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Ciarán Haberlin, Tom O'Dwyer, David Mockler, Jonathan Moran, Dearbhaile M O'Donnell, Julie Broderick
PURPOSE: Achieving adequate levels of physical activity (PA) and avoiding sedentary behaviour are particularly important in cancer survivors. eHealth, which includes, but is not limited to, the delivery of health information through Internet and mobile technologies, is an emerging concept in healthcare which may present opportunities to improve PA in cancer survivors. The aim of this systematic review was to explore the effects of eHealth in the promotion of PA among cancer survivors...
June 16, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Douglas T Hidlay, Ryan A McTaggart, Grayson Baird, Shadi Yaghi, Morgan Hemendinger, Eric L Tung, Eleanor L Dibiasio, Richard A Haas, Mahesh V Jayaraman
OBJECTIVES: Mechanical thrombectomy is the standard of care for stroke caused by an emergent large vessel occlusion in the anterior circulation, and the ability to rapidly review CTA is one hurdle in minimizing the time from diagnosis to intervention. We evaluated the diagnostic accuracy and confidence in review of stroke CTA for ELVO via a smartphone-based application as compared to PACS workstation. PATIENTS AND METHODS: Seventy-six head and neck CTA studies performed for stroke from one comprehensive and seven primary stroke centers were independently reviewed remotely on smartphone by two blinded interventional neuroradiologists in actual-use circumstances...
June 11, 2018: Clinical Neurology and Neurosurgery
Wenjie Zhang, Ying Ding, Li Sun, Qing Hong, Yumei Sun, Liangliang Han, Mengting Zi, Yuekang Xu
Dendritic cells (DCs) contain heterogeneous populations, with classical DCs developed at steady state and monocyte-derived DCs mobilized under inflammatory conditions, although their total numbers in vivo are scares. To obtain enough quantity for immunological study or clinical application, we have previously established that bone marrow-derived DCs in the presence of Flt-3L (FL-DCs) or GM-CSF (GM-DCs) in vitro are equivalent to the steady state DCs and inflammatory DCs in vivo respectively. What difference, however, exists between these two most commonly used culture systems in DC functions and survival, and how does it correlate to the division of works by their corresponding counterparts in vivo remain ill-defined...
June 7, 2018: Cellular Immunology
Conor Senecal, R Jay Widmer, Matthew P Johnson, Lilach O Lerman, Amir Lerman
BACKGROUND: Hypertension is a common and difficult-to-treat condition; digital health tools may serve as adjuncts to traditional pharmaceutical and lifestyle-based interventions. Using a retrospective observational study we sought to evaluate the effect of a desktop and mobile digital health intervention (DHI) as an adjunct to a workplace health program in those previously diagnosed with hypertension. METHODS: As part of a workplace health program, 3330 patients were identified as previously diagnosed with hypertension...
May 30, 2018: Journal of the American Society of Hypertension: JASH
Hong Zheng, Feng Qiu, Hui Zhao, Jie Chen, Lei Wang, Haiyan Zou
A specific, sensitive and rapid ultra high performance liquid chromatography-tandem mass spectrometric (UHPLC-MS/MS) method was developed and validated for simultaneous determination of six major bioactive constituents in Rhizoma Panacis Japonici (RPJ), including oleanolic acid-type chikusetsusaponin V, IV, hemsgiganoside B, damarane-type ginsenoside Rb1, Rg1 and Re in rat plasma, using estazolam as the internal standard (IS). Plasma samples were pretreated with methanol/acetonitrile (1:1, V/V) for protein precipitation...
June 7, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Jun Liu, Tao Wang, Chuandong Dou, Lixiang Wang
Organoboron chemistry is a new tool to tune the electronic structures and properties of conjugated polymers, which are important for applications in organic opto-electronic devices. To investigate the effects of substituents of boron atoms on conjugated polymers, we synthesized three conjugated polymers based on double B←N bridged bipyridine (BNBP) with various substituents on the boron atoms. By changing the substituents from four phenyl groups and two phenyl groups/two fluorine atoms to four fluorine atoms, the BNBP-based polymers show the blue-shifted absorption spectra, decreased LUMO/HOMO energy levels and enhanced electron affinities, as well as the increased electron mobilities...
June 15, 2018: Chemistry: a European Journal
Filip Moučka, Jiří Kolafa, Martin Lísal, William R Smith
We present a molecular-level simulation study of CaCl2 in water and crystalline hydrates formed by CaCl2 at ambient (298.15 K, 1 bar) conditions and at a high-temperature high-pressure state (365 K, 275 bars) typical of hydraulic fracturing conditions in natural-gas extraction, at which experimental properties are poorly characterized. We focus on simulations of chemical potentials in both solution and crystalline phases and on the salt solubility, the first time to our knowledge that such properties have been investigated by molecular simulation for divalent aqueous electrolytes...
June 14, 2018: Journal of Chemical Physics
Firas Chakroun, Vera Colombo, Dave Lie Sam Foek, Luigi Maria Gallo, Albert Feilzer, Mutlu Özcan
PURPOSE: The objective of this study was to evaluate the anterior tooth movement without and with bonded fixed orthodontic retainers under incremental loading conditions. MATERIALS AND METHODS: Six extracted mandibular anterior human teeth were embedded in acrylic resin in True Form I Arch type and 3D reconstruction of Digital Volume Tomography (DVT) images (0.4 mm3 voxels) were obtained. The anatomy of each tooth was segmented and digitally reconstructed using 3D visualization software for medical images (AMIRA, FEI SVG)...
June 6, 2018: Journal of the Mechanical Behavior of Biomedical Materials
Dan Kawamori
Glucagon secreted by pancreatic α-cells plays pivotal roles in the systemic energy homeostasis mainly by regulating systemic glucose mobilization together with another important metabolic hormone, insulin. Recent application of the incretin-based therapies to clinical diabetes refocused on the central roles of glucagon in the development of diabetic hyperglycemia. This revival of glucagon also enhanced the progress of basic research in α-cell biology, as targeting glucagon is now expected to be the next therapeutic approach in diabetes treatment...
June 15, 2018: Journal of Diabetes Investigation
Troy Morrison, Sara Jones, Ryan S Causby, Kerry Thoirs
INTRODUCTION: Diabetes mellitus (DM) is associated with hyperglycaemia and advanced glycosylation end-products. In the foot, the consequences of chronic or uncontrolled diabetes are micro and macrovascular disease, neuropathy, reduced joint mobility and structural and soft tissue changes that increase the risk of ulcer development and amputation. Diabetes foot assessment currently includes a comprehensive history, neurological and vascular assessments and examination focussed on dermatological and musculoskeletal abnormalities...
2018: PloS One
Roberto Maria-Hormigos, Beatriz Jurado Sánchez, Alberto Escarpa
Tubular micromotors composed of a hybrid single wall carbon nanotubes (SW)-Fe2O3 outer layer and powered by MnO2 catalyst are used for phenylenediamines isomers detection and discrimination. Catalytic decomposition of H2O2 as fuel results in the production of oxygen bubbles and hydroxyl radicals for phenylenediamines dimerization to produce colorful solutions in colorimetric assays. The combination of Fe2O3 nanoparticles along with the irregular SW backbone results in a rough catalytic layer for enhanced hydroxyl radical production rate and improved analytical sensitivity...
June 15, 2018: Analytical Chemistry
R Levandovsky, N Belikova, A Belikov, O Godovanets, G Nakashidze
The aim of the study was to develop the most optimal variant for placing the reinforcing element of a fiberglass splint with the mobility of the anterior teeth on the basis of a parallelometric study of the diagnostic models of the jaws depending on the type of occlusion and the degree of bone resorption. For the most optimal variant of the placement of the reinforcing element of the adhesive splint with orthognathic bite and deep incisal overlap, the front slope of the model was selected with the transfer of the reinforcing element of the adhesive splint onto the lingual surface...
May 2018: Georgian Medical News
Yingchang Jiang, Zeyi Wu, Le Jiang, Zhichang Pan, Peiyu Yang, Wenchao Tian, Linfeng Hu
The integration of high flexibility, high energy density and wide voltage window for solid-state supercapacitors remains a big challenge to date. Herein, ultrathin CoSeO3·H2O nanoribbons (thickness: ∼14 nm) with typical pseudocapacitive behavior were synthesized in a high yield by a solution-based refluxing process. Freestanding CoSeO3·H2O ribbon/hydroxylated multi-walled carbon nanotube (HWCNT) paper could be fabricated through a vacuum-assisted filtration strategy owing to its ultrathin nature, ribbon-like morphology and inherent flexibility...
June 15, 2018: Nanoscale
Ao Liu, Huihui Zhu, Huabin Sun, Yong Xu, Yong-Young Noh
The electronic functionalities of metal oxides comprise conductors, semiconductors, and insulators. Metal oxides have attracted great interest for construction of large-area electronics, particularly thin-film transistors (TFTs), for their high optical transparency, excellent chemical and thermal stability, and mechanical tolerance. High-permittivity (κ) oxide dielectrics are a key component for achieving low-voltage and high-performance TFTs. With the expanding integration of complementary metal oxide semiconductor transistors, the replacement of SiO2 with high-κ oxide dielectrics has become urgently required, because their provided thicker layers suppress quantum mechanical tunneling...
June 14, 2018: Advanced Materials
Margaret Smith, Miriam Segura-Totten, Kelly West
The impact of the Internet on education has been recognized for decades, and as technology advances, the ways in which students can access Internet content is ever increasing. Most students have some kind of portable smart device with which they access Internet content without the locational constraints of a desktop computer. This mobility has prompted abundant literature suggesting ways that Quick Response Codes (QR codes), a kind of two dimensional barcode, could be used to advance student learning. However, very few studies have tested the usefulness of QR codes in undergraduate science classes...
2018: Journal of Microbiology & Biology Education: JMBE
Deyang Ji, Tao Li, Ye Zou, Ming Chu, Ke Zhou, Jinyu Liu, Guofeng Tian, Zhaoyang Zhang, Xu Zhang, Liqiang Li, Dezhen Wu, Huanli Dong, Qian Miao, Harald Fuchs, Wenping Hu
The ever-increasing demand for flexible electronics calls for the development of low-voltage and high-mobility organic thin-film transistors (OTFTs) that can be integrated into emerging display and labeling technologies. Polymer dielectrics with comprehensive and balanced dielectric properties (i.e., a good balance between their insulating characteristics and compatibility with organic semiconductors) are considered particularly important for this end. Here, we introduce a simple but highly efficient strategy to realize this target by using a new type of copolymer as dielectrics...
June 14, 2018: Nature Communications
Bernhard Durner, Thomas Ehmann, Frank-Michael Matysik
The adaption of an parallel-path poly(tetrafluoroethylene)(PTFE) ICP-nebulizer to an evaporative light scattering detector (ELSD) was realized. This was done by substituting the originally installed concentric glass nebulizer of the ELSD. The performance of both nebulizers was compared regarding nebulizer temperature, evaporator temperature, flow rate of nebulizing gas and flow rate of mobile phase of different solvents using caffeine and poly(dimethylsiloxane) (PDMS) as analytes. Both nebulizers showed similar performances but for the parallel-path PTFE nebulizer the performance was considerably better at low LC flow rates and the nebulizer lifetime was substantially increased...
June 5, 2018: Journal of Chromatography. A
Hadir M Maher, Nourah Z Alzoman, Shereen M Shehata, Norah O Abanmy
Dasatinib (DAS) is a tyrosine kinase inhibitor (TKI) used in the treatment of chronic myeloid leukemia and in the management of ulcerative colitis (UC). Since some nutraceuticals (e.g. curcumin, olive oil, and cocoa extract) could alter the function of ABC transporters and /or CYP450 enzymes, DAS bioavailability could potentially be affected following their co-administration. This work aims at studying the possibility of PK interaction between DAS and the selected nutraceuticals in UC rats using UPLC- MS/MS...
2018: PloS One
Grigorios Koulouras, Andreas Panagopoulos, Maria A Rapsomaniki, Nickolaos N Giakoumakis, Stavros Taraviras, Zoi Lygerou
Understanding protein dynamics is crucial in order to elucidate protein function and interactions. Advances in modern microscopy facilitate the exploration of the mobility of fluorescently tagged proteins within living cells. Fluorescence recovery after photobleaching (FRAP) is an increasingly popular functional live-cell imaging technique which enables the study of the dynamic properties of proteins at a single-cell level. As an increasing number of labs generate FRAP datasets, there is a need for fast, interactive and user-friendly applications that analyze the resulting data...
June 13, 2018: Nucleic Acids Research
Q H Tan, Qianjin Wang, Yingkai Liu, Chunsheng Liu, Xiaobo Feng, Dapeng Yu
Graphene is one of the most promising spintronic materials due to its high carrier mobility. However, the absence of a band gap and ferromagnetic order in graphene seriously limit its applications in spintronics. How to utilize its high carrier mobility as well as mediate its electronic structure remains a challenge. Herein, we design a novel composite, which is composed of graphene and Mn-doped monolayer MoS2. The magnetic properties and electronic structures of graphene/Mn-doped monolayer MoS2 heterostructures were studied by using density functional theory (DFT) with the van der Waals (vdW) correlations (DFT-D)...
June 14, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
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