia, Europe and Africa. Since 2000 the infection has caused epidemics in Turkey, Iran, Russia, Uganda and Pakistan. Good-quality general supportive medical care helps reduce mortality. There is uncertainty and controversy about treating CCHF with the antiviral drug ribavirin. OBJECTIVES: To assess the effects of ribavirin for treating people with Crimean Congo haemorrhagic fever...
June 5, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29868094/detailed-phytochemical-analysis-of-high-and-low-artemisinin-producing-chemotypes-of-artemisia-annua
#8
Tomasz Czechowski, Tony R Larson, Theresa M Catania, David Harvey, Cenxi Wei, Michel Essome, Geoffrey D Brown, Ian A Graham
Chemical derivatives of artemisinin, a sesquiterpene lactone produced by Artemisia annua , are the active ingredient in the most effective treatment for malaria. Comprehensive phytochemical analysis of two contrasting chemotypes of A. annua resulted in the characterization of over 80 natural products by NMR, more than 20 of which are novel and described here for the first time. Analysis of high- and low-artemisinin producing (HAP and LAP) chemotypes of A. annua confirmed the latter to have a low level of DBR2 (artemisinic aldehyde Δ11(13) reductase) gene expression...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29861834/an-extract-of-artemisia-dracunculus-l-promotes-psychological-resilience-in-a-mouse-model-of-depression
#9
Jun Wang, Adelaida Esteban Fernández, Simoni Tiano, Jing Huang, Elizabeth Floyd, Alexander Poulev, David Ribnicky, Giulio M Pasinetti
Stress-induced peripheral inflammation contributes to depression-like behaviors in both human and experimental models. PMI 5011, a botanical extract of Artemisia dracunculus L., was previously shown to have multiple bioactivities, including anti-inflammatory activity. In this work, using a repeated social defeat stress (RSDS) model of depression, we demonstrate that oral administration of the botanical extract PMI 5011 promotes resilience to RSDS-mediated depression-like phenotypes. We also show that the behavioral improvements are associated with attenuation of stress-mediated induction of inflammatory cytokines in the periphery and alteration of synaptic plasticity in the nucleus accumbens (NAc)...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29861773/the-flavonoid-jaceosidin-from-artemisia-princeps-induces-apoptotic-cell-death-and-inhibits-the-akt-pathway-in-oral-cancer-cells
#10
Hye-Yeon Han, Hyung Joon Kim, Seung-Hwa Jeong, Jiyeon Kim, Sung-Hee Jeong, Gyoo Cheon Kim, Dae-Seok Hwang, Uk-Kyu Kim, Mi Heon Ryu
Jaceosidin is a single compound from the Japanese mugwort Artemisia princeps , which is used as a food and a traditional medicinal herb. A. princeps extracts and flavonoid components have been shown to have antihyperglycaemic, antioxidant, and anti-inflammatory properties. Although the anticancer properties of these extracts were recently demonstrated, the related mechanisms have not been characterised. In this study, we investigated the effects of jaceosidin in oral squamous cell carcinoma (OSCC) cells and initially showed selective suppression of proliferation (IC50 = 82...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29857558/red-and-blue-light-promote-the-accumulation-of-artemisinin-in-artemisia-annua-l
#11
Dong Zhang, Wei Sun, Yuhua Shi, Lan Wu, Tianyuan Zhang, Li Xiang
Artemisinin, which has been isolated from Artemisia annua L., is the most effective antimalarial drug and has saved millions of lives. In addition, artemisinin and its derivatives have anti-tumor, anti-parasitic, anti-fibrosis, and anti-arrhythmic properties, which enhances the demand for these compounds. Improving the content of artemisinin in A. annua is therefore becoming an increasing research interest, as the chemical synthesis of this metabolite is not viable. Ultraviolet B and C irradiation have been reported to improve the artemisinin content in A...
May 31, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29845596/defoliation-and-arbuscular-mycorrhizal-fungi-shape-plant-communities-in-overgrazed-semi-arid-grasslands
#12
Xin Yang, Yue Shen, Nan Liu, Gail W T Wilson, Adam B Cobb, Yingjun Zhang
Overgrazing substantially contributes to global grassland degradation by decreasing plant community productivity and diversity through trampling, defoliation, and removal of nutrients. Arbuscular mycorrhizal (AM) fungi also play a critical role in plant community diversity, composition, and primary productivity, maintaining ecosystem functions. However, interactions between grazing disturbances, such as trampling and defoliation, and AM fungi in grassland communities are not well known. We examined influences of trampling, defoliation, and AM fungi on semi-arid grassland plant community composition for three years, by comparing all combinations of these factors...
May 30, 2018: Ecology
https://www.readbyqxmd.com/read/29803465/towards-a-better-understanding-of-artemisia-vulgaris-botany-phytochemistry-pharmacological-and-biotechnological-potential
#13
REVIEW
Rambod Abiri, Abraão Lincoln Macedo Silva, Ludmilla Santos Silva de Mesquita, José Wilson Carvalho de Mesquita, Narges Atabaki, Eduardo Bezerra de Almeida, Noor Azmi Shaharuddin, Sonia Malik
Artemisia vulgaris is one of the important medicinal plant species of the genus Artemisia, which is usually known for its volatile oils. The genus Artemisia has become the subject of great interest due to its chemical and biological diversity as well as the discovery and isolation of promising anti-malarial drug artemisinin. A. vulgaris has a long history in treatment of human ailments by medicinal plants in various parts of the world. This medicinal plant possesses a broad spectrum of therapeutic properties including: anti-malarial, anti-inflammatory, anti-hypertensive, anti-oxidant, anti-tumoral, immunomodulatory, hepatoprotective, anti-spasmodic and anti-septic...
July 2018: Food Research International
https://www.readbyqxmd.com/read/29796216/medicinal-herbs-in-the-treatment-of-neuropathic-pain-a-review
#14
REVIEW
Fatemeh Forouzanfar, Hossein Hosseinzadeh
Chronic neuropathic pain is a common significant and debilitating problem that presents a major challenge to health-care. Despite the large number of available drugs, there are no curative conventional treatments for neuropathic pain. Nowadays, more attention has been focused on the herbal formulation in the field of drug discovery. Therefore, we performed an extensive review about herbal drugs and plants that exhibited protective effects on neuropathic pain. In this review, the beneficial effects of each plant in different neuropathic pain model, either in animals or in patients are reported...
April 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29793324/evaluation-of-the-antithrombotic-activity-of-zhi-xiong-capsules-a-traditional-chinese-medicinal-formula-via-the-pathway-of-anti-coagulation-anti-platelet-activation-and-anti-fibrinolysis
#15
Jingjing Zhou, Zehai Song, Mingshu Han, Baoxing Yu, Guanghui Lv, Na Han, Zhihui Liu, Jun Yin
Zhi-Xiong Capsules (ZXC) involving Hirudo, Ligusticum chuanxiong, Salvia miltiorrhiza, Leonurus artemisia, and Pueraria lobata, is an empirical prescription used in Chinese clinics applied for treating cerebral arteriosclerosis and blood-stasis in clinic. However, the mechanism of its antithrombotic activity has not been investigated until now. The present study was designed to investigate its antithrombotic effects, the mechanism of ZXC on anti-thrombus action and to identify the main chemical composition of ZXC using HPLC-DAD-ESI-IT-TOF-MS...
January 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29787986/anti-inflammatory-effects-and-mechanism-of-the-total-flavonoids-from-artemisia-scoparia-waldst-et-kit-in-vitro-and-in-vivo
#16
Xue Wang, Hua Huang, Xueping Ma, Linlin Wang, Chong Liu, Biyu Hou, Shengqian Yang, Li Zhang, Guanhua Du
Artemisia scoparia Waldst. et Kit. is traditionally used for the treatment of jaundice urinary retention, itching wet sores, infectious icteric hepatitis and influenza in Uighur medicine. This study aimed to further illuminate the anti-inflammatory effects and mechanism of the total flavonoids (ASTF) from Artemisia scoparia Waldst. et Kit. In vitro, RAW 264.7 cells were pretreated with ASTF 1 h before stimulation with LPS (1 μg/mL) for 24 h. Then, the concentrations of NO, PGE2 , TNF-α, IL-6 and MCP-1 in the medium were determined...
May 19, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29783993/cirsimaritin-inhibits-influenza-a-virus-replication-by-downregulating-the-nf-%C3%AE%C2%BAb-signal-transduction-pathway
#17
Haiyan Yan, Huiqiang Wang, Linlin Ma, Xueping Ma, Jinqiu Yin, Shuo Wu, Hua Huang, Yuhuan Li
BACKGROUND: Artemisia scoparia Waldst and Kit is a famous traditional Chinese medicine widely distributed in Xinjiang, China. Flavonoids extracted from it exhibits inhibitory activities against several influenza virus strains. Despite this fact, the antiviral properties of CST, one of such flavonoids, against the influenza virus has not been reported. Thus, the aim of this study is to investigate the anti-influenza virus efficacy and antiviral mechanism of CST. METHODS: The inhibitory activity of CST against influenza viruses was assessed by using viral titers and performing Western blot, qRT-PCR, and immunofluorescence assays in Madin-Darby canine kidney (MDCK) cells and a human monocytic cell line (THP-1)...
May 21, 2018: Virology Journal
https://www.readbyqxmd.com/read/29783231/allergenic-weed-pollen-forecast-under-the-mathematical-modeling-method-implementation-in-ukraine
#18
Irina I Motruk, Michael Yu Antomonov, Victoria V Rodinkova, Olena E Aleksandrova, Oleh V Yermishev
OBJECTIVE: Introduction: Allergies are the most common reason of the chronic diseases in developed countries and represent an important medical, social and economic issue, the relevance of which is growing both in these countries and in Ukraine. The most famous of these allergens group is the pollen of ambrosia and pollen of poaceae, which are ubiquitously distributed in the subtropical and temperate climate. The aim: The objective of our study was to develop the mathematical models, which will be able to indicate the probability of the pollen circulation, and thus these models can simplify the forecast of symptoms risk and improve the prophylaxis of pollinosis...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29775226/moxibustion-for-cephalic-version-of-breech-presentation
#19
REVIEW
Judith M Schlaeger, Cynthia L Stoffel, Jeanie L Bussell, Hui Yan Cai, Miho Takayama, Hiroyoshi Yajima, Nobuari Takakura
Moxibustion, a form of traditional Chinese medicine (TCM), is the burning of the herb moxa (Folium Artemisiae argyi or mugwort) over acupuncture points. It is often used in China to facilitate cephalic version of breech presentation. This article reviews the history, philosophy, therapeutic use, possible mechanisms of action, and literature pertaining to its use for this indication. For moxibustion, moxa can be rolled into stick form, placed directly on the skin, or placed on an acupuncture needle and ignited to warm acupuncture points...
May 18, 2018: Journal of Midwifery & Women's Health
https://www.readbyqxmd.com/read/29772115/phenolic-profile-of-artemisia-alba-turra
#20
Antoaneta Trendafilova, Milka Todorova, Victoria Genova, Samuel Peter, Evelyn Wolfram, Kalina Danova, Luba Evstatieva
The aim of this study was to evaluate flower and leaf methanol extracts of A. alba Turra for their total phenolic and flavonoid contents, antioxidant capacity and to investigate their phenolic composition. The flower extract was richer in total phenolics and flavonoids and possessed higher antioxidant activity through DPPH and ABTS assays. The UHPLC-PDA-MS analysis of the flower and leaf methanol extracts revealed similar phenolic profile and allowed identification of 31 phenolic compounds (flavonoids, coumarins and phenolic acids) by comparison with the respective reference compounds or tentatively characterized by their chromatographic behavior, UV patterns and MS fragmentations...
May 17, 2018: Chemistry & Biodiversity
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