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Cost-utility

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https://www.readbyqxmd.com/read/28635368/efficacy-and-safety-of-autologous-cell-therapies-for-knee-cartilage-defects-autologous-stem-cells-chondrocytes-or-the-two-randomized-controlled-trial-design
#1
James B Richardson, Karina T Wright, Johanna Wales, Jan Herman Kuiper, Helen S McCarthy, Peter Gallacher, Paul E Harrison, Sally Roberts
AIM: The main aim of this trial is to test the safety and efficacy of autologous stromal/stem cells, chondrocytes or the two combined in the treatment of knee cartilage defects. PATIENTS & METHODS: Patients with symptomatic chondral/osteochondral defects will be randomized to cell therapy treatment with one of three cell populations (1:1:1). The primary efficacy outcome is a functional knee score (Lysholm) at 15 months post-treatment and the primary safety outcome is the incidence of adverse events...
June 21, 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/28633983/corrigendum-to-cost-utility-of-video-electroencephalography-monitoring-followed-by-surgery-in-adults-with-drug-resistant-focal-epilepsy-in-thailand-world-neurosurgery-98-2017-750-760
#2
Pimprapa Kitwitee, Kanjana Unnwongse, Teeradej Srikijvilaikul, Tinonkorn Yadee, Chulaporn Limwattananon
No abstract text is available yet for this article.
June 17, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28623434/-cost-analysis-as-a%C3%A2-tool-for-assessing-the-efficacy-of-intensive-care-units
#3
T Maierhofer, F Pfisterer, A Bender, H Küchenhoff, O Moerer, H Burchardi, W H Hartl
BACKGROUND: The German "Hospital Structure Act" intends to align the state hospital planning on quality criteria. Within this process cost-utility analyses (CUAs) shall be used to assess the efficacy of medical care. To be objective, CUAs of intensive care units (ICUs) require standardization (adjustment) of costs. The present study analyzed the extent to which treatment costs are related to patient-specific baseline variables (such as type and severity of the primary disease). METHODS: From 2000-2004, a bottom-up procedure was used to quantify total costs on 14 ICUs in nine German university hospitals...
June 16, 2017: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/28621643/the-clinical-effectiveness-of-different-surveillance-strategies-to-prevent-colorectal-cancer-in-people-with-intermediate-grade-colorectal-adenomas-a-retrospective-cohort-analysis-and-psychological-and-economic-evaluations
#4
Wendy Atkin, Amy Brenner, Jessica Martin, Katherine Wooldrage, Urvi Shah, Fiona Lucas, Paul Greliak, Kevin Pack, Ines Kralj-Hans, Ann Thomson, Sajith Perera, Jill Wood, Anne Miles, Jane Wardle, Benjamin Kearns, Paul Tappenden, Jonathan Myles, Andrew Veitch, Stephen W Duffy
BACKGROUND: The UK guideline recommends 3-yearly surveillance for patients with intermediate-risk (IR) adenomas. No study has examined whether or not this group has heterogeneity in surveillance needs. OBJECTIVES: To examine the effect of surveillance on colorectal cancer (CRC) incidence; assess heterogeneity in risk; and identify the optimum frequency of surveillance, the psychological impact of surveillance, and the cost-effectiveness of alternative follow-up strategies...
April 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28619778/in-patients-with-severe-uncontrolled-asthma-does-knowledge-of-adherence-and-inhaler-technique-using-electronic-monitoring-improve-clinical-decision-making-a-protocol-for-a-randomised-controlled-trial
#5
Matshediso C Mokoka, Lorna Lombard, Elaine M MacHale, Joanne Walsh, Breda Cushen, Imran Sulaiman, Damien Mc Carthy, Fiona Boland, Frank Doyle, Eoin Hunt, Desmond M Murphy, John Faul, Marcus Butler, Kathy Hetherington, J Mark FitzGerald, Job Fm van Boven, Liam G Heaney, Richard B Reilly, Richard W Costello
INTRODUCTION: Many patients with asthma remain poorly controlled despite the use of inhaled corticosteroids and long-acting beta agonists. Poor control may arise from inadequate adherence, incorrect inhaler technique or because the condition is refractory. Without having an objective assessment of adherence, clinicians may inadvertently add extra medication instead of addressing adherence. This study aims to assess if incorporating objectively recorded adherence from the Inhaler Compliance Assessment (INCA) device and lung function into clinical decision making provides more cost-effective prescribing and improves outcomes...
June 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/28606254/-internal-fixation-and-hemiarthroplasty-for-the-treatment-of-displaced-femoral-neck-fracture-a-cost-utility-analysis
#6
B Xu, Q Wang, H Jin, J X Li, H N Liu, Y J Mao, J Wei
Objective: To compare the cannulated screw internal fixation (IF) and hemiarthroplasty (HA) for displaced femoral neck fracture with cost-utility analysis (CUA). Methods: From January 2014 to August 2015, a total of 87 patients above 60 years old with displaced femoral neck fracture were admitted into the study and divided into 2 groups according to surgery type. There were 41 cases in IF group and 46 cases in HA group. During 1 year follow-up we collected the total cost due to fracture and applied EQ-5D index to evaluate the clinical effects...
June 6, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28602382/value-in-oral-and-maxillofacial-surgery-a-systematic-review-of-economic-analyses
#7
Benjamin Geisler, Yisi D Ji, Zachary S Peacock
PURPOSE: The purpose of this study is to describe the state of economic analyses in the field of oral and maxillofacial surgery (OMS). MATERIALS AND METHODS: A systematic search of published literature up to 2016 was performed. The inclusion criteria were as follows: English-language articles on economic analyses pertaining to OMS including anesthesia and pain management; dentoalveolar surgery; orthognathic, cleft, and/or obstructive sleep apnea treatment; pathology; reconstruction; temporomandibular disorders; trauma; and other...
May 18, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28601866/cost-utility-analysis-of-bariatric-surgery-in-italy-results-of-decision-analytic-modelling
#8
Marcello Lucchese, Oleg Borisenko, Lorenzo Giovanni Mantovani, Paolo Angelo Cortesi, Giancarlo Cesana, Daniel Adam, Elisabeth Burdukova, Vasily Lukyanov, Nicola Di Lorenzo
OBJECTIVE: To evaluate the cost-effectiveness of bariatric surgery in Italy from a third-party payer perspective over a medium-term (10 years) and a long-term (lifetime) horizon. METHODS: A state-transition Markov model was developed, in which patients may experience surgery, post-surgery complications, diabetes mellitus type 2, cardiovascular diseases or die. Transition probabilities, costs, and utilities were obtained from the Italian and international literature...
June 10, 2017: Obesity Facts
https://www.readbyqxmd.com/read/28597489/development-of-a-web-based-application-and-multicountry-analysis-framework-for-assessing-interdicted-infections-and-cost-utility-of-screening-donated-blood-for-hiv-hcv-and-hbv
#9
B Custer, M P Janssen, G Hubben, M Vermeulen, M van Hulst
BACKGROUND AND OBJECTIVES: Most countries test donations for HIV, HCV and HBV using serology with or without nucleic acid testing (NAT). Cost-utility analyses provide information on the relative value of different screening options. The aim of this project was to develop an open access risk assessment and cost-utility analysis web-tool for assessing HIV, HCV and HBV screening options (http://www.isbtweb.org/working-parties/transfusion-transmitted-infectious-diseases/). An analysis for six countries (Brazil, Ghana, the Netherlands, South Africa, Thailand and USA) was conducted...
June 8, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28593532/establishing-benchmark-eq-5d-3l-population-health-state-utilities-and-identifying-their-correlates-in-gansu-province-china
#10
Lei Si, Lei Shi, Mingsheng Chen, Andrew J Palmer
PURPOSES: Despite a flurry of cost utility analyses conducted in the Chinese population in recent years, a standard set of health state utilities (HSUs) for the Chinese population is lacking. The aims of this study were to (1) determine benchmark age- and sex-specific HSUs for a Chinese population, and (2) assess key correlates of HSUs in this population. METHODS: Quality-of-life was evaluated using the validated EQ-5D-3L questionnaire. HSUs were calculated using data collected from Gansu Province (n = 9833)...
June 7, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28592927/cost-utility-of-burns-management-in-nigeria-a-case-study-of-the-national-orthopaedic-hospital-enugu
#11
C E Okafor, O Onunka, L N Idoko
A major problem of burns is the high cost of management, as well as the discrimination and disability they can cause to patients. Maximising resource utilisation is of key importance for lower-middle-income countries (LMICs) like Nigeria. There is a need to know if Nigerian patients who were victims of burns get the best value for money. This study aimed to evaluate the average cost of managing burns in Nigeria, and determine if the treatment approach is cost-effective. The study was a cost-utility analysis from the perspective of health service providers in Nigeria, a case study of the National Orthopaedic Hospital Enugu (NOHE) using 2013 Microsoft excel...
March 31, 2017: Annals of Burns and Fire Disasters
https://www.readbyqxmd.com/read/28587529/colonoscopic-surveillance-a-cost-effective-method-to-prevent-hereditary-and-familial-colorectal-cancer
#12
Olle Sjöström, Lars Lindholm, Beatrice Melin
OBJECTIVE: Approximately 20-30% of all colorectal cancer (CRC) cases may have a familial contribution. The family history of CRC can be prominent (e.g., hereditary colorectal cancer (HCRC)) or more moderate (e.g., familial colorectal cancer (FCRC)). For family members at risk, colonoscopic surveillance is a well-established method to prevent both HCRC and FCRC, although the evidence for the exact procedures of the surveillance is limited. Surveillance can come at a high price if individuals are frequently examined, as this may result in unnecessary colonoscopies in relation to actual risk for CRC...
June 6, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28578712/pharmacoeconomic-studies-in-world-health-organization-eastern-mediterranean-countries-reporting-completeness
#13
Qais Alefan, Karen Rascati
OBJECTIVES: The aim of this study was to evaluate the extent of reporting necessary information in published health economic research in World Health Organization Eastern Mediterranean Countries (WHO EMC). METHODS: A systematic literature search was conducted using PubMed and Google Scholar to identify pharmacoeconomic studies conducted in WHO EMC. The inclusion criteria for the studies were: (i) original studies, (ii) compared pharmaceutical services or drugs, (iii) conducted in WHO EMC, (iv) manuscript published in English...
June 5, 2017: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/28577700/value-for-money-in-h1n1-influenza-a-systematic-review-of-the-cost-effectiveness-of-pandemic-interventions
#14
REVIEW
Hélène Pasquini-Descomps, Nathalie Brender, David Maradan
BACKGROUND: The 2009 A/H1N1 influenza pandemic generated additional data and triggered new studies that opened debate over the optimal strategy for handling a pandemic. The lessons-learned documents from the World Health Organization show the need for a cost estimation of the pandemic response during the risk-assessment phase. Several years after the crisis, what conclusions can we draw from this field of research? OBJECTIVE: The main objective of this article was to provide an analysis of the studies that present cost-effectiveness or cost-benefit analyses for A/H1N1 pandemic interventions since 2009 and to identify which measures seem most cost-effective...
June 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28577543/implementation-of-emental-health-care-viewpoints-from-key-informants-from-organizations-and-agencies-with-ehealth-mandates
#15
Lori Wozney, Amanda S Newton, Nicole D Gehring, Kathryn Bennett, Anna Huguet, Lisa Hartling, Michele P Dyson, Patrick McGrath
BACKGROUND: The use of technology such as computers, tablets, and smartphones to improve access to and the delivery of mental health care (eMental Health care) is growing worldwide. However, despite the rapidly expanding evidence base demonstrating the efficacy of eMental Health care, its implementation in clinical practice and health care systems remains fragmented. To date, no peer-reviewed, key-informant studies have reported on the perspectives of decision-makers concerned with whether and how to implement eMental Health care...
June 2, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28574985/economic-evaluation-of-multidisciplinary-rehabilitation-treatment-versus-cognitive-behavioural-therapy-for-patients-with-chronic-fatigue-syndrome-a-randomized-controlled-trial
#16
Desirée Vos-Vromans, Silvia Evers, Ivan Huijnen, Albère Köke, Minou Hitters, Nieke Rijnders, Menno Pont, André Knottnerus, Rob Smeets
BACKGROUND: A multi-centre RCT has shown that multidisciplinary rehabilitation treatment (MRT) is more effective in reducing fatigue over the long-term in comparison with cognitive behavioural therapy (CBT) for patients with chronic fatigue syndrome (CFS), but evidence on its cost-effectiveness is lacking. AIM: To compare the cost-effectiveness of MRT versus CBT for patients with CFS from a societal perspective. METHODS: A multi-centre randomized controlled trial comparing MRT with CBT was conducted among 122 patients with CFS diagnosed using the 1994 criteria of the Centers for Disease Control and Prevention and aged between 18 and 60 years...
2017: PloS One
https://www.readbyqxmd.com/read/28560939/a-new-health-technology-assessment-system-for-japan-simulating-the-potential-impact-on-the-price-of-simeprevir
#17
Jörg Mahlich, Isao Kamae, Bruno Rossi
OBJECTIVES: Japanese authorities have announced a plan to introduce a health technology assessment (HTA) system in 2016. This study assessed the potential impact of such a policy on the price of the antivirologic drug simeprevir. METHODS: Taking the antivirologic drug simeprevir as an example, we compared the current Japanese price with hypothetical prices that might result if a U.K. (cost-utility) or German (efficiency frontier) style HTA assessment was in place...
May 31, 2017: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/28558703/-fibromyalgia-and-quality-of-life-mapping-the-revised-fibromyalgia-impact-questionnaire-to-the-preference-based-instruments
#18
Daniel Collado-Mateo, Gang Chen, Miguel A Garcia-Gordillo, Angelo Iezzi, José C Adsuar, Pedro R Olivares, Narcis Gusi
BACKGROUND: The revised version of the Fibromyalgia Impact Questionnaire (FIQR) is one of the most widely used specific questionnaires in FM studies. However, this questionnaire does not allow calculation of QALYs as it is not a preference-based measure. The aim of this study was to develop mapping algorithm which enable FIQR scores to be transformed into utility scores that can be used in the cost utility analyses. METHODS: A cross-sectional survey was conducted...
May 30, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28538287/cost-utility-analysis-of-reconstruction-compared-with-primary-amputation-for-patients-with-severe-lower-limb-trauma-in-colombia
#19
Mateo Ceballos, Carlos Oliver Valderrama, Luis Esteban Orozco, Laura Sánchez, Juan Pablo Valderrama, Luz Helena Lugo
BACKGROUND: To establish, from the health system perspective, the cost-utility relationship of limb reconstruction compared with primary amputation for patients over 32 years with grade IIIB and IIIC severe lower limb trauma in Colombia, S.A. METHODS: A Markov model was built including different short-term and long-term states that represent the main events that a patient could experience after a lower limb amputation or a reconstruction. A 42-year time horizon was considered for the base case...
May 17, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28535546/cost-utility-analysis-of-lumbar-interlaminar-epidural-injections-in-the-treatment-of-lumbar-disc-herniation-central-spinal-stenosis-and-axial-or-discogenic-low-back-pain
#20
Laxmaiah Manchikanti, Vidyasagar Pampati, Ramsin M Benyamin, Joshua A Hirsch
BACKGROUND: Cost utility or cost effective analysis continues to take center stage in the United States for defining and measuring the value of treatments in interventional pain management. Appropriate cost utility analysis has been performed for caudal epidural injections, percutaneous adhesiolysis, and spinal cord stimulation. However, the literature pertaining to lumbar interlaminar epidural injections is lacking, specifically in reference to cost utility analysis derived from randomized controlled trials (RCTs) with a pragmatic approach in a practical setting...
May 2017: Pain Physician
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