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https://www.readbyqxmd.com/read/28750481/aqueous-shunts-for-glaucoma
#1
REVIEW
Victoria L Tseng, Anne L Coleman, Melinda Y Chang, Joseph Caprioli
BACKGROUND: Aqueous shunts are employed to control intraocular pressure (IOP) for people with primary or secondary glaucomas who fail or are not candidates for standard surgery. OBJECTIVES: To assess the effectiveness and safety of aqueous shunts for reducing IOP in glaucoma compared with standard surgery, another type of aqueous shunt, or modification to the aqueous shunt procedure. SEARCH METHODS: We searched CENTRAL (which contains the Cochrane Eyes and Vision Trials Register) (2016, Issue 8), MEDLINE Ovid (1946 to August 2016), Embase...
July 28, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28750477/anti-pcsk9-antibodies-for-hypercholesterolaemia-overview-of-clinical-data-and-implications-for-primary-care
#2
REVIEW
Olivier S Descamps, Uwe Fraass, Ricardo Dent, Winfried März, Ioanna Gouni-Berthold
OBJECTIVES: To put data from our recent systematic review of phase 3 studies of anti-proprotein convertase subtilisin/kexin type 9 (PCSK9) antibodies into the context of clinical practice. METHODS: Data from studies previously identified by a systematic review of phase 3 studies of alirocumab and evolocumab and additional references from non-systematic literature searches were used. We evaluated the hypothetical cardiovascular (CV) benefit in cases of typical patients in whom anti-PCSK9 antibodies may be recommended, using preliminary major CV event (CVE) rates from long-term clinical trials of anti-PCSK9 antibodies and from extrapolations derived from correlation between low-density lipoprotein cholesterol (LDL-C) reduction and CV benefit with other lipid-lowering therapies (LLTs)...
July 27, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28750436/-retinal-vascular-occlusion-modern-therapeutic-approaches
#3
Moritz Pettenkofer, Nicolas Feltgen, Nikolaus Feucht, Chris P Lohmann, Mathias M Maier
Retinal artery occlusion (RAO) should be evaluated as an emergency and can be seen as an ocular analogue to the cerebral apoplex. Both have the same arteriosclerotic risk factors, which are also responsible for cardiac, circulatory and cerebrovascular diseases. That is why an intensive interdisciplinary clarification is necessary to recognize possible comorbidities in time and, if necessary, to treat them. The current therapeutic possibilities of an acute RAO are very limited in their efficiency regarding visual improvement...
July 27, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28750428/experiences-in-sensor-augmented-pump-therapy-in-families-with-two-children-with-type-1-diabetes-a-qualitative-study
#4
Franziska Bomba, Esther Müller-Godeffroy, Simone von Sengbusch
Background Caring for a child with type 1 diabetes is a tremendous challenge for a family. The aim of the study was to explore the experiences of transition to sensor-augmented pump therapy (SAP) in families with 2 affected children and the internal and external conditions which potentially impede or facilitate the adjustment process. Methods 5 families (9 parents, 8 children and adolescents) who used the SAP technology for 6 months were interviewed to describe their experiences. The interviews were analysed using thematic content analysis...
July 27, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28750422/-atorvastatin-therapy-under-clinical-practice-conditions-which-ldl-c-levels-are-achieved-in-patients-at-very-high-cardiovascular-risk
#5
Ulrich Laufs, Christina Jannowitz, David Pittrow
Current information on the utilisation of atorvastatin under clinical practice conditions is limited. The cross sectional study DISCOVER documented in the period from June until December 2014 dose and effects on lipids in ambulatory patients at very high cardiovascular risk, who were treated with atorvastatin monotherapy (original drug or generics). Of 2625 patients (mean age 66.1 ± 10.8 years, 62.1 % males), 47.0 % had coronary heart disease (CHD), 25.1 % type 2 diabetes mellitus (DM), and 27.9 % CHD plus concomitant DM...
July 27, 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28750360/brain-and-skull-base-mri-findings-in-patients-with-ollier-maffucci-disease-a-series-of-12-patient-cases
#6
Emmanuel Mandonnet, Philippe Anract, Elisabeth Martin, Thomas Roujeau, Giannantonio Spena, Valérie Cormier-Daire, Hugues Duffau, Genneviève Baujat
OBJECTIVES: To estimate the prevalence rate of silent cranial and intracranial lesions in a series of Ollier-Maffucci patients. PATIENTS AND METHODS: Cerebral MRI was routinely performed in Ollier-Maffucci patients followed-up in our tertiary centers. Patients with previous history of skull base or intracranial tumors were excluded from the study. Clinical and radiological datas were retrospectively collected. The occurrence rate and nature of abnormal cerebral MRIs were determined...
July 18, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28750264/the-perpetrators-of-medical-child-abuse-munchausen-syndrome-by-proxy-a-systematic-review-of-796-cases
#7
REVIEW
Gregory Yates, Christopher Bass
INTRODUCTION: Little is known about the perpetrators of medical child abuse (MCA) which is often described as "Munchausen's syndrome by proxy" or "factitious disorder imposed on another". The demographic and clinical characteristics of these abusers have yet to be described in a sufficiently large sample. We aimed to address this issue through a systematic review of case reports and series in the professional literature. METHOD: A systematic search for case reports and series published since 1965 was undertaken using MEDLINE, Web of Science and EMBASE...
July 24, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28750229/improving-assessment-accuracy-for-lake-biological-condition-by-classifying-lakes-with-diatom-typology-varying-metrics-and-modeling-multimetric-indices
#8
Bo Liu, R Jan Stevenson
Site grouping by regions or typologies, site-specific modeling and varying metrics among site groups are four approaches that account for natural variation, which can be a major source of error in ecological assessments. Using a data set from the 2007 National Lakes Assessment project of the USEPA, we compared performances of multimetric indices (MMI) of biological condition that were developed: (1) with different lake grouping methods, ecoregions or diatom typologies; (2) by varying or not varying metrics among site groups; and (3) with different statistical techniques for modeling diatom metric values expected for minimally disturbed condition for each lake...
July 24, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28750182/subacute-sclerosing-panencephalitis-should-be-eliminated-by-measles-vaccination
#9
Wei-Liang Liu, Zhi-Xu He, Fang Li, Dian He, Rong Ai
1 patient with SSPE at 4 y. He had had measles and measles encephalitis at 7.5 months. In China, the first and the second measles immunizations are recommended at 8 months and at 18-24 months, respectively. We recommend above immunizations should be given separately at 6 months and at 12 months.
July 27, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28750178/modifying-an-evidence-based-lifestyle-programme-for-individuals-with-traumatic-brain-injury
#10
Simon Driver, Megan Reynolds, Kaye Kramer
OBJECTIVE: Individuals with traumatic brain injury (TBI) are at a risk of obesity-related chronic diseases; yet, no evidence-based strategies exist to support weight management in this population. The purpose of this study was to use participatory action research to modify the Diabetes Prevention Program Group Lifestyle Balance (DPP-GLB) programme for overweight/obese people with TBI. The DPP-GLB programme provides education and self-management skills for individuals to reach their lifestyle goals through healthy eating and physical activity...
July 27, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28750141/hepatocellular-carcinoma-in-patients-with-chronic-hepatitis-c-and-cirrhosis-in-denmark-a-nationwide-cohort-study
#11
Sofie Hallager, Steen Ladelund, Mette S Kjaer, Lone G Madsen, Erika Belard, Alex Lund Laursen, Jan Gerstoft, Birgit T Røge, Karin E Grønbaek, Henrik B Krarup, Peer B Christensen, Nina Weis
Cirrhosis in patients with chronic hepatitis C increases the risk of hepatocellular carcinoma (HCC) and surveillance with ultrasound (US) and alpha-fetoprotein (AFP) is recommended. This study aimed to estimate changes in the HCC incidence rate (IR) over time, HCC stage and prognosis, and AFP and US performed in patients with hepatitis C and cirrhosis. Eligible patients were identified in the Danish Database for Hepatitis B and C and data from national health registries and patient charts were obtained. Tumor stage was based on Barcelona-Clinic Liver Cancer stage, TNM classification and size and number of lesions combined into stage 0 - 3...
July 27, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/28750052/determinants-of-enrollment-of-informal-sector-workers-in-cooperative-based-health-scheme-in-bangladesh
#12
Abdur Razzaque Sarker, Marufa Sultana, Rashidul Alam Mahumud, Sayem Ahmed, Ziaul Islam, Alec Morton, Jahangir A M Khan
BACKGROUND: Providing access to affordable health care for the informal sector remains a considerable challenge for low income countries striving to make progress towards universal health coverage. The objective of the study is to identify the factors shaping the decision to enroll in a cooperative based health scheme for informal workers in Bangladesh and also help to identify the features of informal workers without health schemes and their likelihood of being insured. METHODS: Data were derived from a cross-sectional in-house survey within the catchment area of a cooperative based health scheme in Bangladesh during April-June 2014, covering a total of 784 households (458 members and 326 non-members)...
2017: PloS One
https://www.readbyqxmd.com/read/28750032/spatial-characteristics-and-the-epidemiology-of-human-infections-with-avian-influenza-a-h7n9-virus-in-five-waves-from-2013-to-2017-in-zhejiang-province-china
#13
Haocheng Wu, XinYi Wang, Ming Xue, Melanie Xue, Chen Wu, Qinbao Lu, Zheyuan Ding, Xiaoping Xv, Junfen Lin
BACKGROUND: The five-wave epidemic of H7N9 in China emerged in the second half of 2016. This study aimed to compare the epidemiological characteristics among the five waves, estimating the possible infected cases and inferring the extent of the possible epidemic in the areas that have not reported cases before. METHODS: The data for the H7N9 cases from Zhejiang Province between 2013 and 2017 was obtained from the China Information Network System of Disease Prevention and Control...
2017: PloS One
https://www.readbyqxmd.com/read/28749996/misinformation-lingers-in-memory-failure-of-three-pro-vaccination-strategies
#14
Sara Pluviano, Caroline Watt, Sergio Della Sala
People's inability to update their memories in light of corrective information may have important public health consequences, as in the case of vaccination choice. In the present study, we compare three potentially effective strategies in vaccine promotion: one contrasting myths vs. facts, one employing fact and icon boxes, and one showing images of non-vaccinated sick children. Beliefs in the autism/vaccines link and in vaccines side effects, along with intention to vaccinate a future child, were evaluated both immediately after the correction intervention and after a 7-day delay to reveal possible backfire effects...
2017: PloS One
https://www.readbyqxmd.com/read/28749980/coverage-and-factors-associated-with-influenza-vaccination-among-kindergarten-children-2-7-years-old-in-a-low-income-city-of-north-western-china-2014-2016
#15
Lili Xu, Ying Qin, Juan Yang, Wei Han, Youju Lei, Huaxiang Feng, Xiaoyun Zhu, Yanming Li, Hongjie Yu, Luzhao Feng, Yan Shi
Influenza vaccination has been shown to be the most effective preventive measure to reduce influenza virus infection and its related morbidity and mortality. Young children aged 6-59 months are recommended as one of the priority groups for seasonal influenza vaccination in China. Our study was conducted to evaluate the level of influenza vaccination coverage during 2014-15 and 2015-16 influenza seasons among kindergarten children aged 2-7 years in Xining, a low-income city of north-western China, and to explore potential factors for noncompliance associated with influenza vaccination...
2017: PloS One
https://www.readbyqxmd.com/read/28749979/attitudes-and-decision-making-about-early-infant-versus-early-adolescent-male-circumcision-demand-side-insights-for-sustainable-hiv-prevention-strategies-in-zambia-and-zimbabwe
#16
Sema K Sgaier, Sunny Sharma, Maria Eletskaya, Ram Prasad, Owen Mugurungi, Bushimbwa Tambatamba, Getrude Ncube, Sinokuthemba Xaba, Alice Nanga, Sehlulekile Gumede-Moyo, Steve Kretschmer
As countries approach their scale-up targets for the voluntary medical male circumcision program for HIV prevention, they are strategizing and planning for the sustainability phase to follow. Global guidance recommends circumcising adolescent (below 14 years) and/or early infant boys (aged 0-60 days), and countries need to consider several factors before prioritizing a cohort for their sustainability phase. We provide community and healthcare provider-side insights on attitudes and decision-making process as a key input for this strategic decision in Zambia and Zimbabwe...
2017: PloS One
https://www.readbyqxmd.com/read/28749976/information-filtering-based-on-corrected-redundancy-eliminating-mass-diffusion
#17
Xuzhen Zhu, Yujie Yang, Guilin Chen, Matus Medo, Hui Tian, Shi-Min Cai
Methods used in information filtering and recommendation often rely on quantifying the similarity between objects or users. The used similarity metrics often suffer from similarity redundancies arising from correlations between objects' attributes. Based on an unweighted undirected object-user bipartite network, we propose a Corrected Redundancy-Eliminating similarity index (CRE) which is based on a spreading process on the network. Extensive experiments on three benchmark data sets-Movilens, Netflix and Amazon-show that when used in recommendation, the CRE yields significant improvements in terms of recommendation accuracy and diversity...
2017: PloS One
https://www.readbyqxmd.com/read/28749960/effects-of-warming-rate-acclimation-temperature-and-ontogeny-on-the-critical-thermal-maximum-of-temperate-marine-fish-larvae
#18
Marta Moyano, Caroline Candebat, Yannick Ruhbaum, Santiago Álvarez-Fernández, Guy Claireaux, José-Luis Zambonino-Infante, Myron A Peck
Most of the thermal tolerance studies on fish have been performed on juveniles and adults, whereas limited information is available for larvae, a stage which may have a particularly narrow range in tolerable temperatures. Moreover, previous studies on thermal limits for marine and freshwater fish larvae (53 studies reviewed here) applied a wide range of methodologies (e.g. the static or dynamic method, different exposure times), making it challenging to compare across taxa. We measured the Critical Thermal Maximum (CTmax) of Atlantic herring (Clupea harengus) and European seabass (Dicentrarchus labrax) larvae using the dynamic method (ramping assay) and assessed the effect of warming rate (0...
2017: PloS One
https://www.readbyqxmd.com/read/28749953/approaches-to-detect-genetic-effects-that-differ-between-two-strata-in-genome-wide-meta-analyses-recommendations-based-on-a-systematic-evaluation
#19
Thomas W Winkler, Anne E Justice, L Adrienne Cupples, Florian Kronenberg, Zoltán Kutalik, Iris M Heid
Genome-wide association meta-analyses (GWAMAs) conducted separately by two strata have identified differences in genetic effects between strata, such as sex-differences for body fat distribution. However, there are several approaches to identify such differences and an uncertainty which approach to use. Assuming the availability of stratified GWAMA results, we compare various approaches to identify between-strata differences in genetic effects. We evaluate type I error and power via simulations and analytical comparisons for different scenarios of strata designs and for different types of between-strata differences...
2017: PloS One
https://www.readbyqxmd.com/read/28749930/nontargeted-virus-sequence-discovery-pipeline-and-virus-clustering-for-metagenomic-data
#20
David Paez-Espino, Georgios A Pavlopoulos, Natalia N Ivanova, Nikos C Kyrpides
The analysis of large microbiome data sets holds great promise for the delineation of the biological and metabolic functioning of living organisms and their role in the environment. In the midst of this genomic puzzle, viruses, especially those that infect microbial communities, represent a major reservoir of genetic diversity with great impact on biogeochemical cycles and organismal health. Overcoming the limitations associated with virus detection directly from microbiomes can provide key insights into how ecosystem dynamics are modulated...
August 2017: Nature Protocols
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