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https://www.readbyqxmd.com/read/28934794/effects-of-epidemiological-factors-and-pressure-pain-measurements-in-predicting-postoperative-pain-a-prospective-survey-of-1-002-chinese-patients
#1
Guangyou Duan, Shanna Guo, Yuhao Zhang, Ying Ying, Penghao Huang, Li Zhang, Xianwei Zhang
BACKGROUND: A high degree of inter-individual differences was noted in human basal pain as well as the reporting of clinical pain, such as postoperative pain. Understanding the effects of common epidemiological variations and preoperative experimental methods of human pain perception may contribute to individualized pain treatment for patients. OBJECTIVES: The current study was aimed to assess the role of epidemiological factors and preoperative experimental pain sensitivity for predicting postoperative pain and to analyze the potential effects of epidemiological factors on experimental pain sensitivity...
September 2017: Pain Physician
https://www.readbyqxmd.com/read/28934791/a-practical-guide-for-treatment-of-pain-in-patients-with-systemic-mast-cell-activation-disease
#2
Stefan Wirz, Gerhard J Molderings
Systemic mast cell activation disease (MCAD, a subclass of mastocytosis), which has a prevalence of around 17% (at least in the German population), is characterized by accumulation of genetically altered dysfunctional mast cells with abnormal release of these cells' mediators. Since mast cells affect functions in potentially every organ system, often without causing abnormalities in routine laboratory or radiologic testing, this disease has to be considered routinely in the differential diagnosis of patients with chronic multisystem polymorbidity of a generally inflammatory and allergic theme...
September 2017: Pain Physician
https://www.readbyqxmd.com/read/28934771/stimulating-the-clinical-academics-of-tomorrow-a-survey-of-research-opportunities-for-medical-students-in-new-zealand
#3
Ibrahim S Al-Busaidi, Cameron I Wells
Developing the clinical academic workforce of the future is a priority of international relevance. Despite a number of measures implemented to address this challenge, a small proportion of medical students engage in research. Lack of knowledge of available research opportunities, and difficulty finding projects and suitable mentors are key barriers to undergraduate medical research. To date, there is no consolidated source of information on undergraduate research training opportunities and their outcomes available to medical students in New Zealand...
September 22, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28934687/the-role-of-thiocyanate-in-enhancing-the-process-of-sulfite-reducing-cr-vi-by-inhibiting-the-formation-of-reactive-oxygen-species
#4
Bo Jiang, Shuaishuai Xin, Yijie Liu, Haihong He, Lin Li, Yizhen Tang, Siyi Luo, Xuejun Bi
The reductive detoxification of Cr(VI) by sulfite is known as the prevailing strategy and can be successfully implemented for the treatment of Cr(VI)-contaminated waters. However, this method inevitably faces the challenges of excessive consumption of sulfite due to the generations of highly oxidative OH and SO4(-) during the process of sulfite reducing Cr(VI). In this study, we find that a small quantity of thiocyanate (SCN) can catalytically enhance the process efficiency of Cr(VI) reduction by sulfite and effectively prevent the excessive consumption of sulfite...
September 12, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28934641/graph-construction-using-adaptive-local-hybrid-coding-scheme
#5
Fadi Dornaika, Mahdi Tavassoli Kejani, Alireza Bosaghzadeh
It is well known that dense coding with local bases (via Least Square coding schemes) can lead to large quantization errors or poor performances of machine learning tasks. On the other hand, sparse coding focuses on accurate representation without taking into account data locality due to its tendency to ignore the intrinsic structure hidden among the data. Local Hybrid Coding (LHC) (Xiang et al., 2014) was recently proposed as an alternative to the sparse coding scheme that is used in Sparse Representation Classifier (SRC)...
August 24, 2017: Neural Networks: the Official Journal of the International Neural Network Society
https://www.readbyqxmd.com/read/28934614/development-of-mother-infant-interaction-in-tickling-play-the-relationship-between-infants-ticklishness-and-social-behaviors
#6
Konomi Ishijima, Koichi Negayama
This study examined the development of mother-infant tickling interaction and the relationship between infants' ticklishness and social behaviors including infants' looking at mothers' face, mothers' narrative tickling, and mothers' laughter. Twenty-two Japanese infants aged 5 months (n=10, five girls) and 7 months (n=12, four girls) and their mothers were videotaped. Results revealed that the mothers' narrative tickling was more frequent at 7 than at 5 months and the infants' strong ticklishness showed the same tendency...
September 18, 2017: Infant Behavior & Development
https://www.readbyqxmd.com/read/28934403/improving-inpatient-medication-adherence-using-attendant-education-in-a-tertiary-care-hospital-in-uganda
#7
Patricia Alupo, Richard Ssekitoleko, Tracy Rabin, Robert Kalyesubula, Ivan Kimuli, Benjamin E Bodnar
Quality problem: Although widely utilized in resource-rich health care systems, the use of quality improvement (QI) techniques is less common in resource-limited environments. Uganda is a resource-limited country in Sub-Saharan Africa that faces many challenges with health care delivery. These challenges include understaffing, inconsistent drug availability and inefficient systems that limit the provision of clinical care. Initial assessment: Poor adherence to prescribed inpatient medications was identified as a key shortcoming of clinical care on the internal medicine wards of Mulago National Referral Hospital, Kampala, Uganda...
August 1, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/28934384/short-syndrome-due-to-a-novel-de-novo-mutation-in-prkce-protein-kinase-c%C3%A9-impairing-torc2-dependent-akt-activation
#8
Diana Alcantara, Frances Elmslie, Martine Tetreault, Eric Bareke, Taila Hartley, Jacek Majewski, Kym Boycott, A Micheil Innes, David A Dyment, Mark O'Driscoll
SHORT syndrome is a rare, recognizable syndrome resulting from heterozygous mutations in PIK3R1 encoding a regulatory subunit of phosphoinositide-3-kinase (PI3K). The condition is characterized by short stature, intrauterine growth restriction, lipoatrophy and a facial gestalt involving a triangular face, deep set eyes, low hanging columella and small chin. PIK3R1 mutations in SHORT syndrome result in reduced signaling through the PI3K-AKT-mTOR pathway. We performed whole exome sequencing for an individual with clinical features of SHORT syndrome but negative for PIK3R1 mutation and her parents...
October 1, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28934147/effects-of-precipitant-and-ph-on-coprecipitation-of-nanosized-co-cr-v-alloy-powders
#9
Xiaoyu Chen, Yongxia Li, Lan Huang, Dan Zou, Enxi Wu, Yanjun Liu, Yuanyan Xie, Rui Yao, Songyi Liao, Guangrong Wang, Feng Zheng
Nanosized Co-Cr-V alloy powders were synthesized via coprecipitation method. Effects of precipitants ((NH₄)₂C₂O₄·H₂O and Na₂CO₃) and pH were investigated by X-ray diffraction (XRD), Zeta potential analyzer, thermogravimetry-differential scanning calorimetry (TG-DSC), inductively coupled plasma-atomic emission spectrometry (ICP-AES) and scanning electron microscopy (SEM). Co-Cr-V alloy powders were consisted of major face-centered cubic Co (fcc Co) and minor hexagonal close-packed Co (hcp Co)...
September 21, 2017: Materials
https://www.readbyqxmd.com/read/28934039/social-media-and-teaching-learning-connecting-or-distancing
#10
Nan Russell Yancey
As new ideas and new ways of connecting seemingly surface ever more quickly, faculty face the daunting task of using emerging technology in the teaching-learning endeavor while honoring the presence of teacher with learner. The focus of this column is on using social media as a teaching-learning tool in the shared journey of coming to know, which is so essential for the aspiring nurse. While opportunities for using teaching-learning technologies abound and are ever-changing, faculty are challenged to cocreate a learner-focused journey of coming to know, without allowing the technology to become the focus...
October 2017: Nursing Science Quarterly
https://www.readbyqxmd.com/read/28934013/reconciling-conflicting-models-for-global-control-of-cell-cycle-transcription
#11
Chun-Yi Cho, Francis C Motta, Christina M Kelliher, Anastasia Deckard, Steven B Haase
Models for the control of global cell-cycle transcription have advanced from a CDK-APC/C oscillator, a transcription factor (TF) network, to coupled CDK-APC/C and TF networks. Nonetheless, current models were challenged by a recent study that concluded that the cell-cycle transcriptional program is primarily controlled by a CDK-APC/C oscillator in budding yeast. Here we report an analysis of the transcriptome dynamics in cyclin mutant cells that were not queried in the previous study. We find that B-cyclin oscillation is not essential for control of phase-specific transcription...
September 21, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28933923/propagandizing-the-healthy-bolshevik-life-in-the-early-ussr
#12
Tricia A Starks
This essay outlines the problems facing Soviet health authorities at the inception of the People's Commissariat of Public Health in 1918 and the innovative methods employed in sanitary enlightenment propaganda in Russia throughout the 1920s. Beset by funding issues and supply problems, the emissaries of health chose the cheapest means of health improvement (propaganda) with the most cost-effective method (prevention), and crowed of great successes even as large portions of the nation still suffered from lack of contact with sanitary authorities...
September 21, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28933912/more-is-less-learning-but-not-relaxing-buffers-deviance-under-job-stressors
#13
Chen Zhang, David M Mayer, Eunbit Hwang
Workplace deviance harms the well-being of an organization and its members. Unfortunately, theory and prior research suggest that deviance is associated with job stressors, which are endemic to work organizations and often cannot be easily eliminated. To address this conundrum, we explore actions individuals can take at work that serve as buffering conditions for the positive relationship between job stressors and deviant behavior. Drawing upon conservation of resources theory, we examine a resource-building activity (i...
September 21, 2017: Journal of Applied Psychology
https://www.readbyqxmd.com/read/28933795/microfluidic-production-of-nanoscale-perfluorocarbon-droplets-as-liquid-contrast-agents-for-ultrasound-imaging
#14
Xiaonan Xu, Ruyuan Song, Minghao He, Chuan Peng, Miao Yu, Youmin Hou, Huihe Qiu, Ruhai Zou, Shuhuai Yao
Liquid perfluorocarbon (PFC) nanodroplets may have a better chance to extravasate through inter-endothelial gaps (400-800 nm) into tumor interstitium for extravascular imaging, which holds promise as an innovative strategy for imaging-guided drug delivery, early diagnosis of cancer and minimally invasive treatment of cancer. Currently available emulsion technologies still face challenges in reducing droplet sizes from the microscale to the nanoscale. To control size and ensure monodispersity of PFC nanodroplets, we developed a flame-shaped glass capillary and polydimethylsiloxane (PDMS) hybrid device that creates a concentric flow of the dispersed phase enclosed by the focusing continuous phase at the cross-junction...
September 21, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28933752/graphene-field-effect-transistors-for-biomedical-applications-current-status-and-future-prospects
#15
REVIEW
Rhiannan Forsyth, Anitha Devadoss, Owen J Guy
Since the discovery of the two-dimensional (2D) carbon material, graphene, just over a decade ago, the development of graphene-based field effect transistors (G-FETs) has become a widely researched area, particularly for use in point-of-care biomedical applications. G-FETs are particularly attractive as next generation bioelectronics due to their mass-scalability and low cost of the technology's manufacture. Furthermore, G-FETs offer the potential to complete label-free, rapid, and highly sensitive analysis coupled with a high sample throughput...
July 26, 2017: Diagnostics
https://www.readbyqxmd.com/read/28933454/robotic-assisted-left-upper-lobectomy-facing-the-challenge-head-on
#16
EDITORIAL
Simon R Turner, Daniela Molena
No abstract text is available yet for this article.
August 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28933295/applications-of-multi-target-computer-aided-methodologies-in-molecular-design-of-cns-drugs
#17
Oleg A Raevsky, Azat Mukhametov, Veniamin Y Grigorev, Alexey Ustyugov, Shwu-Chen Tsay, Reuben Jih-Ru Hwu, Nagendra Sastry Yarla, George E Barreto, Gjumrakch Aliev, Sergey O Bachurin
: Discovery of drugs for diseases of the central nervous system (CNS) faces high attrition rates in clinical trials. Neural diseases are extremely complex in nature and typically associated with multiple drug targets. A conception of multi-target directed ligands (MTDL), widely applied to discovery of cancer pharmaceuticals, may be a perspective solution for CNS diseases. Special bio-informatics approaches have been developed which can assist the medicinal chemists in identification and structural optimization of MTDL...
September 20, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28933251/population-metrics-for-suicide-events-a-causal-inference-approach
#18
Hua He, Naiji Lu, Brady Stephens, Yinglin Xia, Robert M Bossarte, Cathleen P Kane, Wan Tang, Xin M Tu
Large-scale public health prevention initiatives and interventions are a very important component to current public health strategies. But evaluating effects of such large-scale prevention/intervention faces a lot of challenges due to confounding effects and heterogeneity of study population. In this paper, we will develop metrics to assess the risk for suicide events based on causal inference framework when the study population is heterogeneous. The proposed metrics deal with the confounding effect by first estimating the risk of suicide events within each of the risk levels, number of prior attempts, and then taking a weighted sum of the conditional probabilities...
January 1, 2017: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/28933105/-nrf2-nf-%C3%AE%C2%BAb-pathway-axes-epigenetic-regulation-and-traditional-chinese-medicine-natural-medicine-to-treat-type-2-diabetes
#19
REVIEW
Chun-Mei Zhai, Bo-Yu Jia, Zhi-Bin Wang, Xue Huai, Zhi-Chao Ma, Zhen-Kun Tian, Yong-Hai Meng
Diabetes mellitus is a characterized by high blood sugar metabolic disease, is a lifelong disease with a high incidence of major hazards. Prevention and treatment of diabetes and its complications has become a serious challenge and arduous task facing the world pharmaceutical researchers. Oxidative stress, Nfr2-NF-κB signaling axis related epigenomic genes have the apparent close relationship with type 2 diabetes,those have become one of the key focus and effective way to explore its pathogenesis, mechanism and drug screening...
December 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28933090/-comparative-studies-on-hplc-fingerprint-and-near-infrared-spectra-of-cultivated-and-reference-crude-scutellaria-baicalensis
#20
Jian-Jun Zhao, Xiao-Juan Gao, Ying-Hua Wang, Ling Ma, Han-Qing Wang
Scutellaria baicalensis is a common and important medicinal plant in China, facing with reducing sharply in wild resources. To meet the needs in Chinese herbwouls medicine market and clinical application, S. baicalensis has been widely cultivated in Ningxia, Hebei, Shanxi, and Gansu et al. HPLC finger-print and near-infrared were studied in the research to evaluate quality difference of S. baicalensis in four districts. The results showed that the similarity of HPLC finger-print of 12 cultivated S. baicalensis and reference crude herb is more than 0...
November 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
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