Panagiotis Fotiadis, Sanneke van Rooden, Jeroen van der Grond, Aaron Schultz, Sergi Martinez-Ramirez, Eitan Auriel, Yael Reijmer, Anna M van Opstal, Alison Ayres, Kristin M Schwab, Trey Hedden, Jonathan Rosand, Anand Viswanathan, Marieke Wermer, Gisela Terwindt, Reisa A Sperling, Jonathan R Polimeni, Keith A Johnson, Mark A van Buchem, Steven M Greenberg, M Edip Gurol
BACKGROUND: Loss of cortical grey matter is a diagnostic marker of many neurodegenerative diseases, and is a key mediator of cognitive impairment. We postulated that cerebral amyloid angiopathy (CAA), characterised by cortical vascular amyloid deposits, is associated with cortical tissue loss independent of parenchymal Alzheimer's disease pathology. We tested this hypothesis in patients with hereditary cerebral haemorrhage with amyloidosis-Dutch type (HCHWA-D), a monogenetic disease with minimal or no concomitant Alzheimer's disease pathology, as well as in patients with sporadic CAA and healthy and Alzheimer's disease controls...
July 2016: Lancet Neurology