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(Anterior cruciate ligament) AND osteoarthritis

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https://www.readbyqxmd.com/read/29781550/walking-gait-asymmetries-six-months-following-anterior-cruciate-ligament-reconstruction-predict-twelve-month-patient-reported-outcomes
#1
Brian Pietrosimone, J Troy Blackburn, Darin A Padua, Steven J Pfeiffer, Hope C Davis, Brittney A Luc-Harkey, Matthew S Harkey, Laura E Stanley, Barnett S Frank, R Alexander Creighton, Ganesh M Kamath, Jeffery T Spang
The study sought to determine the association between gait biomechanics (vertical ground reaction force [vGRF], vGRF loading rate [vGRF-LR]) collected six months following anterior cruciate ligament reconstruction (ACLR) with patient-reported outcomes at twelve months following ACLR. Walking gait mechanics and all subsections of the Knee Injury and Osteoarthritis Outcomes Score (KOOS) were collected at six and twelve months following ACLR, respectively, in 25 individuals with a unilateral ACLR. Peak vGRF and peak instantaneous vGRF-LR were extracted from the first 50% of the stance phase...
May 21, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29780834/factors-affecting-the-achievement-of-a-patient-acceptable-symptom-state-1-year-after-anterior-cruciate-ligament-reconstruction-a-cohort-study-of-343-patients-from-2-registries
#2
Eric Hamrin Senorski, Eleonor Svantesson, Susanne Beischer, Alberto Grassi, Ferid Krupic, Roland Thomeé, Kristian Samuelsson
Background: There is insufficient knowledge regarding the influence of concomitant injuries on the recovery of short-term subjective knee function after anterior cruciate ligament (ACL) reconstruction. Purpose: To determine whether patient characteristics, concomitant injuries, and graft choice during ACL reconstruction can predict which patients achieve acceptable knee function 1 year after reconstruction. Study Design: Case-control study; Level of evidence, 3...
April 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29778418/correlation-between-translational-and-rotational-kinematic-abnormalities-and-osteoarthritis-like-damage-in-two-in-vivo-sheep-injury-models
#3
Mehdi Shekarforoush, Jillian E Beveridge, David A Hart, Cyril B Frank, Nigel G Shrive
The relations between kinematic abnormalities and post traumatic osteoarthritis have not yet been clearly elucidated. This study was conducted to determine the finite helical axes parameters and the tibiofemoral translation vector in the knee joints of two surgically induced injury sheep models: anterior cruciate ligament and medial collateral ligament transection (ACL/MCL Tx) (n = 5) and lateral meniscectomy (n = 5). We hypothesized that morphological damage in the experimental joints would be correlated to alterations in these kinematic variables...
May 16, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29775379/decision-to-return-to-sport-participation-after-anterior-cruciate-ligament-reconstruction-part-ii-self-reported-and-functional-performance-outcomes
#4
Jennifer L Werner, Julie P Burland, Carl G Mattacola, Jenny Toonstra, Robert A English, Jennifer S Howard
CONTEXT:   Anterior cruciate ligament (ACL) reconstruction (ACLR) is the most commonly used method for helping athletes regain function and return to preinjury activity levels after ACL injury. Outcomes after ACLR have suggested that athletes return to a level of function that would support a return to sport participation; however, in a recent meta-analysis, pooled return rates were only 55%. It is unclear whether this discrepancy is a result of functional impairments. OBJECTIVE:   To compare patient-reported outcomes (PROs), dynamic balance, dynamic functional performance, strength, and muscular endurance in athletes who have returned to sport (RTS) and athletes who have not returned to sport (NRTS) after ACLR...
May 18, 2018: Journal of Athletic Training
https://www.readbyqxmd.com/read/29772990/the-effects-of-meniscal-geometry-on-susceptibility-for-meniscal-and-acl-injury-in-non-arthritic-knees-a-retrospective-case-control-study
#5
Alexander Tejani, Qais Naziri, Preston W Grieco, Robert Pivec, Damon Greene, Bhaveen V Kapadia, Dipal Chatterjee, William P Urban
Prior studies have not found significant differences in meniscal parameters between patients with meniscal and ligamentous injury and those without. The purpose of this study was to determine whether such relationships exist. Clinical records and magnetic resonance images of three subject groups were reviewed. Group 1 solely had meniscal tears (medial/lateral), Group 2 had meniscal tears with concurrent ACL tears, and Group 3 had healthy knees. The mean age of subjects included was 35.9 years (range 8.2-72...
2018: Journal of Long-term Effects of Medical Implants
https://www.readbyqxmd.com/read/29768019/does-anterior-cruciate-ligament-reconstruction-affect-the-outcome-of-osteochondral-allograft-transplantation-a-matched-cohort-study-with-a-mean-follow-up-of-6-years
#6
Luís E P Tírico, Julie C McCauley, Pamela A Pulido, William D Bugbee
BACKGROUND: Few studies have evaluated the influence of anterior cruciate ligament (ACL) reconstruction on the outcome of cartilage repair. Hypothesis/Purpose: The purpose was to investigate the association between ACL reconstruction and functional outcomes after osteochondral allograft (OCA) transplantation. The hypothesis was that patients treated with OCA transplantation who had a history of ACL reconstruction would have inferior clinical outcomes and lower osteochondral graft survivorship when compared with a matched group of patients undergoing OCA transplantation without a history of ACL reconstruction...
May 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29761560/mtor-mediated-inactivation-of-4e-bp1-an-inhibitor-of-translation-precedes-cartilage-degeneration-in-rat-osteoarthritic-knees
#7
Olga Katsara, Victoria Kolupaeva
Proper control of protein synthesis is vital for tissue homeostasis and its deregulation is characteristic of many disorders including osteoarthritis (OA). The objectives of this work were to analyze and correlate changes in activity of the translation apparatus associated with cartilage degeneration in an animal model of OA. Osteoarthritis was induced surgically in rats by anterior cruciate ligament transection (ACLT). Using a modified Mankin scoring system and analysis of protein expression we demonstrated, that mechanistic target of rapamycin complex 1 (mTORC1)-mediated 4E-BP1 phosphorylation was detected significantly earlier than other mTORC1-mediated modifications, such as p70S6K and ULK1 phosphorylation...
May 14, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29741911/long-term-comparison-of-semitendinosus-and-gracilis-tendon-versus-patellar-tendon-autografts-for-anterior-cruciate-ligament-reconstruction-a-17-year-follow-up-of-a-randomized-controlled-trial
#8
Matjaz Sajovic, Domen Stropnik, Katja Skaza
BACKGROUND: Short-term and mid-term differences between hamstring and patellar tendon autografts for anterior cruciate ligament (ACL) reconstruction are well documented. Systematic reviews highlight the lack of long-term results between the two grafts. HYPOTHESIS: Seventeen years after ACL reconstruction, no difference will be found in functional outcome, quality of life, and graft failure between patients with patellar tendon (PT) or semitendinosus and gracilis tendon (STG) autografts; however, a significant difference will be seen in the prevalence of osteoarthritis...
May 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29741400/anterolateral-ligament-reconstruction-protects-the-repaired-medial-meniscus-a-comparative-study-of-383-anterior-cruciate-ligament-reconstructions-from-the-santi-study-group-with-a-minimum-follow-up-of-2-years
#9
Bertrand Sonnery-Cottet, Adnan Saithna, William G Blakeney, Herve Ouanezar, Amrut Borade, Matt Daggett, Mathieu Thaunat, Jean-Marie Fayard, Jean Romain Delaloye
BACKGROUND: The prevalence of osteoarthritis after successful meniscal repair is significantly less than that after failed meniscal repair. PURPOSE: To determine whether the addition of anterolateral ligament reconstruction (ALLR) confers a protective effect on medial meniscal repair performed at the time of anterior cruciate ligament reconstruction (ACLR). STUDY DESIGN: Cohort study; Level of evidence, 3. METHODS: Retrospective analysis of prospectively collected data was performed to include all patients who had undergone primary ACLR with concomitant posterior horn medial meniscal repair through a posteromedial portal between January 2013 and August 2015...
May 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29733680/change-in-koos-and-womac-scores-in-a-young-athletic-population-with-and-without-anterior-cruciate-ligament-injury
#10
Ivan J Antosh, Steven J Svoboda, Karen Y Peck, E'Stephan J Garcia, Kenneth L Cameron
BACKGROUND: Several studies have examined changes in patient-reported outcome measures (PROMs) after anterior cruciate ligament (ACL) injury, but no studies to date have prospectively evaluated changes from preinjury baseline through injury and follow-up among ACL-injured patients compared to the baseline and follow-up changes of uninjured patients. PURPOSE: To examine changes in PROMs over time from preinjury baseline to at least 2 years after ACL reconstruction and to compare these changes with those of an uninjured control group having similar physical activity requirements...
May 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29731319/the-influence-of-tibial-slope-on-the-graft-in-combined-high-tibial-osteotomy-and-anterior-cruciate-ligament-reconstruction
#11
Philipp Schuster, Markus Geßlein, Michael Schlumberger, Philipp Mayer, Jörg Richter
BACKGROUND: Young patients with severe medial osteoarthritis, varus malalignment and insufficiency of the anterior cruciate ligament (ACL) are difficult to treat. The tibial slope has gained attention with regard to osteotomies and ligamentous instability. The purpose was to evaluate the outcome of combined high tibial osteotomy (HTO), ACL reconstruction and chondral resurfacing (CR, abrasion plus microfracture), and to analyse graft failure rates with regard to the tibial slope. METHODS: Fifty cases (48...
May 3, 2018: Knee
https://www.readbyqxmd.com/read/29730857/the-role-of-osteotomy-for-the-treatment-of-pcl-injuries
#12
REVIEW
João V Novaretti, Andrew J Sheean, Jayson Lian, Joseph De Groot, Volker Musahl
PURPOSE OF REVIEW: The purposes of this review are to (1) describe the anatomic and biomechanical rationale for high tibial osteotomy (HTO) in the setting of posterior cruciate ligament (PCL) deficiency, (2) review the indications for concomitant HTO and PCL reconstruction, (3) provide guidance for the clinical assessment of the patient with suspected PCL deficiency, and (4) summarize the key surgical steps necessary to attain the appropriate sagittal and coronal plane corrections. RECENT FINDINGS: The preponderance of available biomechanical data pertaining to the PCL-deficient knee suggests that an increased proximal tibial slope limits posterior tibial translation under axial compressive loads...
May 5, 2018: Current Reviews in Musculoskeletal Medicine
https://www.readbyqxmd.com/read/29709011/muscle-wasting-in-osteoarthritis-model-induced-by-anterior-cruciate-ligament-transection
#13
Jordana Miranda de Souza Silva, Paulo Vinicius Gil Alabarse, Vivian de Oliveira Nunes Teixeira, Eduarda Correa Freitas, Francine Hehn de Oliveira, Rafael Mendonça da Silva Chakr, Ricardo Machado Xavier
This study aimed to investigate the molecular pathways involved in muscle wasting in an animal model of osteoarthritis (OA) induced by anterior cruciate ligament transection (ACLT) in rats. Reduction of protein syntheses, increased proteolysis and impaired muscle regeneration are important pathways related to muscle wasting, and myogenin, MyoD, myostatin and MuRF-1 are some of their markers. Female Wistar rats were allocated into two groups: OA (submitted to the ACLT) and SHAM (submitted to surgery without ACLT)...
2018: PloS One
https://www.readbyqxmd.com/read/29705925/knees-acl-has-superior-responsiveness-compared-to-the-most-commonly-used-patient-reported-outcome-measures-for-anterior-cruciate-ligament-injury
#14
Jonathan David Comins, Volkert Dirk Siersma, Martin Lind, Bent Wulff Jakobsen, Michael Rindom Krogsgaard
PURPOSE: For clinical trials, it is essential that measures are sensitive to change. The aim of this study was to conduct a head-to-head comparison of responsiveness of four PROMs used to measure outcome after anterior cruciate ligament (ACL) reconstruction. The PROMs compared were the knee injury osteoarthritis outcome score (KOOS), the international knee documentation committee subjective form (IKDC), the Lysholm score, and the knee numeric-entity evaluation score (KNEES-ACL). We hypothesized that KNEES-ACL would be more responsive than the other PROMs, as KNEES-ACL was created based on patient interviews and validated using Rasch analysis...
April 28, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29705172/the-effect-of-arch-drop-on-tibial-rotation-and-tibiofemoral-contact-stress-in-postpartum-women
#15
Kaitlin Rabe, Neil A Segal, Saphia Waheed, Donald D Anderson
BACKGROUND: Women are at higher risk for knee osteoarthritis and numerous other lower limb musculoskeletal disorders. Arch drop during pregnancy and the resultant excessive pronation of the feet may alter loading patterns and contribute to the higher prevalence of knee osteoarthritis in women. OBJECTIVE: To determine the effect of arch drop on tibial rotation and tibiofemoral contact stress. DESIGN: Interventional study with internal control SETTING: Biomechanics laboratory PARTICIPANTS: Eleven postpartum women (age 33...
April 26, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29694389/site-specific-glycosaminoglycan-content-is-better-maintained-in-the-pericellular-matrix-than-the-extracellular-matrix-in-early-post-traumatic-osteoarthritis
#16
Simo P Ojanen, Mikko A J Finnilä, Aino E Reunamo, Ari P Ronkainen, Santtu Mikkonen, Walter Herzog, Simo Saarakkala, Rami K Korhonen
INTRODUCTION: One of the characteristics of early osteoarthritis (OA) is the loss of fixed charged density (FCD) of glycosaminoglycans in the superficial zone of articular cartilage. However, possible local changes in the FCD content of the pericellular matrix (PCM) are not fully understood. Hence, our aim was to investigate the effect of unilateral anterior cruciate ligament transection (ACLT) in rabbit knees on estimated FCD in the PCM compared to that in the ECM, and relate these results with cell morphology...
2018: PloS One
https://www.readbyqxmd.com/read/29687303/effects-of-psidium-guajava-linn-leaf-extract-in-japanese-subjects-with-knee-pain-a-randomized-double-blind-placebo-controlled-parallel-pilot-study
#17
Shingo Kakuo, Takashi Fushimi, Keiko Kawasaki, Junji Nakamura, Noriyasu Ota
The extract of Psidium guajava Linn. (guava) leaf was recently revealed to suppress the advance of osteoarthritis (OA) in rat anterior cruciate ligament-transection models. To investigate the efficacy of guava leaf extract in improving knee pain, which is a common symptom of OA, we conducted a double-blind parallel pilot clinical study in Japanese subjects with knee pain. The subjects, who had no medical history of knee treatment, were randomly assigned to two groups with similar total Japanese Knee Osteoarthritis Measure (JKOM) scores...
April 23, 2018: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29678623/differences-in-subchondral-bone-plate-and-cartilage-thickness-between-women-with-anterior-cruciate-ligament-reconstructions-and-uninjured-controls
#18
Jennifer L Bhatla, Andres Kroker, Sarah L Manske, Carolyn A Emery, Steven K Boyd
OBJECTIVE: Anterior cruciate ligament (ACL) tears increase early onset osteoarthritis (OA) risk leading to cartilage and bone degradation. While the contribution of bone in OA development is unclear, evidence suggests that bone changes accompany cartilage degradation. This study aims to assess if regions with differences in subchondral bone plate thickness have differences in cartilage thickness when comparing ACL reconstructed (ACLR) knees of women ≥5 years post-injury to contralateral and controls with uninjured knees...
April 17, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29678170/self-reported-functional-recovery-after-reconstruction-versus-repair-in-acute-anterior-cruciate-ligament-rupture-rotor-a-randomized-controlled-clinical-trial
#19
Barbara C Boer, Roy A G Hoogeslag, Reinoud W Brouwer, Anna Demmer, Rianne M H A Huis In 't Veld
BACKGROUND: Anterior cruciate ligament (ACL) reconstruction is today's surgical gold standard for ACL rupture. Although it provides satisfactory results, not all patients return to their previous activity level and moreover, early posttraumatic osteoarthritis is not prevented. As such, a renewed interest has emerged in ACL suture repair combined with dynamic augmentation. Compared to ACL reconstruction, the hypothesized advantages of ACL suture repair are earlier return to sports, reduction of early posttraumatic osteoarthritis and preservation of the patient's native ACL tissue and proprioceptive envelope of the knee...
April 20, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29675503/factors-affecting-subjective-and-objective-outcomes-and-return-to-play-in-anterior-cruciate-ligament-reconstruction-a-retrospective-cohort-study
#20
Federica Rosso, Davide E Bonasia, Umberto Cottino, Simone Cambursano, Federico Dettoni, Roberto Rossi
Purpose  To analyze the prognostic factors influencing subjective and objective outcomes and return to play (RTP) after anterior cruciate ligament reconstruction (ACL-R). Methods  Primary ACL-Rs using a transtibial technique performed between 2008 and 2012 were included. Data regarding patients, surgery, sports, and rehabilitation, including an on-field rehabilitation (OFR) and duration of the rehabilitation program, were collected. The International Knee Documentation Committee (IKDC) subjective and objective evaluation forms, and the Knee Injury and Osteoarthritis Outcome Score and Lysholm questionnaires were used for the assessment of subjective and objective outcomes...
March 2018: Joints
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