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https://www.readbyqxmd.com/read/28814064/electrical-properties-assessed-by-bioelectrical-impedance-spectroscopy-as-biomarkers-of-age-related-loss-of-skeletal-muscle-quantity-and-quality
#1
Yosuke Yamada, Bjoern Buehring, Diane Krueger, Rozalyn M Anderson, Dale A Schoeller, Neil Binkley
Skeletal muscle, in addition to being comprised of a heterogeneous muscle fiber population, also includes extracellular components that do not contribute to positive tensional force production. Here we test segmental bioelectrical impedance spectroscopy (S-BIS) to assess muscle intracellular mass and composition. S-BIS can evaluate electrical properties that may be related to muscle force production. Muscle fiber membranes separate the intracellular components from the extracellular environment and consist of lipid bilayers which act as an electrical capacitor...
September 1, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28814041/assessing-bradykinesia-in-parkinson-s-disease-using-gyroscope-signals
#2
S Summa, J Tosi, F Taffoni, L Di Biase, M Marano, A Cascio Rizzo, M Tombini, G Di Pino, D Formica
Parkinson's disease (PD) is a neurodegenerative brain disorder that slowly brings on the dopaminergic neurons death. The depletion of the dopaminergic signal causes the onset of motor symptoms such as tremor, bradykinesia and rigidity. Usually, neurologists regularly monitor motor symptoms and motor fluctuations using the MDS-UPDRS part III clinical scale. Nevertheless, to have a more objective and quantitative evaluation, it is possible to assess the cardinal motor symptoms of PD using wearable sensors and portable robotic devices...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28814014/bio-inspired-control-of-joint-torque-and-knee-stiffness-in-a-robotic-lower-limb-exoskeleton-using-a-central-pattern-generator
#3
Stefan O Sobrade, Yannik Nager, Amy R Wu, Roger Gassert, Auke Ijspeert
Robotic lower limb exoskeletons are becoming increasingly popular in therapy and recreational use. However, most exoskeletons are still rather limited in their locomotion speed and the activities of daily live they can perform. Furthermore, they typically do not allow for a dynamic adaptation to the environment, as they are often controlled with predefined reference trajectories. Inspired by human leg stiffness modulation during walking, variable stiffness actuators increase flexibility without the need for more complex controllers...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813997/dynamic-elasticity-measurement-for-prosthetic-socket-design
#4
Yujin Kim, Junghoon Kim, Hyeryon Son, Youngjin Choi
The paper proposes a novel apparatus to measure the dynamic elasticity of human limb in order to help the design and fabrication of the personalized prosthetic socket. To take measurements of the dynamic elasticity, the desired force generated as an exponential chirp signal in which the frequency increases and amplitude is maintained according to time progress is applied to human limb and then the skin deformation is recorded, ultimately, to obtain the frequency response of its elasticity. It is referred to as a Dynamic Elasticity Measurement Apparatus (DEMA) in the paper...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813989/quantification-of-information-transfer-rate-of-the-human-hand-during-a-mouse-clicking-task-with-healthy-adults-and-one-adult-with-duchenne-muscular-dystrophy
#5
Kostas Nizamis, Wouter Schutte, Jasper Goseling, Bart F J M Koopman
Duchenne muscular Dystrophy (DMD) Is a progressive muscle degenerative disease. Active hand assistive devices, can improve the quality of life of people with DMD. Such devices show a rejection rate due to complexity. Our hypothesis is, that a simple orthosis might prove more functional and realistic in assisting people with DMD. To investigate, we developed a portable setup that provides various visual stimuli and records the response of the subjects' fingers through a mouse clicking task. Six LEDs served as visual stimuli...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813902/hybrid-position-and-orientation-tracking-for-a-passive-rehabilitation-table-top-robot
#6
K K Wojewoda, P R Culmer, J F Gallagher, A E Jackson, M C Levesley
This paper presents a real time hybrid 2D position and orientation tracking system developed for an upper limb rehabilitation robot. Designed to work on a table-top, the robot is to enable home-based upper-limb rehabilitative exercise for stroke patients. Estimates of the robot's position are computed by fusing data from two tracking systems, each utilizing a different sensor type: laser optical sensors and a webcam. Two laser optical sensors are mounted on the underside of the robot and track the relative motion of the robot with respect to the surface on which it is placed...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813833/an-integrated-gait-rehabilitation-training-based-on-functional-electrical-stimulation-cycling-and-overground-robotic-exoskeleton-in-complete-spinal-cord-injury-patients-preliminary-results
#7
S Mazzoleni, E Battini, A Rustici, G Stampacchia
The aim of this study is to investigate the effects of an integrated gait rehabilitation training based on Functional Electrical Stimulation (FES)-cycling and overground robotic exoskeleton in a group of seven complete spinal cord injury patients on spasticity and patient-robot interaction. They underwent a robot-assisted rehabilitation training based on two phases: n=20 sessions of FES-cycling followed by n= 20 sessions of robot-assisted gait training based on an overground robotic exoskeleton. The following clinical outcome measures were used: Modified Ashworth Scale (MAS), Numerical Rating Scale (NRS) on spasticity, Penn Spasm Frequency Scale (PSFS), Spinal Cord Independence Measure Scale (SCIM), NRS on pain and International Spinal Cord Injury Pain Data Set (ISCI)...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813804/leap-motion-evaluation-for-assessment-of-upper-limb-motor-skills-in-parkinson-s-disease
#8
A H Butt, E Rovini, C Dolciotti, P Bongioanni, G De Petris, F Cavallo
The main goal of this study is to investigate the potential of the Leap Motion Controller (LMC) for the objective assessment of motor dysfunctioning in patients with Parkinson's disease (PwPD). The most relevant clinical signs in Parkinson's Disease (PD), such as slowness of movements, frequency variation, amplitude variation, and speed, were extracted from the recorded LMC data. Data were clinically quantified using the LMC software development kit (SDK). In this study, 16 PwPD subjects and 12 control healthy subjects were involved...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813798/a-novel-method-for-muscle-fatigue-assessment-during-robot-based-tracking-tasks
#9
Maddalena Mugnosso, Francesca Marini, Matteo Gillardo, Pietro Morasso, Jacopo Zenzeri
In this work we propose a novel method based on sEMG signals, easy and fast to perform, administered with a robotic device to maximize repeatability and objectivity. Muscle fatigue, which is frequently experienced by healthy subjects, can be a highly debilitating symptom in case of neuromuscular disorders. Its assessment provides crucial information on the progression of the disability itself, on patient's muscular function and on the efficacy of the eventual clinical intervention. Hence, a robust and objective protocol for fatigue assessment is fundamental in rehabilitation practice...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813795/electromechanical-delay-in-the-tibialis-anterior-muscle-during-time-varying-ankle-dorsiflexion
#10
A Ubeda, A Del Vecchio, M Sartori, S T Puente, F Torres, J M Azorin, D Farina
We evaluated the electromechanical delay (EMD) for the tibialis anterior (TA) muscle during the performance of time-varying ankle dorsiflexions. Subjects were asked to track a sinusoidal trajectory, for a range of amplitudes and frequencies. Motor unit (MU) action potential trains were identified from surface electromyography (EMG) decomposition and summed to generate the cumulative spike train (CST). CST and the exerted force were cross-correlated to identify the delay between the CST and force, which was considered as an estimate of the EMD...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813716/no-correlation-of-the-disease-severity-of-influenza-a-virus-infection-with-the-rs12252-polymorphism-of-the-interferon-induced-transmembrane-protein-3-gene
#11
Yong-Chan Kim, Byung-Hoon Jeong
The 2009 H1N1 influenza pandemic, which involved a more pathogenic virus than seasonal influenza viruses, rapidly spread around the world and caused many deaths in humans. The members of the interferon-induced transmembrane (IFITM) protein family prevent viral replication and are crucial for defending the host cell against influenza A virus (IAV). Several studies suggest that the CC genotype at the single nucleotide polymorphism (SNP) rs12252 of IFITM3 confers a genetic predisposition to pandemic influenza A in Europeans and Han Chinese, although one study in a British cohort failed to show an association...
August 17, 2017: Intervirology
https://www.readbyqxmd.com/read/28813712/management-of-the-perineum-during-delivery-with-the-kiwi-omnicup-effects-of-mediolateral-episiotomy-on-anal-sphincter-tears-in-nulliparous-women
#12
Barbara Bodner-Adler, Oliver Kimberger, Andreas Käfer, Peter Husslein, Klaus Bodner
AIM: The main objective of this study was to evaluate the association of mediolateral episiotomy with severe perineal trauma during Kiwi omnicup vacuum delivery. METHODS: This retrospective study analyzed all Kiwi omnicup vacuum deliveries between 2010 and 2015 in nulliparous women. Secondary outcomes of interest included frequency of genital tract trauma, outcome of Kiwi extraction and influence on neonatal parameters. RESULTS: A total of 572 nulliparous women who were delivered with the aid of vacuum were analyzed...
August 17, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28813703/efficacy-and-safety-of-adjuvant-treatment-with-entacapone-in-advanced-parkinson-s-disease-with-motor-fluctuation-a-systematic-meta-analysis
#13
Jia Li, Zhiwei Lou, Xiaoyang Liu, Yajuan Sun, Jiajun Chen
AIMS: To assess the efficacy and safety of adjuvant treatment with entacapone in the treatment of later Parkinson's disease (PD) patients with motor fluctuation. METHODS: We conducted a systematic review of relevant studies from 8 databases to June 23, 2016. RESULTS: Fourteen studies were included in this review (n = 2,804). The results showed that compared with placebo, adjuvant therapy with entacapone significantly increased on time (p < 0...
August 16, 2017: European Neurology
https://www.readbyqxmd.com/read/28813627/the-impact-on-resource-utilization-of-supportive-care-consults-on-patients-at-the-university-of-north-carolina-hospital-2010-2012
#14
Kristen Westfall, Dominic Moore, Matthew Meeneghan, Sandra Jarr, John Valgus, Stephen Bernard
BACKGROUND: Cancer patients have a high rate of emergency department (ED) visits and inpatient hospitalizations (IHs) that may be reduced by use of outpatient palliative care services. OBJECTIVE: To determine whether the outpatient adult palliative care service at the University of North Carolina (UNC) Hospital, begun in 2008, reduced the frequency of ED visits and IH during a two-year period. DESIGN: The charts of patients with lung cancer or head and neck cancer seen by the supportive care service from 2010 to 2011, and of a contemporaneous set of potential consults that were not seen, were retrospectively reviewed to determine the impact of this care delivery model...
August 16, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/28813566/a-nonlinear-generalization-of-the-savitzky-golay-filter-and-the-quantitative-analysis-of-saccades
#15
Weiwei Dai, Ivan Selesnick, John-Ross Rizzo, Janet Rucker, Todd Hudson
The Savitzky-Golay (SG) filter is widely used to smooth and differentiate time series, especially biomedical data. However, time series that exhibit abrupt departures from their typical trends, such as sharp waves or steps, which are of physiological interest, tend to be oversmoothed by the SG filter. Hence, the SG filter tends to systematically underestimate physiological parameters in certain situations. This article proposes a generalization of the SG filter to more accurately track abrupt deviations in time series, leading to more accurate parameter estimates (e...
August 1, 2017: Journal of Vision
https://www.readbyqxmd.com/read/28813565/selectivity-hyperselectivity-and-the-tuning-of-v1-neurons
#16
Kedarnath P Vilankar, David J Field
In this article, we explore two forms of selectivity in sensory neurons. The first we call classic selectivity, referring to the stimulus that optimally stimulates a neuron. If a neuron is linear, then this stimulus can be determined by measuring the response to an orthonormal basis set (the receptive field). The second type of selectivity we call hyperselectivity; it is either implicitly or explicitly a component of several models including sparse coding, gain control, and some linear-nonlinear models. Hyperselectivity is unrelated to the stimulus that maximizes the response...
August 1, 2017: Journal of Vision
https://www.readbyqxmd.com/read/28813560/prevalence-of-pubic-hair-grooming-related-injuries-and-identification-of-high-risk-individuals-in-the-united-states
#17
Matthew D Truesdale, E Charles Osterberg, Thomas W Gaither, Mohannad A Awad, Molly A Elmer-DeWitt, Siobhan Sutcliffe, Isabel Allen, Benjamin N Breyer
Importance: Pubic hair grooming is a common practice that can lead to injury and morbidity. Objective: To identify demographic and behavioral risk factors associated with pubic hair grooming-related injuries to characterize individuals with high risk of injury and develop recommendations for safe grooming practices. Design, Setting, and Participants: This cross-sectional study conducted a national survey of noninstitutionalized US adults (aged 18-65 years)...
August 16, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28813528/maternal-and-fetal-risk-factors-for-stillbirth-in-northern-tanzania-a-registry-based-retrospective-cohort-study
#18
Francisca S Chuwa, Amasha H Mwanamsangu, Benjamin G Brown, Sia E Msuya, Elizabeth E Senkoro, Oresta P Mnali, Festo Mazuguni, Michael J Mahande
BACKGROUND: Stillbirth is a major cause of perinatal mortality and occurs disproportionately in developing countries including Tanzania. However, there is scant information regarding the predictors of this condition in Tanzania. This study aimed to determine maternal and fetal risk factors for stilbirth in northen Tanzania. METHODOLOGY: A retrospective cohort study was performed using maternally-linked data from the Kilimanjaro Christian Medical Centre birth registry...
2017: PloS One
https://www.readbyqxmd.com/read/28813520/the-frequency-of-class1-and-2-integrons-in-pseudomonas-aeruginosa-strains-isolated-from-burn-patients-in-a-burn-center-of-ahvaz-iran
#19
Azar Dokht Khosravi, Moloudsadat Motahar, Effat Abbasi Montazeri
BACKGROUND: Pseudomonas aeruginosa is an opportunistic pathogen with the ability to cause severe nosocomial infections and remains a major problem in burn patients. This organism shows a remarkable antimicrobial resistance and is often resistant to multiple antibiotics. Integron genes as mobile genetic elements are playing an important role in the spread of P. aeruginosa antibiotic resistance. This study was aimed to investigate the occurrence of class 1, and 2 integron genes (int1, int2), among P...
2017: PloS One
https://www.readbyqxmd.com/read/28813500/telomere-biology-and-telomerase-mutations-in-cirrhotic-patients-with-hepatocellular-carcinoma
#20
Flávia S Donaires, Natália F Scatena, Raquel M Alves-Paiva, Joshua D Podlevsky, Dhenugen Logeswaran, Barbara A Santana, Andreza C Teixeira, Julian J-L Chen, Rodrigo T Calado, Ana L C Martinelli
Telomeres are repetitive DNA sequences at linear chromosome termini, protecting chromosomes against end-to-end fusion and damage, providing chromosomal stability. Telomeres shorten with mitotic cellular division, but are maintained in cells with high proliferative capacity by telomerase. Loss-of-function mutations in telomere-maintenance genes are genetic risk factors for cirrhosis development in humans and murine models. Telomerase deficiency provokes accelerated telomere shortening and dysfunction, facilitating genomic instability and oncogenesis...
2017: PloS One
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