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https://www.readbyqxmd.com/read/29656357/monitoring-oh-pcbs-in-pcb-transport-worker-s-urine-as-a-non-invasive-exposure-assessment-tool
#1
Yuki Haga, Motoharu Suzuki, Chisato Matsumura, Toshihiro Okuno, Masahiro Tsurukawa, Kazuo Fujimori, Narayanan Kannan, Roland Weber, Takeshi Nakano
In this study, we analyzed hydroxylated polychlorinated biphenyls (OH-PCBs) in urine of both PCB transport workers and PCB researchers. A method to monitor OH-PCB in urine was developed. Urine was solid-phase extracted with 0.1% ammonia/ methanol (v/v) and glucuronic acid/sulfate conjugates and then decomposed using β-glucuronidase/arylsulfatase. After alkaline digestion/derivatization, the concentration of OH-PCBs was determined by HRGC/HRMS-SIM. In the first sampling campaign, the worker's OH-PCB levels increased several fold after the PCB waste transportation work, indicating exposure to PCBs...
April 14, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29656272/characterisation-of-cardiac-autonomic-function-in-multiple-sclerosis-based-on-spontaneous-changes-of-heart-rate-and-blood-pressure
#2
Fatemeh Shirbani, Edward Barin, Yi-Ching Lee, Karl Ng, John Douglas Edward Parratt, Mark Butlin, Alberto P Avolio
BACKGROUND: Prevalence of cardiovascular autonomic dysfunction (CAD) in multiple sclerosis (MS) varies between studies. Cardiac autonomic function is usually assessed by cardiovascular reflex tests. We hypothesized that MS is associated with CAD, quantifiable by non-invasive means including quantification of baroreceptor sensitivity (BRS) and heart rate variability. METHODS: In this study a comprehensive suite of cardiovascular autonomic tests based only on the spontaneous changes of heart rate and blood pressure was applied to 23 MS patients and age and gender-matched controls...
March 27, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29655989/in-vivo-migration-of-mesenchymal-stem-cells-to-burn-injury-sites-and-their-therapeutic-effects-in-a-living-mouse-model
#3
Eun Jung Oh, Ho Won Lee, Senthilkumar Kalimuthu, Tae Jung Kim, Hyun Mi Kim, Se Hwan Baek, Liya Zhu, Ji Min Oh, Seung Hyun Son, Ho Yun Chung, Byeong-Cheol Ahn
Mesenchymal stem cell (MSC)-based therapy has emerged as a promising therapeutic strategy for tissue regeneration and repair. In this study, we non-invasively monitored the tracking of MSCs toward burn injury sites using MSCs expressing firefly luciferase (Fluc) gene in living mice, and evaluated the effects of the MSCs at the injury site. Murine MSCs co-expressing Fluc and green fluorescent protein (GFP) were established using a retroviral system (referred to as MSC/Fluc). To evaluate the ability of MSC migration toward burn injury sites, cutaneous burn injury was induced in the dorsal skin of mice...
April 12, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29655957/ectopic-cushing-syndrome-report-of-9-cases
#4
Marta Araujo Castro, Nuria Palacios García, Javier Aller Pardo, Cristina Izquierdo Alvarez, Laura Armengod Grao, Javier Estrada García
INTRODUCTION: Ectopic Cushing's syndrome (ECS) is a rare condition caused by ACTH secretion by extrapituitary tumors. Its low frequency makes it difficult to acquire experience in its management. The aim of this study was to describe patients with ECS seen at the endocrinology department of a tertiary hospital over 15 years. METHODS: This was a retrospective study of the clinical, biochemical and radiographic data, treatment, and course of patients with ECS seen from 2000 to 2015...
April 11, 2018: Endocrinología, Diabetes y Nutrición
https://www.readbyqxmd.com/read/29655938/delineation-of-early-brain-development-from-fetuses-to-infants-with-diffusion-mri-and-beyond
#5
REVIEW
Minhui Ouyang, Jessica Dubois, Qinlin Yu, Pratik Mukherjee, Hao Huang
Dynamic macrostructural and microstructural changes take place from the mid-fetal stage to 2 years after birth. Delineating brain structural changes during this early developmental period provides new insights into the complicated processes of both typical brain development and the pathological mechanisms underlying various psychiatric and neurological disorders including autism, attention deficit hyperactivity disorder and schizophrenia. Decades of histological studies have identified strong spatial and functional gradients of maturation in human brain gray and white matter...
April 12, 2018: NeuroImage
https://www.readbyqxmd.com/read/29655410/non-orthodontic-intervention-and-non-nutritive-sucking-behaviours-a-literature-review
#6
REVIEW
Liyana Tanny, Boyen Huang, Noel Ye Naung, Geoffrey Currie
Anterior open bite (AOB) is one of the most complex malocclusions to manage. AOB is caused by either by skeletal, genetic or environmental factors. Numerous treatment options are currently utilised to manage AOB. These vary from non-invasive behavioural shaping to orthodontic and surgical interventions. This paper reviews the available orthodontic and non-orthodontic interventions used in the management of AOB. The literature review was carried out using the PubMed search engine from the first of January 2000 to the first of June 2017...
April 2018: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/29653351/early-non-invasive-detection-of-breast-cancer-using-exhaled-breath-and-urine-analysis
#7
Or Herman-Saffar, Zvi Boger, Shai Libson, David Lieberman, Raphael Gonen, Yehuda Zeiri
The main focus of this pilot study is to develop a statistical approach that is suitable to model data obtained by different detection methods. The methods used in this study examine the possibility to detect early breast cancer (BC) by exhaled breath and urine samples analysis. Exhaled breath samples were collected from 48 breast cancer patients and 45 healthy women that served as a control group. Urine samples were collected from 37 patients who were diagnosed with breast cancer based on physical or mammography tests prior to any surgery, and from 36 healthy women...
April 4, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29652997/-application-of-droplet-digital-pcr-for-non-invasive-prenatal-diagnosis-of-single-gene-disease-in-two-families
#8
Peiwen Xu, Yang Zou, Jie Li, Sexin Huang, Ming Gao, Ranran Kang, Hongqiang Xie, Lijuan Wang, Junhao Yan, Yuan Gao
OBJECTIVE: To assess the value of droplet digital PCR (ddPCR) for non-invasive prenatal diagnosis of single gene disease in two families. METHODS: Paternal mutation in cell-free DNA derived from the maternal blood and amniotic fluid DNA was detected by ddPCR. Suspected mutation in the amniotic fluid DNA was verified with Sanger sequencing. RESULTS: The result of ddPCR and Sanger sequencing indicated that the fetuses have carried pathogenic mutations from the paternal side in both families...
April 10, 2018: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/29652904/first-night-effect-on-sleep-time-in-dairy-cows
#9
Emma Ternman, Matti Pastell, Laura Hänninen, Sigrid Agenäs, Per P Nielsen
In human sleep studies, the probability of discomfort from the electrodes and the change in environment usually results in first-night recordings being discarded. Sleep recordings from the first night in human subjects often differ in amount of REM (rapid eye movement) sleep and the overall sleep architecture. This study investigated whether recordings of sleep states in dairy cows also show a first-night effect. Non-invasive electrophysiological recordings were carried out on nine cows of the Swedish Red breed during three consecutive 24-hour periods (recording days 1-3)...
2018: PloS One
https://www.readbyqxmd.com/read/29652902/relations-between-right-ventricular-morphology-and-clinical-electrical-and-genetic-parameters-in-brugada-syndrome
#10
Belinda Gray, Ganesh Kumar Gnanappa, Richard D Bagnall, Giuseppe Femia, Laura Yeates, Jodie Ingles, Charlotte Burns, Rajesh Puranik, Stuart M Grieve, Christopher Semsarian, Raymond W Sy
BACKGROUND: Increasing evidence suggests the presence of structural changes affecting the right ventricular outflow tract (RVOT) in patients with Brugada Syndrome (BrS). The aim of this study was to characterise the RV morphology in BrS and explore associations between morphologic, clinical, electrical, and genetic parameters using non-invasive multimodality testing. METHODS: Consecutive BrS patients (recruited 2013-2015) underwent clinical assessment, dedicated RV imaging using cardiac magnetic resonance (CMR) imaging (unless contra-indicated), electrical assessment (electrocardiogram, Holter monitoring, signal-averaged ECG[SAECG]) and genotyping...
2018: PloS One
https://www.readbyqxmd.com/read/29652794/the-voice-of-the-heart-vowel-like-sound-in-pulmonary-artery-hypertension
#11
Mohamed Elgendi, Prashant Bobhate, Shreepal Jain, Long Guo, Jennifer Rutledge, Yashu Coe, Roger Zemp, Dale Schuurmans, Ian Adatia
Increased blood pressure in the pulmonary artery is referred to as pulmonary hypertension and often is linked to loud pulmonic valve closures. For the purpose of this paper, it was hypothesized that pulmonary circulation vibrations will create sounds similar to sounds created by vocal cords during speech and that subjects with pulmonary artery hypertension (PAH) could have unique sound signatures across four auscultatory sites. Using a digital stethoscope, heart sounds were recorded at the cardiac apex, 2nd left intercostal space (2LICS), 2nd right intercostal space (2RICS), and 4th left intercostal space (4LICS) undergoing simultaneous cardiac catheterization...
April 13, 2018: Diseases (Basel)
https://www.readbyqxmd.com/read/29652661/combined-brain-and-heart-magnetic-resonance-imaging-in-systemic-vasculitides-fiction-or-real-need
#12
REVIEW
Sophie I Mavrogeni, George Kitas, Hildo J Lamb, Klearchos Psychoyios, Theodoros Dimitroulas, Loukia Koutsogeorgopoulou, Kyriaki Boki, Vasiliki Vartela, Genovefa Kolovou, George Markousis-Mavrogenis, Cees G Kallenberg, Loic Guillevin, Dimitrios Vassilopoulos
Systemic vasculitides (SVs) is a group of diseases characterised by inflammation/necrosis of the blood vessel wall in various organs. Simultaneous brain and heart involvement is a cause of increased morbidity/mortality in SV. We aimed to present evidence of concurrent brain/heart involvement in SV and the role of a combined brain/heart magnetic resonance imaging (MRI) in their risk stratification. Cerebral vasculitis (CV) can be presented as focal deficits, seizures, headache, neuropsychiatric manifestations or cognitive dysfunction and cardiovascular disease (CVD) as myocardial/vascular inflammation, perfusion/function defects and fibrosis...
April 10, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29652130/in-vivo-targeted-responsive-and-synergistic-cancer-nanotheranostics-by-mri-guided-synergistic-hifu-ablation-and-chemotherapy
#13
Hailin Tang, Yuan Guo, Li Peng, Hui Fang, Zhigang Wang, Yuanyi Zheng, Haitao Ran, Yu Chen
As one of the most representative non-invasive therapeutic modalities, high-intensity focused ultrasound (HIFU) has shown the great promise for cancer therapy, but its low therapeutic efficacy and biosafety significantly hinder the further extensive clinical translation and application. In this work, we report on the construction of a multifunctional theranostic nanoplatform to synergistically enhance the HIFU-therapeutic efficacy based on nanomedicine. A targeted and temperature-responsive theranostic nanoplatform (PFH/DOX@PLGA/Fe3O4-FA) has been designed and fabricated for efficient ultrasound/magnetic resonance dual-modality imaging-guided HIFU/chemo synergistic therapy...
April 13, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29652111/actual-diagnosis-of-helicobacter-pylori-infection
#14
Philippe Lehours
Helicobacter pylori colonizes the stomach of half of humanity. The prevalence of this infection is higher among people of low socioeconomic status and from developing countries. In the absence of effective antibiotic treatment, the infection persists decades or even lifetime. The diagnosis of H. pylori can be made by invasive methods when biopsies are obtained: culture, histological examination, polymerase chain reaction or rapid urease test. Non-invasive methods have been developed, including the urea breath test, a test of high reliability, particularly suitable for post treatment monitoring, but also the fecal antigen test, as well as the detection of antibodies in the serum...
April 12, 2018: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/29652088/non-invasive-brain-stimulation-techniques-for-chronic-pain
#15
REVIEW
Neil E O'Connell, Louise Marston, Sally Spencer, Lorraine H DeSouza, Benedict M Wand
BACKGROUND: This is an updated version of the original Cochrane Review published in 2010, Issue 9, and last updated in 2014, Issue 4. Non-invasive brain stimulation techniques aim to induce an electrical stimulation of the brain in an attempt to reduce chronic pain by directly altering brain activity. They include repetitive transcranial magnetic stimulation (rTMS), cranial electrotherapy stimulation (CES), transcranial direct current stimulation (tDCS), transcranial random noise stimulation (tRNS) and reduced impedance non-invasive cortical electrostimulation (RINCE)...
April 13, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29651955/increases-in-peripheral-systolic-pressure-levels-and-z-score-associate-gradual-aortic-pressure-increase-and-functional-arterial-impairment-in-children-and-adolescents
#16
Yanina Zocalo, Mariana Marin, Santiago Curcio, Victoria Garcia-Espinosa, Pedro Chiesa, Gustavo Giachetto, Edmundo I Cabrera-Fischer, Daniel Bia
BACKGROUND: Arterial changes associated with children and adolescents high blood pressure (HBP) states would vary depending on the arterial type, arterial indexes considered and/or on blood pressure (BP) levels. AIMS: To determine in children and adolescents: 1) if there is gradual structural-functional arterial impairment associated with gradual peripheral (brachial) systolic BP (pSBP) level or z-score increases, and 2) whether subjects with HBP levels and those with normal BP differ in the profiles of arterial changes associated with pSBP deviations...
April 13, 2018: Current Hypertension Reviews
https://www.readbyqxmd.com/read/29651940/proteomics-in-human-assisted-reproduction
#17
Mauro Bibancos De Rose, Mariana Moraes Piccolomini
Assisted reproduction techniques (ART) have significantly advanced since the first successful in vitro fertilization (IVF). However, most in vitro-produced embryos fail to implant. Key steps in ART are the correct infertility diagnosis, in order to manage the individual treatments, and the assessment of gamete and embryo viability, to identify the embryo with the best implantation potential. Non-invasive approaches to correctly diagnose infertility and to access embryo development potential have the advantages of increasing the knowledge of embryo physiology, therefore allowing the development of methods to predict developmental competence and viability...
April 12, 2018: Protein and Peptide Letters
https://www.readbyqxmd.com/read/29651805/editorial-comment-to-non-invasive-assessment-of-kidney-allograft-fibrosis-with-shear-wave-elastography-a-radiological-pathological-correlation-analysis
#18
Ivana Mikolasevic, Tomislav Bokun, Tajana Filipec-Kanizaj
No abstract text is available yet for this article.
April 12, 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29651661/high-arctic-lemmings-remain-reproductively-active-under-predator-induced-elevated-stress
#19
Dominique Fauteux, Gilles Gauthier, Dominique Berteaux, Rupert Palme, Rudy Boonstra
Non-consumptive effects of predation have rarely been assessed in wildlife populations even though their impact could be as important as lethal effects. Reproduction of individuals is one of the most important demographic parameters that could be affected by predator-induced stress, which in turn can have important consequences on population dynamics. We studied non-consumptive effects of predation on the reproductive activity (i.e., mating and fertilization) of a cyclic population of brown lemmings exposed to intense summer predation in the Canadian High Arctic...
April 12, 2018: Oecologia
https://www.readbyqxmd.com/read/29651540/identifying-non-invasive-tools-to-distinguish-acute-myocarditis-from-dilated-cardiomyopathy-in-children
#20
Divya Suthar, Debra A Dodd, Justin Godown
There is often a diagnostic dilemma in pediatric patients presenting with depressed ventricular function, as myocarditis and dilated cardiomyopathy (DCM) of other etiologies can appear very similar. Accurate identification is critical to guide treatment and to provide families with the most accurate expectation of long-term outcomes. The objective of this study was to identify patterns of clinical presentation and to assess non-invasive measures to differentiate patients with acute myocarditis from other forms of DCM...
April 12, 2018: Pediatric Cardiology
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