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https://www.readbyqxmd.com/read/28823022/long-term-bisphosphonate-therapy-in-osteogenesis-imperfecta
#1
REVIEW
A Biggin, C F Munns
PURPOSE OF REVIEW: Osteogenesis imperfecta (OI) is a genetic bone disorder resulting in bone fragility. It has a heterogeneous phenotype which typically includes reduced bone mass, multiple fractures, deformity, and chronic disability. Bisphosphonate treatment remains the first-line medical management, but there is still debate on aspects of its effectiveness. This review summarizes current knowledge about long-term bisphosphonate use in OI with recommendations on clinical application...
August 19, 2017: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/28822158/-fast-identification-of-constituents-of-lagotis-brevituba-by-using-uplc-q-tof-ms-ms-method
#2
Jing Xie, Li Zhang, Jin-Xiang Zeng, Min Li, Juan Wang, Xiong-Xiong Xie, Guo-Yue Zhong, Guang-Ming Luo, Jin-Bin Yuan, Jian Liang
The chemical constituents of Lagotis brevituba were rapidly determined and analyzed by using ultra performance liquid chromatography tandem quadrupole time of flight mass spectrometry (UPLC-Q-TOF-MS/MS) method, providing material basis for the clinical application of L. brevituba. The separation was performed on UPLC YMC-Triart C₁₈ (2.1 mm×100 mm, 1.9 μm) column, with acetonitrile-water containing 0.2% formic acid as mobile phase for gradient elution. The flow rate was 0.4 mL•min-1 gradient elution and column temperature was 40 ℃, the injection volume was 2 μL...
June 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28821773/a-patterned-single-layer-graphene-resistance-temperature-sensor
#3
Benyamin Davaji, Hak Dong Cho, Mohamadali Malakoutian, Jong-Kwon Lee, Gennady Panin, Tae Won Kang, Chung Hoon Lee
Micro-fabricated single-layer graphenes (SLGs) on a silicon dioxide (SiO2)/Si substrate, a silicon nitride (SiN) membrane, and a suspended architecture are presented for their use as temperature sensors. These graphene temperature sensors act as resistance temperature detectors, showing a quadratic dependence of resistance on the temperature in a range between 283 K and 303 K. The observed resistance change of the graphene temperature sensors are explained by the temperature dependent electron mobility relationship (~T(-4)) and electron-phonon scattering...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821474/validation-relaxation-a-quality-assurance-strategy-for-electronic-data-collection
#4
Avi Kenny, Nicholas Gordon, Thomas Griffiths, John D Kraemer, Mark J Siedner
BACKGROUND: The use of mobile devices for data collection in developing world settings is becoming increasingly common and may offer advantages in data collection quality and efficiency relative to paper-based methods. However, mobile data collection systems can hamper many standard quality assurance techniques due to the lack of a hardcopy backup of data. Consequently, mobile health data collection platforms have the potential to generate datasets that appear valid, but are susceptible to unidentified database design flaws, areas of miscomprehension by enumerators, and data recording errors...
August 18, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28820651/starting-and-stopping-kinetics-of-a-rear-mounted-power-assist-for-manual-wheelchairs
#5
Stephanie Wong, Ben Mortenson, Bonita Sawatzky
A rear mounted, powered, drive wheel has been developed to assist with mobility for manual wheelchairs in indoor and outdoor modes. To start the wheel, users must initiate handrim propulsion with sufficient force to trigger the motor. To stop the indoor mode, users must apply a braking force through the handrims exceeding the device's deceleration threshold. The objectives of this study were to compare 1) the minimum force required to start a wheelchair with and without the wheel, and 2) the distances and forces needed to stop a wheelchair at different treadmill speeds (3...
August 18, 2017: Assistive Technology: the Official Journal of RESNA
https://www.readbyqxmd.com/read/28820526/silica-nanoparticle-monolayers-on-a-macroion-modified-surface-formation-mechanism-and-stability
#6
M Morga, Z Adamczyk, D Kosior
Even though silica nanoparticles and their monolayers find a broad field of applications, only a few studies providing a quantitative description of silica nanoparticle deposition at solid/liquid interfaces have been reported in the literature. Given the deficit of reliable experimental data, the goal of this work is to acquire thorough physicochemical characteristics of amorphous silica nanoparticle deposition. Silica nanoparticle monolayers of controlled coverage were formed on macroion (PAH)-modified mica...
August 18, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28820461/thermal-response-analysis-of-phospholipid-bilayers-using-ellipsometric-techniques
#7
Carmen M González-Henríquez, Vanessa A Villegas-Opazo, Dallits H Sagredo-Oyarce, Mauricio A Sarabia-Vallejos, Claudio A Terraza
Biomimetic planar artificial membranes have been widely studied due to their multiple applications in several research fields. Their humectation and thermal response are crucial for reaching stability; these characteristics are related to the molecular organization inside the bilayer, which is affected by the aliphatic chain length, saturations, and molecule polarity, among others. Bilayer stability becomes a fundamental factor when technological devices are developed-like biosensors-based on those systems...
August 18, 2017: Biosensors
https://www.readbyqxmd.com/read/28820451/dynamic-fuzzy-logic-based-path-planning-for-mobility-assisted-localization-in-wireless-sensor-networks
#8
Abdullah Alomari, William Phillips, Nauman Aslam, Frank Comeau
Mobile anchor path planning techniques have provided as an alternative option for node localization in wireless sensor networks (WSNs). In such context, path planning is a movement pattern where a mobile anchor node's movement is designed in order to achieve a maximum localization ratio possible with a minimum error rate. Typically, the mobility path planning is designed in advance, which is applicable when the mobile anchor has sufficient sources of energy and time. However, when the mobility movement is restricted or limited, a dynamic path planning design is needed...
August 18, 2017: Sensors
https://www.readbyqxmd.com/read/28820303/rapid-ventricular-pacing-for-clip-reconstruction-of-complex-unruptured-intracranial-aneurysms-results-of-an-interdisciplinary-prospective-trial
#9
Juergen Konczalla, Johannes Platz, Stephan Fichtlscherer, Haitham Mutlak, Ulrich Strouhal, Volker Seifert
OBJECTIVE To date, treatment of complex unruptured intracranial aneurysms (UIAs) remains challenging. Therefore, advanced techniques are required to achieve an optimal result in treating these patients safely. In this study, the safety and efficacy of rapid ventricular pacing (RVP) to facilitate microsurgical clip reconstruction was investigated prospectively in a joined neurosurgery, anesthesiology, and cardiology study. METHODS Patients with complex UIAs were prospectively enrolled. Both the safety and efficacy of RVP were evaluated by recording cardiovascular events and outcomes of patients as well as the amount of aneurysm occlusion after the surgical clip reconstruction procedure...
August 18, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28820262/single-layer-tl2o-a-metal-shrouded-2d-semiconductor-with-high-electronic-mobility
#10
Yandong Ma, Agnieszka Kuc, Thomas Heine
First metal-shrouded two-dimensional semicon-ductor, single-layer Tl2O, is discussed from first-principles. It is thermally and dynamically stable, has a low cleavage energy call-ing for exfoliation from layered Tl2O bulk, and a very small inter-face mismatch compared to (001) Tl metal. Single-layer Tl2O ex-hibits a direct band gap of 1.56 eV and a very high charge carrier mobility of 4.3×103 cm2 V-1 s-1. The metal-shrouded 2D semicon-ductor promises interesting applications in 2D electronics. An in-triguing layer-thickness dependent direct-to-indirect bandgap tran-sition is observed, and contrary to early literature, the bulk is also a semiconductor...
August 18, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28820196/on-the-mobility-of-carriers-at-semi-coherent-oxide-heterointerfaces
#11
Pratik P Dholabhai, Enrique Martínez, Nicholas T Brown, Blas Pedro Uberuaga
In the quest to develop new materials with enhanced ionic conductivity for battery and fuel cell applications, nano-structured oxides have attracted attention. Experimental reports indicate that oxide heterointerfaces can lead to enhanced ionic conductivity, but these same reports cannot elucidate the origin of this enhancement, often vaguely referring to pipe diffusion at misfit dislocations as a potential explanation. However, this highlights the need to understand the role of misfit dislocation structure at semi-coherent oxide heterointerfaces in modifying carrier mobilities...
August 18, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28819973/mobile-platform-for-multiplexed-detection-and-differentiation-of-disease-specific-nucleic-acid-sequences-using-microfluidic-loop-mediated-isothermal-amplification-and-smartphone-detection
#12
Weili Chen, Hojeong Yu, Fu Sun, Akid Ornob, Ryan Brisbin, Anurup Ganguli, Vinay Kumar Vemuri, Piotr Strzebonski, Guangzhe Cui, Karen J Allen, Smit A Desai, Weiran Lin, David M Nash, David Hirschberg, Ian Brooks, Rashid Bashir, Brian T Cunningham
New tools are needed to enable rapid detection, identification, and reporting of infectious viral and microbial pathogens in a wide variety of point-of-care applications that impact human and animal health. We report the design, construction, and characterization of a platform for multiplexed analysis of disease-specific DNA sequences that utilizes a smartphone camera as the sensor in conjunction with a handheld "cradle" that interfaces the phone with a silicon-based microfluidic chip embedded within a credit card-sized cartridge...
August 18, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28819928/development-of-a-rating-tool-for-mobile-cancer-apps-information-analysis-and-formal-and-content-related-evaluation-of-selected-cancer-apps
#13
Cathleen Böhme, Marc Baron von Osthoff, Katrin Frey, Jutta Hübner
Mobile apps are offered in large numbers and have different qualities. The aim of this article was to develop a rating tool based on formal and content-related criteria for the assessment of cancer apps and to test its applicability on apps. After a thorough analysis of the literature, we developed a specific rating tool for cancer apps based on the MARS (mobile app rating system) and a rating tool for cancer websites. This instrument was applied to apps freely available in stores and focusing on some cancer topic...
August 17, 2017: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/28819683/an-iphone-application-using-a-novel-stool-color-detection-algorithm-for-biliary-atresia-screening
#14
Eri Hoshino, Kuniyoshi Hayashi, Mitsuyoshi Suzuki, Masayuki Obatake, Kevin Y Urayama, Satoshi Nakano, Yasuyuki Taura, Masaki Nio, Osamu Takahashi
BACKGROUND: The stool color card has been the primary tool for identifying acholic stools in infants with biliary atresia (BA), in several countries. However, BA stools are not always acholic, as obliteration of the bile duct occurs gradually. This study aims to introduce Baby Poop (Baby unchi in Japanese), a free iPhone application, employing a detection algorithm to capture subtle differences in colors, even with non-acholic BA stools. METHODS: The application is designed for use by caregivers of infants aged approximately 2 weeks-1 month...
August 17, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/28819287/characterization-of-polycrystalline-lead-oxide-for-application-in-direct-conversion-x-ray-detectors
#15
O Semeniuk, O Grynko, G Decrescenzo, G Juska, K Wang, A Reznik
While polycrystalline lead oxide (poly-PbO) is known to be one of the most promising photoconductors for utilization in X-ray detectors, its major performance parameters such as charge yield and mobility-lifetime product (μτ) are still not well established and require further investigation. Combining the conventional X-ray induced photocurrent and pulse height spectroscopy techniques we examine the X-ray photogeneration and recombination processes in poly-PbO. The measurements indicate that the amount of energy required to release a single electron hole pair W ± (inverse of charge yield) strongly depends on applied electric field and at 10 V/μm reaches ~20 eV/ehp...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28819184/black-phosphorus-ink-formulation-for-inkjet-printing-of-optoelectronics-and-photonics
#16
Guohua Hu, Tom Albrow-Owen, Xinxin Jin, Ayaz Ali, Yuwei Hu, Richard C T Howe, Khurram Shehzad, Zongyin Yang, Xuekun Zhu, Robert I Woodward, Tien-Chun Wu, Henri Jussila, Jiang-Bin Wu, Peng Peng, Ping-Heng Tan, Zhipei Sun, Edmund J R Kelleher, Meng Zhang, Yang Xu, Tawfique Hasan
Black phosphorus is a two-dimensional material of great interest, in part because of its high carrier mobility and thickness dependent direct bandgap. However, its instability under ambient conditions limits material deposition options for device fabrication. Here we show a black phosphorus ink that can be reliably inkjet printed, enabling scalable development of optoelectronic and photonic devices. Our binder-free ink suppresses coffee ring formation through induced recirculating Marangoni flow, and supports excellent consistency (< 2% variation) and spatial uniformity (< 3...
August 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/28818663/a-lightweight-inexpensive-robotic-system-for-insect-vision
#17
Chelsea Sabo, Robert Chisholm, Adam Petterson, Alex Cope
Designing hardware for miniaturized robotics which mimics the capabilities of flying insects is of interest, because they share similar constraints (i.e. small size, low weight, and low energy consumption). Research in this area aims to enable robots with similarly efficient flight and cognitive abilities. Visual processing is important to flying insects' impressive flight capabilities, but currently, embodiment of insect-like visual systems is limited by the hardware systems available. Suitable hardware is either prohibitively expensive, difficult to reproduce, cannot accurately simulate insect vision characteristics, and/or is too heavy for small robotic platforms...
August 14, 2017: Arthropod Structure & Development
https://www.readbyqxmd.com/read/28818337/the-mobile-technology-era-potential-benefits-in-pediatric-urology
#18
Sarah Mozafarpour, Reza Abbasioun, Abdol-Mohammad Kajbafzadeh
Mobile technology has been increasingly used in the world of medicine. We describe an application of mobile phones in the evaluation of urinary symptoms in infants, neonates, and toddlers. We believe this is a cheap, accessible and easy-to-use solution in pediatric urology for physicians and nurses around the world. In this video, we demonstrate some unique features of various anatomic and functional pediatric urology conditions, which are detectable in voiding clips taken by a cellphone camera.
August 3, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28818075/perspectives-of-basic-wheelchair-users-on-improving-their-access-to-wheelchair-services-in-kenya-and-philippines-a-qualitative-study
#19
Emma Williams, Elizabeth Hurwitz, Immaculate Obaga, Brenda Onguti, Adovich Rivera, Tyrone Reden L Sy, R Lee Kirby, Jamie Noon, Deepti Tanuku, Anthony Gichangi, Eva Bazant
BACKGROUND: The United Nations has called for countries to improve access to mobility devices when needed. The World Health Organization has published guidelines on the provision of manual wheelchairs in less-resourced settings. Yet little is known about the extent to which appropriate wheelchairs are available and provided according to international guidelines. This study's purpose was to describe wheelchair users' experiences receiving services and acquiring wheelchair skills in urban and peri-urban areas of Kenya and the Philippines...
August 17, 2017: BMC International Health and Human Rights
https://www.readbyqxmd.com/read/28817710/excessive-use-of-wechat-social-interaction-and-locus-of-control-among-college-students-in-china
#20
Juan Hou, Yamikani Ndasauka, Yingying Jiang, Zi Ye, Ying Wang, Lizhuang Yang, Xiaoming Li, Yongjun Zhang, Liangjun Pang, Yan Kong, Fei Xu, Xiaochu Zhang
In China, the number of college students using mobile phone based messaging and social networking applications like WeChat is increasing rapidly. However, there has been minimal research into the addictive nature of these applications and the psychological characteristics associate with their excessive use. There is also no published scale available for assessing excessive use of WeChat and similar applications. In the current study, we collected data from 1,245 college students in China (715 females) and developed the WeChat Excessive Use Scale (WEUS)...
2017: PloS One
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