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(Anterior cruciate ligament) AND osteoarthritis

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https://www.readbyqxmd.com/read/29143973/effects-of-microrna-24-targeting-c-myc-on-apoptosis-proliferation-and-cytokine-expressions-in-chondrocytes-of-rats-with-osteoarthritis-via-mapk-signaling-pathway
#1
Yuan-Hao Wu, Wei Liu, Lei Zhang, Xiao-Ya Liu, Yi Wang, Bin Xue, Bin Liu, Ran Duan, Bo Zhang, Yang Ji
OBJECTIVE: To investigate whether microRNA-24 (miR-24) targeting C-myc affects chondrocytes of rats with osteoarthritis (OA) via the MAPK signaling pathway. METHODS: Thirty rats were assigned as a sham group and an OA group (established as OA rat models by cutting the anterior cruciate ligaments and removing 1/3 medial meniscus). TUNEL staining and immunohistochemistry were conducted for cell apoptosis index (AI) and positive expression rate of C-myc protein. Enzyme-linked immuno sorbent assay (ELISA) was carried out for serum level of IL-1β and TNF-α...
November 16, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29137611/diagnostic-validity-and-triage-concordance-of-a-physiotherapist-compared-to-physicians-diagnoses-for-common-knee-disorders
#2
S Décary, M Fallaha, B Pelletier, P Frémont, J Martel-Pelletier, J-P Pelletier, D E Feldman, M-P Sylvestre, P-A Vendittoli, F Desmeules
BACKGROUND: Emergence of more autonomous roles for physiotherapists warrants more evidence regarding their diagnostic capabilities. Therefore, we aimed to evaluate diagnostic and surgical triage concordance between a physiotherapist and expert physicians and to assess the diagnostic validity of the physiotherapist's musculoskeletal examination (ME) without imaging. METHODS: This is a prospective diagnostic study where 179 consecutive participants consulting for any knee complaint were independently diagnosed and triaged by two evaluators: a physiotherapist and one expert physician (orthopaedic surgeons or sport medicine physicians)...
November 14, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29134251/meniscal-repair-results-in-inferior-short-term-outcomes-compared-with-meniscal-resection-a-cohort-study-of-6398-patients-with-primary-anterior-cruciate-ligament-reconstruction
#3
Eleonor Svantesson, Riccardo Cristiani, Eric Hamrin Senorski, Magnus Forssblad, Kristian Samuelsson, Anders Stålman
PURPOSE: To compare patient reported outcome measures (PROMs) during the first postoperative year between isolated anterior cruciate ligament (ACL) reconstruction and ACL reconstruction with concomitant meniscal intervention. METHODS: Patients who underwent primary ACL reconstruction at Capio Artro Clinic, Stockholm, Sweden, between 1st Jan 2001 and 31st Dec 2014 without concomitant injuries others than meniscal and/or cartilage lesions were included. Five groups of meniscal treatment simultaneously to ACL reconstruction were established; medial meniscal (MM) resection, MM repair, lateral meniscal (LM) resection, LM repair, and MM + LM resection...
November 13, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29129614/mid-term-clinical-functional-and-radiographic-outcomes-of-105-gender-specific-patellofemoral-arthroplasties-with-or-without-the-association-of-medial-unicompartmental-knee-arthroplasty
#4
Sergio Romagnoli, Matteo Marullo
BACKGROUND: The purpose of this study is to evaluate clinical and radiographic outcomes after gender-specific patellofemoral arthroplasty (PFA) either isolated or combined with unicompartmental knee arthroplasty (UKA). METHODS: A total of 105 PFAs in 85 patients were reviewed: 64 knees had isolated patellofemoral osteoarthritis and received an isolated PFA, and 41 knees with bicompartmental osteoarthritis were treated with medial UKA and PFA. Preoperative and postoperative clinical and functional assessment included knee range of motion, Knee Society Score, University of California Los Angeles Activity Score, Tegner Activity Level Scale, and visual analogue scale pain...
October 24, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29125920/frontal-plane-knee-mechanics-and-early-cartilage-degeneration-in-people-with-anterior-cruciate-ligament-reconstruction-a-longitudinal-study
#5
Deepak Kumar, Favian Su, Daniel Wu, Valentina Pedoia, Lauren Heitkamp, C Benjamin Ma, Richard B Souza, Xiaojuan Li
BACKGROUND: Abnormal frontal plane gait mechanics are known risk factors for knee osteoarthritis, but their role in early cartilage degeneration after anterior cruciate ligament reconstruction (ACLR) is not well understood. Hypothesis/Purpose: The objective was to evaluate the association of frontal plane gait mechanics with medial knee cartilage magnetic resonance (MR) relaxation times over 1 year in patients with ACLR and controls. It was hypothesized that (1) there will be an increase in frontal plane medial knee loading and medial knee MR relaxation times over time in the patients with ACLR, and (2) increases in frontal plane medial knee loading will be associated with an increase in medial knee MR relaxation times...
November 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29125013/diagnostic-value-of-combined-serum-marker-changes-and-quantitative-mri-evaluation-of-cartilage-volume-of-tibial-plateau-in-a-surgically-induced-osteoarthritis-dog-model
#6
Jiangdong Ren, Jinsai Ma, Xiaogang Zhang, Abdusami Aimaiti, Maimaitiming Saiyiti, Yuming Chen, Li Cao
Objective To evaluate the combined diagnostic value of two serum osteoarthritis (OA) markers and quantitative magnetic resonance imaging (MRI) evaluation of the cartilage volume of the tibial plateau in a canine model of experimental OA. Methods A total of 18 male Beagle dogs were used in this longitudinal study. OA was surgically induced via anterior cruciate ligament transection (ACLT) of the right knee in 10 dogs. The remaining eight dogs formed the sham operation control group and underwent the same procedure without ACLT...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/29114629/knee-osteoarthritis-after-reconstruction-of-isolated-anterior-cruciate-ligament-injuries-a-systematic-literature-review
#7
REVIEW
Compagnoni Riccardo, Catani Fabio, Randelli Pietro
Purpose  The aim of this review was to analyze the current literature on osteoarthritic evolution of knees without any combined meniscal or ligament lesions undergoing anterior cruciate ligament (ACL) reconstruction. Methods  A PubMed/MEDLINE research was performed using the following keywords: "Anterior Cruciate Ligament Reconstruction" [Mesh] AND "Osteoarthritis, Knee" [Mesh]. Only English language literature and articles published after 2005 were included. Studies including concomitant meniscal tears, posterior cruciate or collateral ligament injuries, previous surgery in the affected knees, infections, osteochondral defects, loose bodies, synovial plica syndrome, and posteromedial or posterolateral corner injuries were not considered in this review...
March 2017: Joints
https://www.readbyqxmd.com/read/29114625/revision-anterior-cruciate-ligament-reconstruction-with-contralateral-hamstring-tendon-grafts-6-years-follow-up
#8
Claudio Legnani, Stefania Zini, Enrico Borgo, Alberto Ventura
Purpose  The purpose of this study was to retrospectively evaluate the clinical outcome of revision anterior cruciate ligament (ACL) reconstruction with contralateral hamstring tendon autografts, specifically with regard to patient satisfaction, return to preinjury activity level, and postoperative functional outcomes. Methods  Between 2004 and 2011, 23 patients underwent revision ACL reconstruction with contralateral autogenous hamstring tendon grafts and were retrospectively reviewed at an average follow-up of 6...
March 2017: Joints
https://www.readbyqxmd.com/read/29093428/danshen-attenuates-cartilage-injuries-in-osteoarthritis-in-vivo-and-in-vitro-by-activating-jak2-stat3-and-akt-pathways
#9
Xilin Xu, Hang Lv, Xiaodong Li, Hui Su, Xiaofeng Zhang, Jun Yang
Articular cartilage degradation is a main feature of osteoarthritis (OA). The effects of Danshen, a traditional Chinese herb, in mitigating cartilage damage have been reported before. This study was conducted to investigate the effects of Danshen on cartilage injuries in OA. Rabbit OA models were established by surgical destabilization of the medial meniscus and the anterior and posterior cruciate ligaments in the left knee joint. Injection of Danshen into the articular cavity attenuated OA cartilage destruction in vivo...
October 31, 2017: Experimental Animals
https://www.readbyqxmd.com/read/29070587/ghrelin-protects-against-osteoarthritis-through-interplay-with-akt-and-nf-%C3%AE%C2%BAb-signaling-pathways
#10
Ruize Qu, Xiaomin Chen, Wenhan Wang, Cheng Qiu, Miaomiao Ban, Linlin Guo, Krasimir Vasilev, Jianying Chen, Weiwei Li, Yunpeng Zhao
Osteoarthritis (OA) is a common chronic degenerative disease characterized by degeneration in the joints and subsequent destruction of cartilage and bone, yet much remains to be elucidated regarding its molecular mechanism. Ghrelin is a recently discovered neuropeptide with anti-inflammatory actions, but it is unknown whether ghrelin is involved in OA. Human primary chondrocyte and cartilage samples were collected from patients with OA, and the expression pattern of ghrelin was assessed. Human chondrocyte and cartilage samples were stimulated with IL-1β and TNF-α, and exogenous ghrelin-alleviated disorganization of catabolism and anabolism were mediated by IL-1β and TNF-α...
October 25, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29058776/osteophytes-and-fracture-calluses-share-developmental-milestones-and-are-diminished-by-unloading
#11
Allison W Hsia, Armaun J Emami, Franklin D Tarke, Hailey C Cunningham, Priscilla M Tjandra, Alice Wong, Blaine A Christiansen, Nicole M Collette
Osteophytes are a typical radiographic finding during osteoarthritis (OA), but the mechanisms leading to their formation are not well known. Comparatively, fracture calluses have been studied extensively, therefore drawing comparisons between osteophytes and fracture calluses may lead to a deeper understanding of osteophyte formation. In this study we compared the time courses of osteophyte and fracture callus formation, and investigated mechanisms contributing to development of these structure. Additionally, we investigated the effect of mechanical unloading on the formation of both fracture calluses and osteophytes...
October 23, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29051896/outcomes-and-complication-rates-after-primary-anterior-cruciate-ligament-reconstruction-are-similar-in-younger-and-older-patients
#12
Mark E Cinque, Jorge Chahla, Gilbert Moatshe, Nicholas N DePhillipo, Nicholas I Kennedy, Jonathan A Godin, Robert F LaPrade
BACKGROUND: Until recently, anterior cruciate ligament (ACL) tears in older patients were treated conservatively; however, these patients often experienced significant pain and instability. PURPOSE/HYPOTHESIS: The purpose of this study was to compare the patient-reported outcomes, patient satisfaction, and failure rates of primary ACL reconstruction between a younger (age 20-30 years) and older (age 50-75 years) patient cohort. It was hypothesized that patients in the older cohort could achieve comparable clinical outcomes and retear rates following ACL reconstruction with a bone-tendon-bone autograft or allograft compared with the younger patients...
October 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29039525/the-association-between-parathyroid-hormone-1%C3%A2-34-and-the-wnt-%C3%AE-%C3%A2-catenin-signaling-pathway-in-a-rat-model-of-osteoarthritis
#13
Long Ma, Jiang Wu, Qun Hua Jin
The aim of the current study was to determine the effect of parathyroid hormone (PTH) 1‑34 on cartilage degeneration, and the association between PTH 1‑34 and factors associated with the Wnt/β‑catenin pathway following anterior cruciate ligament and medial meniscectomy‑induced osteoarthritis (OA) in rats. A total of 64 Sprague‑Dawley rats were randomly divided into the following four groups: Sham‑operated rats with normal saline (NS)‑treatment (n=16); anterior cruciate ligament transection with partial medial meniscectomy (ACLT + MMx) rats with NS‑treatment (n=16); sham‑operated rats treated with PTH 1‑34 (n=16); and ACLT + MMx rats treated with PTH 1‑34 (n=16)...
December 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29039445/isoliquiritigenin-suppresses-il-1%C3%AE-induced-apoptosis-and-inflammation-in-chondrocyte-like-atdc5-cells-by-inhibiting-nf-%C3%AE%C2%BAb-and-exerts-chondroprotective-effects-on-a-mouse-model-of-anterior-cruciate-ligament-transection
#14
Baochao Ji, Wentao Guo, Hairong Ma, Boyong Xu, Wenbo Mu, Zhendong Zhang, Abdusami Amat, Li Cao
Isoliquiritigenin (ISL), a natural flavonoid extracted from licorice, has been demonstrated to exert attenuation of the nuclear factor-κB (NF-κB) signaling pathway and anti-inflammatory activity in a wide variety of cells. In the present study, the authors first evaluated the effects of ISL on cartilage degeneration in interleukin-1β (IL-1β)-stimulated chondrocyte-like ATDC5 cells and in a mouse model of osteoarthritis (OA). The data of a cell counting kit-8 and flow cytometry assay indicated that ISL suppressed the inhibitory effect of IL-1β on cell viability...
October 9, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29032484/young-athletes-return-too-early-to-knee-strenuous-sport-without-acceptable-knee-function-after-anterior-cruciate-ligament-reconstruction
#15
Susanne Beischer, Eric Hamrin Senorski, Christoffer Thomeé, Kristian Samuelsson, Roland Thomeé
PURPOSE: The purpose of this study was to evaluate the return to knee-strenuous sport rate, muscle function and subjective knee function among adolescent patients (15-20 years of age) and adult patients (21-30 years of age) 8 and 12 months, respectively, after anterior cruciate ligament (ACL) reconstruction. It was hypothesised that no differences in outcome would be found between age groups at 8 or 12 months after ACL reconstruction. METHODS: Cross-sectional data from five tests of muscle function, from the Knee injury and Osteoarthritis Outcome Score (KOOS) and the Tegner Activity Scale (Tegner), performed at 8 and 12 months after a primary ACL reconstruction, were extracted from a rehabilitation outcome register...
October 14, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29031199/artesunate-attenuates-aclt-induced-osteoarthritis-by-suppressing-osteoclastogenesis-and-aberrant-angiogenesis
#16
Chengjin Zhao, Qingbai Liu, Kunzheng Wang
Artesunate (ART) is a semi-synthetic derivative of artemisinin and used preferentially in treatment of malaria in China. ART has strong anti-inflammatory, anti-tumor, and anti-angiogenic properties. Although the pharmacological effect of ART in osteoarthritis (OA) is unknown, evidence suggests that ART might regulate osteoclastogenesis through NF-κB signaling. In this study we explored the therapeutic effect of ART in an anterior cruciate ligament transection (ACLT)-induced OA model. We found that ART effectively relieved ACLT-induced osteoarthritis, as demonstrated by the improvement expression of pathological genes...
October 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29030067/adipose-tissue-derived-stem-cells-in-combination-with-xanthan-gum-attenuate-osteoarthritis-progression-in-an-experimental-rat-model
#17
Li Mei, Bojiang Shen, Jiajun Xue, Shaoying Liu, Aibin Ma, Fuyan Liu, Huarong Shao, Jianying Chen, Qixin Chen, Fei Liu, Yong Ying, Peixue Ling
The current study explored the efficacy of an intra-articular (IA) injection of allogeneic adipose tissue-derived stem cells (ADSCs) combined with xanthan gum (XG) in a rat osteoarthritis (OA) model. We confirmed that XG significantly inproved proliferation of ADSCs in a dose dependent manner in vitro. The rat OA model was induced by an anterior cruciate ligament transection (ACLT), and at 4 weeks after surgery, rats were divided into four groups: the XG-ADSCs group, the ADSCs group, the XG group and the phosphate-buffered saline (PBS) group...
December 9, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29020716/improving-joint-pain-and-function-in-osteoarthritis
#18
REVIEW
Claire Owens, Philip G Conaghan
Osteoarthritis has become a major chronic pain condition. It affects more than 10% of adults and accounts for almost 10% of health service resources. The impact of osteoarthritis is amplified by underuse of effective muscle strengthening exercises and a focus on often less effective and poorly tolerated analgesic therapies. Although traditionally considered to be primarily a disease of cartilage, there is now ample evidence that typical clinical osteoarthritis involves multiple tissue pathologies. Increased BMI is associated with a higher incidence of knee osteoarthritis...
December 2016: Practitioner
https://www.readbyqxmd.com/read/28991041/quadriceps-function-and-knee-joint-ultrasonography-following-acl-reconstruction
#19
Derek N Pamukoff, Melissa M Montgomery, Tyler J Moffit, Michael N Vakula
PURPOSE: Individuals with anterior cruciate ligament reconstruction (ACLR) are at greater risk for knee osteoarthritis (OA), partially due to chronic quadriceps dysfunction. Articular cartilage is commonly assessed using magnetic resonance imaging and radiography, but these methods are expensive and lack portability. Ultrasound imaging may provide a cost-effective and portable alternative for imaging the femoral cartilage. The purpose of this study was to compare ultrasonography of the femoral cartilage between the injured and uninjured limbs of individuals with unilateral ACLR, and to examine the association between quadriceps function and ultrasonographic measures of femoral cartilage...
October 3, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28990574/an-evidence-based-evaluation-on-the-use-of-platelet-rich-plasma-in-orthopedics-a-review-of-the-literature
#20
Nasir Hussain, Herman Johal, Mohit Bhandari
Within orthopedics, the use of platelet-rich plasma (PRP) has been rapidly increasing in popularity, however, its true effectiveness has yet to be fully established. Several studies find that injecting PRP to the site of injury does not provide any significant benefit with respect to clinical outcomes; however, many others report the contrary. Due to the conflicting evidence and multiple meta-analyses conducted on the topic, a literature review of high-quality evidence on the use of PRP for common orthopaedic conditions was performed...
2017: SICOT-J
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