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https://www.readbyqxmd.com/read/27923071/c-type-lectin-mincle-recognizes-glucosyl-diacylglycerol-of-streptococcus-pneumoniae-and-plays-a-protective-role-in-pneumococcal-pneumonia
#1
Friederike Behler-Janbeck, Tomotsugu Takano, Regina Maus, Jennifer Stolper, Danny Jonigk, Meritxell Tort Tarrés, Thomas Fuehner, Antje Prasse, Tobias Welte, Mattie S M Timmer, Bridget L Stocker, Yoichi Nakanishi, Tomofumi Miyamoto, Sho Yamasaki, Ulrich A Maus
Among various innate immune receptor families, the role of C-type lectin receptors (CLRs) in lung protective immunity against Streptococcus pneumoniae (S. pneumoniae) is not fully defined. We here show that Mincle gene expression was induced in alveolar macrophages and neutrophils in bronchoalveolar lavage fluids of mice and patients with pneumococcal pneumonia. Moreover, S. pneumoniae directly triggered Mincle reporter cell activation in vitro via its glycolipid glucosyl-diacylglycerol (Glc-DAG), which was identified as the ligand recognized by Mincle...
December 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27916363/tipping-the-scales-educating-surgeons-about-medical-malpractice
#2
Steven E Raper, Johncy Joseph, Wilda G Seymour, Patricia G Sullivan
BACKGROUND: In Pennsylvania, medical malpractice premiums are a major cost to surgeons. Yet surgeons often have little if any education in the basics of tort litigation or how to manage their risk. This work describes one approach for educating academic faculty surgeons on current concepts of medical malpractice and provide some guidance on how to "tip the scales of justice"; or minimize the risks of being named in a malpractice claim. MATERIALS AND METHODS: The course had five parts: the basics of medical malpractice, the cost of malpractice insurance, current departmental claims experience, strategies for decreasing the risk of being named in a claim, and an overview of malpractice reforms...
November 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27884553/atlas-of-systematic-variation-in-renal-replacement-therapy-in-catalonia-2002-2012
#3
Cristian Tebé Condomí, Emma Arcos, Jordi Comas, Mireia Espallargues, Joan M V Pons, Joan M Díaz, Jaume Tort, Alberto Martinez-Castelao
INTRODUCTION: Variations in the use of healthcare services can be defined as systematic variations of adjusted rates for certain aggregation levels of the population. The study analyses how renal replacement therapy (RRT) is used, identifying RRT variability in Catalonia from 2002 to 2012. MATERIAL AND METHODS: Ecological study by health area using data from the Catalan renal registry. We present incident rates, standardised incidence ratios and prevalence, while variability was calculated through direct and indirect standardisation methods...
November 21, 2016: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/27873571/the-determinants-of-defensive-medicine-practices-in-belgium
#4
Tom Vandersteegen, Wim Marneffe, Irina Cleemput, Dominique Vandijck, Lode Vereeck
In 2010 the Belgian government introduced a low cost administrative procedure for compensating medical injuries to overcome the major shortcomings of the existing tort system. This paper examines, for the first time, to what extent this reform had an impact on physician specialists' defensive practices and what are the relevant determinants affecting physicians' clinical decision making. Based on a survey of 508 physicians, we find evidence of a relatively modest increase in defensive practices among physicians in various specialties...
November 22, 2016: Health Economics, Policy, and Law
https://www.readbyqxmd.com/read/27866079/multimodal-plasmonic-biosensing-nanostructures-prepared-by-dna-directed-immobilization-of-multifunctional-dna-gold-nanoparticles
#5
Nuria Tort, J-Pablo Salvador, M-Pilar Marco
Biofunctional multimodal plasmonic nanostructures suitable for multiplexed localized surface plasmon resonance (LSPR) biosensing have been created by DNA-directed immobilization (DDI) of two distinct multifunctional biohybrid gold nanoparticles. Gold nanoparticles (AuNP) of distinct sizes, and therefore showing distinct plasmon resonant peaks (RP), have been biofunctionalized and codified with two different single stranded-DNA (ssDNA) chains. One of these oligonucleotide chains has been specifically designed to direct each AuNP to a distinct location of the surface of a DNA microarray chip through specific hybridization with complementary oligonucleotide strands...
November 11, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27862579/mutations-in-trappc11-are-associated-with-a-congenital-disorder-of-glycosylation
#6
Leslie Matalonga, Miren Bravo, Carla Serra-Peinado, Elisabeth García-Pelegrí, Olatz Ugarteburu, Silvia Vidal, Maria Llambrich, Ester Quintana, Pedro Fuster-Jorge, Maria Nieves Gonzalez-Bravo, Sergi Beltran, Joaquin Dopazo, Francisco Garcia-Garcia, François Foulquier, Gert Matthijs, Philippa Mills, Antonia Ribes, Gustavo Egea, Paz Briones, Frederic Tort, Marisa Girós
Congenital disorders of glycosylation (CDG) are a heterogeneous and rapidly growing group of diseases caused by abnormal glycosylation of proteins and/or lipids. Mutations in genes involved in the homeostasis of the endoplasmic reticulum (ER), the Golgi apparatus (GA), and the vesicular trafficking from the ER to the ER-Golgi intermediate compartment (ERGIC) have been found to be associated with CDG. Here, we report a patient with defects in both N- and O-glycosylation combined with a delayed vesicular transport in the GA due to mutations in TRAPPC11, a subunit of the TRAPPIII complex...
November 10, 2016: Human Mutation
https://www.readbyqxmd.com/read/27836091/initial-management-of-postpartum-hemorrhage-a-cohort-study-in-benin-and-mali
#7
Julie Tort, Mamadou Traoré, Benjamin Hounkpatin, Cécile Bodin, Patrick Rozenberg, Alexandre Dumont
OBJECTIVE: To determine the components of initial management associated with a decreased risk of severe postpartum hemorrhage (PPH) in Benin and Mali. METHODS: A cohort study was conducted between May 2013 and September 2014 that included all women who delivered vaginally in seven participating centers and who presented excessive bleeding after birth. Severe PPH was defined as PPH that required surgical treatment (vascular ligature and/or hysterectomy), and/or blood transfusion, and/or transfer to an intensive care unit, and/or an outcome of maternal death...
November 2016: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/27813058/resolving-malpractice-claims-after-tort-reform-experience-in-a-self-insured-texas-public-academic-health-system
#8
William M Sage, Molly Colvard Harding, Eric J Thomas
OBJECTIVE: To describe the litigation experience in a state with strict tort reform of a large public university health system that has committed to transparency with patients and families in resolving medical errors. DATA SOURCES/STUDY SETTING: Secondary data collected from The University of Texas System, which self-insures approximately 6,000 physicians at six health campuses across the state. We obtained internal case management data for all medical malpractice claims closed during 1 year before and 6 recent years following the enactment of state tort reform legislation...
November 4, 2016: Health Services Research
https://www.readbyqxmd.com/read/27803267/what-s-the-rush-tort-laws-and-elective-early-term-induction-of-labor
#9
Louise Marie Roth
Tort laws aim to deter risky medical practices and increase accountability for harm. This research examines their effects on deterrence of a high-risk obstetric practice in the United States: elective early-term (37-38 weeks gestation) induction of labor. Using birth certificate data from the Natality Detail Files and state-level data from publicly available sources, this study analyzes the effects of tort laws on labor induction with multilevel models (MLM) of 665,491 early-term births nested in states. Results reveal that caps on damages are associated with significantly higher odds of early-term induction and Proportionate Liability (PL) is associated with significantly lower odds compared to Joint and Several Liability (JSL)...
December 2016: Journal of Health and Social Behavior
https://www.readbyqxmd.com/read/27782969/%C3%AF-3-supplementation-in-hiv-1-infected-individuals-with-unsuppressed-viral-load-cause-for-caution
#10
Olivia Tort, Sonsoles Sánchez-Palomino, Tuixent Escribà, Carlos Calvo, Tània González, José Maria Gatell, Aleix Sala-Vila, Mireia Arnedo
No abstract text is available yet for this article.
November 13, 2016: AIDS
https://www.readbyqxmd.com/read/27774216/just-compensation-a-no-fault-proposal-for-research-related-injuries
#11
Leslie Meltzer Henry, Megan E Larkin, Elizabeth R Pike
Biomedical research, no matter how well designed and ethically conducted, carries uncertainties and exposes participants to risk of injury. Research injuries can range from the relatively minor to those that result in hospitalization, permanent disability, or even death. Participants might also suffer a range of economic harms related to their injuries. Unlike the vast majority of developed countries, which have implemented no-fault compensation systems, the United States continues to rely on the tort system to compensate injured research participants-an approach that is no longer morally defensible...
November 2015: Journal of Law and the Biosciences
https://www.readbyqxmd.com/read/27769375/species-specific-isotope-dilution-for-the-accurate-and-si-traceable-determination-of-arsenobetaine-and-methylmercury-in-cuttlefish-and-prawn
#12
Paramee Kumkrong, Benjaporn Thiensong, Phuong Mai Le, Garnet McRae, Anthony Windust, Suladda Deawtong, Juris Meija, Paulette Maxwell, Lu Yang, Zoltán Mester
Methods based on species specific isotope dilution were developed for the accurate and SI traceable determination of arsenobetaine (AsBet) and methylmercury (MeHg) in prawn and cuttlefish tissues by LC-MS/MS and SPME GC-ICPMS. Quantitation of AsBet and MeHg were achieved by using a (13)C-enriched AsBet spike (NRC CRM CBET-1) and an enriched spike of Me(198)Hg (NRC CRM EMMS-1), respectively, wherein analyte mass fractions in enriched spikes were determined by reverse isotope dilution using natural abundance AsBet and MeHg primary standards...
November 2, 2016: Analytica Chimica Acta
https://www.readbyqxmd.com/read/27720101/%C3%A3-valuation-%C3%A3-chographique-des-complications-au-premier-trimestre-de-grossesse
#13
Lucie Morin, Yvonne M Cargill, Phyllis Glanc
OBJECTIFS: RéSULTATS: SOURCES DE DONNéES: Nous avons effectué des recherches dans MEDLINE et un examen de la bibliographie des articles recensés. VALEURS: Le Comité d'imagerie diagnostique de la Société des obstétriciens et gynécologues du Canada a passé en revue les données probantes recueillies. Les recommandations reposent sur les lignes directrices élaborées par le Groupe d'étude canadien sur les soins de santé préventifs (tableau 1). AVANTAGES, DéSAVANTAGES ET COûTS: Les femmes qui présentent des saignements durant le premier trimestre peuvent recevoir un diagnostic incorrect d'avortement manqué...
October 2016: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/27608827/fasciolosis-in-south-america-epidemiology-and-control-challenges
#14
C Carmona, J F Tort
Fasciolosis caused by Fasciola hepatica severely affects the efficiency of livestock production systems worldwide. In addition to the economic impact inflicted on livestock farmers, fasciolosis is an emergent zoonosis. This review emphasizes different aspects of the disease in South America. Available data on epidemiology in bovines and ovines in different countries, as well as a growing body of information on other domestic and wildlife definitive hosts, are summarized. The issue of drug resistance that compromises the long-term sustainability of current pharmacological strategies is examined from a regional perspective...
September 9, 2016: Journal of Helminthology
https://www.readbyqxmd.com/read/27586888/differential-diagnosis-of-lipoic-acid-synthesis-defects
#15
Frederic Tort, Xènia Ferrer-Cortes, Antonia Ribes
Lipoic acid (LA) is an essential cofactor required for the activity of five multienzymatic complexes that play a central role in the mitochondrial energy metabolism: four 2-oxoacid dehydrogenase complexes [pyruvate dehydrogenase (PDH), branched-chain ketoacid dehydrogenase (BCKDH), 2-ketoglutarate dehydrogenase (2-KGDH), and 2-oxoadipate dehydrogenase (2-OADH)] and the glycine cleavage system (GCS). LA is synthesized in a complex multistep process that requires appropriate function of the mitochondrial fatty acid synthesis (mtFASII) and the biogenesis of iron-sulphur (Fe-S) clusters...
November 2016: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/27579146/telemedicine-the-legal-framework-or-the-lack-of-it-in-europe
#16
Vera Lúcia Raposo
In the framework of European law telemedicine is, simultaneously, a health service and an information service, therefore, both regulations apply. In what concerns healthcare and the practice of medicine there are no uniform regulations at the European level. Concerning health services the most relevant achievement to regulate this domain is Directive 2011/24/EU. In what regards information and telecommunications we must have in consideration Directive 95/46/EU, Directive 2000/31/EC and Directive 2002/58/EC...
2016: GMS Health Technology Assessment
https://www.readbyqxmd.com/read/27578339/invisible-wounds-obstetric-violence-in-the-united-states
#17
Farah Diaz-Tello
In recent years, there has been growing public attention to a problem many US health institutions and providers disclaim: bullying and coercion of pregnant women during birth by health care personnel, known as obstetric violence. Through a series of real case studies, this article provides a legal practitioner's perspective on a systemic problem of institutionalized gender-based violence with only individual tort litigation as an avenue for redress, and even that largely out of reach for women. It provides an overview of the limitations of the civil justice system in addressing obstetric violence, and compares alternatives from Latin American jurisdictions...
May 2016: Reproductive Health Matters
https://www.readbyqxmd.com/read/27574476/no-fault-compensation-for-ventilator-dependent-children-a-reasonable-settlement-value-for-lifetime-attendant-care
#18
Randall C Jenkins, Brian W Boelens, Kari L Aasheim, Nikolaus Gravenstein
Severe neurological outcomes sustained in childhood often result in lifetime health care needs that are beyond the financial means of most families. When severe neurological deficits are alleged to have resulted from professional negligence, relief may be sought through litigation; however, the American tort system often yields inconsistent results or no compensation for patients. We sought to identify a reasonable, objective, and data-based monetary range for a no-fault compensation system with high- and low-financial limits for those with severe neurological deficits...
2016: Risk Management and Healthcare Policy
https://www.readbyqxmd.com/read/27565569/pre-vaccine-era-cervical-human-papillomavirus-infection-among-screening-population-of-women-in-west-austria
#19
Wegene Borena, Margarethe Grünberger, Andreas Widschwendter, Karl Heinz Kraxner, Elisabeth Marth, Peter Mayr, Joerg Meier, Norman Ruth, Aida Tort Guerrero, Christian Marth, Dorothee Holm-von Laer
BACKGROUND: In order to evaluate the newly implemented gender-neutral HPV vaccination program, knowledge on the pre-vaccine prevalence of HPV infection is of paramount importance. Data on HPV infection among the women with no known previous cytological abnormalities are inexistent in Austria. This study presents data on the prevalence and distribution of HPV genotypes among women with no known cytological abnormalities in west Austria. METHODS: Women between 18 and 65 years of age attending annual cervical cancer screening examinations were included in the study...
2016: BMC Public Health
https://www.readbyqxmd.com/read/27531937/health-law-2015-individuals-and-populations
#20
Peter D Jacobson, Rachel Dahlen
In this article, we assess two particular trends in judicial doctrine that are likely to emerge in the post-ACA era. The first trend is the inevitable emergence of enterprise medical liability (EML) that will supplant tort law's unstable attempt to apportion liability between physicians and institutions. Arguments favoring EML in health law date back to the early 1980s. But health care's ongoing consolidation suggests that the time has arrived for courts or state legislatures to develop legal doctrine that more closely resembles the ways in which health care is now delivered...
August 16, 2016: Journal of Health Politics, Policy and Law
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