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(Anterior cruciate ligament) AND biomarker

Valentina Pedoia, Colin Russell, Allison Randolph, Xiaojuan Li, Sharmila Majumdar
BACKGROUND: Quantitative MR, including T1ρ mapping, has been extensively used to probe early biochemical changes in knee articular cartilage of subjects with osteoarthritis (OA) and others at risk for cartilage degeneration, such as those with anterior cruciate ligament (ACL) injury and reconstruction. However, limited studies have been performed aimed to assess the spatial location and patterns of T1ρ. In this study we used a novel voxel-based relaxometry (VBR) technique coupled with principal component analysis (PCA) to extract relevant features so as to describe regional patterns and to investigate their similarities and differences in T1ρ maps in subjects with OA and subjects six months after ACL reconstruction (ACLR)...
December 2016: Quantitative Imaging in Medicine and Surgery
Brett D Owens, Kenneth L Cameron, Steven L Bokshan, Kari B Clifton, Steven J Svoboda, Jennifer Moriatis Wolf
Differences in cartilage biomarkers have been noted in patients with anterior cruciate ligament tears, but little is known about any similar relationship with shoulder instability. This study evaluated the relationship between serum cartilage biomarkers and shoulder instability. The authors present a prospective cohort study of young athletes followed from 2006 to 2010. A nested case-control analysis was conducted within this cohort to evaluate the association between preinjury collagen type II cleavage (a marker for type II collagen cleavage) and procollagen II carboxy propeptide (a marker of cartilage synthesis) and the subsequent likelihood of shoulder instability during the 4-year follow-up period...
September 29, 2016: Orthopedics
(no author information available yet)
Svoboda SJ, Owens BD, Harvey TM, Tarwater PM, Brechue WF, Cameron KL. The association between serum biomarkers of collagen turnover and subsequent anterior cruciate ligament rupture. Am J Sports Med 2016;44(7):1687-1693. (Original DOI: 10.1177/0363546516640515)In the above article, the affiliation for Travis M. Harvey was incorrectly listed. The correct affiliation is United States Special Operations Command, MacDill Air Force Base, Florida, USA.
September 2016: American Journal of Sports Medicine
Jenna Le, Qi Peng, Karen Sperling
Osteoarthritis (OA) is a disease whose hallmark is the degeneration of articular cartilage. There is a worsening epidemic of OA in the United States today, with considerable economic costs. In order to develop more effective treatments for OA, noninvasive biomarkers that permit early diagnosis and treatment monitoring are necessary. T1rho and T2 mapping are two magnetic resonance imaging techniques that have shown great promise as noninvasive biomarkers of cartilage degeneration. Each of the two techniques is endowed with advantages and disadvantages: T1rho can discern earlier biochemical changes of OA than T2 mapping, while T2 mapping is more widely available and can be incorporated into existing imaging protocols in a more time-efficient manner than T1rho...
November 2016: Annals of the New York Academy of Sciences
Weilin Liu, Jian He, Ruhui Lin, Jie Liang, Qinglu Luo
The present study investigated the differential proteomics of synovial membranes between bilateral and unilateral anterior cruciate ligament transection (ACLT) in rabbits with knee osteoarthritis (KOA), in order to elucidate the pathological biomarkers of different degrees of KOA. A total of 6 New Zealand rabbits were randomly divided into groups A and B (three rabbits per group). The two groups were subjected to bilateral and unilateral ACLT, respectively. A total of 6 weeks following surgery, proteins were extracted from the knee joint synovial membranes of KOA rabbits and were separated by two‑dimensional polyacrylamide gel electrophoresis...
September 2016: Molecular Medicine Reports
Yonghui Dong, Hui Liu, Xuejun Zhang, Fei Xu, Liang Qin, Peng Cheng, Hui Huang, Fengjing Guo, Qing Yang, Anmin Chen
Previous studies showed that SDF-1α is a catabolic factor that can infiltrate cartilage, decrease proteoglycan content, and increase MMP-13 activity. Inhibiting the SDF-1α/CXCR4 signalling pathway can attenuate the pathogenesis of osteoarthritis (OA). Recent studies have also shown that SDF-1α enhances chondrocyte proliferation and maturation. These results appear to be contradictory. In the current study, we used a destabilisation OA animal model to investigate the effects of SDF-1α/CXCR4 signalling in the tibial subchondral bone and the OA pathological process...
June 16, 2016: International Journal of Molecular Sciences
Christian Lattermann, Cale A Jacobs, Mary Proffitt Bunnell, Kate Jochimsen, John Abt, Emily K Reinke, Lee Gammon, Janet L Huebner, Virginia B Kraus, Kurt P Spindler
Anterior cruciate ligament (ACL) injuries are common and lead to posttraumatic osteoarthritis (PTOA) in a high percentage of patients. Research has been ineffective in identifying successful treatment options for people suffering from symptomatic PTOA resulting in a shift of focus towards the young, ACL injured patients at risk of developing PTOA. Randomized clinical trials examining the very early phase after ACL injury are ideal to study this population; however, these trials face significant challenges regarding recruitment as well as reproducibility of patient-reported outcomes (PROs) and inflammatory and/or chondrodegenerative biomarkers associated with early PTOA...
June 9, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Steven J Svoboda, Brett D Owens, Travis M Harvey, Patrick M Tarwater, William F Brechue, Kenneth L Cameron
BACKGROUND: No study has attempted to associate the levels of preinjury serum biomarkers of collagen turnover with the subsequent risk of anterior cruciate ligament (ACL) injury. HYPOTHESIS: Preinjury serum biomarkers of collagen turnover would be associated with the subsequent risk of ACL injury. STUDY DESIGN: Case-control study; Level of evidence, 3. METHODS: We conducted a case-control study with 45 ACL-injured cases and 45 controls matched for sex, age, height, and weight...
July 2016: American Journal of Sports Medicine
Jarred Kaiser, Michael F Vignos, Fang Liu, Richard Kijowski, Darryl G Thelen
BACKGROUND: The pathogenesis of osteoarthritis following anterior cruciate ligament (ACL) reconstruction is currently unknown. The study purpose was to leverage recent advances in quantitative and dynamic MRI to test the hypothesis that abnormal joint mechanics within four years of reconstruction is accompanied by evidence of early compositional changes in cartilage. METHODS: Static MR imaging was performed bilaterally on eleven subjects with an ACL reconstruction (1-4years post-surgery) and on twelve healthy subjects to obtain tibial cartilage thickness maps...
May 2016: Clinical Biomechanics
María Carmen Terencio, María Luisa Ferrándiz, María Carmen Carceller, Ramón Ruhí, Pere Dalmau, Josep Vergés, Eulàlia Montell, Anna Torrent, María José Alcaraz
CONTEXT: The efficacy of the combination chondroitin sulfate-glucosamine (CS-GlcN) in the treatment of knee osteoarthritis (OA) has been suggested in recent clinical studies. In vitro reports have also suggested anti-inflammatory and anti-resorptive effects of this combination. OBJECTIVE: The aim of this study was to characterize the effects of CS-GlcN on joint degradation in vivo including the assessment of inflammation and bone metabolism in a model of OA. MATERIALS AND METHODS: We have used the OA model induced by anterior cruciate ligament transection (ACLT) in ovariectomised rats...
April 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Nicole M Cattano, Jeffrey B Driban, Mary F Barbe, Ryan Tierney, Mamta Amin, Michael R Sitler
The purpose of this study was to determine if an association existed between self-reported symptom and function scores and tissue turnover or inflammatory biomarker changes after a running bout among individuals with and without an acute knee-injury history. A pre-test/post-test prospective cohort study design (Level II) of 22 participants was conducted. Eleven physically active individuals with a history of anterior cruciate ligament surgery and/or meniscus surgery within 4 years of study participation were matched to 11 healthy control participants...
March 31, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Riann M Palmieri-Smith, Edward M Wojtys, Hollis G Potter
PURPOSE: To determine if magnetic resonance imaging markers of cartilage matrix and morphology and circulating serum biomarkers of inflammation and matrix degradation differ over time in patients with anterior cruciate ligament (ACL) injury and bone marrow edema lesions (BMELs) when compared with matched control subjects. METHODS: We performed a case-control study, in which 11 ACL-injured subjects scheduled to undergo reconstruction and 11 matched control subjects were scheduled for testing...
July 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
Terese L Chmielewski, Steven Z George, Susan M Tillman, Michael W Moser, Trevor A Lentz, Peter A Indelicato, Troy N Trumble, Jonathan J Shuster, Flavia M Cicuttini, Christiaan Leeuwenburgh
BACKGROUND: Plyometric exercise is used during rehabilitation after anterior cruciate ligament (ACL) reconstruction to facilitate the return to sports participation. However, clinical outcomes have not been examined, and high loads on the lower extremity could be detrimental to knee articular cartilage. PURPOSE: To compare the immediate effect of low- and high-intensity plyometric exercise during rehabilitation after ACL reconstruction on knee function, articular cartilage metabolism, and other clinically relevant measures...
March 2016: American Journal of Sports Medicine
Chantelle C Bozynski, James P Stannard, Pat Smith, Bryan T Hanypsiak, Keiichi Kuroki, Aaron Stoker, Cristi Cook, James L Cook
The objective of this study was to compare treatment options for acute management of anterior cruciate ligament (ACL) injuries using preclinical models. Twenty-seven adult purpose-bred research hounds underwent knee surgery (sham control, exposed ACL, or partial-tear ACL) and were assessed over the following 8 weeks. Dogs were randomized into three treatment groups: standard of care (i.e., rest and nonsteroidal anti-inflammatory drugs [NSAIDs]), washout, or leukoreduced platelet-rich plasma (PRP) so that a total of nine dogs received each treatment...
October 2016: Journal of Knee Surgery
Brian Pietrosimone, J Troy Blackburn, Matthew S Harkey, Brittney A Luc, Anthony C Hackney, Darin A Padua, Jeffrey B Driban, Jeffrey T Spang, Joanne M Jordan
BACKGROUND: Individuals who have sustained an anterior cruciate ligament (ACL) injury and undergo ACL reconstruction (ACLR) are at higher risk of developing knee osteoarthritis. It is hypothesized that altered knee loading may influence the underlying joint metabolism and hasten development of posttraumatic knee osteoarthritis. PURPOSE: To explore the associations between serum biomarkers of cartilage metabolism and peak vertical ground-reaction force (vGRF) and vGRF loading rate in the injured and uninjured limbs of individuals with ACLR...
February 2016: American Journal of Sports Medicine
Tangxin Liu, Zhongjun Yao, Mingwu He, Caixia Tian
BACKGROUND: Secondary osteoarthritis after ligament or meniscus injury generally causes great burdens to patients. Alpha-melanocyte-stimulating hormone (α-MSH ), a 13 amino acid neuropeptide produced by intracellular cleavage of the proopiomelanocortin (POMC) hormone, has been proven to suppress inflammation and protect cartilage from damage. The present study was carried out to explore the relationship between synovial fluid α-MSH levels and articular cartilage degeneration in patients with anterior cruciate ligament (ACL) deficiency...
2015: Clinical Laboratory
P-H Tsai, H-S Lee, T Y Siow, C-Y Wang, Y-C Chang, M-H Lin, Y-C Hsu, C-H Lee, H-W Chung, G-S Huang
OBJECTIVE: Although anterior cruciate ligament (ACL) injury is a well-recognized risk factor for developing knee post-traumatic osteoarthritis (PTOA), the process in the patellofemoral (PF) joint after ACL injury is still under-researched. Our aim was to investigate the perfusion changes in PF subchondral bone marrow in the rat ACL transection (ACLX) model of PTOA using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). DESIGN: Eighteen male Sprague Dawley rats were randomly separated into three groups (n = 6 each group): a normal control group and groups receiving ACLX and sham-surgery, respectively, in the right knee...
January 2016: Osteoarthritis and Cartilage
S Roberts, H Evans, K Wright, L van Niekerk, B Caterson, J B Richardson, K H S Kumar, J H Kuiper
OBJECTIVE: To evaluate the potential of ADAMTS-4 (aggrecanase -1) activity in synovial fluid (SF) as a biomarker of knee injury and joint disease. DESIGN: We have measured ADAMTS-4 activity in the synovial fluid of 170 orthopaedic patients with different degrees of joint pathology, using a commercial ADAMTS-4 fluorescence resonance energy transfer (FRET) substrate assay. Patients were classified at arthroscopy as (i) macroscopically normal, (ii) with an injury of the meniscus, anterior cruciate ligament or chondral/osteochondral defects or (iii) with osteoarthritis, and the influence of independent factors (age, patient group, effusion and synovial inflammation) on ADAMTS-4 activity levels was assessed...
September 2015: Osteoarthritis and Cartilage
Chao-Ying Wang, Ping-Huei Tsai, Tiing Yee Siow, Herng-Sheng Lee, Yue-Cune Chang, Yi-Chih Hsu, Shih-Wei Chiang, Ming-Huang Lin, Hsiao-Wen Chung, Guo-Shu Huang
The Hoffa fat pad (infrapatellar fat pad) is a source of post-traumatic anterior knee pain, and Hoffa disease is a syndrome leading to chronic inflammation of the fat pad. Herein, change in T2* relaxation time of the fat pad was measured in a rodent anterior cruciate ligament transection (ACLX) model in order to (i) examine the causal relationship of anterior cruciate ligament (ACL) deficiency and Hoffa disease and (ii) demonstrate the feasibility of using T2* as an imaging biomarker to monitor disease progression...
September 2015: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Farrah Monibi, Brandon L Roller, Aaron Stoker, Bridget Garner, Sonny Bal, James L Cook
Osteoarthritis (OA) is a costly and debilitating condition that is typically not diagnosed early enough to prevent progression of disease. The purpose of this study was to evaluate synovial fluid from knees with and without OA for potential markers of joint inflammation and degradation and to correlate these findings with radiographic severity of disease. With Institutional Review Board approval, synovial fluid samples were collected before the patient undergoing total knee arthroplasty. Control knees (n = 3) were patients younger than 30 years of age with no history of anterior cruciate ligament, posterior cruciate ligament, or meniscal injury, and no surgical history for either knee...
April 2016: Journal of Knee Surgery
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