Pang-Ning Teng, Waleed Barakat, Sophie M Tran, Zoe M Tran, Nicholas W Bateman, Kelly A Conrads, Katlin N Wilson, Julie Oliver, Glenn Gist, Brian L Hood, Ming Zhou, G Larry Maxwell, Lorenzo Leggio, Thomas P Conrads, Mary R Lee
Alcohol use disorder (AUD) affects transcriptomic, epigenetic and proteomic expression in several organs, including the brain. There has not been a comprehensive analysis of altered protein abundance focusing on the multiple brain regions that undergo neuroadaptations occurring in AUD. We performed a quantitative proteomic analysis using a liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis of human postmortem tissue from brain regions that play key roles in the development and maintenance of AUD, the amygdala (AMG), hippocampus (HIPP), hypothalamus (HYP), nucleus accumbens (NAc), prefrontal cortex (PFC) and ventral tegmental area (VTA)...
October 13, 2023: Translational Psychiatry