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https://www.readbyqxmd.com/read/29346794/clinicoepidemiologic-features-of-chronic-urticaria-in-patients-with-versus-without-subclinical-helicobacter-pylori-infection-a-cross-sectional-study-of-150-patients
#1
Sakshi Kohli, Vikram K Mahajan, Baldev S Rana, Karaninder S Mehta, Rashmi Kaul Raina, Pushpinder S Chauhan, Vikas Sharma, Ritu Rawat
BACKGROUND: The Helicobacter pylori infection is linked to chronic urticaria in nearly 60% of patients. We studied clinicoepidemiologic features in patients with chronic urticaria with and without H. pylori infection. METHODS: Endoscopic antral biopsy for the rapid urease test (RUT) and histopathology, and serum IgG ELISA for H. pylori infection were performed in 150 patients (male:female ratio 1:2.4) of chronic urticaria aged 18-68 years. Clinicoepidemiologic features including age, gender, age of onset and duration, frequency and distribution of wheals, urticaria severity score, and systemic symptoms were analyzed in patients with and without H...
January 19, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29346769/switching-on-depression-and-potentiation-in-the-cerebellum
#2
Andrew R Gallimore, Taegon Kim, Keiko Tanaka-Yamamoto, Erik De Schutter
Long-term depression (LTD) and long-term potentiation (LTP) in the cerebellum are important for motor learning. However, the signaling mechanisms controlling whether LTD or LTP is induced in response to synaptic stimulation remain obscure. Using a unified model of LTD and LTP at the cerebellar parallel fiber-Purkinje cell (PF-PC) synapse, we delineate the coordinated pre- and postsynaptic signaling that determines the direction of plasticity. We show that LTP is the default response to PF stimulation above a well-defined frequency threshold...
January 16, 2018: Cell Reports
https://www.readbyqxmd.com/read/29346606/characteristics-of-cases-with-repeated-sexually-transmitted-infections-massachusetts-2014-2016
#3
Katherine K Hsu, Lauren E Molotnikov, Kathleen A Roosevelt, Heather R Elder, R Monina Klevens, Alfred DeMaria, Sevgi O Aral
Background: Persons with prior sexually transmitted infections (STIs) are at high risk for re-infection. No recent studies have examined the frequency with which persons within a geographic area are diagnosed and reported with multiple bacterial STIs over time. Methods: We conducted a retrospective, population-based study of confirmed syphilis, gonorrhea, and chlamydial infections reported to the Massachusetts state surveillance system within a two-year period, July 28, 2014 - July 27, 2016...
January 13, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29346604/unique-genetic-profiles-from-cerebrospinal-fluid-cell-free-dna-in-leptomeningeal-metastases-of-egfr-mutant-non-small-cell-lung-cancer-a-new-medium-of-liquid-biopsy
#4
Y S Li, B Y Jiang, J J Yang, X C Zhang, Z Zhang, J Y Ye, W Z Zhong, H Y Tu, H J Chen, Z Wang, C R Xu, B C Wang, H J Du, S Chuai, H Han-Zhang, J Su, Q Zhou, X N Yang, W B Guo, H H Yan, Y H Liu, L X Yan, B Huang, M M Zheng, Y L Wu
Background: Leptomeningeal metastases (LM) are more frequent in non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutations. Due to limited access to leptomeningeal lesions, the purpose of this study was to explore the potential role of cerebrospinal fluid (CSF) as a source of liquid biopsy in patients with LM. Patients and methods: Primary tumor, CSF, and plasma in NSCLC with LM were tested by next-generation sequencing. In total, 45 patients with suspected LM underwent lumbar puncture, and those with EGFR mutations diagnosed with LM were enrolled...
January 15, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29346588/genome-sequencing-of-museum-specimens-reveals-rapid-changes-in-the-genetic-composition-of-honey-bees-in-california
#5
Julie M Cridland, Santiago R Ramirez, Cheryl A Dean, Amber Sciligo, Neil D Tsutsui
The western honey bee, Apis mellifera, is an enormously influential pollinator in both natural and managed ecosystems. In North America, this species has been introduced numerous times from a variety of different source populations in Europe and Africa. Since then, feral populations have expanded into many different environments across their broad introduced range. Here, we used whole genome sequencing of historical museum specimens and newly collected modern populations from California (USA) to analyze the impact of demography and selection on introduced populations during the past 105 years...
January 15, 2018: Genome Biology and Evolution
https://www.readbyqxmd.com/read/29346583/datamed-an-open-source-discovery-index-for-finding-biomedical-datasets
#6
Xiaoling Chen, Anupama E Gururaj, Burak Ozyurt, Ruiling Liu, Ergin Soysal, Trevor Cohen, Firat Tiryaki, Yueling Li, Nansu Zong, Min Jiang, Deevakar Rogith, Mandana Salimi, Hyeon-Eui Kim, Philippe Rocca-Serra, Alejandra Gonzalez-Beltran, Claudiu Farcas, Todd Johnson, Ron Margolis, George Alter, Susanna-Assunta Sansone, Ian M Fore, Lucila Ohno-Machado, Jeffrey S Grethe, Hua Xu
Objective: Finding relevant datasets is important for promoting data reuse in the biomedical domain, but it is challenging given the volume and complexity of biomedical data. Here we describe the development of an open source biomedical data discovery system called DataMed, with the goal of promoting the building of additional data indexes in the biomedical domain. Materials and Methods: DataMed, which can efficiently index and search diverse types of biomedical datasets across repositories, is developed through the National Institutes of Health-funded biomedical and healthCAre Data Discovery Index Ecosystem (bioCADDIE) consortium...
January 13, 2018: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29346573/the-addition-of-bevacizumab-to-oxaliplatin-based-chemotherapy-impact-upon-hepatic-sinusoidal-injury-and-thrombocytopenia
#7
Michael J Overman, Renata Ferrarotto, Kanwal Raghav, Binsah George, Wei Qiao, Karime K Machado, Leonard B Saltz, Thibault Mazard, J N Vauthey, Paulo M Hoff, Brian Hobbs, Evelyn M Loyer, Scott Kopetz
Background: Oxaliplatin-based chemotherapy can cause hepatic sinusoidal injury (HSI), portal hypertension, and splenic sequestration of platelets. Evidence suggests that bevacizumab may protect against HSI. Methods: Two cohorts of metastatic colorectal cancer (CRC) were analyzed: a nonrandomized exploratory cohort of 184 patients treated at a single institution from 2003 to 2010 and a confirmatory cohort of 200 patients from a multi-institutional randomized trial (NO16966)...
January 15, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29346525/frailty-syndrome-and-genomic-instability-in-older-adults-suitability-of-the-cytome-micronucleus-assay-as-a-diagnostic-tool
#8
María Sánchez-Flores, Diego Marcos-Pérez, Laura Lorenzo-López, Ana Maseda, José C Millán-Calenti, Stefano Bonassi, Eduardo Pásaro, Blanca Laffon, Vanessa Valdiglesias
Frailty, a condition involving increased risk of disability and mortality in older adults, has emerged as a reliable way to predict the effect of aging. Genomic instability may help to anticipate recognition of frail individuals and improving frailty outcomes. Our objective was to evaluate the potential of the micronucleus (MN) frequency, evaluated in lymphocytes and buccal cells, to anticipate frailty identification and improve diagnosis reliability. Our results, from a group of older adults over 65, showed that frail individuals had significantly higher frequencies of MN in lymphocytes (19...
January 13, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29346484/association-of-dietary-inflammatory-potential-with-colorectal-cancer-risk-in-men-and-women
#9
Fred K Tabung, Li Liu, Weike Wang, Teresa T Fung, Kana Wu, Stephanie A Smith-Warner, Yin Cao, Frank B Hu, Shuji Ogino, Charles S Fuchs, Edward L Giovannucci
Importance: Inflammation is important in colorectal cancer development. Diet modulates inflammation and may thus be a crucial modifiable factor in colorectal cancer prevention. Objective: To examine whether proinflammatory diets are associated with increased colorectal cancer risk by using an empirical dietary inflammatory pattern (EDIP) score based on a weighted sum of 18 food groups that characterizes dietary inflammatory potential based on circulating levels of inflammation biomarkers...
January 18, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29346475/current-status-of-radiology-training-in-otolaryngology-residency-programs
#10
Kirkland N Lozada, Joseph M Bernstein
Importance: Otolaryngologists use head and neck imaging on a daily basis. However, little is known about the training residents receive on the subject. Understanding the current training environment is important to identify areas of improvement for resident education. Objective: To assess the current state of radiology training in otolaryngology residency programs. Design, Setting, and Participants: This was a cross-sectional survey of 106 otolaryngology residency program directors involving multiple academic institutions...
January 18, 2018: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29346381/control-of-recollection-by-slow-gamma-dominating-mid-frequency-gamma-in-hippocampus-ca1
#11
Dino Dvorak, Basma Radwan, Fraser T Sparks, Zoe Nicole Talbot, André A Fenton
Behavior is used to assess memory and cognitive deficits in animals like Fmr1-null mice that model Fragile X Syndrome, but behavior is a proxy for unknown neural events that define cognitive variables like recollection. We identified an electrophysiological signature of recollection in mouse dorsal Cornu Ammonis 1 (CA1) hippocampus. During a shocked-place avoidance task, slow gamma (SG) (30-50 Hz) dominates mid-frequency gamma (MG) (70-90 Hz) oscillations 2-3 s before successful avoidance, but not failures...
January 18, 2018: PLoS Biology
https://www.readbyqxmd.com/read/29346345/the-cytosolic-sensor-sting-is-required-for-intestinal-homeostasis-and-control-of-inflammation
#12
M C C Canesso, L Lemos, T C Neves, F M Marim, T B R Castro, É S Veloso, C P Queiroz, J Ahn, H C Santiago, F S Martins, J Alves-Silva, E Ferreira, D C Cara, A T Vieira, G N Barber, S C Oliveira, A M C Faria
STING (stimulator of interferon genes) is a cytosolic sensor for cyclic dinucleotides and also an adaptor molecule for intracellular DNA receptors. Although STING has important functions in the host defense against pathogens and in autoimmune diseases, its physiological relevance in intestinal homeostasis is largely unknown. In this study, we show that STING-/- mice presented defective protective mechanisms of intestinal mucosa, including decreased number of goblet cells, diminished mucus production, and lower levels of secretory IgA, when compared with wild-type (WT) mice...
December 20, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/29346298/motion-tracking-system-for-robust-non-contact-blood-perfusion-sensor
#13
Masaaki Hashimoto, Yoshihiro Taguchi
We propose a motion-robust laser Doppler flowmetry (LDF) system that can be used as a non-contact blood perfusion sensor for medical diagnosis. Endoscopic LDF systems are typically limited in their usefulness in clinical contexts by the need for the natural organs to be immobilized, as serious motion artifacts due to the axial surface displacement can interfere with blood perfusion measurements. In our system, the focusing lens moves to track the motion of the target using a low-frequency reference signal in the optical data, enabling the suppression of these motion artifacts in the axial direction...
January 18, 2018: Sensors
https://www.readbyqxmd.com/read/29346297/the-dynamic-performance-of-flexural-ultrasonic-transducers
#14
Andrew Feeney, Lei Kang, George Rowlands, Steve Dixon
Flexural ultrasonic transducers are principally used as proximity sensors and for industrial metrology. Their operation relies on a piezoelectric ceramic to generate a flexing of a metallic membrane, which delivers the ultrasound signal. The performance of flexural ultrasonic transducers has been largely limited to excitation through a short voltage burst signal at a designated mechanical resonance frequency. However, a steady-state amplitude response is not generated instantaneously in a flexural ultrasonic transducer from a drive excitation signal, and differences in the drive characteristics between transmitting and receiving transducers can affect the measured response...
January 18, 2018: Sensors
https://www.readbyqxmd.com/read/29346282/smartphone-based-cooperative-indoor-localization-with-rfid-technology
#15
Fernando Seco, Antonio R Jiménez
In GPS-denied indoor environments, localization and tracking of people can be achieved with a mobile device such as a smartphone by processing the received signal strength (RSS) of RF signals emitted from known location beacons (anchor nodes), combined with Pedestrian Dead Reckoning (PDR) estimates of the user motion. An enhacement of this localization technique is feasible if the users themselves carry additional RF emitters (mobile nodes), and the cooperative position estimates of a group of persons incorporate the RSS measurements exchanged between users...
January 18, 2018: Sensors
https://www.readbyqxmd.com/read/29346280/a-multi-band-body-worn-distributed-radio-frequency-exposure-meter-design-on-body-calibration-and-study-of-body-morphology
#16
Reza Aminzadeh, Arno Thielens, Sam Agneessens, Patrick Van Torre, Matthias Van den Bossche, Stefan Dongus, Marloes Eeftens, Anke Huss, Roel Vermeulen, René de Seze, Paul Mazet, Elisabeth Cardis, Hendrik Rogier, Martin Röösli, Luc Martens, Wout Joseph
A multi-band Body-Worn Distributed exposure Meter (BWDM) calibrated for simultaneous measurement of the incident power density in 11 telecommunication frequency bands, is proposed. The BDWM consists of 22 textile antennas integrated in a garment and is calibrated on six human subjects in an anechoic chamber to assess its measurement uncertainty in terms of 68% confidence interval of the on-body antenna aperture. It is shown that by using multiple antennas in each frequency band, the uncertainty of the BWDM is 22 dB improved with respect to single nodes on the front and back of the torso and variations are decreased to maximum 8...
January 18, 2018: Sensors
https://www.readbyqxmd.com/read/29346187/quality-in-postoperative-patient-handover-different-perceptions-of-quality-between-transferring-and-receiving-nurses
#17
Elizabeth Reine, Johan Ræder, Tanja Manser, Milada C Småstuen, Tone Rustøen
This cross-sectional study assessed how nurses transferring and receiving patients in the postoperative care unit evaluate quality in patient handovers. Analysis of 192 questionnaires showed that transferring nurses had more positive evaluations of handover quality compared with the receiving nurses. Handovers evaluated as having lower quality had a higher frequency of time pressure, uncertainty, and clinical problems. The findings in the study point at a need to assess handover quality in a wider perspective...
January 16, 2018: Journal of Nursing Care Quality
https://www.readbyqxmd.com/read/29346145/diagnostic-and-therapeutic-ultrasound-on-venous-and-arterial-ulcers-a-focused-review
#18
Steven J Kavros, Robert Coronado
GENERAL PURPOSE: To provide information about the use of ultrasound for diagnostic and therapeutic treatment of venous and arterial ulcers. TARGET AUDIENCE: This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care. LEARNING OBJECTIVES/OUTCOMES: After completing this continuing education activity, you should be able to: ABSTRACT: To review the diagnostic and therapeutic use of ultrasound on venous and arterial ulcers...
February 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29346140/neonatal-hypoglycemia-continuous-glucose-monitoring
#19
Rajesh Shah, Christopher J D McKinlay, Jane E Harding
PURPOSE OF REVIEW: Continuous glucose monitoring (CGM) is increasingly used in the management of diabetes in children and adults, but there are few data regarding its use in neonates. The purpose of this article is to discuss the potential benefits and limitations of CGM in neonates. RECENT FINDINGS: Smaller electrodes in new sensors and real-time monitoring have made CGM devices more approachable for neonatal care. CGM is well tolerated in infants including very low birth weight babies, and few if any local complications have been reported...
January 17, 2018: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/29346105/automated-detection-of-postictal-generalized-eeg-suppression
#20
Wanchat Theeranaew, James McDonald, Bilal Zonjy, Farhad Kaffashi, Brian D Moseley, Daniel Friedman, Elson So, James Tao, Maromi Nei, Philippe Ryvlin, Rainer Surges, Roland Thijs, Stephan Schuele, Samden Lhatoo, Kenneth A Loparo
Although there is no strict consensus, some studies have reported that Postictal generalized EEG suppression (PGES) is a potential electroencephalographic (EEG) biomarker for risk of sudden unexpected death in epilepsy (SUDEP). PGES is an epoch of EEG inactivity after a seizure, and the detection of PGES in clinical data is extremely difficult due to artifacts from breathing, movement and muscle activity that can adversely affect the quality of the recorded EEG data. Even clinical experts visually interpreting the EEG will have diverse opinions on the start and end of PGES for a given patient...
February 2018: IEEE Transactions on Bio-medical Engineering
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