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https://www.readbyqxmd.com/read/29928883/suppression-of-cleavage-factor-im-25-promotes-the-proliferation-of-lung-cancer-cells-through-alternative-polyadenylation
#1
Jingjing Huang, Tingting Weng, Junsuk Ko, Ning-Yuan Chen, Yu Xiang, Kelly Volcik, Leng Han, Michael R Blackburn, Xiang Lu
BACKGROUND: Non-small cell lung cancer (NSCLC) is a life-threatening disease that has a poor prognosis and low survival rate. Cleavage factor Im 25 (CFIm25) is a RNA-binding protein that if down-regulated causes 3'UTR shortening and thus promotes the transcript stability of target genes. It is not clear whether CFIm25 and alternative polyadenylation (APA) play a role during cancer development. The purpose of this study is to explore the role of CFIm25 in lung cancer cell proliferation...
June 18, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29928469/high-frequency-of-pathogenic-non-founder-germline-mutations-in-brca1-and-brca2-in-families-with-breast-and-ovarian-cancer-in-a-founder-population
#2
J Maksimenko, A Irmejs, G Trofimovičs, D Bērziņa, E Skuja, G Purkalne, E Miklaševičs, J Gardovskis
Background: Pathogenic BRCA1 founder mutations (c.4035delA, c.5266dupC) contribute to 3.77% of all consecutive primary breast cancers and 9.9% of all consecutive primary ovarian cancers. Identifying germline pathogenic gene variants in patients with primary breast and ovarian cancer could significantly impact the medical management of patients. The aim of the study was to evaluate the rate of pathogenic mutations in the 26 breast and ovarian cancer susceptibility genes in patients who meet the criteria for BRCA1/2 testing and to compare the accuracy of different selection criteria for second-line testing in a founder population...
2018: Hereditary Cancer in Clinical Practice
https://www.readbyqxmd.com/read/29928431/p53-positively-regulates-the-expression-of-cancer-stem-cell-marker-cd133-in-hct116-colon-cancer-cells
#3
Xia Chen, Hua Guan, Xiao-Dan Liu, Da-Fei Xie, Yu Wang, Teng Ma, Bo Huang, Ping-Kun Zhou
Colon cancer stem cells (CSCs), which are highly capable of self-renewal and proliferation, are involved in colon tumorigenesis and response to therapy. CD133 is considered the most robust surface marker for colorectal cancer stem cells. Although the TP53 gene is frequently mutated in colon cancer, it remains not fully understood whether and how tumor protein p53 (p53) is associated with CD133 expression in colon cancer cells. In the present study, the expression of the CSC biomarker CD133 was investigated in terms of p53 status in colorectal carcinoma HCT116 cells...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928384/-tp53-mutations-and-snps-as-prognostic-and-predictive-factors-in-patients-with-breast-cancer
#4
REVIEW
Joanna Huszno, Ewa Grzybowska
Tumor protein 53 ( TP53 ) is a tumor suppressor gene that encodes tumor protein p53. Tumor protein p53 regulates the expression of target genes in response to cellular stress. Additionally, p53 participates in the regulation of cell cycle checkpoints, DNA repair and apoptosis. Mutations in the TP53 gene are associated with numerous types of human cancer, including breast cancer, sarcomas, brain tumors and adrenal cortical carcinomas. In breast cancer, TP53 mutations are a negative prognostic factor. Tumors with TP53 mutations are more likely to be aggressive (triple-negative or human epidermal growth factor receptor 2-positive breast cancer), and resistant to chemotherapy and radiotherapy...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29926297/breast-cancer-in-women-with-neurofibromatosis-type-1-nf1-a-comprehensive-case-series-with-molecular-insights-into-its-aggressive-phenotype
#5
Yoon-Sim Yap, Prabhakaran Munusamy, Cindy Lim, Claire H T Chan, Aldo Prawira, Sau-Yeen Loke, Swee-Ho Lim, Kong-Wee Ong, Wei-Sean Yong, Sarah B H Ng, Iain B H Tan, David F Callen, Jeffrey C T Lim, Aye-Aye Thike, Puay-Hoon Tan, Ann S G Lee
PURPOSE: The purpose of the study was to improve the understanding of NF1-associated breast cancer, given the increased risk of breast cancer in this tumour predisposition syndrome and the limited data. METHODS: We identified 18 women with NF1 and breast cancer at our institution. Clinical and pathologic characteristics of NF1-associated breast cancers were compared with 7132 breast cancers in patients without NF1 from our institutional database. Next generation sequencing was performed on DNA from blood and breast cancer specimens available...
June 21, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29924804/reporters-to-mark-and-eliminate-basal-or-luminal-epithelial-cells-in-culture-and-in-vivo
#6
Olmo Sonzogni, Jennifer Haynes, Laurie A Seifried, Yahia M Kamel, Kai Huang, Michael D BeGora, Faith Au Yeung, Celine Robert-Tissot, Yujing J Heng, Xin Yuan, Gerbug M Wulf, Ken J Kron, Elvin Wagenblast, Mathieu Lupien, Thomas Kislinger, Gregory J Hannon, Senthil K Muthuswamy
The contribution of basal and luminal cells to cancer progression and metastasis is poorly understood. We report generation of reporter systems driven by either keratin-14 (K14) or keratin-8 (K8) promoter that not only express a fluorescent protein but also an inducible suicide gene. Transgenic mice express the reporter genes in the right cell compartments of mammary gland epithelia and respond to treatment with toxins. In addition, we engineered the reporters into 4T1 metastatic mouse tumor cell line and demonstrate that K14+ cells, but not K14- or K8+, are both highly invasive in three-dimensional (3D) culture and metastatic in vivo...
June 20, 2018: PLoS Biology
https://www.readbyqxmd.com/read/29923368/human-electronegative-ldl-induces-mitochondrial-dysfunction-and-premature-senescence-of-vascular-cells-in-vivo
#7
Yu-Chen Wang, An-Sheng Lee, Long-Sheng Lu, Liang-Yin Ke, Wei-Yu Chen, Jian-Wen Dong, Jonathan Lu, Zhenping Chen, Chih-Sheng Chu, Hua-Chen Chan, Taha Y Kuzan, Ming-Hsien Tsai, Wen-Li Hsu, Richard A F Dixon, Tatsuya Sawamura, Kuan-Cheng Chang, Chu-Huang Chen
Dysregulation of plasma lipids is associated with age-related cardiovascular diseases. L5, the most electronegative subfraction of chromatographically resolved low-density lipoprotein (LDL), induces endothelial dysfunction, whereas the least electronegative subfraction, L1, does not. In this study, we examined the effects of L5 on endothelial senescence and its underlying mechanisms. C57B6/J mice were intravenously injected with L5 or L1 (2 mg kg-1  day-1 ) from human plasma. After 4 weeks, nuclear γH2AX deposition and senescence-associated β-galactosidase staining indicative of DNA damage and premature senescence, respectively, were increased in the aortic endothelium of L5-treated but not L1-treated mice...
June 19, 2018: Aging Cell
https://www.readbyqxmd.com/read/29922827/association-between-inherited-germline-mutations-in-cancer-predisposition-genes-and-risk-of-pancreatic-cancer
#8
Chunling Hu, Steven N Hart, Eric C Polley, Rohan Gnanaolivu, Hermela Shimelis, Kun Y Lee, Jenna Lilyquist, Jie Na, Raymond Moore, Samuel O Antwi, William R Bamlet, Kari G Chaffee, John DiCarlo, Zhong Wu, Raed Samara, Pashtoon M Kasi, Robert R McWilliams, Gloria M Petersen, Fergus J Couch
Importance: Individuals genetically predisposed to pancreatic cancer may benefit from early detection. Genes that predispose to pancreatic cancer and the risks of pancreatic cancer associated with mutations in these genes are not well defined. Objective: To determine whether inherited germline mutations in cancer predisposition genes are associated with increased risks of pancreatic cancer. Design, Setting, and Participants: Case-control analysis to identify pancreatic cancer predisposition genes; longitudinal analysis of patients with pancreatic cancer for prognosis...
June 19, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29921697/inactivation-of-citron-kinase-inhibits-medulloblastoma-progression-by-inducing-apoptosis-and-cell-senescence
#9
Gianmarco Pallavicini, Francesco Sgro, Francesca Garello, Mattia Falcone, Valeria Bitonto, Gaia E Berto, Federico T Bianchi, Marta Gai, Alessandra Ma Chiotto, Miriam Filippi, Juan C Cutrin, Ugo Ala, Enzo Terreno, Emilia Turco, Ferdinando Di Cunto
Medulloblastoma (MB) is the most common malignant brain tumor in children. Current treatment for MB consists of surgery followed by irradiation of the whole neuraxis and high-dose multi-agent chemotherapy, a partially effective strategy associated with highly invalidating side effects. Therefore, identification and validation of novel target molecules capable of contrasting MB growth without disturbing brain development is needed. Citron kinase protein (CITK), encoded by primary microcephaly gene MCPH17, is required for normal proliferation and survival of neural progenitors...
June 19, 2018: Cancer Research
https://www.readbyqxmd.com/read/29921694/attenuated-traf3-fosters-alternative-activation-of-nf-%C3%AE%C2%BAb-and-reduced-expression-of-anti-viral-interferon-tp53-and-rb-to-promote-hpv-positive-head-and-neck-cancers
#10
Jialing Zhang, Tony Chen, Xinping Yang, Hui Cheng, Stephan S Späth, Paul E Clavijo, Jianhong Chen, Christopher Silvin, Natalia Issaeva, Xiulan Su, Wendell G Yarbrough, Christina M Annunziata, Zhong Chen, Carter Van Waes
Human papilloma viruses (HPV) are linked to an epidemic increase in oropharyngeal head and neck squamous cell carcinomas (HNSCC), which display viral inactivation of tumor suppressors TP53 and RB1 and rapid regional spread. However, the role of genomic alterations in enabling modulation of pathways that promote the aggressive phenotype of these cancers is unclear. Recently, a subset of HPV+ HNSCC has been shown to harbor novel genetic defects or decreased expression of TNF-receptor-associated-factor-3 (TRAF3)...
June 19, 2018: Cancer Research
https://www.readbyqxmd.com/read/29915797/impact-of-lower-uterine-segment-involvement-in-type-ii-endometrial-cancer-and-the-unique-mutational-profile-of-serous-tumors
#11
Liron Kogan, David Octeau, Zainab Amajoud, Jeremie Abitbol, Ido Laskov, Alex Ferenczy, Manuela Pelmus, Neta Eisenberg, Roy Kessous, Susie Lau, Amber Yasmeen, Walter H Gotlieb, Shannon Salvador
Objective: Evaluation of the impact of lower uterine segment involvement (LUSI) in type II endometrial cancer, and mutational profile of uterine papillary serous carcinomas (UPSC). Methods: Retrospective cohort study comparing patients with type II endometrial cancer with LUSI to patients without LUSI. Genes commonly implicated in carcinogenesis were analyzed in a subgroup of 42 patients with UPSC using next generation sequencing. Results: 83 patients with type II endometrial cancer were included in the study, of these, LUSI was diagnosed in 31...
May 2018: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/29914973/circulating-tumor-dna-detectable-in-early-and-late-stage-colorectal-cancer-patients
#12
Ying-Chi Yang, Dong Wang, Lan Jin, Hong-Wei Yao, Jing-Hui Zhang, Jin Wang, Xiao-Mu Zhao, Chun-Ying Shen, Wei Chen, Xue-Liang Wang, Rong Shi, Si-Yi Chen, Zhong-Tao Zhang
Characterization, diagnosis, and treatment of colorectal cancers (CRC) are difficult due to limited biopsy information, impracticality of repeated biopsies, and cancer biomarker fallibility. Circulating tumor DNA (ctDNA) has recently been investigated as a non-invasive way to gain representative gene mutations in tumors, in addition to monitoring disease progression and response to treatment. We analyzed ctDNA mutations and concentrations in 47 early- and late-stage CRC patients using a targeted sequencing approach using a panel that covers 50 cancer-related genes...
June 18, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29910852/biochemical-pathway-analysis-of-gastric-atrophy
#13
Mostafa Rezaei Tavirani, Sina Rezaei Tavirani, Fatemeh Tajik Rostami
Aim: Pathway analysis of gastric atrophy to find new molecular prospective of disease. Background: Gastric atrophy as a process which is accompanied with "loss of glans" in stomach can be considered as a risk factor of gastric cancer. Here, the correlated biochemical pathways to the disorder have been analyzed via protein-protein interaction (PPI) network analysis. Methods: The genes related to gastric atrophy were retrieved by STRING database and organized in a network by Cytoscape...
2018: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/29906465/mirna-mediated-apoptosis-activation-through-tmem-48-inhibition-in-a549-cell-line
#14
Feridun Akkafa, İsmail Koyuncu, Ebru Temiz, Hasan Dagli, Fuat Dïlmec, Halit Akbas
Lung has critic function in gas exchange, supplying oxygen to all cells. Rapid metastasis and the high rate of mortality characterises lung cancer. There are two types of this disease, small cell and non-small cell, which differs from each other according to histopathologic features. To date, many therapeutic approaches have been developed to destroy this deadly type of cancer, which one of them is mRNA targeted therapies through miRNA. miRNAs are 19-25 base paired molecules be able to suppress and destruct mRNA and found to be involved in development and progression of lung cancer...
June 12, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29904909/inactivation-of-tp53-and-pten-drives-rapid-development-of-pleural-and-peritoneal-malignant-mesotheliomas
#15
Eleonora Sementino, Craig W Menges, Yuwaraj Kadariya, Suraj Peri, Jinfei Xu, Zemin Liu, Richard G Wilkes, Kathy Q Cai, Frank J Rauscher, Andres J Klein-Szanto, Joseph R Testa
Malignant mesothelioma (MM) is a therapy-resistant cancer arising primarily from the lining of the pleural and peritoneal cavities. The most frequently altered genes in human MM are cyclin-dependent kinase inhibitor 2A (CDKN2A), which encodes components of the p53 (p14ARF) and RB (p16INK4A) pathways, BRCA1-associated protein 1 (BAP1), and neurofibromatosis 2 (NF2). Furthermore, the p53 gene (TP53) itself is mutated in ~15% of MMs. In many MMs, the PI3K-PTEN-AKT-mTOR signaling node is hyperactivated, which contributes to tumor cell survival and therapeutic resistance...
June 15, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29902286/association-of-somatic-driver-alterations-with-prognosis-in-postmenopausal-hormone-receptor-positive-her2-negative-early-breast-cancer-a-secondary-analysis-of-the-big-1-98-randomized-clinical-trial
#16
Stephen J Luen, Rebecca Asher, Chee Khoon Lee, Peter Savas, Roswitha Kammler, Patrizia Dell'Orto, Olivia Maria Biasi, David Demanse, Lellean JeBailey, Sinead Dolan, Wolfgang Hackl, Beat Thuerlimann, Giuseppe Viale, Marco Colleoni, Meredith M Regan, Sherene Loi
Importance: A range of somatic driver alterations has been described in estrogen receptor-positive, HER2-negative (ER+/HER2-) early breast cancer (BC); however, the clinical relevance is unknown. Objective: To investigate associations of driver alterations with prognosis and the role of PIK3CA mutations in prediction of benefit associated with endocrine therapy in postmenopausal patients with ER+/HER2- early BC treated with tamoxifen or letrozole. Design, Setting, and Participants: The Breast International Group (BIG) 1-98 trial randomized 8010 postmenopausal patients with hormone receptor-positive, operable, invasive BC to monotherapy with letrozole, tamoxifen, or a sequential strategy for 5 years...
June 14, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29902076/quantitative-magnetic-resonance-imaging-and-radiogenomic-biomarkers-for-gliomas-characterisation-a-systematic-review
#17
Pohchoo Seow, Jeannie Hsiu Ding Wong, Azlina Ahmad Annuar, Abhishek Mahajan, Nor Aniza Abdullah, Norlisah Ramli
  The diversity of tumour characteristics among glioma patients, even within same tumour grade, is a big challenge for disease outcome prediction. A possible approach for improved radiological imaging could come from combining information obtained at molecular level. This review assembles recent evidence highlighting the value of using radiogenomic biomarkers to infer underlying biology of gliomas and correlation with imaging features.  Methods:  Literature search was done for articles published between 2002 and 2017 on Medline electronic databases...
June 14, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29901519/evidence-of-a-monoclonal-origin-for-bilateral-serous-tubal-intraepithelial-neoplasia
#18
Emily E Meserve, Kyle C Strickland, Alexander Miron, Thing R Soong, Frank Campbell, Brooke E Howitt, Christopher P Crum
Serous tubal intraepithelial carcinoma (STIC) is found in 10% to 60% of cases of tuboovarian high-grade serous carcinoma (HGSC) and is presumed to be the site of origin, linking many HGSCs to the fallopian tube. Bilateral STIC is present in ∼20% of cases. Because clonal Tp53 mutations are a defining feature of HGSC, including their associated STICs, we analyzed 4 cases of bilateral serous tubal intraepithelial neoplasia (STIN), including STIC and Tp53-mutated serous tubal intraepithelial lesions (STILs), associated with HGSC to determine whether they contained the same or different p53 mutations...
June 12, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29901220/definition-of-disease-progression-risk-stratification-in-untreated-chronic-lymphocytic-leukemia-using-combined-clinical-molecular-and-virological-variables
#19
Shuchao Qin, Lei Fan, Jinhua Liang, Robert Gale, Yi Miao, Yujie Wu, Rong Wang, Hui Yang, Wei Wu, Yi Xia, Jiazhu Wu, Huayuan Zhu, Li Wang, Wei Xu, Jianyong Li
Prognoses of persons with chronic lymphocytic leukemia (CLL) including time-to-therapy (TTT) and survival is heterogeneous. Risk factors and predictive scoring systems are mostly developed in persons of predominately European descent with CLL. Whether these systems accurately predict TTT and survival of Han Chinese with CLL is unknown. We interrogated clinical and laboratory data from 334 newly diagnosed, untreated Chinese CLL without treatment indication upon diagnosis to identify variables associated with TTT and develop a prognostic score...
June 14, 2018: Hematological Oncology
https://www.readbyqxmd.com/read/29901149/diagnostic-value-and-lymph-node-metastasis-prediction-of-a-custom%C3%A2-made-panel-thyroline-in-thyroid-cancer
#20
Zunfu Ke, Yihao Liu, Yunjian Zhang, Jie Li, Ming Kuang, Sui Peng, Jinyu Liang, Shuang Yu, Lei Su, Lili Chen, Cong Sun, Bin Li, Jessica Cao, Weiming Lv, Haipeng Xiao
Differentiation of benign and malignant thyroid nodules is crucial for clinical management. Here, we explored the efficacy of next‑generation sequencing (NGS) in predicting the classification of benign and malignant thyroid nodules and lymph node metastasis status, and simultaneously compared the results with ultrasound (US). Thyroline was designed to detect 15 target gene mutations and 2 fusions in 98 formalin‑fixed, paraffin‑embedded (FFPE) tissues, including those from 82 thyroid cancer (TC) patients and 16 patients with benign nodules...
June 14, 2018: Oncology Reports
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