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(Anterior cruciate ligament) AND osteoarthritis

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https://www.readbyqxmd.com/read/28420082/can-early-rehabilitation-prevent-posttraumatic-osteoarthritis-in-the-patellofemoral-joint-after-anterior-cruciate-ligament-rupture-understanding-the-pathological-features
#1
Nai-Jen Chang, Ming-You Shie, Kuan-Wei Lee, Pei-Hsi Chou, Chih-Chan Lin, Chih-Jou Chu
Knee instability resulting from anterior cruciate ligament (ACL) rupture is a high-risk factor for posttraumatic osteoarthritis (PTOA) in the patellofemoral joint (PFJ). However, whether non-weight-bearing and weight-bearing treatments have chondroprotective effects remains unclear. Twenty-four adult New Zealand White male rabbits were employed in this study. All animals received ACL transection in the right knee and sham surgery in the left knee. The rabbits were randomly assigned to the following groups: (I) In the sedentary (SED) group, the rabbits (n = 6) were simply kept in their cage; (II) In the continuous passive motion (CPM) group, the rabbits (n = 6) performed CPM exercise for 7 days, starting from the first postoperative day; (III) In the active treadmill exercise (TRE) group, the rabbits (n = 6) performed TRE for 2 weeks; (IV) In the CPM + TRE group, the rabbits (n = 6) executed CPM exercise, followed by TRE...
April 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28419155/culture-expanded-allogenic-adipose-tissue-derived-stem-cells-attenuate-cartilage-degeneration-in-an-experimental-rat-osteoarthritis-model
#2
Li Mei, Bojiang Shen, Peixue Ling, Shaoying Liu, Jiajun Xue, Fuyan Liu, Huarong Shao, Jianying Chen, Aibin Ma, Xia Liu
Mesenchymal stem cell (MSC)-based cell therapy is a promising avenue for osteoarthritis (OA) treatment. In the present study, we evaluated the efficacy of intra-articular injections of culture-expanded allogenic adipose tissue-derived stem cells (ADSCs) for the treatment of anterior cruciate ligament transection (ACLT) induced rat OA model. The paracrine effects of major histocompatibility complex (MHC)-unmatched ADSCs on chondrocytes were investigated in vitro. Rats were divided into an OA group that underwent ACLT surgery and a sham-operated group that did not undergo ACLT surgery...
2017: PloS One
https://www.readbyqxmd.com/read/28410217/pterostilbene-inhibits-inflammation-and-ros-production-in-chondrocytes-by-activating-nrf2-pathway
#3
En-Xing Xue, Jian-Ping Lin, Yu Zhang, Sun-Ren Sheng, Hai-Xiao Liu, Yu-Long Zhou, Hui Xu
Pterostilbene has been reported as a potential drug to inhibit oxidative stress and inflammation. However, the effect of pterostilbene on chondrocytes and osteoarthritis remains to be elucidated. We sought to investigate whether pterostilbene could protect chondrocytes from inflammation and ROS production through factor erythroid 2-related factor 2 (Nrf2) activation. The pterostilbene toxicity on chondrocytes collected from cartilages of Sprague-Dawley rats was assessed by CCK-8 test. Immunofluorescence and Western blotting explored the nuclear translocation of Nrf2...
March 30, 2017: Oncotarget
https://www.readbyqxmd.com/read/28397529/controlling-abnormal-joint-movement-inhibits-response-of-osteophyte-formation
#4
Kenji Murata, Takanori Kokubun, Yuri Morishita, Katsuya Onitsuka, Shuhei Fujiwara, Aya Nakajima, Tsutomu Fujino, Kiyomi Takayanagi, Naohiko Kanemura
Objective Osteoarthritis (OA) is induced by accumulated mechanical stress to joints; however, little has been reported regarding the cause among detailed mechanical stress on cartilage degeneration. This study investigated the influence of the control of abnormal joint movement induced by anterior cruciate ligament (ACL) injury in the articular cartilage. Design The animals were divided into 3 experimental groups: CAJM group ( n = 22: controlling abnormal joint movement), ACL-T group ( n = 22: ACL transection or knee anterior instability increased), and INTACT group ( n = 12: no surgery)...
April 1, 2017: Cartilage
https://www.readbyqxmd.com/read/28388231/sex-differences-in-high-school-athletes-knowledge-of-sport-related-concussion-symptoms-and-reporting-behaviors
#5
Jessica Wallace, Tracey Covassin, Erica Beidler
CONTEXT:   Recent researchers have reported that athletes' knowledge of sport-related concussion (SRC) has increased but that athletes still lack knowledge of all the signs and symptoms of SRC. Understanding the signs and symptoms of SRC and the dangers of playing while symptomatic are critical to reporting behaviors in high school athletes. OBJECTIVE:   To examine sex differences in knowledge of SRC symptoms and reasons for not reporting a suspected SRC to an authoritative figure in high school athletes...
April 18, 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/28383764/risk-factors-for-radiographic-joint-space-narrowing-and-patient-reported-outcomes-of-post-traumatic-osteoarthritis-after-acl-reconstruction-data-from-the-moon-cohort
#6
Morgan H Jones, Kurt P Spindler
The Multicenter Orthopaedic Outcomes Network (MOON) is an NIH-funded prospective, longitudinal cohort of over 3500 patients who have undergone anterior cruciate ligament reconstruction (ACLR) by 14 sports medicine surgeons at 7 academic medical centers. Patient reported outcome questionnaires (PRO's) are completed at baseline and multiple timepoints after surgery, and a nested cohort of patients return for radiographs to assess the development of joint space changes. We review the risk factors for worse patient reported outcomes, the predictors of clinically significant symptoms of post-traumatic osteoarthritis (PTOA), and the factors associated with more radiographic joint space narrowing...
April 6, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28367081/changes-of-articular-cartilage-and-subchondral-bone-after-extracorporeal-shockwave-therapy-in-osteoarthritis-of-the-knee
#7
Ching-Jen Wang, Jai-Hong Cheng, Wen-Yi Chou, Shan-Ling Hsu, Jen-Hung Chen, Chien-Yiu Huang
We assessed the pathological changes of articular cartilage and subchondral bone on different locations of the knee after extracorporeal shockwave therapy (ESWT) in early osteoarthritis (OA). Rat knees under OA model by anterior cruciate ligament transaction (ACLT) and medial meniscectomy (MM) to induce OA changes. Among ESWT groups, ESWT were applied to medial (M) femur (F) and tibia (T) condyles was better than medial tibia condyle, medial femur condyle as well as medial and lateral (L) tibia condyles in gross osteoarthritic areas (p<0...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/28366841/digital-image-correlation-aided-mechanical-characterization-of-the-anteromedial-and-posterolateral-bundles-of-the-anterior-cruciate-ligament
#8
Kaitlyn Mallett, Ellen M Arruda
The anterior cruciate ligament (ACL) is one of the most commonly injured soft tissue structures in the articular knee joint, often requiring invasive surgery for patients to restore pre-injury knee kinematics. There is a pressing need to understand the role of the ACL in knee function, in order to select proper replacements. Digital image correlation (DIC), a non-contact full field displacement measurement technique, is an established tool for evaluating non-biological materials. The application of DIC to soft tissues has been in the nascent stages, largely due to patterning challenges of such materials...
March 30, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28364321/satisfactory-outcomes-following-combined-unicompartmental-knee-replacement-and-anterior-cruciate-ligament-reconstruction
#9
REVIEW
Andrea Volpin, S G Kini, D E Meuffels
PURPOSE: There exist limited options for treatment of patients with combined medial compartment arthritis and anterior cruciate ligament (ACL) deficiency. Ideal treatment is one that offers lasting relief of symptoms not compromising any future surgery. Unicompartmental knee replacement has shown consistently good results in the relatively young and active population, but there is a high reported incidence of failure up to 20%, if performed in ACL-deficient knees. One of the recognized treatment modality is combined ACL reconstruction and unicompartmental arthroplasty...
March 31, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28361013/anterior-cruciate-ligament-reconstruction-and-knee-osteoarthritis
#10
EDITORIAL
Nikolaos K Paschos
Anterior cruciate ligament (ACL) injury is a traumatic event that can lead to significant functional impairment and inability to participate in high-level sports-related activities. ACL reconstruction is considered the treatment of choice for symptomatic ACL-deficient patients and can assist in full functional recovery. Furthermore, ACL reconstruction restores ligamentous stability to normal, and, therefore, can potentially fully reinstate kinematics of the knee joint. As a consequence, the natural history of ACL injury could be potentially reversed via ACL reconstruction...
March 18, 2017: World Journal of Orthopedics
https://www.readbyqxmd.com/read/28358372/tnf-%C3%AE-induced-lrg1-promotes-angiogenesis-and-mesenchymal-stem-cell-migration-in-the-subchondral-bone-during-osteoarthritis
#11
Yiyun Wang, Jiajia Xu, Xudong Zhang, Chuandong Wang, Yan Huang, Kerong Dai, Xiaoling Zhang
The incomplete understanding of aberrant neovascularization, which contributes to osteoarthritis suggests that additional modulators have yet to be identified. Our objective was to identify the role of Leucine-rich-alpha-2-glycoprotein1 (LRG1), a new regulator of pathogenic angiogenesis, in osteoarthritis progression and to develop effective treatment strategies. In this study, immunohistochemistry showed that LRG1 was increased in the subchondral bone and articular cartilage in anterior cruciate ligament transection (ACLT) mice...
March 30, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28355681/a-biomechanical-study-of-two-distinct-methods-of-anterior-cruciate-ligament-rupture-and-a-novel-surgical-reconstruction-technique-in-a-small-animal-model-of-posttraumatic-osteoarthritis
#12
Austin J Ramme, Matin S Lendhey, Eric J Strauss, Oran D Kennedy
Small animal models are critical for studies of sports-related knee injury and disease such as posttraumatic osteoarthritis (PTOA) following anterior cruciate ligament (ACL) rupture. In such models, ACL damage can be achieved by surgical transection or, using a more recent innovation, by noninvasive biomechanical means. Whether these approaches differentially alter normal mechanics is unknown. Furthermore, while surgical reconstruction of ruptured ACL can greatly improve joint stability, its effect on PTOA development is also unclear...
March 29, 2017: Journal of Knee Surgery
https://www.readbyqxmd.com/read/28345597/post-traumatic-osteoarthritis-in-mice-following-mechanical-injury-to-the-synovial-joint
#13
Muhammad Farooq Rai, Xin Duan, James D Quirk, Nilsson Holguin, Eric J Schmidt, Nobuaki Chinzei, Matthew J Silva, Linda J Sandell
We investigated the spectrum of lesions characteristic of post-traumatic osteoarthritis (PTOA) across the knee joint in response to mechanical injury. We hypothesized that alteration in knee joint stability in mice reproduces molecular and structural features of PTOA that would suggest potential therapeutic targets in humans. The right knees of eight-week old male mice from two recombinant inbred lines (LGXSM-6 and LGXSM-33) were subjected to axial tibial compression. Three separate loading magnitudes were applied: 6N, 9N, and 12N...
March 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28345412/effect-of-glucosamine-sulfate-on-osteoarthritis-in-the-cruciate-deficient-canine-model-of-osteoarthritis
#14
Wolfram Wenz, Christian Hornung, Christopher Cramer, Malte Schroeder, Michael Hoffmann
Objective Osteoarthritis (OA) is a major cause of musculoskeletal pain and disability worldwide. The investigation of disease-modifying treatment options for OA has become an important aspect of orthopedic care. To assess the effect of intra-articular and oral glucosamine sulfate (GS) versus placebo on osteoarthritis in a canine model. Materials In this randomized, placebo-controlled, double-blinded study, OA was induced by anterior cruciate ligament transection (ACLT) according to the Pond-Nuki model in 32 canines...
April 2017: Cartilage
https://www.readbyqxmd.com/read/28345404/are-bone-bruise-characteristics-and-articular-cartilage-pathology-associated-with-inferior-outcomes-2-and-6-years-after-anterior-cruciate-ligament-reconstruction
#15
Christian Lattermann, Cale A Jacobs, Emily K Reinke, Erica A Scaramuzza, Laura J Huston, Warren R Dunn, Kurt P Spindler
Objective To determine (1) if bone bruise characteristics seen on magnetic resonance imaging are associated with patient-reported outcomes prior to and following anterior cruciate ligament reconstruction and (2) if the combined presence of bone bruises with articular cartilage pathology results in inferior 2- or 6-year outcomes. Design Bone bruise volume and severity were measured on 81 patients' preoperative magnetic resonance imaging in the medial and lateral femoral condyle (MFC, LFC) and medial and lateral tibial plateau (MTP, LTP) using the Costa-Paz classification and a modified version of Roemer and Bohndorf's technique...
April 2017: Cartilage
https://www.readbyqxmd.com/read/28337590/acl-reconstructed-and-acl-deficient-individuals-show-differentiated-trunk-hip-and-knee-kinematics-during-vertical-hops-more-than-20%C3%A2-years-post-injury
#16
Jonas L Markström, Eva Tengman, Charlotte K Häger
PURPOSE: Little is known regarding movement strategies in the long term following injury of the anterior cruciate ligament (ACL), and even less about comparisons of reconstructed and deficient knees in relation to healthy controls. The present purpose was to compare trunk, hip, and knee kinematics during a one-leg vertical hop (VH) ~20 years post-ACL injury between persons treated with surgery and physiotherapy (ACLR), solely physiotherapy (ACLPT), and controls (CTRL). Between-leg kinematic differences within groups were also investigated...
March 23, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28325340/low-molecular-weight-xanthan-gum-for-treating-osteoarthritis
#17
Guanying Han, Qixin Chen, Fei Liu, Zan Cui, Huarong Shao, Fuyan Liu, Aibin Ma, Joshua Liao, Bin Guo, Yuewei Guo, Fengshan Wang, Peixue Ling, Xifan Mei
Osteoarthritis (OA) is one of the most common chronic diseases and characterized by degradation of articular cartilage. We have previously reported xanthan gum (XG) injection preparation with high molecular weights (Mw) in ranging from 3×10(6)Da to 5×10(6)Da (HM-XG) could enhance the viscosity of synovial fluid, protect joint cartilage in rabbit, and the therapeutical effect has no significance difference with an existing clinical medication (sodium hyaluronate, SH) at the same injection frequency (once weekly for 5 weeks)...
May 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28321429/intermediate-to-long-term-results-of-combined-anterior-cruciate-ligament-reconstruction-and-autologous-chondrocyte-implantation
#18
Andrew N Pike, Tim Bryant, Takahiro Ogura, Tom Minas
BACKGROUND: Cartilage injury associated with anterior cruciate ligament (ACL) ruptures is common; however, relatively few reports exist on concurrent cartilage repair with ACL reconstruction. Autologous chondrocyte implantation (ACI) has been utilized successfully for treatment of moderate to large chondral defects. HYPOTHESIS: ACL insufficiency with relatively large chondral defects may be effectively managed with concurrent ACL reconstruction and ACI. STUDY DESIGN: Case series; Level of evidence, 4...
February 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28314886/no-differences-in-subjective-knee-function-between-surgical-techniques-of-anterior-cruciate-ligament-reconstruction-at-2-year-follow-up-a-cohort-study-from-the-swedish-national-knee-ligament-register
#19
Eric Hamrin Senorski, David Sundemo, Christopher D Murawski, Eduard Alentorn-Geli, Volker Musahl, Freddie Fu, Neel Desai, Anders Stålman, Kristian Samuelsson
PURPOSE: The purpose of this study was to investigate how different techniques of single-bundle anterior cruciate ligament (ACL) reconstruction affect subjective knee function via the Knee injury and Osteoarthritis Outcome Score (KOOS) evaluation 2 years after surgery. It was hypothesized that the surgical techniques of single-bundle ACL reconstruction would result in equivalent results with respect to subjective knee function 2 years after surgery. METHODS: This cohort study was based on data from the Swedish National Knee Ligament Register during the 10-year period of 1 January 2005 through 31 December 2014...
March 17, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28289822/combined-anterior-cruciate-ligament-reconstruction-and-lateral-extra-articular-tenodesis-does-not-result-in-an-increased-rate-of-osteoarthritis-a-systematic-review-and-best-evidence-synthesis
#20
REVIEW
Brian M Devitt, Nicolas Bouguennec, Kristoffer W Barfod, Tabitha Porter, Kate E Webster, Julian A Feller
PURPOSE: The role of lateral extra-articular tenodesis (LEAT) as an augment to primary anterior cruciate ligament reconstruction (ACLR) remains controversial. However, concerns exist regarding the risk of development of osteoarthritis due to over constraint of the knee. To systematically review the literature to analyse the long-term incidence of osteoarthritis in patients who had an LEAT performed in isolation or in combination with intra-articular ACLR for the treatment of ACL deficiency...
March 13, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
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