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stress and testosterone

Muhammad Arslan Kamal Hashmi, Beate I Escher, Martin Krauss, Ivana Teodorovic, Werner Brack
The release of a multitude of pollutants from untreated municipal wastewater (UMWW) to surface waters may have adverse effects on aquatic wildlife including endocrine disruption. For effect-directed analysis (EDA), a Danube river water sample downstream of emission of UMWW in Novi Sad, Serbia was extracted on-site and after processing in the lab was subjected to reporter gene assays which revealed pronounced estrogenic (ERα), androgenic (AR) and oxidative stress response (OSR). The sample was fractionated with reversed-phase high performance liquid chromatography (RP-HPLC) collecting thirty fractions at two-minute intervals...
May 15, 2018: Science of the Total Environment
Jr-Di Yang, Shing-Hwa Liu, Mei-Hsiu Liao, Ruei-Ming Chen, Pei-Yu Liu, Tzuu-Huei Ueng
The major objective of the present study was to determine the ability of a triazole fungicide tebuconazole to induce cytochrome P450-dependent monooxygenases, oxidative stress, and endocrine-disrupting activity using male rats treated with tebuconazole at 10, 25, and 50 mg/kg p.o. once daily for 28 days. In liver, tebuconazole dose-dependently increased microsomal contents of cytochrome P450 and cytochrome b5 and the activities of NADPH-cytochrome P450 reductase, 7-ethoxyresorufin O-deethylase, methoxyresorufin O-demethylase, pentoxyresorufin O-dealkylase, 7-ethoxycoumarin O-deethylase, aniline hydroxylase, and erythromycin N-demethylase...
June 19, 2018: Environmental Toxicology
Mojtaba Ameli, Mohaddeseh Sadat Hashemi, Maryam Moghimian, Majid Shokoohi
OBJECTIVE: This study used a rat model to investigate the protective effect of tadalafil and verapamil on testicular function and oxidative stress after torsion/detorsion. METHODS AND MATERIALS: Animals were randomly divided into five groups: G1, Sham group; G2, testicular torsion followed by detorsion (TD); G3, testicular torsion/detorsion received 0/4 mg/kg of tadalafil (TDT); G4, testicular torsion/detorsion received 0/1 mg/kg of verapamil (TDV); and G5, testicular torsion/detorsion received 0/1 mg/kg of verapamil and 0/4 mg/kg of tadalafil (TDTV)...
June 19, 2018: Andrologia
Amy Tanner, Shannon Day
Given the limited research into the physiological and psychological demands of elite synchronised swimming, the aim of this study was to examine 10 elite female synchronised swimmers and analyse the relationship between training load, stress, illness episodes, and salivary biomarkers during a period of training and competition. Saliva samples were collected before (BASE), during an intensified training camp (CAMP), during an international competition period (COMP), and post competition recovery (REC) for analysis of cortisol, testosterone, and secretory immunoglobulin A (SIgA)...
September 1, 2017: Sports
Mayank Choubey, Ashutosh Ranjan, Puran S Bora, Fátima Baltazar, Amitabh Krishna
Obesity is a major health problem that is linked to decreased sperm count. It is hypothesized that an obesity-associated reduction in adiponectin secretion may be responsible for impairment of spermatogenesis. Therefore, the aim of the study was to evaluate the direct role of adiponectin in spermatogenesis and steroid synthesis in adult mice. This study showed that adiponectin receptors (AdipoR1 and AdipoR2) were localized in Leydig cells and seminiferous tubules in the testis of adult mice. The result of the in vitro study showed the direct action of adiponectin on spermatogenesis by stimulating cell proliferation (PCNA) and survival (Bcl2) and by suppressing cell apoptosis...
June 14, 2018: General and Comparative Endocrinology
Regina H Mossotti, Eli A Baskir, Corinne P Kozlowski, Ashley D Franklin, George A Feldhamer, Cheryl S Asa
Understanding the factors used by female cheetahs (Acinonyx jubatus) to make mate choice decisions could benefit zoo breeding programs, which currently assign mates based primarily on genetic distance. Because transporting animals between institutions is costly and can be stressful, females are often limited in the number of males available for mating. One solution would be to determine if an easily transported substance could be used to gauge interest by a female to a potential mate. Here, we investigate female interest in urine samples from males of different genetic distances...
June 13, 2018: Zoo Biology
Meredith C Miles, Maren N Vitousek, Jerry F Husak, Michele A Johnson, Lynn B Martin, Conor C Taff, Cedric Zimmer, Matthew B Lovern, Matthew J Fuxjager
Circulating steroid hormone levels exhibit high variation both within and between individuals, leading some to hypothesize that these phenotypes are more variable than other morphological, physiological, and behavioral traits. This should have profound implications for the evolution of steroid signaling systems, but few studies have examined how endocrine variation compares to that of other traits or differs among populations. Here we provide such an analysis by first exploring how variation in three measures of corticosterone (CORT)- baseline, stress-induced, and post-dexamethasone injection- compares to key traits characterizing morphology (wing length, mass), physiology (reactive oxygen metabolite concentration [d-ROMs] and antioxidant capacity), and behavior (provisioning rate) in two populations of tree swallow (Tachycineta bicolor)...
June 12, 2018: Integrative and Comparative Biology
Jian Zhao, Shi Ren, Chunyu Liu, Li Huo, Zheng Liu, Lingling Zhai
Objective: This study evaluated the effects of di-(2-ethylhexyl) phthalate (DEHP) and obesity on male reproductive organ function in male mice and the potential mechanism of male secondary hypogonadism (SH) in such mice. Methods: 140 mice were assigned to six groups for 12 weeks: normal, DEHP, DIO, DIO + DEHP low, DIO + DEHP middle, and DIO + DEHP high. The effects of DEHP and obesity upon the reproductive organs were determined by measuring sperm count and motility, relative testis and epididymis weight, hormone level, and pathological changes...
2018: Oxidative Medicine and Cellular Longevity
Rosita A Condorelli, Sandro La Vignera, Laura M Mongioì, Angela Alamo, Aldo E Calogero
Although the prevalence of sub-infertility in diabetic patients in childbearing age is known, the mechanisms by which diabetes mellitus (DM) causes male infertility are not completely explained. This detrimental effect is achieved with a variety of mechanisms that include pre-testicular, testicular, and post-testicular pathogenetic moments and can be different in type 1 diabetes mellitus (DM1) and type 2 diabetes mellitus (DM2) patients because of type of diabetes, duration of disease, and glycemic metabolic compensation...
2018: Frontiers in Endocrinology
Nosrat Bahrami, Saeed Mehrzadi, Mehdi Goudarzi, Esrafil Mansouri, Iman Fatemi
Di (2-ethylhexyl) phthalate (DEHP) is one of the environmental pollutants that causes testicular damage. Lycopene (LYCO), the main active carotenoid in red fruits and vegetables, has well-known antiinflammatory and antioxidant activities. The present study aimed to investigate the effects of LYCO on DEHP-induced testicular injury in male mice. DEHP (2 g/kg, p.o.) was given for two weeks to mice. LYCO was given at 4 mg/kg, p.o., for two weeks, starting the same day of DEHP insult. Serum testosterone, luteinizing hormone and follicle stimulating hormone and testicular total antioxidant status, malondialdehyde, nitric oxide, glutathione, superoxide dismutase, glutathione peroxidase, catalase, tumor necrosis factor-α, interleukin-1β were measured...
June 7, 2018: Life Sciences
Mathieu Giraudeau, Ann-Kathrin Ziegler, Kevin J Mcgraw, Monika Okuliarová, Michal Zeman, Barbara Tschirren
Mothers can influence prenatal conditions by varying the amount of nutrients, hormones or antioxidants they provide to their developing young. Some of these substances even affect the transfer of these compounds in the next generation, but it is less clear how different maternally transmitted compounds interact with each other to shape reproductive resource allocation in their offspring. Here, we found that female Japanese quails ( Coturnix japonica ) that were exposed to high carotenoid levels during embryonic development transferred lower concentrations of yolk antioxidants to their own eggs later in life...
June 2018: Biology Letters
Joe Herbert
Both testosterone and cortisol have major actions on financial decision-making closely related to their primary biological functions, reproductive success and response to stress, respectively. Financial risk-taking represents a particular example of strategic decisions made in the context of choice under conditions of uncertainty. Such decisions have multiple components, and this article considers how much we know of how either hormone affects risk-appetite, reward value, information processing and estimation of the costs and benefits of potential success or failure, both personal and social...
2018: Frontiers in Behavioral Neuroscience
Saeed Mehrzadi, Nosrat Bahrami, Mehrnaz Mehrabani, Manijeh Motevalian, Esrafil Mansouri, Mehdi Goudarzi
Chronic exposure to arsenic, an inducer of oxidative stress, is one of the major causes of male infertility. Therefore, the present study investigated the protective role of Ellagic acid (EA), as a natural antioxidant, against testicular toxicity evoked by arsenic. Thirty-five male Wistar rats were divided into 5 treatment groups. Group 1 served as control, group 2 were orally exposed to sodium arsenite (SA, 10 mg/kg; 21 days), groups 3 and 4 were initially exposed to SA for 7 days and then were treated with both EA (10 and 30 mg/kg) and SA up to 21 days, and group 5 was treated with EA for 14 days...
July 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Isaac A Adedara, Olatunde Owoeye, Babajide O Ajayi, Ifeoluwa O Awogbindin, Joao B T Rocha, Ebenezer O Farombi
Exposure to pesticide chlorpyrifos (CPF) has been implicated in reproductive deficits in both humans and animals. Diphenyl diselenide (DPDS) is an organoselenium compound widely reported to elicit potent pharmacological activities in several chemically-induced toxicity and disease models. However, there is paucity of scientific information on the influence of DPDS on CPF-induced reproductive dysfunction. The present study investigated the influence of DPDS on CPF-induced functional changes along the hypothalamic-pituitary- testicular axis in rats...
May 31, 2018: Biochemical and Biophysical Research Communications
Mehri Jamilian, Mansooreh Samimi, Naghmeh Mirhosseini, Faraneh Afshar Ebrahimi, Esmat Aghadavod, Rezavan Talaee, Sadegh Jafarnejad, Shahrzad Hashemi Dizaji, Zatollah Asemi
OBJECTIVE: The aim of this study was to evaluate the effect of the co-administration of vitamin D and omega-3 fatty acid on clinical, metabolic and genetic parameters in women with polycystic ovary syndrome (PCOS). METHODS: This randomized, double-blinded, placebo-controlled clinical trial was conducted on 60 subjects, aged 18-40 years old with PCOS. Subjects were randomly allocated to take either 50,000 IU vitamin D every 2 weeks plus 2000 mg/day omega-3 fatty acid from fish oil (n = 30) or placebo (n = 30) for 12 weeks...
May 26, 2018: Journal of Affective Disorders
Samar R Saleh, Rana Attia, Doaa A Ghareeb
This study was aimed at evaluating the efficacy of berberine-rich fraction (BF) as a protective and/or a therapeutic agent against inflammation and oxidative stress during male infertility. Sexually mature Sprague-Dawley male rats were divided into five groups treated with either corn oil, BF (100 mg/kg BW, orally, daily for 30 days), gossypol acetate (5 mg/kg BW, i.p.) eight times for 16 days, BF alone for 14 days then coadministered with gossypol acetate for the next 16 days (protected group), or gossypol acetate for 16 days then treated with BF for 30 days (treated group)...
2018: Oxidative Medicine and Cellular Longevity
Jacqueline Rano, Cecilia Fridén, Frida Eek
BACKGROUND: While physical activity has been shown to affect psychological as well as physiological stress responses, less research has explored the effects of acute stress on athletic performance. The current study hence aimed to investigate the effect of an Acute Psychological Stress (APS) provocation on performance and plasma lactate concentration during a following 200m swim race among male elite swimmers. Furthermore, associations between physiological stress responses (salivary cortisol and testosterone), and outcome measures (speed and lactate) were explored...
May 29, 2018: Journal of Sports Medicine and Physical Fitness
Jessica C Raisanen, Sara B Chadwick, Nicholas Michalak, Sari M van Anders
Sexual desire and testosterone are widely assumed to be directly and positively linked to each other despite the lack of supporting empirical evidence. The literature that does exist is mixed, which may result from a conflation of solitary and dyadic desire, and the exclusion of contextual variables, like stress, known to be relevant. Here, we use the Steroid/Peptide Theory of Social Bonds as a framework for examining how testosterone, solitary and partnered desire, and stress are linked over time. To do so, we collected saliva samples (for testosterone and cortisol) and measured desire as well as other variables via questionnaires over nine monthly sessions in 78 women and 79 men...
May 29, 2018: Archives of Sexual Behavior
Prabin Gyawali, Sean A Martin, Leonie K Heilbronn, Andrew D Vincent, Anne W Taylor, Robert J T Adams, Peter D O'Loughlin, Gary A Wittert
AIMS: Contrasting findings exist regarding the association between circulating sex hormone-binding globulin (SHBG) and testosterone levels and type 2 diabetes (T2D) in men. We examined prospective associations of SHBG and sex steroids with incident T2D in a cohort of community-dwelling men. METHODS: Participants were from a cohort study of community-dwelling (n = 2563), middle-aged to elderly men (35-80 years) from Adelaide, Australia (the Men Androgen Inflammation Lifestyle Environment and Stress (MAILES) study)...
May 29, 2018: Acta Diabetologica
Isaac A Adedara, Olubunmi Omole, Edozie S Okpara, Opeyemi B Fasina, Modupe F Ayeni, Olamide M Ajayi, Esther O Busari, Ebenezer O Farombi
Protocatechuic acid (PCA; 3, 4-dihydroxybenzoic acid) is a phenolic compound widely found in many edible fruits, vegetables, grape wine and plant-derived beverages. The present study investigated the impact of PCA on the hypothalamus-pituitary-testicular axis of rats orally treated with PCA during the period of prepubertal development to adulthood. Protocatechuic acid was administered to prepubertal male rats at doses of 0, 5, 10, 50 and 100 mg/kg body for 45 consecutive days. The results revealed no treatment-related changes in the body weight gain and organo-somatic indices of the hypothalamus, testes, epididymis, prostate gland and seminal vesicle in rats administered with PCA when compared with control...
May 26, 2018: Chemico-biological Interactions
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