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Bioreactance

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https://www.readbyqxmd.com/read/27865658/characterization-of-particulate-phase-polycyclic-aromatic-hydrocarbons-emitted-from-incense-burning-and-their-bioreactivity-in-raw264-7-macrophage
#1
Tzu-Ting Yang, Su-Chen Ho, Lu-Te Chuang, Hsiao-Chi Chuang, Ya-Ting Li, Jyun-Jie Wu
This study investigated the effects of particle-bound polycyclic aromatic hydrocarbons (PAHs) produced from burning three incense types on and their bioreactivity in the RAW 264.7 murine macrophage cell line. Gas chromatography/mass spectrometry was used to determine the levels of 16 identified PAHs. Macrophages were exposed to incense particle extracts at concentrations of 0, 3.125, 6.25, 12.5, 25, 50, and 100 μg/mL for 24 h. After exposure, cell viability and nitric oxide (NO) and inflammatory mediator [tumor necrosis factor (TNF)-α] production of the cells were examined...
January 2017: Environmental Pollution
https://www.readbyqxmd.com/read/27860445/an-in-situ-glucose-stimulated-insulin-secretion-assay-under-perfusion-bioreactor-conditions
#2
Jamie Sharp, Patrick Vermette
Perfusion bioreactors, unlike traditional in vitro cell culture systems, offer stringent control of physiological parameters such as pH, flow, temperature, and dissolved oxygen concentration which have been shown to have an impact on cellular behaviour and viability. Due to the relative infancy and the growing interest in these in vitro culture systems, detection methods to monitor cell function under dynamic perfusion bioreactor conditions remains one of the main challenges. In this study, INS-1 cells, a cell line which exhibit glucose-stimulated insulin secretion, were encapsulated in fibrin and cultured under perfusion bioreactor conditions for 48h and then exposed to either a high-, or low-glucose concentration for 24h...
November 14, 2016: Biotechnology Progress
https://www.readbyqxmd.com/read/27854379/longitudinal-maternal-haemodynamics-in-fetal-growth-restriction-in-pregnancies-at-high-risk-for-placental-insufficiency
#3
Daniel Stott, Papastefanou I, Daniela Paraschiv, Katherine Clark, Nikos A Kametas
OBJECTIVE: Fetal growth restriction is a powerful determinant of poor perinatal outcomes. Our previous work in pregnancies at high risk for the development of hypertension found that early in pregnancy maternal haemodynamics show impaired cardiovascular adaptation in gestations destined to deliver growth-restricted infants. In this study, we serially monitored maternal haemodynamics from the first through to the third trimester in a similar high-risk cohort, in order to determine if, in pregnancies complicated by growth-restriction, these distinct haemodynamic profiles found at presentation persisted throughout pregnancy...
October 31, 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27832567/comparison-of-bioreactance-non-invasive-cardiac-output-measurements-with-cardiac-magnetic-resonance-imaging
#4
F Trinkmann, C Schneider, J D Michels, K Stach, C Doesch, S O Schoenberg, M Borggrefe, J Saur, T Papavassiliu
Impedance cardiography measurement of cardiac output gained wide interest due to its ease of use and non-invasiveness. However, validation studies of different algorithms yielded diverging results. Bioreactance (BR) as a recent adaption differs fundamentally as the flow signal is derived from phase shifts. Our aim was to assess the accuracy and reproducibility of BR, as compared to the non-invasive gold standard--cardiac magnetic resonance imaging (CMR). We prospectively included 32 stable patients. BR was performed twice in the supine position and averaged over 30 seconds...
November 2016: Anaesthesia and Intensive Care
https://www.readbyqxmd.com/read/27778279/activity-based-protein-profiling-with-natural-product-derived-chemical-probes-in-human-cell-lysates
#5
Susanne Zweerink, Tanja Pollmann, Sabrina Ninck, Farnusch Kaschani, Markus Kaiser
Bioreactive natural products represent versatile starting points for the development of structurally unique activity-based probes. In the present protocol, we describe the workflow for an activity-based protein profiling (ABPP) experiment with an alkyne-tagged natural product derivative. Our protocol includes experimental procedures for in vivo labeling, sample preparation and 2-step (click chemistry) visualization and sample preparation for mass spectrometry-based target identification.
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27770202/operational-aspects-of-so2-removal-and-microbial-population-in-an-integrated-bioreactor-with-two-bioreaction-zones
#6
Lin Li, Kaixiong Yang, Jian Lin, Junxin Liu
An integrated-bioreactor, which consisted of a suspended zone and an immobilized zone, was applied to treat gases containing SO2. The removal of SO2 in suspended zone differed slightly from that in immobilized zone. The influences of operational aspects such as SO2 load, temperature, and pH on integrated-bioreactor performance and bacterial community composition were investigated. The synergistic action of the two zones led to effective reduction of SO2, and the total removal efficiencies with the inlet concentration of 91-117 mg/m(3), were over 85 % in steady state...
October 21, 2016: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/27754671/estimation-of-molecular-interaction-force-using-atomic-force-microscopy-for-bioapplication
#7
Hweiyan Tsai, Zihkai Chen, Huiwen Deng, Sinmei Tsai, C Bor Fuh
We report a method that involves using atomic force microscopy to estimate molecular interaction forces for bioapplications. Experimental parameters, comprising the labeling concentrations of tips and substrates and the loading rates of tips, were optimized for estimating molecular interaction forces for three pairs of model molecules (IgG/anti-IgG, BSA/anti-BSA, streptavidin/biotin). The estimated molecular interaction forces of IgG/anti-IgG, BSA/anti-BSA, and streptavidin/biotin were 121 ± 3, 185 ± 4, and 241 ± 4 pN, respectively...
October 18, 2016: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/27749345/agreement-of-bioreactance-cardiac-output-monitoring-with-thermodilution-during-hemorrhagic-shock-and-resuscitation-in-adult-swine
#8
David A Berlin, Harrison Peprah-Mensah, Seth Manoach, Paul M Heerdt
OBJECTIVE: The study tests the hypothesis that noninvasive cardiac output monitoring based upon bioreactance (Cheetah Medical, Portland, OR) has acceptable agreement with intermittent bolus thermodilution over a wide range of cardiac output in an adult porcine model of hemorrhagic shock and resuscitation. DESIGN: Prospective laboratory animal investigation. SETTING: Preclinical university laboratory. SUBJECTS: Eight ~ 50 kg Yorkshire swine with a femoral artery catheter for blood pressure measurement and a pulmonary artery catheter for bolus thermodilution...
October 3, 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27721014/genetically-encoding-new-bioreactivity
#9
Lei Wang
The genetic code can be expanded to include unnatural amino acids (Uaas) by engineering orthogonal components involved in protein translation. To be compatible with live cells, side chains of Uaas have been limited to either chemically inert or bio-orthogonal (i.e., nonreactive toward biomolecules) functionalities. To introduce bioreactivity into live systems, the genetic code has recently been engineered to encode a new class of Uaas, the bioreactive Uaas. These Uaas, after being incorporated into proteins, specifically react with target natural amino acid residues via proximity-enabled bioreactivity, enabling the selective formation of new covalent linkages within and between proteins both in vitro and in live systems...
October 6, 2016: New Biotechnology
https://www.readbyqxmd.com/read/27705969/non-invasive-haemodynamic-monitoring-in-pregnancy-a-comparative-study-using-ultrasound-and-bioreactance
#10
Dimuthu Vinayagam, Sophie Bowe, Elaine Sheehan, Basky Thilaganathan, Asma Khalil
BACKGROUND: Due to the importance of cardiovascular dysfunction and advances in the development and use of non-invasive cardiac output (CO) monitoring devices, there is a growing interest in their use in the obstetric population. The aim of this study was to compare two commercially available, non-invasive CO monitors in the assessment of heart rate (HR), stroke volume (SV), CO, cardiac index (CI) and total peripheral resistance (TPR) in an obstetric population. METHODS: This was a prospective, comparative study including two groups...
October 6, 2016: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/27680814/g3-intraoperative-haemodynamic-monitoring-during-high-risk-caesarean-section-a-comparison-between-bioreactance-nicom-r-and-pressure-waveform-analysis-lidcorapidr-preliminary-results
#11
D Vinayagam, S Bampoe, B Thilaganathan, A Khalil
BACKGROUND: Intraoperative haemodynamic monitoring is carried out in high-risk surgical patients, often using invasive methods, including pulmonary artery catheterisation. Early goal-directed therapy in high-risk surgical patients reduces tissue hypoxia, organ failure and improves outcomes. Significant maternal morbidity arises as a result of perioperative haemorrhage. At present, heart rate and brachial blood pressure are used as proxy markers to aid in fluid resuscitation, however, we know that these exhibit minimal change during early stages of shock, and are poor indicators of the adequacy of therapeutic intervention...
August 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27646677/improving-icsi-a-review-from-the-spermatozoon-perspective
#12
Mara Simopoulou, Laertis Gkoles, Panagiotis Bakas, Polina Giannelou, Theodoros Kalampokas, Konstantinos Pantos, Michael Koutsilieris
: Intracytoplasmic sperm injection (ICSI) is the most frequently applied method for fertilization making the process of identifying the perfect spermatozoon fundamental. Herein we offer a critical and thorough presentation on the techniques reported regarding (i) handling and preparing semen samples, (ii) identifying and 'fishing' spermatozoa, and (iii) improving key factors, such as motility for a successful ICSI practice. These approaches are suggested to make the process easier and more effective especially in atypical and challenging circumstances...
December 2016: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/27575855/pkc-aldh2-pathway-plays-a-novel-role-in-adipocyte-differentiation
#13
Yu-Hsiang Yu, Pei-Ru Liao, Chien-Jung Guo, Che-Hong Chen, Daria Mochly-Rosen, Lee-Ming Chuang
The ALDH2 gene encodes the mitochondrial aldehyde dehydrogenase 2 (ALDH2), a critical enzyme involved in ethanol clearance through acetaldehyde metabolism. ALDH2 also catalyzes the metabolism of other bioreactive aldehydes, including propionaldehyde, butyraldehyde, and 4-hydroxykenals (4-HNE). Increased levels of 4-HNE in adipose tissue positively correlate with obesity and insulin resistance. However, it remains unclear whether ALDH2 is involved in regulation of adipocyte differentiation. Here, we found that ALDH2 protein levels were lower in white adipose tissue of high-fat diet-fed mice and ob/ob mice relative to lean mice...
2016: PloS One
https://www.readbyqxmd.com/read/27499822/particle-disease-a-current-review-of-the-biological-mechanisms-in-periprosthetic-osteolysis-after-hip-arthroplasty
#14
Erhan Sukur, Yunus Emre Akman, Yusuf Ozturkmen, Fatih Kucukdurmaz
BACKGROUND: Inflammatory responses to wear debris cause osteolysis that leads to aseptic prosthesis loosening and hip arthroplasty failure. Although osteolysis is usually associated with aseptic loosening, it is rarely seen around stable implants. Aseptic implant loosening is a simple radiologic phenomenon, but a complex immunological process. Particulate debris produced by implants most commonly causes osteolysis, and this is called particle-associated periprosthetic osteolysis (PPO)...
2016: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/27497232/nanocrystallinity-effects-on-osteoblast-and-osteoclast-response-to-silicon-substituted-hydroxyapatite
#15
Laura Casarrubios, María Concepción Matesanz, Sandra Sánchez-Salcedo, Daniel Arcos, María Vallet-Regí, María Teresa Portolés
HYPOTHESIS: Silicon substituted hydroxyapatites (SiHA) are highly crystalline bioceramics treated at high temperatures (about 1200°C) which have been approved for clinical use with spinal, orthopedic, periodontal, oral and craniomaxillofacial applications. The preparation of SiHA with lower temperature methods (about 700°C) provides nanocrystalline SiHA (nano-SiHA) with enhanced bioreactivity due to higher surface area and smaller crystal size. The aim of this study has been to know the nanocrystallinity effects on the response of both osteoblasts and osteoclasts (the two main cell types involved in bone remodelling) to silicon substituted hydroxyapatite...
November 15, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27467577/cobalt-alloy-implant-debris-induces-inflammation-and-bone-loss-primarily-through-danger-signaling-not-tlr4-activation-implications-for-damp-ening-implant-related-inflammation
#16
Lauryn Samelko, Stefan Landgraeber, Kyron McAllister, Joshua Jacobs, Nadim James Hallab
Cobalt alloy debris has been implicated as causative in the early failure of some designs of current total joint implants. The ability of implant debris to cause excessive inflammation via danger signaling (NLRP3 inflammasome) vs. pathogen associated pattern recognition receptors (e.g. Toll-like receptors; TLRs) remains controversial. Recently, specific non-conserved histidines on human TLR4 have been shown activated by cobalt and nickel ions in solution. However, whether this TLR activation is directly or indirectly an effect of metals or secondary endogenous alarmins (danger-associated molecular patterns, DAMPs) elicited by danger signaling, remains unknown and contentious...
2016: PloS One
https://www.readbyqxmd.com/read/27465979/a-prediction-model-for-the-response-to-oral-labetalol-for-the-treatment-of-antenatal-hypertension
#17
D Stott, M Bolten, M Salman, D Paraschiv, A Douiri, N A Kametas
This prospective observational study aimed to identify at presentation the maternal hemodynamic and demographic variables associated with a therapeutic response to oral labetalol and to use these variables to develop a prediction model to anticipate the response to labetalol monotherapy in women with hypertension. It was set at a maternity unit in a UK teaching hospital. Maternal demographic data from 50 pregnant women, presenting with hypertension between January and August 2013, was collected and blood pressure measured with a device validated for pregnancy and pre-eclampsia...
July 28, 2016: Journal of Human Hypertension
https://www.readbyqxmd.com/read/27461188/evaluation-of-cardiac-output-by-bioreactance-technique-in-patients-undergoing-liver-transplantation
#18
Po-Yuan Shih, Wen-Ying Lin, Ming-Hui Hung, Ya-Jung Cheng, Kuang-Cheng Chan
BACKGROUND: This study compared the cardiac output (CO) obtained from PiCCO with that obtained from the noninvasive NICOM method. METHODS: Twenty-one cirrhotic patients receiving liver transplantation were enrolled. During the operation, their CO was measured by the PiCCO system via the thermodilution method as the standard and by the NICOM method. Two parameters including cardiac index (CI) and stroke volume index (SVI) were collected simultaneously at three phases during the surgery including the dissection phase (T1), the anhepatic phase (T2), and the reperfusion phase (T3)...
June 2016: Acta Anaesthesiologica Taiwanica: Official Journal of the Taiwan Society of Anesthesiologists
https://www.readbyqxmd.com/read/27441789/effect-of-pulmonary-surfactant-on-the-dissolution-stability-and-uptake-of-zinc-oxide-nanowires-by-human-respiratory-epithelial-cells
#19
Ioannis G Theodorou, Pakatip Ruenraroengsak, Andrew Gow, Stephan Schwander, Junfeng Jim Zhang, Kian Fan Chung, Teresa D Tetley, Mary P Ryan, Alexandra E Porter
Inhaled nanoparticles (NPs) have high-deposition rates in the alveolar region of the lung but the effects of pulmonary surfactant (PS) on nanoparticle bioreactivity are unclear. Here, the impact of PS on the stability and dissolution of ZnO nanowires (ZnONWs) was investigated, and linked with their bioreactivity in vitro with human alveolar epithelial type 1-like cells (TT1). Pre-incubation of ZnONWs with Curosurf® (a natural porcine PS) decreased their dissolution at acidic pH, through the formation of a phospholipid corona...
November 2016: Nanotoxicology
https://www.readbyqxmd.com/read/27343827/exposure-time-based-modeling-of-nonlinear-reactive-transport-in-porous-media-subject-to-physical-and-geochemical-heterogeneity
#20
Alicia Sanz-Prat, Chuanhe Lu, Richard T Amos, Michael Finkel, David W Blowes, Olaf A Cirpka
Transport of reactive solutes in groundwater is affected by physical and chemical heterogeneity of the porous medium, leading to complex spatio-temporal patterns of concentrations and reaction rates. For certain cases of bioreactive transport, it could be shown that the concentrations of reactive constituents in multi-dimensional domains are approximately aligned with isochrones, that is, lines of identical travel time, provided that the chemical properties of the matrix are uniform. We extend this concept to combined physical and chemical heterogeneity by additionally considering the time that a water parcel has been exposed to reactive materials, the so-called exposure time...
September 2016: Journal of Contaminant Hydrology
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