keyword
MENU ▼
Read by QxMD icon Read
search

early hepatocellular carcinoma

keyword
https://www.readbyqxmd.com/read/28820518/living-with-hepatocellular-carcinoma-near-the-end-of-life-family-caregivers-perspectives
#1
Lissi Hansen, Susan J Rosenkranz, Kathleen Wherity, Anna Sasaki
PURPOSE/OBJECTIVES: To explore family caregivers' perspectives of caring for patients with terminal hepatocellular carcinoma (HCC) as patients approached the end of life.
. RESEARCH APPROACH: Longitudinal, qualitative descriptive design.
. SETTING: Oregon Health and Science University in Portland and Veterans Affairs Portland Health Care System in Oregon.
. PARTICIPANTS: 13 family caregivers with a mean age of 56 years (range = 22-68 years)...
September 1, 2017: Oncology Nursing Forum
https://www.readbyqxmd.com/read/28815645/lenalidomide-as-second-line-therapy-for-advanced-hepatocellular-carcinoma-exploration-of-biomarkers-for-treatment-efficacy
#2
Y-Y Shao, B-B Chen, D-L Ou, Z-Z Lin, C-H Hsu, M-J Wang, A-L Cheng, C Hsu
BACKGROUND: Lenalidomide has immunomodulatory and anti-angiogenic effects and showed moderate anti-tumour efficacy in patients with. advanced hepatocellular carcinoma (HCC) AIM: To explore potential biomarkers of lenalidomide efficacy as second-line therapy for HCC. METHODS: Eligible patients were diagnosed with advanced HCC, documented progression on sorafenib, and Child-Pugh class A liver function. Patients received 25 mg/day lenalidomide orally on days 1-21 every 4 weeks...
August 17, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28809739/wait-time-for-curative-intent-radio-frequency-ablation-is-associated-with-increased-mortality-in-patients-with-early-stage-hepatocellular-carcinoma
#3
Giuseppe Montalto, Maurizio Soresi, Anna Licata, Lydia Giannitrapani
No abstract text is available yet for this article.
August 8, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28809734/wait-time-for-curative-intent-radio-frequency-ablation-is-associated-with-increased-mortality-in-patients-with-early-stage-hepatocellular-carcinoma
#4
Mayur Brahmania, Osman Ahmed, Melissa Kelley, David Wong, Matthew Kowgier, Korosh Khalili, Rob Beecroft, Eberhard L Renner, Hemant Shah, Jordan Feld, Harry L A Janssen, Morris Sherman
INTRODUCTION: Radiofrequency ablation (RFA) is a recommended curative intent treatment option for patients with early stage hepatocellular carcinoma (HCC). We investigated if wait times for RFA were associated with residual tumor, tumor recurrence, need for liver transplantation, or death. MATERIAL AND METHODS: We conducted a retrospective study of patients diagnosed with HCC between January 2010 and December 2013 presenting to University Health Network (UHN) in Toronto, Canada...
August 8, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28807570/albumin-bilirubin-grade-predicts-the-outcomes-of-liver-resection-versus-radiofrequency-ablation-for-very-early-early-stage-of-hepatocellular-carcinoma
#5
Charing Ching-Ning Chong, Anthony Wing-Hung Chan, John Wong, Cheuk-Man Chu, Stephen Lam Chan, Kit-Fai Lee, Simon Chun-Ho Yu, Ka-Fai To, Philip Johnson, Paul Bo-San Lai
BACKGROUND AND PURPOSE: Whether liver resection or ablation should be the first-line treatment for very early/early hepatocellular carcinoma (HCC) in patients who are candidates for both remains controversial. The aim of this study was to determine if the newly-developed Albumin-Bilirubin (ALBI) grade might help in treatment selections and to evaluate the survival of patients treated with liver resection and radiofrequency ablation (RFA). METHODS: Patients with BCLC stage 0/A HCC who were treated with curative liver resection and RFA from 2003 to 2013 were included...
August 11, 2017: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
https://www.readbyqxmd.com/read/28801777/an-internally-validated-new-clinical-and-inflammation-based-prognostic-score-for-patients-with-advanced-hepatocellular-carcinoma-treated-with-sorafenib
#6
R Diaz-Beveridge, G Bruixola, D Lorente, J Caballero, E Rodrigo, Á Segura, D Akhoundova, A Giménez, J Aparicio
BACKGROUND: Sorafenib is a standard treatment for patients (pts) with advanced hepatocellular carcinoma (aHCC), although the clinical benefit is heterogeneous between different pts groups. Among novel prognostic factors, a low baseline neutrophil-to-lymphocyte ratio (bNLR) and early-onset diarrhoea have been linked with a better prognosis. PURPOSE: To identify prognostic factors in pts with aHCC treated with 1st-line sorafenib and to develop a new prognostic score to guide management...
August 11, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28801286/-value-of-detection-of-serum-glypican-3-level-in-diagnosis-and-therapeutic-effect-evaluation-of-primary-hepatocellular-carcinoma
#7
Yuan-Yuan Wang, Chen-Jie Zhou, Jing Li, Ling Zhou, Ming-Song Li, Bing Xiao
OBJECTIVE: To explore the clinical value of detecting serum glypican-3 in the diagnosis and therapeutic effect evaluation of primary hepatocellular carcinoma (PHC). METHODS: Using sandwich ELISA, we detected serum glypican-3 levels in 60 patients with PHC, 60 with metastatic liver cancer, 50 with liver cirrhosis, 50 with chronic viral hepatitis, 20 with hepatic cyst, 20 with fatty liver, 20 with hepatic hemangioma and 20 with drug-induced hepatitis as well as in 40 healthy subjects (control)...
August 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28796071/overexpression-of-microrna-let-7-correlates-with-disease-progression-and-poor-prognosis-in-hepatocellular-carcinoma
#8
Wenxia Shi, Zili Zhang, Bin Yang, Hua Guo, Li Jing, Tong Liu, Ying Luo, Hui Liu, Yayue Li, Yingtang Gao
The aim of the study was to explore the clinical significance of let-7 expression in hepatocellular carcinoma (HCC).A PCR array was conducted to screen for let-7 expression in early-stage HCC. Next, the deregulation of let-7 was confirmed by quantitative real-time RT-PCR (qRT-PCR) in another set of liver tissues, including normal control (NC), chronic hepatitis (CH), liver cirrhosis (LC), HCC, and adjacent nontumor (NT) tissues. In addition, as the potential target mRNA of let-7, alpha 2(I) collagen (COL1A2) mRNA was also quantified in the above liver tissues...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28795996/initial-alpha-fetoprotein-response-predicts-prognosis-in-hepatitis-b-related-solitary-hcc-patients-after-radiofrequency-ablation
#9
Su Jong Yu, Jee Hye Kwon, Won Kim, Jung-Hwan Yoon, Jeong Min Lee, Jae Young Lee, Eun Ju Cho, Jeong-Hoon Lee, Hwi Young Kim, Yong Jin Jung, Yoon Jun Kim
BACKGROUND: Radiofrequency ablation (RFA) is effective for early-stage hepatocellular carcinoma but recurrence is problem. GOALS: To identify prognostic factors including alpha-fetoprotein (AFP) for overall survival and intrahepatic recurrence after RFA. PATIENTS AND METHODS: Not only naïve but also previously treated patients with solitary hepatitis B virus-related hepatocellular carcinoma <5 cm were prospectively enrolled and a ≥50% decrease from baseline to 1 month after RFA was defined as an initial AFP response...
August 8, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28795155/detection-of-urine-dna-markers-for-monitoring-recurrent-hepatocellular-carcinoma
#10
Hie-Won Hann, Surbhi Jain, Grace Park, Jamin D Steffen, Wei Song, Ying-Hsiu Su
AIM: This study aimed to explore the potential of detecting hepatocellular carcinoma (HCC)-associated DNA markers, TP53 249T mutations and aberrant methylation of RASSF1A and GSTP1 genes, for monitoring HCC recurrence. HCC remains a leading cause of death worldwide, with one of the fastest growing incidence rates in the US. While treatment options are available and new ones emerging, there remains a poor prognosis of this disease mostly due to its late diagnosis and high recurrence rate...
2017: Hepatoma Research
https://www.readbyqxmd.com/read/28791798/cost-effectiveness-analysis-of-potentially-curative-and-combination-treatments-for-hepatocellular-carcinoma-with-person-level-data-in-a-canadian-setting
#11
Hla-Hla Thein, Wanrudee Isaranuwatchai, Yao Qiao, Kenny Wong, Gonzalo Sapisochin, Kelvin K W Chan, Eric M Yoshida, Craig C Earle
Patients with early-stage hepatocellular carcinoma (HCC) are potential candidates for curative treatments such as radiofrequency ablation (RFA), surgical resection (SR), or liver transplantation (LT), which have demonstrated a significant survival benefit. We aimed to estimate the cost-effectiveness of curative and combination treatment strategies among patients diagnosed with HCC during 2002-2010. This study used Ontario Cancer Registry-linked administrative data to estimate effectiveness and costs (2013 USD) of the treatment strategies from the healthcare payer's perspective...
August 8, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28791711/is-early-recurrence-of-hepatocellular-carcinoma-in-hcv-cirrhotic-patients-affected-by-treatment-with-direct-acting-antivirals-a-prospective-multicentre-study
#12
G Cabibbo, S Petta, V Calvaruso, I Cacciola, M R Cannavò, S Madonia, M Distefano, L Larocca, T Prestileo, F Tinè, G Bertino, L Giannitrapani, F Benanti, A Licata, I Scalisi, G Mazzola, F Cartabellotta, N Alessi, M Barbàra, M Russello, G Scifo, G Squadrito, G Raimondo, A Craxì, V Di Marco, C Cammà
BACKGROUND: Data on HCV-related hepatocellular carcinoma (HCC) early recurrence in patients whose HCC was previously cured, and subsequently treated by direct-acting antivirals (DAAs), are equivocal. AIM: To assess the risk of HCC early recurrence after DAAs exposure in a large prospective cohort of HCV-cirrhotic patients with previous successfully treated HCC, also looking for risk factors for cancer early recurrence. METHODS: We enrolled 143 consecutive patients with complete response after curative treatment of HCC, subsequently treated with DAAs and monitored by the web-based RESIST-HCV database...
August 9, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28774415/new-treatments-to-reach-functional-cure-virological-approaches
#13
REVIEW
David Durantel
Current therapies of chronic hepatitis B (CHB) remain limited to pegylated-interferon-alpha (pegIFN-α) or any of the five approved nucleos(t)ide analogues (NA). If viral suppression can be achieved in the majority of patients with the high-barrier-to-resistance new-generation of NA, i.e. entecavir and tenofovir, HBsAg loss is achieved by PEG-IFN-α and/or NA in only 10% of patients, after a 5-year follow-up. Attempts to improve the response by administering two different NA or a combination of NA and PEG-IFN-α have not provided a dramatic increase in the rate of "functional cure"...
June 2017: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/28771246/diagnosis-and-treatment-of-tyrosinemia-type-i-a-us-and-canadian-consensus-group-review-and-recommendations
#14
REVIEW
Jeffrey M Chinsky, Rani Singh, Can Ficicioglu, Clara D M van Karnebeek, Markus Grompe, Grant Mitchell, Susan E Waisbren, Muge Gucsavas-Calikoglu, Melissa P Wasserstein, Katie Coakley, C Ronald Scott
Tyrosinemia type I (hepatorenal tyrosinemia, HT-1) is an autosomal recessive condition resulting in hepatic failure with comorbidities involving the renal and neurologic systems and long term risks for hepatocellular carcinoma. An effective medical treatment with 2-[2-nitro-4-trifluoromethylbenzoyl]-1,3-cyclohexanedione (NTBC) exists but requires early identification of affected children for optimal long-term results. Newborn screening (NBS) utilizing blood succinylacetone as the NBS marker is superior to observing tyrosine levels as a way of identifying neonates with HT-1...
August 3, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/28770990/multiplex-immunochips-for-high-accuracy-detection-of-afp-l3-based-on-surface-enhanced-raman-scattering-implications-for-early-liver-cancer-diagnosis
#15
Hao Ma, Xiaoying Sun, Lei Chen, Weina Cheng, Xiao Xia Han, Bing Zhao, Chengyan He
α-Fetoprotein (AFP) is an important tumor biomarker. In particular, the overexpression of AFP-L3 is associated with hepatocellular carcinoma (HCC). Accordingly, several hospitals have begun to employ the ratio of AFP-L3 to the total AFP level (AFP-L3%) as new diagnostic evidence for HCC owing to its high diagnostic accuracy. However, current methods of detection for AFP and AFP-L3 are time-consuming, require multiple samples, and lack in sensitivity and specificity. Herein, we present a novel concept for the early diagnosis of HCC based on the combination of Raman frequency shift and intensity change, and developed surface-enhanced Raman scattering (SERS)-based immunochips via AFP-L3%...
August 10, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28769581/clinical-utility-of-nitisinone-for-the-treatment-of-hereditary-tyrosinemia-type-1-ht-1
#16
REVIEW
Anibh Martin Das
Medical therapy for hereditary hepatorenal tyrosinemia (hereditary tyrosinemia type 1, HT-1) with nitisinone was discovered incidentally, and is a by-product of agrochemistry. It blocks the catabolic pathway of tyrosine, thereby leading to a reduction in the accumulation of toxic metabolites in HT-1. It has to be combined with a low-protein diet supplemented with amino acid mixtures devoid of tyrosine and phenylalanine. This treatment option has completely changed the clinical course of patients suffering from HT-1 who used to die in the first few months to years of life from liver failure, renal dysfunction, and/or hepatocellular carcinoma (HCC)...
2017: Application of Clinical Genetics
https://www.readbyqxmd.com/read/28764978/vitamin-d-and-k-signaling-pathways-in-hepatocellular-carcinoma
#17
REVIEW
Manal L Louka, Ahmed M Fawzy, Abdelrahman M Naiem, Mustafa F Elseknedy, Ahmed E Abdelhalim, Mohamed A Abdelghany
Hepatocellular carcinoma (HCC) is a primary liver malignancy, and is now the six most common in between malignancies. Early diagnosis of HCC with prompt treatment increases the opportunity of patients to survive. With the advances in understanding the molecular biology of HCC, new therapeutic strategies to treat HCC have emerged. There is a growing consensus that vitamins are important for the control of various cancers. Biochemical evidence clearly indicates that HCC cells are responsive to the inhibitory effect of vitamin D, vitamin D analogues and vitamin K...
July 29, 2017: Gene
https://www.readbyqxmd.com/read/28763838/-modern-knowledge-and-development-trend-of-intrahepatic-cholangiocellular-carcinoma
#18
Q Wang, H B Zhou, H P Hu
Although intrahepatic cholangiocellular carcinoma (ICC) has a relatively low incidence rate, it ranks the second in the most common primary malignant liver tumors, with hepatocellular carcinoma ranking the first. Meanwhile, its incidence and mortality rates tend to increase significantly in the past decades. On the one hand, due to a lack of characteristic clinical symptoms, specific tumor markers, and imaging findings, early diagnosis of ICC is extremely difficult; on the other hand, ICC has highly malignant biological behaviors and early extrahepatic metastasis, so patients often experience early recurrence even if surgical resection is performed, which leads to the poor prognosis of such patients...
May 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/28763836/-early-imaging-diagnosis-of-primary-liver-cancer
#19
L L Long, P Peng, Z K Huang
Hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver, and in the process of HCC development, early identification and timely treatment can significantly improve patient survival rate. Imaging techniques play an important role in the monitoring of chronic liver diseases, evolution of cirrhotic nodules, and early diagnosis of HCC. Multi-phase or dynamic contrast-enhanced computed tomography and magnetic resonance imaging (MRI) reflect the changes in blood supply during the evolution of liver cirrhotic nodules...
May 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/28763835/-molecular-markers-for-the-monitoring-of-malignant-transformation-of-hepatocytes-and-early-diagnosis-of-liver-cancer
#20
Y Yang, M Yao, M Fang, W J Zheng, Z Z Dong, D F Yao
The monitoring of malignant transformation of hepatocytes or early diagnosis of primary hepatocellular carcinoma (PHC) remains a challenge in the medical world. Routine examinations including serum alpha-fetoprotein level and ultrasound examination have a limited value in the diagnosis of small hepatocellular carcinoma; however, the effective treatment of PHC depends on its early diagnosis. In recent years, molecular markers including important signaling molecules in PHC-related pathways, carcinoembryonic proteins, and non-coding RNA help with the monitoring of malignant transformation of hepatocytes or early diagnosis of liver cancer...
May 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
keyword
keyword
14664
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"