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(Anterior cruciate ligament) AND biomarker

T Maerz, M Fleischer, M D Newton, A Davidson, M Salisbury, P Altman, M D Kurdziel, K Anderson, A Bedi, K C Baker
OBJECTIVE: Little is known regarding acute local and systemic processes following anterior cruciate ligament (ACL) rupture. No study has elucidated whether bone marrow-derived mesenchymal stem cells (MSCs) are mobilized into circulation and recruited to the injured joint. METHODS: In Part 1, Lewis rats were randomized to noninvasive ACL rupture (Rupture) or non-injured (Control) (n = 6/group). After 72 h, whole blood MSC concentration was assessed using flow cytometry...
March 8, 2017: Osteoarthritis and Cartilage
Pieter Van Dyck, Martijn Froeling, Eline De Smet, Pim Pullens, Michaël Torfs, Peter Verdonk, Jan Sijbers, Paul M Parizel, Ben Jeurissen
PURPOSE: A great need exists for objective biomarkers to assess graft healing following ACL reconstruction to guide the time of return to sports. The purpose of this study was to evaluate the feasibility and reliability of diffusion tensor imaging (DTI) to delineate the anterior cruciate ligament (ACL) graft and to investigate its diffusion properties using a clinical 3T scanner. MATERIALS AND METHODS: DTI of the knee (b = 0, 400, and 800 s/mm(2) , 10 diffusion directions, repeated 16 times for a total of 336 diffusion-weighted volumes) was performed at 3T in 17 patients between 3 and 7 months (mean, 4 months) following ACL reconstruction...
February 14, 2017: Journal of Magnetic Resonance Imaging: JMRI
Caroline Nw Wurtzel, Jonathan P Gumucio, Jeremy A Grekin, Roger K Khouri, Alan J Russell, Asheesh Bedi, Christopher L Mendias
Anterior cruciate ligament (ACL) tears are among the most frequent knee injuries in sports medicine, with tear rates in the US up to 250,000 per year. Many patients who suffer from ACL tears have persistent atrophy and weakness even after considerable rehabilitation. Myostatin is a cytokine that directly induces muscle atrophy, and previous studies rodent models and patients have demonstrated an upregulation of myostatin after ACL tear. Using a preclinical rat model, our objective was to determine if the use of a bioneutralizing antibody against myostatin could prevent muscle atrophy and weakness after ACL tear...
February 8, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Yu-Cong Zou, Liang-Hua Chen, Yong-Liang Ye, Guang-Gang Yang, Zheng Mao, Dan-Dan Liu, Jun-Qi Chen, Jing-Jie Chen, Gang Liu
BACKGROUND: The meniscus injury and post-traumatic knee osteoarthritis (PTOA) following anterior cruciate ligament (ACL) lesions often cause great burdens to patients. Ghrelin, a recently identified 28-amino-acid peptide, has been shown to inhibit inflammation and perform as a growth factor for chondrocyte. OBJECTIVE: This study was aimed at investigating ghrelin concentration in synovial fluid and its association with the degree of meniscus injury, articular degeneration, and clinical severity in patients suffering from anterior cruciate ligament (ACL) deficiency...
December 2016: Discovery Medicine
Christian Lattermann, Cale A Jacobs, Mary Proffitt Bunnell, Laura J Huston, Lee G Gammon, Darren L Johnson, Emily K Reinke, Janet L Huebner, Virginia B Kraus, Kurt P Spindler
BACKGROUND: It is increasingly recognized that biochemical abnormalities of the joint precede radiographic abnormalities of posttraumatic osteoarthritis (PTOA) by as much as decades. A growing body of evidence strongly suggests that the progression from anterior cruciate ligament (ACL) injury to PTOA is multifactorial, involving the interplay between biomechanical disturbances and biochemical homeostasis of articular cartilage. PURPOSE: The purposes of this randomized study using an acute ACL injury model were to (1) evaluate the natural progression of inflammatory and chondrodegenerative biomarkers, (2) evaluate the relationship between subjective reports of pain and inflammatory and chondrodegenerative biomarkers, and (3) determine if postinjury arthrocentesis and corticosteroid injection offer the ability to alter this biochemical cascade...
February 2017: American Journal of Sports Medicine
Daniel J Kaplan, Vanessa G Cuellar, Laith M Jazrawi, Eric J Strauss
PURPOSE: To establish how synovial fluid biomarker concentrations change in patients after anterior cruciate ligament (ACL) tears, with and without associated cartilage injury, with comparisons made to healthy controls. METHODS: Patients were prospectively enrolled between January 2013 and December 2014. Inclusion criteria included any patient undergoing knee arthroscopy. Patients with a confirmed ACL tear were allocated to either the ACL tear with cartilage injury group or the ACL tear without cartilage injury group based on intraoperative assessment...
January 24, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
Valentina Pedoia, Colin Russell, Allison Randolph, Xiaojuan Li, Sharmila Majumdar
BACKGROUND: Quantitative MR, including T1ρ mapping, has been extensively used to probe early biochemical changes in knee articular cartilage of subjects with osteoarthritis (OA) and others at risk for cartilage degeneration, such as those with anterior cruciate ligament (ACL) injury and reconstruction. However, limited studies have been performed aimed to assess the spatial location and patterns of T1ρ. In this study we used a novel voxel-based relaxometry (VBR) technique coupled with principal component analysis (PCA) to extract relevant features so as to describe regional patterns and to investigate their similarities and differences in T1ρ maps in subjects with OA and subjects six months after ACL reconstruction (ACLR)...
December 2016: Quantitative Imaging in Medicine and Surgery
Brett D Owens, Kenneth L Cameron, Steven L Bokshan, Kari B Clifton, Steven J Svoboda, Jennifer Moriatis Wolf
Differences in cartilage biomarkers have been noted in patients with anterior cruciate ligament tears, but little is known about any similar relationship with shoulder instability. This study evaluated the relationship between serum cartilage biomarkers and shoulder instability. The authors present a prospective cohort study of young athletes followed from 2006 to 2010. A nested case-control analysis was conducted within this cohort to evaluate the association between preinjury collagen type II cleavage (a marker for type II collagen cleavage) and procollagen II carboxy propeptide (a marker of cartilage synthesis) and the subsequent likelihood of shoulder instability during the 4-year follow-up period...
September 29, 2016: Orthopedics
(no author information available yet)
Svoboda SJ, Owens BD, Harvey TM, Tarwater PM, Brechue WF, Cameron KL. The association between serum biomarkers of collagen turnover and subsequent anterior cruciate ligament rupture. Am J Sports Med 2016;44(7):1687-1693. (Original DOI: 10.1177/0363546516640515)In the above article, the affiliation for Travis M. Harvey was incorrectly listed. The correct affiliation is United States Special Operations Command, MacDill Air Force Base, Florida, USA.
September 2016: American Journal of Sports Medicine
Jenna Le, Qi Peng, Karen Sperling
Osteoarthritis (OA) is a disease whose hallmark is the degeneration of articular cartilage. There is a worsening epidemic of OA in the United States today, with considerable economic costs. In order to develop more effective treatments for OA, noninvasive biomarkers that permit early diagnosis and treatment monitoring are necessary. T1rho and T2 mapping are two magnetic resonance imaging techniques that have shown great promise as noninvasive biomarkers of cartilage degeneration. Each of the two techniques is endowed with advantages and disadvantages: T1rho can discern earlier biochemical changes of OA than T2 mapping, while T2 mapping is more widely available and can be incorporated into existing imaging protocols in a more time-efficient manner than T1rho...
November 2016: Annals of the New York Academy of Sciences
Weilin Liu, Jian He, Ruhui Lin, Jie Liang, Qinglu Luo
The present study investigated the differential proteomics of synovial membranes between bilateral and unilateral anterior cruciate ligament transection (ACLT) in rabbits with knee osteoarthritis (KOA), in order to elucidate the pathological biomarkers of different degrees of KOA. A total of 6 New Zealand rabbits were randomly divided into groups A and B (three rabbits per group). The two groups were subjected to bilateral and unilateral ACLT, respectively. A total of 6 weeks following surgery, proteins were extracted from the knee joint synovial membranes of KOA rabbits and were separated by two‑dimensional polyacrylamide gel electrophoresis...
September 2016: Molecular Medicine Reports
Yonghui Dong, Hui Liu, Xuejun Zhang, Fei Xu, Liang Qin, Peng Cheng, Hui Huang, Fengjing Guo, Qing Yang, Anmin Chen
Previous studies showed that SDF-1α is a catabolic factor that can infiltrate cartilage, decrease proteoglycan content, and increase MMP-13 activity. Inhibiting the SDF-1α/CXCR4 signalling pathway can attenuate the pathogenesis of osteoarthritis (OA). Recent studies have also shown that SDF-1α enhances chondrocyte proliferation and maturation. These results appear to be contradictory. In the current study, we used a destabilisation OA animal model to investigate the effects of SDF-1α/CXCR4 signalling in the tibial subchondral bone and the OA pathological process...
June 16, 2016: International Journal of Molecular Sciences
Christian Lattermann, Cale A Jacobs, Mary Proffitt Bunnell, Kate N Jochimsen, John P Abt, Emily K Reinke, Lee G Gammon, Janet L Huebner, Virginia B Kraus, Kurt P Spindler
Anterior cruciate ligament (ACL) injuries are common and lead to posttraumatic osteoarthritis (PTOA) in a high percentage of patients. Research has been ineffective in identifying successful treatment options for people suffering from symptomatic PTOA resulting in a shift of focus toward the young, ACL injured patients at risk of developing PTOA. Randomized clinical trials examining the very early phase after ACL injury are ideal to study this population; however, these trials face significant challenges regarding recruitment as well as reproducibility of patient-reported outcomes (PROs) and inflammatory and/or chondrodegenerative biomarkers associated with early PTOA...
March 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Steven J Svoboda, Brett D Owens, Travis M Harvey, Patrick M Tarwater, William F Brechue, Kenneth L Cameron
BACKGROUND: No study has attempted to associate the levels of preinjury serum biomarkers of collagen turnover with the subsequent risk of anterior cruciate ligament (ACL) injury. HYPOTHESIS: Preinjury serum biomarkers of collagen turnover would be associated with the subsequent risk of ACL injury. STUDY DESIGN: Case-control study; Level of evidence, 3. METHODS: We conducted a case-control study with 45 ACL-injured cases and 45 controls matched for sex, age, height, and weight...
July 2016: American Journal of Sports Medicine
Jarred Kaiser, Michael F Vignos, Fang Liu, Richard Kijowski, Darryl G Thelen
BACKGROUND: The pathogenesis of osteoarthritis following anterior cruciate ligament (ACL) reconstruction is currently unknown. The study purpose was to leverage recent advances in quantitative and dynamic MRI to test the hypothesis that abnormal joint mechanics within four years of reconstruction is accompanied by evidence of early compositional changes in cartilage. METHODS: Static MR imaging was performed bilaterally on eleven subjects with an ACL reconstruction (1-4years post-surgery) and on twelve healthy subjects to obtain tibial cartilage thickness maps...
2016: Clinical Biomechanics
María Carmen Terencio, María Luisa Ferrándiz, María Carmen Carceller, Ramón Ruhí, Pere Dalmau, Josep Vergés, Eulàlia Montell, Anna Torrent, María José Alcaraz
CONTEXT: The efficacy of the combination chondroitin sulfate-glucosamine (CS-GlcN) in the treatment of knee osteoarthritis (OA) has been suggested in recent clinical studies. In vitro reports have also suggested anti-inflammatory and anti-resorptive effects of this combination. OBJECTIVE: The aim of this study was to characterize the effects of CS-GlcN on joint degradation in vivo including the assessment of inflammation and bone metabolism in a model of OA. MATERIALS AND METHODS: We have used the OA model induced by anterior cruciate ligament transection (ACLT) in ovariectomised rats...
April 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Nicole M Cattano, Jeffrey B Driban, Mary F Barbe, Ryan Tierney, Mamta Amin, Michael R Sitler
The purpose of this study was to determine whether an association existed between self-reported symptom and function scores and tissue turnover or inflammatory biomarker changes after a running bout among individuals with and without an acute knee-injury history. A pre-test/post-test prospective cohort study design (Level II) of 22 participants was conducted. Eleven physically active individuals with a history of anterior cruciate ligament surgery and/or meniscus surgery within 4 years of study participation were matched to 11 healthy control participants...
March 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Riann M Palmieri-Smith, Edward M Wojtys, Hollis G Potter
PURPOSE: To determine if magnetic resonance imaging markers of cartilage matrix and morphology and circulating serum biomarkers of inflammation and matrix degradation differ over time in patients with anterior cruciate ligament (ACL) injury and bone marrow edema lesions (BMELs) when compared with matched control subjects. METHODS: We performed a case-control study, in which 11 ACL-injured subjects scheduled to undergo reconstruction and 11 matched control subjects were scheduled for testing...
July 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
Terese L Chmielewski, Steven Z George, Susan M Tillman, Michael W Moser, Trevor A Lentz, Peter A Indelicato, Troy N Trumble, Jonathan J Shuster, Flavia M Cicuttini, Christiaan Leeuwenburgh
BACKGROUND: Plyometric exercise is used during rehabilitation after anterior cruciate ligament (ACL) reconstruction to facilitate the return to sports participation. However, clinical outcomes have not been examined, and high loads on the lower extremity could be detrimental to knee articular cartilage. PURPOSE: To compare the immediate effect of low- and high-intensity plyometric exercise during rehabilitation after ACL reconstruction on knee function, articular cartilage metabolism, and other clinically relevant measures...
March 2016: American Journal of Sports Medicine
Chantelle C Bozynski, James P Stannard, Pat Smith, Bryan T Hanypsiak, Keiichi Kuroki, Aaron Stoker, Cristi Cook, James L Cook
The objective of this study was to compare treatment options for acute management of anterior cruciate ligament (ACL) injuries using preclinical models. Twenty-seven adult purpose-bred research hounds underwent knee surgery (sham control, exposed ACL, or partial-tear ACL) and were assessed over the following 8 weeks. Dogs were randomized into three treatment groups: standard of care (i.e., rest and nonsteroidal anti-inflammatory drugs [NSAIDs]), washout, or leukoreduced platelet-rich plasma (PRP) so that a total of nine dogs received each treatment...
October 2016: Journal of Knee Surgery
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