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https://www.readbyqxmd.com/read/29664663/effects-of-probiotic-supplementation-on-hormonal-profiles-biomarkers-of-inflammation-and-oxidative-stress-in-women-with-polycystic-ovary-syndrome-a-randomized-double-blind-placebo-controlled-trial
#1
Maryam Karamali, Sara Eghbalpour, Sajad Rajabi, Mehri Jamilian, Fereshteh Bahmani, Maryam Tajabadi-Ebrahimi, Fariba Keneshlou, Seyyed Mehdi Mirhashemi, Maryam Chamani, Sara Hashem Gelougerdi, Zatollah Asemi
BACKGROUND: To the best of our knowledge, data on effects of probiotic administration on hormonal profiles, biomarkers of inflammation and oxidative stress in women with polycystic ovary syndrome (PCOS) are scarce. This investigation was conducted to assess the effects of probiotic supplementation on hormonal profiles, biomarkers of inflammation and oxidative stress in women with PCOS. METHODS: This randomized, double-blind, placebo-controlled trial was conducted on 60 women with PCOS, aged 18-40 years old...
January 1, 2018: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/29663635/di-2-ethylhexyl-phthalate-dehp-induced-testicular-toxicity-through-nrf2-mediated-notch1-signaling-pathway-in-sprague-dawley-rats
#2
Xiangliang Tang, Shengde Wu, Lianju Shen, Yi Wei, Xining Cao, Yangcai Wang, Chunlan Long, Yue Zhou, Dian Li, Fangyuan Huang, Bo Liu, Guanghui Wei
Di-(2-ethylhexyl) phthalate (DEHP) is an environmental endocrine disruptor widely used in China that is harmful to the male reproductive system. Many studies have shown that DEHP causes testicular toxicity through oxidative stress, but the specific mechanism is unknown. Because the Notch pathway is a key mechanism for regulating cell growth and proliferation, we investigated whether Notch is involved in DEHP-induced testicular toxicity and whether vitamins E and C could rescue testicular impairment in Sprague-Dawley (SD) rats...
April 16, 2018: Environmental Toxicology
https://www.readbyqxmd.com/read/29642620/rhodobacter-sphaeroides-extract-lycogen%C3%A2-attenuates-testosterone-induced-benign-prostate-hyperplasia-in-rats
#3
Chiang-Ting Wang, Ya-Yun Wang, Wen-Sheng Liu, Chun-Ming Cheng, Kuo-Hsun Chiu, Li-Lian Liu, Xue-Zhu Liu, Zhi-Hong Wen, Ya-Huey Chen, Tsung-Ming Chen
Benign prostate hyperplasia (BPH) is one of the most common urological problems in mid-aged to elderly men. Risk factors of BPH include family history, obesity, type 2 diabetes, and high oxidative stress. The main medication classes for BPH management are alpha blockers and 5α-reductase inhibitors. However, these conventional medicines cause adverse effects. Lycogen™, extracted from Rhodobacter sphaeroides WL-APD911, is an anti-oxidant and anti-inflammatory compound. In this study, the effect of Lycogen™ was evaluated in rats with testosterone-induced benign prostate hyperplasia (BPH)...
April 10, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29627396/characterization-of-circulating-steroid-hormone-profiles-in-the-bottlenose-dolphin-tursiops-truncatus-by-liquid-chromatography-tandem-mass-spectrometry-lc-ms-ms
#4
Thomas M Galligan, Lori H Schwacke, Dorian S Houser, Randall S Wells, Teri Rowles, Ashley S P Boggs
Systemic steroid hormone measurements are often used in the assessment of reproductive, developmental, and stress physiology in vertebrates. In protected wildlife, such as the common bottlenose dolphin (Tursiops truncatus), these measures can provide critical information about health and fitness to aid in effective conservation and management. Circulating steroid hormone concentrations are typically measured by immunoassays, which have imperfect specificity and are limited to the measurement of a single hormone per assay...
April 5, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29623697/efficacy-and-safety-of-a-mixed-extract-of-trigonella-foenum-graecum-seed-and-lespedeza-cuneata-in-the-treatment-of-testosterone-deficiency-syndrome-a-randomized-double-blind-placebo-controlled-clinical-trial
#5
Hyun Jun Park, Kyeong Soo Lee, Eun Kyoung Lee, Nam Cheol Park
PURPOSE: The aim of this study was to investigate the efficacy and safety of a mixed extract of Trigonella foenum-graecum seed and Lespedeza cuneata (TFGL) for the treatment of testosterone deficiency syndrome (TDS). MATERIALS AND METHODS: Patients were instructed to take a placebo or 200 mg TFGL capsule twice per day for 8 weeks. The primary efficacy variable was the change from baseline in the Aging Males' Symptoms scale (AMS), as well as levels of serum total and free testosterone...
March 22, 2018: World Journal of Men's Health
https://www.readbyqxmd.com/read/29621673/part-b-morphometric-and-transcriptomic-responses-to-sub-chronic-exposure-to-the-polycyclic-aromatic-hydrocarbon-phenanthrene-in-the-fathead-minnow-pimephales-promelas
#6
Jennifer R Loughery, Karen A Kidd, Angella Mercer, Chris J Martyniuk
Phenanthrene is a tricyclic polycyclic aromatic hydrocarbon and environmental contaminant found in high concentrations around urban catchments and in the vicinity of oil extraction activities. Fish exposed to phenanthrene can exhibit altered reproductive hormone profiles and/or differences within gonadosomatic index and altered gamete proportions, but the mechanisms underlying these changes are not fully understood. In this study, we conducted a sub-chronic bioassay and measured transcriptional responses in the liver, the major tissue involved in generating lipids for oocyte growth...
March 23, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29613814/grape-seed-procyanidins-extract-attenuates-cisplatin-induced-oxidative-stress-and-testosterone-synthase-inhibition-in-rat-testes
#7
Minmin Tian, Fangfang Liu, Han Liu, Qiong Zhang, Lei Li, Xiangbo Hou, Jianxin Zhao, Sheng Li, Xuhong Chang, Yingbiao Sun
Cisplatin (CIS) is widely applied for its antihematological malignancies properties and as antisolid tumors drugs. However, it could cause testicular damage related with oxidative stress and testosterone synthesis disorder. Studies reported that grape seed procyanidins extract (GSPE) could improve CIS induced-testes lesion via scavenging free radicals in animals, although its mechanisms were unclear. Therefore, the purpose of the present study was to explore the antagonistic mechanisms of GSPE on CIS-induced testes lesion...
April 3, 2018: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/29606625/s-nitrosoglutathione-reductase-gsnor-deficiency-results-in-secondary-hypogonadism
#8
Thomas A Masterson, Himanshu Arora, Shathiyah Kulandavelu, Rona S Carroll, Ursula B Kaiser, Sakir H Gultekin, Joshua M Hare, Ranjith Ramasamy
BACKGROUND: Excess reactive oxygen species and reactive nitrogen species are implicated in male infertility and impaired spermatogenesis. AIM: To investigate the effect of excess reactive nitrogen species and nitrosative stress on testicular function and the hypothalamic-pituitary-gonadal axis using the S-nitrosoglutathione reductase-null (Gsnor-/- ) mouse model. METHODS: Testis size, pup number, and epididymal sperm concentration and motility of Gsnor-/- mice were compared with those of age-matched wild-type (WT) mice...
March 29, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29604466/pon1-promoter-polymorphisms-contribute-to-pcos-susceptibility-and-phenotypic-outcomes-in-indian-women
#9
Roshan Dadachanji, Nuzhat Shaikh, Anushree Patil, Nalini Shah, Srabani Mukherjee
Polycystic ovary syndrome is a common endocrinopathy characterized by anovulatory infertility, hyperandrogenism, insulin resistance and oxidative stress, which predisposes affected women to reproductive and cardiometabolic complications in later life. We have investigated the association of PON1 promoter polymorphisms with PCOS susceptibility, PON1 activity and its related traits in Indian women. The genotypic and allelic frequency distribution of only -907G/C polymorphism in PON1 promoter showed significant difference between non-hyperandrogenic control and PCOS women, and was significantly associated with reduced susceptibility to PCOS, considering the recessive model...
March 28, 2018: Gene
https://www.readbyqxmd.com/read/29599841/the-anti-fatigue-activities-of-tuber-melanosporum-in-a-mouse-model
#10
Xue Jiang, Qiubo Chu, Lanzhou Li, Luyao Qin, Jie Hao, Ling Kou, Feng Lin, Di Wang
Tuber melanosporum (TM) is an edible fungus that exhibits antioxidant and anti-tumor activity via its unique bioactive metabolites. The present study analyzed the anti-fatigue effects of TM using a BALB/c mouse model. The anti-fatigue properties of TM were evaluated by assessing the endurance of mice by performing forced swimming, rotary rod and running tests. Following 2 weeks TM treatment, hepatic and muscular ATP, and glycogen levels were increased in mice subjected to 30 min swimming, compared with controls...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29577206/stress-response-to-physical-exercise-in-rats-with-alimentary-obesity
#11
N A Pal'chikova, O I Kuzminova, V G Selyatitskaya
Stress response to physical exercise was studied in rats with alimentary obesity with and without caloric diet restriction. Daily excretion of corticosterone, progesterone, and testosterone, weights of internal organs, and serum levels of glucose, free fatty acids, triglycerides, corticosterone, and testosterone were estimated. Stress response to moderate exercise in rats with alimentary obesity was associated with predominance of anabolic influence of testosterone over the catabolic effects of corticosterone, which promoted the increase in the weight of reproductive organs...
March 26, 2018: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29559852/-bmi1-deficient-mice-exhibit-male-infertility
#12
Xiuliang Dai, Qian Zhang, Zhenzhen Yu, Weiwei Sun, Rong Wang, Dengshun Miao
Previous studies have demonstrated that the polycomb repressor Bmi1 is universally expressed in all types of testicular cells and might regulate the spermatogonia proliferation, however, it is unclear whether Bmi1 plays a critical role in maintaining normal male fertility in vivo. To answer this question, we first confirmed that Bmi1 is universally expressed in all types of testicular cells and found that the gene relative expression levels of Bmi1 in testis were the highest relative to other organs. Then we investigated the role of Bmi1 in maintaining normal male fertility using Bmi1 knockout male mouse model...
2018: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/29550552/expression-profiles-of-amhy-and-major-sex-related-genes-during-gonadal-sex-differentiation-and-their-relation-with-genotypic-and-temperature-dependent-sex-determination-in-pejerrey-odontesthes-bonariensis
#13
Yan Zhang, Ricardo S Hattori, Munti Sarida, Estefany C García, Carlos Augusto Strüssmann, Yoji Yamamoto
To shed light on the mechanisms of and interactions of GSD and TSD in pejerrey, we investigated how the transcriptional profiles of amhy and amha are affected by feminizing (17°C) and masculinizing (29°C) temperatures during the critical period of sex determination/differentiation and their relation with the expression profiles of AMH receptor type II (amhrII), gonadal aromatase (cyp19a1a), and 11 beta-hydroxysteroid dehydrogenase 2 (hsd11b2). Careful consideration of the results of this study and all information currently available for this species, including similar analyzes for an intermediate, mixed-sex promoting temperature (25°C), suggests a model for genotypic/temperature-dependent sex determination and gonadal sex differentiation that involves a) cyp19a1a-dependent, developmentally-programmed ovarian development as the default state that becomes self-sustaining in the absence of a potent and timely masculinizing stimulus, b) early, developmentally-programmed amhy expression and high temperature as masculinization signals that antagonize the putative female pathway by suppressing cyp19a1a expression, c) increasing stress response, cortisol, and the synthesis of the masculinizing androgen 11-keto-testosterone via hsd11b2 with increasing temperature that is important for masculinization in both genotypes but particularly so in XX individuals, and d) an endocrine network with positive/negative feedback mechanisms that ensure fidelity of the male/female pathway once started...
March 14, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29549542/the-gendered-family-process-model-an-integrative-framework-of-gender-in-the-family
#14
Joyce J Endendijk, Marleen G Groeneveld, Judi Mesman
This article reviews and integrates research on gender-related biological, cognitive, and social processes that take place in or between family members, resulting in a newly developed gendered family process (GFP) model. The GFP model serves as a guiding framework for research on gender in the family context, calling for the integration of biological, social, and cognitive factors. Biological factors in the model are prenatal, postnatal, and pubertal androgen levels of children and parents, and genetic effects on parent and child gendered behavior...
March 16, 2018: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/29547348/sex-specific-associations-between-telomere-dynamics-and-oxidative-status-in-adult-and-nestling-pied-flycatchers
#15
Jimena López-Arrabé, Pat Monaghan, Alejandro Cantarero, Winnie Boner, Lorenzo Pérez-Rodríguez, Juan Moreno
Oxidative stress can contribute to an acceleration of telomere erosion, leading to cellular senescence and aging. Increased investment in reproduction is known to accelerate senescence, generally resulting in reduced future reproductive potential and survival. To better understand the role played by oxidative status and telomere dynamics in the conflict between maintenance and reproduction, it is important to determine how these factors are related in parents and their offspring. We investigated the relationship between oxidative status and telomere measurements in pied flycatchers (Ficedula hypoleuca)...
May 2018: Physiological and Biochemical Zoology: PBZ
https://www.readbyqxmd.com/read/29545088/stress-sleep-and-sex-a-review-of-endocrinological-research-inoctodon-degus
#16
REVIEW
Carolyn M Bauer, Loreto A Correa, Luis A Ebensperger, L Michael Romero
The Common Degu (Octodon degus) is a small rodent endemic to central Chile. It has become an important model for comparative vertebrate endocrinology because of several uncommon life-history features - it is diurnal, shows a high degree of sociality, practices plural breeding with multiple females sharing natal burrows, practices communal parental care, and can easily be studied in the laboratory and the field. Many studies have exploited these features to make contributions to comparative endocrinology. This review summarizes contributions in four major areas...
March 12, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29544963/effects-of-chronic-testosterone-administration-on-the-degree-of-preference-for-a-high-fat-diet-and-body-weight-in-gonadal-intact-and-ovariectomized-female-rats
#17
Takeshi Iwasa, Toshiya Matsuzaki, Kiyohito Yano, Mayila Yiliyasi, Akira Kuwahara, Sumika Matsui, Minoru Irahara
Energy balance and reproductive functions are closely linked in some species. The sex hormones (estrogens and androgens) are involved in the regulation of appetite, metabolism, body weight (BW), and body composition in mammals. Previously, we showed that the effects of testosterone on BW, appetite, and fat weight were markedly affected by alterations to the gonadal hormonal milieu. In this study, we examined whether testosterone administration changes food preferences and whether these effects of testosterone depend on gonadal status in female rats...
March 12, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29543591/effects-of-tributyltin-on-placental-cytokine-production
#18
Yuko Arita, Michael Kirk, Neha Gupta, Ramkumar Menon, Darios Getahun, Morgan R Peltier
OBJECTIVE: Tributyltin (TBT) is a persistent pollutant but its effects on placental function are poorly understood as are its possible interactions with infection. We hypothesized that TBT alters the production of sex hormones and biomarkers for inflammation and neurodevelopment in an infection-dependent manner. METHODS: Placental explant cultures were treated with 0-5000 nM TBT in the presence and absence of Escherichia coli. A conditioned medium was harvested and concentrations of steroids (progesterone, P4; testosterone, T and estradiol, E2) as well as biomarkers of inflammation [interleukin (IL)-1β (IL-1β), tumor necrosis factor (TNF-α), IL-10, IL-6, soluble glycoprotein 130 (sgp-130) and heme oxygenase-1 (HO-1)], oxidative stress [8-iso-prostaglandin (8-IsoP)] and neurodevelopment [brain-derived neurotrophic factor (BDNF)] were quantified...
March 15, 2018: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/29527700/grape-seed-extract-attenuates-dexamethasone-induced-testicular-and-thyroid-dysfunction-in-male-albino-rats
#19
N A Hasona
This study scrutinised the ameliorative properties of grape seed extract (GSE) in dexamethasone (DEX)-induced testicular and thyroid dysfunction associated with oxidative stress in male albino rats. Thirty-two healthy adult male albino rats were divided into four groups of eight animals each: normal, DEX control, DEX + GSE (200 mg/kg body weight) group and DEX + GSE (400 mg/kg body weight) group. The body weight gain and testes weight were assessed. Plasma testosterone and thyroid profile were determined...
March 12, 2018: Andrologia
https://www.readbyqxmd.com/read/29526572/chronic-intermittent-hypoxia-induces-hormonal-and-male-sexual-behavioral-changes-hypoxia-as-an-advancer-of-aging
#20
E Nicole Wilson, Marc Anderson, Brina Snyder, Phong Duong, Jenny Trieu, Derek A Schreihofer, Rebecca L Cunningham
Sleep apnea is a common sleep disorder characterized by intermittent periods of low blood oxygen levels. The risk for sleep apnea increases with age and is more prevalent in men than women. A common comorbidity of sleep apnea includes male sexual dysfunction, but it is not clear if a causal relationship exists between sleep apnea and sexual dysfunction. Possible mechanisms that link these two disorders include oxidative stress and testosterone. Oxidative stress is elevated in clinical patients with sleep apnea and in rodents exposed to chronic intermittent hypoxia (CIH), an animal model for apnea-induced hypopnea...
March 8, 2018: Physiology & Behavior
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