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https://www.readbyqxmd.com/read/28101913/nasopharyngeal-colonization-with-streptococcus%C3%A2-pneumoniae-triggers-dendritic-cell-dependent-antibody-responses-against-invasive-disease-in-mice
#1
Anne Dommaschk, Nadine Ding, Meritxell Tort Tarres, Lara F Bittersohl, Regina Maus, Jennifer Stolper, Danny Jonigk, Peter Braubach, Torsten Lippmann, Tobias Welte, Ulrich A Maus
Nasopharyngeal colonization with Streptococcus pneumoniae (Spn) is an important precondition for the development of pneumococcal pneumonia. At the same time, nasopharyngeal colonization with Spn has been shown to mount adaptive immune responses against Spn in mice and humans. Cellular responses of the nasopharyngeal compartment, including the nasal-associated lymphoid tissue (NALT), to pneumococcal colonization and their importance for developing adaptive immune responses are poorly defined. We show that nasopharyngeal colonization with S...
January 19, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28060841/genomes-of-fasciola-hepatica-from-the-americas-reveal-colonization-with-neorickettsia-endobacteria-related-to-the-agents-of-potomac-horse-and-human-sennetsu-fevers
#2
Samantha N McNulty, Jose F Tort, Gabriel Rinaldi, Kerstin Fischer, Bruce A Rosa, Pablo Smircich, Santiago Fontenla, Young-Jun Choi, Rahul Tyagi, Kymberlie Hallsworth-Pepin, Victoria H Mann, Lakshmi Kammili, Patricia S Latham, Nicolas Dell'Oca, Fernanda Dominguez, Carlos Carmona, Peter U Fischer, Paul J Brindley, Makedonka Mitreva
Food borne trematodes (FBTs) are an assemblage of platyhelminth parasites transmitted through the food chain, four of which are recognized as neglected tropical diseases (NTDs). Fascioliasis stands out among the other NTDs due to its broad and significant impact on both human and animal health, as Fasciola sp., are also considered major pathogens of domestic ruminants. Here we present a reference genome sequence of the common liver fluke, Fasciola hepatica isolated from sheep, complementing previously reported isolate from cattle...
January 6, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28017813/association-between-state-medical-malpractice-environment-and-postoperative-outcomes-in-the-united-states
#3
Christina A Minami, Catherine R Sheils, Emily Pavey, Jeanette W Chung, Jonah J Stulberg, David D Odell, Anthony D Yang, David J Bentrem, Karl Y Bilimoria
BACKGROUND: The U.S. medical malpractice system assumes that the threat of liability should deter negligence but it is unclear whether malpractice environment impacts healthcare quality. We thus sought to explore the association between state malpractice environment and post-operative complication rates. STUDY DESIGN: This observational study included Medicare fee-for-service beneficiaries undergoing one of the following surgeries in 2010: colorectal, lung, esophageal, or pancreatic resection, total knee arthroplasty, craniotomy, gastric bypass, abdominal aortic aneurysm repair, coronary artery bypass grafting, or cystectomy...
December 22, 2016: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28011159/the-impact-of-state-tort-reforms-on-imaging-utilization
#4
Suhui Li, Avi Dors, Darwyyn Deyo, Danny R Hughes
PURPOSE: Defensive medicine, broadly defined as medical practices that protect physicians from malpractice lawsuits without providing benefits to patients, can lead to wasteful use of health care resources and higher cost. Although physicians cite malpractice liability as an important factor driving their decisions to order imaging tests, little research has been done to examine the systematic impact of liability pressure on overall imaging. The authors examined the extent to which radiography use is influenced by malpractice liability pressure among office-based physicians...
December 20, 2016: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28009242/an-analysis-of-malpractice-litigation-related-to-the-management-of-brain-aneurysms
#5
Raghav Gupta, Christoph J Griessenauer, Justin M Moore, Nimer Adeeb, Apar S Patel, Christopher S Ogilvy, Ajith J Thomas
OBJECTIVE Given the highly complex and demanding clinical environment in which neurosurgeons operate, the probability of facing a medical malpractice claim is high. Recent emphasis on tort reform within the political sphere has brought this issue to the forefront of medical literature. Despite the widespread fear of litigation in the medical community, few studies have provided an analysis of malpractice litigation in the field. Here, the authors attempt to delineate the medicolegal factors that impel plaintiffs to file medical malpractice claims related to the management of brain aneurysms, and to better characterize the nature of these lawsuits...
December 23, 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27982564/pump-and-valve-free-flow-injection-capillary-liquid-electrode-discharge-optical-emission-spectrometry-coupled-to-a-droplet-array-platform
#6
Anqin Leng, Yao Lin, Yunfei Tian, Li Wu, Xiaoming Jiang, Xiandeng Hou, Chengbin Zheng
A miniature (2.5 cm length × 2.0 cm width × 1.0 cm height), low power (<10 W), and capillary liquid electrode microplasma optical emission spectrometer was developed for rapid determination of metallic species in aqueous solutions. The sample solution can be automatically introduced into the source without a pump owing to the inherent capillary attraction and the force arising from the solution vaporization induced by microplasma. A droplet array was used as a sampling platform to realize flow injection without using any valve and pump, significantly increasing throughput to 90 samples h(-1)...
December 16, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27940755/lysine-restriction-and-pyridoxal-phosphate-administration-in-a-nadk2-patient
#7
Frederic Tort, Olatz Ugarteburu, Maria Angeles Torres, Judit García-Villoria, Marisa Girós, Angeles Ruiz, Antonia Ribes
We report the case of a 10-year-old Spanish girl with mutations in NADK2 Prenatal central nervous system abnormalities showed ventriculomegaly, colpocephaly, and hypoplasia of the corpus callosum. At birth, axial hypotonia, uncoordinated movements, microcephaly, and generalized cerebellar atrophy were detected. Metabolic investigations revealed high lysine, lactate, and pipecolic acid levels in blood and cerebrospinal fluid. Pyruvate carboxylase and pyruvate dehydrogenase activity in fibroblasts were normal...
November 2016: Pediatrics
https://www.readbyqxmd.com/read/27925581/on-cross-frequency-phase-phase-coupling-between-theta-and-gamma-oscillations-in-the-hippocampus
#8
Robson Scheffer-Teixeira, Adriano Bl Tort
Phase-amplitude coupling between theta and multiple gamma sub-bands is a hallmark of hippocampal activity and believed to take part in information routing. More recently, theta and gamma oscillations were also reported to exhibit phase-phase coupling, or n:m phase-locking, suggesting an important mechanism of neuronal coding that has long received theoretical support. However, by analyzing simulated and actual LFPs, here we question the existence of theta-gamma phase-phase coupling in the rat hippocampus. We show that the quasi-linear phase shifts introduced by filtering lead to spurious coupling levels in both white noise and hippocampal LFPs, which highly depend on epoch length, and that significant coupling may be falsely detected when employing improper surrogate methods...
December 7, 2016: ELife
https://www.readbyqxmd.com/read/27923071/c-type-lectin-mincle-recognizes-glucosyl-diacylglycerol-of-streptococcus-pneumoniae-and-plays-a-protective-role-in-pneumococcal-pneumonia
#9
Friederike Behler-Janbeck, Tomotsugu Takano, Regina Maus, Jennifer Stolper, Danny Jonigk, Meritxell Tort Tarrés, Thomas Fuehner, Antje Prasse, Tobias Welte, Mattie S M Timmer, Bridget L Stocker, Yoichi Nakanishi, Tomofumi Miyamoto, Sho Yamasaki, Ulrich A Maus
Among various innate immune receptor families, the role of C-type lectin receptors (CLRs) in lung protective immunity against Streptococcus pneumoniae (S. pneumoniae) is not fully defined. We here show that Mincle gene expression was induced in alveolar macrophages and neutrophils in bronchoalveolar lavage fluids of mice and patients with pneumococcal pneumonia. Moreover, S. pneumoniae directly triggered Mincle reporter cell activation in vitro via its glycolipid glucosyl-diacylglycerol (Glc-DAG), which was identified as the ligand recognized by Mincle...
December 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27916363/tipping-the-scales-educating-surgeons-about-medical-malpractice
#10
Steven E Raper, Johncy Joseph, Wilda G Seymour, Patricia G Sullivan
BACKGROUND: In Pennsylvania, medical malpractice premiums are a major cost to surgeons. Yet surgeons often have little if any education in the basics of tort litigation or how to manage their risk. This work describes one approach for educating academic faculty surgeons on current concepts of medical malpractice and provide some guidance on how to "tip the scales of justice"; or minimize the risks of being named in a malpractice claim. MATERIALS AND METHODS: The course had five parts: the basics of medical malpractice, the cost of malpractice insurance, current departmental claims experience, strategies for decreasing the risk of being named in a claim, and an overview of malpractice reforms...
November 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27884553/atlas-of-systematic-variation-in-renal-replacement-therapy-in-catalonia-2002-2012
#11
Cristian Tebé Condomí, Emma Arcos, Jordi Comas, Mireia Espallargues, Joan M V Pons, Joan M Díaz, Jaume Tort, Alberto Martinez-Castelao
INTRODUCTION: Variations in the use of healthcare services can be defined as systematic variations of adjusted rates for certain aggregation levels of the population. The study analyses how renal replacement therapy (RRT) is used, identifying RRT variability in Catalonia from 2002 to 2012. MATERIAL AND METHODS: Ecological study by health area using data from the Catalan renal registry. We present incident rates, standardised incidence ratios and prevalence, while variability was calculated through direct and indirect standardisation methods...
November 21, 2016: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/27873571/the-determinants-of-defensive-medicine-practices-in-belgium
#12
Tom Vandersteegen, Wim Marneffe, Irina Cleemput, Dominique Vandijck, Lode Vereeck
In 2010 the Belgian government introduced a low cost administrative procedure for compensating medical injuries to overcome the major shortcomings of the existing tort system. This paper examines, for the first time, to what extent this reform had an impact on physician specialists' defensive practices and what are the relevant determinants affecting physicians' clinical decision making. Based on a survey of 508 physicians, we find evidence of a relatively modest increase in defensive practices among physicians in various specialties...
November 22, 2016: Health Economics, Policy, and Law
https://www.readbyqxmd.com/read/27866079/multimodal-plasmonic-biosensing-nanostructures-prepared-by-dna-directed-immobilization-of-multifunctional-dna-gold-nanoparticles
#13
Nuria Tort, J-Pablo Salvador, M-Pilar Marco
Biofunctional multimodal plasmonic nanostructures suitable for multiplexed localized surface plasmon resonance (LSPR) biosensing have been created by DNA-directed immobilization (DDI) of two distinct multifunctional biohybrid gold nanoparticles. Gold nanoparticles (AuNP) of distinct sizes, and therefore showing distinct plasmon resonant peaks (RP), have been biofunctionalized and codified with two different single stranded-DNA (ssDNA) chains. One of these oligonucleotide chains has been specifically designed to direct each AuNP to a distinct location of the surface of a DNA microarray chip through specific hybridization with complementary oligonucleotide strands...
April 15, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27862579/mutations-in-trappc11-are-associated-with-a-congenital-disorder-of-glycosylation
#14
Leslie Matalonga, Miren Bravo, Carla Serra-Peinado, Elisabeth García-Pelegrí, Olatz Ugarteburu, Silvia Vidal, Maria Llambrich, Ester Quintana, Pedro Fuster-Jorge, Maria Nieves Gonzalez-Bravo, Sergi Beltran, Joaquin Dopazo, Francisco Garcia-Garcia, François Foulquier, Gert Matthijs, Philippa Mills, Antonia Ribes, Gustavo Egea, Paz Briones, Frederic Tort, Marisa Girós
Congenital disorders of glycosylation (CDG) are a heterogeneous and rapidly growing group of diseases caused by abnormal glycosylation of proteins and/or lipids. Mutations in genes involved in the homeostasis of the endoplasmic reticulum (ER), the Golgi apparatus (GA), and the vesicular trafficking from the ER to the ER-Golgi intermediate compartment (ERGIC) have been found to be associated with CDG. Here, we report a patient with defects in both N- and O-glycosylation combined with a delayed vesicular transport in the GA due to mutations in TRAPPC11, a subunit of the TRAPPIII complex...
February 2017: Human Mutation
https://www.readbyqxmd.com/read/27836091/initial-management-of-postpartum-hemorrhage-a-cohort-study-in-benin-and-mali
#15
Julie Tort, Mamadou Traoré, Benjamin Hounkpatin, Cécile Bodin, Patrick Rozenberg, Alexandre Dumont
OBJECTIVE: To determine the components of initial management associated with a decreased risk of severe postpartum hemorrhage (PPH) in Benin and Mali. METHODS: A cohort study was conducted between May 2013 and September 2014 that included all women who delivered vaginally in seven participating centers and who presented excessive bleeding after birth. Severe PPH was defined as PPH that required surgical treatment (vascular ligature and/or hysterectomy), and/or blood transfusion, and/or transfer to an intensive care unit, and/or an outcome of maternal death...
November 2016: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/27813058/resolving-malpractice-claims-after-tort-reform-experience-in-a-self-insured-texas-public-academic-health-system
#16
William M Sage, Molly Colvard Harding, Eric J Thomas
OBJECTIVE: To describe the litigation experience in a state with strict tort reform of a large public university health system that has committed to transparency with patients and families in resolving medical errors. DATA SOURCES/STUDY SETTING: Secondary data collected from The University of Texas System, which self-insures approximately 6,000 physicians at six health campuses across the state. We obtained internal case management data for all medical malpractice claims closed during 1 year before and 6 recent years following the enactment of state tort reform legislation...
December 2016: Health Services Research
https://www.readbyqxmd.com/read/27803267/what-s-the-rush-tort-laws-and-elective-early-term-induction-of-labor
#17
Louise Marie Roth
Tort laws aim to deter risky medical practices and increase accountability for harm. This research examines their effects on deterrence of a high-risk obstetric practice in the United States: elective early-term (37-38 weeks gestation) induction of labor. Using birth certificate data from the Natality Detail Files and state-level data from publicly available sources, this study analyzes the effects of tort laws on labor induction with multilevel models (MLM) of 665,491 early-term births nested in states. Results reveal that caps on damages are associated with significantly higher odds of early-term induction and Proportionate Liability (PL) is associated with significantly lower odds compared to Joint and Several Liability (JSL)...
November 1, 2016: Journal of Health and Social Behavior
https://www.readbyqxmd.com/read/27782969/%C3%AF-3-supplementation-in-hiv-1-infected-individuals-with-unsuppressed-viral-load-cause-for-caution
#18
Olivia Tort, Sonsoles Sánchez-Palomino, Tuixent Escribà, Carlos Calvo, Tània González, José Maria Gatell, Aleix Sala-Vila, Mireia Arnedo
No abstract text is available yet for this article.
November 13, 2016: AIDS
https://www.readbyqxmd.com/read/27774216/just-compensation-a-no-fault-proposal-for-research-related-injuries
#19
Leslie Meltzer Henry, Megan E Larkin, Elizabeth R Pike
Biomedical research, no matter how well designed and ethically conducted, carries uncertainties and exposes participants to risk of injury. Research injuries can range from the relatively minor to those that result in hospitalization, permanent disability, or even death. Participants might also suffer a range of economic harms related to their injuries. Unlike the vast majority of developed countries, which have implemented no-fault compensation systems, the United States continues to rely on the tort system to compensate injured research participants-an approach that is no longer morally defensible...
November 2015: Journal of Law and the Biosciences
https://www.readbyqxmd.com/read/27769375/species-specific-isotope-dilution-for-the-accurate-and-si-traceable-determination-of-arsenobetaine-and-methylmercury-in-cuttlefish-and-prawn
#20
Paramee Kumkrong, Benjaporn Thiensong, Phuong Mai Le, Garnet McRae, Anthony Windust, Suladda Deawtong, Juris Meija, Paulette Maxwell, Lu Yang, Zoltán Mester
Methods based on species specific isotope dilution were developed for the accurate and SI traceable determination of arsenobetaine (AsBet) and methylmercury (MeHg) in prawn and cuttlefish tissues by LC-MS/MS and SPME GC-ICPMS. Quantitation of AsBet and MeHg were achieved by using a (13)C-enriched AsBet spike (NRC CRM CBET-1) and an enriched spike of Me(198)Hg (NRC CRM EMMS-1), respectively, wherein analyte mass fractions in enriched spikes were determined by reverse isotope dilution using natural abundance AsBet and MeHg primary standards...
November 2, 2016: Analytica Chimica Acta
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