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https://www.readbyqxmd.com/read/28087488/cathepsin-k-targeted-sub-micron-particles-for-regenerative-repair-of-vascular-elastic-matrix
#1
Brenton Jennewine, Jonathan Fox, Anand Ramamurthi
: Abdominal Aortic Aneurysms (AAA) involve slow dilation and weakening of the aortic wall due to breakdown of structural matrix components, such as elastic fibers by chronically overexpressed matrix metalloproteinases (MMPs), primarily, MMPs-2 and -9. Auto-regenerative repair of disrupted elastic fibers by smooth muscle cells (SMCs) at the AAA site is intrinsically poor and together with chronic proteolysis prevents restoration of elastin homeostasis, necessary to enable AAA growth arrest or regression to a healthy state...
January 10, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28075561/selective-tuning-of-elastin-like-polypeptide-properties-via-methionine-oxidation
#2
Rosine Petitdemange, Elisabeth Garanger, Laure Bataille, Katell Bathany, Bertrand Garbay, Timothy J Deming, Sebastien Lecommandoux
We have designed and prepared a recombinant elastin-like polypeptide (ELP) containing precisely positioned methionine residues, and performed the selective and complete oxidation of its methionine thioether groups to both sulfoxide and sulfone derivatives. Since these oxidation reactions substantially increase methionine residue polarity, they were found to be a useful means to precisely adjust the temperature responsive behavior of ELPs in aqueous solutions. In particular, lower critical solution temperatures were found to be elevated in oxidized sample solutions, but were not eliminated...
January 11, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28074876/scale-up-of-nature-s-tissue-weaving-algorithms-to-engineer-advanced-functional-materials
#3
Joanna L Ng, Lillian E Knothe, Renee M Whan, Ulf Knothe, Melissa L Knothe Tate
We are literally the stuff from which our tissue fabrics and their fibers are woven and spun. The arrangement of collagen, elastin and other structural proteins in space and time embodies our tissues and organs with amazing resilience and multifunctional smart properties. For example, the periosteum, a soft tissue sleeve that envelops all nonarticular bony surfaces of the body, comprises an inherently "smart" material that gives hard bones added strength under high impact loads. Yet a paucity of scalable bottom-up approaches stymies the harnessing of smart tissues' biological, mechanical and organizational detail to create advanced functional materials...
January 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28074631/transdifferentiation-of-human-dermal-fibroblasts-to-smooth-muscle-like-cells-to-study-the-effect-of-myh11-and-acta2-mutations-in-aortic-aneurysms
#4
Kak K Yeung, Natalija Bogunovic, Niels Keekstra, Adriaan A M Beunders, Jorrit Pals, Kim van der Kuij, Eline Overwater, Willem Wisselink, Jan D Blankensteijn, Victor W M van Hinsbergh, Rene J P Musters, Gerard Pals, Dimitra Micha, Behrouz Zandieh-Doulabi
Mutations in genes encoding proteins of the smooth muscle cell (SMC) contractile apparatus contribute to familial aortic aneurysms. To investigate the pathogenicity of these mutations, SMC are required. We demonstrate a novel method to generate SMC-like cells from human dermal fibroblasts by transdifferentiation to study the effect of variants in genes encoding proteins of the SMC contractile apparatus (ACTA2 and MYH11) in patients with aortic aneurysms. Dermal fibroblasts from 7 healthy donors and cells from 7 patients with MYH11 or ACTA2 variants were transdifferentiated into SMC-like cells within a 2 week duration using 5ng/mL TGFβ1 on a scaffold containing collagen and elastin...
January 11, 2017: Human Mutation
https://www.readbyqxmd.com/read/28070887/diversity-in-the-organization-of-elastin-bundles-and-intramembranous-muscles-in-bat-wings
#5
Jorn A Cheney, Justine J Allen, Sharon M Swartz
Unlike birds and insects, bats fly with wings composed of thin skin that envelops the bones of the forelimb and spans the area between the limbs, digits, and sometimes the tail. This skin is complex and unusual; it is thinner than typical mammalian skin and contains organized bundles of elastin and embedded skeletal muscles. These elements are likely responsible for controlling the shape of the wing during flight and contributing to the aerodynamic capabilities of bats. We examined the arrangement of two macroscopic architectural elements in bat wings, elastin bundles and wing membrane muscles, to assess the diversity in bat wing skin morphology...
January 10, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/28062506/wnt-signaling-pathway-inhibitor-sclerostin-inhibits-angiotensin-ii-induced-aortic-aneurysm-and-atherosclerosis
#6
Smriti Murali Krishna, Sai-Wang Seto, Roby J Jose, Jiaze Li, Susan K Morton, Erik Biros, Yutang Wang, Vianne Nsengiyumva, Jan H N Lindeman, Gabriela G Loots, Catherine M Rush, Jeffrey M Craig, Jonathan Golledge
OBJECTIVE: Sclerostin (SOST) has been identified as an important regulator of bone formation; however, it has not been previously implicated in arterial disease. The aim of this study was to assess the role of SOST in aortic aneurysm (AA) and atherosclerosis using human samples, a mouse model, and in vitro investigations. APPROACH AND RESULTS: SOST protein was downregulated in human and mouse AA samples compared with controls. Transgenic introduction of human SOST in apolipoprotein E-deficient (ApoE(-/-)) mice (SOST(Tg)...
December 22, 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28056723/chronic-treatment-with-minoxidil-induces-elastic-fiber-neosynthesis-and-functional-improvement-in-the-aorta-of-aged-mice
#7
Marion Coquand-Gandit, Marie Paule Jacob, Wassim Fhayli, Beatriz Romero Ruiz de la Hermosa, Miglena Georgieva, Stéphanie Bouillot, Eric Estève, Jean-Pierre Andrieu, Sandrine Brasseur, Sophie Bouyon, Natalio Garcia-Honduvilla, Philippe Huber, Julia Bujan, Milena Atanasova, Gilles Faury
Normal arterial aging processes involve vascular cell dysfunction associated with wall stiffening, the latter being due to progressive elastin and elastic fiber degradation, as well as elastin and collagen cross-linking by advanced glycation end-products (AGE). These processes progressively lead to cardiovascular dysfunction during aging. Elastin is only synthesized during late gestation and childhood, and further degradation occurring throughout adulthood cannot be physiologically compensated by replacement of altered material...
January 5, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28054487/guanidinium-can-both-cause-and-prevent-the-hydrophobic-collapse-of-biomacromolecules
#8
Jan Heyda, Halil I Okur, Jana Hladílková, Kelvin B Rembert, William Hunn, Tinglu Yang, Joachim Dzubiella, Pavel Jungwirth, Paul S Cremer
A combination of Fourier transform infrared and phase transition measurements as well as molecular computer simulations, and thermodynamic modeling were performed to probe the mechanisms by which guanidinium (Gnd(+)) salts influence the stability of the collapsed versus uncollapsed state of an elastin-like polypeptide (ELP), an uncharged thermoresponsive polymer. We found that the cation's action was highly dependent upon the counteranion with which it was paired. Specifically, Gnd(+) was depleted from the ELP/water interface and was found to stabilize the collapsed state of the macromolecule when paired with well-hydrated anions such as SO4(2-)...
January 5, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28046760/su-f-t-10-validation-of-elp-dosimetry-using-presage-dosimeter-feasibility-test-and-practical-considerations
#9
K Lambson, K Lafata, J Schaal, D Miles, S Yoon, W Liu, M Oldham, J Cai
PURPOSE: To validate the use of a PRESAGE dosimeter as a method to quantitatively measure dose distributions of injectable brachytherapy based on elastin-like polypeptide (ELP) nanoparticles. PRESAGE is a solid, transparent polyurethane-based dosimeter whose dose is proportional to a change in optical density, making it useful for visualizing the dose from a radionuclide-tagged-ELP injection. METHODS: A PRESAGE dosimeter was designed to simulate an ELP injection...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28038939/skin-fragility-in-the-wild-derived-inbred-mouse-strain-mus-pahari-eij
#10
C Herbert Pratt, Christopher S Potter, Thomas J Sproule, Raoul V Kuiper, Son Yong Karst, Soheil S Dadras, Derry C Roopenian, John P Sundberg
Mus pahari is a wild-derived, inbred mouse strain. M. pahari colony managers observed fragility of this strain's skin resulting in separation of tail skin from the mouse if handled incorrectly. Tail skin tension testing of M. pahari resulted in significantly lowered force threshold for caudal skin rupture and loss in comparison to closely related inbred mouse species and subspecies and even more than a model for junctional epidermolysis bullosa. Histologically, the tail skin separated at the subdermal level with the dermis firmly attached to the epidermis, excluding the epidermolysis bullosa complex of diseases...
December 27, 2016: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28036074/lysyl-oxidase-and-the-tumor-microenvironment
#11
REVIEW
Tong-Hong Wang, Shih-Min Hsia, Tzong-Ming Shieh
The lysyl oxidase (LOX) family of oxidases contains a group of extracellular copper-dependent enzymes that catalyze the cross-linking of collagen and elastin by oxidation, thus maintaining the rigidity and structural stability of the extracellular matrix (ECM). Aberrant expression or activation of LOX alters the cellular microenvironment, leading to many diseases, including atherosclerosis, tissue fibrosis, and cancer. Recently, a number of studies have shown that LOX is overexpressed in most cancers and that it is involved in the regulation of tumor progression and metastasis...
December 29, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28029182/nedd4-deficiency-in-vascular-smooth-muscle-promotes-vascular-calcification-by-stabilizing-psmad1
#12
Ji-Hyun Lee, Seon-Ae Jeon, Byung-Gyu Kim, Michiko Takeda, Jae-Jin Cho, Dong-Ik Kim, Hiroshi Kawabe, Je-Yoel Cho
The nonosseous calcification process such as atherosclerosis is one of the major complications in several types of metabolic diseases. In previous study, we uncovered that aberrant activity of TGF-β signaling pathway could contribute the vascular smooth muscle cells (VSMCs) calcification process. Also, we identified NEDD4 E3 ligase as a key suppressor of BMP/Smad pathway via a polyubiquitination dependent selective degradation of C-terminal phosphorylated Smad1 (pSmad1) activated by TGF-β⋅ Here, we further validated and confirmed the role of Nedd4 in in vivo vascular calcification progression...
December 28, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28025048/tropoelastin-inhibits-intimal-hyperplasia-of-mouse-bioresorbable-arterial-vascular-grafts
#13
Tadahisa Sugiura, Riddhima Agarwal, Shuhei Tara, Tai Yi, Yong-Ung Lee, Christopher K Breuer, Anthony S Weiss, Toshiharu Shinoka
: Neointimal hyperplasia, which results from the activation, proliferation and migration of vascular smooth muscle cells (SMCs), is a detrimental condition for vascular stents or vascular grafts that leads to stenosis. Preventing neointimal hyperplasia of vascular grafts is critically important for the success of arterial vascular grafts. We hypothesized that tropoelastin seeding onto the luminal surface of the graft would prevent neointimal hyperplasia through suppressing neointimal smooth muscle cell proliferation...
December 23, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/28017585/evaluation-of-the-stromal-vascular-fraction-of-adipose-tissue%C3%A2-as-the-basis-for-a-stem-cell-based-tissue-engineered-vascular-graft
#14
Jeffrey T Krawiec, Han-Tsung Liao, LaiYee Lily Kwan, Antonio D'Amore, Justin S Weinbaum, J Peter Rubin, William R Wagner, David A Vorp
OBJECTIVE: One of the rate-limiting barriers within the field of vascular tissue engineering is the lengthy fabrication time associated with expanding appropriate cell types in culture. One particularly attractive cell type for this purpose is the adipose-derived mesenchymal stem cell (AD-MSC), which is abundant and easily harvested from liposuction procedures. Even this cell type has its drawbacks, however, including the required culture period for expansion, which could pose risks of cellular transformation or contamination...
December 22, 2016: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28010122/lysyl-oxidase-induces-vascular-oxidative-stress-and-contributes-to-arterial-stiffness-and-abnormal-elastin-structure-in-hypertension-role-of-p38mapk
#15
Sonia Martínez-Revelles, Ana Belen Garcia-Redondo, Mª Soledad Avendaño, Saray Varona, Teresa Palao, Mar Orriols, Fernanda R Roque, Ana Fortuño, Rhian M Touyz, Jose Martínez-Gonzalez, Mercedes Salaices, Cristina Rodríguez, Ana María Briones
AIMS: Vascular stiffness, structural elastin abnormalities and increased oxidative stress are hallmarks of hypertension. Lysyl oxidase (LOX) is an elastin cross-linking enzyme that produces H<sub>2</sub>O<sub>2</sub> as by-product. We addressed the interplay between LOX, oxidative stress, vessel stiffness and elastin. RESULTS: Angiotensin II (Ang II)-infused hypertensive mice and spontaneously hypertensive rats (SHR) showed increased vascular LOX expression and stiffness and abnormal elastin structure...
December 23, 2016: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28009695/elastin-is-differentially-regulated-by-pressure-therapy-in-a-porcine-model-of-hypertrophic-scar
#16
Bonnie C Carney, Zekun Liu, Abdulnaser Alkhalil, Taryn E Travis, Jessica Ramella-Roman, Lauren T Moffatt, Jeffrey W Shupp
Beneficial effects of pressure therapy for hypertrophic scars have been reported, but the mechanisms of action are not fully understood. This study evaluated elastin and its contribution to scar pliability. The relationship between changes in Vancouver Scar Scale (VSS) scores of pressure-treated scars and differential regulation of elastin was assessed. Hypertrophic scars were created and assessed weekly using VSS and biopsy procurement. Pressure treatment began on day 70 postinjury. Treated scars were compared with untreated shams...
January 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/28009413/role-of-dextran-in-maintaining-adhesive-and-stiffness-properties-of-prestripped-dmek-lenticules
#17
Mohit Parekh, Alessandro Ruzza, Rosa Di Mundo, Stefano Ferrari, Giuseppina Recchia, Hossein Elbadawy, Giuseppe Carbone, Diego Ponzin
PURPOSE: To investigate the adhesive and stiffness properties of prestripped Descemet membrane endothelial keratoplasty (DMEK) lenticules in different preservation conditions (with and without dextran). METHODS: The study included 3 conditions: (C1) tissues collected from tissue culture media (TCM), stripped and preserved in TCM; (C2) tissues collected from transport media (TM) (TCM supplemented with 6% dextran T-500), stripped and preserved in TM; and (C3) tissues collected from TCM, stripped and preserved in TM...
November 25, 2016: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28008459/biologic-behavior-of-hydroxyapatite-used-in-facial-augmentation
#18
Richard J Huggins, Bryan C Mendelson
INTRODUCTION: The recent finding that shrinkage of key areas of the facial skeleton contributes to the aging appearance of the face has prompted a search for the most appropriate bone-like implant material. Evidence that hydroxyapatite, in granular form, maintains volume in the long term supports its use in the correction of aging, in addition to its use in the correction of inherently deficient areas of the facial skeleton. The biologic response of hydroxyapatite needs to be fully understood for its use to be confidently recommended...
December 23, 2016: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/27997981/single-nucleotide-polymorphisms-and-domain-splice-variants-modulate-assembly-and-elastomeric-properties-of-human-elastin-implications-for-tissue-specificity-and-durability-of-elastic-tissue
#19
Ming Miao, Sean E Reichheld, Lisa D Muiznieks, Eva E Sitarz, Simon Sharpe, Fred W Keeley
Polymeric elastin provides the physiologically essential properties of extensibility and elastic recoil to large arteries, heart valves, lungs, skin and other tissues. Although the detailed relationship between sequence, structure and mechanical properties of elastin remains a matter of investigation, data from both the full-length monomer, tropoelastin, and smaller elastin-like polypeptides have demonstrated that variations in protein sequence can affect both polymeric assembly and tensile mechanical properties...
December 20, 2016: Biopolymers
https://www.readbyqxmd.com/read/27995569/fourier-transform-infrared-spectroscopic-imaging-derived-collagen-content-and-maturity-correlates-with-stress-in-the-aortic-wall-of-abdominal-aortic-aneurysm-patients
#20
Rabee Cheheltani, Joseph E Pichamuthu, Jayashree Rao, Justin S Weinbaum, Mohammad F Kiani, David A Vorp, Nancy Pleshko
Abdominal aortic aneurysm (AAA) is a degenerative disease of the aorta characterized by severe disruption of the structural integrity of the aortic wall and its major molecular constituents. From the early stages of disease, elastin in the aorta becomes highly degraded and is replaced by collagen. Questions persist as to the contribution of collagen content, quality and maturity to the potential for rupture. Here, using our recently developed Fourier transform infrared imaging spectroscopy (FT-IRIS) method, we quantified collagen content and maturity in the wall of AAA tissues in pairs of specimens with different wall stresses...
December 19, 2016: Cardiovascular Engineering and Technology
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