Francesco Ditonno, Alessandro Veccia, Francesca Montanaro, Greta Pettenuzzo, Antonio Franco, Celeste Manfredi, Luca Triggiani, Cosimo De Nunzio, Marco De Sio, Mariangela Cerruto, Simone Crivellaro, Alexander Kutikov, Riccardo Autorino, Alessandro Antonelli
OBJECTIVE: To perform a systematic review and meta-analysis of trials comparing trimodal therapy (TMT) and radical cystectomy (RC), evaluating differences in terms of oncological outcomes, quality of life, and costs. MATERIALS AND METHODS: In July 2023, a literature search of multiple databases was conducted to identify studies analysing patients with cT2-4 N any M0 muscle-invasive bladder cancer (MIBC; Patients) receiving TMT (Intervention) compared to RC (Comparison), to evaluate survival outcomes, recurrence rates, costs, and quality of life (Outcomes)...
April 15, 2024: BJU International