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stress and cardiac death

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https://www.readbyqxmd.com/read/29458045/aldose-reductase-inhibitor-fidarestat-prevents-doxorubicin-induced-endothelial-cell-death-and-dysfunction
#1
Himangshu Sonowal, Pabitra Pal, Kirtikar Shukla, Ashish Saxena, Satish K Srivastava, Kota V Ramana
Despite doxorubicin (Dox) being one of the most widely used chemotherapy agents for breast, blood and lung cancers, its use in colon cancer is limited due to increased drug resistance and severe cardiotoxic side effects that increase mortality associated with its use at high doses. Therefore, better adjuvant therapies are warranted to improve the chemotherapeutic efficacy and to decrease cardiotoxicity. We have recently shown that aldose reductase inhibitor, fidarestat, increases the Dox-induced colon cancer cell death and reduces cardiomyopathy...
February 16, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29444190/bone-marrow-mesenchymal-stem-cell-derived-exosomal-mir-21-protects-c-kit-cardiac-stem-cells-from-oxidative-injury-through-the-pten-pi3k-akt-axis
#2
Bei Shi, Yan Wang, Ranzhun Zhao, Xianping Long, Wenwen Deng, Zhenglong Wang
Stem cell (SC) therapy for ischemic cardiomyopathy is hampered by poor survival of the implanted cells. Recently, SC-derived exosomes have been shown to facilitate cell proliferation and survival by transporting various proteins and non-coding RNAs (such as microRNAs and lncRNAs). In this study, miR-21 was highly enriched in exosomes derived from bone marrow mesenchymal stem cells (MSCs). Interestingly, exosomes collected from hydrogen peroxide (H2O2)-treated MSCs (H-Exo) contained higher levels of miR-21 than exosomes released from MSCs under normal conditions (N-Exo)...
2018: PloS One
https://www.readbyqxmd.com/read/29439404/high-fat-diet-induced-obesity-produces-spontaneous-ventricular-arrhythmias-and-increases-the-activity-of-ryanodine-receptors-in-mice
#3
Gina Sánchez, Felipe Araneda, Juan Pedro Peña, José Pablo Finkelstein, Jaime A Riquelme, Luis Montecinos, Genaro Barrientos, Paola Llanos, Zully Pedrozo, Matilde Said, Ricardo Bull, Paulina Donoso
Ventricular arrhythmias are a common cause of sudden cardiac death, and their occurrence is higher in obese subjects. Abnormal gating of ryanodine receptors (RyR2), the calcium release channels of the sarcoplasmic reticulum, can produce ventricular arrhythmias. Since obesity promotes oxidative stress and RyR2 are redox-sensitive channels, we investigated whether the RyR2 activity was altered in obese mice. Mice fed a high fat diet (HFD) became obese after eight weeks and exhibited a significant increase in the occurrence of ventricular arrhythmias...
February 10, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29433517/quality-of-life-of-patients-with-first-time-ami-a-descriptive-study
#4
Mandreker Bahall, Katija Khan
BACKGROUND: Outcomes following acute myocardial infarction (AMI) may result in death, increased morbidity, and change in quality of life (QOL). This study explores health-related QOL of first-time patients following AMI. METHODS: This cross-sectional study used a sample of patients with first-time AMI experienced between April 2011 and March 2015 at a tertiary health institution. Recruited patients belonged to different post-AMI periods: 2-10 weeks, 5-22 months, and > 22 months to 4 years post AMI...
February 13, 2018: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29432369/implementation-of-an-early-discharge-protocol-and-chest-pain-clinic-for-low-risk-chest-pain-in-the-emergency-department
#5
Mohammad Amin Kashef, Jane Garb, Aaron Kugelmass, Amir Lotfi
BACKGROUND: Most of the patients presenting to emergency department with chest pain are at low risk of adverse events. Identifying high-risk patients can be challenging and resource intensive. METHODS: We created a protocol to assist early discharge of low-risk adults with chest pain from emergency department. Also a chest pain clinic (CPC) was started for cardiology follow-up within 72 hours. In a retrospective cohort study, primary outcome of major adverse cardiac events (MACEs) of death, myocardial infarction, or revascularization was compared between CPC patients and those hospitalized for observation...
March 2018: Critical Pathways in Cardiology
https://www.readbyqxmd.com/read/29431384/cardiomyopathy-an-overview
#6
Jay Brieler, Matthew A Breeden, Jane Tucker
The definition and classification of cardiomyopathy have evolved considerably in recent years. Cardiomyopathy can be separated into primary (genetic, mixed, or acquired) and secondary categories, which result in varied phenotypes including dilated, hypertrophic, and restrictive patterns. Hypertrophic cardiomyopathy is the most common primary cardiomyopathy and can cause exertional dyspnea, presyncope, atypical chest pain, heart failure, and sudden cardiac death. Dilated cardiomyopathy can be genetic or acquired and typically presents with classic symptoms of heart failure with reduced ejection fraction...
November 15, 2017: American Family Physician
https://www.readbyqxmd.com/read/29431371/palpitations-evaluation-in-the-primary-care-setting
#7
Randell K Wexler, Adam Pleister, Subha V Raman
Palpitations are a common problem in the ambulatory primary care setting, and cardiac causes are the most concerning etiology. Psychiatric illness, adverse effects of prescription and over-the-counter medications, and substance use should also be considered. Distinguishing cardiac from noncardiac causes is important because of the risk of sudden death in those with an underlying cardiac etiology. A thorough history and physical examination, followed by targeted diagnostic testing, can distinguish cardiac conditions from other causes of palpitations...
December 15, 2017: American Family Physician
https://www.readbyqxmd.com/read/29426649/rest-and-stress-longitudinal-systolic-left-ventricular-mechanics-in-hypertrophic-cardiomyopathy-implications-for-prognostication
#8
Iraklis Pozios, Aurelio Pinheiro, Celia Corona-Villalobos, Lars L Sorensen, Zeina Dardari, Hong-Yun Liu, Kenneth Cresswell, Susan Phillip, David A Bluemke, Stefan L Zimmerman, M Roselle Abraham, Theodore P Abraham
BACKGROUND: Exercise intolerance is the most common symptom in hypertrophic cardiomyopathy (HCM). We examined whether inability to augment myocardial mechanics during exercise would influence functional performance and clinical outcomes in HCM. METHODS: Ninety-five HCM patients (32 nonobstructive, 32 labile-obstructive, 31 obstructive) and 26 controls of similar age and gender distribution were recruited prospectively. They underwent rest and treadmill stress strain echocardiography, and 61 of them underwent magnetic resonance imaging...
February 6, 2018: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/29423064/melatonin-attenuated-brain-death-tissue-extract-induced-cardiac-damage-by-suppressing-damp-signaling
#9
Pei-Hsun Sung, Fan-Yen Lee, Ling-Chun Lin, Kuan-Hung Chen, Hung-Sheng Lin, Pei-Lin Shao, Yi-Chen Li, Yi-Ling Chen, Kun-Chen Lin, Chun-Man Yuen, Hsueh-Wen Chang, Mel S Lee, Hon-Kan Yip
We tested the hypothesis that melatonin prevents brain death (BD) tissue extract (BDEX)-induced cardiac damage by suppressing inflammatory damage-associated molecular pattern (DAMP) signaling in rats. Six hours after BD induction, levels of a DAMP component (HMGB1) and inflammatory markers (TLR-2, TLR-4, MYD88, IκB, NF-κB, IL-1β, IFN-γ, TNF-α and IL-6) were higher in brain tissue from BD animals than controls. Levels of HMGB1 and inflammatory markers were higher in BDEX-treated H9C2 cardiac myoblasts than in cells treated with healthy brain tissue extract...
January 9, 2018: Oncotarget
https://www.readbyqxmd.com/read/29421400/exploring-links-between-greenspace-and-sudden-unexpected-death-a-spatial-analysis
#10
Jianyong Wu, Kristen M Rappazzo, Ross J Simpson, Golsa Joodi, Irion W Pursell, J Paul Mounsey, Wayne E Cascio, Laura E Jackson
Greenspace has been increasingly recognized as having numerous health benefits. However, its effects are unknown concerning sudden unexpected death (SUD), commonly referred to as sudden cardiac death, which constitutes a large proportion of mortality in the United States. Because greenspace can promote physical activity, reduce stress and buffer air pollutants, it may have beneficial effects for people at risk of SUD, such as those with heart disease, hypertension, and diabetes mellitus. Using several spatial techniques, this study explored the relationship between SUD and greenspace...
February 5, 2018: Environment International
https://www.readbyqxmd.com/read/29419761/a-kinase-anchoring-protein-lbc-a-molecular-scaffold-involved-in-cardiac-protection
#11
REVIEW
Dario Diviani, Halima Osman, Erica Reggi
Heart failure is a lethal disease that can develop after myocardial infarction, hypertension, or anticancer therapy. In the damaged heart, loss of function is mainly due to cardiomyocyte death and associated cardiac remodeling and fibrosis. In this context, A-kinase anchoring proteins (AKAPs) constitute a family of scaffolding proteins that facilitate the spatiotemporal activation of the cyclic adenosine monophosphate (AMP)-dependent protein kinase (PKA) and other transduction enzymes involved in cardiac remodeling...
February 8, 2018: Journal of Cardiovascular Development and Disease
https://www.readbyqxmd.com/read/29416617/low-dose-radiation-prevents-doxorubicin-induced-cardiotoxicity
#12
Xin Jiang, Yaqiong Hong, Di Zhao, Xinxin Meng, Lijing Zhao, Yanwei Du, Zan Wang, Yan Zheng, Lu Cai, Hongyu Jiang
This study aimed to develop a novel and non-invasive approach, low-dose radiation (LDR, 75 mGy X-rays), to prevent doxorubicin (DOX)-induced cardiotoxicity. BALB/c mice were randomly divided into five groups, Control, LDR (a single exposure), Sham (treated same as LDR group except for irradiation), DOX (a single intraperitoneal injection of DOX at 7.5 mg/kg), and LDR/DOX (received LDR and 72 h later received DOX). Electrocardiogram analysis displayed several kinds of abnormal ECG profiles in DOX-treated mice, but less in LDR/DOX group...
January 2, 2018: Oncotarget
https://www.readbyqxmd.com/read/29408371/women-in-danger-detecting-coronary-artery-disease-are-there-any-sex-differences
#13
EDITORIAL
A P Patrianakos
Cardiovascular disease (CVD) is the leading cause of death in women in the western countries. Women are less likely to seek medical assistance and are often misdiagnosed, facts that increase incrementally their CVD mortality. Exercise stress test is often non diagnostic and thus dobutamine stress echocardiography represents an excellent tool in the evaluation of coronary artery disease in women. Especially with the additional use of echocardiographic contrast agents that help to overcome the technical difficulties in the evaluation of the female small,usually, cardiac chambers, dobutamine stress echocardiography seems to be the most attractive non-invasive, radiation free diagnostic imaging modality, in the daily clinical practice with a proven diagnostic and prognostic value...
February 3, 2018: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/29398015/mitochondrial-oxidative-stress-and-cardiac-ageing
#14
Beatriz Martín-Fernández, Ricardo Gredilla
According with different international organizations, cardiovascular diseases are becoming the first cause of death in western countries. Although exposure to different risk factors, particularly those related to lifestyle, contribute to the etiopathogenesis of cardiac disorders, the increase in average lifespan and aging are considered major determinants of cardiac diseases events. Mitochondria and oxidative stress have been pointed out as relevant factors both in heart aging and in the development of cardiac diseases such as heart failure, cardiac hypertrophy and diabetic cardiomyopathy...
February 2, 2018: Clínica e Investigación en Arteriosclerosis
https://www.readbyqxmd.com/read/29385043/interplay-between-ros-and-antioxidants-during-ischemia-reperfusion-injuries-in-cardiac-and-skeletal-muscle
#15
REVIEW
Tingyang Zhou, Evan R Prather, Davis E Garrison, Li Zuo
Ischemia reperfusion (IR), present in myocardial infarction or extremity injuries, is a major clinical issue and leads to substantial tissue damage. Molecular mechanisms underlying IR injury in striated muscles involve the production of reactive oxygen species (ROS). Excessive ROS accumulation results in cellular oxidative stress, mitochondrial dysfunction, and initiation of cell death by activation of the mitochondrial permeability transition pore. Elevated ROS levels can also decrease myofibrillar Ca2+ sensitivity, thereby compromising muscle contractile function...
January 31, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29384387/racial-differences-in-dietary-antioxidant-intake-and-cardiac-event-free-survival-in-patients-with-heart-failure
#16
Jia-Rong Wu, Eun Kyeung Song, Debra K Moser, Terry A Lennie
BACKGROUND: Heart failure is a chronic, burdensome condition with higher re-hospitalization rates in African Americans than Whites. Higher dietary antioxidant intake is associated with lower oxidative stress and improved endothelial function. Lower dietary antioxidant intake in African Americans may play a role in the re-hospitalization disparity between African American and White patients with heart failure. OBJECTIVE: The objective of this study was to examine the associations among race, dietary antioxidant intake, and cardiac event-free survival in patients with heart failure...
January 1, 2018: European Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/29383439/impact-of-generalized-anxiety-disorder-gad-on-prehospital-delay-of-acute-myocardial-infarction-patients-findings-from-the-multicenter-medea-study
#17
X Y Fang, D Spieler, L Albarqouni, J Ronel, K-H Ladwig
BACKGROUND: Anxiety has been identified as a cardiac risk factor. However, less is known about the impact of generalized anxiety disorder (GAD) on prehospital delay during an acute myocardial infarction (AMI). This study assessed the impact of GAD on prehospital delay and delay related cognition and behavior. METHODS: Data were from the cross-sectional Munich examination of delay in patients experiencing acute myocardial infarction (MEDEA) study with a total of 619 ST-elevated myocardial infarction (STEMI) patients...
January 30, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29381985/sudden-cardiac-death-owing-to-arrhythmogenic-right-ventricular-cardiomyopathy-two-case-reports-and-systematic-literature-review
#18
Jiao Mu, Guohui Zhang, Dazhong Xue, Mengrou Xi, Jiarui Qi, Hongmei Dong
BACKGROUND AND OBJECTIVE: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is increasingly recognized in forensic practice with controversial diagnosis. Here we described the epidemiological characteristics and reported the pathogenetic mechanism, diagnostic challenges, and forensic implications of Chinese ARVC autopsy cases. METHODS: Two cases of sudden cardiac death owing to ARVC were reported. Retrospective analysis were performed on such 2 cases and 45 cases of separate ARVC complete autopsy case reports through Chinese literature databases in the last 30 years...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29381962/effects-of-treatment-with-chemotherapy-and-or-tamoxifen-on-the-biomarkers-of-cardiac-injury-and-oxidative-stress-in-women-with-breast-cancer
#19
Fabricio Bragança Silva, Walckiria Garcia Romero, Ana Ligia Rodrigues de Abreu Carvalho, Gleyce Ariadne Alves Souza, Erick Roberto Gonçalves Claudio, Glaucia Rodrigues Abreu
There has been an increase in deaths from cardiovascular diseases following breast cancer therapy. Evidence has shown that this outcome is, in part, associated with cardiotoxicity induced by the chemotherapeutic drugs and the increase in oxidative stress. The aim of this study was to evaluate the effects of chemotherapy and hormone therapy with tamoxifen on the biomarkers of cardiac injury and oxidative stress in women with breast cancer.Thirty women were followed-up for 1 year and were divided into 3 groups according to the treatment protocol: women treated only with tamoxifen and clinical follow up for 12 months (Tam, n = 10); women treated only with chemotherapy for 6 months with clinical follow up for an additional 6-month period (Chemo, n = 10); and women who received chemotherapy for 6 months followed by a 6-month period only with tamoxifen therapy and clinical follow up (Chemo + Tam, n = 10)...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29373667/experimental-ex-vivo-lung-perfusion-with-sevoflurane-effects-on-damaged-donor-lung-grafts
#20
Xingyu Wang, Roumen Parapanov, Cyril Francioli, Jean Yannis Perentes, Igor Letovanec, Michel Gonzalez, Christian Kern, Hans-Beat Ris, Lise Piquilloud, Carlo Marcucci, Thorsten Krueger, Lucas Liaudet, Fabrizio Gronchi
OBJECTIVES: Volatile anaesthetics can provide significant protection against reperfusion injury in various experimental settings. The aim of this study was to assess the potential of sevoflurane treatment, the most commonly used volatile anaesthetic in modern anaesthesia, in rat lungs donated after circulatory death and reconditioned in an ex vivo lung perfusion (EVLP) system. METHODS: Fifteen rats were sacrificed and divided into 3 groups. In the control and sevoflurane groups, the heart-lung blocks were exposed to 1 h of warm ischaemia and 2 h of cold ischaemia and were mounted on an EVLP circuit for 3 h, in the absence or in the presence of 2% sevoflurane...
January 24, 2018: Interactive Cardiovascular and Thoracic Surgery
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