keyword
MENU ▼
Read by QxMD icon Read
search

(Anterior cruciate ligament) AND osteoarthritis

keyword
https://www.readbyqxmd.com/read/29329888/associations-between-cartilage-proteoglycan-density-and-patient-outcomes-12months-following-anterior-cruciate-ligament-reconstruction
#1
Brian Pietrosimone, Daniel Nissman, Darin A Padua, J Troy Blackburn, Matthew S Harkey, Robert A Creighton, Ganesh M Kamath, Kaitlin Healy, Randy Schmitz, Jeffrey B Driban, Steve W Marshall, Joanne M Jordan, Jeffrey T Spang
BACKGROUND: Lower proteoglycan density (PGD) of the articular cartilage may be an early marker of osteoarthritis following anterior cruciate ligament (ACL) reconstruction (ACL-R). The purpose this study was to determine associations between the Knee Injury and Osteoarthritis Outcomes Score (KOOS) and PGD of the articular cartilage in the femur and tibia 12-months following ACL-R. METHODS: We evaluated KOOS pain, symptoms, function in activities of daily living (ADL), function in sport and recreation (Sport), and quality of life (QOL), as well as PGD using T1rho magnetic resonance imaging in 18 individuals 12...
January 9, 2018: Knee
https://www.readbyqxmd.com/read/29318172/clinical-factors-that-predict-a-second-acl-injury-after-acl-reconstruction-and-return-to-sport-preliminary-development-of-a-clinical-decision-algorithm
#2
Mark V Paterno, Bin Huang, Staci Thomas, Timothy E Hewett, Laura C Schmitt
Background: Biomechanical predictors of a second anterior cruciate ligament (ACL) injury after ACL reconstruction (ACLR) and return to sport (RTS) have been identified; however, these measures may not be feasible in a standard clinical environment. Purpose/Hypothesis: The purpose of this study was to evaluate whether standard clinical measures predicted the risk of second ACL injuries. The hypothesis tested was that a combination of strength, function, and patient-reported measures at the time of RTS would predict the risk of second ACL injuries with high sensitivity and specificity...
December 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29318168/the-utility-of-objective-strength-and-functional-performance-to-predict-subjective-outcomes-after-anterior-cruciate-ligament-reconstruction
#3
Heather Menzer, Lindsay V Slater, David Diduch, Mark Miller, Grant Norte, John Goetschius, Joseph M Hart
Background: Many clinicians release patients to return to activity after anterior cruciate ligament reconstruction (ACLR) based on time from surgery despite deficits in muscle strength and function. It is unclear whether symmetry or unilateral performance is the best predictor of subjective outcomes after ACLR. Purpose: To determine physical performance predictors of patient-reported outcomes after reconstruction. Study Design: Cross-sectional study; Level of evidence, 3...
December 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29317848/traumatic-osteoarthritis-induced-persistent-mechanical-hyperalgesia-in-a-rat-model-of-anterior-cruciate-ligament-transection-plus-a-medial-meniscectomy
#4
Hsiao-Chien Tsai, Ta-Liang Chen, Yu-Pin Chen, Ruei-Ming Chen
Background: Osteoarthritis (OA) is a degenerative joint disease characterized by progressive cartilage degeneration, subchondral bone changes, osteophyte formation, and synovitis. A major symptom is pain that is triggered by peripheral and central changes within the pain pathways. Some surgery-induced joint instability rat models of OA were described to mimic traumatic OA. Several behavioral tests were developed to access OA-induced pain. However, follow-up in most studies usually only occurred for about 4 weeks...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29315787/metabolomic-serum-profiling-after-acl-injury-in-rats-a-pilot-study-implicating-inflammation-and-immune-dysregulation-in-post-traumatic-osteoarthritis
#5
Tristan Maerz, Eric Sherman, Michael Newton, Ali Yilmaz, Praveen Kumar, Stewart F Graham, Kevin C Baker
ACL rupture is a major risk factor for post-traumatic osteoarthritis (PTOA) development. Little information exists on acute systemic metabolic indicators of disease development. 36 female Lewis rats were randomized to Control or noninvasive anterior cruciate ligament rupture (ACLR) and to three post-injury time points: 72 hours, 4 weeks, 10 weeks (n = 6). Serum was collected and analyzed by 1 H nuclear magnetic resonance (NMR) spectroscopy and combined direct injection and liquid chromatography (LC)-mass spectrometry (MS)/MS (DI-MS)...
January 8, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29309029/acl-status-in-arthroplasty-patients-why-not-to-preserve
#6
Ahmed Abdelbadie, Ahmed Ali Toreih, Mohamed Ahmed Radwan
INTRODUCTION: Only 70-85% of patients that had total knee arthroplasty (TKA) are satisfied with their knees. The need for a near to normal knee kinematics is crucial and maybe the solution to their needs. Addressing the cruciate ligaments during surgery along with the extent of arthrosis may give a solution to this problem. MATERIAL AND METHODS: One hundred consecutive patients in whom a total knee arthroplasty was indicated and performed were prospectively documented...
2018: SICOT-J
https://www.readbyqxmd.com/read/29284176/bone-patellar-tendon-bone-autograft-versus-hamstring-tendon-autograft-for-anatomical-anterior-cruciate-ligament-reconstruction-with-three-dimensional-validation-of-femoral-and-tibial-tunnel-positions
#7
Shuji Taketomi, Hiroshi Inui, Ryota Yamagami, Nobuyuki Shirakawa, Kohei Kawaguchi, Takumi Nakagawa, Sakae Tanaka
The purpose of this retrospective study was to first compare the clinical outcome of anatomical double-bundle (DB) anterior cruciate ligament reconstruction (ACLR) with hamstring tendon (HT) autografts and anatomical rectangular tunnel ACLR with bone-patellar tendon-bone (BPTB) autografts. Secondly, we aimed to demonstrate the quantitative locations of the femoral and tibial tunnel apertures using postoperative three-dimensional computed tomography (3D CT).Twenty-five patients underwent anatomical rectangular tunnel ACLR using BPTB grafts (Group B) and 23 patients underwent anatomical DB ACLR using HT grafts (Group H)...
December 28, 2017: Journal of Knee Surgery
https://www.readbyqxmd.com/read/29244223/fixed-bearing-medial-unicompartmental-knee-arthroplasty-restores-neither-the-medial-pivoting-behavior-nor-the-ligament-forces-of-the-intact-knee-in-passive-flexion
#8
Mohammad Kia, Lucian C Warth, Joseph D Lipman, Timothy M Wright, Geoffrey H Westrich, Michael B Cross, David J Mayman, Andrew D Pearle, Carl W Imhauser
Medial unicompartmental knee arthroplasty (UKA) is an accepted treatment for isolated medial osteoarthritis. However, using an improper thickness for the tibial component may contribute to early failure of the prosthesis or disease progression in the unreplaced lateral compartment. Little is known of the effect of insert thickness on both knee kinematics and ligament forces. Therefore, a computational model of the tibiofemoral joint was used to determine how non-conforming, fixed bearing medial UKA affects tibiofemoral kinematics and tension in the medial collateral ligament (MCL) and the anterior cruciate ligament (ACL) during passive knee flexion...
December 15, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29233184/effects-of-angelicae-pubescentis-and-loranthi-decotion-on-repairing-knee-joint-cartilages-in-rats
#9
Shun Lyu, Bin Ji, Wenwu Gao, Xianqi Chen, Xiaotao Xie, Junjie Zhou
BACKGROUND: Knee osteoarthritis (KOA) is a common orthopedics disease and its pathological changes at early stage are the damage and loss of articular cartilage. Traditional Chinese medicine (TCM) prescription contains multiple components and has the unique advantages of the diversity of targets.We compared the traditional Chinese medical formulae (Angelicae Pubescentis and Loranthi decotion, APLD, or Duhuo Jisheng) with a western medicine (glucosamine sulfate, GS) to treat the rat arthritis models, and tracked the outcomes...
December 12, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29228600/non-invasive-in-vivo-molecular-imaging-of-intra-articularly-transplanted-immortalized-bone-marrow-stem-cells-for-osteoarthritis-treatment
#10
Bou-Yue Peng, Chi-Sheng Chiou, Navneet Kumar Dubey, Sung-Hsun Yu, Yue-Hua Deng, Feng-Chou Tsai, Han-Sun Chiang, Ying-Hua Shieh, Wei-Hong Chen, Win-Ping Deng
Pathophysiology of osteoarthritis (OA) is characterized by progressive loss of articular cartilage in the knee-joints. To impart regenerative ability in lowly metabolizing chondrocytes, the bone marrow stem cells (BMSCs) has recently been recognized as a superior alternative treatment for OA. However, study of primary BMSCs-mediated chondrogenesis is difficult due to progressive cellular aging and replicative senescence. To obtain a therapeutic cell population for OA, BMSCs were immortalized by human papilloma virus (HPV)-16 E6/E7 along with mCherry luciferase (mCL), a gene marker for non-invasive imaging, and designated as iBMSCs-mCL...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29221902/a-comparison-of-patellofemoral-cartilage-morphology-and-deformation-in-anterior-cruciate-ligament-deficient-versus-uninjured-knees
#11
Kwadwo A Owusu-Akyaw, Lauren N Heckelman, Hattie C Cutcliffe, E Grant Sutter, Zoë A Englander, Charles E Spritzer, William E Garrett, Louis E DeFrate
Anterior cruciate ligament (ACL) deficient patients have an increased rate of patellofemoral joint (PFJ) osteoarthritis (OA) as compared to the general population. Although the cause of post-injury OA is multi-factorial, alterations in joint biomechanics may predispose patients to cartilage degeneration. This study aimed to compare in vivo PFJ morphology and mechanics between ACL deficient and intact knees in subjects with unilateral ACL ruptures. Eight male subjects underwent baseline MRI scans of both knees...
November 27, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29208323/evaluation-of-posterior-cruciate-ligament-and-intercondylar-notch-in-subjects-with-anterior-cruciate-ligament-tear-a-comparative-flexed-knee-3d-magnetic-resonance-imaging-study
#12
Atul K Taneja, Frederico C Miranda, Marco K Demange, Marcelo P Prado, Durval C B Santos, Laercio A Rosemberg, Ronaldo H Baroni
PURPOSE: To determine if posterior cruciate ligament (PCL) and intercondylar notch (IN) morphometries and volumetrics act as risk factors for anterior cruciate ligament (ACL) tears. METHODS: A prospective case-controlled magnetic resonance imaging (MRI) study was conducted with subjects presenting noncontact knee injuries. Exclusion criteria were previous surgery, PCL tear, osteoarthritis, tumors, or infectious and inflammatory conditions. All participants underwent a flexed-knee 3-dimensional (3D) magnetic resonance imaging (MRI) to uniformly straighten PCL...
December 2, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29205898/effects-of-oral-glucosamine-hydrochloride-and-mucopolysaccharide-protein-in-a-rabbit-model-of-osteoarthritis
#13
Da-Hee Jeong, H M Arif Ullah, Moon-Jung Goo, Soong-Gu Ghim, Il-Hwa Hong, Ah-Young Kim, Sun-Min Jeon, Myung-Sook Choi, Ahmed K Elfadl, Myung-Jin Chung, Eun-Joo Lee, Yong D Kim, Jun-Hyung Kim, Shin-Yoon Kim, Kyu-Shik Jeong
AIM: The aim was to study whether oral glucosamine hydrochloride (GlcN.HCl) or mucopolysaccharide protein (MucoP) has a structure-modifying effect on an anterior cruciate ligament transection (ACLT) rabbit model of osteoarthritis (OA). METHODS: OA was surgically induced in the right knees of rabbits by transection of the ACLT. The left knees served as a sham-operated control. The animals were divided into four groups (n = 6 each): negative control (phosphate buffered saline, orally), positive control (oral celecoxib 10 mg/kg body weight/day), GlcN...
December 5, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29205258/sustained-intra-cartilage-delivery-of-low-dose-dexamethasone-using-a-cationic-carrier-for-treatment-of-post-traumatic-osteoarthritis
#14
A G Bajpayee, R E De la Vega, M Scheu, N H Varady, I A Yannatos, L A Brown, Y Krishnan, T J Fitzsimons, P Bhattacharya, E H Frank, A J Grodzinsky, R M Porter
Disease-modifying osteoarthritis drugs (DMOADs) should reach their intra-tissue target sites at optimal doses for clinical efficacy. The dense, negatively charged matrix of cartilage poses a major hindrance to the transport of potential therapeutics. In this work, electrostatic interactions were utilised to overcome this challenge and enable higher uptake, full-thickness penetration and enhanced retention of dexamethasone (Dex) inside rabbit cartilage. This was accomplished by using the positively charged glycoprotein avidin as nanocarrier, conjugated to Dex by releasable linkers...
December 5, 2017: European Cells & Materials
https://www.readbyqxmd.com/read/29201194/protective-effect-of-zoledronic-acid-on-articular-cartilage-and-subchondral-bone-of-rabbits-with-experimental-knee-osteoarthritis
#15
Guorong She, Ziqi Zhou, Zhengang Zha, Fei Wang, Xiaoting Pan
Subchondral bone reabsorption and remodeling are responsible for the initiation and progression of osteoarthritis (OA). Zoledronic acid (ZOL), a third-generation bisphosphonate (BIS), is an inhibitor of bone reabsorption. However, the intervention effect of ZOL on OA has not been fully characterized and remains to be directly demonstrated in animal experiments. The present study examined the microscopic and macroscopic changes in the anterior cruciate ligament transection (ACLT) model of OA in rabbits and evaluated the effects of ZOL on cartilage degeneration and subchondral bone loss...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29191469/role-of-anterolateral-reconstruction-in-patients-undergoing-anterior-cruciate-ligament-reconstruction
#16
REVIEW
C Lutz
There is renewed interest in anterolateral reconstruction (ALR) for patients undergoing anterior cruciate ligament (ACL) reconstruction. This is the result of isolated ACL reconstruction and double-bundle reconstruction providing inadequate control over the pivot shift, and recent anatomical and biomechanical studies on the anterolateral ligament (ALL) and its role in the knee's rotational stability.From a technical point of view, ALR can be performed either as a continuity of the intra-articular ACL reconstruction or an independent procedure...
November 27, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29189335/outcomes-of-anterior-cruciate-ligament-reconstruction-in-obese-and-overweight-patients-a-systematic-review
#17
Kevin J DiSilvestro, Julio J Jauregui, Elizabeth Glazier, Denis Cherkalin, Craig H Bennett, Jonathan D Packer, Ralph Frank Henn
OBJECTIVE: To evaluate the mechanism of injury, outcomes, and complications of anterior cruciate ligament (ACL) reconstruction in overweight and obese patients. DATA SOURCES: MEDLINE, EMBASE, and OVID electronic libraries were systematically searched from inception to December, 2017 for any eligible articles using a combination of the phrases "anterior cruciate ligament," "ACL," "overweight," "obese," and "BMI." RESULTS: Studies that evaluated patients with primary ACL reconstruction, classified patients as overweight or obese, and reported a minimum of 1-year follow-up data were included...
November 20, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29185004/poor-knee-function-after-acl-reconstruction-is-associated-with-attenuated-landing-force-and-knee-flexion-moment-during-running
#18
Luke G Perraton, Michelle Hall, Ross A Clark, Kay M Crossley, Yong-Hao Pua, Tim S Whitehead, Hayden G Morris, Adam G Culvenor, Adam L Bryant
PURPOSE: Poor knee function after anterior cruciate ligament reconstruction (ACLR) may increase the risk of future knee symptoms and knee osteoarthritis via abnormal knee joint loading patterns, particularly during high-impact activity. This study aimed to assess the relationship between poor self-reported or clinically measured knee function and knee moments/vertical ground reaction force (vGRF) in individuals following ACLR. METHODS: 61 participants (mean 16.5 ± 3 months following ACLR, 23 women) completed a patient-reported knee function questionnaire and three hop tests (% of uninvolved limb)...
November 28, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29183885/can-we-predict-the-clinical-outcome-of-arthroscopic-partial-meniscectomy-a-systematic-review
#19
REVIEW
Susanne M Eijgenraam, Max Reijman, Sita M A Bierma-Zeinstra, Daan T van Yperen, Duncan E Meuffels
NHS-PROSPERO REGISTRATION NUMBER: 42016048592 OBJECTIVE: In order to make a more evidence-based selection of patients who would benefit the most from arthroscopic partial meniscectomy (APM), knowledge of prognostic factors is essential. We conducted a systematic review of predictors for the clinical outcome following APM. DESIGN: Systematic review DATA SOURCES: Medline, Embase, Cochrane Central Register, Web of Science, SPORTDiscus, PubMed Publisher, Google Scholar INCLUSION CRITERIA: Report an association between factor(s) and clinical outcome; validated questionnaire; follow-up >1 year...
November 28, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29164130/comparison-of-an-innovative-rehabilitation-combining-reduced-conventional-rehabilitation-with-balneotherapy-and-a-conventional-rehabilitation-after-anterior-cruciate-ligament-reconstruction-in-athletes
#20
Laetitia Peultier-Celli, Didier Mainard, Frank Wein, Nicolas Paris, Patrick Boisseau, Alexandre Ferry, René Gueguen, Isabelle Chary-Valckenaere, Jean Paysant, Philippe Perrin
Background: Instability of the knee, related to anterior cruciate ligament injury, is treated by surgical reconstruction. During recovery, a loss of proprioceptive input can have a significant impact. Few studies have evaluated the benefits of rehabilitation of the knee in aquatic environment on functional outcomes. Objective: This study aimed to compare an innovative rehabilitation protocol combining reduced conventional rehabilitation with aquatic rehabilitation, with a conventional rehabilitation, according to the National French Health Authority, in terms of kinetics, development of proprioceptive skills, and functional improvement of the knee...
2017: Frontiers in Surgery
keyword
keyword
14678
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"