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https://www.readbyqxmd.com/read/28314501/legal-and-regulatory-barriers-to-reverse-innovation
#1
Virginia Rowthorn, Alexander J Plum, John Zervos
BACKGROUND: Reverse innovation, or the importation of new, affordable, and efficacious models to high-income countries from the developing world, has emerged as a way to improve the health care system in the United States. Reverse innovation has been identified as a key emerging trend in global health systems in part because low-resourced settings are particularly good laboratories for low-cost/high-impact innovations that are developed out of necessity. A difficult question receiving scant attention is that of legal and regulatory barriers...
November 2016: Annals of Global Health
https://www.readbyqxmd.com/read/28276144/malpractice-reduction-and-standardization-of-care-2-sides-of-the-same-coin
#2
Steven L Clark
The tort system in the U.S. functions poorly in adjudicating blame and providing compensation for adverse medical outcomes, and the overhead costs of this system are exorbitant. (Studdert etal.NEngJMed2006;354: 2024-33) The question is whether the system can be improved within the constraints of fairness and justice to both patients and providers, and the financial realities of a broken U.S. health care system. This article is protected by copyright. All rights reserved.
March 9, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28256499/portal-venous-thrombosis-developing-after-torsion-of-a-wandering-spleen
#3
Ö Yilmaz, R Kiziltan, N Almali, A Aras
Torsion of a wandering spleen is a rare disease. The symptoms and signs of this condition are only present when the splenic pedicle torts. The etiological factors are the congenital absence of the ligaments that hold the spleen in its normal anatomic position, or the relaxation of these ligaments resulting from conditions like trauma and abdominal surgery. We aimed to present a rare case with torsion of wandering spleen that consequently developed thrombosis of portal vein and its branches, taking into consideration the relevant literature...
March 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28254407/patient-safety-and-the-malpractice-system
#4
REVIEW
James Q Swift
The cost of health care in the United States and malpractice insurance has escalated greatly over the past 30 years. In an ideal world, the goals of the tort system would be aligned with efforts at improving safety. In fact, there is little evidence that the tort system and the processes of risk management and informed consent have improved patient safety. The article explores the disunion between patient safety and the malpractice system.
February 26, 2017: Oral and Maxillofacial Surgery Clinics of North America
https://www.readbyqxmd.com/read/28252226/death-of-recipients-after-kidney-living-donation-triples-donors-risk-of-dropping-out-from-follow-up
#5
Xavier Torres, Jordi Comas, Emma Arcos, Jaume Tort, Fritz Diekmann
Although kidney transplantation from the donation of a living donor is a safe treatment for end-stage renal disease, inferences about safety of living kidney donors might be biased by an informative censoring caused by the non-inclusion of a substantial percentage of donors lost-to-follow-up. With the aim of assessing the presence of a potential informative censoring in living kidney donation outcomes of Catalan donors for a period of 12 years, 573 donors followed and lost-to-follow-up were compared. Losses of follow-up over time were also assessed by univariate and multivariate survival analysis, along with Cox regression...
March 2, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28248469/medical-malpractice-and-tort-reform
#6
Melissa D Berry, Elizabeth Polking, Robert White
No abstract text is available yet for this article.
December 27, 2016: Issue Brief of the Health Policy Tracking Service
https://www.readbyqxmd.com/read/28244608/malignant-mesothelioma-due-to-asbestos-exposure-in-dental-tape
#7
Steven B Markowitz, Jacqueline M Moline
Although most cases of malignant mesothelioma of the pleura are caused by one or more readily recognized sources of exposure to asbestos, cases of the disease with more occult exposure occur, especially since asbestos has been used in over 3,000 products. Dental lining tape contained asbestos from the 1930s until at least the 1970s and was used in the lost wax method of casting crowns, bridges, and other metal dental prosthetic devices. We report six cases of pathology-verified malignant mesothelioma, mostly among dentists, following exposure to airborne dust from asbestos dental tape, which resulted in asbestos tort litigation...
February 28, 2017: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/28239996/re-presentations-and-recurrent-events-following-initial-management-of-the-acute-paediatric-scrotum-a-5-year-review
#8
Shareena Lala, Neil Price, Vipul Upadhyay
BACKGROUND: Previous reviews report relatively low rates of post-operative complications for acute scrotal exploration. The aim of this study was to evaluate the re-presentation to hospital in boys with previous acute scrotal pathology, reviewing contralateral symptoms, post-operative complications, testicular torsion following fixation and failure of conservative management of testicular appendage (TA) torsion. METHODS: All boys under 16 years presenting to our unit with an acute scrotum from January 2008 to December 2012 (5-year period) were identified...
February 27, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28216771/filicide-in-the-united-states
#9
Phillip J Resnick
In the United States the Accreditation Council of Graduate Medical Education determines the curriculum required for fellows in forensic psychiatry to become board certified as a subspecialist. Areas that must be covered during the one year fellowship include criminal issues, such as insanity; civil issues, such as tort law and Workers' Compensation; legal regulation of psychiatry, such as confidentiality and involuntary hospitalization; and correctional psychiatry issues, such as dual agency and prisoner's rights...
December 2016: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/28169028/linking-cortisol-response-with-gene-expression-in-fish-exposed-to-gold-nanoparticles
#10
M Teles, A M V M Soares, L Tort, L Guimarães, M Oliveira
Fish exposure to environmental stressors (e.g. chemicals, hypoxia, temperature) induce responses enabling them to cope with alterations in their environment. A stress response involves a wide array of changes, from molecular to physiological and behavioural, set to counteract the effect of the stressor and recover homeostatic equilibrium. Among other processes, there is activation of the hypothalamus-pituitary-interrenal (HPI) axis, resulting in stimulation of the steroidogenic pathway and release of cortisol, important mediator of the adaptive response to stress...
April 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28165358/extending-immunological-profiling-in-the-gilthead-sea-bream-sparus-aurata-by-enriched-cdna-library-analysis-microarray-design-and-initial-studies-upon-the-inflammatory-response-to-pamps
#11
Sebastian Boltaña, Barbara Castellana, Giles Goetz, Lluis Tort, Mariana Teles, Victor Mulero, Beatriz Novoa, Antonio Figueras, Frederick W Goetz, Cristian Gallardo-Escarate, Josep V Planas, Simon Mackenzie
This study describes the development and validation of an enriched oligonucleotide-microarray platform for Sparus aurata (SAQ) to provide a platform for transcriptomic studies in this species. A transcriptome database was constructed by assembly of gilthead sea bream sequences derived from public repositories of mRNA together with reads from a large collection of expressed sequence tags (EST) from two extensive targeted cDNA libraries characterizing mRNA transcripts regulated by both bacterial and viral challenge...
February 3, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28155047/transoral-robotic-thyroidectomy-a-preclinical-feasibility-study-using-the-da-vinci-xi-platform
#12
Jonathon O Russell, Salem I Noureldine, Mai G Al Khadem, Hamad A Chaudhary, Andrew T Day, Hoon Yub Kim, Ralph P Tufano, Jeremy D Richmon
Transoral thyroid surgery allows the surgeon to conceal incisions within the oral cavity without significantly increasing the amount of required dissection. TORT provides an ideal scarless, midline access to the thyroid gland and bilateral central neck compartments. This approach, however, presents multiple technical challenges. Herein, we present our experience using the latest generation robotic surgical system to accomplish transoral robotic thyroidectomy (TORT). In two human cadavers, the da Vinci Xi surgical system (Intuitive Surgical, Sunnyvale, CA, USA) was used to complete TORT...
February 2, 2017: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/28129637/damage-caps-and-defensive-medicine-revisited
#13
Myungho Paik, Bernard Black, David A Hyman
Does tort reform reduce defensive medicine and thus healthcare spending? Several (though not all) prior studies, using a difference-in-differences (DiD) approach, find lower Medicare spending for hospital care after states adopt caps on non-economic or total damages ("damage caps"), during the "second" reform wave of the mid-1980s. We re-examine this issue in several ways. We study the nine states that adopted caps during the "third reform wave," from 2002 to 2005. We find that damage caps have no significant impact on Medicare Part A spending, but predict roughly 4% higher Medicare Part B spending...
November 14, 2016: Journal of Health Economics
https://www.readbyqxmd.com/read/28119147/cellular-and-transcriptomic-response-to-treatment-with-the-probiotic-candidate-vibrio-lentus-in-gnotobiotic-sea-bass-dicentrarchus-labrax-larvae
#14
Marlien Schaeck, Felipe E Reyes-López, Eva Vallejos-Vidal, Jolien Van Cleemput, Luc Duchateau, Wim Van den Broeck, Lluis Tort, Annemie Decostere
The present study aimed at evaluating the cellular and transcriptomic responses induced by the probiotic candidate Vibrio lentus with gnotobiotic European sea bass (Dicentrarchus labrax, Linnaeus 1785) larvae. For this, a histomorphological analysis was performed using the terminal deoxynucleotidyltransferase-mediated dUTP nick end labeling (TUNEL) and the anti-proliferating cell nuclear antigen (PCNA) assay. In addition, a global transcriptomic approach was adopted to study the whole body mRNA changes upon administration of V...
January 21, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28104815/alterations-in-the-balance-of-tubulin-glycylation-and-glutamylation-in-photoreceptors-leads-to-retinal-degeneration
#15
Montserrat Bosch Grau, Christel Masson, Sudarshan Gadadhar, Cecilia Rocha, Olivia Tort, Patricia Marques Sousa, Sophie Vacher, Ivan Bieche, Carsten Janke
Tubulin is subject to a wide variety of posttranslational modifications, which as part of the tubulin code are involved in the regulation of microtubule functions. Glycylation has so far predominantly been found in motile cilia and flagella, and absence of this modification leads to ciliary disassembly. Here we demonstrate that the connecting cilia of photoreceptors, which are non-motile sensory cilia, are also dependent on glycylation. In contrast to many other tissues, only one glycylase, TTLL3, is expressed in retina...
January 19, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28101913/nasopharyngeal-colonization-with-streptococcus-pneumoniae-triggers-dendritic-cell-dependent-antibody-responses-against-invasive-disease-in-mice
#16
Anne Dommaschk, Nadine Ding, Meritxell Tort Tarres, Lara F Bittersohl, Regina Maus, Jennifer Stolper, Danny Jonigk, Peter Braubach, Torsten Lippmann, Tobias Welte, Ulrich A Maus
Nasopharyngeal colonization with Streptococcus pneumoniae (Spn) is an important precondition for the development of pneumococcal pneumonia. At the same time, nasopharyngeal colonization with Spn has been shown to mount adaptive immune responses against Spn in mice and humans. Cellular responses of the nasopharyngeal compartment, including the nasal-associated lymphoid tissue, to pneumococcal colonization and their importance for developing adaptive immune responses are poorly defined. We show that nasopharyngeal colonization with S...
January 19, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28060841/genomes-of-fasciola-hepatica-from-the-americas-reveal-colonization-with-neorickettsia-endobacteria-related-to-the-agents-of-potomac-horse-and-human-sennetsu-fevers
#17
Samantha N McNulty, Jose F Tort, Gabriel Rinaldi, Kerstin Fischer, Bruce A Rosa, Pablo Smircich, Santiago Fontenla, Young-Jun Choi, Rahul Tyagi, Kymberlie Hallsworth-Pepin, Victoria H Mann, Lakshmi Kammili, Patricia S Latham, Nicolas Dell'Oca, Fernanda Dominguez, Carlos Carmona, Peter U Fischer, Paul J Brindley, Makedonka Mitreva
Food borne trematodes (FBTs) are an assemblage of platyhelminth parasites transmitted through the food chain, four of which are recognized as neglected tropical diseases (NTDs). Fascioliasis stands out among the other NTDs due to its broad and significant impact on both human and animal health, as Fasciola sp., are also considered major pathogens of domesticated ruminants. Here we present a reference genome sequence of the common liver fluke, Fasciola hepatica isolated from sheep, complementing previously reported isolate from cattle...
January 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28017813/association-between-state-medical-malpractice-environment-and-postoperative-outcomes-in-the-united-states
#18
Christina A Minami, Catherine R Sheils, Emily Pavey, Jeanette W Chung, Jonah J Stulberg, David D Odell, Anthony D Yang, David J Bentrem, Karl Y Bilimoria
BACKGROUND: The US medical malpractice system assumes that the threat of liability should deter negligence, but it is unclear whether malpractice environment affects health care quality. We sought to explore the association between state malpractice environment and postoperative complication rates. STUDY DESIGN: This observational study included Medicare fee-for-service beneficiaries undergoing one of the following operations in 2010: colorectal, lung, esophageal, or pancreatic resection, total knee arthroplasty, craniotomy, gastric bypass, abdominal aortic aneurysm repair, coronary artery bypass grafting, or cystectomy...
March 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28011159/the-impact-of-state-tort-reforms-on-imaging-utilization
#19
Suhui Li, Avi Dor, Darwyyn Deyo, Danny R Hughes
PURPOSE: Defensive medicine, broadly defined as medical practices that protect physicians from malpractice lawsuits without providing benefits to patients, can lead to wasteful use of health care resources and higher cost. Although physicians cite malpractice liability as an important factor driving their decisions to order imaging tests, little research has been done to examine the systematic impact of liability pressure on overall imaging. The authors examined the extent to which radiography use is influenced by malpractice liability pressure among office-based physicians...
February 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28009242/an-analysis-of-malpractice-litigation-related-to-the-management-of-brain-aneurysms
#20
Raghav Gupta, Christoph J Griessenauer, Justin M Moore, Nimer Adeeb, Apar S Patel, Christopher S Ogilvy, Ajith J Thomas
OBJECTIVE Given the highly complex and demanding clinical environment in which neurosurgeons operate, the probability of facing a medical malpractice claim is high. Recent emphasis on tort reform within the political sphere has brought this issue to the forefront of medical literature. Despite the widespread fear of litigation in the medical community, few studies have provided an analysis of malpractice litigation in the field. Here, the authors attempt to delineate the medicolegal factors that impel plaintiffs to file medical malpractice claims related to the management of brain aneurysms, and to better characterize the nature of these lawsuits...
December 23, 2016: Journal of Neurosurgery
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