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https://www.readbyqxmd.com/read/28343376/ruthenium-106-brachytherapy-with-or-without-additional-local-therapy-showed-favorable-outcome-for-variable-sized-choroidal-melanomas-in-korean-patients
#1
Yeona Cho, Jee Suk Chang, Jin Sook Yoon, Sung Chul Lee, Yong Bae Kim, Joo Ho Kim, Ki Chang Keum
Purpose: To report clinical outcomes of ruthenium-106 (Ru-106) brachytherapy with or without additional local therapy for choroidal melanomas in Korean patients. Materials and Methods: A total of 88 patients diagnosed with choroidal melanomas were treated with Ru-106 brachytherapy between 2006 and 2012. Patients were divided into two groups according to their tumor height: a large group (≥6 mm, n=50) and a small group (<6 mm, n=38). Most patients in the large group received combined therapy with local excision and/or transpupillary thermotherapy...
March 24, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28343373/weighted-win-loss-approach-for-analyzing-prioritized-outcomes
#2
Xiaodong Luo, Junshan Qiu, Steven Bai, Hong Tian
To analyze prioritized outcomes, Buyse (2010) and Pocock et al. (2012) proposed the win loss approach. In this paper, we first study the relationship between the win loss approach and the traditional survival analysis on the time to the first event. We then propose the weighted win loss statistics to improve the efficiency of the unweighted methods. A closed-form variance estimator of the weighted win loss statistics is derived to facilitate hypothesis testing and study design. We also calculated the contribution index to better interpret the results of the weighted win loss approach...
March 26, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28343349/modernizing-quality-of-life-assessment-development-of-a-multidimensional-computerized-adaptive-questionnaire-for-patients-with-schizophrenia
#3
Pierre Michel, Karine Baumstarck, Christophe Lancon, Badih Ghattas, Anderson Loundou, Pascal Auquier, Laurent Boyer
OBJECTIVE: Quality of life (QoL) is still assessed using paper-based and fixed-length questionnaires, which is one reason why QoL measurements have not been routinely implemented in clinical practice. Providing new QoL measures that combine computer technology with modern measurement theory may enhance their clinical use. The aim of this study was to develop a QoL multidimensional computerized adaptive test (MCAT), the SQoL-MCAT, from the fixed-length SQoL questionnaire for patients with schizophrenia...
March 25, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28343341/public-availability-of-research-data-in-dentistry-journals-indexed-in-journal-citation-reports
#4
Antonio Vidal-Infer, Beatriz Tarazona, Adolfo Alonso-Arroyo, Rafael Aleixandre-Benavent
OBJECTIVES: Dentistry is a medical discipline with an increasing scientific production in the last years. Due to the importance of data sharing in science, this study aims at analyzing the availability of raw data in articles from scientific journals indexed in the Dentistry category of the 2014 edition of the Journal Citation Reports. MATERIAL AND METHODS: A review of the 88 websites of journals from the Dentistry category was conducted to determine the data-sharing editorial policies...
March 26, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28343331/economic-and-public-health-consequences-of-delayed-access-to-medical-care-for-migrants-living-with-hiv-in-france
#5
Marlène Guillon, Michel Celse, Pierre-Yves Geoffard
In 2013, migrants accounted for 46% of newly diagnosed cases of HIV (human immunodeficiency virus) infection in France. These populations meet with specific obstacles leading to late diagnosis and access to medical care. Delayed access to care (ATC) for HIV-infected migrants reduces their life expectancy and quality of life. Given the reduction of infectivity under antiretroviral (ARV) treatment, delayed ATC for HIV-infected migrants may also hinder the control of the HIV epidemic. The objective of this study is to measure the public health and economic consequences of delayed ATC for migrants living with HIV in France...
March 25, 2017: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
https://www.readbyqxmd.com/read/28343328/skeletal-development-of-the-hand-and-wrist-digital-bone-age-companion-a-suitable-alternative-to-the-greulich-and-pyle-atlas-for-bone-age-assessment
#6
Paul M Bunch, Talissa A Altes, Joan McIlhenny, James Patrie, Cree M Gaskin
PURPOSE: To assess reader performance and subjective workflow experience when reporting bone age studies with a digital bone age reference as compared to the Greulich and Pyle atlas (G&P). We hypothesized that pediatric radiologists would achieve equivalent results with each method while digital workflow would improve speed, experience, and reporting quality. MATERIALS AND METHODS: IRB approval was obtained for this HIPAA-compliant study. Two pediatric radiologists performed research interpretations of bone age studies randomized to either the digital (Digital Bone Age Companion, Oxford University Press) or G&P method, generating reports to mimic clinical workflow...
March 25, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28343325/mri-can-accurately-detect-meniscal-ramp-lesions-of-the-knee
#7
Justin W Arner, Elmar Herbst, Jeremy M Burnham, Ashish Soni, Jan-Hendrik Naendrup, Adam Popchak, Freddie H Fu, Volker Musahl
PURPOSE: Posterior horn meniscal tears are commonly found in conjunction with anterior cruciate ligament (ACL) injury. Some believe tears in the posterior meniscocapsular zone, coined ramp lesions, are important to knee stability. The purpose of this study was to determine whether pre-operative MRI evaluation was able to accurately and reproducibly identify ramp lesions. METHODS: Three blinded reviewers assessed MRIs twice for the presence of ramp lesions in patients undergoing ACL reconstruction...
March 25, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28343321/a-risk-score-based-on-admission-characteristics-to-predict-progressive-hemorrhagic-injury-from-traumatic-brain-injury-in-children
#8
Guo-Wen Hu, Hai-Li Lang, Hua Guo, Lei Wu, Pei Zhang, Wei Kuang, Xin-Gen Zhu
Traumatic brain injury (TBI) is one of the leading causes of death and disability in children, and progressive hemorrhagic injury (PHI) post TBI is associated with poor outcomes. Therefore, the objective of this study was to develop and validate a prognostic model that uses the information available at admission to determine the likelihood of PHI occurrence after TBI in children. The identified demographic data, cause of injury, clinical predictors on admission, computed tomography scan characteristics, and routine laboratory parameters were collected and used to develop a PHI prognostic model with logistic regression analysis, and the prediction model was validated in 68 children...
March 25, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28343316/translation-and-validation-of-iciq-fluts-for-tamil-speaking-women
#9
Chanil D Ekanayake, Arunasalam Pathmeswaran, A A Nilanga Nishad, Kanishka U Samaranayake, Prasantha S Wijesinghe
AIMS: Research in to lower urinary tract symptoms (LUTS) in women in South Asia is hampered by lack of validated tools. Our aim was to validate the International Consultation on Incontinence Modular Questionnaire on Female Lower Urinary Tract Symptoms (ICIQ-FLUTS) from English to Tamil. METHOD: After translation to Tamil, a validation study was carried out among women attending the gynecology clinic at District General Hospital-Mannar. RESULTS: Content validity assessed by the level of missing data was <2%...
March 25, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28343306/the-ins-and-outs-of-molecular-pathology-reporting
#10
REVIEW
Véronique Tack, Kelly Dufraing, Zandra C Deans, Han J van Krieken, Elisabeth M C Dequeker
The raid evolution in molecular pathology resulting in an increasing complexity requires careful reporting. The need for standardisation is clearer than ever. While synoptic reporting was first used for reporting hereditary genetic diseases, it is becoming more frequent in pathology, especially molecular pathology reports too. The narrative approach is no longer feasible with the growing amount of essential data present on the report, although narrative components are still necessary for interpretation in molecular pathology...
March 26, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28343304/geometry-calibration-between-x-ray-source-and-detector-for-tomosynthesis-with-a-portable-x-ray-system
#11
Kohei Sato, Takashi Ohnishi, Masashi Sekine, Hideaki Haneishi
PURPOSE: Tomosynthesis is attracting attention as a low-dose tomography technology compared with X-ray CT. However, conventional tomosynthesis imaging devices are large and stationary. Furthermore, there is a limitation in the working range of the X-ray source during image acquisition. We have previously proposed the use of a portable X-ray device for tomosynthesis that can be used for ward rounds and emergency medicine. The weight of this device can be reduced by using a flat panel detector (FPD), and flexibility is realized by the free placement of the X-ray source and FPD...
March 25, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28343303/can-real-time-rgbd-enhance-intraoperative-cone-beam-ct
#12
Javad Fotouhi, Bernhard Fuerst, Wolfgang Wein, Nassir Navab
PURPOSE: Cone-Beam Computed Tomography (CBCT) is an important 3D imaging technology for orthopedic, trauma, radiotherapy guidance, angiography, and dental applications. The major limitation of CBCT is the poor image quality due to scattered radiation, truncation, and patient movement. In this work, we propose to incorporate information from a co-registered Red-Green-Blue-Depth (RGBD) sensor attached near the detector plane of the C-arm to improve the reconstruction quality, as well as correcting for undesired rigid patient movement...
March 25, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28343302/force-assisted-ultrasound-imaging-system-through-dual-force-sensing-and-admittance-robot-control
#13
Ting-Yun Fang, Haichong K Zhang, Rodolfo Finocchi, Russell H Taylor, Emad M Boctor
PURPOSE: Ultrasound imaging has been a gold standard for clinical diagnoses due to its unique advantages compared to other imaging modalities including: low cost, noninvasiveness, and safeness to the human body. However, the ultrasound scanning process requires applying a large force over extended periods of time, often in uncomfortable postures in order to maintain the desired orientation. This physical requirement over sonographers' careers often leads to musculoskeletal pain and strain injuries...
March 25, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28343283/the-types-of-trust-involved-in-american-muslim-healthcare-decisions-an-exploratory-qualitative-study
#14
Aasim I Padela, Liese Pruitt, Saleha Mallick
Trust in physicians and the healthcare system underlies some disparities noted among minority populations, yet a descriptive typology of different types of trust informing healthcare decisions among minority populations is limited. Using data from 13 focus groups with 102 American Muslims, we identified the types and influence of trust in healthcare decision-making. Participants conveyed four types of trust implicating their health-seeking behaviors-(I) trust in allopathic medicine, (II) trust in God, (III) trust in personal relationships, and (IV) trust in self...
March 25, 2017: Journal of Religion and Health
https://www.readbyqxmd.com/read/28343265/effect-of-10-cerium-chloride-on-artificial-caries-lesions-of-human-enamel-evaluated-using-quantitative-light-induced-fluorescence-an-in-vitro-study
#15
R Jaisingh, R Shanbhog, B Nandlal, M Thippeswamy
AIM: To evaluate the effect of 10% cerium chloride intervention on pre-demineralised human enamel subjected to cycles of de- and remineralisation. METHODS: This was an in vitro, comparative type study of 60 human enamel samples that were randomly divided into control and test groups. The samples were then subjected to a cycle of demineralisation followed by intervention with respective treatment solutions (control group: placebo solution; test: 10% cerium chloride) for 30 s under constant agitation and then to a 2nd cycle of demineralisation followed by remineralisation using artificial saliva...
March 25, 2017: European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/28343264/modulating-the-ph-activity-profiles-of-phenylalanine-ammonia-lyase-from-anabaena-variabilis-by-modification-of-center-near-surface-residues
#16
Fan Zhang, Nan Huang, Li Zhou, Wenjing Cui, Zhongmei Liu, Longbao Zhu, Yi Liu, Zhemin Zhou
Phenylalanine ammonia lyase from Anabaena variabilis (Av-PAL) is a candidate for the treatment of phenylketonuria (PKU). However, Av-PAL shows its optimal pH at 8.5 and maintains only 70% of its highest activity when pH decreases to 7.3-7.4 (the condition of human plasma). The objective of the study was to shift its optimal pH by mutating surface amino acid residues which interact with the general base Tyr78. Based on the crystal structure and the online program GETAREA, we selected five sites: Asn69, Glu72, Glu75, Asn89, and Val90...
March 25, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28343239/improved-full-length-killer-cell-immunoglobulin-like-receptor-transcript-discovery-in-mauritian-cynomolgus-macaques
#17
Trent M Prall, Michael E Graham, Julie A Karl, Roger W Wiseman, Adam J Ericsen, Muthuswamy Raveendran, R Alan Harris, Donna M Muzny, Richard A Gibbs, Jeffrey Rogers, David H O'Connor
Killer cell immunoglobulin-like receptors (KIRs) modulate disease progression of pathogens including HIV, malaria, and hepatitis C. Cynomolgus and rhesus macaques are widely used as nonhuman primate models to study human pathogens, and so, considerable effort has been put into characterizing their KIR genetics. However, previous studies have relied on cDNA cloning and Sanger sequencing that lack the throughput of current sequencing platforms. In this study, we present a high throughput, full-length allele discovery method utilizing Pacific Biosciences circular consensus sequencing (CCS)...
March 25, 2017: Immunogenetics
https://www.readbyqxmd.com/read/28343228/focal-brain-injury-associated-with-a-model-of-severe-hypoxic-ischemic-encephalopathy-in-nonhuman-primates
#18
Ryan M McAdams, Ronald J McPherson, Raj P Kapur, Sandra E Juul
Worldwide, hypoxic-ischemic encephalopathy (HIE) is a major cause of neonatal mortality and morbidity. To better understand the mechanisms contributing to brain injury and improve outcomes in neonates with HIE, better preclinical animal models that mimic the clinical situation following birth asphyxia in term newborns are needed. In an effort to achieve this goal, we modified our nonhuman primate model of HIE induced by in utero umbilical cord occlusion (UCO) to include postnatal hypoxic episodes, in order to simulate apneic events in human neonates with HIE...
March 25, 2017: Developmental Neuroscience
https://www.readbyqxmd.com/read/28343227/what-is-the-key-to-improving-renal-transplant-recipients-awareness-of-skin-cancer-risk
#19
Alessandro Borghi, Monica Corazza, Yuri Battaglia, Elisa Maietti, Sara Minghetti, Annarosa Virgili
BACKGROUND: Previous studies have shown poor compliance rates regarding sun protection among organ transplant recipients. OBJECTIVE: The main objective of the present study was to assess the awareness among renal transplant recipients (RTRs) of their risk of non-melanoma skin cancer (NMSC) development and their sunscreen use. The influence of several potentially relevant variables was also assessed in order to identify possible weak points on which to concentrate efforts in this respect...
March 25, 2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/28343225/clinical-trial-of-vadadustat-in-patients-with-anemia-secondary-to-stage-3-or-4-chronic-kidney-disease
#20
Edouard R Martin, Mark T Smith, Bradley J Maroni, Qing C Zuraw, Emil M deGoma
BACKGROUND: Therapeutic options for the treatment of anemia secondary to chronic kidney disease (CKD) remain limited. Vadadustat (AKB-6548) is an oral hypoxia-inducible factor prolyl-hydroxylase domain (HIF-PHD) inhibitor that is being investigated for the treatment of anemia secondary to CKD. METHODS: A phase 2a, multicenter, randomized, double-blind, placebo-controlled, dose-ranging trial (NCT01381094) was undertaken in adults with anemia secondary to CKD stage 3 or 4...
March 25, 2017: American Journal of Nephrology
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