keyword
https://read.qxmd.com/read/38534366/steroidogenesis-upregulation-through-mitochondria-associated-endoplasmic-reticulum-membranes-and-mitochondrial-dynamics-in-rat-testes-the-role-of-d-aspartate
#1
JOURNAL ARTICLE
Debora Latino, Massimo Venditti, Sara Falvo, Giulia Grillo, Alessandra Santillo, Imed Messaoudi, Mariem Ben Rhouma, Sergio Minucci, Gabriella Chieffi Baccari, Maria Maddalena Di Fiore
Mitochondria-Associated Endoplasmic Reticulum Membranes (MAMs) mediate the communication between the Endoplasmic Reticulum (ER) and the mitochondria, playing a fundamental role in steroidogenesis. This study aimed to understand how D-aspartate (D-Asp), a well-known stimulator of testosterone biosynthesis and spermatogenesis, affects the mechanism of steroidogenesis in rat testes. Our results suggested that D-Asp exerts this function through MAMs, affecting lipid trafficking, calcium signaling, ER stress, and mitochondrial dynamics...
March 16, 2024: Cells
https://read.qxmd.com/read/38533024/bezafibrate-alleviates-diabetes-induced-spermatogenesis-dysfunction-by-inhibiting-inflammation-and-oxidative-stress
#2
JOURNAL ARTICLE
Yang Mu, Ling-Bo Luo, Shu-Juan Wu, Yue Gao, Xiao-Lin Qin, Jing Zhao, Qian Liu, Jing Yang
The metabolic disorders caused by diabetes can lead to various complications, including male spermatogenesis dysfunction. Exploring effective therapeutics that attenuate diabetes mellitus (DM)-induced male subfertility is of great importance. Pharmaceuticals targeting PPARα activation such as bezafibrate have been regarded as an important strategy for patients with diabetes. In this study, we use streptozocin (STZ) injection to establish a type 1 DM mice model and use bezafibrate to treat DM mice and evaluate the effects of bezafibrate on the spermatogenic function of the DM male mice...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38528700/piperine-mitigates-oxidative-stress-inflammation-and-apoptosis-in-the-testicular-damage-induced-by-cyclophosphamide-in-mice
#3
JOURNAL ARTICLE
Fatemeh Fani, Seyed Jalal Hosseinimehr, Mehryar Zargari, Mansoureh Mirzaei, Abbasali Karimpour Malekshah, Fereshteh Talebpour Amiri
Although cyclophosphamide (CP) has been approved as an anticancer drug, its toxic effect on most organs, especially the testis, has been established. Piperine (PIP) is an alkaloid that has antioxidant, antiapoptotic, and anti-inflammatory activities. This study was investigated the protective effects of PIP on CP-induced testicular toxicity in the mice. In this experimental study, 48 adult male BALB/c mice (30-35 g) were divided into six groups (n = 8), receiving normal saline (C), 5 mg/kg of PIP (PIP5), 10 mg/kg of PIP (PIP10), 200 mg/kg of CP, 200 mg/kg of CP + PIP5, and 200 mg/kg of CP + PIP10...
April 2024: Journal of Biochemical and Molecular Toxicology
https://read.qxmd.com/read/38528285/molecular-regulatory-mechanism-of-nano-se-against-copper-induced-spermatogenesis-disorder
#4
JOURNAL ARTICLE
Yujuan Ouyang, Yanbing Lou, Yanqiu Zhu, Yihan Wang, Song Zhu, Lin Jing, Tingting Yang, Hengmin Cui, Huidan Deng, Zhicai Zuo, Jing Fang, Hongrui Guo
Selenium nanoparticle (Nano-Se) is a new type of selenium supplement, which can improve the deficiency of traditional selenium supplements and maintain its physiological activity. Due to industrial pollution and irrational use in agriculture, Cu overexposure often occurs in animals and humans. In this study, Nano-Se alleviated CuSO4 -induced testicular Cu accumulation, serum testosterone level decrease, testicular structural damage, and decrease in sperm quality. Meanwhile, Nano-Se reduced the ROS content in mice testis and enhanced the activities of T-AOC, GSH, SOD, and CAT compared with CuSO4 group...
March 26, 2024: Biological Trace Element Research
https://read.qxmd.com/read/38525521/beneficial-effects-of-oral-antioxidant-supplementation-on-semen-quality-parameters-reproductive-hormones-and-sperm-dna-integrity-in-men-with-idiopathic-oligoasthenoteratozoospermia
#5
JOURNAL ARTICLE
Chaymae Rochdi, Meriem Ouadrhiri, Larbi Allai, Ibtissam Bellajdel, Samira Mamri, Hafsa Taheri, Hanane Saadi, Ahmed Mimouni, Mohammed Choukri
OBJECTIVE: Recently, oral antioxidants in combined forms have been used to treat men with idiopathic infertility. This study aimed to evaluate the effects of treatment with vitamin C, vitamin E, selenium, zinc, arginine, L-carnitine, and coenzyme Q10 on sperm quality parameters, DNA integrity, reproductive hormones, and pregnancy rates in men with infertility and idiopathic oligoasthenoteratozoospermia (OAT). METHODS: A prospective study was conducted on 420 men with infertility and idiopathic OAT who took an oral supplement of antioxidant SP-Power tablets twice daily for 6 months...
March 25, 2024: Clinical and Experimental Reproductive Medicine
https://read.qxmd.com/read/38522820/chlorpyrifos-impairs-sperm-parameters-and-number-of-sertoli-and-leydig-cells-in-rats-after-exposure-during-the-peripubertal-period
#6
JOURNAL ARTICLE
Ivana Regina da Costa, Débora Hipólito Quadreli, Lucas Marcelo Meira da Silva, Fábio Goulart de Andrade, Glaura Scantamburlo Alves Fernandes
Chlorpyrifos is an organophosphate insecticide used to control pests in crops. Thus, humans are constantly exposed through ingestion of contaminated food or water, inhalation of contaminated air, and through the skin. The juvenile and peripubertal periods comprise a window of development of the reproductive system, sensitive to toxic agents. Considering the scarcity of data on exposure to the insecticide during these periods, the aim of this study was to evaluate the effects of chlorpyrifos on the testis during the juvenile and peripubertal periods...
March 22, 2024: Toxicology
https://read.qxmd.com/read/38522604/melatonin-alleviates-glyphosate-induced-testosterone-synthesis-inhibition-via-targeting-mitochondrial-function-in-roosters
#7
JOURNAL ARTICLE
Yu-Long Ren, Qing Liang, Cai-Yu Lian, Wei Zhang, Lin Wang
Glyphosate (GLY) is a widely used herbicide that has been revealed to inhibit testosterone synthesis in humans and animals. Melatonin (MET) is an endogenous hormone that has been demonstrated to promote mammalian testosterone synthesis via protecting mitochondrial function. However, it remains unclear whether MET targets mitochondria to alleviate GLY-inhibited testosterone synthesis in avian. In this study, an avian model using 7-day-old rooster upon chronic exposure to GLY with the treatment of MET was designed to clarify this issue...
March 22, 2024: Environmental Pollution
https://read.qxmd.com/read/38520788/syringin-alleviates-bisphenol-a-induced-spermatogenic-defects-and-testicular-injury-by-suppressing-oxidative-stress-and-inflammation-in-male-zebrafish
#8
JOURNAL ARTICLE
Ye Zhao, Xu Luo, Jinyuan Hu, Mogellah John Panga, Clara Appiah, Zhanxiang Du, Lin Zhu, Vladimir Retyunskiy, Xing Gao, Bo Ma, Qi Zhang
Syringin (SRG) is a bioactive principle possessing extensive activities including scavenging of free radicals, inhibition of apoptosis, and anti-inflammatory properties. However, its effects on spermatogenic defects and testicular injury as well as the underlying mechanisms are still unclear. This study aims to investigate the protective effect of SRG on testis damage in zebrafish and explore its potential molecular events. Zebrafish testicular injury was induced by exposure to bisphenol A (BPA) (3000 μg/L) for two weeks...
March 22, 2024: International Immunopharmacology
https://read.qxmd.com/read/38518815/a-novel-approach-of-using-maca-root-as-a-radioprotector-in-a-rat-testicular-damage-model-focusing-on-grp78-chop-caspase-3-pathway
#9
JOURNAL ARTICLE
Mai H Mekkawy, Fatma Y Abdou, Maha M Ali, Amira Abd-ElRaouf
PURPOSE: Despite the effectiveness of ionizing radiation in treating cancer, it can damage healthy tissues in the vicinity. Due to the high radio-sensitivity of testicular tissues, radiation therapy may affect spermatogenesis, which may result in infertility. Hence, in this study testicular damage model is constructed to investigate the mitigation effect of Maca root powder and its potential radioprotective activity through both oxidative and endoplasmic reticulum (ER) stresses, besides the apoptotic pathway...
March 20, 2024: Archives of Biochemistry and Biophysics
https://read.qxmd.com/read/38513920/molecular-insights-into-the-antioxidative-and-anti-inflammatory-effects-of-p-coumaric-acid-against-bisphenol-a-induced-testicular-injury-in-vivo-and-in-silico-studies
#10
JOURNAL ARTICLE
Samet Tekin, Emin Sengul, Serkan Yildirim, Emrah Hicazi Aksu, İsmail Bolat, Burak Çınar, Azizeh Shadidizaji, Fikret Çelebi, Mohamad Warda
This study investigated the protective effects of p-coumaric acid (PCA) against bisphenol A (BPA)-induced testicular toxicity in male rats. The rats were divided into control, BPA, BPA+PCA50, BPA+PCA100, and PCA100 groups. Following a 14-day treatment period, various analyses were conducted on epididymal sperm quality and testicular tissues. PCA exhibited dose-dependent cytoprotective, antioxidant, and anti-inflammatory effects, ameliorating the decline in sperm quality induced by BPA. The treatment elevated antioxidant enzyme activities (SOD, GPx, CAT) and restored redox homeostasis by increasing cellular glutathione (GSH) and reducing malondialdehyde (MDA) levels...
March 19, 2024: Reproductive Toxicology
https://read.qxmd.com/read/38503191/androgen-regulation-of-behavioral-stress-responses-and-the-hypothalamic-pituitary-adrenal-axis
#11
JOURNAL ARTICLE
Damian G Zuloaga, Jennifer J Lafrican, Kristen L Zuloaga
Testosterone is a powerful steroid hormone that can impact the brain and behavior in various ways, including regulating behavioral and neuroendocrine (hypothalamic-pituitary-adrenal (HPA) axis) stress responses. Early in life androgens can act to alter development of brain regions associated with stress regulation, which ultimately impacts the display of stress responses later in life. Adult circulating androgens can also influence the expression of distinct genes and proteins that regulate stress responses...
March 18, 2024: Hormones and Behavior
https://read.qxmd.com/read/38497875/effect-of-melatonin-on-reproductive-function-in-propylthiouracil-induced-hypothyroidism-in-adult-male-rats
#12
JOURNAL ARTICLE
W Ezzat, W K Abdelbasset, R S Hussien, A R Azab, A Sulieman, S Yousry
OBJECTIVE: Thyroid hormones are essential for regulating metabolism, reproduction, and growth. Hypothyroidism is connected with lower sperm count and motility, leading to male infertility. Oxidative stress is likely to be linked to this interaction. Melatonin, being known as an oxidative scavenger, may offer a feasible treatment method for reproductive dysfunction accompanying hypothyroidism in adult male rats. The purpose of this investigation was to determine the mechanism by which melatonin treatment affected spermatogenic and steroidogenic function in an experimental model-induced hypothyroidism in adult male rats...
March 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38494020/metabolic-disruptions-and-impaired-reproductive-fitness-in-wild-caught-freshwater-turtles-emydura-macquarii-macquarii-exposed-to-elevated-per-and-polyfluoroalkyl-substances-pfas
#13
JOURNAL ARTICLE
David J Beale, Thao V Nguyen, Utpal Bose, Rohan Shah, Joost Laurus Dinant Nelis, Sally Stockwell, James A Broadbent, Sandra Nilsson, Rahul Rane, Leon Court, Damian C Lettoof, Gunjan Pandey, Thomas K Walsh, Stephanie Shaw, Josh Llinas, Duncan Limpus, Colin Limpus, Christoph Braun, Brenda Baddiley, Suzanne Vardy
Per- and poly-fluoroalkyl substances (PFAS) pose a threat to organisms and ecosystems due to their persistent nature. Ecotoxicology endpoints used in regulatory guidelines may not reflect multiple, low-level but persistent stressors. This study examines the biological effects of PFAS on Eastern short-necked turtles in Queensland, Australia. In this study, blood samples were collected and analysed for PFAS, hormone levels, and functional omics endpoints. High levels of PFAS were found in turtles at the impacted site, with PFOS being the dominant constituent...
March 15, 2024: Science of the Total Environment
https://read.qxmd.com/read/38484789/genotoxic-and-cytotoxic-effects-of-aflatoxin-on-the-reproductive-system-focus-on-cell-cycle-dynamics-and-apoptosis-in-testicular-tissue
#14
REVIEW
Cyrus Jalili, Rahele Ranjbar Shamsi, Bita Amiri, Seyran Kakebaraie, Faramarz Jalili, Touraj Zamir Nasta
Aflatoxins (AFs) are inevitable environmental contaminants that are detrimental to human and animal health. AFs interfere with metabolic processes, metabolizing into different hydroxylated derivatives in the liver, as well as mechanistically induce ROS accumulation, S-phase arrest, DNA damage, and cell apoptosis. Chronic consumption of aflatoxin-contaminated foods can adversely affect the male reproductive system, cause testicular damage, prevent testosterone synthesis, decline sperm quality, and cause infertility...
March 12, 2024: Toxicology
https://read.qxmd.com/read/38483938/the-beneficial-effect-of-allium-cepa-bulb-extract-on-reproduction-of-rats-a-two-generation-study-on-fecundity-and-sex-hormones
#15
JOURNAL ARTICLE
Sadia Suri, Saira Saeed Khan, Sadaf Naeem, Zeb Un Nisa, Nausheen Alam, Saba Majeed, Suresh Kumar, Rafeeq Alam Khan
Allium Cepa Linn. (Onions) has extensively been used in traditional medicine, is one of the important Allium species regularly used in our daily diet, and has been the source of robust phenolic compounds. The current study is intended to evaluate the fecundity-enhancing effect of A. Cepa on the reproductive performance of two successive generations of rats; F0 and F1. A. Cepa extract was initially tested for in vitro antioxidant assay via DPPH and ROS, followed by in vivo toxicity testing. In the fecundity assessment, eighteen pairs of male and female rats (n = 36, 1:1, F0 generation) were divided into three groups and dosed with 75mg/kg and 150 mg/kg daily of A...
2024: PloS One
https://read.qxmd.com/read/38483023/effects-of-chronic-mild-stress-induced-from-peripuberty-on-sexual-behavior-in-male-rats-with-or-without-escitalopram-treatment
#16
JOURNAL ARTICLE
Leonardo Wensing Fischer, Marina Nunes, Talita Biude Mendes, Joana Noguères Simas, Maria Martha Bernardi, Samara Urban de Oliva, Sandra Maria Miraglia
BACKGROUND: After the Coronavirus Disease pandemic, depression became more present, including in adolescents. Escitalopram, a selective serotonin reuptake inhibitor, was approved in 2009 for treatment of the major depressive disorder, both in children and adolescents. The undesirable effects of antidepressants on sexual dysfunction are usually underestimated. AIMS: To investigate the effects of chronic mild stress, induced from peripuberty up to adulthood, on male sexual behavior parameters, with or without the escitalopram treatment, using rats as experimental model in a translational study...
March 14, 2024: Andrology
https://read.qxmd.com/read/38479314/polystyrene-microplastics-impair-the-functions-of-cultured-mouse-leydig-tm3-and-sertoli-tm4-cells-by-inducing-mitochondrial-endoplasmic-reticulum-damage
#17
JOURNAL ARTICLE
Giulia Grillo, Sara Falvo, Debora Latino, Gabriella Chieffi Baccari, Massimo Venditti, Maria Maddalena Di Fiore, Sergio Minucci, Alessandra Santillo
Many laboratory studies demonstrated that the exposure to microplastics causes testosterone deficiency and spermatogenic impairment in mammals; however, the mechanism underlying this process remains still unclear. In this study, we investigated the effects of polystyrene microplastics (PS-MP) on the proliferation and functionality of cultured Leydig (TM3) and Sertoli (TM4) cells, focusing on the mitochondrial compartment and its association with the endoplasmic reticulum (ER). The in vitro exposure to PS-MP caused a substantial reduction in cellular viability in TM3 and TM4 cells...
March 12, 2024: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/38472840/protective-effect-of-black-rice-cyanidin-3-glucoside-on-testicular-damage-in-stz-induced-type-1-diabetic-rats
#18
JOURNAL ARTICLE
Hongxing Zheng, Yingjun Hu, Jia Zhou, Baolong Zhou, Shanshan Qi
Diabetic testicular damage is quite a common and significant complication in diabetic men, which could result in infertility. The natural fertility rate of type 1 diabetes men is only 50% because of testicular damage. This research first aimed to explore the intervention effect of C3G on testicular tissue damage induced by diabetes. Here, a streptozotocin-induced type 1 diabetic rat model was established, and then C3G was administered. After 8 weeks of C3G supplementation, the symptoms of diabetes (e.g., high blood glucose, lower body weight, polydipsia, polyphagia) were relieved, and at the same time that sperm motility and viability increased, sperm abnormality decreased in C3G-treated diabetic rats...
February 27, 2024: Foods (Basel, Switzerland)
https://read.qxmd.com/read/38472623/associations-between-serum-testosterone-levels-and-overactive-bladder-in-women-a-cross-sectional-research-of-nhanes-2011-to-2016
#19
JOURNAL ARTICLE
Wenshuang Li, Junlong Huang, Jialiang Chen, Chi Zhang, Ruixiang Luo, Bolong Liu, Xiangfu Zhou
PURPOSE: Androgen receptors are expressed in the pelvic floor and lower urinary tract. However, the association between serum testosterone and overactive bladder (OAB) in women remains unclear. This study aimed to investigate their association in a nationally representative population. METHODS: In this cross-sectional study, we collected data on female participants older than 20 years with serum total testosterone measurements and OAB questionnaires from the 2011-2016 National Health and Nutrition Examination Survey (NHANES)...
March 12, 2024: International Urology and Nephrology
https://read.qxmd.com/read/38471257/gonads-under-stress-a-systematic-review-and-meta-analysis-on-the-effects-of-acute-psychosocial-stress-on-gonadal-steroids-secretion-in-humans
#20
REVIEW
Gregor Domes, Katrin Linnig, Bernadette von Dawans
Animal research has shown that the hypothalamus-pituitary-gonadal (HPG) axis is inhibited by (chronic and/or severe) stress, which can lead to impaired fertility and reproductive functioning, presumably caused by the inhibition of gonadal steroid secretion and in interactions with glucocorticoids. However, what has not been clarified is how acute psychosocial stress modulates gonadal steroid secretion in humans. Here we summarize the experimental research on the acute effects of stress on the secretion of gonadal steroids in humans...
February 28, 2024: Psychoneuroendocrinology
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