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https://www.readbyqxmd.com/read/28545978/benralizumab-for-patients-with-mild-to-moderate-persistent-asthma-bise-a-randomised-double-blind-placebo-controlled-phase-3-trial
#1
Gary T Ferguson, J Mark FitzGerald, Eugene R Bleecker, Michel Laviolette, David Bernstein, Craig LaForce, Lyndon Mansfield, Peter Barker, Yanping Wu, Maria Jison, Mitchell Goldman
BACKGROUND: Benralizumab is a humanised, anti-interleukin 5 receptor α monoclonal antibody that directly and rapidly depletes eosinophils, reduces asthma exacerbations, and improves lung function for patients with severe eosinophilic asthma. The objective of this trial was to assess the safety and efficacy of benralizumab for patients with mild to moderate, persistent asthma. METHODS: In this randomised, double-blind, placebo-controlled, phase 3 trial, we recruited patients aged 18-75 years, weighing at least 40 kg, and with a postbronchodilator reversibility in forced expiratory volume in 1 s (FEV1) of at least 12% at screening, from 52 clinical research centres in six countries...
May 22, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28545946/body-mass-index-and-acoustic-voice-parameters-is-there-a-relationship
#2
Lourdes Bernadete Rocha de Souza, Marquiony Marques Dos Santos
INTRODUCTION: Specific elements such as weight and body volume can interfere in voice production and consequently in its acoustic parameters, which is why it is important for the clinician to be aware of these relationships. OBJECTIVE: To investigate the relationship between body mass index (BMI) and the average acoustic voice parameters. METHODS: Observational, cross-sectional descriptive study. The sample consisted of 84 women, aged between 18 and 40years, an average of 26...
May 6, 2017: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28544985/experiences-of-nursing-students-and-educators-during-the-co-construction-of-clinical-nursing-leadership-learning-activities-a-qualitative-research-and-development-study
#3
Laurence Ha, Jacinthe Pepin
BACKGROUND: Student voice posits that students' unique perspectives on teaching and learning can be used in conjunction with those of educators to create meaningful educational activities. OBJECTIVE: The study aimed to describe nursing students' and educators' experiences during the co-construction of educational activities involving clinical nursing leadership. DESIGN: Qualitative research and development model. SETTING: The study was conducted at a French-Canadian nursing faculty that provides a 3-year undergraduate program...
May 15, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/28543411/crowdsourcing-the-moral-limits-of-human-gene-editing
#4
Eric T Juengst
In 2015, a flourish of "alarums and excursions" by the scientific community propelled CRISPR/Cas9 and other new gene-editing techniques into public attention. At issue were two kinds of potential gene-editing experiments in humans: those making inheritable germ-line modifications and those designed to enhance human traits beyond what is necessary for health and healing. The scientific consensus seemed to be that while research to develop safe and effective human gene editing should continue, society's moral uncertainties about these two kinds of experiments needed to be better resolved before clinical trials of either type should be attempted...
May 2017: Hastings Center Report
https://www.readbyqxmd.com/read/28543038/central-voice-production-and-pathophysiology-of-spasmodic-dysphonia
#5
REVIEW
Niv Mor, Kristina Simonyan, Andrew Blitzer
OBJECTIVE: Our ability to speak is complex, and the role of the central nervous system in controlling speech production is often overlooked in the field of otolaryngology. In this brief review, we present an integrated overview of speech production with a focus on the role of central nervous system. The role of central control of voice production is then further discussed in relation to the potential pathophysiology of spasmodic dysphonia (SD). DATA SOURCES: Peer-review articles on central laryngeal control and SD were identified from PUBMED search...
May 23, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28542064/assessing-community-leadership-understanding-community-capacity-for-health-improvement
#6
Billie Castle, Monica Wendel, Brandy N Kelly Pryor, Monique Ingram
OBJECTIVE: The purpose of this study was to pilot a quantitative instrument to measure aspects of community leadership within an assessment framework. DESIGN: The instrument includes 14 Likert-type questions asking residents how they perceive leaders within 5 sectors: Louisville Metro Council/Mayor's Office, the faith community, education, business, and the civic sector. SETTING: Louisville/Jefferson County, Kentucky, has a population of about 743 000 residents...
July 2017: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/28541834/siblings-voices-a-prospective-investigation-of-experiences-with-a-dying-child
#7
Ceilidh Eaton Russell, Kimberley Widger, Laura Beaune, Alexandra Neville, Susan Cadell, Rose Steele, Adam Rapoport, Maria Rugg, Maru Barrera
Sibling relationships reflect a unique childhood bond, thus the impact on a sibling when a child is seriously ill or dying is profound. We conducted a prospective, longitudinal qualitative study over two years using interpretive descriptive methodology to understand siblings' perspectives when a brother or sister was dying at home or in hospital. The insights from the 10 siblings revealed complex experiences, both personal and with the ill child, their families, and peers. These experiences were paradoxically sources of strain and of support, revealing the importance of validation and normalization in assisting siblings to successfully navigate the experience...
May 25, 2017: Death Studies
https://www.readbyqxmd.com/read/28541742/warm-communication-style-strengthens-expectations-and-increases-perceived-improvement
#8
Xiaoyu He, Qinhua Sun, Cinnamon Stetler
Communication, both verbal and nonverbal, between healthcare providers and patients has been shown to affect treatment outcomes in clinical settings. Separately, accumulating research suggests a role for response expectations in altering treatment outcomes, especially in the context of inert or placebo treatment. However, few studies have examined which aspects of patient-provider communication strengthen expectations, leading to better treatment outcomes. The goal of this study is to test the effect of both verbal and nonverbal aspects of communication on response expectations and treatment outcomes in the context of a placebo exercise program...
May 25, 2017: Health Communication
https://www.readbyqxmd.com/read/28541724/book-review-the-poet-s-voice-in-the-making-of-mind-the-poet-s-voice-in-the-making-of-mind-meares-russell-new-york-routledge-2016-paperback-227-pages
#9
Nicholas John O'Connor
No abstract text is available yet for this article.
June 2017: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/28541243/czy-smog-ma-wp%C3%A5-yw-na-cz%C3%A4-sto%C3%A5-%C3%A4-wyst%C3%A4-powania-zaostrze%C3%A5-przewlek%C3%A5-ego-zapalenia-krtani-analiza-na-przyk%C3%A5-adzie-mieszka%C3%A5-c%C3%A3-w-wojew%C3%A3-dztwa-ma%C3%A5-opolskiego
#10
Remigiusz Ziarno, Anna Suska, Wojciech Kulinowski, Aleksandra Grudzień-Ziarno, Magdalena Kostrzon, Magdalena Paciorek, Jacek Składzień
INTRODUCTION: Due to dynamic industrialisation smog became a frequent phenomenon in most developing cities. According to the last WHO report from Global Urban Ambient Air Pollution Database, Krakow has been classified in the 11th place among the most polluted cities in Europe. It seems to be an urgent issue because of the influence of air pollution on the condition of upper respiratory tract. Materials & Methods: In December 2015 there were 141 patients aged 17-91 years with upper respiratory tract diseases admitted to the phoniatric outpatient clinic in the University Hospital in Cracow...
June 30, 2017: Otolaryngologia Polska
https://www.readbyqxmd.com/read/28540785/single-session-high-intensity-focussed-ablation-hifu-versus-open-cervical-hemithyroidectomy-for-benign-thyroid-nodule-analysis-on-early-efficacy-safety-and-voice-quality
#11
Brian H H Lang, Carlos K H Wong, Estella P M Ma
BACKGROUND: High intensity focussed ultrasound (HIFU) is a promising non-surgical treatment for symptomatic benign thyroid nodule. We aimed to compare early efficacy, safety and voice quality between HIFU ablation and open thyroidectomy. METHODS: Consecutive patients who underwent single-session HIFU ablation or a hemithyroidectomy for symptomatic benign thyroid nodule were included. The 6-month extent of nodule shrinkage, symptom improvement score, thyroid function, hospital stay and cost were compared between the two procedures...
March 24, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28540530/voice-outcomes-in-surgical-repair-of-zenker-s-diverticulum
#12
Stephen Schoeff, Michael Freeman, James Daniero
The purpose of the study was to define the impact of Zenker's diverticula on voice and potential benefit from repair. Retrospective chart review of prospectively collected data from eleven patients with a Zenker's diverticulum treated surgically in a tertiary care center from November 2014 through January 2016. The voice handicap index-10 (VHI-10) and eating assessment tool-10 (EAT-10) questionnaires were collected as part of pre- and post-operative evaluation, with an average post-operative follow-up of 69 days...
May 25, 2017: Dysphagia
https://www.readbyqxmd.com/read/28539898/speak-my-language-and-i-will-remember-your-face-better-an-erp-study
#13
Cristina Baus, Jesús Bas, Marco Calabria, Albert Costa
Here we investigated how the language in which a person addresses us, native or foreign, influences subsequent face recognition. In an old/new paradigm, we explored the behavioral and electrophysiological activity associated with face recognition memory. Participants were first presented with faces accompanied by voices speaking either in their native (NL) or foreign language (FL). Faces were then presented in isolation and participants decided whether the face was presented before (old) or not (new). The results revealed that participants were more accurate at remembering faces previously paired with their native as opposed to their FL...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28539210/design-and-testing-of-a-controlled-electromagnetic-spinal-cord-impactor-for-use-in-large-animal-models-of-acute-traumatic-spinal-cord-injury
#14
Rory J Petteys, Steven M Spitz, Hasan Syed, R Andrew Rice, Rachel Sarabia-Estrada, C Rory Goodwin, Daniel M Sciubba, Brett A Freedman
BACKGROUND: Spinal cord injury (SCI) causes debilitating neurological dysfunction and has been observed in warfighters injured in IED blasts. Clinical benefit of SCI treatment remains elusive and better large animal models are needed to assess treatment options. Here, we describe a controlled electromagnetic spinal cord impactor for use in large animal models of SCI. METHODS: A custom spinal cord impactor and platform were fabricated for large animals (e.g., pig, sheep, dog, etc...
May 20, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28539111/written-versus-verbal-consent-a-qualitative-study-of-stakeholder-views-of-consent-procedures-used-at-the-time-of-recruitment-into-a-peripartum-trial-conducted-in-an-emergency-setting
#15
J Lawton, N Hallowell, C Snowdon, J E Norman, K Carruthers, F C Denison
BACKGROUND: Obtaining prospective written consent from women to participate in trials when they are experiencing an obstetric emergency is challenging. Alternative consent pathways, such as gaining verbal consent at enrolment followed, later, by obtaining written consent, have been advocated by some clinicians and bioethicists but have received little empirical attention. We explored women's and staff views about the consent procedures used during the internal pilot of a trial (GOT-IT), where the protocol permitted staff to gain verbal consent at recruitment...
May 24, 2017: BMC Medical Ethics
https://www.readbyqxmd.com/read/28538897/do-you-know-this-syndrome-werner-syndrome
#16
Özlem Bilgiç
Werner syndrome is a rare autosomal recessive disorder, caused by mutations in the WRN gene. Clinical findings include: senile appearance, short stature, grey hair, alopecia, bird-like face, scleroderma-like skin changes, skin ulcers, voice abnormalities, cataracts, osteoporosis, type 2 diabetes mellitus, ischemic heart disease and hypogonadism. The syndrome begins to become apparent in adolescence but it is usually diagnosed in the third or fourth decade of life. Since the patients usually die by the age of 40-50 years related to malignant neoplasms or atherosclerotic complications, they should be closely followed and treated for complications...
March 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28538820/communication-resources-of-managers-and-business-professionals
#17
Clarissa Araujo Pedrotti, Mara Behlau
Purpose: To analyze the communication resources reported by managers in the business environment and compare the resources used to those reported by business professionals. Methods: 82 professionals volunteered to participate in the research, divided into 50 managers (MP) and 32 business professionals (BP) from industry section in Caxias do Sul and the surrounding region (Brazil). A questionnaire with 4 topics was used: personal data, self-assessment of communicative behavior, self-assessment of communicative resources, and selection of positive and negative resources influencing communication...
May 22, 2017: CoDAS
https://www.readbyqxmd.com/read/28536807/prognostic-factors-for-enteroatmospheric-fistula-in-open-abdomen-treated-with-negative-pressure-wound-therapy-a-multicentre-experience
#18
Guillaume Giudicelli, A Rossetti, C Scarpa, N C Buchs, R Hompes, R J Guy, K Ukegjini, P Morel, F Ris, M Adamina
BACKGROUND: Reductions in mortality were reported with negative pressure wound therapy for laparostomy. However, some authors have voiced concern over an increased risk of enteroatmospheric fistulae. In this retrospective study, we hypothesized that surgical and metabolic derangements could increase the incidence of enteroatmospheric fistulae. We aimed to assess our experience and report long-term outcomes. METHODS: A multicentre review of all patients with a laparostomy managed with negative pressure wound therapy between 2005 and 2015 was undertaken...
May 23, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28536767/improving-efficiency-in-the-radiology-department
#19
REVIEW
Alexander J Towbin, Laurie A Perry, David B Larson
The modern radiology department is built around the flow of information. Ordering providers request imaging studies to be performed, technologists complete the work required to perform the imaging studies, and radiologists interpret and report on the imaging findings. As each of these steps is performed, data flow between multiple information systems, most notably the radiology information system (RIS), the picture archiving and communication system (PACS) and the voice dictation system. Even though data flow relatively seamlessly, the majority of our systems and processes are inefficient...
June 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28536089/smart-devices-for-older-adults-managing-chronic-disease-a-scoping-review
#20
REVIEW
Ben Yb Kim, Joon Lee
BACKGROUND: The emergence of smartphones and tablets featuring vastly advancing functionalities (eg, sensors, computing power, interactivity) has transformed the way mHealth interventions support chronic disease management for older adults. Baby boomers have begun to widely adopt smart devices and have expressed their desire to incorporate technologies into their chronic care. Although smart devices are actively used in research, little is known about the extent, characteristics, and range of smart device-based interventions...
May 23, 2017: JMIR MHealth and UHealth
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