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T1rho

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https://www.readbyqxmd.com/read/29329888/associations-between-cartilage-proteoglycan-density-and-patient-outcomes-12months-following-anterior-cruciate-ligament-reconstruction
#1
Brian Pietrosimone, Daniel Nissman, Darin A Padua, J Troy Blackburn, Matthew S Harkey, Robert A Creighton, Ganesh M Kamath, Kaitlin Healy, Randy Schmitz, Jeffrey B Driban, Steve W Marshall, Joanne M Jordan, Jeffrey T Spang
BACKGROUND: Lower proteoglycan density (PGD) of the articular cartilage may be an early marker of osteoarthritis following anterior cruciate ligament (ACL) reconstruction (ACL-R). The purpose this study was to determine associations between the Knee Injury and Osteoarthritis Outcomes Score (KOOS) and PGD of the articular cartilage in the femur and tibia 12-months following ACL-R. METHODS: We evaluated KOOS pain, symptoms, function in activities of daily living (ADL), function in sport and recreation (Sport), and quality of life (QOL), as well as PGD using T1rho magnetic resonance imaging in 18 individuals 12...
January 9, 2018: Knee
https://www.readbyqxmd.com/read/29322877/topographical-variation-of-human-femoral-articular-cartilage-thickness-t1rho-and-t2-relaxation-times-is-related-to-local-loading-during-walking
#2
Sam Van Rossom, Mariska Wesseling, Dieter Van Assche, Ilse Jonkers
Objective Early detection of degenerative changes in the cartilage matrix composition is essential for evaluating early interventions that slow down osteoarthritis (OA) initiation. T1rho and T2 relaxation times were found to be effective for detecting early changes in proteoglycan and collagen content. To use these magnetic resonance imaging (MRI) methods, it is important to document the topographical variation in cartilage thickness, T1rho and T2 relaxation times in a healthy population. As OA is partially mechanically driven, the relation between these MRI-based parameters and localized mechanical loading during walking was investigated...
January 1, 2018: Cartilage
https://www.readbyqxmd.com/read/29278765/gd-eob-dtpa-enhanced-t1%C3%AF-imaging-vs-diffusion-metrics-for-assessment-liver-inflammation-and-early-stage-fibrosis-of-nonalcoholic-steatohepatitis-in-rabbits
#3
Yuanliang Xie, Hongfeng Zhang, Chaoling Jin, Xiang Wang, Xiaoqi Wang, Jingting Chen, Yikai Xu
To assess the value of T1ρ,T1ρ on hepatobiliary phase (HBP) and diffusion metrics in staging of Non-alcoholic fatty liver disease (NAFLD) activity scores, inflammation, fibrosis in NASH rabbits model. Non-alcoholic steatohepatitis (NASH) rabbits model was induced by feeding a varied duration of high-fat, high-cholesterol diet. T1ρ,T1ρ (HBP) 20min after administration of Gd-EOB-DTPA, and Intravoxel incoherent motion imaging (IVIM) diffusion-weighted imaging were performed on a 3.0T magnetic resonance (MR) imaging unit...
December 23, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29241024/age-and-gender-associated-liver-physiological-t1rho-dynamics-demonstrated-with-a-clinically-applicable-single-breathhold-acquisition
#4
Yì Xiáng J Wáng, Min Deng, Jiang Lin, Anthony W L Kwok, Eric K W Liu, Weitian Chen
To understand women's and men's physiological ranges of liver T1rho relaxation time measured with a single breathhold black blood sequence, this healthy volunteer study was conducted in 62 women (mean age, 38.9 y; range, 18-75 y) and 34 men (mean age, 44.7 y; range, 24-80 y). Approval from the institutional ethics committee was obtained. Magnetic resonance imaging was performed with a 3.0T scanner with six spin-lock times of 0, 10, 20, 25, 35, and 50 ms and a single breathhold of 12 s per slice acquisition...
December 1, 2017: SLAS Technology
https://www.readbyqxmd.com/read/29184772/how-liver-pathologies-contribute-to-t1rho-contrast-require-more-careful-studies
#5
Yì Xiáng J Wáng, Weitian Chen, Min Deng
No abstract text is available yet for this article.
October 2017: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29109053/quantitative-assessment-of-liver-function-with-whole-liver-t1rho-mapping-at-3-0t
#6
Weibo Chen, Xin Chen, Li Yang, Guangbin Wang, Jianqi Li, Shanshan Wang, Queenie Chan, Dongrong Xu
OBJECTIVES: To assess the segmental liver function in healthy subjects and liver cirrhosis (LC) patients with different Child-Pugh grades using whole-liver T1rho mapping at 3.0T. METHODS: Thirty-three healthy volunteers and 33 patients with clinically diagnosed LC were examined using a three-dimensional (3D) whole-liver coverage T1rho mapping. T1rho maps were calculated from five respiratory-triggered sequences with different spin-lock durations (0, 10, 20, 40, and 60ms)...
November 3, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29103482/quantitative-evaluation-of-knee-cartilage-and-meniscus-destruction-in-patients-with-rheumatoid-arthritis-using-t1%C3%AF-and-t2-mapping
#7
Xiang Hong Meng, Zhi Wang, Li Guo, Xiu Chan Liu, Yu Wei Zhang, Ze Wei Zhang, Xin Long Ma
OBJECTIVE: To calculate T1ρ and T2 values of articular cartilage and menisci in knee joints of patients with RA, and compare the values between RA patients and healthy volunteers, to gain insight into the pathogenesis of cartilage and meniscus degradation in patients with RA. MATERIALS AND METHODS: Nine patients with RA and knee joints symptoms were enrolled in the study, twenty healthy volunteers without knee joint diseases were included as controls. Sagittal fat-saturated T1ρ and T2 mapping images were obtained on a 3T MR scanner (GE750, GE Healthcare, Waukesha, WI), using a dedicated 8-channel knee coil...
November 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/29089822/impact-of-liver-fibrosis-and-fatty-liver-on-t1rho-measurements-a-prospective-study
#8
Shuangshuang Xie, Qing Li, Yue Cheng, Yu Zhang, Zhizheng Zhuo, Guiming Zhao, Wen Shen
OBJECTIVE: To investigate the liver T1rho values for detecting fibrosis, and the potential impact of fatty liver on T1rho measurements. MATERIALS AND METHODS: This study included 18 healthy subjects, 18 patients with fatty liver, and 18 patients with liver fibrosis, who underwent T1rho MRI and mDIXON collections. Liver T1rho, proton density fat fraction (PDFF) and T2* values were measured and compared among the three groups. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the T1rho values for detecting liver fibrosis...
November 2017: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/28829171/advanced-imaging-techniques-of-the-wrist
#9
REVIEW
Andrew L Chang, Hon J Yu, Donald von Borstel, Taiki Nozaki, Saya Horiuchi, Yasuhiko Terada, Hiroshi Yoshioka
OBJECTIVE: This article covers the technical aspects and clinical applications of recent advancements in wrist MRI techniques, including T2 and T1rho mapping, compressed sensing, and isotropic 3D imaging using driven equilibrium sequences, variable-flip-angle refocusing pulse sequences, and parallel imaging. The clinical applications of these techniques include the quantitative analysis of cartilage and triangular fibrocartilaginous complex (TFCC) degeneration, faster scanning times, and improved resolution of complex wrist anatomy, allowing differentiation of degenerative from traumatic TFCC tears and improved morphologic evaluation of chondromalacia...
September 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28679324/breath-hold-black-blood-t1rho-mapping-improves-liver-t1rho-quantification-in-healthy-volunteers
#10
Yì Xiáng J Wáng, Min Deng, Gladys G Lo, Dong Liang, Jing Yuan, Weitian Chen
Background Recent researches suggest that T1rho may be a non-invasive and quantitative technique for detecting and grading liver fibrosis. Purpose To compare a multi-breath-hold bright-blood fast gradient echo (GRE) imaging and a single breath-hold single-shot fast spin echo (FSE) imaging with black-blood effect for liver parenchyma T1rho measurement and to study liver physiological T1rho value in healthy volunteers. Material and Methods The institutional Ethics Committee approved this study. 28 healthy participants (18 men, 10 women; age = 29...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28629576/differentiation-of-brain-tumor-related-edema-based-on-3d-t1rho-imaging
#11
J E Villanueva-Meyer, R F Barajas, M C Mabray, W Chen, A Shankaranarayanan, P Koon, I J Barani, T Tihan, S Cha
BACKGROUND AND PURPOSE: Cerebral edema associated with brain tumors is an important source of morbidity. Its type depends largely on the capillary ultra-structures of the histopathologic subtype of underlying brain tumor. The purpose of our study was to differentiate vasogenic edema associated with brain metastases and infiltrative edema related to diffuse gliomas using quantitative 3D T1 rho (T1ρ) imaging. MATERIALS AND METHODS: Preoperative MR examination including whole brain 3D T1ρ imaging was performed in 23 patients with newly diagnosed brain tumors (9 with metastasis, 8 with lower grade glioma, LGG, 6 with glioblastoma, GBM)...
June 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28521823/t1rho-and-t2-relaxation-times-of-the-normal-adult-knee-meniscus-at-3t-analysis-of-zonal-differences
#12
Shoichiro Takao, Tan B Nguyen, Hon J Yu, Shigeo Hagiwara, Yasuhito Kaneko, Taiki Nozaki, Seiji Iwamoto, Maki Otomo, Ran Schwarzkopf, Hiroshi Yoshioka
BACKGROUND: Prior studies describe histological and immunohistochemical differences in collagen and proteoglycan content in different meniscal zones. The aim of this study is to evaluate horizontal and vertical zonal differentiation of T1rho and T2 relaxation times of the entire meniscus from volunteers without symptom and imaging abnormality. METHODS: Twenty volunteers age between 19 and 38 who have no knee-related clinical symptoms, and no history of prior knee surgeries were enrolled in this study...
May 18, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28237185/relationship-between-t1rho-magnetic-resonance-imaging-synovial-fluid-biomarkers-and-the-biochemical-and-biomechanical-properties-of-cartilage
#13
Courtney C Hatcher, Amber T Collins, Sophia Y Kim, Lindsey C Michel, William C Mostertz, Sophia N Ziemian, Charles E Spritzer, Farshid Guilak, Louis E DeFrate, Amy L McNulty
Non-invasive techniques for quantifying early biochemical and biomechanical changes in articular cartilage may provide a means of more precisely assessing osteoarthritis (OA) progression. The goals of this study were to determine the relationship between T1rho magnetic resonance (MR) imaging relaxation times and changes in cartilage composition, cartilage mechanical properties, and synovial fluid biomarker levels and to demonstrate the application of T1rho imaging to evaluate cartilage composition in human subjects in vivo...
April 11, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28161394/magic-angle-effect-plays-a-major-role-in-both-t1rho-and-t2-relaxation-in-articular-cartilage
#14
H Shao, C Pauli, S Li, Y Ma, A S Tadros, A Kavanaugh, E Y Chang, G Tang, J Du
PURPOSE: To investigate the effect of sample orientation on T1rho and T2 values of articular cartilage in histologically confirmed normal and abnormal regions using a whole-body 3T scanner. MATERIALS AND METHODS: Eight human cadaveric patellae were evaluated using a 2D CPMG sequence for T2 measurement as well as a 2D spin-locking prepared spiral sequence and a 3D magnetization-prepared angle-modulated partitioned-k-space spoiled gradient echo snapshots (3D MAPSS) sequence for T1rho measurement...
February 1, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27937040/multiparametric-or-practical-quantitative-liver-mri-towards-millisecond-fat-fraction-kilopascal-and-function-era
#15
REVIEW
Emre Unal, Ilkay Sedakat Idilman, Muşturay Karçaaltıncaba
New advances in liver magnetic resonance imaging (MRI) may enable diagnosis of unseen pathologies by conventional techniques. Normal T1 (550-620 ms for 1.5 T and 700-850 ms for 3 T), T2, T2* (>20 ms), T1rho (40-50 ms) mapping, proton density fat fraction (PDFF) (≤5%) and stiffness (2-3kPa) values can enable differentiation of a normal liver from chronic liver and diffuse diseases. Gd-EOB-DTPA can enable assessment of liver function by using postcontrast hepatobiliary phase or T1 reduction rate (normally above 60%)...
February 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27833407/comparison-of-t1rho-and-t2-mapping-of-knee-articular-cartilage-in-an-asymptomatic-population
#16
COMPARATIVE STUDY
Min A Yoon, Suk-Joo Hong, A Lan Im, Chang Ho Kang, Baek Hyun Kim, In Seong Kim
OBJECTIVE: To analyze subregional differences in T1rho (T1ρ) and T2 values and their correlation in asymptomatic knee cartilage, and to evaluate angular dependence with magic angles. MATERIALS AND METHODS: Six asymptomatic volunteers underwent knee MRI with T1ρ and T2 mapping. T1ρ and T2 values were measured by two radiologists independently, at nine subregions in the medial femoral condyle (MFC) cartilage, at angles of ± 0°, 15°, 35°, 55°, 75° respective to a vertical line (B0) bisecting the width of the distal femur, and at two locations in the patella...
November 2016: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/27824671/early-changes-of-irradiated-parotid-glands-evaluated-by-t1rho-weighted-imaging-a-pilot-study
#17
Nan Zhou, Chen Chu, Xin Dou, Ming Li, Song Liu, Tingting Guo, Lijing Zhu, Baorui Liu, Weibo Chen, Jian He, Jing Yan, Zhengyang Zhou, Xiaofeng Yang
OBJECTIVE: The aim of the study was to confirm the feasibility of T1rho-weighted imaging to evaluate the dynamic changes of parotid glands in patients with nasopharyngeal carcinoma (NPC) undergoing intensity-modulated radiation therapy. METHODS: Twenty-six NPC patients (19 men; 7 women; mean [SD] age, 48.9 [13.4] years) underwent the following 3 serial T1rho-weighted imaging: within 2 weeks before radiotherapy (RT, pre-RT), 5 weeks after the beginning of RT (mid-RT), and 4 weeks after RT (post-RT)...
May 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/27709071/black-blood-t1rho-mr-imaging-may-diagnose-early-stage-liver-fibrosis-a-proof-of-principle-study-with-rat-biliary-duct-ligation-model
#18
Chi-Man Koon, Xin Zhang, Weitian Chen, Eagle Siu Hong Chu, Clara Bik San Lau, Yì-Xiáng J Wáng
BACKGROUND: To explore black blood T1rho (T1ρ) liver imaging and investigate the earliest stage when biliary duct ligation (BDL) induced liver fibrosis can be diagnosed. METHODS: MR was performed at 3 Tesla. A T1ρ prepared 2D fast spin echo (FSE) sequence with acquisition of four spin lock times (TSLs: 1, 10, 30, and 50 msec) and spin-lock frequency of 500 Hz was applied. Inherent black blood effect of FSE and double inversion recovery (DIR) achieved blood signal suppression, and 3 axial sections per liver were obtained...
August 2016: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/27599046/ultrashort-echo-time-magnetization-transfer-ute-mt-imaging-and-modeling-magic-angle-independent-biomarkers-of-tissue-properties
#19
Ya-Jun Ma, Hongda Shao, Jiang Du, Eric Y Chang
MRI biomarkers such as T2 , T2 * and T1rho have been widely used, but are confounded by the magic angle effect. The purpose of this study is to investigate the use of the two-dimensional ultrashort echo time magnetization transfer (UTE-MT) sequence for potential magic angle independent MR biomarkers. Magnetization transfer was investigated in cadaveric Achilles tendon samples using the UTE-MT sequence at five MT powers and five frequency offsets ranging from 2 to 50 kHz. The protocol was applied at five sample orientations ranging from 0 to 90° relative to the B0 field...
November 2016: NMR in Biomedicine
https://www.readbyqxmd.com/read/27527587/comparison-of-t2-t1rho-and-diffusion-metrics-in-assessment-of-liver-fibrosis-in-rats
#20
Hui Zhang, Qihua Yang, Taihui Yu, Xiaodong Chen, Jingwen Huang, Cui Tan, Biling Liang, Hua Guo
PURPOSE: To evaluate the value of T2 , T1 rho, and diffusion metrics in assessment of liver fibrosis in rats. MATERIALS AND METHODS: Liver fibrosis in a rat model (n = 72) was induced by injection of carbon tetrachloride (CCl4 ) at 3T. T2 , T1 rho, and diffusion parameters (apparent diffusion coefficient (ADC), Dtrue ) via spin echo (SE) diffusion-weighted imaging (DWI) and stimulated echo acquisition mode (STEAM) DWI with three diffusion times (DT: 80, 106, 186 msec) were obtained in surviving rats with hepatic fibrosis (n = 52) and controls (n = 8)...
August 16, 2016: Journal of Magnetic Resonance Imaging: JMRI
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