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https://www.readbyqxmd.com/read/28722515/construction-of-a-plga-based-targeted-sirna-delivery-system-for-treatment-of-osteoporosis
#1
Deniz Sezlev Bilecen, Jose Carlos Rodriguez-Cabello, Hasan Uludag, Vasif Hasirci
Osteoporosis is a systemic skeletal disorder which occurs when the bone turnover balance is disrupted. With the identification of the genes involved in the pathogenesis of the disease, studies on development of new osteoporosis treatments has intensified. RNA interference (RNAi) mechanism uses short interfering RNA (siRNA) to knockdown disease related gene expression as a treatment approach. Targeting while protecting siRNA against hydrolysis by nucleases in vivo is, however, challenging. The maintenance of therapeutic plasma level is also hampered by the clearance of siRNA from the body...
July 19, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28719196/thermoresponsive-elastin-b-collagen-like-peptide-bioconjugate-nanovesicles-for-targeted-drug-delivery-to-collagen-containing-matrices
#2
Tianzhi Luo, Michael A David, Lucas C Dunshee, Rebecca A Scott, Morgan A Urello, Christopher Price, Kristi L Kiick
Over the past few decades, (poly)peptide block copolymers have been widely employed in generating well-defined nanostructures as vehicles for targeted drug delivery applications. We previously reported the assembly of thermoresponsive nanovesicles from an elastin-b-collagen like peptide (ELP-CLP). The nanoparticles were observed to dissociate at elevated temperatures, despite the LCST-like behavior of the tethered ELP domain, which is suggested to be triggered by the unfolding of the CLP domain. Here, the potential of using the nanoparticles as drug delivery vehicles for targeting collagen-containing matrices is evaluated...
July 18, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28716438/the-impact-of-knowledge-transfer-on-the-detection-of-venous-invasion-in-colorectal-cancer
#3
Richard Kirsch, Naziheh Assarzadegan, David E Messenger, Ari Juda, Robert H Riddell, Aaron Pollett, Catherine J Streutker, Dimitrios X Divaris, Ken J Newell, Russell G Price, Sharyn Smith, Sahar Al-Haddad, Jeremy R Parfitt, David K Driman
Venous invasion (VI) is an independent predictor of hematogenous metastasis and mortality in colorectal cancer (CRC), yet remains widely under-reported. Its detection may require recognition of subtle morphologic clues which at times are only unmasked with an elastin stain. This study evaluates the impact of a knowledge transfer initiative (KTI) on VI detection in a "real world" pathology practice setting. Following participation in an interobserver variability study of VI detection (Kirsch et al 2013), twelve participants received educational materials highlighting key issues in VI detection...
July 14, 2017: Human Pathology
https://www.readbyqxmd.com/read/28715511/endovascular-treatment-of-genetically-linked-aortic-diseases
#4
D Böckler, K Meisenbacher, A S Peters, C Grond-Ginsbach, M S Bischoff
BACKGROUND: The most important structural proteins of the vascular wall are collagen and elastin. Genetically linked connective tissue diseases lead to degeneration, aneurysm formation and spontaneous dissection or rupture of arteries. The most well-known are Marfan syndrome, vascular Ehlers-Danlos syndrome (type IV), Loeys-Dietz syndrome and familial aortic aneurysms and dissections. OBJECTIVE: This review article addresses the current status of endovascular treatment options for important connective tissue diseases...
2017: Gefässchirurgie: Zeitschrift Für Vaskuläre und Endovaskuläre Chirurgie
https://www.readbyqxmd.com/read/28715234/is-cardiovascular-disease-in-patients-with-diabetes-associated-with-serum-levels-of-mmp-2-lox-and-the-elastin-degradation-products-elm-and-elm-2
#5
Simone Andrea Rørdam Preil, Anne-Sofie Faarvang Thorsen, Anne Lindegaard Christiansen, Mikael Kjær Poulsen, Morten Asser Karsdal, Diana Julie Leeming, Lars Melholt Rasmussen
BACKGROUND: Diabetes mellitus type 2 (T2DM) is a significant risk factor for the development of cardiovascular diseases (CVDs). In a previous microarray study of internal mammary arteries from patients with and without T2DM, we observed several elastin-related genes with altered mRNA-expression in diabetic patients, namely matrix metalloproteinase 2 (MMP-2), lysyl oxidase (LOX) and elastin itself. In this study we investigate whether the serum concentrations of elastin-related proteins correlate to signs of CVD in patients with T2DM...
July 17, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/28714016/elastin%C3%A2-derived-peptides-are-involved-in-the-processes-of-human-temporomandibular-disorder-by-inducing-inflammatory-responses-in-synovial-cells
#6
Kazuhiko Kobayashi, Rei Jokaji, Mayuko Miyazawa-Hira, Shigeyuki Takatsuka, Akira Tanaka, Kazuhiro Ooi, Hiroyuki Nakamura, Shuichi Kawashiri
Temporomandibular joint dysfunction (TMD) is a collection of clinical symptoms that involve masticatory muscles and the temporomandibular joint (TMJ). Common symptoms include limited jaw motion and joint sound/pain, along with TMJ disc displacement. TMD is frequently associated with synovitis, a chronic inflammation of the synovium. Fibroblast‑like synovial cells have been identified to produce several inflammatory mediators and may have an important role in the progression of TMJ inflammation. Degradation of the extracellular matrix molecule elastin may lead to the release of bioactive peptides...
July 15, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28711328/overexpression-of-microrna-30a-contributes-to-the-development-of-aortic-dissection-by-targeting-lysyl-oxidase
#7
Yang Yu, Enyi Shi, Tianxiang Gu, Rui Tang, Shilun Gao, Yongchao Wang, Hongbo Liu
OBJECTIVE: To explore the role of microRNA (miR)-30a in the development of aortic dissection. METHODS: Human aortic specimens of aortic dissections and aneurysms were harvested. Aortic specimens from donors for heart transplantation served as controls. Rat aortic vascular smooth muscle cells (VSMCs) were transfected with agomiR-30a or antagomiR-30a, and control cells were incubated with empty vectors. Rats were pretreated with agomiR-30a or antagomiR-30a (5 × 10(7) transfection units every 3 days for 4 weeks), and empty vectors were infused to controls...
June 16, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28711025/three-dimensional-mechano-electrochemical-model-for-smooth-muscle-contraction-of-the-urinary-bladder
#8
Robert Seydewitz, Robin Menzel, Tobias Siebert, Markus Böl
The urinary bladder is a central organ of vertebrates and imposes, based on its extreme deformation (volume changes up to several 100%), special requirements on the overall bladder tissue. However, studies focusing on three-dimensional modelling of bladder deformation and bladder function during micturition are rare. Based on three fields, namely, the membrane potential, calcium concentration, and placement, a mechano-electrochemical-coupled, three-dimensional model describing the contractile behaviour of urinary bladder smooth muscle is presented using a strain energy function...
April 12, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28702876/cardiovascular-histopathology-of-a-11-year-old-with-mucopolysaccharidosis-vii-demonstrates-fibrosis-macrophage-infiltration-and-arterial-luminal-stenosis
#9
Valerie Lew, Louis Pena, Robert Edwards, Raymond Y Wang
Mucopolysaccharidosis type VII (MPS VII) is caused by β-glucuronidase deficiency, resulting in lysosomal accumulation of glycosaminoglycans (GAGs) and multisystemic disease. We present cardiovascular gross and histopathology findings from a 11-year-old MPS VII male, who expired after developing ventricular fibrillation following anesthesia induction. Gross anatomic observations were made at autopsy; postmortem formalin-fixed paraffin-embedded samples of the carotid artery, aorta, myocardium, and valves were sectioned and stained with hematoxylin-eosin, Verhoeff-Van Gieson, CD68, and trichrome stains...
July 13, 2017: JIMD Reports
https://www.readbyqxmd.com/read/28701001/downregulated-elastin-microfibril-interfacer-1-expression-in-the-pulmonary-vasculature-of-experimental-congenital-diaphragmatic-hernia
#10
Julia Zimmer, Toshiaki Takahashi, Alejandro D Hofmann, Prem Puri
No abstract text is available yet for this article.
July 12, 2017: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28698228/perturbations-to-lysyl-oxidase-expression-broadly-influence-the-transcriptome-of-lung-fibroblasts
#11
Ivana Mižíková, Francesco Palumbo, Tamás Tábi, Susanne Herold, István Vadász, Konstantin Mayer, Werner Seeger, Rory E Morty
Lysyl oxidases are credited with pathogenic roles in lung diseases, including cancer, fibrosis, pulmonary hypertension, congenital diaphragmatic hernia, and bronchopulmonary dysplasia (BPD). Lysyl oxidases facilitate the covalent intra- and inter-molecular cross-linking of collagen and elastin fibers, thereby imparting tensile strength to the extracellular matrix (ECM). Alternative ECM-independent roles have recently been proposed for lysyl oxidases, including regulation of growth factor signaling, chromatin remodeling, and transcriptional regulation; all of which impact cell phenotype...
July 10, 2017: Physiological Genomics
https://www.readbyqxmd.com/read/28693818/arterial-wall-remodeling-under-sustained-axial-twisting-in-rats
#12
Guo-Liang Wang, Li-Yi Wang, Shao-Xiong Yang, Ping Zhang, Xiao-Hu Chen, Qing-Ping Yao, Xiao-Bo Gong, Ying-Xin Qi, Zong-Lai Jiang, Hai-Chao Han
Blood vessels often experience torsion along their axes and it is essential to understand their biological responses and wall remodeling under torsion. To this end, a rat model was developed to investigate the arterial wall remodeling under sustained axial twisting in vivo. Rat carotid arteries were twisted at 180° along the longitudinal axis through a surgical procedure and maintained for different durations up to 4weeks. The wall remodeling in these twisted arteries was examined using histology, immunohistochemistry and fluorescent microscopy...
June 21, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28691479/effect-of-platelet-reach-plasma-on-fibroblast-primary-culture-gene-expression-evaluation
#13
V Candotto, A Palmieri, F Cura, F J Silvestre, D Lauritano, R M Gaudio, A Baj, A B Giannì
To correct skin imperfections, aesthetic medicine today makes use of injectable dermal fillers that allow filling skin by increasing the volume of soft tissue. Currently, there are many fillers usable for their excellent biocompatibility and low allergic reactions that ensure good results and good compliance. Among these, the most widely used filler is Human Plasma, obtained by centrifugation from patient blood and processed through cycles of centrifugation and heating, until it becomes a gel. In this work, we evaluated the effect of the Plasma on fibroblasts behavior in terms of cell viability, survival, growth and collagen production...
April 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28691460/the-%C3%A2-elfin-face%C3%A2-craniofacial-and-dental-aspects-of-the-williams-beuren-syndrome
#14
V Maurino, L Azzi, R Vinci, F Croveri, A Boggio, J Silvestre-Rangil, L Tettamanti, A Tagliabue
Williams Syndrome is a rare congenital disorder characterized by supravalvular aortic stenosis, peripheral pulmonary artery stenosis, mental retard and dysmorfic facial features. As regards the dental aspects of the syndrome, the deletion of the elastin gene induced clinicians to suspect periodontal alterations with a greater frequency of gingivo-periodontitis, but on the contrary no association between the syndrome and periodontal diseases have been found. Furthermore, patients show a higher frequency of teeth hypoplasia, an abnormal tooth morphology during primary dentition (12...
April 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28690007/bioreactor-induced-mesenchymal-progenitor-cell-differentiation-and-elastic-fiber-assembly-in-engineered-vascular-tissues
#15
Shigang Lin, Kibret Mequanint
In vitro maturation of engineered vascular tissues (EVT) requires the appropriate incorporation of smooth muscle cells (SMC) and extracellular matrix (ECM) components similar to native arteries. To this end, the aim of the current study was to fabricate 4 mm inner diameter vascular tissues using mesenchymal progenitor cells seeded into tubular scaffolds. A dual-pump bioreactor operating either in perfusion or pulsatile perfusion mode was used to generate physiological-like stimuli to promote progenitor cell differentiation, extracellular elastin production, and tissue maturation...
July 6, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28688286/co-delivery-of-a-growth-factor-and-a-tissue-protective-molecule-using-elastin-biopolymers-accelerates-wound-healing-in-diabetic-mice
#16
Julie Devalliere, Kevin Dooley, Yong Yu, Sarah S Kelangi, Basak E Uygun, Martin L Yarmush
Growth factor therapy is a promising approach for chronic diabetic wounds, but strategies to efficiently and cost-effectively deliver active molecules to the highly proteolytic wound environment remain as major obstacles. Here, we re-engineered keratinocyte growth factor (KGF) and the cellular protective peptide ARA290 into a protein polymer suspension with the purpose of increasing their proteolytic resistance, thus their activity in vivo. KGF and ARA290 were fused with elastin-like peptide (ELP), a protein polymer derived from tropoelastin, that confers the ability to separate into a colloidal suspension of liquid-like coacervates...
June 30, 2017: Biomaterials
https://www.readbyqxmd.com/read/28686242/keratin-dissolution-extraction-and-biomedical-application
#17
REVIEW
Amin Shavandi, Tiago H Silva, Adnan A Bekhit, Alaa El-Din A Bekhit
Keratinous materials such as wool, feathers and hooves are tough unique biological co-products that usually have high sulfur and protein contents. A high cystine content (7-13%) differentiates keratins from other structural proteins, such as collagen and elastin. Dissolution and extraction of keratin is a difficult process compared to other natural polymers, such as chitosan, starch, collagen, and a large-scale use of keratin depends on employing a relatively fast, cost-effective and time efficient extraction method...
July 7, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28681841/recombinant-elastin-based-nanoparticles-for-targeted-gene-therapy
#18
D A Monfort, P Koria
Among viruses, lentiviral vectors have been popular vectors for gene delivery due to their efficient mode of gene delivery. However, the non-specific delivery of genes associated with lentiviral vectors may result in undesirable side effects. Here, we propose a heterogeneous nanoparticle delivery system for targeted delivery of lentiviral particles containing a therapeutic gene. The heterogeneous nanoparticles consist of the low density lipoprotein receptor 3 (LDLR3) and the keratinocyte growth factor (KGF), each fused to elastin-like-polypeptides (ELPs), LDLR3-ELP and KGF-ELP, respectively...
July 5, 2017: Gene Therapy
https://www.readbyqxmd.com/read/28681273/delayed-symptomatic-haemorrhage-from-the-remnants-of-a-thalamic-arteriovenous-malformation-after-previous-angiographic-cure-with-radiotherapy
#19
Paulina Majewska, Alpha Tsui, Alexios A Adamides
In 1995 a 16-year old girl was diagnosed with a large left thalamic AVM that was considered unsuitable for microsurgical resection and was treated with radiotherapy twice, which led to angiographic cure. She re-presented 19 years after initial treatment with a symptomatic acute thalamic haemorrhage. Her digital subtraction angiography was negative for arterio-venous shunting. MRI/MRA showed cystic change with adjacent contrast enhancement in the region of the previously irradiated arteriovenous malformation...
July 5, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28676156/anatomy-of-the-skin-and-the-pathogenesis-of-nonmelanoma-skin-cancer
#20
REVIEW
William D Losquadro
Skin is composed of the epidermis, dermis, and adnexal structures. The epidermis is composed of 4 layers-the stratums basale, spinosum, granulosum, and corneum. The dermis is divided into a superficial papillary dermis and deeper reticular dermis. Collagen and elastin within the reticular dermis are responsible for skin tensile strength and elasticity, respectively. The 2 most common kinds of nonmelanoma skin cancers are basal cell and squamous cell carcinoma. Both are caused by a host of environmental and genetic factors, although UV light exposure is the single greatest predisposing factor...
August 2017: Facial Plastic Surgery Clinics of North America
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