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https://www.readbyqxmd.com/read/27914133/lobeglitazone-a-novel-thiazolidinedione-improves-non-alcoholic-fatty-liver-disease-in-type-2-diabetes-its-efficacy-and-predictive-factors-related-to-responsiveness
#1
Yong Ho Lee, Jae Hyeon Kim, So Ra Kim, Heung Yong Jin, Eun Jung Rhee, Young Min Cho, Byung Wan Lee
Despite the rapidly increasing prevalence of non-alcoholic fatty liver disease (NAFLD) in type 2 diabetes (T2D), few treatment modalities are currently available. We investigated the hepatic effects of the novel thiazolidinedione (TZDs), lobeglitazone (Duvie) in T2D patients with NAFLD. We recruited drug-naïve or metformin-treated T2D patients with NAFLD to conduct a multicenter, prospective, open-label, exploratory clinical trial. Transient liver elastography (Fibroscan®; Echosens, Paris, France) with controlled attenuation parameter (CAP) was used to non-invasively quantify hepatic fat contents...
January 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/27913924/shear-wave-elastography-reveals-different-degrees-of-passive-and-active-stiffness-of-the-neck-extensor-muscles
#2
Angela V Dieterich, Ricardo J Andrade, Guillaume Le Sant, Deborah Falla, Frank Petzke, François Hug, Antoine Nordez
PURPOSE: The neck extensor muscles contribute to spinal support and posture while performing head and neck motion. Muscle stiffness relates to passive elasticity (support) and active tensioning (posture and movement) of muscle. It was hypothesized that support and motion requirements are reflected in the distribution of stiffness between superficial and deep neck extensor muscles. METHODS: In ten healthy participants, shear modulus (stiffness) of five neck extensor muscles was determined in prone at rest and during isometric head lift at three intensities using shear wave elastography...
December 2, 2016: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/27913889/ocular-pharmacology-of-tear-film-dry-eye-and-allergic-conjunctivitis
#3
Shilpa Gulati, Sandeep Jain
Dry Eye Disease (DED) is "a multifactorial disease of the tears and ocular surface that results in symptoms of discomfort, visual disturbance, and tear-film instability with potential damage to the ocular surface." DED comprises two etiologic categories: aqueous-deficient dry eye (ADDE) and evaporative dry eye (EDE). Diagnostic workup of DED should include clinical history, symptom questionnaire, fluorescein TBUT, ocular surface staining grading, Schirmer I/II, lid and meibomian pathology, meibomian expression, followed by other available tests...
December 3, 2016: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/27913593/higher-heart-rate-variability-is-associated-with-vmpfc-activity-and-increased-resistance-to-temptation-in-dietary-self-control-challenges
#4
Silvia U Maier, Todd A Hare
: Higher levels of self-control in decision making have been linked to better psychosocial and physical health. A similar link to health outcomes has been reported for heart rate variability (HRV), a marker of physiological flexibility. Here, we sought to link these two, largely separate, research domains by testing the hypothesis that greater HRV would be associated with better dietary self-control in humans. Specifically, we examined whether total HRV at sedentary rest (measured as the standard deviation of normal-to-normal intervals, SDNN) can serve as a biomarker for the neurophysiological adaptability that putatively underlies self-controlled behavior...
December 2, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27912236/prognostic-role-of-pten-gene-expression-in-breast-cancer-patients-from-north-east-iran
#5
Rahim Golmohammadi, Mohammad Hassan Rakhshani, Ali Reza Moslem, Akbar Pejhan
Background: PTEN protein is one of the most important tumour suppressor factors which is detectable by immunohistochemistry. The goal of the present study was to investigate the prognostic role of PTEN gene expression in breast cancer patients. Materials and Methods: This descriptive-analytical study was conducted on 100 breast cancer patients referred to Sabzevar hospitals in the north-east of Iran between 2010 and 2011, who were followed up to 2015. PTEN gene expression in tissue samples was determined using specific monoclonal antibodies and data were analyzed using Chi-square test and Fisher’s exact test...
January 9, 2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27912204/incremental-diagnostic-value-of-combined-quantitative-and-qualitative-parameters-of-magnetocardiography-to-detect-coronary-artery-disease
#6
Eun-Seok Shin, Yat-Yin Lam, Ae-Young Her, Johannes Brachmann, Friedrich Jung, Jai-Wun Park
BACKGROUND/OBJECTIVES: Magnetocardiography (MCG) has been proposed as a non-invasive and functional technique with high accuracy for diagnosis of myocardial ischemia. This study sought to investigate the incremental diagnostic value of combined quantitative and qualitative parameters of MCG to detect coronary artery disease (CAD). METHODS: Ninety six patients with suspected CAD who underwent coronary angiography were enrolled in the analysis to test the diagnostic accuracy of 2 MCG parameters (a quantitative parameter of the percent change of ST-segment fluctuation score and a qualitative parameter of non-dipole phenomenon)...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27912107/limits-to-tdcs-effects-in-language-failures-to-modulate-word-production-in-healthy-participants-with-frontal-or-temporal-tdcs
#7
Samuel J Westwood, Andrew Olson, R Chris Miall, Raffaele Nappo, Cristina Romani
Transcranial direct current stimulation (tDCS) is a method of non-invasive brain stimulation widely used to modulate cognitive functions. Recent studies, however, suggests that effects are unreliable, small and often non-significant at least when stimulation is applied in a single session to healthy individuals. We examined the effects of frontal and temporal lobe anodal tDCS on naming and reading tasks and considered possible interactions with linguistic activation and selection mechanisms as well as possible interactions with item difficulty and participant individual variability...
November 3, 2016: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/27911452/rationally-encapsulated-gold-nanorods-improving-both-linear-and-nonlinear-photoacoustic-imaging-contrast-in-vivo
#8
Fei Gao, Linyi Bai, Siyu Liu, Ruochong Zhang, Jingtao Zhang, Xiaohua Feng, Yuanjin Zheng, Yanli Zhao
Photoacoustic tomography has emerged as a promising non-invasive imaging technique that integrates the merits of high optical contrast with high ultrasound resolution in deep scattering medium. Unfortunately, the blood background in vivo seriously impedes the quality of imaging due to its comparable optical absorption with contrast agents, especially in conventional linear photoacoustic imaging modality. In this study, we demonstrated that two hybrids consisting of gold nanorods (Au NRs) and zinc tetra(4-pyridyl)porphyrin (ZnTPP) exhibited a synergetic effect in improving optical absorption, conversion efficiency from light to heat, and thermoelastic expansion, leading to a notable enhancement in both linear (four times greater) and nonlinear (more than six times) photoacoustic signals as compared with conventional Au NRs...
December 2, 2016: Nanoscale
https://www.readbyqxmd.com/read/27911406/ultrasound-guided-botulinum-toxin-a-injections-a-method-of-treating-sialorrhea
#9
Pierangelo Barbero, Marco Busso, Carlo Alberto Artusi, Stefania De Mercanti, Marco Tinivella, Andrea Veltri, Luca Durelli, Marinella Clerico
Neurological diseases can be complicated by sialorrhea, an excessive flow of saliva. Patients suffering from moderate to severe sialorrhea have an impaired quality of life, often worsened by correlated complications such as aspiration pneumonia, oral infections, dental caries, and maceration of the skin. Diverse therapeutic approaches have been proposed for the treatment of sialorrhea, including surgery and the use of anticholinergic agents, with limited results and the possible occurrence of serious adverse events...
November 9, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27911394/confirmation-of-myocardial-ischemia-and-reperfusion-injury-in-mice-using-surface-pad-electrocardiography
#10
Stephanie L C Scofield, Krishna Singh
Many animal models have been established for the study of myocardial remodeling and heart failure due to its status as the number one cause of mortality worldwide. In humans, a pathologic occlusion forms in a coronary artery and reperfusion of that occluded artery is considered essential to maintain viability of the myocardium at risk. Although essential for myocardial recovery, reperfusion of the ischemic myocardium creates its own tissue injury. The physiologic response and healing of an ischemia/reperfusion injury is different from a chronic occlusion injury...
November 24, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27911387/use-of-a-filter-cartridge-for-filtration-of-water-samples-and-extraction-of-environmental-dna
#11
Masaki Miya, Toshifumi Minamoto, Hiroki Yamanaka, Shin-Ichiro Oka, Keiichi Sato, Satoshi Yamamoto, Tetsuya Sado, Hideyuki Doi
Recent studies demonstrated the use of environmental DNA (eDNA) from fishes to be appropriate as a non-invasive monitoring tool. Most of these studies employed disk fiber filters to collect eDNA from water samples, although a number of microbial studies in aquatic environments have employed filter cartridges, because the cartridge has the advantage of accommodating large water volumes and of overall ease of use. Here we provide a protocol for filtration of water samples using the filter cartridge and extraction of eDNA from the filter without having to cut open the housing...
November 25, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27911338/sleepiness-and-sleep-related-breathing-disorders-in-myotonic-dystrophy-and-responses-to-treatment-a-prospective-cohort-study
#12
Sophie D West, Hanns Lochmüller, Joan Hughes, Antonio Atalaia, Chiara Marini-Bettolo, Simon V Baudouin, Kirstie N Anderson
OBJECTIVE: We conducted prospective assessments in people with myotonic dystrophy type 1 (DM1) with daytime sleepiness, provided targeted therapies and assessed response. METHODS: Patients had overnight sleep assessments. Treatment with continuous positive airway pressure (CPAP) for OSA, non-invasive ventilation (NIV) for respiratory failure, modafinil for excessive daytime sleepiness were commenced. RESULTS: 120 people were studied: mean age 46...
November 29, 2016: Journal of Neuromuscular Diseases
https://www.readbyqxmd.com/read/27911134/split-face-histological-and-biochemical-evaluation-of-tightening-efficacy-using-temperature-and-impedance-controlled-continuous-non-invasive-radiofrequency-energy
#13
Sylvie Boisnic, Marc Divaris, Marie-Christine Branchet, Andrew Anthony Nelson
BACKGROUND: Bi-polar radiofrequency (RF) is capable of heating dermal collagen fibers and inducing skin tightening by collagen remodelling. OBJECTIVE: To substantiate safety and improvement of skin laxity following skin heating with a novel temperature and impedance controlled non-invasive radiofrequency (RF) device by histological and biochemical evaluations. METHODS: A split-face study was performed on 4 subjects that underwent 8 weekly RF sessions on one side of their face, leaving the other side an untreated control and then underwent face-lift procedure...
December 2, 2016: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/27910948/improved-in-cell-structure-determination-of-proteins-at-near-physiological-concentration
#14
Teppei Ikeya, Tomomi Hanashima, Saori Hosoya, Manato Shimazaki, Shiro Ikeda, Masaki Mishima, Peter Güntert, Yutaka Ito
Investigating three-dimensional (3D) structures of proteins in living cells by in-cell nuclear magnetic resonance (NMR) spectroscopy opens an avenue towards understanding the structural basis of their functions and physical properties under physiological conditions inside cells. In-cell NMR provides data at atomic resolution non-invasively, and has been used to detect protein-protein interactions, thermodynamics of protein stability, the behavior of intrinsically disordered proteins, etc. in cells. However, so far only a single de novo 3D protein structure could be determined based on data derived only from in-cell NMR...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27910889/direct-imaging-of-defect-formation-in-strained-organic-flexible-electronics-by-scanning-kelvin-probe-microscopy
#15
Tobias Cramer, Lorenzo Travaglini, Stefano Lai, Luca Patruno, Stefano de Miranda, Annalisa Bonfiglio, Piero Cosseddu, Beatrice Fraboni
The development of new materials and devices for flexible electronics depends crucially on the understanding of how strain affects electronic material properties at the nano-scale. Scanning Kelvin-Probe Microscopy (SKPM) is a unique technique for nanoelectronic investigations as it combines non-invasive measurement of surface topography and surface electrical potential. Here we show that SKPM in non-contact mode is feasible on deformed flexible samples and allows to identify strain induced electronic defects...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27910569/l-shell-spectroscopic-diagnostics-of-radiation-from-krypton-hed-plasma-sources
#16
E E Petkov, A S Safronova, V L Kantsyrev, V V Shlyaptseva, R S Rawat, K S Tan, P Beiersdorfer, N Hell, G V Brown
X-ray spectroscopy is a useful tool for diagnosing plasma sources due to its non-invasive nature. One such source is the dense plasma focus (DPF). Recent interest has developed to demonstrate its potential application as a soft x-ray source. We present the first spectroscopic studies of krypton high energy density plasmas produced on a 3 kJ DPF device in Singapore. In order to diagnose spectral features, and to obtain a more comprehensive understanding of plasma parameters, a new non-local thermodynamic equilibrium L-shell kinetic model for krypton was developed...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910541/research-on-the-best-measurement-situation-between-optical-probe-and-tissue-surfaces-in-non-invasive-detection
#17
Xuyao Yu, Rong Liu, Hui Yu, Jiao Wang, Jun Wang, Kexin Xu
Near-infrared spectroscopy is often used for the non-invasive detection of composition in the human body, such as that of blood glucose and haemoglobin, due to its high penetration depth into tissues. Although it is feasible to position the optical probe precisely, contact situation between probe and human tissues is a difficult problem to determine because of physiological tremor and mechanical performance of bio-soft tissue. Here, we proposed a novel estimation method for the situation between the optical probe and tissue surfaces based on the dynamic auto-correlation matrix of two-dimensional correlation spectroscopy (2DCOS) and radar chart...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910223/synthesis-and-preliminary-evaluation-of-a-99m-tc-labeled-folate-pamam-dendrimer-for-fr-imaging
#18
Manli Song, Zhide Guo, Mengna Gao, Changrong Shi, Duo Xu, Linyi You, Xiaowei Wu, Xinhui Su, Rongqiang Zhuang, Weimin Pan, Ting Liu, Xianzhong Zhang
Folate receptor is an ideal target for tumor-specific diagnostic and therapeutic. The aim of this study was to synthesize (99m) Tc-labeled folate-polyamidoamine dendrimer modified with 2-hydrazinonicotinic acid ((99m) Tc-HP3 FA) for FR imaging. The (99m) Tc-HP3 FA conjugate was prepared using N-tris-(hydroxymethyl)-methylglycine and trisodium triphenylphosphine-3,3',3″-trisulfonate as coligands. Physicochemical properties, in vitro cell uptake study, and in vivo micro-single-photon emission computed tomography/CT imaging were performed...
November 7, 2016: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/27910113/diagnostic-accuracy-of-faecal-biomarkers-in-detecting-colorectal-cancer-and-adenoma-in-symptomatic-patients
#19
M M Widlak, C L Thomas, M G Thomas, C Tomkins, S Smith, N O'Connell, S Wurie, L Burns, C Harmston, C Evans, C U Nwokolo, B Singh, R P Arasaradnam
BACKGROUND: The diagnosis of colorectal cancer (CRC) can be difficult as symptoms are variable with poor specificity. Thus, there is a quest for simple, non-invasive testing that can help streamline those with significant colonic pathology. AIM: To assess using faecal immunochemical test for haemoglobin (FIT) or faecal calprotectin (FCP) to detect CRC and adenoma in symptomatic patients referred from primary care. METHODS: A total of 799 referred for urgent lower gastrointestinal investigations were prospectively recruited...
December 1, 2016: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27910005/doppler-images-of-intra-pulmonary-shunt-within-atelectasis-in-anesthetized-children
#20
Cecilia M Acosta, Gerardo Tusman, Mauro Costantini, Camila Echevarría, Sergio Pollioto, Diego Abrego, Fernando Suarez-Sipmann, Stephan H Böhm
BACKGROUND: Doppler images of pulmonary vessels in pulmonary diseases associated with subpleural consolidations have been described. Color Doppler easily identifies such vessels within consolidations while spectral Doppler analysis allows the differentiation between pulmonary and bronchial arteries. Thus, Doppler helps in diagnosing the nature of consolidations. To our knowledge, Doppler analysis of pulmonary vessels within anesthesia-induced atelectasis has never been described before...
December 2016: Critical Ultrasound Journal
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