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https://www.readbyqxmd.com/read/27933711/using-a-co-production-prioritization-exercise-involving-south-asian-children-young-people-and-their-families-to-identify-health-priorities-requiring-further-research-and-public-awareness
#1
Logan Manikam, Rakhee Shah, Kate Reed, Gupreet Santini, Monica Lakhanpaul
OBJECTIVES: To facilitate South Asian (SA) families and health-care professionals (HCPs) participation in a prioritization exercise to co-produce child health research and public awareness agendas. DESIGN: A three-stage process was adopted involving the following: (i) systematic literature review, (ii) HCP scoping survey and (iii) focus groups of SA adolescents and families. A Punjabi- and Urdu-speaking community facilitator moderated focus groups. A British Sign Language interpreter assisted in the hard of hearing group...
December 8, 2016: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/27933672/single-neuron-activity-and-theta-modulation-in-the-posterior-parietal-cortex-in-a-visuospatial-attention-task
#2
Fang-Chi Yang, T K Jacobson, R D Burwell
The posterior parietal cortex (PPC) is implicated in directing and maintaining visual attention to locations in space. We hypothesized that the PPC also engages other cognitive processes in the transformation of behaviorally relevant visual inputs into appropriate actions, for example, monitoring of multiple locations, selection of responses to locations in space, and monitoring the outcome of response selections. We recorded single cells and local field potentials in the rat PPC during performance on a novel visuospatial attention (VSA) task that requires visually monitoring locations in space in order to make appropriate stimulus-guided locomotor responses...
December 9, 2016: Hippocampus
https://www.readbyqxmd.com/read/27933666/risk-of-stroke-and-recurrence-after-af-ablation-in-patients-with-an-initial-event-free-period-of-12-months
#3
Simon Kochhäuser, Pouria Alipour, Tanjah Haig-Carter, Kathleen Trought, Philip Hache, Yaariv Khaykin, Zaev Wulffhart, Alfredo Pantanomd, Bernice Tsang, David Birnie, Atul Verma
INTRODUCTION: Because of the unclear prognostic effects of ablation of atrial fibrillation (AF), oral anticoagulation (OAC) is often continued after ablation even in asymptomatic patients. We sought to determine the frequency of stroke and AF recurrence in patients on and off therapeutic OAC one year after a successful AF ablation. METHODS AND RESULTS: Patients that underwent AF ablation and were free of AF 12 months after ablation were selected from our AF database...
December 9, 2016: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/27933646/antisperm-antibodies-in-repeat-breeding-cows-frequency-detection-and-validation-of-threshold-levels-employing-sperm-immobilization-sperm-agglutination-and-immunoperoxidase-assay
#4
S K Srivastava, S Shinde, S K Singh, S Mehrotra, M R Verma, A K Singh, S Nandi, N Srivastava, S K Singh, T K Goswami, S K Bhure, H Kumar, S K Ghosh
Antisperm antibodies have been found in repeat-breeding(RB) cows, and those causing agglutination and/or immobilization of sperm are considered to be closely related to unexplained infertility. However, a standard protocol for identifying antisperm antibodies (ASA) in cattle is not validated. Therefore, an investigation was undertaken to evaluate sperm immobilization (SIT), sperm agglutination (SAT) and immunoperoxidase (IPT)assays for detection of ASA in serum and their respective threshold levels for confirmation...
December 8, 2016: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/27933645/aflatoxin-biomarkers-in-hair-may-facilitate-long-term-exposure-studies
#5
Innocent Mupunga, Christo D Izaaks, Leshweni J Shai, David R Katerere
Aflatoxins are highly toxic fungal metabolites produced by some members of the Aspergillus species. They are low molecular weight lipophilic compounds that are easily absorbed from the gastrointestinal tract. They contaminate most staple foods, including maize, peanuts, peanut butter and sorghum mainly in the tropics where hot and humid conditions promote fungal growth. Absorbed aflatoxins are metabolized by the cytochrome P450 enzyme system in the liver into toxic metabolites. Aflatoxin B (AFB)1 is the most toxic, carcinogenic and mutagenic naturally occurring toxin...
December 9, 2016: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/27933615/immediate-release-versus-controlled-release-carbamazepine-in-the-treatment-of-epilepsy
#6
REVIEW
Graham Powell, Matthew Saunders, Alexandra Rigby, Anthony G Marson
BACKGROUND: Carbamazepine (CBZ) is a commonly used drug for epilepsy that is associated with troublesome adverse events including dizziness, double vision, drowsiness, poor co-ordination and unsteadiness. These adverse events often occur during peaks in drug plasma concentration. These adverse events may limit the daily dose of CBZ that can be tolerated and reduce the chances of seizure control in patients who require high doses. A controlled-release formulation of CBZ delivers the same dose over a longer period of time when compared to a standard immediate-release formulation, thereby reducing post-dose peaks in CBZ plasma concentration and potentially reducing adverse events...
December 8, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27933572/relation-between-the-stability-of-dental-implants-and-two-biological-markers-during-the-healing-period-a-prospective-clinical-study
#7
Choknapa Tirachaimongkol, Peraphan Pothacharoen, Peter A Reichart, Pathawee Khongkhunthian
OBJECTIVES: The purposes of this study were to examine the correlation between the stability of dental implants and bone formation markers during the healing period and to monitor the stability of dental implants using the resonance frequency analysis (RFA) method. The null hypothesis of the study is no correlation between the stability of dental implant and bone formation markers. METHODS: The study is a prospective clinical study during the 3-month healing period of implant...
December 2016: International Journal of Implant Dentistry
https://www.readbyqxmd.com/read/27933553/spontaneous-honeybee-behaviour-is-altered-by-persistent-organic-pollutants
#8
Jade Drummond, Sally M Williamson, Ann E Fitchett, Geraldine A Wright, Sarah J Judge
The effect of environmental pollutants on honeybee behaviour has focused mainly on currently used pesticides. However, honeybees are also exposed to persistent organic pollutants (POPs). The aim of this laboratory based study was to determine if exposure to sublethal field-relevant concentrations of POPs altered the spontaneous behaviour of foraging-age worker honeybees. Honeybees (Apis mellifera) were orally exposed to either a sublethal concentration of the polychlorinated biphenyl (PCB) mixture Aroclor 1254 (100 ng/ml), the organochlorine insecticide lindane (2...
December 8, 2016: Ecotoxicology
https://www.readbyqxmd.com/read/27933487/evaluation-of-standardized-triple-intrathecal-therapy-toxicity-in-oncohematological-pediatric-patients
#9
Raquel Olmos-Jiménez, María Sacramento Díaz-Carrasco, Ana Galera-Miñarro, Juan Francisco Pascual-Gazquez, Alberto Espuny-Miró
Background The administration of triple intrathecal therapy with methotrexate, cytarabine and a corticosteroid for the prophylaxis and treatment of neoplastic cell infiltration in the central nervous system in hematological malignancies is a widespread practice. There is limited information available about its toxicity profile. Several factors related to intrathecal preparation can affect toxicity. Thus, it was decided to standardize intrathecal chemotherapy, trying to obtain the best toxicity profile. Objective To assess the toxicity of a standardized triple intrathecal chemotherapy in oncohematological pediatric patients and to establish risk factors of toxicity...
December 8, 2016: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/27933442/arterial-pulse-wave-propagation-velocity-in-healthy-dogs-by-pulse-wave-doppler-ultrasound
#10
Rodrigo B Nogueira, Lucas A Pereira, Alice F Basso, Ingrid S da Fonseca, Lorena A Alves
The aim of this study was to prospectively evaluate the carotid-femoral pulse wave velocity (PWV) values in healthy dogs using pulse wave Doppler ultrasound. A secondary aim was to determine the feasibility of this method and to report the intra- and interobserver reproducibilities of the PWV in conscious dogs. The data were studied in 30 healthy, adult, male (n = 15) and female (n = 15) dogs. The time interval marked between the R wave peak of the electrocardiogram and the intersection of the blood flow wave upstroke of the Doppler spectrum with the baseline of zero frequency was determined for the carotid (T1) and for the femoral (T2) arteries...
December 8, 2016: Veterinary Research Communications
https://www.readbyqxmd.com/read/27933412/genetic-diversity-study-on-12-x-str-loci-of-investigator%C3%A2-argus-x-str-kit-in-bangladeshi-population
#11
Abu Sufian, Md Ismail Hosen, Kaniz Fatema, Tania Hossain, Md Mahamud Hasan, Ashish Kumar Mazumder, Sharif Akhteruzzaman
The X-chromosome short tandem repeat (STR) loci are of particular interest for solving complex kinship and paternity cases. Here, we report the genetic data from 209 unrelated Bangladeshi individuals (102 males and 107 females) that were genotyped using the 12 X-chromosomal STR markers included in the Investigator® Argus X-12 kit (Qiagen). The 12 X-STR markers are located in four linkage groups (linkage group I: DXS10135, DXS10148, and DXS8378; linkage group II: DXS7132, DXS10079, and DXS10074; linkage group III: DXS10103, HPRTB, and DXS10101; and linkage group IV: DXS10146, DXS10134, and DXS7423)...
December 8, 2016: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/27933349/-speech-audiometric-outcome-parameters-in-clinical-trials-on-hearing-improvement
#12
J Müller, S K Plontke, T Rahne
BACKGROUND: When comparing clinical studies nationally and internationally, there is great heterogeneity in the applied audiometric outcome parameters. Beside different frequencies included in pure-tone audiometry and the resulting averages, the word recognition scores are measured at varying sound pressure levels, i.e., either with a fixed sound pressure level or with a fixed sensation level. However, a comparison of studies, e. g., in meta-analysis, requires comparable outcome parameters...
December 8, 2016: HNO
https://www.readbyqxmd.com/read/27933341/intragenic-variations-in-btla-gene-influence-mrna-expression-of-btla-gene-in-chronic-lymphocytic-leukemia-patients-and-confer-susceptibility-to-chronic-lymphocytic-leukemia
#13
Lidia Karabon, Anna Partyka, Monika Jasek, Ewa Lech-Maranda, Olga Grzybowska-Izydorczyk, Agnieszka Bojarska-Junak, Edyta Pawlak-Adamska, Anna Tomkiewicz, Tadeusz Robak, Jacek Rolinski, Irena Frydecka
The aim of this study was to determine the association between polymorphisms in gene encoding B- and T-lymphocyte attenuator (BTLA) and susceptibility to chronic lymphocytic leukemia (CLL) and their influence on mRNA expression of BTLA gene in T and B cells from CLL patients (pts.). The following BTLA single-nucleotide polymorphisms (SNPs): rs2705511, rs1982809, rs9288952, rs76844316, rs16859633, rs9288953, rs2705535, rs1844089, rs2705565, rs2633580 were genotyped with use of TaqMan probes in 321 CLL pts. and in 470 controls...
December 8, 2016: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/27933325/influence-of-pre-etching-times-on-fatigue-strength-of-self-etch-adhesives-to-enamel
#14
Toshiki Takamizawa, Wayne W Barkmeier, Akimasa Tsujimoto, Hajime Endo, Kenji Tsuchiya, Robert L Erickson, Mark A Latta, Masashi Miyazaki
PURPOSE: To use shear bond strength (SBS) and shear fatigue strength (SFS) testing to determine the influence of phosphoric acid pre-etching times prior to application of self-etch adhesives on enamel bonding. MATERIALS AND METHODS: Two single-step self-etch universal adhesives (Prime&Bond Elect and Scotchbond Universal), a conventional single-step self-etch adhesive (G-ӕnial Bond), and a conventional two-step self-etch adhesive (OptiBond XTR) were used. The SBS and SFS were obtained with phosphoric acid pre-etching for 3, 10, or 15 s prior to application of the adhesives, and without pre-etching (0 s) as a control...
December 8, 2016: Journal of Adhesive Dentistry
https://www.readbyqxmd.com/read/27933285/developmental-profile-and-diagnoses-in-children-presenting-with-motor-stereotypies
#15
Francesco Cardona, Francesca Valente, Daniela Miraglia, Caterina D'Ardia, Valentina Baglioni, Flavia Chiarotti
INTRODUCTION: Motor stereotypies represent a typical example of the difficulty in distinguishing non-clinical behaviors (physiological and transient) from symptoms or among different disorders ["primary stereotypies," associated with autistic spectrum disorder (ASD), intellectual disabilities, genetic syndromes, and sensory impairment]. The aim of this study was to obtain an accurate assessment on the relationship between stereotypies and neurodevelopmental disorders. METHODS: We studied 23 children (3 girls), aged 36-95 months, who requested a consultation due to the persistence or increased severity of motor stereotypies...
2016: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/27933206/improving-inflammatory-arthritis-management-through-tighter-monitoring-of-patients-and-the-use-of-innovative-electronic-tools
#16
REVIEW
Piet van Riel, Rieke Alten, Bernard Combe, Diana Abdulganieva, Paola Bousquet, Molly Courtenay, Cinzia Curiale, Antonio Gómez-Centeno, Glenn Haugeberg, Burkhard Leeb, Kari Puolakka, Angelo Ravelli, Bernhard Rintelen, Piercarlo Sarzi-Puttini
Treating to target by monitoring disease activity and adjusting therapy to attain remission or low disease activity has been shown to lead to improved outcomes in chronic rheumatic diseases such as rheumatoid arthritis and spondyloarthritis. Patient-reported outcomes, used in conjunction with clinical measures, add an important perspective of disease activity as perceived by the patient. Several validated PROs are available for inflammatory arthritis, and advances in electronic patient monitoring tools are helping patients with chronic diseases to self-monitor and assess their symptoms and health...
2016: RMD Open
https://www.readbyqxmd.com/read/27933184/coxsackie-adenovirus-receptor-expression-is-enhanced-in-pancreas-from-patients-with-type-1-diabetes
#17
M Hodik, M Anagandula, J Fuxe, L Krogvold, K Dahl-Jørgensen, H Hyöty, L Sarmiento, G Frisk
OBJECTIVES: One of the theories connecting enterovirus (EV) infection of human islets with type 1 diabetes (T1D) is the development of a fertile field in the islets. This implies induction of appropriate proteins for the viral replication such as the coxsackie-adenovirus receptor (CAR). The aim of this study was to investigate to what extent CAR is expressed in human islets of Langerhans, and what conditions that would change the expression. DESIGN: Immunohistochemistry for CAR was performed on paraffin-embedded pancreatic tissue from patients with T1D (n=9 recent onset T1D, n=4 long-standing T1D), islet autoantibody-positive individuals (n=14) and non-diabetic controls (n=24) individuals...
2016: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/27933120/fast-and-selective-cell-isolation-from-blood-sample-by-microfiber-fabric-system-with-vacuum-aspiration
#18
Takayuki Ueki, Akifumi Yoshihara, Yuji Teramura, Madoka Takai
Since circulating tumor cells (CTCs) are tumor cells which are found in the blood of cancer patients, CTCs are potential tumor markers, so a rapid isolation of CTCs is desirable for clinical applications. In this paper, a three-dimensional polystyrene (PS) microfiber fabric with vacuum aspiration system was developed for capturing CTCs within a short time. Various microfiber fabrics with different diameters were prepared by the electrospinning method and optimized for contact frequency with cells. Vacuum aspiration utilizing these microfiber fabrics could filter all cells within seconds without mechanical damage...
2016: Science and Technology of Advanced Materials
https://www.readbyqxmd.com/read/27933119/longitudinal-conductivity-of-laf3-srf2-multilayer-heterostructures
#19
Tikhon Vergentev, Alexander Banshchikov, Alexey Filimonov, Ekaterina Koroleva, Nikolay Sokolov, Marc Christopher Wurz
LaF3/SrF2 multilayer heterostructures with thicknesses of individual layers in the range 5-100 nm have been grown on MgO(100) substrates using molecular beam epitaxy. The longitudinal conductivity of the films has been measured using impedance spectroscopy in the frequency range 10(-1)-10(6) Hz and a temperature range 300-570 K. The ionic DC conductivities have been determined from Nyquist impedance diagrams and activation energies from the Arrhenius-Frenkel equation. An increase of the DC conductivity has been observed to accompany decreased layer thickness for various thicknesses as small as 25 nm...
2016: Science and Technology of Advanced Materials
https://www.readbyqxmd.com/read/27933091/spatially-heterogeneous-environmental-selection-strengthens-evolution-of-reproductively-isolated-populations-in-a-dobzhansky-muller-system-of-hybrid-incompatibility
#20
Samuel A Cushman, Erin L Landguth
Within-species hybrid incompatibility can arise when combinations of alleles at more than one locus have low fitness but where possession of one of those alleles has little or no fitness consequence for the carriers. Limited dispersal with small numbers of mate potentials alone can lead to the evolution of clusters of reproductively isolated genotypes despite the absence of any geographical barriers or heterogeneous selection. In this paper, we explore how adding heterogeneous natural selection on the genotypes (e...
2016: Frontiers in Genetics
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