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Małgorzata Jurys, Sebastian Sirek, Aureliusz Kolonko, Dorota Pojda-Wilczek
Chronic renal failure is associated with many neurological complications. Due to accumulation of uremic neurotoxins axonal degeneration with its secondary demyelination occurs, which results in development of polineuropathy in 60‑100% of patients with chronic renal failure. One of the most severe peripheral neuropathy is optic neuropathy. It is associated with visual deterioration and reduction in quality of life. Symptoms of the optic neuropathy may appear either before or after dialysis therapy. They often worsen after renal transplant, probably due to immunosuppressive regimen...
January 22, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
Federico A Filippín, Alejandra Alfonso, Héctor López-Presas
INTRODUCTION: The celiac disease is an autoimmune bowel disease trigger by gliadine proteins, that can has systemic involvement with varied neurological manifestation since polineuropathy, ataxia, epilepsy, migraine to encephalitis. The aim of the current work is to report a case of possible refractory encephalitis due to celiac disease. CASE REPORT: A 45 years-old man with histopathologic diagnosis of celiac disease but negative celiac antibodies developed encephalic, brainstem and periphery nervous system manifestations: cognitive declaim and seizures, diplopia and ataxia, polyneuropathy and polyradiculopathy respectively; inflammatory cebrospinal fluid and cortico-subcortical and multiple brainstem lesions with mild contrast enhancement; the neurologic deficits progress in spite of gluten a free diet and immuno-suppressive treatment...
April 1, 2016: Revista de Neurologia
Magdalena Rogalska-Płońska, Tadeusz Wojciech Lapinski, Anna Grzeszczuk, Anna Parfieniuk-Kowerda, Robert Flisiak
Cryoglobulinemic syndrome refers to a systemic inflammatory process that involves small and medium-sized vessels accompanied by multi-organ damage. The aim of the present study was to determine the incidence of cryoglobulinemia among patients infected with human immunodeficiency virus (HIV), hepatitis C virus (HCV) and HCV/HIV co-infection, as well as evaluation of cryoglobulinemia type. The association was evaluated between cryoglobulinemia and clinical symptoms, selected biochemical measures of liver and kidney function, virologic measures, as well as histopathological changes in the liver...
April 2015: Viral Immunology
Mariella Valenzise, Luca Alessi, Enrico Bruno, Valeria Cama, Daria Costanzo, Cristina Genovese, Cristina Mignosa, Veronica Scuderi, Filippo DE Luca
Autoimmune polyendocrinopathy-candidiasis-ectodermal-distrophy (APECED) is a rare autosomal recessive disease, which is mainly characterized by the association of many autoimmune diseases, with a classic triad including chronic mucocutaneous candidiasis, hypoparathyroidism and adrenocortical failure. Its clinical spectrum has significantly enlarged in the last years and other non-classic components have been recently described. Aim of this review was to alert pediatricians to these novel clinical aspects of this syndrome, that have been recently included among the autoimmune APECED manifestations: a) chronic lung disease, that may evolve to cor pulmonale and terminal respiratory failure; b) chronic inflammatory demyelinating polineuropathy, with progressive muscular weakness of both arms and legs and sensory loss; c) gastrointestinal dysfunction, with recurrent diarrhea, malabsorption and steatorrhea or chronic constipation...
June 2016: Minerva Pediatrica
Mine Hayriye Sorgun, Seyda Erdogan, Meltem Bay, Erol Ayyıldız, Nezih Yücemen, Osman Iihan, Canan Yücesan
Therapeutic plasma exchange (TPE) is a procedure that reduces amount of circulating antibodies in patients through filtration for the treatment of neurologic diseases in which autoimmunity plays a major role. We reviewed the medical records of 92 neurologic patients who had been consecutively treated by TPE between June 2000 and April 2011 at Ankara University School of Medicine, Neurology Department and The Apaheresis Center. Neurological indications included myastehia gravis (MG, 16 patients), Guillain-Barre syndrome (GBS, 37 patients) and miscellaneous diseases (39 patients)...
October 2013: Transfusion and Apheresis Science
A C Ferreira, F Carvalho, F Nolasco
Familial amyloidotic polineuropathy is a genetic disorder, leading to systemic amyloid deposits, manifested as sensory-motor and autonomic neuropathy. In the Portuguese classical form, the disease is evident at a young age, and causes death if no specific treatment is received. Variability in penetrance, age of onset and clinical course has been published; environmental and genetic factors are believed to contribute to this variability. The authors report a case of a 51-year-old white female, with a medical history of acquired angioedema, late-onset familial amyloidotic polineuropathy and systemic lupus erythemathosus...
November 2012: Lupus
Senija Rašić, Jasminka Džemidžić, Zinaida Karasalihović, Vedad Herenda, Damir Rebić
We present the case of a 67-year-old female patient with microscopic polyangiitis presented with polyneuropathy of lower extremities and rapidly progressive glomerulonephritis. Disease had started as a pain and weakening of muscular strength first in the left and than in the right leg. Electromiography has shown that a mainly dominant neurological affection was paresis of peroneal nerve in both lower extremities. In laboratory examination the titer of anti-myeloperoxidase anti-neutrophilic cytoplasmic antibodies (p-ANCA) was elevated...
February 2012: Bosnian Journal of Basic Medical Sciences
Joanna M Zajkowska, Piotr Owłasiuk, Sławomir A Pancewicz, Renata Swierzbińska, Maciej Kondrusik, Sambor Grygorczuk, Anna Moniuszko, Piotr Czupryna
UNLABELLED: THE AIM of the study was the evaluation of autoantibody reaction against endogenous gangliosides in the course of Lyme borreliosis. MATERIAL AND METHODS: Antibodies against profile of gangliosides composed of GM1, GM2, GM3, GD1a,GD1b,GT1b, GQ1b were evaluated in serum patients with early disseminated (neuroborreliosis) Lyme disease (n = 16), patients with long lasting serologic response against Borrelia burgdorferi (n = 32) and in healthy subjects (n = 16)...
February 2010: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
L Gabaldón Torres, J Salas Felipe, J Fernández Domínguez, F Vivancos Matellanos, E Izal, Fj Arpa Gutiérrez
INTRODUCTION: Restless legs syndrome (RLS) is a chronic neurological disorder that has a negtive influence on sleep. We describe clinical spectrum, polysomnogram and impact on sleep of patients' series with RLS. METHODS: We studied 49 patients with RLS. We analyse socio- demographic information, clinical features, therapy and impact on sleep. We realized differents questionnaire: Index of Severity of Sleep, Epworth Scale, Index-RLS, Questionnaire Quality of Life-RLS and Questionnaire from limitation of laboral productivity...
May 2009: Neurología: Publicación Oficial de la Sociedad Española de Neurología
Múcio Paranhos de Abreu, Carla Cristina Silva Freire, Rogério Shiuguetoshi Miura
BACKGROUND AND OBJECTIVES: Glucose 6-phosphate dehydrogenase (G6PD) deficiency is a relatively common enzymopathy, but there are few publications relating such condition to anesthesia. This report aimed at presenting a case of a G6PD-deficient patient, submitted to Achilles tendon tenotomy under intravenous anesthesia associated to spinal block. CASE REPORT: Male patient, 9 years old, 48 kg, with G6PD deficiency and peripheral polineuropathy, submitted to Achilles tendon tenotomy under general intravenous anesthesia with midazolam, propofol and fentanyl, associated to spinal block with 0...
November 2002: Revista Brasileira de Anestesiologia
José Luciano Braun Filho, Leandro Mamede Braun
BACKGROUND AND OBJECTIVES: Painful polyneuropathy after chemotherapy is often refractory to conservative clinical treatment. The objective of this report was to demonstrate that spinal cord stimulation is an alternative to conventional methods used in the treatment of patients with pain that is difficult to control. CASE REPORT: A 72 year old patient with painful polyneuropathy after chemotherapy approximately 10 years ago, presented severe, continuous, daily pain (visual analog scale = 10) in the lower limbs despite the use of several drugs specific for neuropathic pain...
October 2007: Revista Brasileira de Anestesiologia
Tomasz Hawro, Andrzej Bogucki, Anna Sysa-Jedrzejowska, Jarosław Bogaczewicz, Anna Woźniacka
UNLABELLED: Central nervous system involvement in systemic lupus erythematosus contributes to more serious course and poor prognosis. Whereas neuropsychiatric lupus is the scantiest recognized aspect of SLE. AIM OF THE STUDY: Assessment of neurological syndromes prevalence and its clinical features in patients diagnosed with systemic lupus erythematosus. MATERIAL AND METHODS: The study comprised a group of 44 in- and outpatients of the Department of Dermatology and Venerology of Medical University of Lodz diagnosed with systemic lupus erythematosus and treated in 2006-2007...
January 2009: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
Selçuk Kaya, Uğur Kostakoğlu
Brucellosis is a significant health problem especially in developing countries as Turkey. Skeletal system involvement is relatively a common complication of human brucellosis, however genitourinary, cardiovascular, neurovascular and skin involvements are less frequent. In this case report, a 36-years-old female patient with fever, arthralgia, disseminated macular rash at the extremities and body and peripheral polineuropathy has been presented. The patient, living at a rural area, had a history of consumption of raw milk products...
January 2009: Mikrobiyoloji Bülteni
Ilona Kopyta, Sebastian Wardak
The Guillain-Barré syndrome is an acute inflammatory polineuropathy; it's frequency is established at the level of 1,3 cases/ 100 000 persons/ year. The main etiological factors concerned with the GBS occurrence are: Campylobacter jejuni, cytomegalovirus, Epstein-Barre virus, Mycoplasma pneumoniae. The authors present a case of the 15 years old boy with the clinical features of acute motor axonal polineuropathy and confirmed C. jejuni infection. Identification of C. jejuni isolate was based on colony morphology on CCDA plate (OXOID), characteristic motility, catalase, oxidase, hippurate hydrolysis and acetate hydrolysis...
2008: Medycyna Doświadczalna i Mikrobiologia
N Ovayolu, E Akarsu, E Madenci, S Torun, O Ucan, M Yilmaz
OBJECTIVE: This study was performed to identify the relationship between the quality of life and polyneuropathy which is one of the complications of diabetes. METHODS: Total 111 patients with diabetes mellitus were taken into the study as type 1 and type 2. Patients were accepted having polyneuropathy according to their electroneuromyography (ENMG) results. To evaluate the quality of life in the patients Short Form 36 (SF-36) and World Health Organization Quality of Life Questionnaire abbreviated version (WHOQOL-BREF) were used...
July 2008: International Journal of Clinical Practice
Maria Grazia Cassitto
BACKGROUND AND OBJECTIVES: The knowledge of heavy drinking and dependence on working behaviour is known and reflect the general community opinion and therefore is known in its more general and/or extreme manifestations (weekend deaths, dementia, polineuropathies). Less known and rarely measured are alcohol effects in heavy drinkers who have a high level of tolerance and only show manifestations which for a long time can be considered normal or seen as subjective peculiarities. DISCUSSION AND CONCLUSIONS: It is only in presence of serious accidents or dependence reactions that the drinking habit becomes evident...
November 2007: La Medicina del Lavoro
N Kostić, M Zamaklar, R Novaković, S Stajić
Parasympathetic function and plasma hPP response to a protein rich meal were evaluated in 105 insulin non-dependent diabetic patients: 20 with autonomic neuropathy (group A), diagnosed by Clonidin test; 35 patients with neurophysiological evidence of polyneuropath (group B); 30 patients with autonomic neuropathy and polineuropathy (group C), and 20 patients without any sign of neuropathy (group D). Plasma hPP levels were determined by RIA using an anti-hPP antiserum, kindly provided by Prof. S. R. Bloom (Hammersmith Hospital, London)...
November 1994: Srpski Arhiv za Celokupno Lekarstvo
Enric Pedrol, Teodoro Martín, Miguel Angel del Pozo, Juan Flores, José Sanz, José A Cartón, Juan-José Jusdado, Piedad Arazo, Esteve Ribera, Elisabet Deig et al.
BACKGROUND AND OBJECTIVE: Stavudine (d4T) has shown a favourable short and long-term tolerability profile. Nevertheless, its usage is currently decreasing due to some safety concerns. We aimed to evaluate the efficacy and safety of d4T low-dose-based regimens. PATIENTS AND METHOD: This was a multicenter and retrospective review chart of patients receiving standard doses of d4T for > or = 6 months (weight > 60 kg: 40 mg/12 h; weight < 60 kg: 30 mg/12 h) and having undetectable viral load for at least 3 months before the d4T dose reduction (weight > 60 kg: 30 mg/12 h; weight < 60 kg: 20 mg/12 h)...
September 22, 2007: Medicina Clínica
Wiesław Chudzik, Beata Kaczorowska, Monika Przybyła, Bartosz Chudzik, Małgorzata Gałka
Diabetic neuropathy is most common chronic complication of diabetes mellitus. It is responsible for substantial morbidity, increased mortality and impaired quality of life. Patogenesis of diabetic neuropathy is complex. Chronic hyperglycemia is a major factor induces nerve fibers injury. High level of glucose stimulate the polyol pathway causing osmotic stress and enhance reactive oxygen species generation, as well as it play an important role in diabetic angiopathy development. Distal symmetric polineuropathy is most common type of diabetic neuropathy...
January 2007: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
Marcos R G de Freitas, Osvaldo J M Nascimento, Maria Beatriz B P Harouche, Adolfo Vasconcelos, Heloy Darroz, Tânia Maria Escada
The Guilllain-Barré syndrome (GBS) is an acute predominantly demyelinating polyneuropathy. In many cases GBS is preceding by infection, immunization, surgery or trauma. Although there are a few reports of GBS after head trauma, there is no report of this syndrome after brachial plexus injury. We report on a 51 years-old man who presented GBS fifteen days after a brachial plexus trauma. The polineuropathy resolved completely in a few weeks. We believe that GBS was triggered by the trauma that evoked an immune mediated disorder producing inflammation and demyelination of the peripheral nerves...
December 2006: Arquivos de Neuro-psiquiatria
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