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Pharmacoeconomics

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https://www.readbyqxmd.com/read/29791482/impact-of-high-versus-low-dose-neuromuscular-blocking-agent-administration-on-unplanned-30-day-readmission-rates-in-retroperitoneal-laparoscopic-surgery
#1
Martijn Boon, Chris Martini, H Keri Yang, Shuvayu S Sen, Rob Bevers, Michiel Warlé, Leon Aarts, Marieke Niesters, Albert Dahan
Recent data shows that a neuromuscular block (NMB) induced by administration of high doses of rocuronium improves surgical conditions in certain procedures. However, there are limited data on the effect such practices on postoperative outcomes. We performed a retrospective analysis to compare unplanned 30-day readmissions in patients that received high-dose versus low-dose rocuronium administration during general anesthesia for laparoscopic retroperitoneal surgery. This retrospective cohort study was performed in the Netherlands in an academic hospital where routine high-dose rocuronium NMB has been practiced since July 2015...
2018: PloS One
https://www.readbyqxmd.com/read/29781758/analysis-of-the-drug-formulary-and-the-purchasing-process-at-a-moroccan-university-medical-center
#2
Z Lachhab, S Serragui, M Hassar, Y Cherrah, A Errougani, S Ahid
AIM: To give an overview of the pharmaceutical policy in the largest medical center in Morocco, a developing country in socio-economic transition. METHODS: This is an analytical descriptive study of the drug formulary and the purchasing process carried out at the Ibn Sina University Medical Center. RESULTS: Our formulary included 830 drugs belonging to 14 classes according to the Anatomical, Therapeutic and Chemical (ATC) Classification System...
May 21, 2018: Expert Review of Pharmacoeconomics & Outcomes Research
https://www.readbyqxmd.com/read/29781353/clinical-trials-with-multiple-endpoints-can-establish-a-correlation-but-not-yet-causality-between-dietary-supplementation-with-omega-3-fatty-acids-and-keratoconjunctivitis-sicca
#3
Roger Lee Mendoza
AIM: We review clinical evidence of therapeutic efficacy and effectiveness of omega-3 fatty acids (omega-3s) in keratoconjunctivitis sicca, colloquially known as dry eye disease. In doing so, we identify relevant literature to address the following questions: 1) What definitive guidance can clinical evidence offer eye physicians and their patients? 2) What aspects of omega-3 supplementation lack definitive evidence, and how might economic assessments help? METHODS: A targeted and systematic search strategy based on PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) was designed in this study for refereed clinical trials of omega-3s in dry eye treatment...
May 21, 2018: Journal of Medical Economics
https://www.readbyqxmd.com/read/29779401/evaluating-quantity-and-quality-of-literature-focusing-on-health-economics-and-pharmacoeconomics-in-gulf-cooperation-council-countries
#4
Islam Eljilany, Faris El-Dahiyat, Louise Elizabeth Curley, Zaheer-Ud-Din Babar
BACKGROUND: The importance of pharmacoeconomics and health economics has been augmented. It has the potential to provide evidence to aid in optimal decision-making in the funding of cost-effective medicines and services in Gulf Cooperation Council countries (G.C.C). OBJECTIVE: To evaluate the quality and quantity of health economic research published until the end of 2017 in G.C.C. METHOD: Studies were included according to inclusion and exclusion criteria...
May 19, 2018: Expert Review of Pharmacoeconomics & Outcomes Research
https://www.readbyqxmd.com/read/29775974/translation-and-cultural-adaptation-of-the-short-form-food-frequency-questionnaire-for-pregnancy-into-brazilian-portuguese
#5
Karina Tamy Kasawara, Daiane S M Paulino, Roberta Bgeginski, Chistine L Cleghorn, Michelle F Mottola, Fernanda Garanhani Surita
OBJECTIVE:  To translate and culturally adapt the short-form Food Frequency Questionnaire (SFFFQ) for pregnant women, which contains 24 questions, into Brazilian Portuguese. METHODS:  Description of the process of translation and cultural adaptation of the SFFFQ into Brazilian Portuguese. The present study followed the recommendation of the International Society for Pharmacoeconomics and Outcomes Research for translation and cultural adaptation with the following steps: 1) preparation; 2) first translation; 3) reconciliation; 4) back translation; 5) revision of back translation; 6) harmonization; 7) cognitive debriefing; 8) revision of debriefing results; 9) syntax and orthographic revision; and 10) final report...
May 18, 2018: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/29768712/innovation-at-the-intersection-of-clinical-trials-and-real-world-data-science-to-advance-patient-care
#6
REVIEW
Brandon Swift, Lokesh Jain, Craig White, Vasu Chandrasekaran, Aman Bhandari, Dyfrig A Hughes, Pravin R Jadhav
While efficacy and safety data collected from randomized clinical trials are the evidentiary standard for determining market authorization, this alone may no longer be sufficient to address the needs of key stakeholders (regulators, providers, and payers) and guarantee long-term success of pharmaceutical products. There is a heightened interest from stakeholders on understanding the use of real-world evidence (RWE) to substantiate benefit-risk assessment and support the value of a new drug. This review provides an overview of real-world data (RWD) and related advances in the regulatory framework, and discusses their impact on clinical research and development...
May 16, 2018: Clinical and Translational Science
https://www.readbyqxmd.com/read/29766439/translation-and-cross-cultural-adaptation-of-eight-pediatric-promis%C3%A2-item-banks-into-spanish-and-german
#7
J Devine, F Klasen, J Moon, M Herdman, M P Hurtado, G Castillo, A C Haller, H Correia, C B Forrest, U Ravens-Sieberer
PURPOSE: The Patient-Reported Outcome Measurement Information System (PROMIS®) is a National Institutes of Health (NIH)-funded initiative to develop reliable, valid, and normed item banks to measure health. We describe the first large-scale translation and cross-cultural adaptation effort to German and Spanish of eight pediatric PROMIS item banks: Physical activity (PAC), subjective well-being (SWB), experiences of stress (EOS), and family relations (FAM). METHODS: We utilized methods outlined in the International Society for Pharmacoeconomics and Outcomes Research (ISPOR) PRO Translation Task Force recommendations...
May 15, 2018: Quality of Life Research
https://www.readbyqxmd.com/read/29753344/challenges-in-research-and-health-technology-assessment-of-rare-disease-technologies-report-of-the-ispor-rare-disease-special-interest-group
#8
Sandra Nestler-Parr, Daria Korchagina, Mondher Toumi, Chris L Pashos, Christopher Blanchette, Elizabeth Molsen, Thomas Morel, Steven Simoens, Zoltán Kaló, Ruediger Gatermann, William Redekop
BACKGROUND: Successful development of new treatments for rare diseases (RDs) and their sustainable patient access require overcoming a series of challenges related to research and health technology assessment (HTA). These impediments, which may be unique to RDs or also apply to common diseases but are particularly pertinent in RDs, are diverse and interrelated. OBJECTIVE: To develop for the first time a catalog of primary impediments to RD research and HTA, and to describe the cause and effect of individual challenges...
May 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29737290/pharmacoeconomic-evaluation-of-glimepiride-combined-with-other-drugs-in-the-treatment-of-diabetes
#9
Xiufang Liu, Liping Zeng, Wenchao Xu
The goal of diabetic drug treatment is to stabilize the blood sugar for a long time to close to the normal level, to correct the metabolic disorder and eliminate the symptoms. At present, glimepiride has become commonly used drugs for the treatment of diabetes with obesity. Compared with metformin, acarbose and rosiglitazone, glimepiride has different mechanisms of drug action, clinical combination showed synergistic hypoglycemic effect, good clinical curative effect. So, we use three treatments to study as group A (glimepiride and metformin); group B (glimepiride and acarbose); Group C (glimepiride and rosiglitazone)...
May 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29735458/pharmacoeconomic-evaluation-of-glimepiride-combined-with-other-drugs-in-the-treatment-of-diabetes
#10
Xiufang Liu, Liping Zeng, Wenchao Xu
The goal of diabetic drug treatment is to stabilize the blood sugar for a long time to close to the normal level, to correct the metabolic disorder and eliminate the symptoms. At present, glimepiride has become commonly used drugs for the treatment of diabetes with obesity. Compared with metformin, acarbose and rosiglitazone, glimepiride has different mechanisms of drug action, clinical combination showed synergistic hypoglycemic effect, good clinical curative effect. So, we use three treatments to study as group A (glimepiride and metformin); group B (glimepiride and acarbose); Group C (glimepiride and rosiglitazone)...
May 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29729645/health-technology-assessment-and-its-use-in-drug-policies-in-china
#11
Xuemei Zhen, Xueshan Sun, Hengjin Dong
OBJECTIVE: To review drug policies, health technology assessment (HTA), and HTA's use in drug policies in China, to further improve the quality and efficiency of drugs. METHODS: This study draws on multiple methods. A systematic review of the literature, review of Chinese government documents and statistical handbooks, and authors' experiences in drug policies and HTA in China were combined to achieve the objective. RESULTS: Of 571 studies identified in the initial search, 14 eligible articles (6 English, 8 Chinese) were finally included...
May 2, 2018: Value in Health Regional Issues
https://www.readbyqxmd.com/read/29720917/comparison-of-the-pharmacoeconomics-of-calfactant-and-poractant-alfa-in-surfactant-replacement-erapy
#12
Michael M Zayek, Fabien G Eyal, Robert C Smith
OBJECTIVE: To compare the pharmacy costs of calfactant (Infasurf, ONY, Inc.) and poractant alfa (Curosurf, Chiesi USA, Inc., Cary, NC). METHODS: The University of South Alabama Children's and Women's Hospital switched from calfactant to poractant alfa in 2013 and back to calfactant in 2015. Retrospectively, we used deidentified data from pharmacy records that provided type of surfactant administered, gestational age, birth weight, and number of doses on each patient...
March 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/29704659/new-drug-reimbursement-and-pricing-policy-in-taiwan
#13
Gau-Tzu Chen, Shu-Chen Chang, Chee-Jen Chang
BACKGROUND: Taiwan has implemented a national health insurance system for more than 20 years now. The benefits of pharmaceutical products and new drug reimbursement scheme are determined by the Expert Advisory Meeting and the Pharmaceutical Benefit and Reimbursement Scheme (PBRS) Joint Committee in Taiwan. OBJECTIVES: To depict the pharmaceutical benefits and reimbursement scheme for new drugs and the role of health technology assessment (HTA) in drug policy in Taiwan...
April 25, 2018: Value in Health Regional Issues
https://www.readbyqxmd.com/read/29694293/development-of-a-pharmacoeconomic-model-to-demonstrate-the-effect-of-clinical-pharmacist-involvement-in-diabetes-management
#14
Heather Ourth, Jordan Nelson, Patrick Spoutz, Anthony P Morreale
BACKGROUND: A data collection tool was developed and nationally deployed to clinical pharmacists (CPs) working in advanced practice provider roles within the Department of Veterans Affairs to document interventions and associated clinical outcomes. Intervention and short-term clinical outcome data derived from the tool were used to populate a validated clinical outcomes modeling program to predict long-term clinical and economic effects. OBJECTIVE: To predict the long-term effect of CP-provided pharmacotherapy management on outcomes and costs for patients with type 2 diabetes...
May 2018: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29652304/-approach-for-identifying-of-treatment-option-for-pediatric-patients-in-guillain-barre-syndrome-considering-results-of-pharmacoeconomic-analysis
#15
A K Shakaryan, A V Rakhteenko, R I Yagudina, A Yu Kulikov, V G Serpik, I V Mitrofanova
AIM: A pharmacoeconomic analysis of direct costs on treatment with high dose intravenous immunoglobulins (IVIG) and plasmapheresis (PP) in children. MATERIAL AND METHODS: Literature data on the pathogenesis of Guillain-Barre syndrome (GBS) were analyzed. The results of pharmacoeconomic analysis of direct costs on treatment of GBS using IVIG and PP are presented. Risks for complications during treatment with IVIG and PP are calculated. RESULTS AND CONCLUSION: The pharmacoeconomic analysis demonstrates comparable costs of treatment with IVIG or PP in the Russian Federation...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29651649/systematic-review-of-the-economic-burden-of-overt-hepatic-encephalopathy-and-pharmacoeconomic-impact-of-rifaximin
#16
REVIEW
Guy Neff, Woodie Zachry Iii
BACKGROUND: Hepatic encephalopathy (HE), a common neurologic complication in cirrhosis, is associated with substantial disease and economic burden. Rifaximin is a non-systemic antibiotic that reduces the risk of overt HE recurrence and overt HE-related hospitalizations. OBJECTIVE: Our objective was to provide an overview of the direct HE-related costs and cost benefits of rifaximin, lactulose, and rifaximin plus lactulose. METHODS: A systematic review of PubMed and relevant meeting abstracts was conducted to identify publications since 1 January 2007 reporting economic data related to HE and rifaximin and/or lactulose...
April 12, 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/29618422/pharmacoeconomic-analysis-of-treatment-of-patients-infected-with-hepatitis-c-virus
#17
Sadia Qureshi, M H Qazi, Muhammad Tahir Aziz
Hepatitis C infection imposes a high economic burden globally. It has been estimated that in 2012, the healthcare cost of Hepatitis C virus (HCV) was $6.5 billion. Furthermore, it has been projected that the cost will reach at $9.1 billion by the year 2024.Frequency of hepatitis C in Pakistan is significantly higher (4.5%) when compared to the populations like India (0.7%), Nepal (1.0), Myanmar (2.5%), Iran (0.8%), China (1%) and Afghanistan (1.1%). The current standard of care for chronic infection with hepatitis C virus is 24 or 48 weeks of therapy with Pegylated interferon-alfa-2a (Peg INF) +Ribavirin (RV) or Interferon alfa-2a (INF) + RV...
March 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29607414/pharmacoeconomics-of-three-therapeutic-schemes-for-anti-tuberculosis-therapy-induced-liver-injury-in-china
#18
Yu Chen, Peng Ye, Chongwu Ren, Pengfei Ren, Zheng Ma, Lin Zhang, Wenliang Zhou, Changjie Jiang
To evaluate the pharmacoeconomics of three therapeutic schemes in treating anti-tuberluosis therapy -induced liver injury (anti-TB DILI). Methods: In the construction of a decision tree model, the efficacy and safety parameters came from the results of the randomized, controlled trial conducted here, the effect parameters were derived from expert advice, and the cost parameters, such as usage specification, number, and unit price, came from literature, expert advice, and so on. Results: The cost-effectiveness analysis (CEA) based on the effect degrees showed that bicyclol had the best effect (4...
2018: Open Medicine (Warsaw, Poland)
https://www.readbyqxmd.com/read/29605496/cost-effectiveness-of-posaconazole-in-private-and-public-brazilian-hospitals
#19
Felipe F B Tuon, Khaiany Lino Florencio, Clóvis Arns da Cunha, Jaime Luis Lopes Rocha
BACKGROUND: Posaconazole is used for the prophylaxis of invasive fungal disease (IFD). Previous studies have shown it to be cost-effective compared to fluconazole/itraconazole. However, posaconazole has never been economically evaluated in developing countries. AIMS: The aim of the present study was to perform a cost-effectiveness analysis of posaconazole compared to fluconazole in public (SUS) and private hospitals (PHS) in Brazil. METHODS: A cost-effectiveness simulation was conducted on the basis of a pivotal study on the use of posaconazole in acute myeloid leukemia (AML) patients, adjusting the costs to Brazilian data...
March 28, 2018: Revista Iberoamericana de Micología
https://www.readbyqxmd.com/read/29602163/portuguese-recommendations-for-the-prevention-diagnosis-and-management-of-primary-osteoporosis-2018-update
#20
A M Rodrigues, H Canhão, A Marques, C Ambrósio, J Borges, P Coelho, L Costa, S Fernandes, I Gonçalves, M Gonçalves, M Guerra, M L Marques, S Pimenta, P Pinto, G Sequeira, E Simões, L Teixeira, C Vaz, E Vieira-Sousa, R Vieira, F Alvarenga, F Araújo, A Barcelos, F Barcelos, R Barros, M Bernardes, J Canas da Silva, A Cordeiro, M Costa, L Cunha-Miranda, M Cruz, A C Duarte, C Duarte, A Faustino, G Figueiredo, J E Fonseca, C Furtado, J Gomes, C Lopes, A F Mourão, M Oliveira, F M Pimentel-Santos, A Ribeiro, T Sampaio da Nóvoa, M Santiago, C Silva, A Silva-Dinis, S Sousa, J Tavares-Costa, G Terroso, A Vilar, J C Branco, V Tavares, J C Romeu, Jap da Silva
BACKGROUND: Advances in osteoporosis (OP)case definition, treatment options, optimal therapy duration and pharmacoeconomic evidence in the national context motivated the Portuguese Society of Rheumatology (SPR) to update the Portuguese recommendations for the diagnosis and management of osteoporosis published in 2007. METHODS: SPR bone diseases' working group organized meetings involving 55 participants (rheumatologists, rheumatology fellows and one OP specialist nurse) to debate and develop the document...
January 2018: Acta Reumatológica Portuguesa
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