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Tissue engineered heart valves

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https://www.readbyqxmd.com/read/28890780/recellularization-of-decellularized-heart-valves-progress-toward-the-tissue-engineered-heart-valve
#1
REVIEW
Mitchell C VeDepo, Michael S Detamore, Richard A Hopkins, Gabriel L Converse
The tissue-engineered heart valve portends a new era in the field of valve replacement. Decellularized heart valves are of great interest as a scaffold for the tissue-engineered heart valve due to their naturally bioactive composition, clinical relevance as a stand-alone implant, and partial recellularization in vivo. However, a significant challenge remains in realizing the tissue-engineered heart valve: assuring consistent recellularization of the entire valve leaflets by phenotypically appropriate cells...
January 2017: Journal of Tissue Engineering
https://www.readbyqxmd.com/read/28854488/histological-and-biomechanical-characterization-of-decellularized-porcine-pericardium-as-a-potential-scaffold-for-tissue-engineering-applications
#2
Panagiotis Mallis, Efstathios Michalopoulos, Constantine Dimitriou, Nikolaos Kostomitsopoulos, Catherine Stavropoulos-Giokas
BACKGROUND: Each year, more than 800,000 vascular and cardiac surgeries are performed therefore, there is a great need for suitable material for bioprosthetic operations. Porcine pericardium is a double-walled sac that covers the heart and can be used in vascular and cardiac thoracic surgery. OBJECTIVE: The aim of the present study was to evaluate the decellularization process and biomechanical properties in porcine pericardial tissue after the decellularization treatment...
2017: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/28783560/a-study-of-extracellular-matrix-remodeling-in-aortic-heart-valves-using-a-novel-biaxial-stretch-bioreactor
#3
Ying Lei, Shirin Masjedi, Zannatul Ferdous
In aortic valves, biaxial cyclic stretch is known to modulate cell differentiation, extracellular matrix (ECM) synthesis and organization. We designed a novel bioreactor that can apply independent and precise stretch along radial and circumferential directions in a tissue culture environment. While this bioreactor can be used for either native or engineered tissues, this study determined matrix remodeling and strain distribution of aortic cusps after culturing under biaxial stretch for 14 days. The contents of collagen and glycosaminoglycans were determined using standard biochemical assays and compared with fresh controls...
July 27, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28782585/weaving-for-heart-valve-tissue-engineering
#4
REVIEW
Albert Liberski, Nadia Ayad, Dorota Wojciechowska, Radoslaw Kot, Duy M P Vo, Dilibaier Aibibu, Gerald Hoffmann, Chokri Cherif, Katharina Grobelny-Mayer, Marek Snycerski, Helmut Goldmann
Weaving is a resourceful technology which offers a large selection of solutions that are readily adaptable for tissue engineering (TE) of artificial heart valves (HV). The different ways that the yarns are interlaced in this technique could be used to produce complex architectures, such as the three-layer architecture of the leaflets. Once the assembly is complete, growth of cells in the scaffold would occur in the orientation of the yarn, enabling the deposition of extra cellular matrixes proteins in an oriented manner...
August 4, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/28782083/current-challenges-in-translating-tissue-engineered-heart-valves
#5
REVIEW
O M J A Stassen, D E P Muylaert, C V C Bouten, J Hjortnaes
Heart valve disease is a major health burden, treated by either valve repair or valve replacement, depending on the affected valve. Nearly 300,000 valve replacements are performed worldwide per year. Valve replacement is lifesaving, but not without complications. The in situ tissue-engineered heart valve is a promising alternative to current treatments, but the translation of this novel technology to the clinic still faces several challenges. These challenges originate from the variety encountered in the patient population, the conversion of an implant into a living tissue, the highly mechanical nature of the heart valve, the complex homeostatic tissue that has to be reached at the end stage of the regenerating heart valve, and all the biomaterial properties that can be controlled to obtain this tissue...
September 2017: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28763463/recellularization-of-a-novel-off-the-shelf-valve-following-xenogenic-implantation-into-the-right-ventricular-outflow-tract
#6
Ryan S Hennessy, Jason L Go, Rebecca R Hennessy, Brandon J Tefft, Soumen Jana, Nicholas J Stoyles, Mohammed A Al-Hijji, Jeremy J Thaden, Sorin V Pislaru, Robert D Simari, John M Stulak, Melissa D Young, Amir Lerman
Current research on valvular heart repair has focused on tissue-engineered heart valves (TEHV) because of its potential to grow similarly to native heart valves. Decellularized xenografts are a promising solution; however, host recellularization remains challenging. In this study, decellularized porcine aortic valves were implanted into the right ventricular outflow tract (RVOT) of sheep to investigate recellularization potential. Porcine aortic valves, decellularized with sodium dodecyl sulfate (SDS), were sterilized by supercritical carbon dioxide (scCO2) and implanted into the RVOT of five juvenile polypay sheep for 5 months (n = 5)...
2017: PloS One
https://www.readbyqxmd.com/read/28758358/freeze-drying-as-a-novel-biofabrication-method-for-achieving-a-controlled-microarchitecture-within-large-complex-natural-biomaterial-scaffolds
#7
Claire M Brougham, Tanya J Levingstone, Nian Shen, Gerard M Cooney, Stefan Jockenhoevel, Thomas C Flanagan, Fergal J O'Brien
The biofabrication of large natural biomaterial scaffolds into complex 3D shapes which have a controlled microarchitecture remains a major challenge. Freeze-drying (or lyophilization) is a technique used to generate scaffolds in planar 3D geometries. Here we report the development of a new biofabrication process to form a collagen-based scaffold into a large, complex geometry which has a large height to width ratio, and a controlled porous microarchitecture. This biofabrication process is validated through the successful development of a heart valve shaped scaffold, fabricated from a collagen-glycosaminoglycan co-polymer...
July 31, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28745279/paediatric-nanofibrous-bioprosthetic-heart-valve
#8
REVIEW
Mehrdad Namdari, Babak Negahdari, Ali Eatemadi
The search for an optimal aortic valve implant with durability, calcification resistance, excellent haemodynamic parameters and ability to withstand mechanical loading is yet to be met. Thus, there has been struggled to fabricate bio-prosthetics heart valve using bioengineering. The consequential product must be resilient with suitable mechanical features, biocompatible and possess the capacity to grow. Defective heart valves replacement by surgery is now common, this improves the value and survival of life for a lot of patients...
August 2017: IET Nanobiotechnology
https://www.readbyqxmd.com/read/28532900/combinatorial-screening-of-3d-biomaterial-properties-that-promote-myofibrogenesis-for-mesenchymal-stromal-cell-based-heart-valve-tissue-engineering
#9
Jenna Usprech, David A Romero, Cristina H Amon, Craig A Simmons
The physical and chemical properties of a biomaterial integrate with soluble cues in the cell microenvironment to direct cell fate and function. Predictable biomaterial-based control of integrated cell responses has been investigated with two-dimensional (2D) screening platforms, but integrated responses in 3D have largely not been explored systematically. To address this need, we developed a screening platform using polyethylene glycol norbornene (PEG-NB) as a model biomaterial with which the polymer wt% (to control elastic modulus) and adhesion peptide types (RGD, DGEA, YIGSR) and densities could be controlled independently and combinatorially in arrays of 3D hydrogels...
May 19, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28516795/a-comprehensive-guide-to-telocytes-and-their-great-potential-in-cardiovascular-system
#10
REVIEW
I Kucybala, P Janas, S Ciuk, W Cholopiak, W Klimek-Piotrowska, M K Holda
Telocytes, a recently discovered type of interstitial cells, have a very distinctive morphology - the small cell body with long extensions, named telopodes. In our review, apart from introducing general aspects of telocytes, we focus on properties, functions and future potential of those cells in cardiovascular system. However, physiological functions of telocytes in cardiovascular system are still regarded as quite enigmatic. Previous studies claim that they play a role in organogenesis and regeneration, bioelectrical signalling, mechanoelectrical coupling, anti-oxidative protection, angiogenesis and regulation of blood flow...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/28482571/optimization-and-development-of-maghemite-%C3%AE-fe2o3-filled-poly-l-lactic-acid-plla-thermoplastic-polyurethane-tpu-electrospun-nanofibers-using-taguchi-orthogonal-array-for-tissue-engineering-heart-valve
#11
Ehsan Fallahiarezoudar, Mohaddeseh Ahmadipourroudposht, Ani Idris, Noordin Mohd Yusof
Tissue engineering (TE) is an advanced principle to develop a neotissue that can resemble the original tissue characteristics with the capacity to grow, to repair and to remodel in vivo. This research proposed the optimization and development of nanofiber based scaffold using the new mixture of maghemite (γ-Fe2O3) filled poly-l-lactic acid (PLLA)/thermoplastic polyurethane (TPU) for tissue engineering heart valve (TEHV). The chemical, structural, biological and mechanical properties of nanofiber based scaffold were characterized in terms of morphology, porosity, biocompatibility and mechanical behaviour...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28453437/umbilical-cord-as-human-cell-source-for-mitral-valve-tissue-engineering-venous-vs-arterial-cells
#12
Axel Malischewski, Ricardo Moreira, Luis Hurtado, Valentine Gesché, Thomas Schmitz-Rode, Stefan Jockenhoevel, Petra Mela
Around 2% of the population in developed nations are affected by mitral valve disease and available valvular replacements are not designed for the atrioventricular position. Recently our group developed the first tissue-engineered heart valve (TEHV) specifically designed for the mitral position - the TexMi valve. The valve recapitulates the main components of the native valve, i.e. annulus, asymmetric leaflets and the crucial chordae tendineae. In the present study, we evaluated the human umbilical cord as a clinically applicable cell source for the TexMi valve...
April 28, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28445803/jetvalve-rapid-manufacturing-of-biohybrid-scaffolds-for-biomimetic-heart-valve-replacement
#13
Andrew K Capulli, Maximillian Y Emmert, Francesco S Pasqualini, Debora Kehl, Etem Caliskan, Johan U Lind, Sean P Sheehy, Sung Jin Park, Seungkuk Ahn, Benedikt Weber, Josue A Goss, Simon P Hoerstrup, Kevin Kit Parker
Tissue engineered scaffolds have emerged as a promising solution for heart valve replacement because of their potential for regeneration. However, traditional heart valve tissue engineering has relied on resource-intensive, cell-based manufacturing, which increases cost and hinders clinical translation. To overcome these limitations, in situ tissue engineering approaches aim to develop scaffold materials and manufacturing processes that elicit endogenous tissue remodeling and repair. Yet despite recent advances in synthetic materials manufacturing, there remains a lack of cell-free, automated approaches for rapidly producing biomimetic heart valve scaffolds...
July 2017: Biomaterials
https://www.readbyqxmd.com/read/28362047/the-vietnamese-pig-as-a-translational-animal-model-to-evaluate-tissue-engineered-heart-valves-promising-early-experience
#14
Michele Gallo, Helen Poser, Tommaso Bottio, Antonella Bonetti, Paolo Franci, Filippo Naso, Edward Buratto, Fabio Zanella, Giovanni Perona, Carlo Dal Lin, Roberto Bianco, Michele Spina, Roberto Busetto, Maurizio Marchini, Fulvia Ortolani, Laura Iop, Gino Gerosa
Several animal models are currently used for the surgical implantation of either biologic or biopolymeric scaffolds in order to provide in vivo assessment of tissue-engineered heart valves. The Vietnamese pig (VP) is herein proposed as a suitable recipient to test the function of novel bioengineered valve substitutes, in the reconstruction of the right ventricular outflow tract (RVOT). This review aims to provide a complete and exhaustive panel of physiological parameters and methodological information for preclinical studies of tissue-engineered heart valves in the VP animal model...
May 9, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28314377/the-effects-of-scaffold-remnants-in-decellularized-tissue-engineered-cardiovascular-constructs-on-the-recruitment-of-blood-cells
#15
Bart Sanders, Anita Driessen-Mol, Carlijn V C Bouten, Frank P T Baaijens
Decellularized tissue-engineered heart valves (DTEHVs) showed remarkable results in translational animal models, leading to recellularization within hours after implantation. This is crucial to enable tissue remodeling. To investigate if the presence of scaffold remnants before implantation is responsible for the fast recellularization of DTEHVs, an in vitro mesofluidic system was used. Human granulocyte and agranulocyte fractions were isolated, stained, brought back in suspension, and implemented in the system...
April 14, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28289246/the-heart-and-great-vessels
#16
Ekene Onwuka, Nakesha King, Eric Heuer, Christopher Breuer
Cardiovascular disease is the leading cause of mortality worldwide. We have made large strides over the past few decades in management, but definitive therapeutic options to address this health-care burden are still limited. Given the ever-increasing need, much effort has been spent creating engineered tissue to replaced diseased tissue. This article gives a general overview of this work as it pertains to the development of great vessels, myocardium, and heart valves. In each area, we focus on currently studied methods, limitations, and areas for future study...
March 13, 2017: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/28253994/in-situ-heart-valve-tissue-engineering-using-a-bioresorbable-elastomeric-implant-from-material-design-to-12-months-follow-up-in-sheep
#17
Jolanda Kluin, Hanna Talacua, Anthal I P M Smits, Maximilian Y Emmert, Marieke C P Brugmans, Emanuela S Fioretta, Petra E Dijkman, Serge H M Söntjens, Renée Duijvelshoff, Sylvia Dekker, Marloes W J T Janssen-van den Broek, Valentina Lintas, Aryan Vink, Simon P Hoerstrup, Henk M Janssen, Patricia Y W Dankers, Frank P T Baaijens, Carlijn V C Bouten
The creation of a living heart valve is a much-wanted alternative for current valve prostheses that suffer from limited durability and thromboembolic complications. Current strategies to create such valves, however, require the use of cells for in vitro culture, or decellularized human- or animal-derived donor tissue for in situ engineering. Here, we propose and demonstrate proof-of-concept of in situ heart valve tissue engineering using a synthetic approach, in which a cell-free, slow degrading elastomeric valvular implant is populated by endogenous cells to form new valvular tissue inside the heart...
May 2017: Biomaterials
https://www.readbyqxmd.com/read/28219851/understanding-the-requirements-of-self-expandable-stents-for-heart-valve-replacement-radial-force-hoop-force-and-equilibrium
#18
María Sol Cabrera, Cees W J Oomens, Frank P T Baaijens
A proper interpretation of the forces developed during stent crimping and deployment is of paramount importance for a better understanding of the requirements for successful heart valve replacement. The present study combines experimental and computational methods to assess the performance of a nitinol stent for tissue-engineered heart valve implantation. To validate the stent model, the mechanical response to parallel plate compression and radial crimping was evaluated experimentally. Finite element simulations showed good agreement with the experimental findings...
February 7, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28183649/biological-and-mechanical-evaluation-of-a-bio-hybrid-scaffold-for-autologous-valve-tissue-engineering
#19
S Jahnavi, U Saravanan, N Arthi, G S Bhuvaneshwar, T V Kumary, S Rajan, R S Verma
Major challenge in heart valve tissue engineering for paediatric patients is the development of an autologous valve with regenerative capacity. Hybrid tissue engineering approach is recently gaining popularity to design scaffolds with desired biological and mechanical properties that can remodel post implantation. In this study, we fabricated aligned nanofibrous Bio-Hybrid scaffold made of decellularized bovine pericardium: polycaprolactone-chitosan with optimized polymer thickness to yield the desired biological and mechanical properties...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28178887/magnesium-presence-prevents-removal-of-antigenic-nuclear-associated-proteins-from-bovine-pericardium-for-heart-valve-engineering
#20
Ailsa J Dalgliesh, Zhi Zhao Liu, Leigh G Griffiths
Current heart valve prostheses are associated with significant complications, including aggressive immune response, limited valve life expectancy, and inability to grow in juvenile patients. Animal derived "tissue" valves undergo glutaraldehyde fixation to mask tissue antigenicity; however, chronic immunological responses and associated calcification still commonly occur. A heart valve formed from an unfixed bovine pericardium (BP) extracellular matrix (ECM) scaffold, in which antigenic burden has been eliminated or significantly reduced, has potential to overcome deficiencies of current bioprostheses...
July 2017: Tissue Engineering. Part A
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