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Temporal arteritis

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https://www.readbyqxmd.com/read/29895392/radiographic-study-to-assess-the-reliability-of-the-gillies-approach-for-biopsy-of-the-superficial-temporal-artery
#1
D M Girgis, D J Gibson, C J Wood, S S Subramaniam, A M Bobinskas
Biopsy of the superficial temporal artery is often used in the diagnosis of giant cell arteritis, but at traditional sites there is a risk of injury to the facial nerve. Recently the Gillies incision has been suggested as an alternative means of access for the biopsy, but the anatomical basis of this has not been fully elucidated. We therefore undertook a radiographic review of 150 patients, and examining 300 vessels, to find out. Our results indicated that there is considerable variability in the position of the bifurcation of the superficial temporal artery, and so a Gillies approach may not be reliable, particularly if access to the bifurcation is required...
June 9, 2018: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/29890162/pathologic-markers-determining-prognosis-in-patients-with-treated-or-healing-giant-cell-arteritis
#2
Harris Sultan, Stacy V Smith, Andrew G Lee, Patricia Chévez-Barrios
PURPOSE: To provide quantitative evidence linking the Cluster of Differentiation-68 (CD68)+ macrophage-marker found on temporal artery biopsies (TABs) with disease prognosis. DESIGN: Retrospective, cross-sectional study METHODS: We examined 42 consecutive patients who had undergone unilateral TABs at a single hospital in 2015. Clinical data, laboratory data, and histopathologic features of TABs were recorded. INCLUSION CRITERIA: clinical diagnosis of giant cell arteritis (GCA) with TAB performed at the same center...
June 8, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29880442/arterial-lesions-in-giant-cell-arteritis-a-longitudinal-study
#3
Tanaz A Kermani, Sehriban Diab, Antoine G Sreih, David Cuthbertson, Renée Borchin, Simon Carette, Lindsy Forbess, Curry L Koening, Carol A McAlear, Paul A Monach, Larry Moreland, Christian Pagnoux, Philip Seo, Robert F Spiera, Kenneth J Warrington, Steven R Ytterberg, Carol A Langford, Peter A Merkel, Nader A Khalidi
OBJECTIVES: To evaluate large-vessel (LV) abnormalities on serial imaging in patients with giant cell arteritis (GCA) and discern predictors of new lesions. METHODS: Clinical and imaging data from patients with GCA (including subjects diagnosed by LV imaging) enrolled in a prospective, multicenter, longitudinal study and/or a randomized clinical trial were included. New arterial lesions were defined as a lesion in a previously unaffected artery. RESULTS: The study included 187 patients with GCA, 146 (78%) female, mean (±SD) age at diagnosis 68...
May 9, 2018: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29872033/co-presentation-of-giant-cell-arteritis-and-granulomatosis-with-polyangiitis-a-case-report-and-review-of-literature
#4
Haitham H Hassane, Mirza M Beg, Chokkalingam Siva, Celso Velázquez
BACKGROUND Systemic vasculitis can present with a multitude of symptoms involving multiple organ systems. Clinicians should avoid anchoring bias and be cognizant that different types of vasculitides can be present in the same patient and that the diagnosis of one should not preclude the subsequent diagnosis of another. CASE REPORT A 67-year-old woman was referred for evaluation of episodes of epistaxis and recurrent severe sinusitis. Her physical examination showed nasal congestion and purpuric rash on the lower extremities...
June 6, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29871775/doppler-ultrasonography-of-superficial-temporal-artery-in-a-cohort-of-patients-with-strong-clinical-suspicion-of-giant-cell-arteritis
#5
Paula Estrada Alarcón, Dèlia Reina, Vanessa Navarro Ángeles, Dacia Cerdà, Daniel Roig-Vilaseca, Hèctor Corominas
BACKGROUND AND OBJECTIVE: Giant cell arteritis (GCA) is the most frequent systemic vasculitis in adults. In recent years, the usefulness of temporal artery ultrasound (TAUS) as a diagnostic tool to assess the underlying inflammation of the vascular wall during the inflammatory process has been under clinical investigation. MATERIAL AND METHODS: Observational and descriptive cohort study of 120 TAUS in 60 patients with clinical suspicions of GCA, according to the ACR (American College of Rheumatology) classification criteria...
June 2, 2018: Medicina Clínica
https://www.readbyqxmd.com/read/29862043/definitions-and-reliability-assessment-of-elementary-ultrasound-lesions-in-giant-cell-arteritis-a-study-from-the-omeract-large-vessel-vasculitis-ultrasound-working-group
#6
Stavros Chrysidis, Christina Duftner, Christian Dejaco, Valentin S Schäfer, Sofia Ramiro, Greta Carrara, Carlo Alberto Scirè, Alojzija Hocevar, Andreas P Diamantopoulos, Annamaria Iagnocco, Chetan Mukhtyar, Cristina Ponte, Esperanza Naredo, Eugenio De Miguel, George A Bruyn, Kenneth J Warrington, Lene Terslev, Marcin Milchert, Maria Antonietta D'Agostino, Mattew J Koster, Naina Rastalsky, Petra Hanova, Pierluigi Macchioni, Tanaz A Kermani, Tove Lorenzen, Uffe Møller Døhn, Ulrich Fredberg, Wolfgang Hartung, Bhaskar Dasgupta, Wolfgang A Schmidt
Objectives: To define the elementary ultrasound (US) lesions in giant cell arteritis (GCA) and to evaluate the reliability of the assessment of US lesions according to these definitions in a web-based reliability exercise. Methods: Potential definitions of normal and abnormal US findings of temporal and extracranial large arteries were retrieved by a systematic literature review. As a subsequent step, a structured Delphi exercise was conducted involving an expert panel of the Outcome Measures in Rheumatology (OMERACT) US Large Vessel Vasculitis Group to agree definitions of normal US appearance and key elementary US lesions of vasculitis of temporal and extracranial large arteries...
2018: RMD Open
https://www.readbyqxmd.com/read/29790570/-%C3%A2-man-in-the-barrel%C3%A2-syndrome-atypical-manifestation-of-giant-cell-arteritis
#7
Y Calle-Lopez, A F Fernandez-Ramirez, E Franco-Dager, J G Gomez-Lopera, A L Vanegas-Garcia
INTRODUCTION: «Man-in-the-barrel» syndrome refers to diplegia of the upper extremities in which mobility of the head and lower limbs is preserved. Brachial plexitis that presents as «man-in-the-barrel» syndrome is an unusual manifestation of giant cell arteritis. We report a case of C5-C6 plexitis as part of the clinical features of a patient with giant cell arteritis. CASE REPORT: A 70-year-old male with a two-month history of weight loss, headache, facial pain and jaw claudication, associated with a persistent elevation of acute phase reactants and bilateral brachial plexopathy, with no evidence of neck or brain injuries or occult neoplasm and with negative autoimmunity tests...
June 1, 2018: Revista de Neurologia
https://www.readbyqxmd.com/read/29784156/lower-ocular-pulse-amplitude-with-dynamic-contour-tonometry-is-associated-with-biopsy-proven-giant-cell-arteritis
#8
Edsel Ing, Christian Pagnoux, Felix Tyndel, Arun Sundaram, Seymour Hershenfeld, Paul Ranalli, Shirley Chow, Tran Le, Carla Lutchman, Susan Rutherford, Kay Lam, Harleen Bedi, Nurhan Torun
OBJECTIVES: To determine the role of the ocular pulse amplitude (OPA) from Pascal dynamic contour tonometry in predicting the temporal artery biopsy (TABx) result in patients with suspected giant cell arteritis (GCA). DESIGN: Prospective validation study. PARTICIPANTS: Adults aged 50 years or older who underwent TABx from March 2015 to April 2017. METHODS: Subjects on high-dose glucocorticoids more than 14 days or without serology before glucocorticoid initiation were excluded...
June 2018: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/29772570/undertreatment-of-vascular-risk-factors-in-patients-with-monocular-ischaemic-visual-loss
#9
Angeliki Zarkali, Suk Fun Cheng, Agnes Dados, Robert Simister, Arvind Chandratheva
BACKGROUND AND PURPOSE: Ischaemic visual loss is often considered a lower risk factor than other transient ischaemic attacks (TIA). We aimed to determine the recurrence risk, prevalence and management of vascular risk factors in these patients. METHODS: The study took place in the University College Hospital London daily TIA clinic, main referral centre for North-Central London and Moorfields Eye Hospital. Consecutive records for patients with transient (< 24 h) or permanent (> 24 h) ischaemic visual loss were reviewed during the period January 2014-October 2016...
May 17, 2018: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/29761968/-computer-assisted-quantitative-analysis-of-contrast-enhanced-ultrasonography-in-takayasu-arteritis-carotid-artery-lesions
#10
Yanlu Hu, Qi Zhang, Chaolun Li
Takayasu arteritis (TA) is a chronic nonspecific inflammation that commonly occurs in the aorta and its main branches. Most patients with TA are lack of clinical manifestations, leading to misdiagnosis. When the TA is correctly diagnosed, the patients may already have stenosis or occlusion in the involved arteries, resulting in arterial ischemia and hypoxia symptoms, and in severe cases it will be life-threatening. Contrast-enhanced ultrasonography (CEUS) is an emerging method for assessing TA, but the assessment relies heavily on experiences of radiologists performing manual and qualitative analyses, so the diagnostic results are often not accurate...
October 1, 2017: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/29759126/primary-care-vasculitis-polymyalgia-rheumatica-and-giant-cell-arteritis
#11
REVIEW
Mathilde H Pioro
Polymyalgia rheumatica (PMR) and giant cell arteritis (GCA) are related inflammatory diseases of adults aged 50 years or older. The diagnosis of PMR is based on morning stiffness, proximal shoulder and pelvic girdle pain, and functional impairment. GCA is characterized by headache, jaw claudication, and visual disturbances. Constitutional symptoms and elevated inflammatory markers are common to both conditions. Temporal artery biopsy remains the gold standard for diagnosis of GCA. Glucocorticoids are the cornerstone of therapy, with tapering regimens individualized to the patient...
June 2018: Primary Care
https://www.readbyqxmd.com/read/29746000/pericarditis-among-giant-cell-arteritis-patients-from-myth-to-reality
#12
Shmuel Tiosano, Yehuda Adler, Shir Azrielant, Yarden Yavne, Omer Gendelman, Dana Ben-Ami Shor, Doron Comaneshter, Guy Shalom, Arnon D Cohen, Howard Amital
BACKGROUND: Giant cell arteritis (GCA) is an inflammatory disease of unknown etiology affecting adults age > 50 years. GCA (also known as temporal arteritis) is a vasculitis of large and medium-size vessels that involves the extracranial branches of the carotid artery. Common manifestations include constitutional symptoms, headache, jaw claudication, scalp tenderness, and vision loss. Cardiac involvement in GCA is considered to be as low as 5%, and < 30 cases of pericarditis among GCA patients have been reported in the literature...
May 10, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29731755/expression-and-function-of-il12-23-related-cytokine-subunits-p35-p40-and-p19-in-giant-cell-arteritis-lesions-contribution-of-p40-to-th1-and-th17-mediated-inflammatory-pathways
#13
Georgina Espígol-Frigolé, Ester Planas-Rigol, Ester Lozano, Marc Corbera-Bellalta, Nekane Terrades-García, Sergio Prieto-González, Ana García-Martínez, Jose Hernández-Rodríguez, Josep M Grau, Maria C Cid
Background: Giant-cell arteritis (GCA) is considered a T helper (Th)1- and Th17-mediated disease. Interleukin (IL)-12 is a heterodimeric cytokine (p35/p40) involved in Th1 differentiation. When combining with p19 subunit, p40 compose IL-23, a powerful pro-inflammatory cytokine that maintains Th17 response. Objectives: The aims of this study were to investigate p40, p35, and p19 subunit expression in GCA lesions and their combinations to conform different cytokines, to assess the effect of glucocorticoid treatment on subunit expression, and to explore functional roles of p40 by culturing temporal artery sections with a neutralizing anti-human IL-12/IL-23p40 antibody...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29697809/cd3-immunohistochemistry-is-helpful-in-the-diagnosis-of-giant-cell-arteritis
#14
Francesco Ciccia, Angelo Ferrante, Giuliana Guggino, Alberto Cavazza, Carlo Salvarani, Aroldo Rizzo
Objective: To evaluate whether CD3 staining performed routinely on temporal artery biopsy specimens might improve the sensitivity of temporal artery biopsy in patients with biopsy-negative GCA. Methods: Two hundred and seventy biopsies were considered for this study, stained with haematoxylin and eosin and with an anti-CD3 antibody. Results: The addition of CD3 staining modified the sensibility and the specificity of the histologic examination in 89...
April 25, 2018: Rheumatology
https://www.readbyqxmd.com/read/29680850/temporal-headache-and-jaw-claudication-may-be-the-key-for-the-diagnosis-of-giant-cell-arteritis
#15
B Peral-Cagigal, Á Pérez-Villar, L-M Redondo-González, C García-Sierra, M Morante-Silva, B Madrigal-Rubiales, A Verrier-Hernández
BACKGROUND: Temporal artery biopsy (TAB) is a surgical procedure with a low positive yield. The purpose of this study is to determine which variables are the most important in the giant cell arteritis (GCA) diagnosis. The objective of this evaluation is to improve the percentage of positive temporal artery biopsy and if possible, avoid the biopsy in some cases. MATERIAL AND METHODS: A retrospective clinical study consisted of 90 patients who had undergone TAB at the Río Hortega Hospital (Spain) from January 2009 to December 2016...
May 1, 2018: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29611005/recent-advances-in-giant-cell-arteritis
#16
REVIEW
M Guevara, C S Kollipara
PURPOSE OF REVIEW: Giant cell arteritis (GCA) is the most common systemic vasculitis. GCA is categorized as a granulomatous vasculitis of large and medium size vessels. Majority of the symptoms and signs of GCA result from involvement of the aorta and its branches intra- and extracranial. Temporal artery biopsy continues to be the cardinal diagnostic procedure despite new imaging modalities for diagnosing GCA with cranial involvement. Great advances in awareness have led to improvement in preventing irreversible vision loss due to early diagnosis...
April 2, 2018: Current Rheumatology Reports
https://www.readbyqxmd.com/read/29600479/ct-analysis-of-the-aorta-in-giant-cell-arteritis-a-case-control-study
#17
Pierre Emmanuel Berthod, Serge Aho-Glélé, Paul Ornetti, Olivier Chevallier, Hervé Devilliers, Frédéric Ricolfi, Bernard Bonnotte, Romaric Loffroy, Maxime Samson
OBJECTIVES: Giant cell arteritis (GCA) is a large-vessel vasculitis whose diagnosis is confirmed by temporal artery biopsy. However, involvement of large vessels, especially the aorta, can be shown by imaging, which plays an increasing role in GCA diagnosis. The threshold above which aortic wall thickening, as measured by computed tomography (CT), is considered pathological is controversial, with values ranging from 2 to 3 mm. This study assessed aortic morphology by CT scan and its diagnostic value in GCA...
March 29, 2018: European Radiology
https://www.readbyqxmd.com/read/29549493/negative-temporal-artery-biopsy-predictive-factors-for-giant-cell-arteritis-diagnosis-and-alternate-diagnoses-of-patients-without-arteritis
#18
Gil Bornstein, Iris Barshack, Nira Koren-Morag, Ilan Ben-Zvi, Nadav Furie, Chagai Grossman
To investigate whether among patients with a negative temporal artery biopsy (TAB) there are clinical features that may differentiate between patients with an eventual diagnosis of giant cell arteritis (GCA) and those without arteritis, and to assess the eventual diagnoses of patients without arteritis. Retrospective analysis of patients with a negative TAB performed between 1/1/2000 and 31/12/2015. Information collected included baseline clinical and laboratory data. Patients' final diagnoses were obtained from medical records...
March 17, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29535121/response-to-the-role-of-temporal-artery-biopsy-in-patients-with-giant-cell-arteritis-is-debated-by-moiseev-et-al
#19
Christian Dejaco, Sofia Ramiro, Christina Duftner, Wolfgang A Schmidt
No abstract text is available yet for this article.
March 13, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29531788/imaging-in-diagnosis-outcome-prediction-and-monitoring-of-large-vessel-vasculitis-a-systematic-literature-review-and-meta-analysis-informing-the-eular-recommendations
#20
Christina Duftner, Christian Dejaco, Alexandre Sepriano, Louise Falzon, Wolfgang Andreas Schmidt, Sofia Ramiro
Objectives: To perform a systematic literature review on imaging techniques for diagnosis, outcome prediction and disease monitoring in large vessel vasculitis (LVV) informing the European League Against Rheumatism recommendations for imaging in LVV. Methods: Systematic literature review (until 10 March 2017) of diagnostic and prognostic studies enrolling >20 patients and investigating ultrasound, MRI, CT or positron emission tomography (PET) in patients with suspected and/or established primary LVV...
2018: RMD Open
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