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https://www.readbyqxmd.com/read/28637173/crystallographic-analyses-illustrate-significant-plasticity-and-efficient-recoding-of-meganuclease-target-specificity
#1
Rachel Werther, Jazmine P Hallinan, Abigail R Lambert, Kyle Havens, Mark Pogson, Jordan Jarjour, Roberto Galizi, Nikolai Windbichler, Andrea Crisanti, Tony Nolan, Barry L Stoddard
The retargeting of protein-DNA specificity, outside of extremely modular DNA binding proteins such as TAL effectors, has generally proved to be quite challenging. Here, we describe structural analyses of five different extensively retargeted variants of a single homing endonuclease, that have been shown to function efficiently in ex vivo and in vivo applications. The redesigned proteins harbor mutations at up to 53 residues (18%) of their amino acid sequence, primarily distributed across the DNA binding surface, making them among the most significantly reengineered ligand-binding proteins to date...
June 20, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28636617/backup-development-and-evaluation-of-a-smart-phone-application-for-coping-with-suicidal-crises
#2
Kirsten Pauwels, Saskia Aerts, Ekke Muijzers, Eva De Jaegere, Kees van Heeringen, Gwendolyn Portzky
BACKGROUND: Suicide is a major public health issue and has large impact on the lives of many people. Innovative technologies such as smartphones could create new possibilities for suicide prevention, such as helping to overcome the barriers and stigma on help seeking in case of suicidal ideation. Due to their omnipresence, smartphone apps can offer suicide prevention tools very fast, they are easily-accessible, low-threshold and can help overcome some of the help-seeking barriers suicidal people experience...
2017: PloS One
https://www.readbyqxmd.com/read/28636614/smartphone-dependence-classification-using-tensor-factorization
#3
Jingyun Choi, Mi Jung Rho, Yejin Kim, In Hye Yook, Hwanjo Yu, Dai-Jin Kim, In Young Choi
Excessive smartphone use causes personal and social problems. To address this issue, we sought to derive usage patterns that were directly correlated with smartphone dependence based on usage data. This study attempted to classify smartphone dependence using a data-driven prediction algorithm. We developed a mobile application to collect smartphone usage data. A total of 41,683 logs of 48 smartphone users were collected from March 8, 2015, to January 8, 2016. The participants were classified into the control group (SUC) or the addiction group (SUD) using the Korean Smartphone Addiction Proneness Scale for Adults (S-Scale) and a face-to-face offline interview by a psychiatrist and a clinical psychologist (SUC = 23 and SUD = 25)...
2017: PloS One
https://www.readbyqxmd.com/read/28636581/the-psylog-mobile-application-development-of-a-tool-for-the-assessment-and-monitoring-of-side-effects-of-psychotropic-medication
#4
Martina Rojnic Kuzman, Olivier Andlauer, Kai Burmeister, Boris Dvoracek, Rebekka Lencer, Katja Koelkebeck, Alexander Nawka, Florian Riese
Mobile health interventions are regarded as affordable and accessible tools that can enhance standard psychiatric care. As part of the mHealth Psycho-Educational Intervention Versus Antipsychotic-Induced Side Effects (mPIVAS) project (www.psylog.eu), we developed the mobile application "PsyLOG" based on mobile "smartphone" technology to monitor antipsychotic-induced side effects. The aim of this paper is to describe the rationale and development of the PsyLOG and its clinical use. The PsyLOG application runs on smartphones with Android operating system...
June 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28636347/the-structure-and-dynamics-of-alginate-gels-crosslinked-by-polyvalent-ions-probed-via-solid-state-nmr-spectroscopy
#5
Jiří Brus, Martina Urbanová, Jiri Czernek, Miroslava Pavelkova, Katerina Kubova, Jakub Vyslouzil, Sabina Abbrent, Rafal Konefal, Jiri Horsky, David Vetchy, Jan Vysloužil, Pavel Kulich
Alginate gels are an outstanding biomaterial widely applicable in tissue engineering, medicine, and pharmacy for cell transplantation, wound healing and efficient bioactive agent delivery, respectively. This contribution provides new and comprehensive insight into the atomic-resolution structure and dynamics of polyvalent ion-crosslinked alginate gels in microbead formulations. By applying various advanced solid-state NMR (ssNMR) spectroscopy techniques, we verified the homogenous distribution of the crosslinking ions in the alginate gels and the high degree of ion exchange...
June 21, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28636060/developing-mobile-clinical-decision-support-for-nursing-home-staff-assessment-of-urinary-tract-infection-using-goal-directed-design
#6
Wallace Jones, Cynthia Drake, David Mack, Blaine Reeder, Barbara Trautner, Heidi Wald
BACKGROUND: Unique characteristics of nursing homes (NHs) contribute to high rates of inappropriate antibiotic use for asymptomatic bacteriuria (ASB), a benign condition. A mobile clinical decision support system (CDSS) may support NH staff in differentiating urinary tract infections (UTI) from ASB and reducing antibiotic days. OBJECTIVES: We used Goal-Directed Design to: 1) Characterize information needs for UTI identification and management in NHs; 2) Develop UTI Decide, a mobile CDSS prototype informed by personas and scenarios of use constructed from Aim 1 findings; 3) Evaluate the UTI Decide prototype with NH staff...
June 20, 2017: Applied Clinical Informatics
https://www.readbyqxmd.com/read/28633528/the-binding-space-concept-a-new-approach-to-enhance-the-reliability-of-docking-scores-and-its-application-to-predicting-butyrylcholinesterase-bche-hydrolytic-activity
#7
Giulio Vistoli, Angelica Mazzolari, Bernard Testa, Alessandro Pedretti
Docking simulations are very popular approaches able to assess the capacity of a given ligand to interact with a target. Docking simulations are usually focused on a single best complex even though many studies showed that ligands retain a significant mobility within a binding pocket by assuming different binding modes all of which may contribute to the monitored ligand affinity. The present study describes an innovative concept, the binding space, which allows an exploration of the ligand mobility within the binding pocket by simultaneously considering several ligand poses as generated by docking simulations...
June 20, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28632552/comparative-study-of-c-arms-for-intraoperative-3-dimensional-imaging-and-navigation-in-minimally-invasive-spine-surgery-part-ii-radiation-exposure
#8
Jan-Helge Klingler, Ronen Sircar, Christian Scheiwe, Evangelos Kogias, Marie T Krüger, Christoph Scholz, Ulrich Hubbe
STUDY DESIGN: A radiation exposure study in vitro. OBJECTIVE: This study aimed to compare the radiation exposure of 2 different 3-dimensional (3D) C-arm devices on an anthropomorphic phantom. SUMMARY OF BACKGROUND DATA: Minimally invasive pedicle screw placement requires intraoperative imaging techniques for visualization of the unexposed spine. Mobile 3D C-arms compose a 3D image data set out of multiple successive fluoroscopic images. METHODS: We compared the 3D C-arm devices Siremobil Iso-C 3D (Siemens Sector Healthcare, Erlangen, Germany) and Vision FD Vario 3D (Ziehm Imaging, Nuremberg, Germany) regarding their radiation exposure...
July 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28632551/comparative-study-of-c-arms-for-intraoperative-3-dimensional-imaging-and-navigation-in-minimally-invasive-spine-surgery-part-i-applicability-and-image-quality
#9
Jan-Helge Klingler, Ronen Sircar, Christian Scheiwe, Evangelos Kogias, Florian Volz, Marie T Krüger, Ulrich Hubbe
STUDY DESIGN: This was a retrospective analysis. OBJECTIVE: This study compares 2 different 3-dimensional (3D) C-arm devices for intraoperative imaging and navigation with regard to clinical applicability and image quality. SUMMARY OF BACKGROUND DATA: Minimally invasive spine surgery requires intraoperative imaging techniques to adequately visualize the unexposed spine. For this purpose, mobile 3D C-arms became available along with the evolution of intraoperative navigation techniques...
July 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28632188/smartphone-based-food-diagnostic-technologies-a-review
#10
REVIEW
Giovanni Rateni, Paolo Dario, Filippo Cavallo
A new generation of mobile sensing approaches offers significant advantages over traditional platforms in terms of test speed, control, low cost, ease-of-operation, and data management, and requires minimal equipment and user involvement. The marriage of novel sensing technologies with cellphones enables the development of powerful lab-on-smartphone platforms for many important applications including medical diagnosis, environmental monitoring, and food safety analysis. This paper reviews the recent advancements and developments in the field of smartphone-based food diagnostic technologies, with an emphasis on custom modules to enhance smartphone sensing capabilities...
June 20, 2017: Sensors
https://www.readbyqxmd.com/read/28631466/enhancing-the-performance-of-polymer-solar-cells-by-using-donor-polymers-carrying-discretely-distributed-side-chains
#11
Xue Gong, Guangwu Li, Yang Wu, Jicheng Zhang, Shiyu Feng, Yahui Liu, Cuihong Li, Wei Ma, Zhishan Bo
Three-component conjugated polymers P1-1 and P1-2 were prepared by one-pot Stille cross-coupling reaction and applied for polymer solar cell (PSCs). The two-component polymer P1-0 only comprises 5-flouro-6-alkyloxybenzothiadiazole (AFBT) acceptor unit and thiophene donor unit; while the three-component polymers P1-1 and P1-2 contain 10% and 20% 5,6-difluorobenzothiadiazole (DFBT), respectively, as the third component. The incorporation of the third component, 5,6-difluorobenzothiadiazole, makes the side chains discretely distributed in the polymer backbones, which can enhance the π-π stacking of polymers in film, markedly increase the hole mobility of active layers, and improve the power conversion efficiency (PCE) of devices...
June 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28630034/fall-prevention-self-assessments-via-mobile-3d-visualization-technologies-community-dwelling-older-adults-perceptions-of-opportunities-and-challenges
#12
Julian Hamm, Arthur Money, Anita Atwal
BACKGROUND: In the field of occupational therapy, the assistive equipment provision process (AEPP) is a prominent preventive strategy used to promote independent living and to identify and alleviate fall risk factors via the provision of assistive equipment within the home environment. Current practice involves the use of paper-based forms that include 2D measurement guidance diagrams that aim to communicate the precise points and dimensions that must be measured in order to make AEPP assessments...
June 19, 2017: JMIR Human Factors
https://www.readbyqxmd.com/read/28629374/multi-purpose-ecg-telemetry-system
#13
Mohamed Marouf, Goran Vukomanovic, Lazar Saranovac, Miroslav Bozic
BACKGROUND: The Electrocardiogram ECG is one of the most important non-invasive tools for cardiac diseases diagnosis. Taking advantage of the developed telecommunication infrastructure, several approaches that address the development of telemetry cardiac devices were introduced recently. Telemetry ECG devices allow easy and fast ECG monitoring of patients with suspected cardiac issues. Choosing the right device with the desired working mode, signal quality, and the device cost are still the main obstacles to massive usage of these devices...
June 19, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28629156/spatial-indexing-for-data-searching-in-mobile-sensing-environments
#14
Yuchao Zhou, Suparna De, Wei Wang, Klaus Moessner, Marimuthu S Palaniswami
Data searching and retrieval is one of the fundamental functionalities in many Web of Things applications, which need to collect, process and analyze huge amounts of sensor stream data. The problem in fact has been well studied for data generated by sensors that are installed at fixed locations; however, challenges emerge along with the popularity of opportunistic sensing applications in which mobile sensors keep reporting observation and measurement data at variable intervals and changing geographical locations...
June 18, 2017: Sensors
https://www.readbyqxmd.com/read/28628838/validated-uplc-ms-ms-method-for-simultaneous-quantification-of-eight-saikosaponins-in-rat-plasma-application-to-a-comparative-pharmacokinetic-study-in-depression-rats-after-oral-administration-of-extracts-of-raw-and-vinegar-baked-bupleuri-radix
#15
Tianli Lei, Dandan Zhang, Kun Guo, Mingxiao Li, Chongning Lv, Jing Wang, Lingyun Jia, Jincai Lu
A sensitive and efficient UPLC-MS/MS method was developed and validated for simultaneous quantification of eight saikosaponins (SSa, SSb1, SSb2, SSb3, SSb4, SSc, SSd and SSf) in rat plasma. Furthermore, comparative pharmacokinetic profiles of these sakosaponins were investigated, following oral administration of extracts of raw and vinegar-baked Bupleuri Radix to depression rats. Biosamples were processed with liquid-liquid extraction technique using ethyl acetate. Chromatographic separation was accomplished on Waters BEH C18 UPLC column...
June 16, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28628837/the-influence-of-essential-oils-from-xiang-fu-si-wu-decoction-on-its-non-volatile-components-and-its-application-for-pharmacokinetics-in-normal-rats
#16
Ying Pan, Dawei Qian, Pei Liu, Yang Zhang, Zhenhua Zhu, Li Zhang, Jin-Ao Duan
Xiang-Fu-Si-Wu Decoction (XFSWD) has been used to treat gynecology diseases in clinical practice for hundreds of years in China, especially for primary dysmenorrheal of QiZhi Type. In previous researches, both essential oils (XEO) and non-volatile components (NXEO) extracted from XFSWD showed significant pharmacological activities, but the influence of XEO on NXEO was unclear. The purpose of this paper was to develop a validated analytical method for simultaneous determination of ten components including Vanillic acid, Ferulic acid, Caffeic acid, Gallic acid, Paeoniflorin, Albiflorin, Tetrahydropalmatine, Protopine, Berberine and Tetrahydrocolumbamine, and to compare the pharmacokinetic parameters of these components to illustrate the influences of XEO on NXEO in normal rats...
June 4, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28628300/application-of-struvite-alters-the-antibiotic-resistome-in-soil-rhizosphere-and-phyllosphere
#17
Qing-Lin Chen, Xin-Li An, Yong-Guan Zhu, Jian-Qiang Su, Michael R Gillings, Zhi-Long Ye, Li Cui
Struvite recovered from wastewater is a renewable source of phosphorus and nitrogen and can be used as fertilizer for plant growth. However, antibiotics and resistome can be enriched in the struvite derived from wastewater. Robust understanding of the potential risks after struvite application to soils has remained elusive. Here, we profiled antibiotic resistance genes (ARGs) and mobile genetic elements (MGEs) in struvite, soil, rhizosphere and phyllosphere of Brassica using high-throughput quantitative PCR...
June 19, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28627894/surface-functionalization-of-black-phosphorus-via-potassium-towards-high-performance-complementary-devices
#18
Cheng Han, Zehua Hu, Lidia C Gomes, Yang Bao, Alexandra Carvalho, Sherman Jun Rong Tan, Bo Lei, Du Xiang, Jing Wu, Dianyu Qi, Li Wang, Fengwei Huo, Wei Huang, Kian Ping Loh, Wei Chen
Two-dimensional black phosphorus configured field-effect transistor devices generally show a hole-dominated ambipolar transport characteristic, thereby limiting its applications in complementary electronics. Herein, we demonstrate an effective surface functionalization scheme on few-layer black phosphorus, through in situ surface modification with potassium, with a view towards high performance complementary device applications. Potassium induces a giant electron doping effect on black phosphorus along with a clear bandgap reduction, which is further corroborated by in situ photoelectron spectroscopy characterizations...
June 19, 2017: Nano Letters
https://www.readbyqxmd.com/read/28627755/labeling-dna-replication-foci-to-visualize-chromosome-territories-in-vivo
#19
Apolinar Maya-Mendoza, Dean A Jackson
While a detailed understanding of chromatin dynamics is needed to explain how higher-order chromatin organization influences nuclear function, the molecular principles that regulate chromatin mobility in mammalian nuclei remain largely unknown. Here we describe experimental tools to follow chromatin dynamics by labeling DNA during S phase. Using these methods, we have found that foci labeled during early and mid/late S phase have significantly different dynamic behavior. Spatially constrained heterochromatic foci restrict long-range transformations of the chromosome territory (CT) structure while providing a structural framework on which highly mobile euchromatic foci undergo positional oscillations that drive local changes in the chromosome shape...
June 19, 2017: Current Protocols in Cell Biology
https://www.readbyqxmd.com/read/28627165/room-temperature-processed-nb2o5-as-the-electron-transporting-layer-for-efficient-planar-perovskite-solar-cells
#20
Xufeng Ling, Jianyu Yuan, Dongyang Liu, Yongjie Wang, Yannan Zhang, Si Chen, Haihua Wu, Feng Jin, Fu-Peng Wu, Guozheng Shi, Xun Tang, Jiawei Zheng, Shengzhong Frank Liu, Zhike Liu, Wanli Ma
In this work , we demonstrate high-efficiency planar perovskite solar cells (PSCs) using room-temperature sputtered niobium oxide (Nb2O5) as the electron transporting layer (ETL). Widely spread ETL like TiO2 often requires high-temperature (> 450 ºC) sintering, which is not desired for the fabrication of flexible devices. The as sputtered amorphous Nb2O5 ETL (labeled as a-Nb2O5) without any heat treatment can lead to a best power conversion efficiency (PCE) of 17.1% for planar PSCs. Interestingly, the crystalline Nb2O5 (labeled as c-Nb2O5) with high-temperature (500 ºC) annealing results in very similar PCE of 17...
June 19, 2017: ACS Applied Materials & Interfaces
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