keyword
https://read.qxmd.com/read/37589630/improving-certified-registered-nurse-anesthetists-adherence-to-a-standardized-intraoperative-lung-protective-ventilation-protocol
#21
JOURNAL ARTICLE
Megan G Wilson, Cara N Adams, Matthew D Turnbull, Christian R Falyar, Erica M Harris, Julie A Thompson, Virginia C Simmons
PURPOSE: The use of lung protective ventilation (LPV) during general anesthesia is an effective strategy among certified registered nurse anesthetists (CRNAs) to reduce and prevent the incidence of postoperative pulmonary complications. The purpose of this project was to implement a LPV protocol, assess CRNA provider adherence, and investigate differences in ventilation parameters and postoperative oxygen requirements. DESIGN: This quality improvement project was conducted using a pre- and postimplementation design...
August 17, 2023: Journal of Perianesthesia Nursing: Official Journal of the American Society of PeriAnesthesia Nurses
https://read.qxmd.com/read/37556420/the-impact-of-prescription-drug-insurance-on-cost-related-non-adherence-to-medications-in-canada-a-heckman-sample-selection-approach
#22
JOURNAL ARTICLE
Qi Zhang, Audrey Laporte
Unlike some other high-income counties, Canada does not provide universal prescription drug coverage. The various extent of coverage may left some Canadians vulnerable to cost-related non-adherence (CRNA) to medications. Using data from the 2015 national cycle of the Canadian Community Health Survey, we examine the impact of having private and public drug coverage on mitigating the risk of CRNA with a logit model and a Heckman selection model. CRNA was only observed in respondents who had prescriptions to fill, and respondents did not randomly make decisions on whether to get a prescription...
2023: PloS One
https://read.qxmd.com/read/37525780/the-role-of-liquid-biopsy-in-the-diagnosis-and-prognosis-of-who-grade-4-astrocytoma
#23
REVIEW
Taher Halawa, Saleh Baeesa, Motaz M Fadul, Adnan A Badahdah, Maryam Enani, Amany A Fathaddin, Dania Kawass, Alaa Alkhotani, Basem Bahakeem, Maher Kurdi
Liquid biopsy, as a non-invasive diagnostic tool, has recently gained significant attention in the field of oncology. It involves the analysis of various biomarkers present in bodily fluids, such as blood or cerebrospinal fluid, to provide information about the underlying cancer. In the case of WHO grade 4 astrocytomas, liquid biopsy has the potential to significantly impact the diagnosis and prognosis of this aggressive malignant brain tumor. By detecting specific genetic mutations, such as IDH1 or EGFR, and monitoring levels of circulating tumor DNA, liquid biopsy can aid in the early detection and monitoring of disease progression...
June 2023: Curēus
https://read.qxmd.com/read/37509867/black-queens-of-fruits-chemical-composition-of-blackberry-rubus-subg-rubus-watson-and-black-currant-ribes-nigrum-l-cultivars-selected-in-serbia
#24
JOURNAL ARTICLE
Zaklina Karaklajic-Stajic, Jelena Tomic, Marijana Pesakovic, Svetlana M Paunovic, Franci Stampar, Maja Mikulic-Petkovsek, Mariana C Grohar, Metka Hudina, Jerneja Jakopic
Black fruits, especially blackberries and black currants, are highly appreciated by consumers due to their nutraceutical properties, which have reported health benefits. This study aimed to assess the fruit quality of the blackberry (cv. 'Čačanska Bestrna') and black currant (cv. 'Čačanska Crna') created at the Fruit Research Institute, Čačak (Republic of Serbia) by evaluating basic quality parameters (fruit weight, soluble solids), and content of primary (sugars and organic acids) and secondary (phenolic compounds) metabolites...
July 21, 2023: Foods (Basel, Switzerland)
https://read.qxmd.com/read/37473732/siftcell-a-robust-framework-to-detect-and-isolate-cell-containing-droplets-from-single-cell-rna-sequence-reads
#25
JOURNAL ARTICLE
Jingyue Xi, Sung Rye Park, Jun Hee Lee, Hyun Min Kang
Single-cell RNA sequencing (scRNA-seq) massively profiles transcriptomes of individual cells encapsulated in barcoded droplets in parallel. However, in real-world scRNA-seq data, many barcoded droplets do not contain cells, but instead, they capture a fraction of ambient RNAs released from damaged or lysed cells. A typical first step to analyze scRNA-seq data is to filter out cell-free droplets and isolate cell-containing droplets, but distinguishing them is often challenging; incorrect filtering may mislead the downstream analysis substantially...
July 19, 2023: Cell Systems
https://read.qxmd.com/read/37392567/sodium-taurocholate-hydrate-inhibits-influenza-virus-replication-and-suppresses-influenza-a-virus-triggered-inflammation-in-vitro-and-in-vivo
#26
JOURNAL ARTICLE
Xiaolu Sun, Xiaotong Hu, Qiang Zhang, Li Zhao, Xiaomei Sun, Li Yang, Meilin Jin
Influenza A virus is an important respiratory pathogen that poses serious threats to human health. Owing to the high mutation rate of viral genes, weaker cross-protection of vaccines, and rapid emergence of drug resistance, there is an urgent need to develop new antiviral drugs against influenza viruses. Taurocholic acid is a primary bile acid that promotes digestion, absorption, and excretion of dietary lipids. Here, we demonstrate that sodium taurocholate hydrate (STH) exhibits broad-spectrum antiviral activity against influenza strains H5N6, H1N1, H3N2, H5N1, and H9N2 in vitro...
June 29, 2023: International Immunopharmacology
https://read.qxmd.com/read/37378450/cost-related-prescription-non-adherence-and-patient-reported-outcomes-in-systemic-lupus-erythematosus-the-michigan-lupus-epidemiology-surveillance-program
#27
JOURNAL ARTICLE
Deeba Minhas, Wendy Marder, Afton L Hassett, Suzanna M Zick, Caroline Gordon, Sioban D Harlow, Lu Wang, Kamil E Barbour, Charles G Helmick, W Joseph McCune, Emily C Somers
OBJECTIVES: Medication access and adherence play key roles in determining patient outcomes. We investigated whether cost-related non-adherence (CRNA) to prescription medications was associated with worse patient-reported outcomes in a population-based systemic lupus erythematosus (SLE) cohort. METHODS: Sociodemographic and prescription data were collected by structured interviews in 2014-2015 from patients meeting SLE criteria in the established Michigan Lupus Epidemiology & Surveillance (MILES) Cohort...
June 28, 2023: Lupus
https://read.qxmd.com/read/37358404/etv5a-suppresses-neural-progenitor-cell-proliferation-by-inhibiting-sox2-transcription
#28
JOURNAL ARTICLE
Hung-Yu Shih, Hao-Yuan Chen, Yin-Cheng Huang, Tu-Hsueh Yeh, Yi-Chieh Chen, Yi-Chuan Cheng
Neural progenitor cells are self-renewable, proliferative, and multipotent cell populations that generate diverse types of neurons and glia to build the nervous system. Transcription factors play critical roles in regulating various cellular processes; however, the transcription factors that regulate the development of neural progenitors are yet to be identified. In the present study, we demonstrated that zebrafish etv5a is expressed in the neural progenitor cells of the neuroectoderm. Downregulation of endogenous Etv5a function by etv5a morpholino or an etv5a dominant-negative variant increased the proliferation of sox2-positive neural progenitor cells, accompanied by inhibition of neurogenesis and gliogenesis...
June 26, 2023: Stem Cells and Development
https://read.qxmd.com/read/37334967/biallelic-variants-in-mad2l1bp-p31-comet-cause-female-infertility-characterized-by-oocyte-maturation-arrest
#29
JOURNAL ARTICLE
Lingli Huang, Wenqing Li, Xingxing Dai, Shuai Zhao, Bo Xu, Fengsong Wang, Ren-Tao Jin, Lihua Luo, Liming Wu, Xue Jiang, Yu Cheng, Jiaqi Zou, Caoling Xu, Xianhong Tong, Heng-Yu Fan, Han Zhao, Jianqiang Bao
Human oocyte maturation arrest represents one of the severe conditions for female patients with primary infertility. However, the genetic factors underlying this human disease remain largely unknown. The spindle assembly checkpoint (SAC) is an intricate surveillance mechanism that ensures accurate segregation of chromosomes throughout cell cycles. Once the kinetochores of chromosomes are correctly attached to bipolar spindles and the SAC is satisfied, the MAD2L1BP, best known as p31comet , binds MAD2 and recruits the AAA+-ATPase TRIP13 to disassemble the mitotic checkpoint complex (MCC), leading to the cell cycle progression...
June 19, 2023: ELife
https://read.qxmd.com/read/37291539/operationalizing-risk-appropriate-perinatal-care-in-a-rural-us-state-directions-for-policy-and-practice
#30
JOURNAL ARTICLE
Carly Holman, Annie Glover, Kaitlin Fertaly, Megan Nelson
BACKGROUND: Risk-appropriate care improves outcomes by ensuring birthing people and infants receive care at a facility prepared to meet their needs. Perinatal regionalization has particular importance in rural areas where pregnant people might not live in a community with a birthing facility or specialty care. Limited research focuses on operationalizing risk-appropriate care in rural and remote settings. Through the implementation of the Centers for Disease Control and Prevention (CDC) Levels of Care Assessment Tool (LOCATe), this study assessed the system of risk-appropriate perinatal care in Montana...
June 8, 2023: BMC Health Services Research
https://read.qxmd.com/read/37288167/transcriptomics-for-clinical-and-experimental-biology-research-hang-on-a-seq
#31
REVIEW
Tanner Stokes, Haoning Howard Cen, Philipp Kapranov, Iain J Gallagher, Andrew A Pitsillides, Claude-Henry Volmar, William E Kraus, James D Johnson, Stuart M Phillips, Claes Wahlestedt, James A Timmons
Sequencing the human genome empowers translational medicine, facilitating transcriptome-wide molecular diagnosis, pathway biology, and drug repositioning. Initially, microarrays are used to study the bulk transcriptome; but now short-read RNA sequencing (RNA-seq) predominates. Positioned as a superior technology, that makes the discovery of novel transcripts routine, most RNA-seq analyses are in fact modeled on the known transcriptome. Limitations of the RNA-seq methodology have emerged, while the design of, and the analysis strategies applied to, arrays have matured...
June 2023: Advanced genetics
https://read.qxmd.com/read/37240348/carrier-mediated-process-of-putrescine-elimination-at-the-rat-blood-retinal-barrier
#32
JOURNAL ARTICLE
Yuma Tega, Yoshiyuki Kubo, Hiroaki Miura, Kairi Ri, Ayaka Tomise, Shin-Ichi Akanuma, Ken-Ichi Hosoya
Putrescine is a bioactive polyamine. Its retinal concentration is strictly controlled to maintain a healthy sense of vision. The present study investigated putrescine transport at the blood-retinal barrier (BRB) to gain a better understanding of the mechanisms of putrescine regulation in the retina. Our microdialysis study showed that the elimination rate constant during the terminal phase was significantly greater (1.90-fold) than that of [14 C]D-mannitol, which is a bulk flow marker. The difference in the apparent elimination rate constants of [3 H]putrescine and [14 C]D-mannitol was significantly decreased by unlabeled putrescine and spermine, suggesting active putrescine transport from the retina to the blood across the BRB...
May 19, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37227960/examination-of-a-nurse-anesthesia-program-s-teaching-assistant-model-and-its-impact-on-increasing-nurse-anesthesia-education-capacity
#33
JOURNAL ARTICLE
Olivia Baker, Hannah Sparks, Carrie Bowman Dalley, Marjorie Everson, Nancy Crowell, Ladan Eshkevari
A nurse anesthesia educator shortage exists that is attributed to factors such as a lack of financial incentive and proper training to be an educator. Due to the faculty shortage, nurse anesthesia programs (NAPs) are forced to defer admission to qualified applicants which reduces the number of certified registered nurse anesthetists (CRNAs) that NAPs can produce. Research regarding students as teaching assistants (TAs) at the university level has shown benefits and challenges to students, professors, and the TAs themselves as well as the impact on the overall faculty capacity...
June 2023: AANA Journal
https://read.qxmd.com/read/37212058/exonic-genetic-variants-associated-with-unexpected-fertilization-failure-and-zygotic-arrest-after-icsi-a-systematic-review
#34
REVIEW
Marc Torra-Massana, Amelia Rodríguez, Rita Vassena
Fertilization failure (FF) and zygotic arrest after ICSI have a huge effect on both patients and clinicians, but both problems are usually unexpected and cannot be properly diagnosed. Fortunately, in recent years, gene sequencing has allowed the identification of multiple genetic variants underlying failed ICSI outcomes, but the use of this approach is still far from routine in the fertility clinic. In this systematic review, the genetic variants associated with FF, abnormal fertilization and/or zygotic arrest after ICSI are compiled and analyzed...
May 22, 2023: Zygote: the Biology of Gametes and Early Embryos
https://read.qxmd.com/read/37166301/fine-regulation-of-influenza-virus-rna-transcription-and-replication-by-stoichiometric-changes-in-viral-ns1-and-ns2-proteins
#35
JOURNAL ARTICLE
Lei Zhang, Yingying Wang, Yuekun Shao, Jiamei Guo, George F Gao, Tao Deng
In the influenza virus life cycle, viral RNA (vRNA) transcription (vRNA→mRNA) and replication (vRNA→cRNA→vRNA), catalyzed by the viral RNA-dependent RNA polymerase in the host cell nucleus, are delicately controlled, and the levels of the three viral RNA species display very distinct synthesis dynamics. However, the underlying mechanisms remain elusive. Here, we demonstrate that in the context of virus infection with cycloheximide treatment, the expression of viral nonstructural protein 1 (NS1) can stimulate primary transcription, while the expression of viral NS2 inhibits primary transcription...
May 11, 2023: Journal of Virology
https://read.qxmd.com/read/37120635/phosphorylation-of-the-pa-subunit-of-influenza-polymerase-at-y393-prevents-binding-of-the-5-termini-of-rna-and-polymerase-function
#36
JOURNAL ARTICLE
Lu Liu, Ramakanth Madhugiri, Vera Vivian Saul, Susanne Bacher, Michael Kracht, Stephan Pleschka, M Lienhard Schmitz
The influenza A virus (IAV) polymerase is a multifunctional machine that can adopt alternative configurations to perform transcription and replication of the viral RNA genome in a temporally ordered manner. Although the structure of polymerase is well understood, our knowledge of its regulation by phosphorylation is still incomplete. The heterotrimeric polymerase can be regulated by posttranslational modifications, but the endogenously occurring phosphorylations at the PA and PB2 subunits of the IAV polymerase have not been studied...
April 29, 2023: Scientific Reports
https://read.qxmd.com/read/37069509/application-of-sequence-semantic-and-integrated-cellular-geography-approach-to-study-alternative-biogenesis-of-exonic-circular-rna
#37
JOURNAL ARTICLE
Rajnish Kumar, Rajkrishna Mondal, Tapobrata Lahiri, Manoj Kumar Pal
BACKGROUND: Concurrent existence of lncRNA and circular RNA at both nucleus and cytosol within a cell at different proportions is well reported. Previous studies showed that circular RNAs are synthesized in nucleus followed by transportation across the nuclear membrane and the export is primarily defined by their length. lncRNAs primarily originated through inefficient splicing and seem to use NXF1 for cytoplasm export. However, it is not clear whether circularization of lncRNA happens only in nucleus or it also occurs in cytoplasm...
April 17, 2023: BMC Bioinformatics
https://read.qxmd.com/read/36972224/syntheses-characterizations-crystal-structures-and-protonation-reactions-of-dinitrogen-chromium-complexes-supported-with-triamidoamine-ligands
#38
JOURNAL ARTICLE
Yoshiaki Kokubo, Kazuki Tsuzuki, Hikari Sugiura, Shunsuke Yomura, Yuko Wasada-Tsutsui, Tomohiro Ozawa, Sachiko Yanagisawa, Minoru Kubo, Tomoyuki Takeyama, Takahide Yamaguchi, Yuichi Shimazaki, Shinichi Kugimiya, Hideki Masuda, Yuji Kajita
A novel dinitrogen-dichromium complex, [{Cr( LBn )}2 (μ-N2 )] ( 1 ), has been prepared from reaction of CrCl3 with a lithiated triamidoamine ligand ( Li3 LBn ) under dinitrogen. The X-ray crystal structure analysis of 1 revealed that it is composed of two independent dimeric Cr complexes bridged by N2 in the unit cell. The bridged N-N bond lengths (1.188(4) and 1.185(7) Å) were longer than the free dinitrogen molecule. The elongations of N-N bonds in 1 were also supported by the fact that the ν(N-N) stretching vibration at 1772 cm-1 observed in toluene is smaller than the free N2 ...
March 27, 2023: Inorganic Chemistry
https://read.qxmd.com/read/36951844/called-to-lead-a-qualitative-examination-of-the-experiences-and-contributions-of-certified-registered-nurse-anesthetists-during-the-covid-19-pandemic-response-in-the-united-states
#39
JOURNAL ARTICLE
Mitchell Kraus, Emma Montague, Susan Krawczyk, Shannon D Simonovich
The COVID-19 pandemic strained healthcare providers, particularly certified registered nurse anesthetists (CRNAs). To date, little research has focused on the effects of the COVID-19 pandemic on CRNAs, whose unique skillset conferred on them expanded roles and responsibilities, increasing their stress load. Therefore, the purpose of this study was to utilize qualitative descriptive methodology to examine the experiences of CRNAs during the COVID-19 pandemic. Twelve CRNAs providing patient care in the US during the COVID-19 pandemic completed the interview protocol...
April 2023: AANA Journal
https://read.qxmd.com/read/36898499/the-utility-of-zebrafish-cardiac-arrhythmia-model-to-predict-the-pathogenicity-of-kcnq1-variants
#40
JOURNAL ARTICLE
Shihe Cui, Kenshi Hayashi, Isao Kobayashi, Kazuyoshi Hosomichi, Akihiro Nomura, Ryota Teramoto, Keisuke Usuda, Hirofumi Okada, Yaowen Deng, Jingjing Kobayashi-Sun, Tetsuo Nishikawa, Hiroshi Furusho, Takekatsu Saito, Hiroaki Hirase, Kunio Ohta, Manabu Fujimoto, Yuki Horita, Takashi Kusayama, Toyonobu Tsuda, Hayato Tada, Takeshi Kato, Soichiro Usui, Kenji Sakata, Noboru Fujino, Atsushi Tajima, Masakazu Yamagishi, Masayuki Takamura
Genetic testing for inherited arrhythmias and discriminating pathogenic or benign variants from variants of unknown significance (VUS) is essential for gene-based medicine. KCNQ1 is a causative gene of type 1 long QT syndrome (LQTS), and approximately 30% of the variants found in type 1 LQTS are classified as VUS. We studied the role of zebrafish cardiac arrhythmia model in determining the clinical significance of KCNQ1 variants. We generated homozygous kcnq1 deletion zebrafish (kcnq1del/del ) using the CRISPR/Cas9 and expressed human Kv7...
March 8, 2023: Journal of Molecular and Cellular Cardiology
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