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https://www.readbyqxmd.com/read/28110445/non-invasive-photodynamic-therapy-in-brain-cancer-by-use-of-tb-3-doped-laf3-nanoparticles-in-combination-with-photosensitizer-through-x-ray-irradiation-a-proof-of-concept-study
#1
Min-Hua Chen, Yi-Jhen Jenh, Sheng-Kai Wu, Yo-Shen Chen, Nobutaka Hanagata, Feng-Huei Lin
The use of photodynamic therapy (PDT) in the treatment of brain cancer has produced exciting results in clinical trials over the past decade. PDT is based on the concept that a photosensitizer exposed to a specific light wavelength produces the predominant cytotoxic agent, to destroy tumor cells. However, delivering an efficient light source to the brain tumor site is still a challenge. The light source should be delivered by placing external optical fibers into the brain at the time of surgical debulking of the tumor...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28110410/neurophysiological-assessment-of-brain-dysfunction-in-critically-ill-patients-an-update
#2
REVIEW
Eric Azabou, Catherine Fischer, Jean Michel Guerit, Djillali Annane, François Mauguiere, Fréderic Lofaso, Tarek Sharshar
The aim of this review was to provide up-to-date information about the usefulness of clinical neurophysiology testing in the management of critically ill patients. Evoked potentials (EPs) and electroencephalogram (EEG) are non-invasive clinical neurophysiology tools that allow an objective assessment of the central nervous system's function at the bedside in intensive care unit (ICU). These tests are quite useful in diagnosing cerebral complications, and establishing the vital and functional prognosis in ICU...
January 21, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28110181/dynamic-measurement-of-surface-strain-distribution-on-the-foot-during-walking
#3
Kohta Ito, Kosuke Maeda, Ikumi Fujiwara, Koh Hosoda, Takeo Nagura, Taeyong Lee, Naomichi Ogihara
To clarify the mechanism underlying the development of foot disorders such as diabetic ulcers and deformities, it is important to understand how the foot surface elongates and contracts during gait. Such information is also helpful for improving the prevention and treatment of foot disorders. We therefore measured temporal changes in the strain distribution on the foot surface during human walking. Five adult male participants walked across a glass platform placed over an angled mirror set in a wooden walkway at a self-selected speed and the dorsolateral and plantar surfaces of the foot were filmed using two pairs of synchronized high-speed cameras...
December 18, 2016: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28110138/contributions-to-ultrasound-monitoring-of-the-process-of-milk-curdling
#4
Antonio Jiménez, Montaña Rufo, Jesús M Paniagua, Abel T Crespo, M Patricia Guerrero, M José Riballo
Ultrasound evaluation permits the state of milk being curdled to be determined quickly and cheaply, thus satisfying the demands faced by today's dairy product producers. This paper describes the non-invasive ultrasonic method of in situ monitoring the changing physical properties of milk during the renneting process. The basic objectives of the study were, on the one hand, to confirm the usefulness of conventional non-destructive ultrasonic testing (time-of-flight and attenuation of the ultrasound waves) in monitoring the process in the case of ewe's milk, and, on the other, to include other ultrasound parameters which have not previously been considered in studies on this topic, in particular, parameters provided by the Fast Fourier Transform technique...
January 10, 2017: Ultrasonics
https://www.readbyqxmd.com/read/28109967/subclavian-artery-disease-diagnosis-and-therapy
#5
REVIEW
Tisa Saha, Syed Yaseen Naqvi, Omar Abine Ayah, Daniel McCormick, Sheldon Goldberg
The diagnosis of brachiocephalic disease is often overlooked. Symptoms include arm claudication and vertebro-basilar insufficiency. In patients who have had the use of the internal mammary artery for coronary bypass surgery, the development of symptoms of myocardial ischemia should alert the clinician to the possibility of subclavian artery stenosis. Also in patients who have had axillo-femoral bypass, lower extremity claudication may occur. Recognition involves physical examination and accurate non-invasive testing...
January 18, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28109737/retinal-oxygen-from-animals-to-humans
#6
REVIEW
Robert A Linsenmeier, Hao F Zhang
This article discusses retinal oxygenation and retinal metabolism by focusing on measurements made with two of the principal methods used to study O2 in the retina: measurements of PO2 with oxygen-sensitive microelectrodes in vivo in animals with a retinal circulation similar to that of humans, and oximetry, which can be used non-invasively in both animals and humans to measure O2 concentration in retinal vessels. Microelectrodes uniquely have high spatial resolution, allowing the mapping of PO2 in detail, and when combined with mathematical models of diffusion and consumption, they provide information about retinal metabolism...
January 18, 2017: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/28109728/the-utility-of-hair-cortisol-concentrations-in-the-prediction-of-ptsd-symptoms-following-traumatic-physical-injury
#7
Maria L Pacella, Bryce Hruska, Susann Steudte-Schmiedgen, Richard L George, Douglas L Delahanty
RATIONALE: Although cortisol alterations have been associated with posttraumatic stress disorder (PTSD) and PTSD symptoms (PTSS), the direction of association is mixed. Cortisol which is measured in blood, saliva, or urine is subject to transient factors that may confound results. Recent advances in cortisol sampling techniques provide novel opportunities to address these inconsistencies. Hair cortisol sampling is a non-invasive method for the retrospective assessment of long-term integrated cortisol, yet its utility at predicting PTSS has not been assessed in acute injury victims...
January 6, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28109555/surface-area-estimation-for-application-of-wound-care
#8
Dominik Spinczyk, Monika Wideł
Estimation of surface for application of wound care is one of the important prognostic factors for wound healing. The objective of this study is to measure a surface area estimation for application of wound care. Non-invasive, 3D surface reconstruction methodology using two monocular cameras was implemented and verified. The measurement environment was setup on 10 patients with different kind of wounds. Phantom measurements, with known dimensions, show accuracy of implemented method below 11 percent The patient's measurements has the same accuracy...
January 16, 2017: Injury
https://www.readbyqxmd.com/read/28109548/comparison-between-high-frequency-ultrasonography-and-histological-assessment-reveals-weak-correlation-for-measurements-of-scar-tissue-thickness
#9
Natacha A Agabalyan, Samuel Su, Sarthak Sinha, Vincent Gabriel
OBJECTIVE: Current methods for evaluating scar tissue volume following burns have shortcomings. The Vancouver Burn Scar scale is subjective, leading to a high variability in assessment. Although histological assessment via punch biopsy can discriminate between the different layers of skin, such an approach is invasive, inefficient, and detrimental to patient experience and wound healing. This study investigates the accuracy of high-frequency ultrasonography, a non-invasive alternative to histology, for measuring dermal and epidermal thickness in scar tissue...
January 18, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28109531/diffusion-weighted-imaging-dwi-of-hepatocellular-carcinomas-a-retrospective-analysis-of-the-correlation-between-qualitative-and-quantitative-dwi-and-tumour-grade
#10
T Jiang, J H Xu, Y Zou, R Chen, L R Peng, Z D Zhou, M Yang
AIM: To evaluate the application of qualitative and quantitative diffusion-weighted imaging (DWI) in predicting the histological grade of hepatocellular carcinoma (HCC). MATERIALS AND METHODS: Two hundred and fifty-four patients with pathologically confirmed HCC who underwent hepatic DWI on a 1.5-T platform (b = 0, 600 s/mm(2)) were evaluated retrospectively. HCCs were divided into well-, moderately, and poorly differentiated groups. The relationships between naked-eye signal intensity (SI), SI values, apparent diffusion coefficient (ADC) values on DWI, and the histopathological differentiation of HCC were analysed...
January 19, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28109133/the-prognostic-and-therapeutic-application-of-micrornas-in-breast-cancer-tissue-and-circulating-micrornas
#11
REVIEW
Afsane Bahrami, Seyed Amir Aledavoud, Kazem Anvari, Seyed Mahdi Hassanian, Mina Maftouh, Ali Yaghobzade, Omid Salarzaee, Soodabeh ShahidSales, Amir Avan
Breast cancer is the second most common malignancy diagnosed in women, supporting the need for identification of novel prognostic and diagnostic biomarkers. Recently, microRNAs have emerged as molecular regulators that can have key roles in pathogenesis and progression of different malignancies, including breast cancer. Micro-RNAs can be circulated in body fluid, suggesting their values as non-invasive marker. There is growing body of evidence showing the aberrant activation of some known circulating miRNAs, e...
January 21, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28109006/attitudes-towards-non-invasive-prenatal-diagnosis-among-obstetricians-in-pakistan-a-developing-islamic-country
#12
Shenaz Ahmed, Hussain Jafri, Yasmin Rashid, Gerald Mason, Yasmin Ehsan, Mushtaq Ahmed
OBJECTIVES: Stakeholders' views are essential for informing implementation strategies for non-invasive prenatal testing (NIPT). Little is known about such views in developing countries. We explored attitudes toward NIPT among obstetricians in Pakistan, a developing Islamic country. METHODS: A 35-item questionnaire was distributed and collected at eight events (a national conference and seven workshops in five cities) for obstetric professionals on advances in fetal medicine...
January 20, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/28108755/measurement-of-aortic-valve-coaptation-and-effective-height-using-echocardiography-in-patients-with-ventricular-septal-defects-and-aortic-valve-prolapse
#13
Satoru Iwashima, Hiroki Uchiyama, Takamichi Ishikawa, Kiyohiro Takigiku, Ken Takahashi, Manatomo Toyono, Nao Inoue, Masaki Nii
Decreased coaptation height in adults has been identified as a marker of early valve failure. We evaluated aortic valve coaptation and effective height in healthy children and in children with a ventricular septal defect (VSD) with aortic cusp prolapse (ACP), using echocardiography. We included 45 subjects with VSD with ACP, 27 did not develop aortic regurgitation (AR) by ACP and 18 developed AR by ACP, and 83 healthy children as controls. Aortic root anatomy was estimated using the parasternal long-axis view...
January 21, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28108468/metabolic-biomarker-signature-to-differentiate-pancreatic-ductal-adenocarcinoma-from-chronic-pancreatitis
#14
Julia Mayerle, Holger Kalthoff, Regina Reszka, Beate Kamlage, Erik Peter, Bodo Schniewind, Sandra González Maldonado, Christian Pilarsky, Claus-Dieter Heidecke, Philipp Schatz, Marius Distler, Jonas A Scheiber, Ujjwal M Mahajan, F Ulrich Weiss, Robert Grützmann, Markus M Lerch
OBJECTIVE: Current non-invasive diagnostic tests can distinguish between pancreatic cancer (pancreatic ductal adenocarcinoma (PDAC)) and chronic pancreatitis (CP) in only about two thirds of patients. We have searched for blood-derived metabolite biomarkers for this diagnostic purpose. DESIGN: For a case-control study in three tertiary referral centres, 914 subjects were prospectively recruited with PDAC (n=271), CP (n=282), liver cirrhosis (n=100) or healthy as well as non-pancreatic disease controls (n=261) in three consecutive studies...
January 20, 2017: Gut
https://www.readbyqxmd.com/read/28107963/chromatographic-fingerprinting-as-a-strategy-to-identify-regulated-plants-in-illegal-herbal-supplements
#15
D Custers, N Van Praag, P Courselle, S Apers, E Deconinck
Erectile dysfunction (ED) is a sexual disorder characterized by the inability to achieve or maintain a sufficiently rigid erection. Despite the availability of non-invasive oral treatment options, many patients turn to herbal alternatives. Furthermore, herbal supplements are increasingly gaining popularity in industrialized countries and, as a consequence, quality control is a highly important issue. Unfortunately, this is not a simple task since plants are often crushed and mixed with other plants, which complicates their identification by usage of classical approaches such as microscopy...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/28107807/continuous-theta-burst-stimulation-may-improve-visuospatial-neglect-via-modulating-the-attention-network-a-randomized-controlled-study
#16
Wei Fu, Lei Cao, Yanming Zhang, Su Huo, JuBao Du, Lin Zhu, Weiqun Song
BACKGROUND: Visuospatial neglect (VSN) is devastating and common after stroke, and is thought to involve functional disturbance of the attention network. Non-invasive theta-burst stimulation (TBS) may help restore the normal function of attention network, therefore facilitating recovery from VSN. OBJECTIVE: This study investigated the effects of continuous TBS on resting-state functional connectivity (RSFC) in the attention network, and behavioral performances of patients with VSN after stroke...
January 20, 2017: Topics in Stroke Rehabilitation
https://www.readbyqxmd.com/read/28107690/time-domain-nmr-as-a-new-process-monitoring-method-for-characterization-of-pharmaceutical-hydrates
#17
Stefanie Ulrike Schumacher, Benno Rothenhäusler, Alf Willmann, Jürgen Thun, Regina Moog, Martin Kuentz
Hydrates are of great pharmaceutical relevance and even though they have been characterized thoroughly by various analytical techniques, there is barely literature available on molecular mobility of the hydrate water studied by NMR relaxation in the time domain. The aim of this work was to examine the possibility of differentiating hydration states of drugs by (1)H time domain NMR (TD-NMR) regarding spin-spin and spin-lattice relaxation times (T2 and T1) using benchtop equipment. Caffeine and theophylline were selected as model compounds and binary mixtures of hydrate to anhydrate were analyzed for each drug using a spin echo and inversion recovery pulse sequence...
January 9, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28107684/non-invasive-brain-stimulation-targeting-the-right-fusiform-gyrus-selectively-increases-working-memory-for-faces
#18
Tad T Brunyé, Joseph M Moran, Amanda Holmes, Caroline R Mahoney, Holly A Taylor
The human extrastriate cortex contains a region critically involved in face detection and memory, the right fusiform gyrus. The present study evaluated whether transcranial direct current stimulation (tDCS) targeting this anatomical region would selectively influence memory for faces versus non-face objects (houses). Anodal tDCS targeted the right fusiform gyrus (Brodmann's Area 37), with the anode at electrode site PO10, and cathode at FP2. Two stimulation conditions were compared in a repeated-measures design: 0...
January 17, 2017: Brain and Cognition
https://www.readbyqxmd.com/read/28107623/dna-advanced-glycation-end-products-dna-ages-are-elevated-in-urine-and-tissue-in-an-animal-model-of-type-2-diabetes
#19
Richard Jaramillo, Sarah C Shuck, Yin S Chan, Xueli Liu, Steven E Bates, Punnajit P Lim, Daniel Tamae, Sandrine Lacoste, Timothy R O'Connor, John Stephen Termini
More precise identification and treatment monitoring of prediabetic/diabetic individuals will require additional biomarkers to complement existing diagnostic tests. Candidates include hyperglycemia-induced adducts such as advanced glycation end products (AGEs) of proteins, lipids, and DNA. The potential for DNA-AGEs as diabetic biomarkers was examined in a longitudinal study using the Leprdb/db animal model of metabolic syndrome. The DNA-AGE, N2-(1-carboxyethyl)-2´-deoxyguanosine (CEdG) was quantified by mass spectrometry using isotope dilution from urine and tissue of hyperglycemic and normoglycemic mice...
January 20, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28107576/non-invasive-anaesthetic-methods-for-dermatological-laser-procedures-a-systematic-review
#20
REVIEW
K Greveling, E P Prens, L Liu, M B A van Doorn
Pain is a common side-effect of dermatological laser procedures. Non-invasive anaesthetic drugs and anaesthetic procedures can be used to provide pain relief and increase patient satisfaction and treatment efficacy. However, it remains unclear which method provides the best pain relief. The objective of this systematic review was therefore to assess the efficacy and safety of non-invasive anaesthetic methods during dermatological laser procedures. A systematic literature search was conducted. Randomized and non-randomized controlled clinical trials (RCTs and CCTs) were included...
January 20, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
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