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https://www.readbyqxmd.com/read/29224095/sex-differences-in-muscle-wasting
#1
Lindsey J Anderson, Haiming Liu, Jose M Garcia
With aging and other muscle wasting diseases, men and women undergo similar pathological changes in skeletal muscle: increased inflammation, enhanced oxidative stress, mitochondrial dysfunction, satellite cell senescence, elevated apoptosis and proteasome activity, and suppressed protein synthesis and myocyte regeneration. Decreased food intake and physical activity also indirectly contribute to muscle wasting. Sex hormones also play important roles in maintaining skeletal muscle homeostasis. Testosterone is a potent anabolic factor promoting muscle protein synthesis and muscular regeneration...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29222516/impact-of-self-esteem-and-sex-on-stress-reactions
#2
Lydia Kogler, Eva-Maria Seidel, Hannah Metzler, Hanna Thaler, Roland N Boubela, Jens C Pruessner, Ilse Kryspin-Exner, Ruben C Gur, Christian Windischberger, Ewald Moser, Ute Habel, Birgit Derntl
Positive self-evaluation is a major psychological resource modulating stress coping behavior. Sex differences have been reported in self-esteem as well as stress reactions, but so far their interactions have not been investigated. Therefore, we investigated sex-specific associations of self-esteem and stress reaction on behavioral, hormonal and neural levels. We applied a commonly used fMRI-stress task in 80 healthy participants. Men compared to women showed higher activation during stress in hippocampus, precuneus, superior temporal gyrus (STG) and insula...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29216724/inhibition-by-egb761-of-the-effect-of-cellphone-radiation-on-the-male-reproductive-system
#3
F Gevrek, D Aydin, S Ozsoy, H Aygun, C Bicer
OBJECTIVES: To determine the effects of Egb761 on testicular tissues and semen parameters in rats exposed to cellphone waves. BACKGROUND: EGb761 has antioxidant properties as a free-radical scavenger. Cellphone electromagnetic radiation (EMR) induces oxidative stress in cells. METHODS: Twenty-one Wistar albino male adult rats were divided into three groups (control, experimental, treatment), including seven rats in each. The experimental and treatment groups were exposed to cellphone EMR (0...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29214690/%C3%AE-lipoic-acid-inhibits-testicular-and-epididymal-oxidative-damage-and-improves-fertility-efficacy-in-arsenic-intoxicated-rats
#4
Papisetty Prathima, Ramanadhapuram Pavani, Sadepalli Sukeerthi, Sri Bhashyam Sainath
The present study evaluates the protective effect of α-lipoic acid (LA) against arsenic-induced testicular and epididymal oxidative damage in rats. Arsenic caused significant reduction in the reproductive organ weights, serum testosterone levels, testicular daily sperm count, epididymal sperm count, sperm motility, sperm viability, and sperm membrane integrity. Significant reduction in the activity levels of superoxide dismutase, catalase, and glutathione levels with a concomitant increase in the lipid peroxidation and protein carbonyl content in the testis and the cauda epididymis of arsenic-exposed rats...
December 7, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/29207507/zinc-ameliorate-oxidative-stress-and-hormonal-disturbance-induced-by-methomyl-abamectin-and-their-mixture-in-male-rats
#5
Sameeh A Mansour, Mostafa A Abbassy, Hassan A Shaldam
Exposure to mixtures of toxicants (e.g., pesticides) is common in real life and a subject of current concern. The present investigation was undertaken to assess some toxicological effects in male rats following exposure to methomyl (MET), abamectin (ABM), and their combination (MET+ABM), and to evaluate the ameliorative effect of zinc co-administration. Three groups of rats were designated for MET, ABM, and the mixture treatments. Three other groups were designated for zinc in conjunction with the pesticides...
December 3, 2017: Toxics
https://www.readbyqxmd.com/read/29200094/characteristics-of-a-national-level-female-weightlifter-peaking-for-competition-a-case-study
#6
Caleb D Bazyler, Satoshi Mizuguchi, Michael C Zourdos, Kimitake Sato, Ashley A Kavanaugh, Brad H DeWeese, Kevin F Breuel, Michael H Stone
This study investigated physiological and performance changes of a national level 69kg female weightlifter following three competition phases over a 28-week training period. The athlete first trained for a regional championship (weeks 1-12), followed by a local competition (weeks 13-23) and the national championship (weeks 24-28). Body mass, vastus lateralis cross-sectional area, and unloaded and loaded squat jump performance were assessed weekly during each 4-week competition phase. Serum biomarkers, and dynamic mid-thigh pulls were assessed prior to and after each competition phase...
December 1, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29198509/testosterone-deficiency-causes-endothelial-dysfunction-via-elevation-of-asymmetric-dimethylarginine-and-oxidative-stress-in-castrated-rats
#7
Tomoya Kataoka, Yuji Hotta, Yasuhiro Maeda, Kazunori Kimura
BACKGROUND: Testosterone is believed to mediate the penile erectile response by producing adequate nitric oxide; therefore, testosterone deficiency results in erectile dysfunction through decreased nitric oxide bioavailability. However, the mechanisms underlying endothelial dysfunction in testosterone deficiency remain unclear. AIM: To investigate the mechanism of endothelial dysfunction in a rat model of testosterone deficiency. METHODS: Rats were distributed into 3 groups: castrated (Cast), castrated and supplemented with testosterone (Cast + T), and sham (Sham)...
December 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29198215/dietary-l-arginine-supplementation-improves-semen-quality-and-libido-of-boars-under-high-ambient-temperature
#8
J Q Chen, Y S Li, Z J Li, H X Lu, P Q Zhu, C M Li
l-Arginine is a nutritionally essential amino acid for spermatogenesis and plays versatile roles in animal health and can be utilized as a potential agent to improve reproductive performance of boars under high ambient temperature. The present study aimed to determine whether dietary l-arginine could alleviate heat stress-induced infertility in boars. In all, 20 boars (PIC 1040; 248.59±3.84 kg BW and 407.65±6.40 days of age) were selected and randomly assigned to four groups (group 0.0%, basal diet; group 0...
December 4, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29197623/dual-effects-of-sulfasalazine-on-rat-sperm-characteristics-spermatogenesis-and-steroidogenesis-in-two-experimental-models
#9
Mohammad Mehdi Ommati, Reza Heidari, Akram Jamshidzadeh, Mohammad Javad Zamiri, Zilong Sun, Samira Sabouri, Jundong Wang, Fatemeh Ahmadi, Nafiseh Javanmard, Kazem Seifi, Saeed Mousapour, Babak Shirazi Yeganeh
There are reports of sulfasalazine (Salazosulfapyridine; SASP)-induced reproductive toxicity, but there it is not known whether the SASP molecule or its intestinal metabolites are responsible for this effect. Rats received SASP (150, 300, and 600mg/kg) for 60 consecutive days (in vivo). Additionally, epididymal sperm was isolated and incubated with SASP (10μM-1600μM) (in vitro). Markers of oxidative stress, mitochondrial function, and sperm functionality, along with testis histopathology as well as several steroidogenic genes and proteins, including steroidogenic acute regulatory (StAR) protein, cytochrome P450 side chain cleavage enzyme (P450scc; Cyp11a), 3β-hydroxysteroid dehydrogenase (3β-HSD), 17β-hydroxysteroid dehydrogenase (17β-HSD) were measured...
November 29, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/29197553/evidence-for-condition-mediated-trade-offs-between-the-hpa-and-hpg-axes-in-the-wild-zebra-finch
#10
Ondi L Crino, Sophia M Jensen, Katherine L Buchanan, Simon C Griffith
Opportunistic breeding is a strategy used to maximize reproductive success in unpredictable environments. Birds that breed opportunistically are thought to maintain partial activation of the reproductive axis in order to rapidly initiate breeding when environmental conditions become suitable. The physiological mechanisms that modulate reproduction in seasonally breeding birds have been well explored. In contrast, the physiological mechanisms that allow opportunistic breeding birds to maintain a continued state of reproductive readiness has not been well established...
November 29, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29195019/is-immunosuppression-induced-by-neonatal-thymectomy-compatible-with-poor-reproductive-performance-in-adult-male-rats
#11
M M Ommati, N Tanideh, B Rezakhaniha, J Wang, S Sabouri, M Vahedi, B Dormanesh, O Koohi Hosseinabadi, F Rahmanifar, S Moosapour, A Akhlaghi, R Heidari, M J Zamiri
With increasing knowledge that the immune system has a major impact on reproductive ‎health, the potential for cells arising in organs such as the thymus to alleviate oxidative stress ‎has been revealed. This study addresses the impact of neonatal thymectomy on male ‎reproductive function in pubertal and adult animals. Neonatal Sprague Dawley rats were allotted to four treatments consisting of fully thymectomized, partially thymectomized, intact, and sham-operated rats. Half of the rats in each treatment were sacrificed at 40 and the other half at 80 days of age...
December 1, 2017: Andrology
https://www.readbyqxmd.com/read/29194818/rapid-non-genomic-modulation-by-neurosteroids-of-dendritic-spines-in-the-hippocampus-androgen-estrogen-and-corticosteroid
#12
REVIEW
Gen Murakami, Yasushi Hojo, Asami Kato, Yoshimasa Komatsuzaki, Shigeo Horie, Mika Soma, Jonghyuk Kim, Suguru Kawato
Memories are stored in synapses which consist of axon terminals and dendritic spines. Dendritic spines are postsynaptic structures of synapses and essential for synaptic plasticity and cognition. Therefore, extensive investigations about functions and structures of spines have been performed. Sex steroids and stress steroids have been shown to modulate hippocampal synapses. Although rapid modulatory action of sex steroids on synapses has been studied in hippocampal neurons over several decades, its essential molecular mechanisms have not been fully understood...
December 1, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29184794/should-we-expand-the-indications-for-varicocele-treatment
#13
REVIEW
Ioannis Vakalopoulos, Spyridon Kampantais, Stefania Lymperi, Nikolaos Grivas, Anastasios Ioannidis, Ioannis Mykoniatis, Vassilios Nikolaou, Georgios Dimitriadis
Current guidelines suggest that treatment of varicocele should be considered in patients with clinically palpable disease and abnormal semen parameters. However, the clinicians are often challenged with the decision whether to treat varicocele in patients with testicular pain or low testosterone levels. Moreover, varicocele is highly associated with DNA fragmentation due to the oxidative stress and it has been demonstrated that surgical repair of varicocele ameliorates oxidative stress markers and consequently the sperm DNA integrity...
October 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29181751/effect-of-gasoline-fumes-on-reproductive-function-in-male-albino-rats
#14
Folarin O Owagboriaye, Gabriel A Dedeke, Joseph S Ashidi, Adeyinka A Aladesida, Wasiu E Olooto
The increase in the frequency of exposure to gasoline fumes and the growing incidence of infertility among humans has been a major concern and subject of discussion over the years in Nigeria. We therefore present the reproductive effect of gasoline fumes on inhalation exposure in 40 male albino rats. The rats were randomized into five experimental treatments (T) with eight rats per treatment. T1 (control) was exposed to distilled water while T2, T3, T4, and T5 were exposed to gasoline fumes in exposure chambers for 1, 3, 5, and 9 h daily respectively for 12 weeks...
November 27, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29177247/protective-effects-of-curcumin-co-treatment-in-rats-with-establishing-chronic-variable-stress-on-testis-and-reproductive-hormones
#15
Masoomeh Mohamadpour, Ali Noorafshan, Saied Karbalay-Doust, Tahereh Talaei-Khozani, Elham Aliabadi
Background: Protracted and repeated exposure to chronic variable stress (CVS) may lead to reproductive dysfunction. It is a basic cause of male infertility. Curcumin (CUR) is an active fraction of turmeric that used in traditional Chinese medicine. CUR represents various pharmacological activities. Objective: The purpose of this study was to determining the effects of CUR on testis and testosterone, follicle stimulating hormone (FSH) and luteinizing hormone (LH) in rats with establishing chronic variable stress...
July 2017: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29174957/alternatives-to-testosterone-therapy-a-review
#16
REVIEW
Eric M Lo, Katherine M Rodriguez, Alexander W Pastuszak, Mohit Khera
INTRODUCTION: Although testosterone therapy (TTh) is an effective treatment for hypogonadism, recent concerns regarding its safety have been raised. In 2015, the US Food and Drug Administration issued a warning about potential cardiovascular risks resulting from TTh. Fertility preservation is another reason to search for viable alternative therapies to conventional TTh, and in this review we evaluate the literature examining these alternatives. AIMS: To review the role and limitations of non-testosterone treatments for hypogonadism...
November 23, 2017: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/29169010/oxidative-stress-burden-inhibits-spermatogenesis-in-adult-male-rats-testosterone-protective-effect
#17
Samy Makary, Mohamed Abdo, Ereny Fekry
In this study, we aimed to investigate the protective effects of androgens, using letrozole (LET; an aromatase inhibitor), grape seed extract (GSE; a naturally occurring aromatase inhibitor and antioxidant), and testosterone propionate (Tp), against methotrexate (MTX)-induced testicular toxicity in adult male rats. MTX has been shown to induce oxidative stress and exhibit antiproliferative effects in the testes. Adult male rats received oral saline gavage (control group with no treatment), the potential protective agents (LET, GSE, or Tp) alone, MTX alone, or a combination of one of the potential protective agents and MTX...
November 23, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/29164652/cerium-oxide-nanoparticle-elicits-oxidative-stress-endocrine-imbalance-and-lowers-sperm-characteristics-in-testes-of-balb-c-mice
#18
O A Adebayo, O Akinloye, O A Adaramoye
The toxicity of metallic nanoparticles is a growing concern due to its application in industries and homes. We investigated the toxicity of cerium oxide nanoparticles (CeO2 NPs) on reproductive system in male balb/c mice. Twenty mice were divided into four groups of five animals each and treated thus: normal saline (control), 100, 200 and 300 μg/kg CeO2 NPs (i.p.,) thrice in a week for five consecutive weeks. Results showed that CeO2 NPs significantly reduced the levels of haemoglobin, PCV and RBC count relative to controls...
November 21, 2017: Andrologia
https://www.readbyqxmd.com/read/29155118/patterns-of-neuroendocrine-coupling-in-9-year-old-children-effects-of-sex-body-mass-index-and-life-stress
#19
Sarah R Black, Matthew D Lerner, Elizabeth A Shirtcliff, Daniel N Klein
Previous investigations have explored stress and pubertal hormones in parallel; it has been a recent development, however, to explore the relationships between different hormones during puberty, and how this hormonal cross-talk may be influenced by the environment. The current study investigated neuroendocrine coupling, or the extent to which hormones are correlated within the individual, and also investigated early life stressors that may influence coupling. Participants were 405 adrenarcheal children (mean Tanner stage=1...
November 16, 2017: Biological Psychology
https://www.readbyqxmd.com/read/29127912/pesticides-contaminated-dust-exposure-risk-diagnosis-and-exposure-markers-in-occupational-and-residential-settings-of-lahore-pakistan
#20
Sidra Waheed, Crispin Halsall, Andrew J Sweetman, Kevin C Jones, Riffat Naseem Malik
There are few studies documenting the dust loaded with pesticides as a potential non-dietary exposure source for occupational worker and populations living near agricultural farms and pesticides formulation plants. In present study we have evaluated the pesticide concentration in dust from potential sites and relevant health risk from dust ingestion. Furthermore, the effect of currently used pesticides was investigated on blood and urine parameters of subjects: farmer, factory worker, urban resident and rural resident and controlled subjects with presumably different levels of exposure...
November 7, 2017: Environmental Toxicology and Pharmacology
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