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Brain AND childhood and adolescence development

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https://www.readbyqxmd.com/read/27872489/experience-driven-differences-in-childhood-cortisol-predict-affect-relevant-brain-function-and-coping-in-adolescent-monozygotic-twins
#1
Cory A Burghy, Michelle E Fox, M Daniela Cornejo, Diane E Stodola, Sasha L Sommerfeldt, Cecilia A Westbrook, Carol Van Hulle, Nicole L Schmidt, H Hill Goldsmith, Richard J Davidson, Rasmus M Birn
Stress and emotion involve diverse developmental and individual differences. Partially attributed to the development of the prefrontal cortex (PFC), the amygdala, and hypothalamic-pituitary-adrenal axis, the precise genetic and experiential contributions remain unknown. In previous work, childhood basal cortisol function predicted adolescent resting-state functional connectivity (rs-FC) and psychopathology. To parse experience-driven (non-genetic) contributions, we investigated these relations with a monozygotic (MZ) twin design...
November 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27847299/an-mrspec-database-query-and-visualization-engine-with-applications-as-a-clinical-diagnostic-and-research-tool
#2
Filip Miscevic, Justin Foong, Benjamin Schmitt, Susan Blaser, Michael Brudno, Andreas Schulze
PURPOSE: Proton magnetic resonance spectroscopy (MRspec), one of the very few techniques for in vivo assessment of neuro-metabolic profiles, is often complicated by lack of standard population norms and paucity of computational tools. METHODS: 7035 scans and clinical information from 4430 pediatric patients were collected from 2008 to 2014. Scans were conducted using a 1.5T (n=3664) or 3T scanner (n=3371), and with either a long (144ms, n=5559) or short echo time (35ms, n=1476)...
November 9, 2016: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/27843501/visual-memory-profile-in-22q11-2-microdeletion-syndrome-are-there-differences-in-performance-and-neurobiological-substrates-between-tasks-linked-to-ventral-and-dorsal-visual-brain-structures-a-cross-sectional-and-longitudinal-study
#3
Mathilde Bostelmann, Maude Schneider, Maria Carmela Padula, Johanna Maeder, Marie Schaer, Elisa Scariati, Martin Debbané, Bronwyn Glaser, Sarah Menghetti, Stephan Eliez
BACKGROUND: Children affected by the 22q11.2 deletion syndrome (22q11.2DS) have a specific neuropsychological profile with strengths and weaknesses in several cognitive domains. Specifically, previous evidence has shown that patients with 22q11.2DS have more difficulties memorizing faces and visual-object characteristics of stimuli. In contrast, they have better performance in visuo-spatial memory tasks. The first focus of this study was to replicate these results in a larger sample of patients affected with 22q11...
2016: Journal of Neurodevelopmental Disorders
https://www.readbyqxmd.com/read/27819440/self-reported-parenting-style-is-associated-with-children-s-inflammation-and-immune-activation
#4
Michelle L Byrne, Paul B Badcock, Julian G Simmons, Sarah Whittle, Adam Pettitt, Craig A Olsson, Lisa K Mundy, George C Patton, Nicholas B Allen
Family environments and parenting have been associated with inflammation and immune activation in children and adolescents; however, it remains unclear which specific aspects of parenting drive this association. In this study, we cross-sectionally examined the association between 5 discrete parenting styles and inflammation and immune activation in late childhood. Data were drawn from 102 families (55 with female children, mean age 9.50 years, SD = 0.34) participating in the Imaging Brain Development in the Childhood to Adolescence Transition Study...
November 7, 2016: Journal of Family Psychology: JFP
https://www.readbyqxmd.com/read/27778230/an-iron-deficient-diet-during-development-induces-oxidative-stress-in-relation-to-age-and-gender-in-wistar-rats
#5
Patricia Vieyra-Reyes, Diana Millán-Aldaco, Marcela Palomero-Rivero, Clementina Jiménez-Garcés, Margarita Hernández-González, Javier Caballero-Villarraso
Iron is a trace element and a structural part of antioxidant enzymes, and its requirements vary according to age and gender. We hypothesized that iron deficiency (ID) leads to an increase in free radicals which mainly affect the brain, and the severity of damage would therefore be dependent on age and gender. Two groups of Wistar rats were evaluated evolutionarily: 100 rats (50 males; 50 females) with ID diet and 100 rats (50 males; 50 females) with standard diet. Both groups were offspring from mothers who were previously under the same dietary intervention...
October 24, 2016: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/27766459/absolute-power-spectral-density-changes-in-the-magnetoencephalographic-activity-during-the-transition-from-childhood-to-adulthood
#6
Carlos M Gómez, Elena I Rodríguez-Martínez, Alberto Fernández, Fernando Maestú, Jesús Poza, Carlos Gómez
The aim of this study was to define the pattern of reduction in absolute power spectral density (PSD) of magnetoencephalography (MEG) signals throughout development. Specifically, we wanted to explore whether the human skull's high permeability for electromagnetic fields would allow us to question whether the pattern of absolute PSD reduction observed in the human electroencephalogram is due to an increase in the skull's resistive properties with age. Furthermore, the topography of the MEG signals during maturation was explored, providing additional insights about the areas and brain rhythms related to late maturation in the human brain...
October 20, 2016: Brain Topography
https://www.readbyqxmd.com/read/27735078/the-effects-of-prenatal-h1n1-infection-at-e16-on-fmrp-glutamate-gaba-and-reelin-signaling-systems-in-developing-murine-cerebellum
#7
S Hossein Fatemi, Timothy D Folsom, Stephanie B Liesch, Rachel E Kneeland, Mahtab Karkhane Yousefi, Paul D Thuras
Prenatal viral infection has been identified as a potential risk factor for the development of neurodevelopmental disorders such as schizophrenia and autism. Additionally, dysfunction in gamma-aminobutyric acid, Reelin, and fragile X mental retardation protein (FMRP)-metabotropic glutamate receptor 5 signaling systems has also been demonstrated in these two disorders. In the current report, we have characterized the developmental profiles of selected markers for these systems in cerebella of mice born to pregnant mice infected with human influenza (H1N1) virus on embryonic day 16 or sham-infected controls using SDS-PAGE and Western blotting techniques and evaluated the presence of abnormalities in the above-mentioned markers during brain development...
October 13, 2016: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27696278/why-parametric-measures-are-critical-for-understanding-typical-and-atypical-cognitive-development
#8
Marie Arsalidou, Nancie Im-Bolter
Children's cognitive abilities improve significantly over childhood and adolescence. We know from behavioral research that core cognitive processes such as working memory and mental attention improve significantly across development. Functional magnetic resonance imaging (fMRI) allows for investigating the typically developing, living brain in action. In the last twenty years we have learned a great deal about brain correlates associated with how adults hold and manipulate information in mind, however, neurocognitive correlates across development remain inconsistent...
October 1, 2016: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/27676968/validation-and-psychometric-properties-of-the-french-version-of-the-child-and-adolescent-scale-of-participation-casp-in-a-sample-of-children-with-acquired-brain-injury
#9
Marieke Chamberon, Corinne Catale, Bernadette Kerrouche, Hanna Touré, Anne Laurent-Vannier, Dominique Brugel, Emmanuelle Pineau-Chardon, Aude Mariller, Ouarda Benkhaled, Virginie Kieffer, Miriam Beauchamp, Mathilde Chevignard
OBJECTIVE: Childhood acquired brain injury (ABI) is the leading cause of acquired disability in childhood, with significant consequences on independence, academic achievement and participation. The "Child and Adolescent Scale of Participation" (CASP; Bedell 2004) has been specifically developed to assess participation following childhood ABI. The aim of this study was to examine the psychometric properties of the French version of the Child and Adolescent Scale of Participation. MATERIAL/PATIENTS AND METHODS: Cross-sectional, monocentric study...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27676779/academic-outcome-participation-and-health-related-quality-of-life-following-childhood-severe-traumatic-brain-injury-results-of-a-prospective-longitudinal-study-the-seven-year-follow-up-of-the-tge-cohort
#10
Mathilde Chevignard, Leila Francillette, Hanna Toure, Dominique Brugel, Philippe Meyer, Anne Laurent Vannier, Marion Opatowski, Laurence Watier
OBJECTIVE: Childhood traumatic brain injury (TBI) is the first cause of death and acquired disability and it represents a major public health issue. Childhood severe TBI can lead to motor, cognitive, behavioural and social cognition deficits, which have consequences on academic achievement, social integration, participation and quality of life. Consequences may only appear after a delay, when the skills are supposed to be fully developed. The aim of this study was to prospectively assess academic outcome, health-related quality of life (HRQoL), amount of ongoing care and participation, following childhood severe traumatic brain injury (TBI) over 7-8years post-injury, in comparison with a matched uninjured control group...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27647051/childhood-abuse-and-reduced-cortical-thickness-in-brain-regions-involved-in-emotional-processing
#11
Andrea L Gold, Margaret A Sheridan, Matthew Peverill, Daniel S Busso, Hilary K Lambert, Sonia Alves, Daniel S Pine, Katie A McLaughlin
BACKGROUND: Alterations in gray matter development represent a potential pathway through which childhood abuse is associated with psychopathology. Several prior studies find reduced volume and thickness of prefrontal (PFC) and temporal cortex regions in abused compared with nonabused adolescents, although most prior research is based on adults and volume-based measures. This study tests the hypothesis that child abuse, independent of parental education, predicts reduced cortical thickness in prefrontal and temporal cortices as well as reduced gray mater volume (GMV) in subcortical regions during adolescence...
October 2016: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/27644039/age-related-differences-in-cortical-thickness-vary-by-socioeconomic-status
#12
Luciane R Piccolo, Emily C Merz, Xiaofu He, Elizabeth R Sowell, Kimberly G Noble
Recent findings indicate robust associations between socioeconomic status (SES) and brain structure in children, raising questions about the ways in which SES may modify structural brain development. In general, cortical thickness and surface area develop in nonlinear patterns across childhood and adolescence, with developmental patterns varying to some degree by cortical region. Here, we examined whether age-related nonlinear changes in cortical thickness and surface area varied by SES, as indexed by family income and parental education...
2016: PloS One
https://www.readbyqxmd.com/read/27639358/diffusion-kurtosis-metrics-as-biomarkers-of-microstructural-development-a-comparative-study-of-a-group-of-children-and-a-group-of-adults
#13
Farida Grinberg, Ivan I Maximov, Ezequiel Farrher, Irene Neuner, Laura Amort, Heike Thönneßen, Eileen Oberwelland, Kerstin Konrad, N Jon Shah
The most common modality of diffusion MRI used in the ageing and development studies is diffusion tensor imaging (DTI) providing two key measures, fractional anisotropy and mean diffusivity. Here, we investigated diffusional changes occurring between childhood (average age 10.3 years) and mitddle adult age (average age 54.3 years) with the help of diffusion kurtosis imaging (DKI), a recent novel extension of DTI that provides additional metrics quantifying non-Gaussianity of water diffusion in brain tissue...
September 14, 2016: NeuroImage
https://www.readbyqxmd.com/read/27638083/vertigo-and-dizziness-in-children
#14
K Jahn
Vertigo and dizziness of at least moderate severity occur in >5% of school-aged children and cause considerable restrictions in participation in school and leisure activity. More than 50% of dizzy children also have headache. Vestibular migraine and benign paroxysmal vertigo as a migraine precursor are the most common diagnoses in dizziness clinics for children and adolescents. They account for 30-60% of diagnoses. Other common causes are somatoform, orthostatic, or posttraumatic dizziness. All other disorders that are known to cause vertigo and dizziness in adults also occur in children, but incidence rates are usually lower...
2016: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/27604726/pediatric-rodent-models-of-traumatic-brain-injury
#15
Bridgette D Semple, Jaclyn Carlson, Linda J Noble-Haeusslein
Due to a high incidence of traumatic brain injury (TBI) in children and adolescents, age-specific studies are necessary to fully understand the long-term consequences of injuries to the immature brain. Preclinical and translational research can help elucidate the vulnerabilities of the developing brain to insult, and provide model systems to formulate and evaluate potential treatments aimed at minimizing the adverse effects of TBI. Several experimental TBI models have therefore been scaled down from adult rodents for use in juvenile animals...
2016: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27575975/reproductive-parameters-of-female-wistar-rats-treated-with-methylphenidate-during-development
#16
Bruno Garcia Montagnini, Kennia Moura Silveira, Bruna Caroline Pierone, Nathália de Azevedo Camim, Janete Aparecida Anselmo-Franci, Suzana de Fátima Paccola Mesquita, Ana Carolina Inhasz Kiss, Daniela Cristina Ceccatto Gerardin
Methylphenidate (MPH), a psychoactive agent that acts mainly by blocking the uptake of dopamine, is the main drug used to treat Attention Deficit Hyperactivity Disorder in children and adolescents. During development, important changes in brain architecture and plasticity occur, these changes, sensitive to exposure to stimulant drugs, are important in the control of GnRH secretion, influencing the release of sex hormones throughout the ovarian cycle. This study investigated the effects of repeated treatment with MPH during development on reproductive parameters of adult female rats...
August 26, 2016: Physiology & Behavior
https://www.readbyqxmd.com/read/27573879/heightened-extended-amygdala-metabolism-following-threat-characterizes-the-early-phenotypic-risk-to-develop-anxiety-related-psychopathology
#17
A J Shackman, A S Fox, J A Oler, S E Shelton, T R Oakes, R J Davidson, N H Kalin
Children with an anxious temperament are prone to heightened shyness and behavioral inhibition (BI). When chronic and extreme, this anxious, inhibited phenotype is an important early-life risk factor for the development of anxiety disorders, depression and co-morbid substance abuse. Individuals with extreme anxious temperament often show persistent distress in the absence of immediate threat and this contextually inappropriate anxiety predicts future symptom development. Despite its clear clinical relevance, the neural circuitry governing the maladaptive persistence of anxiety remains unclear...
August 30, 2016: Molecular Psychiatry
https://www.readbyqxmd.com/read/27543114/type-and-timing-of-adverse-childhood-experiences-differentially-affect-severity-of-ptsd-dissociative-and-depressive-symptoms-in-adult-inpatients
#18
Inga Schalinski, Martin H Teicher, Daniel Nischk, Eva Hinderer, Oliver Müller, Brigitte Rockstroh
BACKGROUND: A dose-dependent effect of Adverse Childhood Experiences (ACE) on the course and severity of psychiatric disorders has been frequently reported. Recent evidence indicates additional impact of type and timing of distinct ACE on symptom severity experienced in adulthood, in support of stress-sensitive periods in (brain) development. The present study seeks to clarify the impact of ACE on symptoms that are often comorbid across various diagnostic groups: symptoms of posttraumatic stress disorder (PTSD), shutdown dissociation and depression...
2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27520466/association-between-maternal-nutritional-status-in-pregnancy-and-offspring-cognitive-function-during-childhood-and-adolescence-a-systematic-review
#19
Sargoor R Veena, Catharine R Gale, Ghattu V Krishnaveni, Sarah H Kehoe, Krishnamachari Srinivasan, Caroline Hd Fall
BACKGROUND: The mother is the only source of nutrition for fetal growth including brain development. Maternal nutritional status (anthropometry, macro- and micro-nutrients) before and/or during pregnancy is therefore a potential predictor of offspring cognitive function. The relationship of maternal nutrition to offspring cognitive function is unclear. This review aims to assess existing evidence linking maternal nutritional status with offspring cognitive function. METHODS: Exposures considered were maternal BMI, height and weight, micronutrient status (vitamins D, B12, folate and iron) and macronutrient intakes (carbohydrate, protein and fat)...
August 12, 2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27503447/effects-of-marijuana-use-on-brain-structure-and-function-neuroimaging-findings-from-a-neurodevelopmental-perspective
#20
T Brumback, N Castro, J Jacobus, S Tapert
Marijuana, behind only tobacco and alcohol, is the most popular recreational drug in America with prevalence rates of use rising over the past decade. A wide range of research has highlighted neurocognitive deficits associated with marijuana use, particularly when initiated during childhood or adolescence. Neuroimaging, describing alterations to brain structure and function, has begun to provide a picture of possible mechanisms associated with the deleterious effects of marijuana use. This chapter provides a neurodevelopmental framework from which recent data on brain structural and functional abnormalities associated with marijuana use is reviewed...
2016: International Review of Neurobiology
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