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https://www.readbyqxmd.com/read/28634082/cytokine-modulation-by-stress-hormones-and-antagonist-specific-hormonal-inhibition-in-rainbow-trout-oncorhynchus-mykiss-and-gilthead-sea-bream-sparus-aurata-head-kidney-primary-cell-culture
#1
Ali Reza Khansari, David Parra, Felipe E Reyes-López, Lluís Tort
A tight interaction between endocrine and immune systems takes place mainly due to the key role of head kidney in both hormone and cytokine secretion, particularly under stress situations in which the physiological response promotes the synthesis and release of stress hormones which may lead into immunomodulation as side effect. Although such interaction has been previously investigated, this study evaluated for the first time the effect of stress-associated hormones together with their receptor antagonists on the expression of cytokine genes in head kidney primary cell culture (HKPCC) of the freshwater rainbow trout (Oncorhynchus mykiss) and the seawater gilthead sea bream (Sparus aurata)...
June 17, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28599612/mycobacterioses-in-dogs-and-cats-from-buenos-aires-argentina
#2
Soledad Barandiaran, Marcela Martínez Vivot, Elvira Falzoni, María Jimena Marfil, Gabriela Pérez Tort, Paula Rovatti, Mónica Fernández, Ricardo Iachini, Fernanda Satek, Adriana Duchene, Martín José Zumárraga
Mycobacterioses can produce nonspecific clinical signs in dogs and cats that make diagnosis difficult. Furthermore, the full characterization of mycobacterial agents is not always possible or practical. We characterized mycobacteria detected through cytology in 12 dogs and 7 cats with generalized clinical signs from the province of Buenos Aires in Argentina. In dogs, molecular testing confirmed the presence of Mycobacterium avium subsp. hominissuis (MAH) in 8 cases and M. fortuitum in 1 case. All dogs were Miniature Schnauzers, suggesting that this breed may be more susceptible to M...
June 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28536507/dopamine-modulates-delta-gamma-phase-amplitude-coupling-in-the-prefrontal-cortex-of-behaving-rats
#3
Victoria Andino-Pavlovsky, Annie C Souza, Robson Scheffer-Teixeira, Adriano B L Tort, Roberto Etchenique, Sidarta Ribeiro
Dopamine release and phase-amplitude cross-frequency coupling (CFC) have independently been implicated in prefrontal cortex (PFC) functioning. To causally investigate whether dopamine release affects phase-amplitude comodulation between different frequencies in local field potentials (LFP) recorded from the medial PFC (mPFC) of behaving rats, we used RuBiDopa, a light-sensitive caged compound that releases the neurotransmitter dopamine when irradiated with visible light. LFP power did not change in any frequency band after the application of light-uncaged dopamine, but significantly strengthened phase-amplitude comodulation between delta and gamma oscillations...
2017: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/28512074/an-idea-whose-time-has-come-compensation-for-vaccine-related-injuries-and-death-in-india
#4
Sarojini Nadimpally, Sneha Banerjee, Deepa Venkatachalam, Divya Bhagianadh
This paper emphasises the urgent need for a compensation policy for those affected by adverse events following immunisation in India. In the absence of such a mechanism in the country, people claim compensation by taking recourse to tort law and have to face the ensuing uncertainty and challenges with regard to the award of compensation. The paper argues that people should be provided compensation in the event of death and serious adverse events following compulsory immunisation, irrespective of whether there is a causal association between the adverse event and the vaccine, on the basis of no fault compensation...
April 2017: Indian Journal of Medical Ethics
https://www.readbyqxmd.com/read/28505969/early-detection-of-learning-difficulties-when-confronted-with-novel-information-in-preclinical-alzheimer-s-disease-stage-1
#5
Adrià Tort-Merino, Natalia Valech, Claudia Peñaloza, Petra Grönholm-Nyman, María León, Jaume Olives, Ainara Estanga, Mirian Ecay-Torres, Juan Fortea, Pablo Martínez-Lage, José L Molinuevo, Matti Laine, Antoni Rodríguez-Fornells, Lorena Rami
We employed a highly demanding experimental associative learning test (the AFE-T) to explore memory functioning in Preclinical Alzheimer's Disease stage 1 (PreAD-1) and stage 2 (PreAD-2). The task consisted in the learning of unknown object/name pairs and our comprehensive setup allowed the analysis of learning curves, immediate recall, long-term forgetting rates at one week, three months, and six months, and relearning curves. Forty-nine cognitively healthy subjects were included and classified according to the presence or absence of abnormal CSF biomarkers (Control, n = 31; PreAD-1, n = 14; PreAD-2, n = 4)...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28500748/epidemiology-and-genetic-diversity-of-classic-human-astrovirus-among-hospitalized-children-with-acute-gastroenteritis-in-uruguay
#6
Fernando Lopez, Andrés Lizasoain, Matías Victoria, Cecilia Papalardo, Sebastian Castro, Edit Arreseigor, Patricia López, Rodney Colina
Classic Human Astrovirus (Classic HAstV) are one of the most important causes of pediatric acute gastroenteritis (AGE), after rotaviruses and arguably caliciviruses. The aim of this study was to determine the molecular epidemiology of Classic HAstV from 175 clinical samples, being 153 stools and 22 vomits, collected from pediatric hospitalized patients with AGE in Salto city, Uruguay, from January 2011 to December 2012. Classic HAstV were detected and genotyped by using a qualitative Retro Transcription-Polimerase Chain Reaction (RT-PCR) directed to the Open Reading Frame-2 (ORF2) region C...
May 13, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28499434/development-of-a-novel-immunochromatographic-lateral-flow-assay-specific-for-mycobacterium-bovis-cells-and-its-application-in-combination-with-immunomagnetic-separation-to-test-badger-faeces
#7
Linda D Stewart, Nuria Tort, Paul Meakin, Jose M Argudo, Ruramayi Nzuma, Neil Reid, Richard J Delahay, Roland Ashford, W Ian Montgomery, Irene R Grant
BACKGROUND: The European badger is an important wildlife reservoir of Mycobacterium bovis implicated in the spread of bovine tuberculosis in the United Kingdom and Ireland. Infected badgers are known to shed M. bovis in their urine and faeces, which may contaminate the environment. To aid bovine tuberculosis control efforts novel diagnostic tests for detecting infected and shedding badgers are needed. We proposed development of a novel, rapid immunochromatographic lateral flow device (LFD) as a non-invasive test to detect M...
May 12, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28478681/sensitive-determination-of-cd-in-small-volume-samples-by-miniaturized-liquid-drop-anode-atmospheric-pressure-glow-discharge-optical-emission-spectrometry
#8
Piotr Jamroz, Krzysztof Greda, Anna Dzimitrowicz, Krzysztof Swiderski, Pawel Pohl
A novel liquid drop anode (LDA) direct current atmospheric pressure glow discharge (dc-APGD) system was applied for direct determination of Cd in liquid microsamples (50 μL) by optical emission spectrometry (OES). The microdischarge was generated in open-to-air atmosphere between a solid pin type tungsten cathode and a liquid drop placed on a graphite disk anode. The arrangement of the graphite disk placed on a PTFE chip platform as well as the solid pin type cathode was simple and robust. The limit of detection (LOD) of Cd for the developed LDA-APGD-OES method was 0...
June 6, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28477295/do-tort-reforms-impact-the-incidence-of-birth-by-cesarean-section-a-reassessment
#9
Javier Cano-Urbina, Daniel Montanera
Investigations into the existence and impact of defensive medicine in obstetrics have produced mixed and often conflicting implications. The most widely-cited and accepted results in this literature find that less severe malpractice environments cause an increase in the use of cesarean section. This has been interpreted as "offensive medicine"; taking advantage of lenient malpractice environments by providing unnecessary services in order to raise revenue. In this article we show that an assumption concerning births with an unknown method of delivery, which is not explicitly stated in the literature, is pivotal in obtaining these results...
March 2017: International Journal of Health Economics and Management
https://www.readbyqxmd.com/read/28447703/conserved-effects-and-altered-trafficking-of-cetuximab-antibodies-conjugated-to-gold-nanoparticles-with-precise-control-of-their-number-and-orientation
#10
Lorena García-Fernández, Javier Garcia-Pardo, Olivia Tort, Ian Prior, Mathias Brust, Eudald Casals, Julia Lorenzo, Victor F Puntes
Gold nanoparticles (17 nm) have been functionalized with the antiangiogenic monoclonal antibody drug Cetuximab at a well-defined orientation and coverage density of antibodies. Functionalization has been carried out through site-directed chemistry via the selective oxidation of the carbohydrate moiety of antibodies linked to a thiolated hydrazide. A431 tumor cells have been exposed to these conjugates for in vitro evaluation of their effects. In addition to epithelial growth factor receptor blocking, trafficking and signaling alterations were also observed...
May 11, 2017: Nanoscale
https://www.readbyqxmd.com/read/28443945/-sex-and-gender-equity-in-research-rationale-for-the-sager-guidelines-and-recommended-use
#11
Shirin Heidari, Thomas F Babor, Paola De Castro, Sera Tort, Mirjam Curno
BACKGROUND: Sex and gender differences are often overlooked in research design, study implementation and scientific reporting, as well as in general science communication. This oversight limits the generalizability of research findings and their applicability to clinical practice, in particular for women but also for men. This article describes the rationale for an international set of guidelines to encourage a more systematic approach to the reporting of sex and gender in research across disciplines...
April 20, 2017: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://www.readbyqxmd.com/read/28434458/relationship-between-state-malpractice-environment-and-quality-of-health-care-in-the-united-states
#12
Karl Y Bilimoria, Jeanette W Chung, Christina A Minami, Min-Woong Sohn, Emily S Pavey, Jane L Holl, Michelle M Mello
BACKGROUND: One major intent of the medical malpractice system in the United States is to deter negligent care and to create incentives for delivering high-quality health care. A study was conducted to assess whether state-level measures of malpractice risk were associated with hospital quality and patient safety. METHODS: In an observational study of short-term, acute-care general hospitals in the United States that publicly reported in the Centers for Medicaid & Medicare Services Hospital Compare in 2011, hierarchical regression models were used to estimate associations between state-specific malpractice environment measures (rates of paid claims, average Medicare Malpractice Geographic Practice Cost Index [MGPCI], absence of tort reform laws, and a composite measure) and measures of hospital quality (processes of care, imaging utilization, 30-day mortality and readmission, Agency for Healthcare Research and Quality Patient Safety Indicators, and patient experience from the Hospital Consumer Assessment of Healthcare Providers and Systems [HCAHPS])...
May 2017: Joint Commission Journal on Quality and Patient Safety
https://www.readbyqxmd.com/read/28416292/participation-of-emergency-radiologists-in%C3%A2-tort-reform
#13
Dipan Danda, Jonathan L Mezrich
No abstract text is available yet for this article.
April 14, 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28396398/selective-entrainment-of-gamma-subbands-by-different-slow-network-oscillations
#14
Weiwei Zhong, Mareva Ciatipis, Thérèse Wolfenstetter, Jakob Jessberger, Carola Müller, Simon Ponsel, Yevgenij Yanovsky, Jurij Brankačk, Adriano B L Tort, Andreas Draguhn
Theta oscillations (4-12 Hz) are thought to provide a common temporal reference for the exchange of information among distant brain networks. On the other hand, faster gamma-frequency oscillations (30-160 Hz) nested within theta cycles are believed to underlie local information processing. Whether oscillatory coupling between global and local oscillations, as showcased by theta-gamma coupling, is a general coding mechanism remains unknown. Here, we investigated two different patterns of oscillatory network activity, theta and respiration-induced network rhythms, in four brain regions of freely moving mice: olfactory bulb (OB), prelimbic cortex (PLC), parietal cortex (PAC), and dorsal hippocampus [cornu ammonis 1 (CA1)]...
April 25, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28379154/retaliatory-rico-and-the-puzzle-of-fraudulent-claiming
#15
Nora Freeman Engstrom
Over the past century, the allegation that the tort liability system incentivizes legal extortion and is chock-full of fraudulent claims has dominated public discussion and prompted lawmakers to ever-more-creatively curtail individuals' incentives and opportunities to seek redress. Unsatisfied with these conventional efforts, in recent years, at least a dozen corporate defendants have "discovered" a new fraud-fighting tool. They've started filing retaliatory RICO suits against plaintiffs and their lawyers and experts, alleging that the initiation of certain nonmeritorious litigation constitutes racketeering activity—while tort reform advocates have applauded these efforts and exhorted more "courageous" companies to follow suit...
2017: Michigan Law Review
https://www.readbyqxmd.com/read/28376057/measurement-as-a-performance-driver-the-case-for-a-national-measurement-system-to-improve-patient-safety
#16
Thomas R Krause, Kristen J Bell, Peter Pronovost, Jason M Etchegaray
Safety metrics in healthcare settings stand apart from those in all other industries. Despite improvements in the measurement and prevention of adverse health outcomes following the 1999 Institute of Medicine report, no fully operational national-level program for monitoring patient harm exists. Here, we review the annual rate of fatal adverse events in healthcare settings in the United States on the basis of previous research, assess the current state of measurements of patient harm, propose a national standard to both quantify harm and act as a performance driver for improved safety, and discuss additional considerations such as accountability and implications for tort reform under this standard...
April 4, 2017: Journal of Patient Safety
https://www.readbyqxmd.com/read/28347974/whiplash-syndrome-reloaded-digital-echoes-of-whiplash-syndrome-in-the-european-internet-search-engine-context
#17
Michael Noll-Hussong
BACKGROUND: In many Western countries, after a motor vehicle collision, those involved seek health care for the assessment of injuries and for insurance documentation purposes. In contrast, in many less wealthy countries, there may be limited access to care and no insurance or compensation system. OBJECTIVE: The purpose of this infodemiology study was to investigate the global pattern of evolving Internet usage in countries with and without insurance and the corresponding compensation systems for whiplash injury...
March 27, 2017: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/28314501/legal-and-regulatory-barriers-to-reverse-innovation
#18
Virginia Rowthorn, Alexander J Plum, John Zervos
BACKGROUND: Reverse innovation, or the importation of new, affordable, and efficacious models to high-income countries from the developing world, has emerged as a way to improve the health care system in the United States. Reverse innovation has been identified as a key emerging trend in global health systems in part because low-resourced settings are particularly good laboratories for low-cost/high-impact innovations that are developed out of necessity. A difficult question receiving scant attention is that of legal and regulatory barriers...
November 2016: Annals of Global Health
https://www.readbyqxmd.com/read/28276144/malpractice-reduction-and-standardization-of-care-2-sides-of-the-same-coin
#19
Steven L Clark
The tort system in the U.S. functions poorly in adjudicating blame and providing compensation for adverse medical outcomes, and the overhead costs of this system are exorbitant. (Studdert etal.NEngJMed2006;354: 2024-33) The question is whether the system can be improved within the constraints of fairness and justice to both patients and providers, and the financial realities of a broken U.S. health care system. This article is protected by copyright. All rights reserved.
March 9, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28256499/portal-venous-thrombosis-developing-after-torsion-of-a-wandering-spleen
#20
Ö Yilmaz, R Kiziltan, N Almali, A Aras
Torsion of a wandering spleen is a rare disease. The symptoms and signs of this condition are only present when the splenic pedicle torts. The etiological factors are the congenital absence of the ligaments that hold the spleen in its normal anatomic position, or the relaxation of these ligaments resulting from conditions like trauma and abdominal surgery. We aimed to present a rare case with torsion of wandering spleen that consequently developed thrombosis of portal vein and its branches, taking into consideration the relevant literature...
March 2017: Nigerian Journal of Clinical Practice
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