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Temporal arteritis

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https://www.readbyqxmd.com/read/29451658/clinical-correlation-of-biopsy-results-in-patients-with-temporal-arteritis
#1
Volkan Yuksel, Orkut Guclu, Ebru Tastekin, Umit Halici, Serhat Huseyin, Volkan Inal, Suat Canbaz
OBJECTIVE: Temporal arteritis is systemic vasculitis of medium and large sized vessels. The lowest incidence rates were reported in Turkey, Japan and Israel. We aimed to investigate the results of patients with biopsy-proven temporal arteritis and those classified according to the American College of Rheumatology criteria from a low-incidence region for temporal arteritis. The results of our study are noteworthy, since there is limited data on pathologic diagnosis of temporal arteritis in Turkey...
November 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/29436372/the-acupuncture-therapeutic-approach-in-temporal-arteritis-vasculitis-a-case-report
#2
Yılmaz Sezgin
Temporal arteritis is a form of vasculitis that involves the large and medium-diameter arteries and leads to progressive headache. Symptoms may be accompanied by vision disorder, subfebrile temperature, fatigue, lack of appetite, weight loss, sweating and joint pains. While cortisone therapy reduces the symptoms, its effects in terms of improving quality of life are limited. We elected to benefit from the effects of acupuncture in order to reduce symptoms and increase quality of life in a case of temporal arteritis, a chronic disease...
December 26, 2017: Journal of Acupuncture and Meridian Studies
https://www.readbyqxmd.com/read/29426439/characterization-of-serological-markers-of-healed-healing-arteritis-and-giant-cell-arteritis
#3
Vinay Kansal, Sangsu Han, James Farmer, Danah Albreiki
OBJECTIVE: Temporal artery biopsy (TAB) is the gold standard for confirming the diagnosis of giant cell arteritis (GCA) when positive. However, the clinical significance of healed/healing (HH) arterial injury on TAB is not well understood. The purpose of this study was to evaluate the clinical significance of this finding on TAB by determining its association with seromarkers typically predictive of GCA. DESIGN: Single-centre, retrospective, investigational cohort study...
February 2018: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/29414433/il-6-expression-is-correlated-with-increased-t-cell-proliferation-and-survival-in-the-arterial-wall-in-giant-cell-arteritis
#4
Sukhbir Manku, Wendy Wong, Zongshu Luo, Michael A Seidman, Zainab Alabdurubalnabi, Kevin Rey, Winnie Enns, J Antonio Avina-Zubieta, Kamran Shojania, Jonathan C Choy
Giant cell arteritis (GCA) is the most common vasculitis in adults affecting large and medium-sized arteries. IL-6 and T cell accumulation within the arterial wall contribute to the pathogenesis of GCA, and blockade of IL-6 activity is efficacious in its treatment. We examined the relationship between levels of IL-6 expression and immunological processes that control the expansion of T cells in GCA-positive temporal artery biopsies. CD4 T cells accumulated in clusters within the media and deep intima of all GCA lesions...
January 9, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29408476/a-case-of-giant-cell-arteritis-associated-with-a-culture-proven-coxiella-burnetii-aortitis
#5
S De Worm, J B Giot, C Courtoy, E Gillet, Sophie Amrane, P Huynen, M Van Esbroeck, E Prudent, H Lepidi, Matthieu Million, M Moutschen, Didier Raoult
We report a case of proven Coxiella burnetii aortitis, possibly associated with a giant cell arteritis (GCA). A seventy-two-year-old man, who is a hunter, presented with weight loss, fevers, jaw claudication and hardened temporal arteries associated with a persistent inflammatory syndrome and an arteritis of the whole aorta including the brachiocephalic arteries on the 18F-FDG PET/CT. A diagnosis of GCA was retained and a treatment with prednisolone was started. Given an aneurysm of the abdominal aorta, the patient underwent replacement of abdominal aorta with an allograft...
February 2, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29365233/ear-pain-diagnosing-common-and-uncommon-causes
#6
John Scott Earwood, Tyler Sherrod Rogers, Nicholas Alan Rathjen
Otalgia (ear pain) is a common presentation in the primary care setting with many diverse causes. Pain that originates from the ear is called primary otalgia, and the most common causes are otitis media and otitis externa. Examination of the ear usually reveals abnormal findings in patients with primary otalgia. Pain that originates outside the ear is called secondary otalgia, and the etiology can be difficult to establish because of the complex innervation of the ear. The most common causes of secondary otalgia include temporomandibular joint syndrome and dental infections...
January 1, 2018: American Family Physician
https://www.readbyqxmd.com/read/29361164/central-retinal-vein-occlusion-in-temporal-arteritis-red-sign-or-red-herring
#7
Lisa Kaly, Gleb Slobodin, Doron Rimar, Michael Rozenbaum, Nina Boulman, Shira Ginsberg, Abed Awisat, Karin Zilber, Haya Hussein, Izthak Rosner
No abstract text is available yet for this article.
January 17, 2018: Rheumatology
https://www.readbyqxmd.com/read/29358285/eular-recommendations-for-the-use-of-imaging-in-large-vessel-vasculitis-in-clinical-practice
#8
Christian Dejaco, Sofia Ramiro, Christina Duftner, Florent L Besson, Thorsten A Bley, Daniel Blockmans, Elisabeth Brouwer, Marco A Cimmino, Eric Clark, Bhaskar Dasgupta, Andreas P Diamantopoulos, Haner Direskeneli, Annamaria Iagnocco, Thorsten Klink, Lorna Neill, Cristina Ponte, Carlo Salvarani, Riemer H J A Slart, Madeline Whitlock, Wolfgang A Schmidt
To develop evidence-based recommendations for the use of imaging modalities in primary large vessel vasculitis (LVV) including giant cell arteritis (GCA) and Takayasu arteritis (TAK).European League Against Rheumatism (EULAR) standardised operating procedures were followed. A systematic literature review was conducted to retrieve data on the role of imaging modalities including ultrasound, MRI, CT and [18F]-fluorodeoxyglucose positron emission tomography (PET) in LVV. Based on evidence and expert opinion, the task force consisting of 20 physicians, healthcare professionals and patients from 10 EULAR countries developed recommendations, with consensus obtained through voting...
January 22, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29349436/superficial-temporal-artery-aneurysm-associated-with-immunoglobulin-g4-related-disease
#9
Sosei Kuma, Tsubasa Takeshima, Takefumi Ohga, Tadahiro Nozoe, Katsuo Sueishi
A 68-year-old man was admitted because of a pulsatile mass and pain in the left temporal region, and computed tomography demonstrated the superficial temporal artery aneurysm. He underwent aneurysmectomy, and pathologic investigation revealed marked thickness of the adventitia with substantial plasmacyte infiltration. On immunoglobulin G4 (IgG4) immunohistochemistry, IgG4-positive lymphocytes were scattered in the adventitia, and biochemical tests revealed elevation of IgG4 (200 mg/dL). The case satisfied the criteria for both giant cell arteritis and IgG4-related disease (IgG4-RD)...
December 2017: Journal of Vascular Surgery Cases and Innovative Techniques
https://www.readbyqxmd.com/read/29344073/bilateral-non-arteritic-anterior-ischaemic-optic-neuropathy-as-the-presentation-of-systemic-amyloidosis
#10
M Z Kanaan, A R Lorenzi, N Thampy, R Pandit, Margaret Dayan
A 75-year-old hypertensive female with stable idiopathic intermediate uveitis presented with bilateral sequential optic neuropathy with optic disc swelling. The optic neuropathy in the first affected eye (right) was thought to be due to non-arteritic anterior ischaemic optic neuropathy (NAION). Asymptomatic left optic disc swelling was found at routine review 2 months later, and a diagnosis of giant cell arteritis (GCA) was sought. Temporal artery duplex ultrasound showed the "halo sign," but a subsequent temporal artery biopsy showed light-chain (AL) amyloidosis with no signs of giant cell arteritis...
December 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29343075/tocilizumab-in-giant-cell-arteritis-a-real-life-retrospective-study
#11
Gianfranco Vitiello, Carolina Orsi Battaglini, Giulia Carli, Anna Radice, Andrea Matucci, Alessandra Vultaggio, Catia Olianti, Paola Parronchi, Enrico Maggi, Daniele Cammelli
This study aims to evaluate (1) the efficacy and safety of tocilizumab (TCZ) as a steroid-sparing agent in patients with giant cell arteritis (GCA) and (2) the usefulness of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) in the follow-up and to detect disease activity. We retrospectively evaluated 12 patients with GCA treated with TCZ (8 mg/kg/mo). Pre- and posttherapy data about clinical signs and symptoms, laboratory results, FDG-PET imaging study, and the mean glucocorticoid (GC) dose were used to assess disease activity...
January 1, 2018: Angiology
https://www.readbyqxmd.com/read/29332573/torsades-de-pointes-in-patients-with-polymyalgia-rheumatica
#12
Pietro Enea Lazzerini, Iacopo Bertolozzi, Maurizio Acampa, Rosella Fulceri, Franco Laghi-Pasini, Pier Leopoldo Capecchi
Polymyalgia rheumatica (PMR) represents the most common inflammatory rheumatic disease of the elderly. It is characterized by synovitis of proximal joints and extra-articular synovial structures, along with chronic high-grade systemic inflammation. PMR is closely related to giant cell arteritis (GCA), a large-vessel vasculitis that involves the major branches of the aorta, particularly the extracranial branches of carotid artery including temporal arteries. It is currently believed that PMR and GCA may represent different manifestations of the same disease process...
January 10, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29322494/common-primary-and-secondary-causes-of-headache-in-the-elderly
#13
Tara L Sharma
OBJECTIVE/BACKGROUND: Headache in the elderly, defined as individuals aged 65 and older, although less prevalent than younger individuals, can present as a diagnostic challenge, given the increase in potentially fatal diseases within this population. METHODS: These individuals require a complete history, neurological examination, and assessment of potential secondary causes of headaches. RESULTS: Secondary causes include temporal or giant cell arteritis, subdural hematomas, central nervous system (CNS) tumors, strokes, and CNS infections...
January 11, 2018: Headache
https://www.readbyqxmd.com/read/29290619/-a-giant-cell-arteritis-revealing-a-goodpasture-s-syndrome
#14
Pascaline M Alix, Amélie Belloi, Émilie Berthoux, Frédérique Dijoud, Emmanuel Villar, Caroline Pariset
Goodpasture's syndrome is a triad of anti-glomerular basement membrane (anti-GBM) circulating antibodies, glomerulonephritis and pulmonary hemorrhage. We reported a 65-year-old woman with headaches, asthenia and weight loss. Giant cell arteritis was confirmed by temporal artery biopsy. The patient had associated renal condition with moderate acute renal failure, proteinuria and haematuria. Renal biopsy showed extracapillary glomerulonephritis and linear staining of immunoglobulins G along glomerular basement membrane...
December 28, 2017: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29250759/orbital-cellulitis-presenting-as-giant-cell-arteritis-a-case-report
#15
Yu-Wei Hsu, Fu-Chi Yang, Jiunn-Tay Lee, Hung-Wen Kao, Chia-Kuang Tsai
PURPOSE: To present a case of orbital cellulitis initially mimicking giant cell arteritis. CASE REPORT: An 80-year-old man with a history of hypertension and type 2 diabetes mellitus was referred with a prominent progressive headache over the right temporal and periorbital areas. Non-contrast brain CT results were normal, but ESR was elevated. Giant cell arteritis was suspected initially. However, the symptoms progressed under oral corticosteroid therapy. The subsequent brain MRI with contrast revealed extensive contrast enhancement along the right optic nerve and optic canal with a rim-enhancing lesion in the posterior aspect of the optic nerve...
June 15, 2017: Acta Neurologica Taiwanica
https://www.readbyqxmd.com/read/29236347/the-full-blood-count-as-an-ancillary-test-to-support-the-diagnosis-of-giant-cell-arteritis
#16
Lawrence J Oh, Eugene Wong, Juliana Andrici, Peter McCluskey, James E H Smith, Anthony J Gill
BACKGROUND: Temporal artery biopsy is considered the investigation of choice to definitively diagnose giant cell arteritis in patients with compatible symptoms. However it is invasive and not completely sensitive. Serum markers, particularly ESR, can be supportive but are not definitive in individual cases. AIMS: We sought to investigate whether indices derived from the full blood count including neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), were associated with a positive biopsy in patients with suspected giant cell arteritis...
December 13, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/29234910/ultrasonography-of-occipital-arteries-to-diagnose-giant-cell-arteritis-a-case-series-and-literature-review
#17
REVIEW
Jonathan Pinnell, Carl Tiivas, Phillip Perkins, Tim Blake, Shanmugam Saravana, Shirish Dubey
We describe four cases of giant cell arteritis (GCA) that presented with occipital headache in the last 6 months. Typical ultrasound features of GCA were found in the occipital arteries which helped to confirm the diagnosis. One patient had already suffered significant visual loss by the time the diagnosis was made, reflecting the similarity in prognosis to the more typical GCA patients. These cases prompted a review of the literature to evaluate the evidence regarding the use of occipital artery ultrasonography in the investigation of GCA...
December 12, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29225921/geo-epidemiology-of-temporal-artery-biopsy-positive-giant-cell-arteritis-in-australia-and-new-zealand-is-there-a-seasonal-influence
#18
Elisabeth De Smit, Linda Clarke, Paul G Sanfilippo, Tony R Merriman, Matthew A Brown, Catherine L Hill, Alex W Hewitt
Objective: Previous studies, although inconclusive, have suggested possible associations of environmental risk factors with the development of giant cell arteritis (GCA). We aim to investigate seasonal influence on the incidence of GCA across Australia and New Zealand. Methods: In establishing an international study to investigate the molecular aetiology of GCA, archived temporal artery biopsy (TAB) specimens primarily from Australia and New Zealand were obtained...
2017: RMD Open
https://www.readbyqxmd.com/read/29217029/development-of-a-predictive-model-for-temporal-artery-biopsies
#19
Ezekiel Weis, Andrew Toren, David Jordan, Vivek Patel, Steven Gilberg
OBJECTIVE: Temporal artery biopsy is a critical, relatively safe, and reliable test in the diagnosis of temporal arteritis. Yet, a clarification of the pre-test probabilities may provide clarity on which patients with suspected giant cell arteritis would benefit from this invasive diagnostic procedure. DESIGN: A prospective case series PARTICIPANTS: A consecutive case series of patients referred to the Ophthalmology service for temporal artery biopsy. METHODS: All subjects underwent standardized serum testing, and signs and symptoms assessment...
December 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/29200816/multivariable-prediction-model-for-suspected-giant-cell-arteritis-development-and-validation
#20
Edsel B Ing, Gabriela Lahaie Luna, Andrew Toren, Royce Ing, John J Chen, Nitika Arora, Nurhan Torun, Otana A Jakpor, J Alexander Fraser, Felix J Tyndel, Arun Ne Sundaram, Xinyang Liu, Cindy Ty Lam, Vivek Patel, Ezekiel Weis, David Jordan, Steven Gilberg, Christian Pagnoux, Martin Ten Hove
Purpose: To develop and validate a diagnostic prediction model for patients with suspected giant cell arteritis (GCA). Methods: A retrospective review of records of consecutive adult patients undergoing temporal artery biopsy (TABx) for suspected GCA was conducted at seven university centers. The pathologic diagnosis was considered the final diagnosis. The predictor variables were age, gender, new onset headache, clinical temporal artery abnormality, jaw claudication, ischemic vision loss (VL), diplopia, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and platelet level...
2017: Clinical Ophthalmology
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